locus-tag	class	description
AV939_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AV939_00020	COG0187	DNA topoisomerase II activity
AV939_00045	COG2818	Glycosylase
AV939_00055	COG3078	GTPase activator activity
AV939_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AV939_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AV939_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AV939_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AV939_00085	COG0569	domain protein
AV939_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AV939_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AV939_00110	COG0758	DNA mediated transformation
AV939_00125	COG0009	L-threonylcarbamoyladenylate synthase
AV939_00130	COG0408	coproporphyrinogen oxidase activity
AV939_00135	COG3047	cAMP biosynthetic process
AV939_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AV939_00205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AV939_00225	COG2234	aminopeptidase activity
AV939_00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AV939_00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AV939_00305	COG3642	lipopolysaccharide core region biosynthetic process
AV939_00310	COG0859	PFAM glycosyl transferase family 9
AV939_00330	COG0156	8-amino-7-oxononanoate synthase activity
AV939_00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AV939_00345	COG0705	Rhomboid family
AV939_00355	COG3161	chorismate lyase activity
AV939_00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AV939_00365	COG2960	long-chain fatty acid transporting porin activity
AV939_00370	COG0210	DNA helicase
AV939_00465	COG1620	l-lactate permease
AV939_00485	COG1902	pentaerythritol trinitrate reductase activity
AV939_00485	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV939_00505	COG4638	Rieske (2fe-2S)
AV939_00515	COG1017	nitric oxide dioxygenase activity
AV939_00515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AV939_00520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AV939_00560	COG1760	l-serine dehydratase
AV939_00565	COG0583	DNA-binding transcription factor activity
AV939_00580	COG1012	belongs to the aldehyde dehydrogenase family
AV939_00585	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_00595	COG1012	belongs to the aldehyde dehydrogenase family
AV939_00600	COG4771	TonB-dependent receptor
AV939_00605	COG0457	Tetratricopeptide repeat
AV939_00610	COG3850	Histidine kinase
AV939_00610	COG2205	protein histidine kinase activity
AV939_00610	COG3437	response regulator, receiver
AV939_00610	COG4999	Histidine kinase
AV939_00615	COG4773	Receptor
AV939_00620	COG0583	DNA-binding transcription factor activity
AV939_00635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_00640	COG1129	ABC transporter
AV939_00640	COG0842	Transport permease protein
AV939_00645	COG0842	Transport permease protein
AV939_00655	COG1960	acyl-CoA dehydrogenase activity
AV939_00660	COG0583	DNA-binding transcription factor activity
AV939_00675	COG3106	COG3106 Predicted ATPase
AV939_00695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AV939_00710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AV939_00725	COG4771	TonB-dependent receptor
AV939_00730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV939_00740	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AV939_00740	COG0778	Nitroreductase
AV939_00755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AV939_00760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AV939_00765	COG1309	transcriptional regulator
AV939_00790	COG1953	Uracil, thiamine, allantoin
AV939_00800	COG3071	HemY protein
AV939_00805	COG2959	enzyme of heme biosynthesis
AV939_00815	COG0181	hydroxymethylbilane synthase activity
AV939_00820	COG3706	GGDEF domain
AV939_00820	COG0745	RESPONSE REGULATOR receiver
AV939_00830	COG0194	GDP metabolic process
AV939_00840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AV939_00850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV939_00855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AV939_00865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AV939_00865	COG0678	peroxiredoxin activity
AV939_00885	COG1178	ABC-type Fe3 transport system permease component
AV939_00890	COG3842	ATPase activity
AV939_00895	COG2081	HI0933 family
AV939_00900	COG0668	transmembrane transport
AV939_00925	COG5002	protein histidine kinase activity
AV939_00925	COG3447	MASE1 domain protein
AV939_00925	COG5001	Diguanylate cyclase
AV939_00935	COG0583	DNA-binding transcription factor activity
AV939_00945	COG2076	Multidrug Resistance protein
AV939_00960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_00965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_00975	COG0427	acetyl-CoA hydrolase
AV939_00980	COG0123	including yeast histone deacetylase and acetoin utilization protein
AV939_00990	COG0840	transmembrane signaling receptor activity
AV939_01000	COG3064	Membrane
AV939_01005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AV939_01010	COG5001	Diguanylate cyclase
AV939_01010	COG5002	protein histidine kinase activity
AV939_01020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AV939_01030	COG0514	ATP-dependent DNA helicase (RecQ)
AV939_01035	COG2050	protein possibly involved in aromatic compounds catabolism
AV939_01040	COG2239	Acts as a magnesium transporter
AV939_01050	COG3706	GGDEF domain
AV939_01050	COG0745	RESPONSE REGULATOR receiver
AV939_01065	COG1011	Hydrolase
AV939_01080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AV939_01085	COG0019	diaminopimelate decarboxylase activity
AV939_01115	COG0163	prenyltransferase activity
AV939_01120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AV939_01130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AV939_01155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AV939_01160	COG2814	Major facilitator Superfamily
AV939_01165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_01185	COG1085	galactose-1-phosphate uridylyltransferase
AV939_01190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AV939_01200	COG0629	single-stranded DNA binding
AV939_01240	COG3710	Transcriptional regulator
AV939_01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AV939_01270	COG4615	Cyclic peptide transporter
AV939_01285	COG0745	RESPONSE REGULATOR receiver
AV939_01295	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AV939_01325	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_01350	COG1349	DNA-binding transcription factor activity
AV939_01390	COG3267	Type II secretory pathway component ExeA
AV939_01390	COG3409	Peptidoglycan-binding domain 1 protein
AV939_01400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AV939_01405	COG1459	type II secretion system
AV939_01445	COG1077	Cell shape determining protein MreB Mrl
AV939_01450	COG1792	Involved in formation and maintenance of cell shape
AV939_01455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AV939_01465	COG1530	ribonuclease E activity
AV939_01475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV939_01480	COG0312	modulator of DNA gyrase
AV939_01490	COG3028	Belongs to the UPF0307 family
AV939_01495	COG0312	modulator of DNA gyrase
AV939_01510	COG0745	RESPONSE REGULATOR receiver
AV939_01515	COG4191	Histidine kinase
AV939_01515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_01520	COG0297	glycogen (starch) synthase activity
AV939_01530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AV939_01540	COG1194	a g-specific adenine glycosylase
AV939_01595	COG0745	RESPONSE REGULATOR receiver
AV939_01600	COG2198	Histidine kinase
AV939_01600	COG0643	Histidine kinase
AV939_01605	COG0835	chemotaxis
AV939_01620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AV939_01625	COG2201	protein-glutamate methylesterase activity
AV939_01640	COG0501	Belongs to the peptidase M48B family
AV939_01705	COG1609	Transcriptional regulator
AV939_01710	COG0673	inositol 2-dehydrogenase activity
AV939_01720	COG2211	Major facilitator Superfamily
AV939_01770	COG1454	alcohol dehydrogenase
AV939_01795	COG0051	transcription antitermination factor activity, RNA binding
AV939_01810	COG0089	rRNA binding
AV939_01820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AV939_01830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AV939_01845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AV939_01850	COG0438	transferase activity, transferring glycosyl groups
AV939_01855	COG0859	PFAM glycosyl transferase family 9
AV939_01860	COG1519	Transferase
AV939_01885	COG0339	signal peptide processing
AV939_01895	COG0788	formyltetrahydrofolate deformylase activity
AV939_01905	COG1643	Atp-dependent helicase
AV939_01910	COG2951	lytic endotransglycosylase activity
AV939_01920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AV939_01930	COG2354	Protein conserved in bacteria
AV939_01955	COG0004	ammonium transporteR
AV939_01960	COG0405	Gamma-glutamyltransferase
AV939_01965	COG2837	iron assimilation
AV939_01980	COG0540	Belongs to the ATCase OTCase family
AV939_02005	COG0784	Response regulator, receiver
AV939_02005	COG2205	protein histidine kinase activity
AV939_02005	COG5002	protein histidine kinase activity
AV939_02030	COG1012	belongs to the aldehyde dehydrogenase family
AV939_02040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AV939_02050	COG0512	Glutamine amidotransferase of anthranilate synthase
AV939_02055	COG0180	Tryptophanyl-tRNA synthetase
AV939_02060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AV939_02080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AV939_02090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AV939_02125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AV939_02130	COG0281	malic enzyme
AV939_02135	COG0625	glutathione transferase activity
AV939_02170	COG5001	Diguanylate cyclase
AV939_02170	COG3300	MHYT domain
AV939_02175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AV939_02175	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AV939_02185	COG0137	argininosuccinate synthase activity
AV939_02190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AV939_02205	COG1803	Methylglyoxal synthase
AV939_02215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AV939_02230	COG0745	RESPONSE REGULATOR receiver
AV939_02235	COG2205	protein histidine kinase activity
AV939_02240	COG2267	carboxylic ester hydrolase activity
AV939_02245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AV939_02260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AV939_02270	COG4942	peptidase
AV939_02280	COG2861	carbohydrate metabolic process
AV939_02290	COG0584	glycerophosphoryl diester phosphodiesterase
AV939_02305	COG1162	GTPase activity
AV939_02310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AV939_02330	COG0457	Tetratricopeptide repeat
AV939_02345	COG0028	Belongs to the TPP enzyme family
AV939_02365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AV939_02370	COG0805	protein transport
AV939_02385	COG3706	GGDEF domain
AV939_02395	COG0248	Ppx GppA phosphatase
AV939_02400	COG0513	Belongs to the DEAD box helicase family
AV939_02405	COG3118	belongs to the thioredoxin family
AV939_02410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AV939_02420	COG2205	protein histidine kinase activity
AV939_02420	COG0784	Response regulator, receiver
AV939_02425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AV939_02435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AV939_02450	COG0783	Belongs to the Dps family
AV939_02455	COG2133	pyrroloquinoline quinone binding
AV939_02465	COG3118	belongs to the thioredoxin family
AV939_02475	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AV939_02485	COG1012	belongs to the aldehyde dehydrogenase family
AV939_02505	COG1757	Na H antiporter
AV939_02525	COG3876	Protein conserved in bacteria
