locus-tag class description DS731_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DS731_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DS731_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DS731_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DS731_00035 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DS731_00040 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit DS731_00045 ENOG4108R3E Dna-3-methyladenine glycosylase i DS731_00055 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) DS731_00065 ENOG4106RE7 Cytochrome DS731_00070 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DS731_00075 ENOG4105C2M dna polymerase I DS731_00080 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain DS731_00085 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) DS731_00090 ENOG4105C1A potassium transporter peripheral membrane DS731_00095 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DS731_00105 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DS731_00110 ENOG4108WZM domain protein DS731_00115 ENOG4105C79 DNA protecting protein DprA DS731_00120 ENOG4108RPN Protein smg homolog DS731_00125 ENOG4108WI1 Dna topoisomerase DS731_00130 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DS731_00135 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) DS731_00140 ENOG4105EIF outer membrane protein W DS731_00150 ENOG4105E2X shikimate dehydrogenase DS731_00155 ENOG4108Z0R Transferase DS731_00205 ENOG41061N2 exported protein DS731_00210 ENOG4105C0B DNA polymerase III (alpha subunit) DS731_00245 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) DS731_00250 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DS731_00255 ENOG4105W5Q DNA repair protein (RadC DS731_00275 ENOG4105E3R (LipO)protein DS731_00280 ENOG4105KDC 50s ribosomal protein l28 DS731_00285 ENOG4105W0E 50S ribosomal protein L33 DS731_00295 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DS731_00300 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DS731_00305 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) DS731_00310 ENOG4105DKP glycosyl transferase, family 9 DS731_00325 ENOG4105BZU Histidine kinase DS731_00330 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DS731_00335 ENOG4105CPQ Dehydrogenase DS731_00340 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DS731_00355 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) DS731_00360 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) DS731_00365 ENOG4105W0Z cytoplasmic protein DS731_00370 ENOG4105C4R Atp-dependent dna helicase DS731_00375 ENOG4105BZU Histidine kinase DS731_00380 ENOG4105MPD Cytochrome DS731_00400 ENOG4107RA4 Glycosyl transferase (Group 1 DS731_00405 ENOG4105PSV Polysaccharide Biosynthesis Protein DS731_00470 ENOG4105C9U ATP-dependent DNA helicase RecQ DS731_00495 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DS731_00515 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DS731_00600 ENOG4105CF7 AraC family transcriptional regulator DS731_00605 ENOG4105EQ2 LysR family Transcriptional regulator DS731_00610 ENOG4107RTG Major Facilitator superfamily DS731_00615 ENOG4105BZU Histidine kinase DS731_00635 ENOG4107ZSV Receptor DS731_00640 ENOG4105CNT hydrolase family 2 DS731_00650 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DS731_00695 ENOG4105C9F isomerase DS731_00700 ENOG4105DMF Dehydrogenase DS731_00705 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) DS731_00745 ENOG4105DVH amino acid DS731_00765 ENOG4105MKU Transcriptional regulator DS731_00845 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DS731_00850 ENOG4105CHR reductase DS731_00865 ENOG4108KEZ Dehydrogenase DS731_00880 ENOG4108SC4 )-transporter DS731_00885 ENOG4105CHR reductase DS731_00895 ENOG4108KEZ Dehydrogenase DS731_00905 ENOG41061H0 Monooxygenase DS731_00965 ENOG4105EBR Carboxylesterase DS731_00975 ENOG4108Z6Z Transcriptional regulator DS731_00990 ENOG4105H3G oxidoreductase DS731_01025 ENOG4107U9B transcriptional regulator DS731_01030 ENOG4105C58 cytochrome c oxidase accessory protein ccog DS731_01035 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DS731_01040 ENOG4105C4M (Ubiquinol oxidase) subunit I DS731_01045 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DS731_01105 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DS731_01115 ENOG4105D05 Receptor DS731_01120 ENOG4105HEI LysR family (Transcriptional regulator DS731_01125 ENOG4105KPY Small multidrug resistance protein DS731_01140 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DS731_01160 ENOG41061H0 Monooxygenase DS731_01170 ENOG4105E0K tonB-dependent siderophore receptor DS731_01175 ENOG4105R0I Feruloyl esterase DS731_01185 ENOG4105D2S major facilitator superfamily DS731_01190 ENOG4105HEI LysR family (Transcriptional regulator DS731_01195 ENOG4105CT4 transporter DS731_01200 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DS731_01205 ENOG4107VG4 Xylose isomerase domain protein TIM barrel DS731_01215 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DS731_01230 ENOG4105CBG Sulfatase DS731_01235 ENOG4105C6F GntR Family Transcriptional Regulator DS731_01240 ENOG4108N3W hemolysin secretion protein DS731_01255 ENOG4107RNH Outer membrane receptor FepA DS731_01265 ENOG4105CNM Receptor DS731_01280 ENOG41076HS cation diffusion facilitator family transporter DS731_01295 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component DS731_01300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DS731_01305 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DS731_01350 ENOG4108VEQ Superoxide dismutase DS731_01360 ENOG4105BZU Histidine kinase DS731_01365 ENOG4105C9Q fumarate hydratase class II DS731_01375 ENOG41090JD Blue (Type 1) copper domain protein DS731_01380 ENOG4105DUM transcriptional regulator, lysR family DS731_01385 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DS731_01390 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase DS731_01405 ENOG4105ERH Fumarylacetoacetate hydrolase DS731_01415 ENOG4105EB3 Histidine kinase DS731_01420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DS731_01425 ENOG4105C1P efflux transporter, rnd family, mfp subunit DS731_01430 ENOG4105BZS acriflavin resistance protein DS731_01460 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_01465 ENOG4108R6W Transcriptional regulator, ARAC family DS731_01470 ENOG4105GAK amidohydrolase 2 DS731_01480 ENOG4105CPC Aldo Keto reductase DS731_01495 ENOG4105ENH Sulfatase DS731_01525 ENOG4108ZHJ Organic hydroperoxide resistance protein DS731_01530 ENOG4105K56 Transcriptional regulator DS731_01535 ENOG4108N3W hemolysin secretion protein DS731_01550 ENOG4105CXG d-lactate dehydrogenase DS731_01555 ENOG4106IUH DTW domain containing protein DS731_01575 ENOG4105Y49 secretion protein, HlyD family DS731_01580 ENOG4105DSW Fusaric acid resistance protein DS731_01585 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DS731_01605 ENOG4105CE4 GlcNAc 6-P deacetylase DS731_01610 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DS731_01615 ENOG4105RD7 BadF BadG BcrA BcrD DS731_01625 ENOG4105ETE Transcriptional regulator (LacI family DS731_01640 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DS731_01650 ENOG4105C6Z Gluconate DS731_01655 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family DS731_01660 ENOG4105DIQ Transcriptional regulator DS731_01675 ENOG4105CM6 amino acid regulated cytosolic protein DS731_01685 ENOG4105D64 Mechanosensitive ion channel DS731_01705 ENOG4107QJE Chromosome Partitioning Protein DS731_01730 ENOG4105CPK Glycosyl transferase (Group 1 DS731_01755 ENOG4108R1E Serine threonine protein phosphatase 1 DS731_01760 ENOG4105NBK UPF0345 protein DS731_01785 ENOG4105E4I Glycoside hydrolase family 28 DS731_01790 ENOG4105F5H Glycosyl Hydrolase Family 88 DS731_01795 ENOG4105D05 Receptor DS731_01800 ENOG4107TDE lipolytic protein G-D-S-L family DS731_01810 ENOG4105D05 Receptor DS731_01830 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DS731_01835 ENOG4108UHU Aldolase DS731_01840 ENOG4105DEI Mannitol dehydrogenase DS731_01845 ENOG4105D2H Uronic isomerase DS731_01850 ENOG4105CTX dehydratase DS731_01860 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DS731_01865 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter DS731_01870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DS731_01880 ENOG4105CHR reductase DS731_01890 ENOG4105D41 biosynthesis protein thiH DS731_01905 ENOG4105CUZ uba thif-type nad fad binding protein DS731_01910 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DS731_01915 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DS731_01925 ENOG4105CE1 Ferrous iron transport protein b DS731_01945 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DS731_01955 ENOG4105ECF c-methyltransferase DS731_01960 ENOG41076E6 Uroporphyrinogen-III Synthase DS731_01965 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DS731_01975 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DS731_01980 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) DS731_01985 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DS731_01990 ENOG4105KME endoribonuclease L-psp DS731_02000 ENOG4105CB5 ATP-dependent DNA helicase recG DS731_02005 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) DS731_02015 ENOG41086KC Transcriptional regulator DS731_02020 ENOG4105CBX hi0933 family DS731_02040 ENOG4105WD1 Membrane DS731_02045 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DS731_02050 ENOG4108IG5 Transcriptional regulator DS731_02055 ENOG4105C1P efflux transporter, rnd family, mfp subunit DS731_02060 ENOG4105BZS acriflavin resistance protein DS731_02065 ENOG4105CYC Transferase DS731_02080 ENOG4108N3W hemolysin secretion protein DS731_02100 ENOG4108NST exported protein DS731_02105 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DS731_02110 ENOG4105BZU Histidine kinase DS731_02120 ENOG4105CNG UPF0061 protein DS731_02130 ENOG4105C9U ATP-dependent DNA helicase RecQ DS731_02135 ENOG4105CJW magnesium transporter DS731_02140 ENOG4105FR1 rard protein DS731_02145 ENOG4105BZU Histidine kinase DS731_02150 ENOG4105C4R Atp-dependent dna helicase DS731_02160 ENOG4107U9T Pfam:Ribonuclease_BN DS731_02165 ENOG4105VDW Csbd family DS731_02170 ENOG4105D7W serine acetyltransferase DS731_02175 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant DS731_02180 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_02190 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DS731_02195 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DS731_02210 ENOG4105YVM Phosphoesterase, PA-phosphatase related DS731_02215 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) DS731_02225 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DS731_02230 ENOG4105DFU Cell wall formation (By similarity) DS731_02235 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 DS731_02240 ENOG4105F0N pyrophosphate phospho-hydrolase DS731_02245 ENOG4105BZU Histidine kinase DS731_02250 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor DS731_02260 ENOG4105KT5 UmuD protein DS731_02265 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DS731_02280 ENOG4105CC0 LysR family Transcriptional regulator DS731_02295 ENOG4105BZU Histidine kinase DS731_02300 ENOG4106UX7 integral membrane protein DS731_02305 ENOG4105HEI LysR family (Transcriptional regulator DS731_02315 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DS731_02320 ENOG4105BZU Histidine kinase DS731_02330 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DS731_02340 ENOG4107QHF type ii secretion system protein e DS731_02350 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DS731_02355 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DS731_02360 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DS731_02365 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DS731_02370 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DS731_02375 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DS731_02380 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DS731_02385 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DS731_02390 ENOG41083MP 50s ribosomal protein l29 DS731_02395 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DS731_02425 ENOG4105CDU Replicative dna helicase DS731_02430 ENOG4105CDV Ompa motb domain protein DS731_02435 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DS731_02445 ENOG4105MYN Zinc uptake regulation protein DS731_02455 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DS731_02465 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DS731_02470 ENOG4105K8N protein family UPF0079, ATPase DS731_02475 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DS731_02480 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DS731_02485 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DS731_02490 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DS731_02495 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DS731_02500 ENOG4107QJR hflk protein DS731_02505 ENOG4105EPW hflc protein DS731_02510 ENOG4105CFC Transporter DS731_02515 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DS731_02525 ENOG4105C7K acetolactate synthase DS731_02535 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DS731_02545 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DS731_02550 ENOG4105C2N RNA methyltransferase TrmH family group 3 DS731_02555 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_02565 ENOG4105BZU Histidine kinase DS731_02570 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DS731_02575 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DS731_02580 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DS731_02585 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DS731_02590 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DS731_02595 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DS731_02600 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DS731_02605 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DS731_02610 ENOG4105VPB 50S ribosomal protein L30 DS731_02615 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DS731_02620 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DS731_02625 ENOG41067V7 50S ribosomal protein L36 DS731_02630 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DS731_02635 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DS731_02640 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DS731_02645 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DS731_02650 ENOG4108ZT0 50S ribosomal protein l17 DS731_02705 ENOG4105K64 Glycosyl transferase, family 2 DS731_02720 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DS731_02730 ENOG4105C1B dTDP-glucose 4-6-dehydratase DS731_02775 ENOG4105D4A Cell wall formation (By similarity) DS731_02780 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase DS731_02785 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DS731_02810 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DS731_02825 