locus-tag	class	description
DS731_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DS731_00020	COG0187	DNA topoisomerase II activity
DS731_00045	COG2818	Glycosylase
DS731_00055	COG3078	GTPase activator activity
DS731_00075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_00075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_00080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DS731_00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DS731_00090	COG0569	domain protein
DS731_00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DS731_00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DS731_00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DS731_00110	COG1652	LysM domain
DS731_00115	COG0758	DNA mediated transformation
DS731_00125	COG0551	DNA topoisomerase type I activity
DS731_00130	COG0009	L-threonylcarbamoyladenylate synthase
DS731_00135	COG0408	coproporphyrinogen oxidase activity
DS731_00140	COG3047	cAMP biosynthetic process
DS731_00155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DS731_00205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DS731_00210	COG0587	DNA-directed DNA polymerase activity
DS731_00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DS731_00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_00310	COG0859	PFAM glycosyl transferase family 9
DS731_00330	COG0156	8-amino-7-oxononanoate synthase activity
DS731_00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS731_00355	COG3161	chorismate lyase activity
DS731_00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DS731_00365	COG2960	long-chain fatty acid transporting porin activity
DS731_00370	COG0210	DNA helicase
DS731_00390	COG1216	Glycosyl transferase, family 2
DS731_00390	COG0463	Glycosyl transferase, family 2
DS731_00400	COG0297	glycogen (starch) synthase activity
DS731_00400	COG0438	transferase activity, transferring glycosyl groups
DS731_00405	COG2244	polysaccharide biosynthetic process
DS731_00470	COG0514	ATP-dependent DNA helicase (RecQ)
DS731_00515	COG0720	synthase
DS731_00595	COG0463	Glycosyl transferase, family 2
DS731_00600	COG2207	Transcriptional regulator
DS731_00615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_00615	COG4191	Histidine kinase
DS731_00625	COG0656	L-ascorbic acid biosynthetic process
DS731_00635	COG4771	TonB-dependent receptor
DS731_00640	COG3250	beta-galactosidase activity
DS731_00650	COG0024	Methionine aminopeptidase
DS731_00690	COG3347	Dehydrogenase
DS731_00690	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_00695	COG4952	isomerase
DS731_00700	COG1304	FMN binding
DS731_00745	COG0531	amino acid
DS731_00765	COG1309	transcriptional regulator
DS731_00820	COG1609	Transcriptional regulator
DS731_00830	COG4771	TonB-dependent receptor
DS731_00850	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_00860	COG4771	TonB-dependent receptor
DS731_00865	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_00880	COG2814	Major facilitator Superfamily
DS731_00885	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_00895	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_00905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_00950	COG4771	TonB-dependent receptor
DS731_00960	COG4771	TonB-dependent receptor
DS731_00965	COG2272	Belongs to the type-B carboxylesterase lipase family
DS731_00990	COG2072	flavoprotein involved in K transport
DS731_01000	COG2144	transferase activity, transferring acyl groups
DS731_01025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS731_01030	COG0348	domain, Protein
DS731_01035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS731_01040	COG1271	oxidase subunit
DS731_01045	COG1294	oxidase, subunit
DS731_01070	COG2814	Major facilitator Superfamily
DS731_01115	COG4771	TonB-dependent receptor
DS731_01120	COG0583	DNA-binding transcription factor activity
DS731_01125	COG2076	Multidrug Resistance protein
DS731_01140	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DS731_01160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_01165	COG4771	TonB-dependent receptor
DS731_01170	COG4774	siderophore transport
DS731_01180	COG3384	dioxygenase
DS731_01185	COG2814	Major facilitator Superfamily
DS731_01190	COG0583	DNA-binding transcription factor activity
DS731_01195	COG2211	Major facilitator Superfamily
DS731_01200	COG3622	Belongs to the hyi family
DS731_01205	COG1082	Xylose isomerase domain protein TIM barrel
DS731_01230	COG3119	arylsulfatase activity
DS731_01235	COG2186	Transcriptional regulator
DS731_01240	COG0840	transmembrane signaling receptor activity
DS731_01265	COG4773	Receptor
DS731_01280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DS731_01295	COG1178	ABC-type Fe3 transport system permease component
DS731_01300	COG3842	ATPase activity
DS731_01305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DS731_01360	COG5002	protein histidine kinase activity
DS731_01375	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DS731_01380	COG0583	DNA-binding transcription factor activity
DS731_01390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_01405	COG0179	Fumarylacetoacetate (FAA) hydrolase
DS731_01415	COG2205	protein histidine kinase activity
DS731_01420	COG0745	RESPONSE REGULATOR receiver
DS731_01425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_01430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_01460	COG4206	TonB-dependent receptor
DS731_01480	COG0667	Aldo Keto reductase
DS731_01495	COG3119	arylsulfatase activity
DS731_01525	COG1764	response to oxidative stress
DS731_01530	COG1846	Transcriptional regulator
DS731_01535	COG0840	transmembrane signaling receptor activity
DS731_01545	COG3177	Filamentation induced by cAMP protein fic
DS731_01550	COG0277	FAD linked oxidase domain protein
DS731_01575	COG1566	PFAM secretion protein HlyD family protein
DS731_01580	COG1289	transmembrane transporter activity
DS731_01585	COG1312	Catalyzes the dehydration of D-mannonate
DS731_01605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DS731_01610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DS731_01615	COG2971	BadF BadG BcrA BcrD
DS731_01640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DS731_01650	COG2610	gluconate transmembrane transporter activity
DS731_01655	COG3265	gluconokinase activity
DS731_01660	COG1609	Transcriptional regulator
DS731_01675	COG3106	COG3106 Predicted ATPase
DS731_01685	COG0668	transmembrane transport
DS731_01705	COG1192	Involved in chromosome partitioning
DS731_01730	COG0438	transferase activity, transferring glycosyl groups
DS731_01760	COG3123	guanosine phosphorylase activity
DS731_01790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DS731_01795	COG4771	TonB-dependent receptor
DS731_01800	COG2755	lipolytic protein G-D-S-L family
DS731_01810	COG4771	TonB-dependent receptor
DS731_01830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS731_01835	COG0800	Aldolase
DS731_01840	COG0246	Mannitol dehydrogenase
DS731_01845	COG1904	glucuronate isomerase
DS731_01850	COG2721	sulfolactate sulfo-lyase activity
DS731_01865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DS731_01880	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_01890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DS731_01905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DS731_01910	COG0352	thiamine-phosphate diphosphorylase activity
DS731_01940	COG4771	TonB-dependent receptor
DS731_01945	COG0402	S-adenosylhomocysteine deaminase activity
DS731_01955	COG2959	enzyme of heme biosynthesis
DS731_01960	COG1587	Uroporphyrinogen-III synthase
DS731_01965	COG0181	hydroxymethylbilane synthase activity
DS731_01975	COG0194	GDP metabolic process
DS731_01985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DS731_02000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DS731_02010	COG0678	peroxiredoxin activity
DS731_02015	COG2197	response regulator
DS731_02020	COG2081	HI0933 family
DS731_02040	COG2832	Protein of unknown function (DUF454)
DS731_02045	COG0484	heat shock protein binding
DS731_02050	COG1309	transcriptional regulator
DS731_02055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_02065	COG0427	acetyl-CoA hydrolase
DS731_02070	COG0123	including yeast histone deacetylase and acetoin utilization protein
DS731_02080	COG0840	transmembrane signaling receptor activity
DS731_02100	COG3064	Membrane
DS731_02110	COG5002	protein histidine kinase activity
DS731_02110	COG5001	Diguanylate cyclase
DS731_02120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DS731_02135	COG2239	Acts as a magnesium transporter
DS731_02140	COG2962	Rard protein
DS731_02145	COG3706	GGDEF domain
DS731_02150	COG0210	DNA helicase
DS731_02160	COG1295	ribonuclease BN
DS731_02165	COG3237	CsbD-like
DS731_02175	COG1011	Hydrolase
DS731_02180	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DS731_02190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DS731_02195	COG0019	diaminopimelate decarboxylase activity
DS731_02210	COG0671	phosphoesterase, PA-phosphatase related
DS731_02225	COG0163	prenyltransferase activity
DS731_02230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DS731_02240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DS731_02245	COG4191	Histidine kinase