AV939_02530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AV939_02550	COG0346	lactoylglutathione lyase activity
AV939_02565	COG0840	transmembrane signaling receptor activity
AV939_02625	COG4115	mRNA cleavage
AV939_02630	COG2161	toxin-antitoxin pair type II binding
AV939_02730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AV939_02735	COG0666	response to abiotic stimulus
AV939_02805	COG0596	Alpha beta hydrolase
AV939_02810	COG1960	acyl-CoA dehydrogenase activity
AV939_02815	COG0183	Belongs to the thiolase family
AV939_02820	COG1024	Enoyl-CoA hydratase
AV939_02820	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV939_02825	COG0596	Alpha beta hydrolase
AV939_02855	COG1960	acyl-CoA dehydrogenase activity
AV939_02865	COG4771	TonB-dependent receptor
AV939_02885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AV939_02890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AV939_02905	COG0314	molybdopterin synthase activity
AV939_02910	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AV939_02915	COG0315	cyclic pyranopterin monophosphate synthase activity
AV939_02920	COG0521	Mo-molybdopterin cofactor biosynthetic process
AV939_02925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AV939_02990	COG0183	Belongs to the thiolase family
AV939_02995	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV939_02995	COG1024	Enoyl-CoA hydratase
AV939_03005	COG0006	proline dipeptidase activity
AV939_03015	COG0142	geranyltranstransferase activity
AV939_03075	COG1238	metal cluster binding
AV939_03085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AV939_03090	COG0585	pseudouridine synthase activity
AV939_03105	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AV939_03115	COG0840	transmembrane signaling receptor activity
AV939_03120	COG0506	proline dehydrogenase activity
AV939_03120	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AV939_03120	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AV939_03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_03145	COG2770	Histidine kinase
AV939_03145	COG2205	protein histidine kinase activity
AV939_03150	COG4991	sh3 domain protein
AV939_03155	COG3025	triphosphatase activity
AV939_03170	COG0494	nUDIX hydrolase
AV939_03175	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AV939_03180	COG0730	response to heat
AV939_03185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AV939_03190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AV939_03195	COG2201	protein-glutamate methylesterase activity
AV939_03200	COG3706	GGDEF domain
AV939_03205	COG0784	Response regulator, receiver
AV939_03205	COG5002	protein histidine kinase activity
AV939_03225	COG0564	pseudouridine synthase activity
AV939_03235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AV939_03245	COG1802	Transcriptional regulator
AV939_03250	COG3119	arylsulfatase activity
AV939_03255	COG1012	belongs to the aldehyde dehydrogenase family
AV939_03260	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_03265	COG1063	alcohol dehydrogenase
AV939_03270	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_03275	COG2814	Major facilitator Superfamily
AV939_03295	COG2124	cytochrome p450
AV939_03395	COG3119	arylsulfatase activity
AV939_03430	COG3119	arylsulfatase activity
AV939_03445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AV939_03445	COG1648	precorrin-2 dehydrogenase activity
AV939_03465	COG1538	Outer membrane efflux protein
AV939_03470	COG0494	nUDIX hydrolase
AV939_03485	COG3150	esterase
AV939_03500	COG4251	negative regulation of phosphorylation
AV939_03505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_03525	COG1509	lysine 2,3-aminomutase activity
AV939_03555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AV939_03570	COG0271	Belongs to the BolA IbaG family
AV939_03575	COG0671	phosphoesterase, PA-phosphatase related
AV939_03585	COG3707	response regulator
AV939_03595	COG0659	secondary active sulfate transmembrane transporter activity
AV939_03600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AV939_03605	COG2146	nitrite reductase [NAD(P)H] activity
AV939_03610	COG0243	molybdopterin cofactor binding
AV939_03615	COG1648	precorrin-2 dehydrogenase activity
AV939_03615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AV939_03630	COG1116	anion transmembrane transporter activity
AV939_03630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AV939_03635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AV939_03640	COG1116	anion transmembrane transporter activity
AV939_03655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AV939_03660	COG4206	TonB-dependent receptor
AV939_03665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AV939_03670	COG0348	domain, Protein
AV939_03685	COG1960	acyl-CoA dehydrogenase activity
AV939_03690	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_03710	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_03730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_03750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AV939_03755	COG0358	DNA primase activity
AV939_03760	COG1610	YqeY-like protein
AV939_03780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AV939_03785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AV939_03800	COG0537	adenosine 5'-monophosphoramidase activity
AV939_03815	COG3135	benzoate transporter
AV939_03820	COG1396	sequence-specific DNA binding
AV939_03825	COG2974	May be involved in recombination
AV939_03830	COG4191	Histidine kinase
AV939_03830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_03835	COG0745	RESPONSE REGULATOR receiver
AV939_03840	COG5002	protein histidine kinase activity
AV939_03870	COG0811	peptide transport
AV939_03875	COG0811	peptide transport
AV939_03880	COG0848	biopolymer transport protein
AV939_03885	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AV939_03895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AV939_03900	COG3437	response regulator, receiver
AV939_03910	COG0318	PFAM AMP-dependent synthetase and ligase
AV939_03920	COG2133	pyrroloquinoline quinone binding
AV939_03925	COG1049	propionate catabolic process, 2-methylcitrate cycle
AV939_03945	COG0527	aspartate kinase activity
AV939_03950	COG0840	transmembrane signaling receptor activity
AV939_03955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AV939_03965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AV939_03970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AV939_03975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AV939_03980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AV939_03985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AV939_03995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AV939_04015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AV939_04025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AV939_04030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AV939_04035	COG3956	TIGRFAM MazG family protein
AV939_04055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AV939_04060	COG1595	DNA-templated transcription, initiation
AV939_04070	COG4206	TonB-dependent receptor
AV939_04080	COG1473	amidohydrolase
AV939_04085	COG0723	plastoquinol--plastocyanin reductase activity
AV939_04090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AV939_04095	COG2857	Cytochrome c1
AV939_04100	COG0625	glutathione transferase activity
AV939_04105	COG2969	positive regulation of protein catabolic process
AV939_04110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_04110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_04115	COG3708	Transcriptional regulator
AV939_04115	COG2207	Transcriptional regulator
AV939_04125	COG2239	Acts as a magnesium transporter
AV939_04130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AV939_04140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AV939_04150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AV939_04155	COG1137	ATPase activity
AV939_04170	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AV939_04185	COG1127	ABC transporter
AV939_04190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AV939_04195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AV939_04200	COG2854	intermembrane phospholipid transfer
AV939_04210	COG5007	Belongs to the BolA IbaG family
AV939_04220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AV939_04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AV939_04235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AV939_04250	COG2207	Transcriptional regulator
AV939_04265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV939_04280	COG3300	MHYT domain
AV939_04280	COG5001	Diguanylate cyclase
AV939_04285	COG0784	Response regulator, receiver
AV939_04285	COG2205	protein histidine kinase activity
AV939_04290	COG0683	leucine binding
AV939_04295	COG2207	Transcriptional regulator
AV939_04300	COG1979	alcohol dehydrogenase
AV939_04325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AV939_04335	COG0126	phosphoglycerate kinase activity
AV939_04340	COG3588	fructose-bisphosphate aldolase
AV939_04345	COG0823	Involved in the tonB-independent uptake of proteins
AV939_04345	COG1506	peptidase
AV939_04345	COG4946	Tricorn protease homolog
AV939_04350	COG0248	Ppx GppA phosphatase
AV939_04355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AV939_04365	COG0573	inorganic phosphate transmembrane transporter activity
AV939_04370	COG0581	inorganic phosphate transmembrane transporter activity
AV939_04375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AV939_04385	COG0306	phosphate transporter
AV939_04395	COG0583	DNA-binding transcription factor activity
AV939_04420	COG1272	protein, Hemolysin III
AV939_04440	COG0477	Major facilitator Superfamily
AV939_04445	COG2207	Transcriptional regulator
AV939_04445	COG1609	Transcriptional regulator
AV939_04450	COG1070	Carbohydrate kinase
AV939_04455	COG2115	Belongs to the xylose isomerase family
AV939_04460	COG5520	Belongs to the glycosyl hydrolase 30 family
AV939_04460	COG4447	cellulose binding
AV939_04460	COG3291	Pkd domain containing protein
AV939_04465	COG2207	Transcriptional regulator
AV939_04480	COG1472	Belongs to the glycosyl hydrolase 3 family
AV939_04485	COG1846	Transcriptional regulator
AV939_04490	COG1764	response to oxidative stress
AV939_04505	COG1739	Uncharacterized protein family UPF0029
AV939_04515	COG0420	3'-5' exonuclease activity
AV939_04520	COG0419	ATPase involved in DNA repair
AV939_04525	COG3706	GGDEF domain
AV939_04535	COG2971	BadF BadG BcrA BcrD
AV939_04540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AV939_04545	COG1752	Esterase of the alpha-beta hydrolase superfamily
AV939_04550	COG0488	(ABC) transporter
AV939_04585	COG4667	esterase of the alpha-beta hydrolase superfamily
AV939_04655	COG1346	cytolysis
AV939_04685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AV939_04695	COG0513	Belongs to the DEAD box helicase family
AV939_04705	COG3267	Type II secretory pathway component ExeA
AV939_04705	COG3409	Peptidoglycan-binding domain 1 protein
AV939_04715	COG3437	response regulator, receiver
AV939_04715	COG0784	Response regulator, receiver
AV939_04720	COG0066	3-isopropylmalate dehydratase activity
AV939_04730	COG0473	3-isopropylmalate dehydrogenase activity
AV939_04735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AV939_04765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AV939_04780	COG4555	ABC transporter
AV939_04785	COG1668	transmembrane transport
AV939_04805	COG4133	protoheme IX ABC transporter activity
AV939_04810	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV939_04815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV939_04820	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV939_04830	COG1138	Cytochrome C-type biogenesis protein