ENOG4105BZU Histidine kinase DS731_02830 ENOG4105D22 carbon starvation protein DS731_02840 ENOG4105EB3 Histidine kinase DS731_02845 ENOG4105E3W Two component transcriptional regulator (Winged helix family DS731_02855 ENOG4105DA5 (ABC) transporter DS731_02860 ENOG4105E3A (ABC) transporter DS731_02865 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) DS731_02870 ENOG4105BZU Histidine kinase DS731_02875 ENOG4105DY8 decarboxylase DS731_02880 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DS731_02885 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DS731_02890 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DS731_02895 ENOG4105DJ0 Poly(A) Polymerase DS731_02900 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DS731_02905 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DS731_02910 ENOG4105PW4 Sugar fermentation stimulation protein homolog DS731_02915 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DS731_02925 ENOG41076UM multiple antibiotic resistance (MarC)-related protein DS731_02930 ENOG4105R2J Conserved Protein DS731_02935 ENOG4106H78 methyltransferase DS731_02940 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DS731_02945 ENOG4105CAK Cell division ATP-binding protein ftsE DS731_02950 ENOG4105CRP Part of the ABC transporter FtsEX involved in DS731_02955 ENOG4105D58 Diguanylate phosphodiesterase DS731_02960 ENOG4105D58 Diguanylate phosphodiesterase DS731_02965 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DS731_02975 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DS731_02985 ENOG4105SUU thioesterase domain DS731_02990 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DS731_03010 ENOG4107S2Z UPF0761 membrane protein DS731_03015 ENOG4105SYT Methylenetetrahydrofolate reductase DS731_03020 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) DS731_03025 ENOG4107SFI Major Facilitator superfamily DS731_03030 ENOG4105C6K Malic enzyme DS731_03035 ENOG4105VFB Binds the 23S rRNA (By similarity) DS731_03040 ENOG4105C25 Primosomal protein n' DS731_03055 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DS731_03060 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DS731_03065 ENOG4105HEI LysR family (Transcriptional regulator DS731_03070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DS731_03090 ENOG4105PFC Transcriptional regulator DS731_03115 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DS731_03135 ENOG4107RH7 Nicotinate phosphoribosyltransferase DS731_03145 ENOG4105DB4 DS731_03205 ENOG4105W1Y Transcriptional regulator DS731_03210 ENOG41063TF transcriptional regulator (AraC DS731_03235 ENOG4105DC8 reductase DS731_03240 ENOG4105BZU Histidine kinase DS731_03245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_03260 ENOG4107YTP response regulator receiver protein DS731_03265 ENOG4105BZU Histidine kinase DS731_03270 ENOG4105DGW oligopeptidase A DS731_03290 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DS731_03295 ENOG4105VEQ Cold shock protein DS731_03310 ENOG4105CHU acetyl-coa acetyltransferase DS731_03315 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DS731_03320 ENOG4107SC1 transglycosylase DS731_03325 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) DS731_03335 ENOG4105EAH synthase DS731_03340 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DS731_03345 ENOG4105K46 50S ribosomal protein l27 DS731_03350 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DS731_03360 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DS731_03365 ENOG4108K5P (LipO)protein DS731_03370 ENOG4108UM1 dedA family DS731_03375 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DS731_03380 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) DS731_03385 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) DS731_03395 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DS731_03400 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DS731_03410 ENOG4105C8Q Methyl-accepting chemotaxis DS731_03425 ENOG4105I7R Adenylate cyclase DS731_03435 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) DS731_03440 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DS731_03445 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase DS731_03450 ENOG4107SDU Methyl-accepting chemotaxis DS731_03455 ENOG4105HF0 Membrane DS731_03460 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DS731_03465 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DS731_03470 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DS731_03475 ENOG4105BZU Histidine kinase DS731_03480 ENOG4105BZU Histidine kinase DS731_03500 ENOG4105D3G Pseudouridine synthase DS731_03510 ENOG4108IAB Phoh family DS731_03520 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DS731_03540 ENOG4105DFG type I secretion outer membrane protein DS731_03545 ENOG41087AY ADP-Ribose pyrophosphatase DS731_03550 ENOG4108SX3 cytoplasmic protein DS731_03555 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DS731_03560 ENOG4105IPS esterase DS731_03570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DS731_03575 ENOG410829K Lysine exporter protein (Lyse ygga) DS731_03580 ENOG4107YB6 acetyltransferase, (GNAT) family DS731_03585 ENOG4105BZU Histidine kinase DS731_03595 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 DS731_03615 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DS731_03620 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DS731_03625 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) DS731_03630 ENOG4105D05 Receptor DS731_03635 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DS731_03645 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) DS731_03655 ENOG4105M85 Bola protein DS731_03665 ENOG4105EBR Carboxylesterase DS731_03670 ENOG4108N2Y auxin Efflux DS731_03675 ENOG410841Q phosphoesterase PA-phosphatase related protein DS731_03685 ENOG4105TMB Formate nitrite transporter DS731_03690 ENOG4105D9P serine threonine protein kinase DS731_03695 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) DS731_03710 ENOG4108Z9K Osmotically inducible protein DS731_03715 ENOG4105CHH sulfate transporter DS731_03720 ENOG4107QZF nitrite reductase NADPH large subunit DS731_03725 ENOG4105WZK nitrite reductase NADPH small subunit DS731_03735 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DS731_03740 ENOG4108I0Q anthranilate phosphoribosyltransferase DS731_03755 ENOG4105DG7 nitrate ABC transporter DS731_03760 ENOG4105D7T ABC transporter DS731_03770 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DS731_03775 ENOG4105BZU Histidine kinase DS731_03785 ENOG4108Z33 Thiol disulfide Interchange Protein DS731_03790 ENOG4105E27 serine threonine protein kinase DS731_03815 ENOG4108K8S endonuclease I DS731_03820 ENOG4105CSU acyl-Coa dehydrogenase DS731_03840 ENOG4105CZN Potassium uptake protein DS731_03850 ENOG4105CXK mandelate racemase muconate lactonizing DS731_03855 ENOG4105MP9 class II Aldolase DS731_03865 ENOG410624X efflux transporter, rnd family, mfp subunit DS731_03870 ENOG4105BZS acriflavin resistance protein DS731_03875 ENOG4105FQ6 thiopurine methyltransferase DS731_03880 ENOG4107RUZ Sss sodium solute transporter superfamily DS731_03890 ENOG4106UW1 Major Facilitator superfamily DS731_03895 ENOG4108JQ5 ABC transporter DS731_03900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DS731_03905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DS731_03910 ENOG4105DEF Extracellular solute-binding protein, family 5 DS731_03915 ENOG4105CV8 reductase DS731_03925 ENOG4107S8C mandelate racemase muconate lactonizing DS731_03935 ENOG4105RQF LysR family Transcriptional regulator DS731_03940 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DS731_03945 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DS731_03950 ENOG4105KTH gatB Yqey DS731_03955 ENOG4105VCC 30S ribosomal protein S21 DS731_03960 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DS731_03975 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DS731_03990 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DS731_03995 ENOG4105K59 histidine triad (HIT) protein DS731_04015 ENOG4105EFT decarboxylase DS731_04020 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DS731_04025 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DS731_04030 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase DS731_04035 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DS731_04045 ENOG4108YZT Adenosylcobinamide kinase DS731_04050 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) DS731_04055 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DS731_04060 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) DS731_04065 ENOG4105E0A ABC, transporter DS731_04075 ENOG4105DKK Benzoate DS731_04080 ENOG4105DH7 May be involved in recombination (By similarity) DS731_04085 ENOG4105BZU Histidine kinase DS731_04090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DS731_04095 ENOG4105BZU Histidine kinase DS731_04130 ENOG4109015 Biopolymer transport protein exbD tolR DS731_04135 ENOG41067XB TonB family DS731_04155 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DS731_04160 ENOG4105BZU Histidine kinase DS731_04180 ENOG4107QIJ Aconitate hydratase 2 DS731_04190 ENOG4105CFH Aspartokinase DS731_04195 ENOG41075H3 AraC family transcriptional regulator DS731_04210 ENOG4105C8Q Methyl-accepting chemotaxis DS731_04215 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DS731_04220 ENOG4105NWN ApaG protein DS731_04230 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DS731_04235 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DS731_04240 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) DS731_04245 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) DS731_04250 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_04265 ENOG4105T95 Thiol disulfide interChange protein DS731_04270 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DS731_04280 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) DS731_04285 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DS731_04290 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DS731_04295 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DS731_04300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DS731_04305 ENOG4105DXN mazG family DS731_04315 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DS731_04320 ENOG4108UJD 30S ribosomal protein S9 DS731_04325 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DS731_04330 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DS731_04335 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DS731_04340 ENOG4105EIX cytochrome c1 DS731_04345 ENOG4107MKT Stringent starvation protein a DS731_04350 ENOG4105KB2 stringent starvation protein b DS731_04365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DS731_04370 ENOG4105CJW magnesium transporter DS731_04390 ENOG4108Z12 YiaAB two helix domain-containing protein DS731_04400 ENOG41080Z8 PHOSPHOCARRIER protein DS731_04405 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DS731_04410 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN DS731_04415 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA DS731_04420 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DS731_04425 ENOG4108IUZ ABC transporter DS731_04440 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase DS731_04445 ENOG4105C2X Arabinose 5-phosphate isomerase DS731_04460 ENOG4105DHJ ABC, transporter DS731_04465 ENOG4105CY3 ABC transporter, permease DS731_04470 ENOG4107PE3 Mammalian cell entry related domain protein DS731_04475 ENOG4105E3I toluene tolerance DS731_04485 ENOG4105VFK BolA family DS731_04490 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DS731_04495 ENOG4105JJR Histidine kinase DS731_04500 ENOG4107EXC regulatoR DS731_04515 ENOG4105C0H protease DS731_04520 ENOG4105C0H protease DS731_04530 ENOG4105D6Z AFG1 family ATPase DS731_04535 ENOG4105CDY transcriptional regulatory protein DS731_04595 ENOG4105BZ1 (ABC) transporter DS731_04635 ENOG4105BZU Histidine kinase DS731_04660 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DS731_04665 ENOG4105CV1 Transketolase (EC 2.2.1.1) DS731_04670 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DS731_04675 ENOG4105BZA Phosphoglycerate kinase DS731_04680 ENOG4105WYW fructose-bisphosphate aldolase DS731_04690 ENOG4105C9X ppx gppa phosphatase DS731_04705 ENOG4105C8U phosphate abc transporter DS731_04725 ENOG4105CJ3 phosphate transporter DS731_04730 ENOG4105Q9Y Universal stress protein DS731_04755 ENOG4105D3Q Sugar transferase DS731_04770 ENOG4108QV3 biosynthesis protein DS731_04830 ENOG4105E7A Glutamine amidotransferase DS731_04850 ENOG4108UT2 hemolysin iii DS731_04865 ENOG4105FS7 Transcriptional regulator DS731_04870 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DS731_04890 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit DS731_04900 ENOG4105CHR reductase DS731_04905 ENOG4105E3J oxidoreductase DS731_04920 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DS731_04940 ENOG4105D2S major facilitator superfamily DS731_04955 ENOG4105D82 Glutamate dehydrogenase DS731_04960 ENOG4105NXH GreA GreB family elongation factor DS731_04965 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DS731_04970 ENOG4108JUA Transcriptional regulator DS731_04980 ENOG4108J1Q DS731_04995 ENOG4105CPQ Dehydrogenase DS731_05005 ENOG4105EMU Dehydrogenase DS731_05010 ENOG4105EJC lysr family transcriptional regulator DS731_05015 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DS731_05030 ENOG4105BZU Histidine kinase DS731_05035 ENOG4105BZU Histidine kinase DS731_05050 ENOG4105KCK Peptidoglycan-associated lipoprotein DS731_05065 ENOG4108W5X Transcriptional Regulator, LuxR family DS731_05070 ENOG4105BZU Histidine kinase DS731_05075 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DS731_05080 ENOG4105BZU Histidine kinase DS731_05085 ENOG4108NJZ Sensory box GGDEF EAL domain protein DS731_05095 ENOG4107RH8 nuclease SbcCD subunit D DS731_05100 ENOG4105EYH Exonuclease DS731_05125 ENOG4105QV4 Tryptophan halogenase DS731_05140 ENOG4108PJD permease DS731_05145 ENOG4105W1Y Transcriptional regulator DS731_05160 ENOG4105JJR Histidine kinase DS731_05170 ENOG4105C5H ABC transporter DS731_05185 ENOG4108VKG metal-dependent hydrolase DS731_05195 ENOG41080IJ Diacylglycerol kinase DS731_05210 ENOG4105GR3 Histidine kinase DS731_05230 ENOG4107QNK )-transporter DS731_05260 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DS731_05265 ENOG4105D4T Citrate transporter DS731_05275 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DS731_05285 ENOG4108M0I Transcriptional regulator DS731_05295 ENOG4105BZU Histidine kinase DS731_05325 ENOG4107E2E PKHD-type hydroxylase DS731_05330 ENOG4108ESX Receptor DS731_05410 ENOG4108IJF Heavy metal efflux pump, CzcA DS731_05430 ENOG4105W1Y Transcriptional regulator DS731_05435 ENOG4105C59 p-type ATPase DS731_05470 ENOG4107R7I amino acid DS731_05480 ENOG4105E3B Multicopper oxidase DS731_05505 ENOG4108KB2 LysR