DS731_02250	COG0840	transmembrane signaling receptor activity
DS731_02260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DS731_02265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS731_02280	COG0583	DNA-binding transcription factor activity
DS731_02295	COG0004	ammonium transporteR
DS731_02300	COG0697	spore germination
DS731_02305	COG0583	DNA-binding transcription factor activity
DS731_02315	COG2201	protein-glutamate methylesterase activity
DS731_02330	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DS731_02360	COG0089	rRNA binding
DS731_02370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DS731_02380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DS731_02395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DS731_02405	COG2258	MOSC domain
DS731_02425	COG0305	Participates in initiation and elongation during chromosome replication
DS731_02435	COG0432	Pfam Uncharacterised protein family UPF0047
DS731_02445	COG0735	belongs to the Fur family
DS731_02455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DS731_02465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DS731_02465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DS731_02470	COG0802	atpase or kinase
DS731_02485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DS731_02490	COG1923	regulation of RNA biosynthetic process
DS731_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DS731_02500	COG0330	HflC and HflK could
DS731_02505	COG0330	HflC and HflK could
DS731_02510	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DS731_02515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DS731_02530	COG1012	belongs to the aldehyde dehydrogenase family
DS731_02535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DS731_02545	COG0557	exoribonuclease II activity
DS731_02555	COG4206	TonB-dependent receptor
DS731_02565	COG0784	Response regulator, receiver
DS731_02565	COG2205	protein histidine kinase activity
DS731_02600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DS731_02615	COG0200	Binds to the 23S rRNA
DS731_02620	COG0201	protein transport
DS731_02645	COG0202	RNA polymerase activity
DS731_02695	COG1442	glycosyl transferase family 8
DS731_02695	COG1216	Glycosyl transferase, family 2
DS731_02705	COG0463	Glycosyl transferase, family 2
DS731_02735	COG0438	transferase activity, transferring glycosyl groups
DS731_02735	COG1216	Glycosyl transferase, family 2
DS731_02775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DS731_02785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DS731_02825	COG3706	GGDEF domain
DS731_02830	COG1966	Carbon starvation protein
DS731_02835	COG1253	flavin adenine dinucleotide binding
DS731_02840	COG2205	protein histidine kinase activity
DS731_02845	COG0745	RESPONSE REGULATOR receiver
DS731_02855	COG1131	(ABC) transporter
DS731_02860	COG0842	Transport permease protein
DS731_02865	COG4106	trans-aconitate 2-methyltransferase activity
DS731_02875	COG0076	glutamate decarboxylase activity
DS731_02890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DS731_02895	COG0617	tRNA 3'-terminal CCA addition
DS731_02905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DS731_02925	COG2095	MarC family integral membrane protein
DS731_02930	COG3068	Protein conserved in bacteria
DS731_02935	COG0742	ribosomal rna small subunit methyltransferase
DS731_02940	COG0552	protein localization to endoplasmic reticulum
DS731_02945	COG2884	Cell division ATP-binding protein ftsE
DS731_02950	COG2177	Part of the ABC transporter FtsEX involved in
DS731_02955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DS731_02960	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DS731_02975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DS731_02985	COG0456	acetyltransferase
DS731_03015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DS731_03025	COG2814	Major facilitator Superfamily
DS731_03030	COG0281	malic enzyme
DS731_03040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DS731_03055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DS731_03065	COG0583	DNA-binding transcription factor activity
DS731_03070	COG1902	pentaerythritol trinitrate reductase activity
DS731_03090	COG2197	response regulator
DS731_03100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_03130	COG1335	isochorismatase
DS731_03135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DS731_03145	COG5290	Psort location Cytoplasmic, score
DS731_03205	COG0789	Transcriptional regulator
DS731_03210	COG4977	sequence-specific DNA binding
DS731_03235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS731_03240	COG4191	Histidine kinase
DS731_03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_03260	COG2201	protein-glutamate methylesterase activity
DS731_03270	COG0339	signal peptide processing
DS731_03290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DS731_03295	COG1278	Cold shock
DS731_03310	COG0183	Belongs to the thiolase family
DS731_03315	COG1250	3-hydroxyacyl-CoA dehydrogenase
DS731_03315	COG1024	Enoyl-CoA hydratase
DS731_03325	COG0006	proline dipeptidase activity
DS731_03335	COG0142	geranyltranstransferase activity
DS731_03360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DS731_03370	COG1238	metal cluster binding
DS731_03380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DS731_03385	COG0585	pseudouridine synthase activity
DS731_03400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DS731_03410	COG0840	transmembrane signaling receptor activity
DS731_03425	COG3025	triphosphatase activity
DS731_03435	COG3066	DNA modification
DS731_03440	COG0494	nUDIX hydrolase
DS731_03455	COG0730	response to heat
DS731_03460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DS731_03465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DS731_03470	COG2201	protein-glutamate methylesterase activity
DS731_03475	COG3706	GGDEF domain
DS731_03480	COG0784	Response regulator, receiver
DS731_03480	COG2205	protein histidine kinase activity
DS731_03500	COG0564	pseudouridine synthase activity
DS731_03510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DS731_03520	COG1648	precorrin-2 dehydrogenase activity
DS731_03520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DS731_03540	COG1538	Outer membrane efflux protein
DS731_03545	COG0494	nUDIX hydrolase
DS731_03550	COG3151	Protein conserved in bacteria
DS731_03555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DS731_03560	COG3150	esterase
DS731_03575	COG1280	lysine exporter protein (LysE YggA)
DS731_03580	COG2153	protein acetylation
DS731_03585	COG4191	Histidine kinase
DS731_03585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_03595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DS731_03615	COG1509	lysine 2,3-aminomutase activity
DS731_03625	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DS731_03630	COG4771	TonB-dependent receptor
DS731_03635	COG0519	Catalyzes the synthesis of GMP from XMP
DS731_03655	COG0271	Belongs to the BolA IbaG family
DS731_03670	COG0679	Auxin Efflux Carrier
DS731_03675	COG0671	phosphoesterase, PA-phosphatase related
DS731_03680	COG3707	response regulator
DS731_03685	COG2116	formate transmembrane transporter activity
DS731_03690	COG2815	serine threonine protein kinase
DS731_03690	COG0515	serine threonine protein kinase
DS731_03695	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DS731_03710	COG1764	response to oxidative stress
DS731_03715	COG0659	secondary active sulfate transmembrane transporter activity
DS731_03720	COG2146	nitrite reductase [NAD(P)H] activity
DS731_03720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS731_03725	COG2146	nitrite reductase [NAD(P)H] activity
DS731_03730	COG0243	molybdopterin cofactor binding
DS731_03735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DS731_03735	COG1648	precorrin-2 dehydrogenase activity
DS731_03740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS731_03750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS731_03750	COG1116	anion transmembrane transporter activity
DS731_03755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS731_03760	COG1116	anion transmembrane transporter activity
DS731_03770	COG0746	molybdenum cofactor guanylyltransferase activity
DS731_03775	COG3706	GGDEF domain
DS731_03785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DS731_03790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS731_03815	COG2356	endonuclease I
DS731_03820	COG1960	acyl-CoA dehydrogenase activity
DS731_03840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DS731_03845	COG0569	domain protein
DS731_03850	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_03865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_03870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_03875	COG0500	methyltransferase
DS731_03880	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_03890	COG2223	nitrite transmembrane transporter activity
DS731_03895	COG4172	Belongs to the ABC transporter superfamily
DS731_03900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DS731_03905	COG0601	transmembrane transport