AV939_04835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AV939_04850	COG2853	Lipoprotein
AV939_04855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AV939_04865	COG3104	oligopeptide transport
AV939_04880	COG1682	transport, permease protein
AV939_04910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AV939_04915	COG1555	photosystem II stabilization
AV939_04915	COG1596	polysaccharide export
AV939_04920	COG0473	3-isopropylmalate dehydrogenase activity
AV939_04935	COG1611	Belongs to the LOG family
AV939_04940	COG0745	RESPONSE REGULATOR receiver
AV939_04940	COG3706	GGDEF domain
AV939_04945	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AV939_04945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AV939_05015	COG0564	pseudouridine synthase activity
AV939_05035	COG0024	Methionine aminopeptidase
AV939_05040	COG0052	Belongs to the universal ribosomal protein uS2 family
AV939_05050	COG0528	UMP kinase activity
AV939_05060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AV939_05065	COG0575	Belongs to the CDS family
AV939_05070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AV939_05075	COG0750	zinc metalloprotease
AV939_05090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AV939_05095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AV939_05110	COG0587	DNA-directed DNA polymerase activity
AV939_05115	COG0825	malonyl-CoA metabolic process
AV939_05120	COG0037	tRNA processing
AV939_05140	COG0590	tRNA wobble adenosine to inosine editing
AV939_05150	COG0047	phosphoribosylformylglycinamidine synthase activity
AV939_05150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AV939_05155	COG2840	Smr protein MutS2
AV939_05180	COG3547	Transposase (IS116 IS110 IS902 family)
AV939_05185	COG0513	Belongs to the DEAD box helicase family
AV939_05190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AV939_05195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AV939_05200	COG0583	DNA-binding transcription factor activity
AV939_05220	COG1760	l-serine dehydratase
AV939_05225	COG0494	nUDIX hydrolase
AV939_05230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AV939_05240	COG1322	Protein conserved in bacteria
AV939_05245	COG1404	Belongs to the peptidase S8 family
AV939_05250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AV939_05255	COG0022	dehydrogenase e1 component
AV939_05260	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV939_05265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AV939_05270	COG0515	serine threonine protein kinase
AV939_05275	COG1946	Acyl-CoA thioesterase
AV939_05285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AV939_05295	COG1956	GAF domain-containing protein
AV939_05310	COG0793	Belongs to the peptidase S41A family
AV939_05315	COG0733	neurotransmitter:sodium symporter activity
AV939_05325	COG0308	aminopeptidase N
AV939_05355	COG2902	Dehydrogenase
AV939_05360	COG0167	dihydroorotate dehydrogenase activity
AV939_05385	COG3130	regulation of translation
AV939_05390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AV939_05400	COG0415	Belongs to the DNA photolyase family
AV939_05405	COG0415	Belongs to the DNA photolyase family
AV939_05410	COG3046	protein related to deoxyribodipyrimidine photolyase
AV939_05435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AV939_05440	COG0589	response to stress
AV939_05450	COG0069	glutamate synthase activity
AV939_05465	COG2193	ferroxidase activity
AV939_05475	COG3278	Belongs to the heme-copper respiratory oxidase family
AV939_05490	COG2010	Cytochrome c
AV939_05500	COG2217	Heavy metal translocating P-type atpase
AV939_05515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AV939_05525	COG0037	tRNA processing
AV939_05530	COG1752	Esterase of the alpha-beta hydrolase superfamily
AV939_05550	COG1280	lysine exporter protein (LysE YggA)
AV939_05555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AV939_05560	COG2897	thiosulfate sulfurtransferase activity
AV939_05565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AV939_05615	COG0322	excinuclease ABC activity
AV939_05620	COG2197	response regulator
AV939_05625	COG1741	Belongs to the pirin family
AV939_05635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AV939_05655	COG0642	Histidine kinase
AV939_05660	COG0745	RESPONSE REGULATOR receiver
AV939_05685	COG0670	Belongs to the BI1 family
AV939_05695	COG2923	Belongs to the DsrF TusC family
AV939_05705	COG2920	part of a sulfur-relay system
AV939_05710	COG0561	phosphatase activity
AV939_05725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AV939_05730	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AV939_05735	COG0531	amino acid
AV939_05735	COG1674	ftsk spoiiie
AV939_05745	COG0686	Belongs to the AlaDH PNT family
AV939_05750	COG0284	orotidine-5'-phosphate decarboxylase activity
AV939_05755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AV939_05760	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AV939_05770	COG0776	regulation of translation
AV939_05775	COG0539	negative regulation of cytoplasmic translation
AV939_05780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AV939_05785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AV939_05790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AV939_05805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AV939_05810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AV939_05815	COG0633	Ferredoxin
AV939_05820	COG5002	protein histidine kinase activity
AV939_05850	COG0789	Transcriptional regulator
AV939_05945	COG1131	(ABC) transporter
AV939_05980	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AV939_05985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AV939_05995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AV939_06005	COG4783	chaperone-mediated protein folding
AV939_06015	COG1393	Belongs to the ArsC family
AV939_06050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AV939_06085	COG0572	uridine kinase
AV939_06090	COG3769	mannosylglycerate metabolic process
AV939_06095	COG1215	transferase activity, transferring glycosyl groups
AV939_06105	COG0303	'Molybdopterin
AV939_06110	COG0534	Mate efflux family protein
AV939_06130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AV939_06140	COG0405	Gamma-glutamyltransferase
AV939_06145	COG1024	Enoyl-CoA hydratase
AV939_06180	COG1448	Aminotransferase
AV939_06185	COG1671	Belongs to the UPF0178 family
AV939_06190	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_06200	COG1960	acyl-CoA dehydrogenase activity
AV939_06205	COG1917	Cupin 2, conserved barrel domain protein
AV939_06205	COG2207	Transcriptional regulator
AV939_06255	COG0596	Alpha beta hydrolase
AV939_06265	COG0716	FMN binding
AV939_06285	COG3265	gluconokinase activity
AV939_06290	COG1609	Transcriptional regulator
AV939_06300	COG1984	allophanate hydrolase subunit 2
AV939_06310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AV939_06315	COG2996	Protein conserved in bacteria
AV939_06320	COG1765	OsmC-like protein
AV939_06325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_06350	COG0436	Aminotransferase
AV939_06355	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AV939_06360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AV939_06370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AV939_06380	COG1238	metal cluster binding
AV939_06425	COG4628	conserved protein (DUF2132)
AV939_06435	COG0454	-acetyltransferase
AV939_06440	COG1119	ATPase activity
AV939_06450	COG1185	polyribonucleotide nucleotidyltransferase activity
AV939_06475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_06515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AV939_06520	COG0149	triose-phosphate isomerase activity
AV939_06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AV939_06530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AV939_06535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AV939_06540	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AV939_06545	COG1534	Rna-binding protein
AV939_06555	COG1067	ATP-dependent peptidase activity
AV939_06560	COG0495	leucyl-tRNA aminoacylation
AV939_06570	COG1466	dna polymerase III delta subunit
AV939_06575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AV939_06580	COG0799	negative regulation of ribosome biogenesis
AV939_06585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AV939_06590	COG0768	penicillin binding
AV939_06595	COG0772	Belongs to the SEDS family
AV939_06600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AV939_06605	COG1686	Belongs to the peptidase S11 family
AV939_06610	COG2921	Belongs to the UPF0250 family
AV939_06615	COG0321	lipoyl(octanoyl) transferase activity
AV939_06620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AV939_06630	COG0252	asparaginase activity
AV939_06640	COG0778	Nitroreductase
AV939_06655	COG0616	signal peptide processing
AV939_06675	COG0492	ferredoxin-NADP+ reductase activity
AV939_06680	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AV939_06685	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AV939_06690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AV939_06695	COG0542	response to heat
AV939_06700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AV939_06705	COG1278	Cold shock
AV939_06715	COG1187	pseudouridine synthase activity
AV939_06720	COG0482	sulfurtransferase activity
AV939_06725	COG2915	High frequency lysogenization protein hflD homolog
AV939_06730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AV939_06740	COG2850	peptidyl-arginine hydroxylation
AV939_06755	COG0247	lactate metabolic process
AV939_06755	COG0277	FAD linked oxidase domain protein
AV939_06760	COG3123	guanosine phosphorylase activity
AV939_06765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AV939_06810	COG1695	Transcriptional regulator
AV939_06825	COG1077	Cell shape determining protein MreB Mrl
AV939_06850	COG3265	gluconokinase activity
AV939_06860	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_06875	COG1609	Transcriptional regulator
AV939_06880	COG0679	Auxin Efflux Carrier
AV939_06900	COG0574	Belongs to the PEP-utilizing enzyme family
AV939_06900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AV939_06920	COG1942	4-Oxalocrotonate Tautomerase
AV939_06940	COG1714	RDD family
AV939_06960	COG0745	RESPONSE REGULATOR receiver
AV939_06960	COG3706	GGDEF domain
AV939_06965	COG0702	epimerase
AV939_06975	COG0084	hydrolase, TatD family'
AV939_06980	COG0470	DNA polymerase III
AV939_06990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AV939_06995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AV939_07000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AV939_07005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AV939_07020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AV939_07025	COG0416	fatty acid biosynthetic process
AV939_07035	COG1399	metal-binding, possibly nucleic acid-binding protein
AV939_07040	COG0424	maF-like protein
AV939_07045	COG0546	phosphoglycolate phosphatase activity
AV939_07055	COG1530	ribonuclease E activity
AV939_07075	COG2153	protein acetylation
AV939_07095	COG0625	glutathione transferase activity
AV939_07110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AV939_07120	COG0583	DNA-binding transcription factor activity
AV939_07130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AV939_07135	COG3724	N-succinylarginine dihydrolase activity
AV939_07145	COG1301	dicarboxylic acid transport
AV939_07150	COG4591	ABC-type transport system involved in lipoprotein release permease component
AV939_07155	COG1136	(ABC) transporter
AV939_07160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AV939_07190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AV939_07195	COG0328	RNA-DNA hybrid ribonuclease activity
AV939_07220	COG1643	Atp-dependent helicase
AV939_07260	COG3850	Histidine kinase