family Transcriptional regulator DS731_05510 ENOG4105DTQ mandelate racemase muconate lactonizing DS731_05515 ENOG410626B catechol 1,2-dioxygenase DS731_05540 ENOG4105DKK Benzoate DS731_05555 ENOG4108IV0 ABC, transporter DS731_05560 ENOG4105C0Z ABC transporter DS731_05570 ENOG4105C32 Amino acid ABC transporter (Permease) DS731_05585 ENOG4105F2Z 3-oxoadipate enol-lactonase DS731_05590 ENOG4105CHU acetyl-coa acetyltransferase DS731_05605 ENOG4107HP6 Transcriptional regulator DS731_05610 ENOG4105DTQ mandelate racemase muconate lactonizing DS731_05635 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DS731_05650 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase DS731_05660 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DS731_05670 ENOG4105ERH Fumarylacetoacetate hydrolase DS731_05685 ENOG4105C0R drug resistance transporter emrb qaca subfamily DS731_05695 ENOG4105JSC dimethylmenaquinone methyltransferase DS731_05700 ENOG4108ESX Receptor DS731_05705 ENOG4105CT4 transporter DS731_05760 ENOG41067MG lrgb family DS731_05790 ENOG4105CSA Coproporphyrinogen iii oxidase DS731_05800 ENOG4105C1J atp-dependent rna helicase DS731_05805 ENOG4105C9U ATP-dependent DNA helicase RecQ DS731_05815 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DS731_05830 ENOG4105CPI Metal Dependent Phosphohydrolase DS731_05835 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DS731_05840 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DS731_05845 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DS731_05850 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DS731_05860 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DS731_05865 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DS731_05870 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DS731_05880 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DS731_05885 ENOG4105C8Q Methyl-accepting chemotaxis DS731_05900 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) DS731_05905 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) DS731_05910 ENOG41060IM Heme exporter protein DS731_05915 ENOG4105X3C heme exporter protein DS731_05920 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) DS731_05925 ENOG4105DA4 cytochrome c-type biogenesis protein DS731_05930 ENOG4107QX9 Thiol disulfide interChange protein DS731_05935 ENOG4105KWW Biogenesis protein DS731_05945 ENOG410903C (LipO)protein DS731_05950 ENOG4105CMR udp-glucose 4-epimerase DS731_05960 ENOG4105DUX Transporter DS731_05980 ENOG4107V1M polysaccharide export protein DS731_05990 ENOG4105ESV Glycosyl transferase, family 4 DS731_05995 ENOG4108RYC glycosyltransferase DS731_06005 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DS731_06010 ENOG4105KQC Competence protein DS731_06015 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DS731_06030 ENOG4105EWT decarboxylase family DS731_06035 ENOG4105BZU Histidine kinase DS731_06040 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DS731_06045 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) DS731_06085 ENOG4105QDK Flavodoxin DS731_06090 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) DS731_06095 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) DS731_06100 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DS731_06110 ENOG4105CE9 30S ribosomal protein S2 DS731_06115 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DS731_06120 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DS731_06125 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DS731_06130 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DS731_06135 ENOG4105KNE Phosphatidate cytidylyltransferase DS731_06140 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DS731_06145 ENOG4105DZP Membrane-associated zinc metalloprotease DS731_06160 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DS731_06165 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DS731_06170 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DS731_06175 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DS731_06180 ENOG4105C0B DNA polymerase III (alpha subunit) DS731_06185 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DS731_06190 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DS731_06195 ENOG4105BZU Histidine kinase DS731_06210 ENOG4108Z6B deaminase DS731_06215 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) DS731_06220 ENOG4108ETH Formylglycinamide ribotide synthetase DS731_06260 ENOG4107R88 Chemotaxis protein (CheV) DS731_06265 ENOG4105BZU Histidine kinase DS731_06270 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DS731_06275 ENOG4108ZC9 flagellar basal-body rod protein flgc DS731_06280 ENOG4105W00 Flagellar hook capping protein DS731_06285 ENOG4105BZE flagellar hook protein, FlgE DS731_06290 ENOG4105KTQ flagellar basal-body rod protein DS731_06295 ENOG4105CGA flagellar basal-body rod protein FlgG DS731_06300 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DS731_06305 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DS731_06310 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DS731_06315 ENOG4105E1Q flagellar hook-associated protein DS731_06330 ENOG4105I03 Flagellin DS731_06335 ENOG4105I03 Flagellin DS731_06340 ENOG4105I03 Flagellin DS731_06345 ENOG41063QE flagellar protein FlaG DS731_06355 ENOG4105MQ3 flagellar protein FliS DS731_06365 ENOG4105C5E polysaccharide biosynthesis protein DS731_06370 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DS731_06375 ENOG4105F0R Cytidylyltransferase DS731_06385 ENOG4105D2T synthase DS731_06405 ENOG4105CHR reductase DS731_06430 ENOG4107YYJ Glycosyl transferase, family 2 DS731_06455 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DS731_06460 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DS731_06465 ENOG4105C0K Gdp-mannose 4,6-dehydratase DS731_06470 ENOG4105DVA methyltransferase DS731_06475 ENOG4107R0V Pyruvate dehydrogenase DS731_06480 ENOG4105CPP Dehydrogenase, E1 component DS731_06490 ENOG4105C7K acetolactate synthase DS731_06505 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DS731_06515 ENOG4105I03 Flagellin DS731_06520 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_06525 ENOG4105BZU Histidine kinase DS731_06530 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_06535 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DS731_06540 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DS731_06545 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DS731_06555 ENOG4108JIR Flagellum-specific ATP synthase DS731_06575 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DS731_06580 ENOG4105DD5 Flagellar motor switch protein DS731_06585 ENOG4105VTB flagellar biosynthesis protein fliO DS731_06590 ENOG4105CN7 Flagellar biosynthetic protein FliP DS731_06595 ENOG4105VS8 Flagellar biosynthetic protein fliq DS731_06600 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DS731_06605 ENOG4105D00 flagellar biosynthetic protein flhB DS731_06610 ENOG4105BZU Histidine kinase DS731_06615 ENOG4105D7B Flagellar biosynthesis protein flha DS731_06620 ENOG4105FZW flagellar biosynthesis regulator FlhF DS731_06630 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DS731_06635 ENOG4108VYJ response regulator receiver protein DS731_06640 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) DS731_06645 ENOG4105CBS Chea signal transduction histidine kinase DS731_06650 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DS731_06655 ENOG4107QJE Chromosome Partitioning Protein DS731_06665 ENOG4105YFD chemotaxis, protein DS731_06675 ENOG4108XM1 transcriptional regulator AsnC family DS731_06685 ENOG4105CVG Homoserine O-transsuccinylase DS731_06690 ENOG4105C3R Methionine synthase DS731_06695 ENOG4105C3R Methionine synthase DS731_06715 ENOG4105DZ2 Transcriptional regulator DS731_06725 ENOG4107B2H carbonic anhydrase DS731_06735 ENOG4107B2H carbonic anhydrase DS731_06740 ENOG4105CHH sulfate transporter DS731_06745 ENOG4105D05 Receptor DS731_06755 ENOG4105C9K Endothelin-converting enzyme 1 DS731_06765 ENOG4105Y3E Modulates RecA activity (By similarity) DS731_06770 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DS731_06775 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DS731_06795 ENOG4105XJC Two component transcriptional regulator (Winged helix family DS731_06800 ENOG4105DHQ Histidine kinase DS731_06850 ENOG4107QSA Oxaloacetate decarboxylase DS731_06855 ENOG4105D9Q decarboxylase (Beta subunit) DS731_06860 ENOG4108JQ2 peptide transport system atp-binding protein DS731_06865 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein DS731_06870 ENOG4108EU3 peptide transport system, permease DS731_06875 ENOG4108I5W peptide transport system, permease protein DS731_06880 ENOG4105DEF Extracellular solute-binding protein, family 5 DS731_06885 ENOG4105E51 psp operon transcriptional activator DS731_06890 ENOG41087YS Phage shock protein A DS731_06895 ENOG4105YYT phage shock protein B DS731_06905 ENOG4105MIR Phenylalanine 4-monooxygenase DS731_06915 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DS731_06920 ENOG4105F1J Homogentisate 1,2-dioxygenase DS731_06930 ENOG4108RXX maleylacetoacetate isomerase DS731_06935 ENOG4108XM1 transcriptional regulator AsnC family DS731_06940 ENOG4107RDP Dehydrogenase DS731_06955 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) DS731_06990 ENOG4109015 Biopolymer transport protein exbD tolR DS731_06995 ENOG410822N TonB family DS731_07005 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) DS731_07055 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DS731_07060 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DS731_07065 ENOG4105C75 arginyL-tRNA synthetase DS731_07070 ENOG410642W LysR family Transcriptional regulator DS731_07075 ENOG4105CHR reductase DS731_07085 ENOG4105CRK lysyL-tRNA synthetase DS731_07090 ENOG4105S64 Formate nitrite transporter DS731_07095 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DS731_07100 ENOG4108W1A pseudouridine synthase DS731_07115 ENOG4105D9M gamma-glutamylcysteine synthetase DS731_07130 ENOG4108DG9 Smr protein MutS2 DS731_07135 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) DS731_07140 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DS731_07155 ENOG4105ED1 spovr family DS731_07160 ENOG4106AKX UPF0229 protein DS731_07165 ENOG4105CYN Serine protein kinase DS731_07170 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DS731_07175 ENOG4105M2J Glutaredoxin DS731_07180 ENOG4105D05 Receptor DS731_07200 ENOG4105W53 bacterioferritin-associated ferredoxin DS731_07205 ENOG4105D3R alkyl hydroperoxide reductase DS731_07210 ENOG4107QNK )-transporter DS731_07215 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) DS731_07220 ENOG4105EIY sodium-type flagellar protein motY DS731_07225 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DS731_07240 ENOG4105CSM endonuclease III DS731_07245 ENOG4105DZB Electron transport complex DS731_07250 ENOG4108UQQ Electron transport complex DS731_07255 ENOG4105D6A Electron transport complex DS731_07265 ENOG4108R3D Electron transport complex DS731_07270 ENOG4105DGN Electron transport complex DS731_07290 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DS731_07430 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_07455 ENOG4107XMK single-stranded DNA-binding protein DS731_07550 ENOG4107Y5K Resolvase DS731_07565 ENOG4107QJQ Mate efflux family protein DS731_07570 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DS731_07580 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DS731_07585 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DS731_07595 ENOG4105CAQ asparagine synthetase DS731_07615 ENOG4108IUW ABC transporter DS731_07620 ENOG4108SDH ABC, transporter DS731_07630 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) DS731_07635 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase DS731_07640 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DS731_07645 ENOG4105C11 sulfate adenylyltransferase), subunit 2 DS731_07650 ENOG4105CK7 Sodium proline symporter DS731_07660 ENOG4105EMN RNA polymerase sigma factor DS731_07695 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DS731_07700 ENOG4105CHU acetyl-coa acetyltransferase DS731_07705 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DS731_07715 ENOG4105BZU Histidine kinase DS731_07735 ENOG4108JU6 CBS domain protein DS731_07740 ENOG4106KVJ cytochrome C assembly protein DS731_07745 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DS731_07780 ENOG4105BZ1 (ABC) transporter DS731_07785 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_07795 ENOG4105EQD regulatoR DS731_07800 ENOG4105K5M 30s ribosomal protein S16 DS731_07805 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DS731_07810 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DS731_07815 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DS731_07825 ENOG4105BZU Histidine kinase DS731_07845 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DS731_07870 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) DS731_07885 ENOG4108VYJ response regulator receiver protein DS731_07890 ENOG4108ZJT translation initiation factor, Sui1 DS731_07900 ENOG4105BZU Histidine kinase DS731_07910 ENOG4105BZU Histidine kinase DS731_07920 ENOG4107WP9 Histidine kinase DS731_07930 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_07940 ENOG4105C9M aspartyl-trna synthetase DS731_07945 ENOG4108TIT dATP pyrophosphohydrolase DS731_07950 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DS731_07955 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DS731_07960 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DS731_07965 ENOG4107YD3 Thioesterase DS731_07970 ENOG4105E02 MotA TolQ exbB proton channel DS731_07975 ENOG4105M8F Biopolymer transport protein exbD tolR DS731_07985 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DS731_07990 ENOG4105KCK Peptidoglycan-associated lipoprotein DS731_07995 ENOG4105UFD tol-pal system protein YbgF DS731_08010 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DS731_08025 ENOG4105UTS cellulose synthase operon protein YhjQ DS731_08040 ENOG4105EJG cellulose synthase DS731_08045 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) DS731_08050 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DS731_08055 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DS731_08080 ENOG4105BZU Histidine kinase DS731_08090 ENOG4105DY2 Paraquat-inducible protein b DS731_08095 ENOG4105F1S paraquat-inducible protein a DS731_08100 ENOG4105C5S asparaginyl-tRNA synthetase DS731_08115 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DS731_08145 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DS731_08150 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DS731_08155 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DS731_08160 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DS731_08165 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) DS731_08175 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase DS731_08180 ENOG4107R37 Glutamate dehydrogenase DS731_08185 ENOG4105CHR reductase DS731_08190 ENOG4105KJF protein tyrosine phosphatase DS731_08195 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase DS731_08210 ENOG4105DDI hemolysin-type calcium-binding region DS731_08220 ENOG4108JJ7 ABC transporter DS731_08225 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DS731_08260 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DS731_08300 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) DS731_08305 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DS731_08310 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DS731_08320 ENOG4108I0Y (ABC) transporter DS731_08325 ENOG4105CV6 ABC transporter, permease DS731_08335 ENOG410624X efflux transporter, rnd family, mfp subunit DS731_08360 ENOG4108JCI Transcriptional regulator DS731_08370 ENOG4105ECP epimerase DS731_08375 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase DS731_08380 ENOG4105DSF transport protein DS731_08385 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit DS731_08390 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DS731_08400 ENOG4107QIJ Aconitate hydratase 2 DS731_08410 ENOG4105XJC Two component transcriptional regulator (Winged helix family DS731_08425 ENOG4105K9H YciI-like protein DS731_08435 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DS731_08440 ENOG4105DK0 Indole-3-glycerol phosphate synthase DS731_08445 ENOG4108I0Q anthranilate phosphoribosyltransferase DS731_08450 ENOG4108EFP Anthranilate synthase component II DS731_08455 ENOG4105CRQ synthase (Component I) DS731_08460 ENOG4105DB7 PHP domain protein DS731_08465 ENOG4107RTD sua5 ycio yrdc ywlc family protein DS731_08475 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DS731_08480 ENOG4105FE9 pseudouridine synthase DS731_08490 ENOG4105CV8 reductase DS731_08495 ENOG4106BRA Membrane DS731_08510 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DS731_08515 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DS731_08520 ENOG4107QNK )-transporter DS731_08540 ENOG4105E2R ROK family DS731_08545 ENOG41072TH Protein of unknown function (DUF1479) DS731_08570 ENOG4105JAB phenazine biosynthesis protein, phzf family DS731_08600 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DS731_08615 ENOG4105DWV Homoserine O-trans-acetylase DS731_08620 ENOG4105CY2 Citrate transporter DS731_08635 ENOG4105BZU Histidine kinase DS731_08640 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DS731_08645 ENOG4105CFG Acts as a chaperone (By similarity) DS731_08650 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DS731_08655 ENOG4105DQ6 Transposase DS731_08660 ENOG4105IYK transposase DS731_08665 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DS731_08670 ENOG4105BZU Histidine kinase DS731_08680 ENOG4105CX8 fg-gap repeat protein DS731_08695 ENOG4108MRH transcriptional regulatory protein DS731_08700 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DS731_08725 ENOG4105EBR Carboxylesterase DS731_08750 ENOG4105BZU Histidine kinase DS731_08755 ENOG4105DND Transcriptional regulator DS731_08760 ENOG4105JSC dimethylmenaquinone methyltransferase DS731_08770 ENOG4105KHM amidohydrolase 2 DS731_08790 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation DS731_08820 ENOG4105BZU Histidine kinase DS731_08845 ENOG4106322 response regulator DS731_08850 ENOG4105EQR Transposase IS116 IS110 IS902 DS731_08860 ENOG4105K3G Periplasmic Protein DS731_08870 ENOG410903C (LipO)protein DS731_08895 ENOG4105DK2 UPF0207 protein DS731_08930 ENOG4105BZU Histidine kinase DS731_08950 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_08955 ENOG4105BZU Histidine kinase DS731_08970 ENOG41080HT Transcriptional regulator, arsr family DS731_08985 ENOG4105CVI Transcriptional regulator DS731_09015 ENOG4105BZU Histidine kinase DS731_09030 ENOG4108IQE Amp-dependent synthetase and ligase DS731_09045 ENOG4105DSY exodeoxyribonuclease V, gamma DS731_09050 ENOG4107QKA exodeoxyribonuclease V beta DS731_09055 ENOG4107QYX exodeoxyribonuclease v alpha DS731_09075 ENOG4105D06 uba thif-type nad fad binding protein DS731_09080 ENOG4108RIR Molybdenum cofactor biosynthesis protein DS731_09085 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DS731_09090 ENOG4105M00 molybdopterin converting factor, subunit 1 DS731_09095 ENOG4108ZAF Molybdopterin DS731_09100 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DS731_09105 ENOG4105E0C molybdate abc transporter DS731_09110 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DS731_09115 ENOG4105D4P Coproporphyrinogen iii oxidase DS731_09140 ENOG4105KZX Pterin carbinolamine dehydratase DS731_09155 ENOG4105BZU Histidine kinase DS731_09160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DS731_09165 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DS731_09170 ENOG4105CHV Transcription elongation factor NusA DS731_09175 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DS731_09180 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DS731_09185 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DS731_09190 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DS731_09200 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DS731_09210 ENOG4105BZU Histidine kinase DS731_09215 ENOG4105BZU Histidine kinase DS731_09225 ENOG4105D3R alkyl hydroperoxide reductase DS731_09240 ENOG4108IG5 Transcriptional regulator DS731_09265 ENOG4105CCT upf0313 protein DS731_09280 ENOG4105CI2 imidazolone-5-propionate hydrolase DS731_09295 ENOG4105FE9 pseudouridine synthase DS731_09320 ENOG4107ZVI PhiRv2 prophage protein DS731_09350 ENOG4105DFP Integrase DS731_09380 ENOG4105K6V RNA polymerase DS731_09385 ENOG4105VYA Uncharacterized conserved protein (DUF2132) DS731_09390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DS731_09395 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DS731_09400 ENOG4108Z1B Cyclase dehydrase DS731_09405 ENOG4105VDB UPF0125 protein DS731_09415 ENOG4105C94 Transporter DS731_09420 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_09425 ENOG4107RDJ Sulfotransferase DS731_09430 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DS731_09435 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DS731_09455 ENOG4105EZE Cupin 4 family protein DS731_09465 ENOG4107QTF adenylosuccinate lyase DS731_09470 ENOG41075W9 High frequency lysogenization protein HflD homolog DS731_09475 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DS731_09480 ENOG4108R99 pseudouridine synthase DS731_09485 ENOG4105E9K Isocitrate dehydrogenase DS731_09490 ENOG4105VEQ Cold shock protein DS731_09495 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DS731_09500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DS731_09505 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DS731_09510 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate DS731_09515 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) DS731_09520 ENOG4105C3M thioredoxin reductase DS731_09530 ENOG4105GPY SprT protein DS731_09535 ENOG4105D07 Signal peptide peptidase, SppA DS731_09540 ENOG41069NU Nitroreductase DS731_09545 ENOG4105CA9 Pyruvate kinase DS731_09550 ENOG4106KNT transcriptional regulator DS731_09555 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DS731_09565 ENOG4105C01 Dihydroxy-acid dehydratase DS731_09570 ENOG4105CHC glucokinase (EC 2.7.1.2) DS731_09575 ENOG4108UHU Aldolase DS731_09590 ENOG4105DSB aldose 1-epimerase DS731_09600 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) DS731_09605 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DS731_09615 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DS731_09620 ENOG4105E0X reductase DS731_09640 ENOG4105BZG amino acid carrier protein DS731_09650 ENOG4105VUT cytoplasmic protein DS731_09670 ENOG4105HDK L-asparaginase DS731_09685 ENOG4105BZU Histidine kinase DS731_09690 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DS731_09695 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DS731_09700 ENOG4108Z43 UPF0250 protein DS731_09705 ENOG4105DZ1 carboxypeptidase DS731_09710 ENOG4105K6T rare lipoprotein A DS731_09715 ENOG4105CNI cell division protein FtsW DS731_09720 ENOG4105CJN penicillin-binding protein DS731_09725 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DS731_09730 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) DS731_09740 ENOG4108U2H Rare lipoprotein B DS731_09745 ENOG4105C8T Leucyl-tRNA synthetase DS731_09755 ENOG4105DAN ATP-dependent protease DS731_09770 ENOG4105HBR Rna-binding protein DS731_09775 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DS731_09780 ENOG4105EEI dihydropteroate synthase DS731_09785 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DS731_09790 ENOG4105CP7 Triose-phosphate isomerase DS731_09845 ENOG4105EQR Transposase IS116 IS110 IS902 DS731_09855 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) DS731_09890 ENOG4105C2M dna polymerase I DS731_09900 ENOG4105C7H Helicase, RecD TraA family DS731_09995 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DS731_10105 ENOG41090BQ Glutaredoxin DS731_10190 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DS731_10230 ENOG4105EXU Membrane DS731_10235 ENOG4107TE5 Lipid kinase DS731_10255 ENOG4105CK7 Sodium proline symporter DS731_10265 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DS731_10280 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DS731_10305 ENOG4105EXN Sulfate transport protein CysZ DS731_10310 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DS731_10315 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) DS731_10320 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DS731_10330 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 DS731_10335 ENOG4105BZ1 (ABC) transporter DS731_10340 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DS731_10345 ENOG4105W49 UPF0434 protein DS731_10350 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) DS731_10355 ENOG4108RU0 short-chain dehydrogenase reductase DS731_10365 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) DS731_10380 ENOG4105CUZ uba thif-type nad fad binding protein DS731_10385 ENOG4105CHF Glutathione S-transferase DS731_10390 ENOG4105EUB pirin domain protein DS731_10395 ENOG4105CJT Mannose-1-phosphate guanylyltransferase DS731_10410 ENOG4105BZN citrate synthase DS731_10415 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit DS731_10420 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein DS731_10425 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) DS731_10430 ENOG4105E33 succinate dehydrogenase DS731_10435 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DS731_10440 ENOG4105C7S Dehydrogenase DS731_10445 ENOG4105CMV Succinyl-CoA synthetase subunit beta DS731_10450 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DS731_10455 ENOG4105C8Q Methyl-accepting chemotaxis DS731_10500 ENOG4108IUK alpha amylase, catalytic DS731_10520 ENOG4105CX6 glutaminyL-tRNA synthetase DS731_10530 ENOG4105UBK short-chain dehydrogenase reductase DS731_10535 ENOG4108M0H Extracellular lipase DS731_10555 ENOG4105ERU peptidase DS731_10565 ENOG4107QNR UPF0135 protein DS731_10570 ENOG4106371 Methyltransferase DS731_10575 ENOG4105C5I Dehydrogenase DS731_10580 ENOG4108V06 Glutathione peroxidase DS731_10585 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DS731_10595 ENOG4105C26 Dehydrogenase DS731_10600 ENOG4105C1G acyl-Coa dehydrogenase DS731_10605 ENOG4108UKI Enoyl-CoA hydratase DS731_10610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DS731_10615 ENOG4105DHI Methyltransferase DS731_10620 ENOG4105E68 Sulfatase DS731_10625 ENOG4105PAN UPF0352 protein DS731_10630 ENOG4106V8H Nucleoid-associated protein DS731_10660 ENOG4108HRK Histidine kinase DS731_10665 ENOG4105DY9 regulatoR DS731_10670 ENOG4105CTQ phosphohexokinase DS731_10680 ENOG4105QYV Membrane DS731_10685 ENOG4105BZU Histidine kinase DS731_10695 ENOG4105C72 UPF0176 protein DS731_10705 ENOG4105C1J atp-dependent rna helicase DS731_10715 ENOG4105D6N CoA-transferase, subunit a DS731_10720 ENOG4105F04 LysR family Transcriptional regulator DS731_10740 ENOG4107R11 Transcriptional regulator DS731_10745 ENOG4105EJQ L-serine dehydratase DS731_10765 ENOG4105CGY Dna recombination protein DS731_10855 ENOG4105K3M )-transporter DS731_10870 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DS731_10885 ENOG4105CPP Dehydrogenase, E1 component DS731_10895 ENOG4105D6S protein involved in catabolism of external DNA DS731_10905 ENOG4105C29 acyl-CoA thioesterase DS731_10910 ENOG4105C5R Aminotransferase DS731_10925 ENOG4108JIC nucleoside recognition domain protein DS731_10935 ENOG4108ZGC gaf domain protein DS731_10945 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) DS731_10950 ENOG4105CN1 protease DS731_10955 ENOG4105C8J )-transporter DS731_10960 ENOG4105DFD Na H antiporter DS731_10965 ENOG4105CD8 aminopeptidase N DS731_10980 ENOG4105D25 secreted protein DS731_10995 ENOG4105C7I Dehydrogenase DS731_11000 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) DS731_11005 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DS731_11015 ENOG4105C5H ABC transporter DS731_11025 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) DS731_11030 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) DS731_11040 ENOG4105CVP deoxyribo-dipyrimidine photolyase DS731_11045 ENOG4105CVP deoxyribo-dipyrimidine photolyase DS731_11050 ENOG4105CVP deoxyribo-dipyrimidine photolyase DS731_11055 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein DS731_11090 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_11115 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DS731_11130 ENOG4108KPZ tonB-dependent Receptor DS731_11140 ENOG41081QV Universal stress protein DS731_11145 ENOG4105CBC glutamate synthase DS731_11150 ENOG4105CKD glutathione-regulated potassium-efflux system protein DS731_11155 ENOG4108UQY Iron-storage protein DS731_11170 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i DS731_11185 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) DS731_11195 ENOG4105C59 p-type ATPase DS731_11210 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DS731_11215 ENOG4105Q9Y Universal stress protein DS731_11220 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) DS731_11225 ENOG4105D78 K07001 NTE family protein DS731_11250 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DS731_11255 ENOG4105KHC sulfurtransferase DS731_11280 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DS731_11285 ENOG4105WH1 Two component transcriptional regulator luxr family DS731_11290 ENOG4105C2I pirin domain protein DS731_11295 ENOG4105C87 Aminotransferase class I and II DS731_11315 ENOG4108MN8 Membrane DS731_11325 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) DS731_11335 ENOG4108Z0T Part of a sulfur-relay system (By similarity) DS731_11340 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DS731_11345 ENOG4105WMR Protein CrcB homolog DS731_11350 ENOG4105D1H recombination