DS731_03910	COG0747	negative chemotaxis
DS731_03915	COG0656	L-ascorbic acid biosynthetic process
DS731_03925	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_03935	COG0583	DNA-binding transcription factor activity
DS731_03940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DS731_03945	COG0358	DNA primase activity
DS731_03950	COG1610	YqeY-like protein
DS731_03975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DS731_03995	COG0537	adenosine 5'-monophosphoramidase activity
DS731_04020	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DS731_04025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS731_04030	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DS731_04035	COG1492	cobalamin metabolic process
DS731_04050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DS731_04055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DS731_04060	COG4139	cobalamin transport
DS731_04065	COG1120	ATPase activity
DS731_04075	COG3135	benzoate transporter
DS731_04080	COG2974	May be involved in recombination
DS731_04085	COG4191	Histidine kinase
DS731_04085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_04090	COG0745	RESPONSE REGULATOR receiver
DS731_04095	COG5002	protein histidine kinase activity
DS731_04120	COG0811	peptide transport
DS731_04125	COG0811	peptide transport
DS731_04130	COG0848	biopolymer transport protein
DS731_04135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DS731_04160	COG2205	protein histidine kinase activity
DS731_04160	COG5002	protein histidine kinase activity
DS731_04160	COG0784	Response regulator, receiver
DS731_04175	COG2133	pyrroloquinoline quinone binding
DS731_04190	COG0527	aspartate kinase activity
DS731_04195	COG2207	Transcriptional regulator
DS731_04205	COG2203	Gaf domain
DS731_04205	COG3706	GGDEF domain
DS731_04205	COG5001	Diguanylate cyclase
DS731_04205	COG4251	negative regulation of phosphorylation
DS731_04210	COG0840	transmembrane signaling receptor activity
DS731_04215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DS731_04220	COG2967	ApaG domain
DS731_04230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DS731_04235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS731_04240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DS731_04245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DS731_04250	COG4974	Belongs to the 'phage' integrase family
DS731_04265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DS731_04285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DS731_04290	COG0736	holo-[acyl-carrier-protein] synthase activity
DS731_04295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DS731_04300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DS731_04305	COG3956	TIGRFAM MazG family protein
DS731_04320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DS731_04325	COG1473	amidohydrolase
DS731_04330	COG0723	plastoquinol--plastocyanin reductase activity
DS731_04335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DS731_04340	COG2857	Cytochrome c1
DS731_04345	COG0625	glutathione transferase activity
DS731_04350	COG2969	positive regulation of protein catabolic process
DS731_04365	COG0745	RESPONSE REGULATOR receiver
DS731_04370	COG2239	Acts as a magnesium transporter
DS731_04390	COG4682	membrane
DS731_04400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS731_04420	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DS731_04425	COG1137	ATPase activity
DS731_04440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DS731_04460	COG1127	ABC transporter
DS731_04465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DS731_04470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DS731_04475	COG2854	intermembrane phospholipid transfer
DS731_04485	COG5007	Belongs to the BolA IbaG family
DS731_04495	COG2205	protein histidine kinase activity
DS731_04500	COG0745	RESPONSE REGULATOR receiver
DS731_04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS731_04520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS731_04530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DS731_04595	COG1132	(ABC) transporter
DS731_04635	COG0784	Response regulator, receiver
DS731_04635	COG2205	protein histidine kinase activity
DS731_04650	COG1794	racemase activity, acting on amino acids and derivatives
DS731_04665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DS731_04675	COG0126	phosphoglycerate kinase activity
DS731_04680	COG3588	fructose-bisphosphate aldolase
DS731_04690	COG0248	Ppx GppA phosphatase
DS731_04695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DS731_04705	COG0573	inorganic phosphate transmembrane transporter activity
DS731_04725	COG0306	phosphate transporter
DS731_04730	COG0589	response to stress
DS731_04755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DS731_04770	COG0489	protein tyrosine kinase activity
DS731_04830	COG0121	glutamine amidotransferase
DS731_04850	COG1272	protein, Hemolysin III
DS731_04865	COG1846	Transcriptional regulator
DS731_04870	COG0154	amidase activity
DS731_04890	COG4638	Rieske (2fe-2S)
DS731_04900	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_04905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DS731_04910	COG1942	4-Oxalocrotonate Tautomerase
DS731_04915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DS731_04920	COG1473	amidohydrolase
DS731_04940	COG2271	Major facilitator Superfamily
DS731_04955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS731_04960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS731_04965	COG1017	nitric oxide dioxygenase activity
DS731_04965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DS731_04970	COG3604	Transcriptional regulator
DS731_04980	COG2801	Transposase and inactivated derivatives
DS731_05005	COG4221	oxidoreductase activity
DS731_05010	COG0583	DNA-binding transcription factor activity
DS731_05015	COG1739	Uncharacterized protein family UPF0029
DS731_05030	COG5001	Diguanylate cyclase
DS731_05030	COG3300	MHYT domain
DS731_05050	COG2885	chlorophyll binding
DS731_05070	COG0745	RESPONSE REGULATOR receiver
DS731_05070	COG4191	Histidine kinase
DS731_05070	COG2205	protein histidine kinase activity
DS731_05075	COG3437	response regulator, receiver
DS731_05075	COG0784	Response regulator, receiver
DS731_05080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_05080	COG4191	Histidine kinase
DS731_05085	COG2200	EAL domain
DS731_05085	COG2203	Gaf domain
DS731_05085	COG2199	diguanylate cyclase activity
DS731_05095	COG0420	3'-5' exonuclease activity
DS731_05100	COG0419	ATPase involved in DNA repair
DS731_05140	COG0701	Predicted permease
DS731_05145	COG0789	Transcriptional regulator
DS731_05160	COG2205	protein histidine kinase activity
DS731_05170	COG0488	(ABC) transporter
DS731_05185	COG1451	nucleotide metabolic process
DS731_05195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DS731_05210	COG5002	protein histidine kinase activity
DS731_05215	COG1472	Belongs to the glycosyl hydrolase 3 family
DS731_05220	COG2723	6-phospho-beta-galactosidase activity
DS731_05230	COG0477	Major facilitator Superfamily
DS731_05230	COG2814	Major facilitator Superfamily
DS731_05265	COG2851	Citrate transporter
DS731_05275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS731_05285	COG0583	DNA-binding transcription factor activity
DS731_05330	COG4774	siderophore transport
DS731_05410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_05430	COG0789	Transcriptional regulator
DS731_05435	COG2217	Heavy metal translocating P-type atpase
DS731_05470	COG0531	amino acid
DS731_05480	COG2132	Multicopper oxidase
DS731_05505	COG0583	DNA-binding transcription factor activity
DS731_05510	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_05515	COG3485	protocatechuate 3,4-dioxygenase
DS731_05540	COG3135	benzoate transporter
DS731_05545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DS731_05585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DS731_05590	COG0183	Belongs to the thiolase family
DS731_05595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DS731_05600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DS731_05605	COG1414	Transcriptional regulator
DS731_05610	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_05625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DS731_05635	COG3284	Transcriptional regulator
DS731_05660	COG0596	Alpha beta hydrolase
DS731_05670	COG0179	Fumarylacetoacetate (FAA) hydrolase
DS731_05685	COG0477	Major facilitator Superfamily
DS731_05695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DS731_05700	COG4774	siderophore transport
DS731_05705	COG2211	Major facilitator Superfamily
DS731_05755	COG1380	Effector of murein hydrolase LrgA
DS731_05760	COG1346	cytolysis
DS731_05790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DS731_05800	COG0513	Belongs to the DEAD box helicase family
DS731_05805	COG0514	ATP-dependent DNA helicase (RecQ)
DS731_05820	COG3409	Peptidoglycan-binding domain 1 protein
DS731_05820	COG3267	Type II secretory pathway component ExeA
DS731_05845	COG0473	3-isopropylmalate dehydrogenase activity
DS731_05850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DS731_05900	COG4133	protoheme IX ABC transporter activity