AV939_07260	COG4999	Histidine kinase
AV939_07260	COG3437	response regulator, receiver
AV939_07260	COG2205	protein histidine kinase activity
AV939_07265	COG2925	Exonuclease
AV939_07280	COG0183	Belongs to the thiolase family
AV939_07285	COG0789	Transcriptional regulator
AV939_07290	COG1960	acyl-CoA dehydrogenase activity
AV939_07295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AV939_07300	COG1024	Enoyl-CoA hydratase
AV939_07335	COG1957	nucleoside hydrolase
AV939_07350	COG2814	Major facilitator Superfamily
AV939_07385	COG0708	Exodeoxyribonuclease III
AV939_07400	COG4591	ABC-type transport system involved in lipoprotein release permease component
AV939_07410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AV939_07420	COG2096	Adenosyltransferase
AV939_07430	COG1472	Belongs to the glycosyl hydrolase 3 family
AV939_07440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AV939_07455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_07455	COG0072	phenylalanine-tRNA ligase activity
AV939_07485	COG2244	polysaccharide biosynthetic process
AV939_07495	COG0463	Glycosyl transferase, family 2
AV939_07500	COG0463	Glycosyl transferase, family 2
AV939_07500	COG1216	Glycosyl transferase, family 2
AV939_07515	COG1045	serine acetyltransferase
AV939_07525	COG0438	transferase activity, transferring glycosyl groups
AV939_07560	COG4464	protein tyrosine phosphatase activity
AV939_07565	COG0489	protein tyrosine kinase activity
AV939_07570	COG1596	polysaccharide export
AV939_07580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AV939_07600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AV939_07615	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_07645	COG0154	amidase activity
AV939_07655	COG0730	response to heat
AV939_07660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AV939_07675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AV939_07680	COG2233	PERMEase
AV939_07695	COG5002	protein histidine kinase activity
AV939_07695	COG0784	Response regulator, receiver
AV939_07700	COG0745	RESPONSE REGULATOR receiver
AV939_07700	COG3706	GGDEF domain
AV939_07705	COG5001	Diguanylate cyclase
AV939_07705	COG3300	MHYT domain
AV939_07715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AV939_07720	COG2252	PERMEase
AV939_07735	COG1309	transcriptional regulator
AV939_07745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AV939_07760	COG2351	hydroxyisourate hydrolase activity
AV939_07765	COG0402	S-adenosylhomocysteine deaminase activity
AV939_07775	COG5002	protein histidine kinase activity
AV939_07775	COG5001	Diguanylate cyclase
AV939_07775	COG3447	MASE1 domain protein
AV939_07795	COG3706	GGDEF domain
AV939_07810	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AV939_07835	COG2211	Major facilitator Superfamily
AV939_07835	COG2190	(PTS) system
AV939_07840	COG1393	Belongs to the ArsC family
AV939_07870	COG2988	succinylglutamate desuccinylase activity
AV939_07880	COG0058	SHG alpha-glucan phosphorylase activity
AV939_07885	COG0033	Phosphoglucomutase
AV939_07890	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AV939_07895	COG0714	Associated with various cellular activities
AV939_07910	COG2116	formate transmembrane transporter activity
AV939_07915	COG0515	serine threonine protein kinase
AV939_07915	COG2815	serine threonine protein kinase
AV939_07920	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AV939_07945	COG0583	DNA-binding transcription factor activity
AV939_07960	COG3094	Invasion gene expression up-regulator, SirB
AV939_07965	COG0784	Response regulator, receiver
AV939_07965	COG3437	response regulator, receiver
AV939_07970	COG2890	protein-(glutamine-N5) methyltransferase activity
AV939_07980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AV939_07985	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AV939_07990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AV939_08000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AV939_08005	COG3300	MHYT domain
AV939_08005	COG5001	Diguanylate cyclase
AV939_08015	COG1064	alcohol dehydrogenase
AV939_08030	COG0012	GTP binding
AV939_08035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AV939_08060	COG1115	amino acid carrier protein
AV939_08065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AV939_08080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AV939_08090	COG1702	phosphate starvation-inducible protein PhoH
AV939_08100	COG4535	Mg2 and Co2 transporter CorC
AV939_08105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AV939_08110	COG0280	phosphate acetyltransferase
AV939_08110	COG0857	belongs to the CobB CobQ family
AV939_08115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AV939_08120	COG0071	Belongs to the small heat shock protein (HSP20) family
AV939_08145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AV939_08150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AV939_08155	COG0505	Belongs to the CarA family
AV939_08160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AV939_08175	COG4251	negative regulation of phosphorylation
AV939_08175	COG2203	Gaf domain
AV939_08175	COG3706	GGDEF domain
AV939_08175	COG5001	Diguanylate cyclase
AV939_08180	COG3909	cytochrome
AV939_08185	COG0484	heat shock protein binding
AV939_08195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AV939_08200	COG0784	Response regulator, receiver
AV939_08200	COG2205	protein histidine kinase activity
AV939_08210	COG4771	TonB-dependent receptor
AV939_08215	COG2610	gluconate transmembrane transporter activity
AV939_08220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AV939_08230	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_08240	COG0497	DNA recombination
AV939_08245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AV939_08250	COG0500	methyltransferase
AV939_08255	COG2733	membrane
AV939_08270	COG0110	maltose O-acetyltransferase activity
AV939_08275	COG0656	L-ascorbic acid biosynthetic process
AV939_08290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AV939_08295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AV939_08300	COG0009	L-threonylcarbamoyladenylate synthase
AV939_08305	COG0613	PHP domain protein
AV939_08310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AV939_08320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AV939_08325	COG0135	phosphoribosylanthranilate isomerase activity
AV939_08325	COG0134	indole-3-glycerol-phosphate synthase activity
AV939_08335	COG0159	tryptophan synthase activity
AV939_08340	COG2350	Protein conserved in bacteria
AV939_08355	COG0745	RESPONSE REGULATOR receiver
AV939_08360	COG2205	protein histidine kinase activity
AV939_08365	COG0628	permease
AV939_08370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AV939_08375	COG1090	epimerase
AV939_08380	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AV939_08385	COG4181	ATPase activity
AV939_08405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AV939_08435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AV939_08455	COG0745	RESPONSE REGULATOR receiver
AV939_08465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AV939_08470	COG5265	(ABC) transporter
AV939_08485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AV939_08495	COG4139	cobalamin transport
AV939_08500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV939_08515	COG2226	methyltransferase
AV939_08515	COG1073	alpha beta
AV939_08520	COG0156	8-amino-7-oxononanoate synthase activity
AV939_08545	COG0456	acetyltransferase
AV939_08550	COG0189	ligase activity
AV939_08565	COG0017	Asparaginyl-tRNA synthetase
AV939_08575	COG2995	paraquat-inducible protein a
AV939_08580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AV939_08580	COG3008	intermembrane lipid transfer
AV939_08590	COG3706	GGDEF domain
AV939_08610	COG0583	DNA-binding transcription factor activity
AV939_08615	COG1309	transcriptional regulator
AV939_08625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_08630	COG0517	IMP dehydrogenase activity
AV939_08645	COG0583	DNA-binding transcription factor activity
AV939_08650	COG3038	cytochrome b561
AV939_08660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV939_08690	COG2271	Major facilitator Superfamily
AV939_08695	COG2205	protein histidine kinase activity
AV939_08695	COG0784	Response regulator, receiver
AV939_08735	COG0024	Methionine aminopeptidase
AV939_08745	COG0745	RESPONSE REGULATOR receiver
AV939_08745	COG3706	GGDEF domain
AV939_08770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AV939_08790	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AV939_08795	COG2885	chlorophyll binding
AV939_08800	COG0823	Involved in the tonB-independent uptake of proteins
AV939_08815	COG0811	peptide transport
AV939_08820	COG0824	Thioesterase
AV939_08825	COG2255	four-way junction helicase activity
AV939_08840	COG0494	nUDIX hydrolase
AV939_08845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AV939_08860	COG2204	response regulator
AV939_08870	COG2205	protein histidine kinase activity
AV939_08890	COG0745	RESPONSE REGULATOR receiver
AV939_08890	COG3706	GGDEF domain
AV939_08900	COG0023	Translation Initiation Factor
AV939_08905	COG0745	RESPONSE REGULATOR receiver
AV939_08910	COG0077	Prephenate dehydratase
AV939_08910	COG1605	Chorismate mutase
AV939_08915	COG0840	transmembrane signaling receptor activity
AV939_08920	COG0287	Prephenate dehydrogenase
AV939_08920	COG1605	Chorismate mutase
AV939_08925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AV939_08930	COG2860	membrane
AV939_08945	COG0335	large ribosomal subunit rRNA binding
AV939_08950	COG0336	Belongs to the RNA methyltransferase TrmD family
AV939_08955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AV939_08960	COG0228	four-way junction DNA binding
AV939_08980	COG1132	(ABC) transporter
AV939_08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_08995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AV939_09025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AV939_09030	COG4137	Cytochrome C assembly protein
AV939_09035	COG4536	flavin adenine dinucleotide binding
AV939_09045	COG2062	phosphohistidine phosphatase, SixA
AV939_09050	COG1025	Belongs to the peptidase M16 family
AV939_09065	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV939_09065	COG1024	Enoyl-CoA hydratase
AV939_09075	COG0714	Associated with various cellular activities
AV939_09095	COG2304	oxidoreductase activity
AV939_09120	COG3706	GGDEF domain
AV939_09125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_09130	COG0175	sulfate reduction
AV939_09135	COG0529	Catalyzes the synthesis of activated sulfate
AV939_09150	COG0471	metal ion transport
AV939_09150	COG3273	potassium ion transport
AV939_09175	COG0367	asparagine synthase
AV939_09185	COG0602	queuosine metabolic process
AV939_09210	COG0556	nucleotide-excision repair
AV939_09215	COG0534	Mate efflux family protein
AV939_09230	COG4657	Part of a membrane complex involved in electron transport
AV939_09235	COG2878	Part of a membrane complex involved in electron transport
AV939_09240	COG4656	Part of a membrane complex involved in electron transport
AV939_09245	COG4658	electron transport chain
AV939_09255	COG4660	Part of a membrane complex involved in electron transport
AV939_09260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AV939_09285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AV939_09290	COG1506	peptidase
AV939_09290	COG4946	Tricorn protease homolog
AV939_09290	COG0823	Involved in the tonB-independent uptake of proteins
AV939_09315	COG1278	Cold shock
AV939_09320	COG0346	lactoylglutathione lyase activity
AV939_09325	COG0584	glycerophosphoryl diester phosphodiesterase
AV939_09330	COG2885	chlorophyll binding
AV939_09335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AV939_09340	COG0450	alkyl hydroperoxide reductase