factor protein RarA DS731_11355 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) DS731_11360 ENOG4105CNU cell division protein FtsK DS731_11365 ENOG4105EW9 transcriptional regulator AsnC family DS731_11370 ENOG4105DCF alanine dehydrogenase DS731_11375 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DS731_11380 ENOG4105CFV Tetratricopeptide repeat protein DS731_11385 ENOG4105Q4A inner membrane protein yciS DS731_11395 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DS731_11400 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DS731_11405 ENOG4105CAT Cytidine monophosphate kinase DS731_11410 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DS731_11420 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DS731_11430 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DS731_11435 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DS731_11440 ENOG4105XPH Ferredoxin DS731_11450 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DS731_11465 ENOG4105C8V SAICAR synthetase DS731_11470 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DS731_11475 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DS731_11485 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DS731_11495 ENOG4105ERG peptidase m48, ste24p DS731_11500 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DS731_11505 ENOG4105K89 arsenate reductase DS731_11510 ENOG4105CS1 NAD(P)H quinone oxidoreductase DS731_11520 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) DS731_11530 ENOG4105CXB phosphoribosylaminoimidazole synthetase DS731_11535 ENOG4108V3E phosphoribosylglycinamide formyltransferase DS731_11545 ENOG4107QPN acyl-Coa dehydrogenase DS731_11555 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) DS731_11560 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) DS731_11575 ENOG4105C3Q Glycosyl transferase, family 2 DS731_11580 ENOG4107QW3 Sucrose phosphorylase DS731_11585 ENOG4105CVM Molybdenum cofactor synthesis domain protein DS731_11590 ENOG4107QI1 Mate efflux family protein DS731_11605 ENOG4105XRQ Xanthine dehydrogenase accessory factor DS731_11610 ENOG4105C6T cysteine synthase DS731_11620 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DS731_11625 ENOG41060WC Enoyl-CoA hydratase DS731_11660 ENOG4108IQK o-acetylhomoserine DS731_11670 ENOG4105CGF Aromatic amino acid aminotransferase DS731_11690 ENOG4105CW7 secretion protein, HlyD family DS731_11700 ENOG4105C10 Electron transfer flavoprotein DS731_11705 ENOG4105BZJ Electron transfer flavoprotein DS731_11710 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase DS731_11720 ENOG4105EV9 Alpha Beta Hydrolase DS731_11730 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) DS731_11735 ENOG4105C8Q Methyl-accepting chemotaxis DS731_11740 ENOG41090R7 Ferric uptake DS731_11755 ENOG4105P4J Allophanate hydrolase, subunit 1 DS731_11760 ENOG4105E7W lamb ycsf family protein DS731_11765 ENOG4105QNR S1 RNA binding domain protein DS731_11770 ENOG4108UKZ OsmC family DS731_11780 ENOG4105ENT Efflux transporter rnd family, mfp subunit DS731_11800 ENOG4105CHM Aminotransferase DS731_11805 ENOG4105DK2 UPF0207 protein DS731_11810 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein DS731_11820 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) DS731_11825 ENOG4105M4H endoribonuclease L-psp DS731_11830 ENOG4107TJ9 Cytochrome DS731_11835 ENOG4105MWK D-amino acid dehydrogenase, small subunit DS731_11850 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DS731_11860 ENOG4105F8V Hydrolase, tatD family DS731_11865 ENOG4107QRG dna polymerase iii DS731_11870 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DS731_11875 ENOG4105HHA aminodeoxychorismate lyase DS731_11880 ENOG4105YAZ 4-amino-4-deoxychorismate lyase DS731_11885 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DS731_11890 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DS731_11895 ENOG4105CHR reductase DS731_11900 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DS731_11905 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DS731_11910 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DS731_11915 ENOG4105VGS 50s ribosomal protein l32 DS731_11920 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein DS731_11930 ENOG4107XGZ Hydrolase DS731_11935 ENOG4105EI2 Pseudouridine synthase DS731_11945 ENOG4105C03 ribonuclease DS731_11955 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme DS731_11960 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DS731_11965 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) DS731_11970 ENOG4105TNG K13735 adhesin invasin DS731_11975 ENOG4105CK2 sodium dicarboxylate symporter DS731_11980 ENOG4105D60 lipoprotein releasing system transmembrane protein DS731_11985 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DS731_12020 ENOG4108JDX DNA polymerase iii, epsilon subunit DS731_12025 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DS731_12030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DS731_12040 ENOG4105Y49 secretion protein, HlyD family DS731_12045 ENOG4108NVR Methyl-accepting chemotaxis DS731_12065 ENOG4107RRD Dehydrogenase DS731_12070 ENOG4105DR4 Methyltransferase DS731_12080 ENOG4105CQ7 ATP-dependent helicase DS731_12085 ENOG4105IYK transposase DS731_12090 ENOG4105DQ6 Transposase DS731_12100 ENOG4105BZU Histidine kinase DS731_12120 ENOG4105D44 asparaginase DS731_12125 ENOG4105CJB Exodeoxyribonuclease I DS731_12135 ENOG4105BZU Histidine kinase DS731_12145 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin DS731_12150 ENOG4105CHU acetyl-coa acetyltransferase DS731_12155 ENOG4108Z6Z Transcriptional regulator DS731_12160 ENOG4105C1G acyl-Coa dehydrogenase DS731_12165 ENOG4107QX3 carboxylase DS731_12170 ENOG4108UKI Enoyl-CoA hydratase DS731_12180 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DS731_12195 ENOG4105DU0 nucleoside hydrolase DS731_12200 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DS731_12215 ENOG4108HU6 Metal dependent phosphohydrolase DS731_12230 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) DS731_12250 ENOG4105BZU Histidine kinase DS731_12255 ENOG4105BZU Histidine kinase DS731_12265 ENOG4105CGK Exodeoxyribonuclease III DS731_12280 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DS731_12285 ENOG4105D60 lipoprotein releasing system transmembrane protein DS731_12295 ENOG4108JA2 transcriptioN-repair coupling factor DS731_12305 ENOG4105C8P )-transporter DS731_12310 ENOG4108Z66 YbaK ebsC protein DS731_12320 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DS731_12325 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DS731_12330 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DS731_12335 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DS731_12340 ENOG41082NX 50s ribosomal protein l35 DS731_12350 ENOG4105C22 threonyL-tRNA synthetase DS731_12355 ENOG4105FGM Fructosamine kinase DS731_12370 ENOG4108VWS Yaeq family DS731_12390 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DS731_12395 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DS731_12400 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DS731_12405 ENOG4105HF0 Membrane DS731_12410 ENOG4105C5R Aminotransferase DS731_12425 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DS731_12430 ENOG4105C2W permease DS731_12445 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DS731_12450 ENOG4105C7N Xanthine uracil vitamin C permease DS731_12455 ENOG4105KME endoribonuclease L-psp DS731_12460 ENOG4105BZU Histidine kinase DS731_12470 ENOG4108R86 Transcriptional regulator DS731_12480 ENOG4105C7W Xanthine dehydrogenase DS731_12500 ENOG4107QUY Guanine deaminase DS731_12520 ENOG4107SET aldo keto reductase DS731_12525 ENOG4105EQ2 LysR family Transcriptional regulator DS731_12540 ENOG4105C4C beta-galactosidase DS731_12555 ENOG4108CIP transcriptional regulator DS731_12560 ENOG4108K2F hydrolase Family 5 DS731_12565 ENOG4105C1P efflux transporter, rnd family, mfp subunit DS731_12615 ENOG4106CVF DNA replication protein DS731_12620 ENOG4106YSC DS731_12670 ENOG4108ZT1 Transcriptional regulator DS731_12690 ENOG4108RYR transcriptional regulator AsnC family DS731_12695 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase DS731_12700 ENOG4105BZU Histidine kinase DS731_12705 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DS731_12710 ENOG4105EN6 Membrane DS731_12720 ENOG4105EIG urea carboxylase-associated protein 1 DS731_12750 ENOG4105C94 Transporter DS731_12780 ENOG4105CH2 amidohydrolase DS731_12795 ENOG4105D64 Mechanosensitive ion channel DS731_12800 ENOG4105F27 Major Facilitator DS731_12810 ENOG4105CI2 imidazolone-5-propionate hydrolase DS731_12835 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_12865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DS731_12880 ENOG4105CJP fad dependent oxidoreductase DS731_12895 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DS731_12900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DS731_12905 ENOG4105C26 Dehydrogenase DS731_12910 ENOG4108V1U phospholipid-binding protein DS731_12960 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DS731_12970 ENOG4105D05 Receptor DS731_12985 ENOG4105D05 Receptor DS731_12995 ENOG4105EMN RNA polymerase sigma factor DS731_13000 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DS731_13005 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DS731_13010 ENOG4105CBS Chea signal transduction histidine kinase DS731_13025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DS731_13030 ENOG4108RH0 Crea protein DS731_13045 ENOG4105KUZ arsenate reductase DS731_13050 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DS731_13065 ENOG4105K8R UPF0145 protein DS731_13075 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) DS731_13080 ENOG4105BZU Histidine kinase DS731_13090 ENOG4105EGI Transcriptional regulator DS731_13100 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) DS731_13105 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 DS731_13110 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) DS731_13115 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DS731_13125 ENOG4105F8C transglutaminase domain-containing protein DS731_13130 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DS731_13135 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) DS731_13150 ENOG4105ETT transcriptional Regulator, LysR family DS731_13160 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DS731_13170 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DS731_13175 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DS731_13180 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DS731_13185 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DS731_13190 ENOG4108986 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) DS731_13195 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DS731_13205 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DS731_13220 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DS731_13225 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DS731_13230 ENOG4105C3G gtp-binding protein DS731_13235 ENOG4105CRW Short chain fatty acid transporter DS731_13260 ENOG4105BZG amino acid carrier protein DS731_13270 ENOG4108IND Tetr family transcriptional regulator DS731_13280 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DS731_13285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DS731_13290 ENOG4105C9A Phoh family DS731_13295 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DS731_13300 ENOG4108JU5 Magnesium and cobalt efflux protein DS731_13305 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DS731_13310 ENOG4105CI2 imidazolone-5-propionate hydrolase DS731_13330 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DS731_13335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DS731_13340 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DS731_13345 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DS731_13355 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DS731_13360 ENOG4105BZU Histidine kinase DS731_13365 ENOG41085AF Cytochrome DS731_13370 ENOG410829K Lysine exporter protein (Lyse ygga) DS731_13415 ENOG4105C8P )-transporter DS731_13420 ENOG4105DHP deoxycytidine triphosphate deaminase DS731_13425 ENOG4105D1F ATP-binding protein DS731_13430 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DS731_13435 ENOG4107RF4 Phosphodiesterase DS731_13440 ENOG4105D1A Methyltransferase DS731_13445 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DS731_13450 ENOG4105E9H Lytic Murein transglycosylase DS731_13460 ENOG4105C8N cysteinyl-tRNA synthetase DS731_13465 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DS731_13470 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) DS731_13480 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DS731_13500 ENOG4105G6Z alkaline phosphatase DS731_13505 ENOG4105G6Z alkaline phosphatase DS731_13515 ENOG4105PV3 Inner membrane protein yqiJ DS731_13520 ENOG4107S78 Band 7 protein DS731_13525 ENOG4105ENE Histidine kinase DS731_13535 ENOG4105DZG Dehydrogenase DS731_13545 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase DS731_13550 ENOG4105CVJ phosphoglycerate mutase DS731_13565 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DS731_13570 ENOG4105E96 Colicin v production protein DS731_13575 ENOG4108S3P Sporulation domain protein DS731_13580 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DS731_13585 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DS731_13590 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DS731_13605 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) DS731_13615 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) DS731_13645 ENOG4108BPE -transporting atpase DS731_13665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DS731_13685 ENOG4105D8T Acyltransferase DS731_13690 ENOG4105U5Y Transcriptional regulator DS731_13695 ENOG4108UH6 UPF0754 membrane protein DS731_13730 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) DS731_13735 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DS731_13740 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) DS731_13745 ENOG4108428 Inherit from COG: -acetyltransferase DS731_13750 ENOG4108ZZ3 UPF0260 protein DS731_13755 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DS731_13765 ENOG4105VNG YcgL domain-containing protein DS731_13770 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) DS731_13775 ENOG4105CEY Amp-dependent synthetase and ligase DS731_13780 ENOG410832A alpha/beta hydrolase fold DS731_13795 ENOG41072GX Peptidase M22 Glycoprotease DS731_13800 ENOG4105DVT helicase DS731_13820 ENOG4105C8Q Methyl-accepting chemotaxis DS731_13835 ENOG41082YX Transcriptional regulator, arsr family DS731_13845 ENOG4105D6J arsenicaL-resistance protein DS731_13860 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DS731_13865 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DS731_13870 ENOG4105CIH Imidazole acetol-phosphate transaminase