DS731_05905	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS731_05910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS731_05915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS731_05925	COG1138	Cytochrome C-type biogenesis protein
DS731_05930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS731_05935	COG4235	cytochrome complex assembly
DS731_05935	COG3088	subunit of a heme lyase
DS731_05945	COG2853	Lipoprotein
DS731_05950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DS731_05960	COG3104	oligopeptide transport
DS731_05995	COG1216	Glycosyl transferase, family 2
DS731_06005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DS731_06010	COG1555	photosystem II stabilization
DS731_06010	COG1596	polysaccharide export
DS731_06015	COG0473	3-isopropylmalate dehydrogenase activity
DS731_06030	COG1611	Belongs to the LOG family
DS731_06035	COG0745	RESPONSE REGULATOR receiver
DS731_06035	COG3706	GGDEF domain
DS731_06040	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DS731_06040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DS731_06100	COG0024	Methionine aminopeptidase
DS731_06110	COG0052	Belongs to the universal ribosomal protein uS2 family
DS731_06120	COG0528	UMP kinase activity
DS731_06130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DS731_06135	COG0575	Belongs to the CDS family
DS731_06140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DS731_06145	COG0750	zinc metalloprotease
DS731_06160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DS731_06165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS731_06180	COG0587	DNA-directed DNA polymerase activity
DS731_06185	COG0825	malonyl-CoA metabolic process
DS731_06190	COG0037	tRNA processing
DS731_06195	COG3706	GGDEF domain
DS731_06210	COG0590	tRNA wobble adenosine to inosine editing
DS731_06215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DS731_06220	COG0047	phosphoribosylformylglycinamidine synthase activity
DS731_06220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DS731_06260	COG0835	chemotaxis
DS731_06260	COG0784	Response regulator, receiver
DS731_06265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DS731_06270	COG1815	bacterial-type flagellum-dependent cell motility
DS731_06275	COG1558	bacterial-type flagellum-dependent cell motility
DS731_06280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DS731_06285	COG1749	Flagellar hook protein flgE
DS731_06290	COG4786	Flagellar basal body rod
DS731_06295	COG4786	Flagellar basal body rod
DS731_06310	COG3951	Flagellar rod assembly protein muramidase FlgJ
DS731_06310	COG1705	Flagellar rod assembly protein muramidase FlgJ
DS731_06315	COG1256	bacterial-type flagellum assembly
DS731_06365	COG1086	Polysaccharide biosynthesis protein
DS731_06370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DS731_06375	COG1083	cytidylyl-transferase
DS731_06385	COG2089	acid synthase
DS731_06405	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_06455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS731_06460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DS731_06470	COG2226	methyltransferase
DS731_06475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DS731_06480	COG0022	dehydrogenase e1 component
DS731_06490	COG0028	Belongs to the TPP enzyme family
DS731_06500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DS731_06505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DS731_06505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DS731_06515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DS731_06520	COG2204	response regulator
DS731_06525	COG3852	Histidine kinase
DS731_06530	COG2204	response regulator
DS731_06535	COG1677	Flagellar hook-basal body complex protein FliE
DS731_06540	COG1766	The M ring may be actively involved in energy transduction
DS731_06545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DS731_06595	COG1987	bacterial-type flagellum assembly
DS731_06615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DS731_06625	COG0455	bacterial-type flagellum organization
DS731_06640	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DS731_06645	COG0643	Histidine kinase
DS731_06645	COG2198	Histidine kinase
DS731_06650	COG2201	protein-glutamate methylesterase activity
DS731_06655	COG1192	Involved in chromosome partitioning
DS731_06665	COG0835	chemotaxis
DS731_06675	COG1522	sequence-specific DNA binding
DS731_06690	COG1410	methionine synthase
DS731_06690	COG0646	methionine synthase
DS731_06715	COG0583	DNA-binding transcription factor activity
DS731_06735	COG0288	reversible hydration of carbon dioxide
DS731_06740	COG0659	secondary active sulfate transmembrane transporter activity
DS731_06745	COG4771	TonB-dependent receptor
DS731_06755	COG3590	peptidase
DS731_06765	COG2137	regulation of response to DNA damage stimulus
DS731_06770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DS731_06795	COG0745	RESPONSE REGULATOR receiver
DS731_06800	COG0642	Histidine kinase
DS731_06845	COG3630	sodium ion export across plasma membrane
DS731_06855	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DS731_06860	COG4172	Belongs to the ABC transporter superfamily
DS731_06865	COG4172	Belongs to the ABC transporter superfamily
DS731_06870	COG4171	peptide transport system, permease
DS731_06875	COG4168	peptide transport system, permease
DS731_06880	COG0747	negative chemotaxis
DS731_06885	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DS731_06890	COG1842	Phage shock protein A
DS731_06920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DS731_06930	COG0625	glutathione transferase activity
DS731_06935	COG1522	sequence-specific DNA binding
DS731_06940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS731_06980	COG0811	peptide transport
DS731_06985	COG0811	peptide transport
DS731_06990	COG0848	biopolymer transport protein
DS731_07055	COG0456	acetyltransferase
DS731_07070	COG0583	DNA-binding transcription factor activity
DS731_07075	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_07085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DS731_07090	COG2116	formate transmembrane transporter activity
DS731_07100	COG0564	pseudouridine synthase activity
DS731_07110	COG0612	Peptidase, M16
DS731_07115	COG2918	glutathione biosynthetic process
DS731_07130	COG2840	Smr protein MutS2
DS731_07135	COG2890	protein-(glutamine-N5) methyltransferase activity
DS731_07155	COG2719	SpoVR family
DS731_07165	COG2766	serine protein kinase
DS731_07175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DS731_07180	COG4771	TonB-dependent receptor
DS731_07200	COG2906	2 iron, 2 sulfur cluster binding
DS731_07205	COG0450	alkyl hydroperoxide reductase
DS731_07210	COG2814	Major facilitator Superfamily
DS731_07210	COG0477	Major facilitator Superfamily
DS731_07215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DS731_07225	COG0584	glycerophosphoryl diester phosphodiesterase
DS731_07240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DS731_07245	COG4660	Part of a membrane complex involved in electron transport
DS731_07255	COG4658	electron transport chain
DS731_07260	COG4656	Part of a membrane complex involved in electron transport
DS731_07265	COG2878	Part of a membrane complex involved in electron transport
DS731_07270	COG4657	Part of a membrane complex involved in electron transport
DS731_07290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DS731_07430	COG4974	Belongs to the 'phage' integrase family
DS731_07455	COG0629	single-stranded DNA binding
DS731_07550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DS731_07565	COG0534	Mate efflux family protein
DS731_07570	COG0556	nucleotide-excision repair
DS731_07585	COG0602	queuosine metabolic process
DS731_07595	COG0367	asparagine synthase
DS731_07615	COG4555	ABC transporter
DS731_07620	COG1668	transmembrane transport
DS731_07625	COG3273	potassium ion transport
DS731_07625	COG0471	metal ion transport
DS731_07640	COG0529	Catalyzes the synthesis of activated sulfate
DS731_07645	COG0175	sulfate reduction
DS731_07650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_07660	COG1595	DNA-templated transcription, initiation
DS731_07695	COG0714	Associated with various cellular activities
DS731_07705	COG1024	Enoyl-CoA hydratase
DS731_07705	COG1250	3-hydroxyacyl-CoA dehydrogenase
DS731_07735	COG4536	flavin adenine dinucleotide binding
DS731_07740	COG4137	Cytochrome C assembly protein
DS731_07745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DS731_07780	COG1132	(ABC) transporter
DS731_07785	COG2204	response regulator
DS731_07795	COG4753	response regulator
DS731_07795	COG2207	Transcriptional regulator
DS731_07800	COG0228	four-way junction DNA binding
DS731_07805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DS731_07810	COG0336	Belongs to the RNA methyltransferase TrmD family
DS731_07815	COG0335	large ribosomal subunit rRNA binding
DS731_07820	COG2197	response regulator
DS731_07825	COG4585	Histidine kinase
DS731_07845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DS731_07850	COG0287	Prephenate dehydrogenase
DS731_07850	COG1605	Chorismate mutase