AV939_09365	COG4771	TonB-dependent receptor
AV939_09370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AV939_09380	COG2766	serine protein kinase
AV939_09385	COG2718	Belongs to the UPF0229 family
AV939_09390	COG2719	SpoVR family
AV939_09410	COG2890	protein-(glutamine-N5) methyltransferase activity
AV939_09415	COG2840	Smr protein MutS2
AV939_09440	COG1136	(ABC) transporter
AV939_09465	COG0612	Peptidase, M16
AV939_09475	COG0564	pseudouridine synthase activity
AV939_09480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AV939_09485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AV939_09510	COG2175	clavaminate synthase activity
AV939_09540	COG0583	DNA-binding transcription factor activity
AV939_09555	COG0456	acetyltransferase
AV939_09610	COG0848	biopolymer transport protein
AV939_09615	COG0811	peptide transport
AV939_09620	COG0811	peptide transport
AV939_09660	COG0457	Tetratricopeptide repeat
AV939_09685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AV939_09690	COG1522	sequence-specific DNA binding
AV939_09695	COG0625	glutathione transferase activity
AV939_09725	COG1842	Phage shock protein A
AV939_09730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AV939_09735	COG0747	negative chemotaxis
AV939_09740	COG4168	peptide transport system, permease
AV939_09745	COG4171	peptide transport system, permease
AV939_09750	COG4172	Belongs to the ABC transporter superfamily
AV939_09755	COG4172	Belongs to the ABC transporter superfamily
AV939_09760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AV939_09775	COG1607	acyl-coa hydrolase
AV939_09815	COG3590	peptidase
AV939_09820	COG1309	transcriptional regulator
AV939_09830	COG0659	secondary active sulfate transmembrane transporter activity
AV939_09835	COG0288	reversible hydration of carbon dioxide
AV939_09840	COG0583	DNA-binding transcription factor activity
AV939_09845	COG0583	DNA-binding transcription factor activity
AV939_09855	COG1410	methionine synthase
AV939_09855	COG0646	methionine synthase
AV939_09860	COG0646	methionine synthase
AV939_09860	COG1410	methionine synthase
AV939_09875	COG0835	chemotaxis
AV939_09885	COG1192	Involved in chromosome partitioning
AV939_09890	COG2201	protein-glutamate methylesterase activity
AV939_09895	COG0643	Histidine kinase
AV939_09895	COG2198	Histidine kinase
AV939_09900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AV939_09915	COG0455	bacterial-type flagellum organization
AV939_09925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AV939_09940	COG1987	bacterial-type flagellum assembly
AV939_09990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AV939_09995	COG1766	The M ring may be actively involved in energy transduction
AV939_10005	COG2204	response regulator
AV939_10010	COG3852	Histidine kinase
AV939_10015	COG2204	response regulator
AV939_10025	COG1086	Polysaccharide biosynthesis protein
AV939_10030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AV939_10035	COG1083	cytidylyl-transferase
AV939_10045	COG2089	acid synthase
AV939_10060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AV939_10100	COG2089	acid synthase
AV939_10105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AV939_10110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AV939_10150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AV939_10155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AV939_10175	COG1256	bacterial-type flagellum assembly
AV939_10180	COG1705	Flagellar rod assembly protein muramidase FlgJ
AV939_10180	COG3951	Flagellar rod assembly protein muramidase FlgJ
AV939_10195	COG4786	Flagellar basal body rod
AV939_10200	COG4787	bacterial-type flagellum-dependent cell motility
AV939_10205	COG1749	Flagellar hook protein flgE
AV939_10210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AV939_10215	COG1558	bacterial-type flagellum-dependent cell motility
AV939_10220	COG1815	bacterial-type flagellum-dependent cell motility
AV939_10225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AV939_10230	COG0835	chemotaxis
AV939_10230	COG0784	Response regulator, receiver
AV939_10270	COG2197	response regulator
AV939_10275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_10285	COG2885	chlorophyll binding
AV939_10390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_10390	COG2205	protein histidine kinase activity
AV939_10400	COG0205	6-phosphofructokinase activity
AV939_10405	COG3279	Response regulator of the LytR AlgR family
AV939_10410	COG3275	phosphorelay sensor kinase activity
AV939_10440	COG3081	Nucleoid-associated protein
AV939_10445	COG3082	Protein of unknown function (DUF1414)
AV939_10450	COG3083	sulfuric ester hydrolase activity
AV939_10460	COG2226	methyltransferase
AV939_10465	COG1024	Enoyl-CoA hydratase
AV939_10470	COG1960	acyl-CoA dehydrogenase activity
AV939_10480	COG2084	Dehydrogenase
AV939_10485	COG0386	Belongs to the glutathione peroxidase family
AV939_10490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AV939_10495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AV939_10500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AV939_10525	COG0616	signal peptide processing
AV939_10535	COG2267	carboxylic ester hydrolase activity
AV939_10540	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_10550	COG1609	Transcriptional regulator
AV939_10565	COG0366	Alpha amylase catalytic
AV939_10585	COG4667	esterase of the alpha-beta hydrolase superfamily
AV939_10620	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV939_10625	COG0567	Dehydrogenase, E1 component
AV939_10635	COG1053	succinate dehydrogenase
AV939_10640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AV939_10645	COG2009	succinate dehydrogenase
AV939_10665	COG0435	Glutathione S-transferase
AV939_10670	COG0579	oxidoreductase
AV939_10675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AV939_10715	COG1663	tetraacyldisaccharide 4'-kinase activity
AV939_10720	COG1132	(ABC) transporter
AV939_10735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AV939_10745	COG1196	nuclear chromosome segregation
AV939_10765	COG0295	cytidine deaminase activity
AV939_10790	COG0477	Major facilitator Superfamily
AV939_10810	COG2318	DinB family
AV939_10815	COG0457	Tetratricopeptide repeat
AV939_10825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AV939_10835	COG2914	Belongs to the UPF0125 (RnfH) family
AV939_10840	COG2867	negative regulation of translational initiation
AV939_10880	COG0582	viral genome integration into host DNA
AV939_10905	COG4771	TonB-dependent receptor
AV939_10910	COG2814	Major facilitator Superfamily
AV939_10940	COG1012	belongs to the aldehyde dehydrogenase family
AV939_10950	COG1595	DNA-templated transcription, initiation
AV939_10980	COG0583	DNA-binding transcription factor activity
AV939_11000	COG5001	Diguanylate cyclase
AV939_11000	COG3300	MHYT domain
AV939_11015	COG5001	Diguanylate cyclase
AV939_11015	COG4251	negative regulation of phosphorylation
AV939_11015	COG3706	GGDEF domain
AV939_11015	COG2203	Gaf domain
AV939_11030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AV939_11035	COG4136	ATPase activity
AV939_11040	COG4135	transport system, permease component
AV939_11045	COG4134	Bacterial extracellular solute-binding protein
AV939_11060	COG4771	TonB-dependent receptor
AV939_11075	COG1032	radical SAM domain protein
AV939_11100	COG4774	siderophore transport
AV939_11110	COG0450	alkyl hydroperoxide reductase
AV939_11135	COG3153	acetyltransferase
AV939_11135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV939_11145	COG0596	Alpha beta hydrolase
AV939_11150	COG3706	GGDEF domain
AV939_11160	COG4269	membrane
AV939_11170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AV939_11185	COG0195	Participates in both transcription termination and antitermination
AV939_11195	COG3437	response regulator, receiver
AV939_11200	COG0784	Response regulator, receiver
AV939_11200	COG2198	Histidine kinase
AV939_11200	COG2205	protein histidine kinase activity
AV939_11220	COG4771	TonB-dependent receptor
AV939_11225	COG0668	transmembrane transport
AV939_11245	COG0668	transmembrane transport
AV939_11265	COG0246	Mannitol dehydrogenase
AV939_11275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_11280	COG2390	Transcriptional regulator
AV939_11390	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_11430	COG3268	Saccharopine dehydrogenase
AV939_11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AV939_11460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AV939_11465	COG1074	ATP-dependent DNA helicase activity
AV939_11470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AV939_11480	COG1022	Amp-dependent synthetase and ligase
AV939_11485	COG5001	Diguanylate cyclase
AV939_11485	COG3300	MHYT domain
AV939_11510	COG0583	DNA-binding transcription factor activity
AV939_11530	COG0640	Transcriptional regulator
AV939_11540	COG0583	DNA-binding transcription factor activity
AV939_11550	COG2204	response regulator
AV939_11560	COG4251	negative regulation of phosphorylation
AV939_11565	COG0784	Response regulator, receiver
AV939_11595	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AV939_11620	COG3139	Protein of unknown function (DUF1315)
AV939_11630	COG1115	amino acid carrier protein
AV939_11635	COG2866	Carboxypeptidase
AV939_11655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AV939_11665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AV939_11670	COG1640	4-alpha-glucanotransferase
AV939_11680	COG0676	glucose-6-phosphate 1-epimerase activity
AV939_11685	COG0800	Aldolase
AV939_11695	COG0129	dihydroxy-acid dehydratase activity
AV939_11705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AV939_11710	COG1737	Transcriptional regulator
AV939_11715	COG0469	pyruvate kinase activity
AV939_11720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AV939_11765	COG2205	protein histidine kinase activity
AV939_11770	COG0745	RESPONSE REGULATOR receiver
AV939_11795	COG3665	Urea carboxylase-associated protein
AV939_11805	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_11810	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AV939_11835	COG2721	sulfolactate sulfo-lyase activity
AV939_11840	COG1904	glucuronate isomerase
AV939_11845	COG0246	Mannitol dehydrogenase
AV939_11850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_11855	COG2755	lipolytic protein G-D-S-L family
AV939_11865	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AV939_11875	COG4677	pectinesterase activity
AV939_11880	COG3850	Histidine kinase
AV939_11880	COG2205	protein histidine kinase activity
AV939_11880	COG3437	response regulator, receiver
AV939_11880	COG4999	Histidine kinase
AV939_11895	COG2356	endonuclease I
AV939_11905	COG1024	Enoyl-CoA hydratase
AV939_11925	COG1609	Transcriptional regulator
AV939_11930	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_11935	COG0673	inositol 2-dehydrogenase activity
AV939_11965	COG0746	molybdenum cofactor guanylyltransferase activity
AV939_11975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AV939_11980	COG1764	response to oxidative stress
AV939_11995	COG3706	GGDEF domain
AV939_12005	COG0745	RESPONSE REGULATOR receiver
AV939_12010	COG5002	protein histidine kinase activity
AV939_12010	COG3850	Histidine kinase
AV939_12040	COG1957	nucleoside hydrolase
AV939_12045	COG0738	Major facilitator superfamily
AV939_12070	COG0840	transmembrane signaling receptor activity
AV939_12080	COG0753	catalase activity
AV939_12090	COG0330	HflC and HflK could
AV939_12110	COG0778	Nitroreductase
AV939_12130	COG0471	metal ion transport
AV939_12140	COG0489	protein tyrosine kinase activity
AV939_12145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_12145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_12150	COG2226	methyltransferase