DS731_13875 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DS731_13880 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DS731_13885 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DS731_13890 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DS731_13895 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DS731_13905 ENOG4105C3F Signal peptidase i DS731_13910 ENOG4108ZNX Heat shock protein DS731_13920 ENOG4105JQN Transcriptional regulator DS731_13925 ENOG4105ECR NmrA family DS731_13940 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DS731_13945 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DS731_13950 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DS731_13965 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DS731_13970 ENOG4107QMP dna polymerase iii subunits gamma and tau DS731_13975 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DS731_13985 ENOG4105E18 UPF0276 protein DS731_13995 ENOG4108W2P Methyl-accepting chemotaxis DS731_14030 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DS731_14050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DS731_14055 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DS731_14060 ENOG4105C34 Pseudouridine synthase DS731_14065 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DS731_14070 ENOG4108NIX Factor ChrR DS731_14075 ENOG4105K6V RNA polymerase DS731_14090 ENOG4105EMU Dehydrogenase DS731_14105 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DS731_14110 ENOG4106VK6 Flagellar motor protein DS731_14115 ENOG4105E14 MotA TolQ exbB proton channel DS731_14120 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DS731_14125 ENOG4105CTB Polyprenyl synthetase DS731_14130 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DS731_14135 ENOG4108ZAI phosphatidylglycerophosphatase a DS731_14140 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DS731_14145 ENOG4107YIM Involved in the transcription termination process (By similarity) DS731_14150 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DS731_14165 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DS731_14170 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DS731_14175 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DS731_14180 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DS731_14185 ENOG4105C5H ABC transporter DS731_14195 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DS731_14205 ENOG4105EAC phosphoserine phosphatase DS731_14215 ENOG4105EYA deoxyribonuclease DS731_14220 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) DS731_14225 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DS731_14230 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DS731_14235 ENOG4105C3F Signal peptidase i DS731_14240 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DS731_14260 ENOG4105EMN RNA polymerase sigma factor DS731_14265 ENOG4108IYU L-aspartate oxidase DS731_14280 ENOG4105Y75 tpr repeat protein DS731_14285 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DS731_14290 ENOG4108YZY peptidylprolyl cis-trans isomerase DS731_14295 ENOG4108YZA Nitrogen regulatory protein pii DS731_14355 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DS731_14360 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase DS731_14365 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DS731_14370 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DS731_14375 ENOG4105DTN riboflavin biosynthesis protein ribF DS731_14380 ENOG4105CJR Integral membrane protein (MviN DS731_14385 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DS731_14420 ENOG410822N TonB family DS731_14425 ENOG4105C0R drug resistance transporter emrb qaca subfamily DS731_14430 ENOG4105CW7 secretion protein, HlyD family DS731_14450 ENOG4105EIN peptidylprolyl cis-trans isomerase DS731_14455 ENOG4105K70 DNA-binding protein DS731_14460 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DS731_14470 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DS731_14475 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DS731_14480 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DS731_14505 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DS731_14530 ENOG4105CJ1 ABC, transporter DS731_14535 ENOG4108R96 Methyltransferase, YaeB family DS731_14540 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DS731_14550 ENOG4105HDD phospholipase DS731_14555 ENOG4105DGU Histone deacetylase DS731_14560 ENOG4105C8Q Methyl-accepting chemotaxis DS731_14565 ENOG4105CIS alcohol dehydrogenase DS731_14570 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) DS731_14575 ENOG4105DQ4 alcohol dehydrogenase DS731_14585 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DS731_14590 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DS731_14595 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DS731_14605 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DS731_14610 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DS731_14615 ENOG4105N21 Membrane DS731_14620 ENOG4105CUT histidyl-tRNA synthetase DS731_14625 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DS731_14640 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DS731_14650 ENOG4105DGW oligopeptidase A DS731_14655 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DS731_14660 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) DS731_14665 ENOG4105VG1 fes assembly suf system protein DS731_14670 ENOG4108Z4V iron-sulfur cluster assembly DS731_14675 ENOG4105C9B Cysteine desulfurase DS731_14680 ENOG4105JRK feS assembly protein SufD DS731_14685 ENOG4105C3K feS assembly ATPase SufC DS731_14695 ENOG4105C3J Cysteine desulfurase DS731_14700 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family DS731_14710 ENOG4105CVS RNA methyltransferase TrmH family, group 1 DS731_14720 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DS731_14725 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DS731_14730 ENOG4105VIE preprotein translocase, subunit YajC DS731_14735 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DS731_14740 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DS731_14755 ENOG4108P9J Phage shock protein A DS731_14780 ENOG4106032 Glutathionylspermidine synthase DS731_14795 ENOG4105G6Z alkaline phosphatase DS731_14800 ENOG4108VYJ response regulator receiver protein DS731_14805 ENOG4107RET Isocitrate lyase DS731_14830 ENOG4105C0H protease DS731_14850 ENOG4105D7W serine acetyltransferase DS731_14855 ENOG4107R8N Glycosyl transferase, family 2 DS731_14865 ENOG4107BJW polysaccharide deacetylase DS731_14870 ENOG4108I69 Glycosyl transferases group 1 DS731_14875 ENOG4105CG5 Glycosyl transferase (Group 1 DS731_14905 ENOG4108QV3 biosynthesis protein DS731_14920 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DS731_14925 ENOG41082IR Excinuclease ABC C subunit domain protein DS731_14935 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DS731_14945 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase DS731_14975 ENOG4107QPN acyl-Coa dehydrogenase DS731_14980 ENOG4105BZU Histidine kinase DS731_14985 ENOG4107104 thymidine kinase DS731_14990 ENOG41066YJ Beta-lactamase DS731_15010 ENOG4105DUM transcriptional regulator, lysR family DS731_15015 ENOG4105GFR rna polymerase sigma factor DS731_15025 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DS731_15030 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DS731_15035 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_15040 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DS731_15070 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) DS731_15075 ENOG4107QMS site-determining protein DS731_15080 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DS731_15105 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) DS731_15110 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) DS731_15115 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d DS731_15120 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E DS731_15135 ENOG4105CKD glutathione-regulated potassium-efflux system protein DS731_15145 ENOG4105E0K tonB-dependent siderophore receptor DS731_15150 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) DS731_15170 ENOG4108M3P Membrane DS731_15195 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family DS731_15200 ENOG4108WUH Transcriptional regulator, TetR family DS731_15205 ENOG4105EMK carboxylate amino acid amine transporter DS731_15220 ENOG4105D8X mechanosensitive ion channel DS731_15230 ENOG4105BZU Histidine kinase DS731_15240 ENOG4105C1J atp-dependent rna helicase DS731_15250 ENOG41088T4 Helicase IV DS731_15255 ENOG4105C5X domain protein DS731_15300 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DS731_15305 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DS731_15310 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DS731_15330 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DS731_15335 ENOG4105D0A hydroxylase DS731_15340 ENOG4107RAQ aminopeptidase DS731_15345 ENOG4105E07 UPF0149 protein DS731_15355 ENOG4108RVA ribokinase DS731_15370 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DS731_15375 ENOG4105E66 phosphoriboisomerase A DS731_15380 ENOG4108JQ1 Dehydrogenase DS731_15395 ENOG4105IYK transposase DS731_15400 ENOG4105DQ6 Transposase DS731_15420 ENOG4105XZD Fe-S protein DS731_15440 ENOG41064T2 transcriptional regulator, lysR family DS731_15445 ENOG4107QN2 dihydrolipoyl dehydrogenase DS731_15450 ENOG4107QSN dihydrolipoamide acetyltransferase DS731_15455 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DS731_15460 ENOG41073TP transcriptional regulator DS731_15470 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DS731_15475 ENOG4108WIW Aspartyl protease DS731_15480 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DS731_15485 ENOG4105KHS type IV fimbrial pilin protein DS731_15490 ENOG4105D7Q type ii secretion system DS731_15500 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DS731_15505 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) DS731_15510 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DS731_15520 ENOG4108N3W hemolysin secretion protein DS731_15525 ENOG4108VYJ response regulator receiver protein DS731_15540 ENOG4105CBS Chea signal transduction histidine kinase DS731_15545 ENOG4108VYJ response regulator receiver protein DS731_15550 ENOG4105BZU Histidine kinase DS731_15560 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DS731_15565 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DS731_15570 ENOG4105C8Q Methyl-accepting chemotaxis DS731_15575 ENOG4105M6F mutator MutT protein DS731_15580 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DS731_15585 ENOG4105E4C Lytic transglycosylase catalytic DS731_15590 ENOG4105BZU Histidine kinase DS731_15595 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DS731_15600 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DS731_15605 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DS731_15610 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) DS731_15615 ENOG4105CPF Cell wall formation (By similarity) DS731_15620 ENOG4105DFU Cell wall formation (By similarity) DS731_15625 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DS731_15630 ENOG4105CNI cell division protein FtsW DS731_15635 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DS731_15640 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DS731_15645 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) DS731_15650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DS731_15655 ENOG4105CJN penicillin-binding protein DS731_15660 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DS731_15665 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DS731_15670 ENOG4108V6E Cell division protein mraZ DS731_15675 ENOG4105NBR Pectinesterase DS731_15690 ENOG4105DKW ABC transporter DS731_15710 ENOG4108IGT Dipeptidase DS731_15715 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) DS731_15720 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DS731_15730 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein DS731_15750 ENOG4105BZU Histidine kinase DS731_15755 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_15760 ENOG4105BZU Histidine kinase DS731_15790 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DS731_15800 ENOG4105D7Z glutathione synthase DS731_15805 ENOG4108UJU UPF0301 protein DS731_15810 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DS731_15820 ENOG4105CZX twitching motility protein DS731_15825 ENOG4105CZX twitching motility protein DS731_15830 ENOG4105DFA alanine racemase domain protein DS731_15835 ENOG4105II7 pyrroline-5-carboxylate reductase DS731_15840 ENOG4108VIA integral membrane protein DS731_15855 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DS731_15875 ENOG4105CIH Imidazole acetol-phosphate transaminase DS731_15880 ENOG4105D1Q UPF0246 protein DS731_15885 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DS731_15890 ENOG4107QP8 phosphohexose isomerase DS731_15900 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DS731_15910 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DS731_15920 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DS731_15925 ENOG4107RNH Outer membrane receptor FepA DS731_15955 ENOG4105EMU Dehydrogenase DS731_15960 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) DS731_15970 ENOG41062D9 Histidine kinase DS731_16010 ENOG4105E3Q saccharopine dehydrogenase DS731_16025 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DS731_16030 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) DS731_16035 ENOG41082RQ UPF0102 protein DS731_16040 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DS731_16045 ENOG4105W4M Transport-associated protein DS731_16060 ENOG4105C0R drug resistance transporter emrb qaca subfamily DS731_16075 ENOG4105CR4 methylisocitrate lyase DS731_16080 ENOG4105BZN citrate synthase DS731_16085 ENOG4108I0Z Aconitate hydratase DS731_16090 ENOG4105C7F AcnD-accessory protein PrpF DS731_16115 ENOG4105BZU Histidine kinase DS731_16120 ENOG4105CBC glutamate synthase DS731_16125 ENOG4105BZ8 glutamate synthase DS731_16150 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DS731_16155 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DS731_16160 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DS731_16175 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DS731_16180 ENOG4105E4C Lytic transglycosylase catalytic DS731_16190 ENOG4108U78 Glutathione S-transferase DS731_16195 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DS731_16200 ENOG4107R3J Transporter DS731_16205 ENOG4105D9P serine threonine protein kinase DS731_16240 ENOG4105C87 Aminotransferase class I and II DS731_16245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_16255 ENOG4105C5F glutamine synthetase DS731_16265 ENOG4105CUX Signal transduction histidine kinase DS731_16270 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_16275 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DS731_16280 