DS731_07880	COG0077	Prephenate dehydratase
DS731_07880	COG1605	Chorismate mutase
DS731_07885	COG0745	RESPONSE REGULATOR receiver
DS731_07890	COG0023	Translation Initiation Factor
DS731_07900	COG3706	GGDEF domain
DS731_07900	COG0745	RESPONSE REGULATOR receiver
DS731_07920	COG2205	protein histidine kinase activity
DS731_07930	COG2204	response regulator
DS731_07940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DS731_07945	COG0494	nUDIX hydrolase
DS731_07950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DS731_07960	COG2255	four-way junction helicase activity
DS731_07965	COG0824	Thioesterase
DS731_07970	COG0811	peptide transport
DS731_07985	COG0823	Involved in the tonB-independent uptake of proteins
DS731_07990	COG2885	chlorophyll binding
DS731_07995	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DS731_08010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DS731_08040	COG0457	Tetratricopeptide repeat
DS731_08045	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DS731_08055	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DS731_08080	COG3706	GGDEF domain
DS731_08090	COG3008	intermembrane lipid transfer
DS731_08090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DS731_08095	COG2995	paraquat-inducible protein a
DS731_08100	COG0017	Asparaginyl-tRNA synthetase
DS731_08115	COG0189	ligase activity
DS731_08150	COG0156	8-amino-7-oxononanoate synthase activity
DS731_08155	COG1073	alpha beta
DS731_08155	COG2226	methyltransferase
DS731_08165	COG3340	Belongs to the peptidase S51 family
DS731_08175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_08180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS731_08185	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_08190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DS731_08195	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DS731_08220	COG5265	(ABC) transporter
DS731_08225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DS731_08260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DS731_08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS731_08305	COG0402	S-adenosylhomocysteine deaminase activity
DS731_08310	COG0402	S-adenosylhomocysteine deaminase activity
DS731_08320	COG4181	ATPase activity
DS731_08325	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DS731_08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_08340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_08360	COG1396	sequence-specific DNA binding
DS731_08370	COG1090	epimerase
DS731_08375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DS731_08380	COG0628	permease
DS731_08385	COG0243	molybdopterin cofactor binding
DS731_08390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DS731_08400	COG1049	propionate catabolic process, 2-methylcitrate cycle
DS731_08410	COG0745	RESPONSE REGULATOR receiver
DS731_08425	COG2350	Protein conserved in bacteria
DS731_08440	COG0135	phosphoribosylanthranilate isomerase activity
DS731_08440	COG0134	indole-3-glycerol-phosphate synthase activity
DS731_08445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS731_08450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS731_08450	COG0512	Glutamine amidotransferase of anthranilate synthase
DS731_08455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DS731_08465	COG0009	L-threonylcarbamoyladenylate synthase
DS731_08475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DS731_08480	COG1187	pseudouridine synthase activity
DS731_08490	COG0656	L-ascorbic acid biosynthetic process
DS731_08495	COG2733	membrane
DS731_08510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_08515	COG0497	DNA recombination
DS731_08520	COG2814	Major facilitator Superfamily
DS731_08520	COG0477	Major facilitator Superfamily
DS731_08540	COG1846	Transcriptional regulator
DS731_08540	COG1940	carbohydrate kinase activity
DS731_08570	COG0384	phenazine biosynthesis protein PhzF
DS731_08600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DS731_08605	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_08615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DS731_08620	COG2610	gluconate transmembrane transporter activity
DS731_08635	COG2205	protein histidine kinase activity
DS731_08635	COG2198	Histidine kinase
DS731_08635	COG0784	Response regulator, receiver
DS731_08640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DS731_08650	COG0484	heat shock protein binding
DS731_08655	COG2801	Transposase and inactivated derivatives
DS731_08660	COG2963	transposase activity
DS731_08665	COG0784	Response regulator, receiver
DS731_08665	COG3437	response regulator, receiver
DS731_08670	COG4191	Histidine kinase
DS731_08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_08680	COG3401	FG-GAP repeat protein
DS731_08700	COG3290	protein histidine kinase activity
DS731_08750	COG3706	GGDEF domain
DS731_08755	COG0583	DNA-binding transcription factor activity
DS731_08760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DS731_08765	COG2828	Protein conserved in bacteria
DS731_08770	COG2159	amidohydrolase
DS731_08825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DS731_08845	COG0745	RESPONSE REGULATOR receiver
DS731_08845	COG4566	intracellular signal transduction
DS731_08860	COG2823	Periplasmic or secreted lipoprotein
DS731_08870	COG2853	Lipoprotein
DS731_08895	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DS731_08930	COG2198	Histidine kinase
DS731_08930	COG0784	Response regulator, receiver
DS731_08930	COG5002	protein histidine kinase activity
DS731_08935	COG0784	Response regulator, receiver
DS731_08940	COG4251	negative regulation of phosphorylation
DS731_08950	COG2204	response regulator
DS731_08960	COG0583	DNA-binding transcription factor activity
DS731_08970	COG0640	Transcriptional regulator
DS731_08985	COG0583	DNA-binding transcription factor activity
DS731_09015	COG5001	Diguanylate cyclase
DS731_09015	COG3300	MHYT domain
DS731_09030	COG1022	Amp-dependent synthetase and ligase
DS731_09045	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DS731_09050	COG1074	ATP-dependent DNA helicase activity
DS731_09055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DS731_09075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DS731_09080	COG0521	Mo-molybdopterin cofactor biosynthetic process
DS731_09085	COG0315	cyclic pyranopterin monophosphate synthase activity
DS731_09090	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DS731_09095	COG0314	molybdopterin synthase activity
DS731_09110	COG1618	nucleotide phosphatase activity, acting on free nucleotides
DS731_09110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DS731_09115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DS731_09120	COG4771	TonB-dependent receptor
DS731_09155	COG5002	protein histidine kinase activity
DS731_09155	COG0784	Response regulator, receiver
DS731_09155	COG2198	Histidine kinase
DS731_09160	COG3437	response regulator, receiver
DS731_09170	COG0195	Participates in both transcription termination and antitermination
DS731_09185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DS731_09200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS731_09200	COG3153	acetyltransferase
DS731_09215	COG3706	GGDEF domain
DS731_09215	COG0745	RESPONSE REGULATOR receiver
DS731_09225	COG0450	alkyl hydroperoxide reductase
DS731_09240	COG1309	transcriptional regulator
DS731_09245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_09265	COG1032	radical SAM domain protein
DS731_09280	COG1228	amidohydrolase
DS731_09285	COG5001	Diguanylate cyclase
DS731_09285	COG3706	GGDEF domain
DS731_09285	COG4251	negative regulation of phosphorylation
DS731_09285	COG2203	Gaf domain
DS731_09295	COG1187	pseudouridine synthase activity
DS731_09350	COG0582	viral genome integration into host DNA
DS731_09385	COG4628	conserved protein (DUF2132)
DS731_09390	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS731_09390	COG1902	pentaerythritol trinitrate reductase activity
DS731_09400	COG2867	negative regulation of translational initiation
DS731_09405	COG2914	Belongs to the UPF0125 (RnfH) family
DS731_09415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS731_09425	COG0457	Tetratricopeptide repeat
DS731_09435	COG0574	Belongs to the PEP-utilizing enzyme family
DS731_09435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DS731_09455	COG2850	peptidyl-arginine hydroxylation
DS731_09465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DS731_09470	COG2915	High frequency lysogenization protein hflD homolog
DS731_09475	COG0482	sulfurtransferase activity
DS731_09480	COG1187	pseudouridine synthase activity
DS731_09490	COG1278	Cold shock
DS731_09495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DS731_09500	COG0542	response to heat
DS731_09505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DS731_09510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DS731_09515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DS731_09520	COG0492	ferredoxin-NADP+ reductase activity
DS731_09525	COG3092	negative regulation of chromosome organization
DS731_09535	COG0616	signal peptide processing
DS731_09540	COG0778	Nitroreductase