AV939_12155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_12160	COG1388	LysM domain
AV939_12160	COG0741	lytic transglycosylase activity
AV939_12180	COG2942	2-epimerase
AV939_12185	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AV939_12195	COG1609	Transcriptional regulator
AV939_12200	COG2942	2-epimerase
AV939_12205	COG3119	arylsulfatase activity
AV939_12220	COG4124	Belongs to the glycosyl hydrolase 26 family
AV939_12255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AV939_12265	COG1785	Belongs to the alkaline phosphatase family
AV939_12270	COG1785	Belongs to the alkaline phosphatase family
AV939_12285	COG2268	Band 7 protein
AV939_12305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AV939_12310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AV939_12315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AV939_12320	COG2080	2 iron, 2 sulfur cluster binding
AV939_12330	COG0604	alcohol dehydrogenase
AV939_12340	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AV939_12365	COG0084	hydrolase, TatD family'
AV939_12385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AV939_12390	COG1286	toxin biosynthetic process
AV939_12395	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AV939_12400	COG0285	dihydrofolate synthase activity
AV939_12410	COG0101	tRNA pseudouridine synthase activity
AV939_12425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AV939_12445	COG3706	GGDEF domain
AV939_12450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AV939_12450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AV939_12480	COG3101	peptidyl-lysine hydroxylation
AV939_12525	COG1902	pentaerythritol trinitrate reductase activity
AV939_12525	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV939_12550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AV939_12555	COG1309	transcriptional regulator
AV939_12560	COG4399	Belongs to the UPF0754 family
AV939_12595	COG2186	Transcriptional regulator
AV939_12605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AV939_12610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AV939_12615	COG2983	Belongs to the UPF0260 family
AV939_12620	COG0179	Fumarylacetoacetate (FAA) hydrolase
AV939_12635	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AV939_12640	COG0318	PFAM AMP-dependent synthetase and ligase
AV939_12645	COG2267	carboxylic ester hydrolase activity
AV939_12660	COG1214	PFAM Peptidase M22, glycoprotease
AV939_12665	COG1199	ATP-dependent helicase activity
AV939_12725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AV939_12730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AV939_12735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AV939_12740	COG0131	Imidazoleglycerol-phosphate dehydratase
AV939_12740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AV939_12745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AV939_12760	COG0140	phosphoribosyl-ATP diphosphatase activity
AV939_12760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AV939_12770	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_12780	COG1022	Amp-dependent synthetase and ligase
AV939_12800	COG0463	Glycosyl transferase, family 2
AV939_12820	COG0642	Histidine kinase
AV939_12825	COG0745	RESPONSE REGULATOR receiver
AV939_12830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_12835	COG0681	Belongs to the peptidase S26 family
AV939_12855	COG0326	Molecular chaperone. Has ATPase activity
AV939_12860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AV939_12885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AV939_12890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AV939_12900	COG3220	belongs to the UPF0276 family
AV939_12910	COG2319	Wd-40 repeat
AV939_12910	COG4249	Peptidase C14 caspase catalytic subunit p20
AV939_12925	COG4251	negative regulation of phosphorylation
AV939_12925	COG3706	GGDEF domain
AV939_12925	COG2203	Gaf domain
AV939_12925	COG5001	Diguanylate cyclase
AV939_12960	COG1183	phosphatidylcholine synthase activity
AV939_12980	COG0542	response to heat
AV939_12990	COG0564	pseudouridine synthase activity
AV939_13005	COG1595	DNA-templated transcription, initiation
AV939_13020	COG4221	oxidoreductase activity
AV939_13035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AV939_13045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AV939_13050	COG1722	exodeoxyribonuclease VII activity
AV939_13055	COG0142	geranyltranstransferase activity
AV939_13065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AV939_13070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AV939_13080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AV939_13095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV939_13095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV939_13110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AV939_13115	COG0488	(ABC) transporter
AV939_13125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AV939_13135	COG0560	Phosphoserine phosphatase
AV939_13145	COG0084	hydrolase, TatD family'
AV939_13165	COG0681	Belongs to the peptidase S26 family
AV939_13190	COG1595	DNA-templated transcription, initiation
AV939_13195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AV939_13210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AV939_13230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AV939_13290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AV939_13295	COG1047	Peptidyl-prolyl cis-trans
AV939_13305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AV939_13310	COG0196	riboflavin kinase activity
AV939_13315	COG0728	peptidoglycan biosynthetic process
AV939_13320	COG0268	Binds directly to 16S ribosomal RNA
AV939_13335	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_13340	COG0385	Bile acid
AV939_13365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AV939_13370	COG0776	regulation of translation
AV939_13375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AV939_13380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AV939_13385	COG0740	serine-type endopeptidase activity
AV939_13390	COG0544	peptidyl-prolyl cis-trans isomerase activity
AV939_13430	COG1720	tRNA m6t6A37 methyltransferase activity
AV939_13445	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AV939_13450	COG0123	including yeast histone deacetylase and acetoin utilization protein
AV939_13470	COG0516	GMP reductase activity
AV939_13470	COG0517	IMP dehydrogenase activity
AV939_13475	COG1570	exodeoxyribonuclease VII activity
AV939_13490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AV939_13495	COG2976	Protein conserved in bacteria
AV939_13520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AV939_13530	COG2166	iron-sulfur cluster assembly
AV939_13545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AV939_13550	COG0719	Fe-S assembly protein
AV939_13555	COG0396	ATPase activity
AV939_13560	COG0719	Fe-S assembly protein
AV939_13565	COG1104	cysteine desulfurase activity
AV939_13580	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AV939_13585	COG0483	inositol monophosphate 1-phosphatase activity
AV939_13615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV939_13620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV939_13625	COG1862	Preprotein translocase
AV939_13630	COG0343	queuine tRNA-ribosyltransferase activity
AV939_13645	COG3789	protein conserved in bacteria
AV939_13650	COG1842	Phage shock protein A
AV939_13675	COG0754	glutathionylspermidine amidase activity
AV939_13690	COG2066	Belongs to the glutaminase family
AV939_13695	COG1785	Belongs to the alkaline phosphatase family
AV939_13750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AV939_13755	COG1045	serine acetyltransferase
AV939_13780	COG0438	transferase activity, transferring glycosyl groups
AV939_13825	COG0463	Glycosyl transferase, family 2
AV939_13825	COG1216	Glycosyl transferase, family 2
AV939_13860	COG0489	protein tyrosine kinase activity
AV939_13870	COG3267	Type II secretory pathway component ExeA
AV939_13870	COG3409	Peptidoglycan-binding domain 1 protein
AV939_13875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AV939_13875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AV939_13880	COG2827	Endonuclease containing a URI domain
AV939_13900	COG1560	Kdo2-lipid A biosynthetic process
AV939_13930	COG1960	acyl-CoA dehydrogenase activity
AV939_13945	COG1435	thymidine kinase activity
AV939_13955	COG1609	Transcriptional regulator
AV939_13960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AV939_14000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AV939_14005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV939_14010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AV939_14015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AV939_14040	COG0515	serine threonine protein kinase
AV939_14040	COG2815	serine threonine protein kinase
AV939_14075	COG4774	siderophore transport
AV939_14090	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_14105	COG4774	siderophore transport
AV939_14105	COG1629	transport
AV939_14110	COG4682	membrane
AV939_14125	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AV939_14130	COG0789	Transcriptional regulator
AV939_14145	COG0189	ligase activity
AV939_14160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AV939_14200	COG1960	acyl-CoA dehydrogenase activity
AV939_14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AV939_14240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AV939_14290	COG1607	acyl-coa hydrolase
AV939_14295	COG0826	peptidase U32
AV939_14360	COG0583	DNA-binding transcription factor activity
AV939_14375	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_14380	COG1733	regulation of RNA biosynthetic process
AV939_14395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AV939_14430	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_14440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AV939_14445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AV939_14460	COG0109	protoheme IX farnesyltransferase activity
AV939_14475	COG0583	DNA-binding transcription factor activity
AV939_14490	COG4221	oxidoreductase activity
AV939_14495	COG0693	protein deglycase activity
AV939_14550	COG1230	cation diffusion facilitator family transporter
AV939_14555	COG0789	Transcriptional regulator
AV939_14585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AV939_14590	COG1335	isochorismatase
AV939_14595	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AV939_14615	COG4771	TonB-dependent receptor
AV939_14650	COG1566	PFAM secretion protein HlyD family protein
AV939_14655	COG1846	Transcriptional regulator
AV939_14665	COG1295	ribonuclease BN
AV939_14675	COG0514	ATP-dependent DNA helicase (RecQ)
AV939_14680	COG4681	YaeQ
AV939_14700	COG0583	DNA-binding transcription factor activity
AV939_14710	COG0484	heat shock protein binding
AV939_14715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AV939_14715	COG1017	nitric oxide dioxygenase activity
AV939_14730	COG3604	Transcriptional regulator
AV939_14755	COG2319	Wd-40 repeat
AV939_14755	COG4249	Peptidase C14 caspase catalytic subunit p20
AV939_14770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AV939_14790	COG1451	nucleotide metabolic process
AV939_14805	COG0653	protein targeting
AV939_14840	COG2133	pyrroloquinoline quinone binding
AV939_14850	COG0697	spore germination
AV939_14855	COG3813	Protein conserved in bacteria
AV939_14860	COG0513	Belongs to the DEAD box helicase family
AV939_14910	COG2814	Major facilitator Superfamily
AV939_14920	COG0656	L-ascorbic acid biosynthetic process
AV939_14975	COG2801	Transposase and inactivated derivatives
AV939_15015	COG0583	DNA-binding transcription factor activity
AV939_15035	COG1621	beta-fructofuranosidase activity
AV939_15040	COG2814	Major facilitator Superfamily
AV939_15050	COG1629	transport