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase DS731_16285 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) DS731_16305 ENOG4105BZU Histidine kinase DS731_16310 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DS731_16315 ENOG4105MYG DNA polymerase iii, chi subunit DS731_16320 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DS731_16325 ENOG4108M8S permease YjgP YjgQ family protein DS731_16330 ENOG4108K5H permease YjgP YjgQ family protein DS731_16350 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DS731_16390 ENOG4108J1Q DS731_16420 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) DS731_16430 ENOG4105PGM cation diffusion facilitator family transporter DS731_16475 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DS731_16500 ENOG4105CPN adenine deaminase DS731_16510 ENOG4105QV4 Tryptophan halogenase DS731_16530 ENOG4105CNT hydrolase family 2 DS731_16555 ENOG4105QV4 Tryptophan halogenase DS731_16570 ENOG4105CXK mandelate racemase muconate lactonizing DS731_16575 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) DS731_16585 ENOG4105DT9 hydrolase family 43 DS731_16595 ENOG4105DZ0 fad dependent oxidoreductase DS731_16600 ENOG4108Z4U Ferredoxin DS731_16605 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) DS731_16610 ENOG4108RWN rrna methyltransferase DS731_16630 ENOG4105EGI Transcriptional regulator DS731_16645 ENOG4105C1P efflux transporter, rnd family, mfp subunit DS731_16655 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DS731_16665 ENOG4105C2D reductase DS731_16705 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DS731_16725 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DS731_16755 ENOG4105W8Z 4'-phosphopantetheinyl transferase DS731_16765 ENOG4105BZU Histidine kinase DS731_16795 ENOG4105ETE Transcriptional regulator (LacI family DS731_16825 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DS731_16845 ENOG4108KPZ tonB-dependent Receptor DS731_16850 ENOG4105ETE Transcriptional regulator (LacI family DS731_16860 ENOG4105EGS Mechanosensitive ion channel DS731_16870 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase DS731_16880 ENOG4105D2S major facilitator superfamily DS731_16960 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DS731_16965 ENOG4108ERU trap dicarboxylate transporter subunit DctP DS731_16970 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DS731_16980 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DS731_17005 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_17025 ENOG4105D2S major facilitator superfamily DS731_17030 ENOG4105RQF LysR family Transcriptional regulator DS731_17035 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DS731_17045 ENOG4105D7K pfkb domain protein DS731_17050 ENOG4105TW1 Carbohydrate-selective porin OprB DS731_17055 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) DS731_17060 ENOG4105EDR glucose galactose transporter DS731_17075 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DS731_17080 ENOG4105EW9 transcriptional regulator AsnC family DS731_17115 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DS731_17120 ENOG4107QWP ABC-2 type transporter DS731_17125 ENOG4107QWP ABC-2 type transporter DS731_17130 ENOG4105CJ1 ABC, transporter DS731_17145 ENOG4105CXG d-lactate dehydrogenase DS731_17150 ENOG4105C1J atp-dependent rna helicase DS731_17155 ENOG4105VEQ Cold shock protein DS731_17160 ENOG4105BZU Histidine kinase DS731_17165 ENOG4105BZU Histidine kinase DS731_17205 ENOG4105DFD Na H antiporter DS731_17215 ENOG4105E2S oxidase) subunit II DS731_17220 ENOG4105BZ9 Cytochrome C oxidase, subunit I DS731_17225 ENOG4105CCU oxidase (Subunit III) DS731_17230 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DS731_17235 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DS731_17255 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DS731_17280 ENOG4105X23 Endonuclease Exonuclease phosphatase DS731_17285 ENOG4105DND Transcriptional regulator DS731_17300 ENOG4105HF0 Membrane DS731_17305 ENOG4105CIH Imidazole acetol-phosphate transaminase DS731_17310 ENOG4105C8Q Methyl-accepting chemotaxis DS731_17315 ENOG4108VYJ response regulator receiver protein DS731_17320 ENOG4105CBS Chea signal transduction histidine kinase DS731_17325 ENOG4108V3W Chemotaxis protein, CheW DS731_17330 ENOG4107SDU Methyl-accepting chemotaxis DS731_17335 ENOG4105BZU Histidine kinase DS731_17340 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DS731_17345 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DS731_17360 ENOG4105BZU Histidine kinase DS731_17365 ENOG4105BZU Histidine kinase DS731_17370 ENOG4105CQ2 DNA polymerase DS731_17415 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) DS731_17430 ENOG4105BZU Histidine kinase DS731_17440 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DS731_17450 ENOG4105BZU Histidine kinase DS731_17460 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DS731_17465 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DS731_17470 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DS731_17490 ENOG4105FM1 phage shock protein C DS731_17495 ENOG41087YS Phage shock protein A DS731_17505 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DS731_17515 ENOG4105E0F Histidine kinase DS731_17520 ENOG4105E3W Two component transcriptional regulator (Winged helix family DS731_17530 ENOG4105EYF MMPL domain protein DS731_17535 ENOG4107XDR Lactoylglutathione lyase DS731_17545 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DS731_17565 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DS731_17570 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_17580 ENOG4105C4C beta-galactosidase DS731_17610 ENOG4105BZU Histidine kinase DS731_17615 ENOG4105C4W S-formylglutathione hydrolase DS731_17620 ENOG4106HNH Acyl-transferase DS731_17625 ENOG4106HNH Acyl-transferase DS731_17630 ENOG4105CUY Mechanosensitive ion channel DS731_17645 ENOG4108535 NAD dependent epimerase/dehydratase family DS731_17650 ENOG4105C8J )-transporter DS731_17665 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DS731_17670 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction DS731_17685 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) DS731_17695 ENOG4109015 Biopolymer transport protein exbD tolR DS731_17705 ENOG4105EJG cellulose synthase DS731_17710 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) DS731_17720 ENOG4107QZ7 Cellulose synthase catalytic subunit DS731_17730 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) DS731_17735 ENOG4105K4T epimerase DS731_17745 ENOG4105KWG Pfam:DUF1696 DS731_17750 ENOG4105BZU Histidine kinase DS731_17765 ENOG4105EFZ amidohydrolase DS731_17775 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DS731_17785 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DS731_17795 ENOG4105CJ2 (LipO)protein DS731_17800 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) DS731_17805 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DS731_17810 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DS731_17815 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DS731_17820 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DS731_17825 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DS731_17830 ENOG4105RKW reductase (By DS731_17835 ENOG4108V1T peptidylprolyl cis-trans isomerase DS731_17840 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) DS731_17845 ENOG4105DQ6 Transposase DS731_17850 ENOG4105IYK transposase DS731_17880 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DS731_17885 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DS731_17890 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) DS731_17895 ENOG4105C1P efflux transporter, rnd family, mfp subunit DS731_17900 ENOG4105BZS acriflavin resistance protein DS731_17905 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DS731_17915 ENOG4108KPZ tonB-dependent Receptor DS731_17930 ENOG4105DBI uridine monophosphokinase DS731_17935 ENOG4105D9N nucleoside DS731_17955 ENOG4105E9S glutaredoxin 2 DS731_17960 ENOG4105BZU Histidine kinase DS731_17985 ENOG4105C2X Arabinose 5-phosphate isomerase DS731_17990 ENOG4107QN1 sodium solute DS731_18000 ENOG4105BZU Histidine kinase DS731_18010 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DS731_18020 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DS731_18030 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DS731_18045 ENOG4105CPC Aldo Keto reductase DS731_18055 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DS731_18060 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DS731_18065 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DS731_18070 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DS731_18075 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DS731_18080 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DS731_18085 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DS731_18090 ENOG4108VZM 50s ribosomal protein L10 DS731_18095 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DS731_18100 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DS731_18105 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DS731_18110 ENOG4105PM1 preprotein translocase subunit SecE DS731_18120 ENOG4105BZ1 (ABC) transporter DS731_18125 ENOG4105JSC dimethylmenaquinone methyltransferase DS731_18130 ENOG4105C1J atp-dependent rna helicase DS731_18140 ENOG4105EKE dihydroorotase DS731_18150 ENOG4105QNF Outer membrane lipoprotein DS731_18155 ENOG4107QM2 Aldo Keto reductase DS731_18160 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DS731_18170 ENOG4105DP8 Major facilitator superfamily MFS_1 DS731_18175 ENOG4107QW3 Sucrose phosphorylase DS731_18185 ENOG4105EUJ GTP cyclohydrolase i DS731_18190 ENOG410642E Short chain dehydrogenase DS731_18195 ENOG4105DWY Agmatine deiminase DS731_18215 ENOG4107QRT dEAD DEAH box helicase DS731_18225 ENOG4107T0X DNA ligase DS731_18230 ENOG4108UV7 flagellar protein motX DS731_18240 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DS731_18245 ENOG4107QK7 reductase DS731_18250 ENOG4107VAM peptidase, m28 DS731_18265 ENOG4108XM1 transcriptional regulator AsnC family DS731_18275 ENOG4105CHM Aminotransferase DS731_18280 ENOG4105FQP Beta-lactamase DS731_18295 ENOG4108UVJ appr-1-p processing domain protein DS731_18305 ENOG4105RD7 BadF BadG BcrA BcrD DS731_18310 ENOG4105ETE Transcriptional regulator (LacI family DS731_18320 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DS731_18325 ENOG4107RJ1 sodium solute DS731_18330 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DS731_18335 ENOG4105EHZ conserved protein UCP016719 DS731_18340 ENOG4106G6Q Transcriptional regulator DS731_18410 ENOG4107S6Z Na H antiporter DS731_18415 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DS731_18425 ENOG4105C26 Dehydrogenase DS731_18430 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DS731_18445 ENOG4107QR8 Thioredoxin DS731_18450 ENOG4105CXN decarboxylase DS731_18475 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DS731_18480 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DS731_18485 ENOG4105DUM transcriptional regulator, lysR family DS731_18490 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DS731_18495 ENOG4105BZU Histidine kinase DS731_18500 ENOG4105CH2 amidohydrolase DS731_18510 ENOG4105K63 Thioredoxin DS731_18515 ENOG4105C1J atp-dependent rna helicase DS731_18520 ENOG4105C9X ppx gppa phosphatase DS731_18525 ENOG4105D52 delta-aminolevulinic acid dehydratase DS731_18530 ENOG4106TD9 Diguanylate cyclase DS731_18535 ENOG4105F8V Hydrolase, tatD family DS731_18545 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DS731_18550 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) DS731_18555 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DS731_18565 ENOG4108ZP8 Acetolactate synthase small subunit DS731_18570 ENOG4105C7K acetolactate synthase DS731_18575 ENOG4108WFC UPF0438 protein yifE DS731_18585 ENOG4107RDJ Sulfotransferase DS731_18590 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_18595 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DS731_18610 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) DS731_18615 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DS731_18620 ENOG4105DJ4 phosphatidylserine decarboxylase DS731_18630 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DS731_18640 ENOG4105PXI polysaccharide deacetylase DS731_18645 ENOG41063SB peptidase DS731_18660 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) DS731_18665 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DS731_18675 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DS731_18680 ENOG4105DJY efflux transporter, rnd family, mfp subunit DS731_18685 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DS731_18690 ENOG4108EUD Lysophospholipase DS731_18695 ENOG4105E0F Histidine kinase DS731_18700 ENOG4105E3W Two component transcriptional regulator (Winged helix family DS731_18705 ENOG4108Z5K methylglyoxal synthase DS731_18710 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DS731_18715 ENOG4105CAS nag kinase DS731_18720 ENOG4105DBV ornithine carbamoyltransferase DS731_18725 ENOG4105CDH Citrulline--aspartate ligase DS731_18730 ENOG4105CH7 arginosuccinase DS731_18735 ENOG4107QZM n-acetylglutamate synthase DS731_18770 ENOG4107R1I NAD-dependent malic enzyme DS731_18775 ENOG4108JQC penicillin-binding protein 1A DS731_18780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DS731_18800 ENOG4105E4G Type IV pilus DS731_18805 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DS731_18810 ENOG4105D49 3-dehydroquinate synthase DS731_18820 ENOG4108UPT UPF0178 protein DS731_18825 ENOG4105DFE Dna adenine methylase DS731_18845 ENOG4105DJV ribulose-phosphate 3-epimerase DS731_18850 ENOG4105C31 Tryptophanyl-tRNA synthetase DS731_18855 ENOG4105DDQ anthranilate synthase DS731_18865 ENOG4105C8Y Acetylornithine aminotransferase DS731_18870 ENOG4105F4X arginine DS731_18875 ENOG4105C26 Dehydrogenase DS731_18885 ENOG4105BZU Histidine kinase DS731_18895 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DS731_18905 ENOG4107TDE lipolytic protein G-D-S-L family DS731_18925 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) DS731_18945 ENOG4105EKC DS731_18950 ENOG4105F5H Glycosyl Hydrolase Family 88 DS731_18955 ENOG4105CT4 transporter DS731_18960 ENOG4105CAZ oligogalacturonide lyase DS731_18965 ENOG4105CHR reductase DS731_18975 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DS731_18985 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DS731_19005 ENOG4105D3Y Na H antiporter DS731_19010 ENOG4105CI2 imidazolone-5-propionate hydrolase DS731_19015 ENOG4105C84 Histidine ammonia-lyase DS731_19025 ENOG4105CGP Urocanate hydratase DS731_19030 ENOG4105BZU Histidine kinase DS731_19040 ENOG4105CXT aspartate transcarbamylase DS731_19045 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DS731_19055 ENOG4105EZR dyp-type peroxidase family protein DS731_19060 