DS731_09545	COG0469	pyruvate kinase activity
DS731_09550	COG1737	Transcriptional regulator
DS731_09555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DS731_09565	COG0129	dihydroxy-acid dehydratase activity
DS731_09575	COG0800	Aldolase
DS731_09590	COG0676	glucose-6-phosphate 1-epimerase activity
DS731_09600	COG1640	4-alpha-glucanotransferase
DS731_09605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DS731_09615	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DS731_09635	COG2866	Carboxypeptidase
DS731_09640	COG1115	amino acid carrier protein
DS731_09650	COG3139	Protein of unknown function (DUF1315)
DS731_09670	COG0252	asparaginase activity
DS731_09685	COG3706	GGDEF domain
DS731_09690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DS731_09695	COG0321	lipoyl(octanoyl) transferase activity
DS731_09700	COG2921	Belongs to the UPF0250 family
DS731_09705	COG1686	Belongs to the peptidase S11 family
DS731_09710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DS731_09715	COG0772	Belongs to the SEDS family
DS731_09720	COG0768	penicillin binding
DS731_09725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DS731_09730	COG0799	negative regulation of ribosome biogenesis
DS731_09740	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DS731_09745	COG0495	leucyl-tRNA aminoacylation
DS731_09755	COG1067	ATP-dependent peptidase activity
DS731_09770	COG1534	Rna-binding protein
DS731_09775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DS731_09780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DS731_09785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DS731_09795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DS731_09855	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DS731_09890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_09890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_09900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DS731_09995	COG0756	dUTP diphosphatase activity
DS731_10105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DS731_10190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DS731_10230	COG4325	translation initiation factor activity
DS731_10235	COG1597	lipid kinase activity
DS731_10255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_10280	COG1185	polyribonucleotide nucleotidyltransferase activity
DS731_10310	COG1196	nuclear chromosome segregation
DS731_10320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DS731_10330	COG0658	competence protein
DS731_10330	COG2333	competence protein COMEC
DS731_10335	COG1132	(ABC) transporter
DS731_10340	COG1663	tetraacyldisaccharide 4'-kinase activity
DS731_10380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DS731_10385	COG0435	Glutathione S-transferase
DS731_10415	COG2009	succinate dehydrogenase
DS731_10420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DS731_10425	COG1053	succinate dehydrogenase
DS731_10430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DS731_10435	COG0567	Dehydrogenase, E1 component
DS731_10440	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS731_10455	COG0840	transmembrane signaling receptor activity
DS731_10480	COG0366	Alpha amylase catalytic
DS731_10500	COG0366	Alpha amylase catalytic
DS731_10530	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_10535	COG2267	carboxylic ester hydrolase activity
DS731_10555	COG0616	signal peptide processing
DS731_10570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DS731_10575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DS731_10580	COG0386	Belongs to the glutathione peroxidase family
DS731_10585	COG2084	Dehydrogenase
DS731_10600	COG1960	acyl-CoA dehydrogenase activity
DS731_10605	COG1024	Enoyl-CoA hydratase
DS731_10615	COG2226	methyltransferase
DS731_10620	COG3083	sulfuric ester hydrolase activity
DS731_10625	COG3082	Protein of unknown function (DUF1414)
DS731_10630	COG3081	Nucleoid-associated protein
DS731_10660	COG3275	phosphorelay sensor kinase activity
DS731_10665	COG3279	Response regulator of the LytR AlgR family
DS731_10670	COG0205	6-phosphofructokinase activity
DS731_10680	COG0697	spore germination
DS731_10685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_10685	COG2205	protein histidine kinase activity
DS731_10705	COG0513	Belongs to the DEAD box helicase family
DS731_10715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DS731_10720	COG0583	DNA-binding transcription factor activity
DS731_10745	COG1760	l-serine dehydratase
DS731_10765	COG1322	Protein conserved in bacteria
DS731_10775	COG3547	Transposase (IS116 IS110 IS902 family)
DS731_10870	COG1404	Belongs to the peptidase S8 family
DS731_10880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DS731_10885	COG0022	dehydrogenase e1 component
DS731_10895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DS731_10900	COG0515	serine threonine protein kinase
DS731_10905	COG1946	Acyl-CoA thioesterase
DS731_10910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DS731_10925	COG2715	membrane protein required for spore maturation
DS731_10935	COG1956	GAF domain-containing protein
DS731_10950	COG0793	Belongs to the peptidase S41A family
DS731_10955	COG0733	neurotransmitter:sodium symporter activity
DS731_10965	COG0308	aminopeptidase N
DS731_11000	COG0167	dihydroorotate dehydrogenase activity
DS731_11025	COG3130	regulation of translation
DS731_11030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DS731_11040	COG0415	Belongs to the DNA photolyase family
DS731_11045	COG0415	Belongs to the DNA photolyase family
DS731_11050	COG0415	Belongs to the DNA photolyase family
DS731_11055	COG3046	protein related to deoxyribodipyrimidine photolyase
DS731_11090	COG4974	Belongs to the 'phage' integrase family
DS731_11115	COG4946	Tricorn protease homolog
DS731_11115	COG0823	Involved in the tonB-independent uptake of proteins
DS731_11115	COG1506	peptidase
DS731_11140	COG0589	response to stress
DS731_11145	COG0069	glutamate synthase activity
DS731_11150	COG0475	glutathione-regulated potassium exporter activity
DS731_11150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DS731_11160	COG2193	ferroxidase activity
DS731_11170	COG3278	Belongs to the heme-copper respiratory oxidase family
DS731_11185	COG2010	Cytochrome c
DS731_11195	COG2217	Heavy metal translocating P-type atpase
DS731_11210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DS731_11215	COG0589	response to stress
DS731_11220	COG0037	tRNA processing
DS731_11225	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS731_11245	COG1280	lysine exporter protein (LysE YggA)
DS731_11250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DS731_11255	COG2897	thiosulfate sulfurtransferase activity
DS731_11280	COG0322	excinuclease ABC activity
DS731_11285	COG2197	response regulator
DS731_11290	COG1741	Belongs to the pirin family
DS731_11295	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DS731_11315	COG0670	Belongs to the BI1 family
DS731_11335	COG2920	part of a sulfur-relay system
DS731_11350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DS731_11355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DS731_11360	COG1674	ftsk spoiiie
DS731_11360	COG0531	amino acid
DS731_11370	COG0686	Belongs to the AlaDH PNT family
DS731_11375	COG0284	orotidine-5'-phosphate decarboxylase activity
DS731_11380	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DS731_11385	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DS731_11395	COG0776	regulation of translation
DS731_11400	COG0539	negative regulation of cytoplasmic translation
DS731_11405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DS731_11410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DS731_11430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS731_11440	COG0633	Ferredoxin
DS731_11450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DS731_11470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DS731_11475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DS731_11485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DS731_11495	COG4783	chaperone-mediated protein folding
DS731_11500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS731_11505	COG1393	Belongs to the ArsC family
DS731_11520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DS731_11535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DS731_11545	COG1960	acyl-CoA dehydrogenase activity
DS731_11575	COG1215	transferase activity, transferring glycosyl groups
DS731_11580	COG0366	Alpha amylase catalytic
DS731_11585	COG0303	'Molybdopterin
DS731_11590	COG0534	Mate efflux family protein
DS731_11605	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DS731_11610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS731_11620	COG0405	Gamma-glutamyltransferase
DS731_11625	COG1024	Enoyl-CoA hydratase
DS731_11660	COG2873	o-acetylhomoserine
DS731_11720	COG0596	Alpha beta hydrolase
DS731_11730	COG0716	FMN binding
DS731_11740	COG0735	belongs to the Fur family
DS731_11750	COG1984	allophanate hydrolase subunit 2
DS731_11755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DS731_11765	COG2996	Protein conserved in bacteria
DS731_11770	COG1765	OsmC-like protein