AV939_15050	COG4206	TonB-dependent receptor
AV939_15075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AV939_15080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AV939_15085	COG0006	proline dipeptidase activity
AV939_15100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_15105	COG1957	nucleoside hydrolase
AV939_15115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AV939_15120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AV939_15125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AV939_15145	COG3313	Fe-S protein
AV939_15185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV939_15190	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV939_15195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AV939_15200	COG2186	Transcriptional regulator
AV939_15225	COG4969	Belongs to the N-Me-Phe pilin family
AV939_15230	COG1459	type II secretion system
AV939_15240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AV939_15240	COG0237	dephospho-CoA kinase activity
AV939_15245	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AV939_15255	COG2988	succinylglutamate desuccinylase activity
AV939_15260	COG0494	nUDIX hydrolase
AV939_15270	COG0739	heme binding
AV939_15275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AV939_15285	COG0849	cell division
AV939_15290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AV939_15295	COG1181	Belongs to the D-alanine--D-alanine ligase family
AV939_15300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AV939_15310	COG0772	Belongs to the SEDS family
AV939_15315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AV939_15325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AV939_15330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AV939_15335	COG0768	penicillin binding
AV939_15340	COG3116	cell division
AV939_15350	COG2001	Belongs to the MraZ family
AV939_15390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AV939_15390	COG0678	peroxiredoxin activity
AV939_15395	COG3706	GGDEF domain
AV939_15395	COG2203	Gaf domain
AV939_15395	COG4251	negative regulation of phosphorylation
AV939_15395	COG5001	Diguanylate cyclase
AV939_15405	COG2204	response regulator
AV939_15410	COG0784	Response regulator, receiver
AV939_15410	COG2198	Histidine kinase
AV939_15410	COG5002	protein histidine kinase activity
AV939_15430	COG0668	transmembrane transport
AV939_15435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AV939_15440	COG0189	ligase activity
AV939_15445	COG1678	Uncharacterized ACR, COG1678
AV939_15450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AV939_15470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AV939_15475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AV939_15480	COG0762	integral membrane protein
AV939_15495	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV939_15495	COG1902	pentaerythritol trinitrate reductase activity
AV939_15510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_15515	COG0625	glutathione transferase activity
AV939_15545	COG0083	homoserine kinase activity
AV939_15555	COG0583	DNA-binding transcription factor activity
AV939_15565	COG2197	response regulator
AV939_15570	COG4585	Histidine kinase
AV939_15590	COG0640	Transcriptional regulator
AV939_15600	COG0431	NADPH-dependent FMN reductase
AV939_15605	COG0798	PFAM Bile acid sodium symporter
AV939_15610	COG2201	protein-glutamate methylesterase activity
AV939_15615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AV939_15620	COG0745	RESPONSE REGULATOR receiver
AV939_15625	COG5002	protein histidine kinase activity
AV939_15650	COG1748	Saccharopine dehydrogenase
AV939_15665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AV939_15670	COG3107	peptidoglycan biosynthetic process
AV939_15675	COG0792	nuclease activity
AV939_15685	COG2823	Periplasmic or secreted lipoprotein
AV939_15730	COG4585	Histidine kinase
AV939_15735	COG2197	response regulator
AV939_15740	COG4771	TonB-dependent receptor
AV939_15750	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AV939_15755	COG0372	Belongs to the citrate synthase family
AV939_15765	COG2828	Protein conserved in bacteria
AV939_15770	COG2203	Gaf domain
AV939_15770	COG2199	diguanylate cyclase activity
AV939_15815	COG2198	Histidine kinase
AV939_15815	COG0784	Response regulator, receiver
AV939_15815	COG5002	protein histidine kinase activity
AV939_15820	COG0070	glutamate synthase
AV939_15820	COG0069	glutamate synthase activity
AV939_15820	COG0067	glutamate synthase
AV939_15825	COG0493	'glutamate synthase
AV939_15835	COG1476	TRANSCRIPTIONal
AV939_15840	COG3866	Pectate lyase
AV939_15860	COG3866	Pectate lyase
AV939_15875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AV939_15890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AV939_15910	COG0739	heme binding
AV939_15915	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AV939_15925	COG0738	Major facilitator superfamily
AV939_15930	COG3659	wide pore channel activity
AV939_15935	COG1902	pentaerythritol trinitrate reductase activity
AV939_15945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AV939_15950	COG0625	glutathione transferase activity
AV939_15970	COG2894	cell division
AV939_15975	COG0850	regulation of cytokinetic process
AV939_16015	COG1914	H( )-stimulated, divalent metal cation uptake system
AV939_16020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AV939_16040	COG0174	glutamine synthetase
AV939_16050	COG3852	Histidine kinase
AV939_16060	COG3437	response regulator, receiver
AV939_16065	COG0204	Acyl-transferase
AV939_16080	COG3706	GGDEF domain
AV939_16095	COG0525	valine-tRNA ligase activity
AV939_16100	COG2927	DNA polymerase III (CHI subunit)
AV939_16105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AV939_16110	COG0795	lipopolysaccharide-transporting ATPase activity
AV939_16115	COG0795	lipopolysaccharide-transporting ATPase activity
AV939_16165	COG4264	IucA IucC family
AV939_16170	COG0318	PFAM AMP-dependent synthetase and ligase
AV939_16180	COG1082	Xylose isomerase domain protein TIM barrel
AV939_16265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AV939_16325	COG4191	Histidine kinase
AV939_16335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_16365	COG3706	GGDEF domain
AV939_16370	COG3706	GGDEF domain
AV939_16410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AV939_16415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AV939_16420	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AV939_16430	COG0535	radical SAM domain protein
AV939_16460	COG0784	Response regulator, receiver
AV939_16460	COG2205	protein histidine kinase activity
AV939_16470	COG0348	domain, Protein
AV939_16470	COG3901	Regulator of nitric oxide reductase transcription
AV939_16475	COG1012	belongs to the aldehyde dehydrogenase family
AV939_16480	COG2197	response regulator
AV939_16485	COG4585	Histidine kinase
AV939_16515	COG4771	TonB-dependent receptor
AV939_16520	COG1858	cytochrome C peroxidase
AV939_16550	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_16560	COG1917	Cupin 2, conserved barrel domain protein
AV939_16565	COG2271	Major facilitator Superfamily
AV939_16585	COG1716	ATPase activity
AV939_16620	COG1357	PFAM Pentapeptide repeats (8 copies)
AV939_16620	COG0515	serine threonine protein kinase
AV939_16635	COG1716	ATPase activity
AV939_16635	COG0842	Transport permease protein
AV939_16635	COG1131	(ABC) transporter
AV939_16640	COG0513	Belongs to the DEAD box helicase family
AV939_16645	COG0800	Aldolase
AV939_16650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_16655	COG2186	Transcriptional regulator
AV939_16665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AV939_16665	COG3264	Mechanosensitive ion channel
AV939_16700	COG3568	Endonuclease Exonuclease Phosphatase
AV939_16715	COG0730	response to heat
AV939_16735	COG4191	Histidine kinase
AV939_16745	COG0417	DNA replication proofreading
AV939_16795	COG1309	transcriptional regulator
AV939_16810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV939_16820	COG1573	uracil-dna glycosylase
AV939_16825	COG3300	MHYT domain
AV939_16825	COG5001	Diguanylate cyclase
AV939_16845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AV939_16850	COG4771	TonB-dependent receptor
AV939_16875	COG1842	Phage shock protein A
AV939_16885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AV939_16910	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AV939_16915	COG0204	Acyl-transferase
AV939_16920	COG0204	Acyl-transferase
AV939_16925	COG0668	transmembrane transport
AV939_16940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AV939_16945	COG0733	neurotransmitter:sodium symporter activity
AV939_16960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AV939_16975	COG0716	FMN binding
AV939_16985	COG0848	biopolymer transport protein
AV939_16995	COG0457	Tetratricopeptide repeat
AV939_17025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AV939_17030	COG0702	epimerase
AV939_17045	COG5002	protein histidine kinase activity
AV939_17045	COG5001	Diguanylate cyclase
AV939_17055	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AV939_17060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_17070	COG0583	DNA-binding transcription factor activity
AV939_17075	COG0121	glutamine amidotransferase
AV939_17090	COG1522	sequence-specific DNA binding
AV939_17105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_17115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AV939_17125	COG1477	protein flavinylation
AV939_17130	COG2871	sodium ion transport
AV939_17135	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AV939_17140	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AV939_17145	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AV939_17150	COG1805	sodium ion transport
AV939_17160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AV939_17165	COG0545	Peptidyl-prolyl cis-trans isomerase
AV939_17170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AV939_17180	COG0039	L-malate dehydrogenase activity
AV939_17185	COG1438	arginine binding
AV939_17215	COG0572	uridine kinase
AV939_17220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AV939_17235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AV939_17245	COG0745	RESPONSE REGULATOR receiver
AV939_17245	COG3706	GGDEF domain
AV939_17255	COG0517	IMP dehydrogenase activity
AV939_17255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AV939_17260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_17280	COG0189	ligase activity
AV939_17290	COG4067	protein conserved in archaea
AV939_17290	COG0189	ligase activity
AV939_17305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AV939_17320	COG1283	sodium-dependent phosphate transmembrane transporter activity
AV939_17325	COG0667	Aldo Keto reductase
AV939_17340	COG0753	catalase activity
AV939_17375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AV939_17380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AV939_17380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AV939_17385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AV939_17440	COG0583	DNA-binding transcription factor activity
AV939_17455	COG0438	transferase activity, transferring glycosyl groups
AV939_17455	COG1216	Glycosyl transferase, family 2
AV939_17485	COG1216	Glycosyl transferase, family 2
AV939_17490	COG1216	Glycosyl transferase, family 2
AV939_17500	COG1215	transferase activity, transferring glycosyl groups
AV939_17515	COG0110	maltose O-acetyltransferase activity
AV939_17525	COG1216	Glycosyl transferase, family 2
AV939_17540	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AV939_17540	COG0662	Cupin 2, conserved barrel domain protein
AV939_17550	COG0202	RNA polymerase activity
AV939_17570	COG0201	protein transport
AV939_17590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AV939_17625	COG5002	protein histidine kinase activity