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DS731_19085 ENOG4108YZA Nitrogen regulatory protein pii DS731_19095 ENOG4105CKW Inner membrane protein yedI DS731_19105 ENOG4105BZ4 penicillin-binding protein DS731_19115 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class DS731_19125 ENOG4108NVM synthesis repressor PhaR DS731_19145 ENOG4105CVE Lytic murein transglycosylase DS731_19150 ENOG4105CHR reductase DS731_19155 ENOG4105CQ7 ATP-dependent helicase DS731_19160 ENOG4105BZU Histidine kinase DS731_19170 ENOG4105CIY formyltetrahydrofolate deformylase DS731_19175 ENOG4105DGW oligopeptidase A DS731_19195 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase DS731_19200 ENOG4105D16 lipopolysaccharide heptosyltransferase i DS731_19205 ENOG4107QPH glycogen) synthase DS731_19210 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DS731_19215 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DS731_19220 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DS731_19225 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DS731_19230 ENOG4105DWT malate dehydrogenase (quinone) DS731_19255 ENOG4105EAA nucleoside DS731_19270 ENOG4105ETE Transcriptional regulator (LacI family DS731_19285 ENOG4107QM5 aconitate hydratase DS731_19305 ENOG4105T16 Transcriptional regulator (AraC family) DS731_19310 ENOG4105CMG Carbohydrate kinase DS731_19315 ENOG4105C93 Xylose Isomerase DS731_19320 ENOG4105CHM Aminotransferase DS731_19330 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DS731_19335 ENOG4105BZU Histidine kinase DS731_19340 ENOG4107SDU Methyl-accepting chemotaxis DS731_19345 ENOG4108V3W Chemotaxis protein, CheW DS731_19350 ENOG4105CBS Chea signal transduction histidine kinase DS731_19355 ENOG4108VYJ response regulator receiver protein DS731_19365 ENOG4107RE3 peptidase, S41 DS731_19385 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) DS731_19390 ENOG4105CEN a g-specific adenine glycosylase DS731_19395 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DS731_19400 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DS731_19405 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) DS731_19410 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DS731_19415 ENOG4105BZU Histidine kinase DS731_19420 ENOG41065U4 response regulator DS731_19425 ENOG4105CMS peptidase U62, modulator of DNA gyrase DS731_19430 ENOG4105N42 UPF0307 protein DS731_19445 ENOG4105D1U peptidase U62 modulator of DNA gyrase DS731_19460 ENOG4105C03 ribonuclease DS731_19465 ENOG4108Z03 MAF-like protein DS731_19470 ENOG4105VQ7 Rod shape-determining protein MreD DS731_19475 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DS731_19480 ENOG4105DFF Rod shape-determining protein mreb DS731_19520 ENOG4105D7Q type ii secretion system DS731_19525 ENOG4107QHF type ii secretion system protein e DS731_19540 ENOG4105GVR general secretion pathway protein D DS731_19570 ENOG4108UW5 maltose o-acetyltransferase DS731_19585 ENOG41064T2 transcriptional regulator, lysR family DS731_19595 ENOG4107XMK single-stranded DNA-binding protein DS731_19605 ENOG4105CNT hydrolase family 2 DS731_19610 ENOG4105CMR udp-glucose 4-epimerase DS731_19630 ENOG4105EQR Transposase IS116 IS110 IS902 DS731_19640 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DS731_19645 ENOG4105F0Z galactose-1-phosphate uridylyltransferase DS731_19650 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DS731_19655 ENOG41060NJ transcriptional regulator DS731_19670 ENOG4107QWE )-transporter DS731_19685 ENOG4107RDB Major Facilitator DS731_19710 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit DS731_19715 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding DS731_19720 ENOG4105C7W Xanthine dehydrogenase DS731_19735 ENOG4105PGM cation diffusion facilitator family transporter DS731_19740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DS731_19745 ENOG4108JJ9 ABC, transporter DS731_19755 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DS731_19760 ENOG4105C4M (Ubiquinol oxidase) subunit I DS731_19765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DS731_19780 ENOG4105EFX secretion protein, HlyD family DS731_19810 ENOG4107SDU Methyl-accepting chemotaxis DS731_19835 ENOG4105BZU Histidine kinase DS731_19880 ENOG4108YZN class I peptide chain release factor DS731_19895 ENOG4105CEP NADH dehydrogenase DS731_19910 ENOG4105C26 Dehydrogenase DS731_19915 ENOG4108HW3 (ABC) transporter DS731_19925 ENOG4105D7T ABC transporter DS731_19935 ENOG4105BZU Histidine kinase DS731_19940 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DS731_19955 ENOG4105CJ1 ABC, transporter DS731_19960 ENOG4105DA5 (ABC) transporter DS731_19985 ENOG4105DZG Dehydrogenase DS731_20005 ENOG4105HEI LysR family (Transcriptional regulator DS731_20010 ENOG4105F27 Major Facilitator DS731_20025 ENOG4106F60 Histidine kinase DS731_20030 ENOG4105XJC Two component transcriptional regulator (Winged helix family DS731_20035 ENOG4105BZS acriflavin resistance protein DS731_20045 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DS731_20080 ENOG4105JQN Transcriptional regulator DS731_20085 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DS731_20090 ENOG4105CKK Glycosyl transferase, family 2 DS731_20100 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) DS731_20115 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DS731_20120 ENOG4108VKM cytochrome b561 DS731_20125 ENOG4107SDU Methyl-accepting chemotaxis DS731_20135 ENOG4105CC0 LysR family Transcriptional regulator DS731_20145 ENOG4105CSR polyphosphate kinase 2 DS731_20155 ENOG4105CM2 brancheD-chain amino acid aminotransferase DS731_20170 ENOG41069YE inner membrane protein yohC DS731_20175 ENOG4105D5D udp-galactopyranose mutase DS731_20180 ENOG4105CBN LysR family transcriptional regulator DS731_20220 ENOG4105KHS type IV fimbrial pilin protein DS731_20235 ENOG4105QV4 Tryptophan halogenase DS731_20240 ENOG4107ENK receptor DS731_20255 ENOG4105CTM Glycoside hydrolase family 5 DS731_20270 ENOG4105CTM Glycoside hydrolase family 5 DS731_20285 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DS731_20315 ENOG4105ES4 Nitrilase DS731_20320 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DS731_20330 ENOG4105D9R oxidoreductase DS731_20340 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DS731_20345 ENOG4105BZU Histidine kinase DS731_20365 ENOG4107EJG GntR family transcriptional regulator DS731_20385 ENOG4105BZU Histidine kinase DS731_20390 ENOG4105WH1 Two component transcriptional regulator luxr family DS731_20395 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) DS731_20400 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase DS731_20405 ENOG4108V1T peptidylprolyl cis-trans isomerase DS731_20415 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) DS731_20420 ENOG4105CT4 transporter DS731_20435 ENOG4106Z5D Glycoside Hydrolase Family 43 DS731_20445 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DS731_20455 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DS731_20460 ENOG4107VXZ Hydrolase DS731_20475 ENOG4105EF1 ribulokinase DS731_20480 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DS731_20485 ENOG4105CV1 Transketolase (EC 2.2.1.1) DS731_20500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DS731_20520 ENOG4105BZU Histidine kinase DS731_20530 ENOG4107R6D beta-lactam binding protein AmpH DS731_20535 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) DS731_20540 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DS731_20550 ENOG4105D05 Receptor DS731_20555 ENOG4108RCM Nitroreductase DS731_20560 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DS731_20585 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DS731_20590 ENOG4105W8H transhydrogenase (subunit alpha DS731_20595 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DS731_20600 ENOG4105KQ5 peptidylprolyl cis-trans isomerase DS731_20610 ENOG4105BZU Histidine kinase DS731_20625 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DS731_20630 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DS731_20640 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DS731_20645 ENOG4108KPZ tonB-dependent Receptor DS731_20660 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DS731_20665 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DS731_20670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DS731_20690 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DS731_20735 ENOG4109015 Biopolymer transport protein exbD tolR DS731_20745 ENOG4105M8K biopolymer transport protein DS731_20755 ENOG4107RNH Outer membrane receptor FepA DS731_20765 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DS731_20770 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DS731_20775 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) DS731_20780 ENOG4105DC1 bifunctional purine biosynthesis protein purh DS731_20790 ENOG4105C12 Phosphoribosylglycinamide synthetase DS731_20800 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) DS731_20810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DS731_20815 ENOG4105E0F Histidine kinase DS731_20835 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DS731_20840 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DS731_20845 ENOG4105VEJ Heat shock protein DS731_20850 ENOG4108XKW General secretion pathway protein C DS731_20860 ENOG4107QHF type ii secretion system protein e DS731_20865 ENOG4105D7Q type ii secretion system DS731_20870 ENOG4108VAU general secretion pathway protein G DS731_20875 ENOG4105VWV general secretion pathway protein h DS731_20890 ENOG4108RTD type II secretion system protein K DS731_20900 ENOG4105U1E general secretion pathway protein M DS731_20915 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DS731_20920 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 DS731_20925 ENOG4107RK2 ADP-ribose diphosphatase NudE DS731_20945 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) DS731_20950 ENOG4105DJ9 glucan biosynthesis protein DS731_20960 ENOG4108WAV Transcriptional regulator DS731_20970 ENOG4105YP7 UPF0270 protein DS731_20975 ENOG4105DNZ Alpha Beta Hydrolase DS731_20985 ENOG4105C5H ABC transporter DS731_20990 ENOG4105VKU nucleicacid-binding protein DS731_21005 ENOG41069P5 Protein slyX homolog DS731_21015 ENOG4108V1T peptidylprolyl cis-trans isomerase DS731_21020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DS731_21025 ENOG4108Z0Z intracellular protease Pfpi family DS731_21035 ENOG4108RRZ Transcription elongation factor GreB DS731_21050 ENOG41062A4 Transcriptional regulator DS731_21055 ENOG4105BZM domain protein DS731_21060 ENOG4105DQ6 Transposase DS731_21065 ENOG4105IYK transposase DS731_21070 ENOG4105BZU Histidine kinase DS731_21085 ENOG4108J20 pectate lyase DS731_21105 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DS731_21120 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) DS731_21130 ENOG4107R73 Mate efflux family protein DS731_21150 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DS731_21155 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) DS731_21180 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) DS731_21185 ENOG4105BZ9 Cytochrome C oxidase, subunit I DS731_21190 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) DS731_21195 ENOG4108YYC ycei family DS731_21205 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DS731_21210 ENOG4107RSM transcriptional regulator DS731_21220 ENOG4105CT4 transporter DS731_21225 ENOG4105ETE Transcriptional regulator (LacI family DS731_21235 ENOG4105CBG Sulfatase DS731_21240 ENOG4105CBG Sulfatase DS731_21245 ENOG41061MV Arylsulfatase DS731_21265 ENOG4105E55 glycerol-3-phosphate acyltransferase DS731_21275 ENOG4105C7B Threonine dehydratase DS731_21280 ENOG4105C01 Dihydroxy-acid dehydratase DS731_21285 ENOG4105CM2 brancheD-chain amino acid aminotransferase DS731_21290 ENOG4105EN6 Membrane DS731_21295 ENOG4105C0P Mg chelatase subunit ChlI DS731_21300 ENOG4105EMY transcriptional regulator DS731_21305 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DS731_21315 ENOG4105C2C drug resistance transporter, Bcr CflA DS731_21320 ENOG4105CFU surface antigen DS731_21325 ENOG4105MA0 exported protein DS731_21330 ENOG4105DEN Luciferase family DS731_21350 ENOG4105C5I Dehydrogenase DS731_21360 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DS731_21400 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DS731_21425 ENOG4105IYK transposase DS731_21430 ENOG4105DQ6 Transposase DS731_21435 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DS731_21440 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DS731_21445 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DS731_21455 ENOG4105DSJ YicC domain protein DS731_21465 ENOG41090BB DNA mismatch endonuclease (vsr) DS731_21475 ENOG4105CDV Ompa motb domain protein DS731_21480 ENOG4105CPI Metal Dependent Phosphohydrolase DS731_21495 ENOG4108RXX maleylacetoacetate isomerase DS731_21515 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DS731_21520 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DS731_21525 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DS731_21530 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DS731_21535 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DS731_21540 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DS731_21545 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DS731_21550 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) DS731_21560 ENOG4105FA0 parb-like partition protein DS731_21565 ENOG4107QJE Chromosome Partitioning Protein DS731_21570 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DS731_21575 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DS731_21590 ENOG4105QTB Flavodoxin DS731_21600 ENOG4108VPT UPF0234 protein DS731_21605 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DS731_21610 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DS731_21615 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DS731_21620 ENOG4105VG0 50S ribosomal protein l34 DS731_21725 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_21735 ENOG4105BZU Histidine kinase DS731_21775 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_21840 ENOG4105BZ9 Cytochrome C oxidase, subunit I DS731_21845 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) DS731_21865 ENOG4105BZU Histidine kinase DS731_21875 ENOG4105VW4 glutaredoxin 3 DS731_21900 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DS731_21910 ENOG4105C4M (Ubiquinol oxidase) subunit I DS731_21915 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DS731_21935 ENOG4107SDU Methyl-accepting chemotaxis DS731_21945 ENOG4105BZU Histidine kinase DS731_21945 ENOG4105BZU Histidine kinase DS731_21975 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) DS731_21980 ENOG4107SKI cobyrinic Acid a,c-diamide synthase DS731_22085 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DS731_22095 ENOG4105BZU Histidine kinase DS731_22140 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)