DS731_11780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_11800	COG0436	Aminotransferase
DS731_11810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DS731_11820	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DS731_11825	COG0251	oxidation-reduction process
DS731_11830	COG2010	Cytochrome c
DS731_11835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS731_11850	COG3384	dioxygenase
DS731_11860	COG0084	hydrolase, TatD family'
DS731_11865	COG0470	DNA polymerase III
DS731_11875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DS731_11880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS731_11885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DS731_11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS731_11905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DS731_11910	COG0416	fatty acid biosynthetic process
DS731_11920	COG1399	metal-binding, possibly nucleic acid-binding protein
DS731_11930	COG0546	phosphoglycolate phosphatase activity
DS731_11935	COG0564	pseudouridine synthase activity
DS731_11945	COG1530	ribonuclease E activity
DS731_11955	COG3122	Protein conserved in bacteria
DS731_11960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DS731_11965	COG3724	N-succinylarginine dihydrolase activity
DS731_11970	COG2373	Large extracellular alpha-helical protein
DS731_11970	COG1388	LysM domain
DS731_11970	COG4932	domain protein
DS731_11975	COG1301	dicarboxylic acid transport
DS731_11980	COG4591	ABC-type transport system involved in lipoprotein release permease component
DS731_11985	COG1136	(ABC) transporter
DS731_12020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DS731_12025	COG0328	RNA-DNA hybrid ribonuclease activity
DS731_12030	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_12040	COG1566	PFAM secretion protein HlyD family protein
DS731_12080	COG1643	Atp-dependent helicase
DS731_12085	COG2963	transposase activity
DS731_12090	COG2801	Transposase and inactivated derivatives
DS731_12100	COG0745	RESPONSE REGULATOR receiver
DS731_12100	COG3706	GGDEF domain
DS731_12125	COG2925	Exonuclease
DS731_12135	COG3706	GGDEF domain
DS731_12155	COG0789	Transcriptional regulator
DS731_12160	COG1960	acyl-CoA dehydrogenase activity
DS731_12165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DS731_12170	COG1024	Enoyl-CoA hydratase
DS731_12215	COG1639	'signal transduction protein
DS731_12230	COG2166	iron-sulfur cluster assembly
DS731_12255	COG4251	negative regulation of phosphorylation
DS731_12265	COG0708	Exodeoxyribonuclease III
DS731_12280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DS731_12285	COG4591	ABC-type transport system involved in lipoprotein release permease component
DS731_12295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DS731_12305	COG0471	metal ion transport
DS731_12310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DS731_12325	COG0072	phenylalanine-tRNA ligase activity
DS731_12325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS731_12370	COG4681	YaeQ
DS731_12390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS731_12395	COG0154	amidase activity
DS731_12405	COG0730	response to heat
DS731_12410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DS731_12425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DS731_12430	COG2233	PERMEase
DS731_12445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DS731_12450	COG2252	PERMEase
DS731_12460	COG4191	Histidine kinase
DS731_12460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_12470	COG1309	transcriptional regulator
DS731_12480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DS731_12495	COG2351	hydroxyisourate hydrolase activity
DS731_12500	COG0402	S-adenosylhomocysteine deaminase activity
DS731_12520	COG0667	Aldo Keto reductase
DS731_12535	COG1501	Belongs to the glycosyl hydrolase 31 family
DS731_12555	COG2207	Transcriptional regulator
DS731_12615	COG1484	DNA-dependent DNA replication
DS731_12670	COG1846	Transcriptional regulator
DS731_12690	COG1522	sequence-specific DNA binding
DS731_12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS731_12700	COG4251	negative regulation of phosphorylation
DS731_12705	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_12710	COG2860	membrane
DS731_12720	COG3665	Urea carboxylase-associated protein
DS731_12750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS731_12780	COG1473	amidohydrolase
DS731_12795	COG0668	transmembrane transport
DS731_12800	COG2814	Major facilitator Superfamily
DS731_12810	COG1228	amidohydrolase
DS731_12835	COG0582	viral genome integration into host DNA
DS731_12865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DS731_12870	COG0601	transmembrane transport
DS731_12880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS731_12900	COG0473	3-isopropylmalate dehydrogenase activity
DS731_12905	COG1012	belongs to the aldehyde dehydrogenase family
DS731_12910	COG1881	PFAM PEBP family protein
DS731_12950	COG2308	Evidence 4 Homologs of previously reported genes of
DS731_12960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DS731_12970	COG4771	TonB-dependent receptor
DS731_12985	COG4771	TonB-dependent receptor
DS731_12995	COG1595	DNA-templated transcription, initiation
DS731_13000	COG0405	Gamma-glutamyltransferase
DS731_13005	COG0405	Gamma-glutamyltransferase
DS731_13010	COG0643	Histidine kinase
DS731_13010	COG2198	Histidine kinase
DS731_13025	COG1136	(ABC) transporter
DS731_13030	COG3045	CreA protein
DS731_13040	COG1280	lysine exporter protein (LysE YggA)
DS731_13045	COG1393	Belongs to the ArsC family
DS731_13075	COG2988	succinylglutamate desuccinylase activity
DS731_13090	COG0583	DNA-binding transcription factor activity
DS731_13100	COG0058	SHG alpha-glucan phosphorylase activity
DS731_13105	COG0033	Phosphoglucomutase
DS731_13110	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DS731_13115	COG0714	Associated with various cellular activities
DS731_13140	COG2363	Small membrane protein
DS731_13150	COG0583	DNA-binding transcription factor activity
DS731_13170	COG0784	Response regulator, receiver
DS731_13170	COG3437	response regulator, receiver
DS731_13175	COG2890	protein-(glutamine-N5) methyltransferase activity
DS731_13185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DS731_13190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DS731_13195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DS731_13205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DS731_13230	COG0012	GTP binding
DS731_13235	COG2031	fatty acid transporter
DS731_13260	COG1115	amino acid carrier protein
DS731_13270	COG1309	transcriptional regulator
DS731_13280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_13290	COG1702	phosphate starvation-inducible protein PhoH
DS731_13300	COG4535	Mg2 and Co2 transporter CorC
DS731_13305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DS731_13330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS731_13335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DS731_13340	COG0505	Belongs to the CarA family
DS731_13345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DS731_13365	COG3909	cytochrome
DS731_13370	COG1280	lysine exporter protein (LysE YggA)
DS731_13415	COG0471	metal ion transport
DS731_13430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS731_13430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS731_13440	COG2226	methyltransferase
DS731_13445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS731_13450	COG1388	LysM domain
DS731_13450	COG0741	lytic transglycosylase activity
DS731_13465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DS731_13470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS731_13480	COG1404	Belongs to the peptidase S8 family
DS731_13500	COG1785	Belongs to the alkaline phosphatase family
DS731_13505	COG1785	Belongs to the alkaline phosphatase family
DS731_13515	COG1585	Membrane protein implicated in regulation of membrane protease activity
DS731_13520	COG2268	Band 7 protein
DS731_13525	COG4585	Histidine kinase
DS731_13565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DS731_13570	COG1286	toxin biosynthetic process
DS731_13575	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DS731_13580	COG0285	dihydrofolate synthase activity
DS731_13590	COG0101	tRNA pseudouridine synthase activity
DS731_13605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS731_13615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS731_13615	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DS731_13645	COG3101	peptidyl-lysine hydroxylation
DS731_13665	COG1902	pentaerythritol trinitrate reductase activity
DS731_13665	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS731_13685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS731_13690	COG1309	transcriptional regulator
DS731_13695	COG4399	Belongs to the UPF0754 family
DS731_13730	COG2186	Transcriptional regulator
DS731_13740	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DS731_13745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS731_13750	COG2983	Belongs to the UPF0260 family
DS731_13755	COG0179	Fumarylacetoacetate (FAA) hydrolase