AV939_17625	COG0784	Response regulator, receiver
AV939_17645	COG0557	exoribonuclease II activity
AV939_17660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AV939_17675	COG0543	2 iron, 2 sulfur cluster binding
AV939_17680	COG2234	aminopeptidase activity
AV939_17700	COG1271	oxidase subunit
AV939_17705	COG1294	oxidase, subunit
AV939_17710	COG0840	transmembrane signaling receptor activity
AV939_17715	COG1522	sequence-specific DNA binding
AV939_17730	COG1278	Cold shock
AV939_17735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AV939_17755	COG0339	signal peptide processing
AV939_17760	COG2201	protein-glutamate methylesterase activity
AV939_17770	COG4191	Histidine kinase
AV939_17770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_17780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV939_17785	COG0243	molybdopterin cofactor binding
AV939_17790	COG0793	Belongs to the peptidase S41A family
AV939_17790	COG4946	Tricorn protease homolog
AV939_17830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AV939_17835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AV939_17840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AV939_17855	COG0281	malic enzyme
AV939_17860	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AV939_17865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AV939_17895	COG0456	acetyltransferase
AV939_17905	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AV939_17910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AV939_17915	COG2177	Part of the ABC transporter FtsEX involved in
AV939_17920	COG2884	Cell division ATP-binding protein ftsE
AV939_17925	COG0552	protein localization to endoplasmic reticulum
AV939_17930	COG0742	ribosomal rna small subunit methyltransferase
AV939_17940	COG2095	MarC family integral membrane protein
AV939_17960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AV939_17965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AV939_17975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AV939_17990	COG0076	glutamate decarboxylase activity
AV939_17995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AV939_18005	COG0842	Transport permease protein
AV939_18010	COG1131	(ABC) transporter
AV939_18015	COG0745	RESPONSE REGULATOR receiver
AV939_18020	COG2205	protein histidine kinase activity
AV939_18025	COG4774	siderophore transport
AV939_18045	COG1253	flavin adenine dinucleotide binding
AV939_18050	COG0701	Predicted permease
AV939_18055	COG1966	Carbon starvation protein
AV939_18110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AV939_18115	COG0049	tRNA binding
AV939_18120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AV939_18125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AV939_18130	COG0085	RNA polymerase activity
AV939_18135	COG0222	ribosome binding
AV939_18140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AV939_18145	COG0081	regulation of translation
AV939_18150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AV939_18155	COG0250	Participates in transcription elongation, termination and antitermination
AV939_18160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AV939_18170	COG1132	(ABC) transporter
AV939_18175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AV939_18180	COG3590	peptidase
AV939_18190	COG0513	Belongs to the DEAD box helicase family
AV939_18195	COG0418	dihydroorotase activity
AV939_18205	COG3040	lipid binding
AV939_18210	COG4989	oxidoreductase activity
AV939_18215	COG0346	lactoylglutathione lyase activity
AV939_18230	COG0302	gtp cyclohydrolase
AV939_18250	COG2957	Belongs to the agmatine deiminase family
AV939_18255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV939_18270	COG3306	glycosyltransferase involved in LPS biosynthesis
AV939_18275	COG1201	RNA secondary structure unwinding
AV939_18285	COG1793	dna ligase
AV939_18295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_18310	COG0625	glutathione transferase activity
AV939_18325	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AV939_18330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AV939_18340	COG1012	belongs to the aldehyde dehydrogenase family
AV939_18355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AV939_18360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AV939_18365	COG0330	HflC and HflK could
AV939_18370	COG0330	HflC and HflK could
AV939_18375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AV939_18380	COG1923	regulation of RNA biosynthetic process
AV939_18385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AV939_18400	COG0802	atpase or kinase
AV939_18405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AV939_18405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AV939_18410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AV939_18420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AV939_18425	COG2816	NAD+ diphosphatase activity
AV939_18430	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AV939_18435	COG0735	belongs to the Fur family
AV939_18445	COG0432	Pfam Uncharacterised protein family UPF0047
AV939_18455	COG0305	Participates in initiation and elongation during chromosome replication
AV939_18480	COG2258	MOSC domain
AV939_18510	COG5002	protein histidine kinase activity
AV939_18520	COG0840	transmembrane signaling receptor activity
AV939_18525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_18525	COG4191	Histidine kinase
AV939_18535	COG1609	Transcriptional regulator
AV939_18540	COG2211	Major facilitator Superfamily
AV939_18545	COG2723	6-phospho-beta-galactosidase activity
AV939_18555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AV939_18560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV939_18565	COG4558	Periplasmic binding protein
AV939_18575	COG4206	TonB-dependent receptor
AV939_18585	COG1472	Belongs to the glycosyl hydrolase 3 family
AV939_18600	COG2855	membrane
AV939_18605	COG2175	clavaminate synthase activity
AV939_18610	COG0656	L-ascorbic acid biosynthetic process
AV939_18630	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_18635	COG1230	cation diffusion facilitator family transporter
AV939_18670	COG4771	TonB-dependent receptor
AV939_18675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AV939_18680	COG4988	ABC transporter
AV939_18690	COG1294	oxidase, subunit
AV939_18705	COG2204	response regulator
AV939_18740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AV939_18765	COG4319	ketosteroid isomerase
AV939_18805	COG3237	CsbD-like
AV939_18850	COG2267	carboxylic ester hydrolase activity
AV939_18875	COG3038	cytochrome b561
AV939_18880	COG2353	YceI-like domain
AV939_18885	COG1252	NADH dehydrogenase
AV939_18915	COG2130	NADP-dependent
AV939_18920	COG3706	GGDEF domain
AV939_18920	COG5001	Diguanylate cyclase
AV939_18920	COG4251	negative regulation of phosphorylation
AV939_18920	COG2203	Gaf domain
AV939_18940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV939_18950	COG4181	ATPase activity
AV939_18970	COG0523	cobalamin synthesis protein
AV939_18985	COG4771	TonB-dependent receptor
AV939_18990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AV939_19015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AV939_19020	COG1349	DNA-binding transcription factor activity
AV939_19035	COG0697	spore germination
AV939_19040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AV939_19045	COG4977	sequence-specific DNA binding
AV939_19055	COG1166	arginine decarboxylase activity
AV939_19065	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AV939_19070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AV939_19075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AV939_19085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AV939_19095	COG0523	cobalamin synthesis protein
AV939_19125	COG4232	protein-disulfide reductase activity
AV939_19130	COG0739	heme binding
AV939_19135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AV939_19140	COG0511	ligase activity, forming carbon-carbon bonds
AV939_19145	COG0439	Biotin carboxylase
AV939_19165	COG2176	DNA-directed DNA polymerase activity
AV939_19185	COG0154	amidase activity
AV939_19200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AV939_19205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AV939_19220	COG0151	Belongs to the GarS family
AV939_19230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AV939_19240	COG3954	Phosphoribulokinase
AV939_19245	COG2233	PERMEase
AV939_19260	COG0745	RESPONSE REGULATOR receiver
AV939_19280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AV939_19290	COG3031	protein transport across the cell outer membrane
AV939_19300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AV939_19305	COG1459	type II secretion system
AV939_19310	COG2165	general secretion pathway protein
AV939_19320	COG2165	general secretion pathway protein
AV939_19325	COG4795	General secretion pathway protein
AV939_19330	COG3156	type II secretion system protein K
AV939_19340	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AV939_19350	COG1234	tRNA 3'-trailer cleavage
AV939_19355	COG1012	belongs to the aldehyde dehydrogenase family
AV939_19365	COG1011	Hydrolase
AV939_19370	COG0494	nUDIX hydrolase
AV939_19375	COG1218	3'(2'),5'-bisphosphate nucleotidase
AV939_19390	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AV939_19400	COG3089	Belongs to the UPF0270 family
AV939_19405	COG0429	hydrolase of the alpha beta-hydrolase fold
AV939_19415	COG0488	(ABC) transporter
AV939_19440	COG0545	Peptidyl-prolyl cis-trans isomerase
AV939_19450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AV939_19455	COG2183	response to ionizing radiation
AV939_19470	COG0596	Alpha beta hydrolase
AV939_19475	COG1040	competence protein
AV939_19495	COG1794	racemase activity, acting on amino acids and derivatives
AV939_19510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AV939_19515	COG0534	Mate efflux family protein
AV939_19530	COG1999	signal sequence binding
AV939_19535	COG0109	protoheme IX farnesyltransferase activity
AV939_19540	COG1612	heme a metabolic process
AV939_19565	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AV939_19570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AV939_19575	COG1565	acr, cog1565
AV939_19575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AV939_19605	COG0129	dihydroxy-acid dehydratase activity
AV939_19610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AV939_19620	COG0606	chelatase, subunit chli
AV939_19625	COG0583	DNA-binding transcription factor activity
AV939_19635	COG2814	Major facilitator Superfamily
AV939_19645	COG0729	surface antigen
AV939_19650	COG2911	Protein conserved in bacteria
AV939_19675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AV939_19685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AV939_19705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AV939_19755	COG0425	Belongs to the sulfur carrier protein TusA family
AV939_19770	COG1561	YicC-like family, N-terminal region
AV939_19805	COG2211	Major facilitator Superfamily
AV939_19810	COG1609	Transcriptional regulator
AV939_19825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AV939_19825	COG2199	diguanylate cyclase activity
AV939_19855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AV939_19875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AV939_19880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AV939_19900	COG1475	DNA binding
AV939_19905	COG1192	Involved in chromosome partitioning
AV939_19930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AV939_19935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AV939_19945	COG0706	membrane insertase activity
AV939_19950	COG0594	ribonuclease P activity
AV939_19955	COG0230	Belongs to the bacterial ribosomal protein bL34 family