DS731_13770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DS731_13775	COG0318	PFAM AMP-dependent synthetase and ligase
DS731_13780	COG2267	carboxylic ester hydrolase activity
DS731_13795	COG1214	PFAM Peptidase M22, glycoprotease
DS731_13800	COG1199	ATP-dependent helicase activity
DS731_13820	COG0840	transmembrane signaling receptor activity
DS731_13835	COG0640	Transcriptional regulator
DS731_13845	COG0798	PFAM Bile acid sodium symporter
DS731_13860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DS731_13865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DS731_13870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DS731_13875	COG0131	Imidazoleglycerol-phosphate dehydratase
DS731_13875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DS731_13880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DS731_13905	COG0681	Belongs to the peptidase S26 family
DS731_13910	COG0071	Belongs to the small heat shock protein (HSP20) family
DS731_13925	COG0702	epimerase
DS731_13945	COG0326	Molecular chaperone. Has ATPase activity
DS731_13950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DS731_13970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DS731_13975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DS731_13985	COG3220	belongs to the UPF0276 family
DS731_14030	COG1183	phosphatidylcholine synthase activity
DS731_14050	COG0542	response to heat
DS731_14060	COG0564	pseudouridine synthase activity
DS731_14065	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_14070	COG3806	Anti-sigma factor
DS731_14075	COG1595	DNA-templated transcription, initiation
DS731_14090	COG4221	oxidoreductase activity
DS731_14105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DS731_14115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DS731_14125	COG0142	geranyltranstransferase activity
DS731_14135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DS731_14140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DS731_14150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DS731_14165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS731_14165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS731_14180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS731_14185	COG0488	(ABC) transporter
DS731_14195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DS731_14205	COG0560	Phosphoserine phosphatase
DS731_14215	COG0084	hydrolase, TatD family'
DS731_14225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DS731_14230	COG0571	ribonuclease III activity
DS731_14235	COG0681	Belongs to the peptidase S26 family
DS731_14260	COG1595	DNA-templated transcription, initiation
DS731_14265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DS731_14280	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DS731_14290	COG1047	Peptidyl-prolyl cis-trans
DS731_14355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DS731_14360	COG1047	Peptidyl-prolyl cis-trans
DS731_14370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DS731_14375	COG0196	riboflavin kinase activity
DS731_14380	COG0728	peptidoglycan biosynthetic process
DS731_14385	COG0268	Binds directly to 16S ribosomal RNA
DS731_14420	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DS731_14430	COG1566	PFAM secretion protein HlyD family protein
DS731_14450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS731_14455	COG0776	regulation of translation
DS731_14460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DS731_14470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DS731_14475	COG0740	serine-type endopeptidase activity
DS731_14480	COG0544	peptidyl-prolyl cis-trans isomerase activity
DS731_14530	COG1131	(ABC) transporter
DS731_14535	COG1720	tRNA m6t6A37 methyltransferase activity
DS731_14550	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DS731_14555	COG0123	including yeast histone deacetylase and acetoin utilization protein
DS731_14560	COG0840	transmembrane signaling receptor activity
DS731_14565	COG0604	alcohol dehydrogenase
DS731_14570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DS731_14575	COG1064	alcohol dehydrogenase
DS731_14590	COG0517	IMP dehydrogenase activity
DS731_14590	COG0516	GMP reductase activity
DS731_14595	COG1570	exodeoxyribonuclease VII activity
DS731_14610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_14615	COG2976	Protein conserved in bacteria
DS731_14640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DS731_14650	COG0339	signal peptide processing
DS731_14660	COG2166	iron-sulfur cluster assembly
DS731_14665	COG2151	metal-sulfur cluster biosynthetic enzyme
DS731_14675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DS731_14680	COG0719	Fe-S assembly protein
DS731_14685	COG0396	ATPase activity
DS731_14690	COG0719	Fe-S assembly protein
DS731_14695	COG1104	cysteine desulfurase activity
DS731_14700	COG1959	2 iron, 2 sulfur cluster binding
DS731_14710	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DS731_14715	COG0483	inositol monophosphate 1-phosphatase activity
DS731_14720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS731_14725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS731_14730	COG1862	Preprotein translocase
DS731_14735	COG0343	queuine tRNA-ribosyltransferase activity
DS731_14755	COG1842	Phage shock protein A
DS731_14760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DS731_14780	COG0754	glutathionylspermidine amidase activity
DS731_14795	COG1785	Belongs to the alkaline phosphatase family
DS731_14850	COG1045	serine acetyltransferase
DS731_14855	COG1215	transferase activity, transferring glycosyl groups
DS731_14865	COG0726	polysaccharide deacetylase
DS731_14870	COG0438	transferase activity, transferring glycosyl groups
DS731_14875	COG0438	transferase activity, transferring glycosyl groups
DS731_14890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DS731_14905	COG0489	protein tyrosine kinase activity
DS731_14915	COG3267	Type II secretory pathway component ExeA
DS731_14915	COG3409	Peptidoglycan-binding domain 1 protein
DS731_14920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DS731_14920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DS731_14925	COG2827	Endonuclease containing a URI domain
DS731_14945	COG1560	Kdo2-lipid A biosynthetic process
DS731_14980	COG3300	MHYT domain
DS731_14980	COG5001	Diguanylate cyclase
DS731_14985	COG1435	thymidine kinase activity
DS731_14990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_15000	COG1609	Transcriptional regulator
DS731_15010	COG0583	DNA-binding transcription factor activity
DS731_15015	COG1595	DNA-templated transcription, initiation
DS731_15025	COG1473	amidohydrolase
DS731_15030	COG1473	amidohydrolase
DS731_15040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DS731_15075	COG2894	cell division
DS731_15080	COG0850	regulation of cytokinetic process
DS731_15110	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DS731_15120	COG0535	radical SAM domain protein
DS731_15150	COG1971	Probably functions as a manganese efflux pump
DS731_15170	COG4269	membrane
DS731_15195	COG0604	alcohol dehydrogenase
DS731_15200	COG1309	transcriptional regulator
DS731_15220	COG0668	transmembrane transport
DS731_15225	COG0668	transmembrane transport
DS731_15230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_15230	COG4191	Histidine kinase
DS731_15235	COG0628	permease
DS731_15240	COG0513	Belongs to the DEAD box helicase family
DS731_15250	COG0210	DNA helicase
DS731_15255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS731_15315	COG0583	DNA-binding transcription factor activity
DS731_15330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_15335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_15340	COG0006	proline dipeptidase activity
DS731_15345	COG3079	Belongs to the UPF0149 family
DS731_15355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS731_15370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DS731_15375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DS731_15380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS731_15395	COG2963	transposase activity
DS731_15400	COG2801	Transposase and inactivated derivatives
DS731_15420	COG3313	Fe-S protein
DS731_15440	COG0583	DNA-binding transcription factor activity
DS731_15445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS731_15450	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS731_15455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DS731_15460	COG2186	Transcriptional regulator
DS731_15470	COG3023	N-Acetylmuramoyl-L-alanine amidase
DS731_15475	COG3577	Aspartyl protease
DS731_15485	COG4969	Belongs to the N-Me-Phe pilin family
DS731_15490	COG1459	type II secretion system
DS731_15500	COG0237	dephospho-CoA kinase activity
DS731_15505	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DS731_15515	COG2988	succinylglutamate desuccinylase activity
DS731_15520	COG0840	transmembrane signaling receptor activity
DS731_15540	COG2198	Histidine kinase
DS731_15540	COG0643	Histidine kinase
DS731_15545	COG0745	RESPONSE REGULATOR receiver
DS731_15550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DS731_15560	COG2201	protein-glutamate methylesterase activity
DS731_15565	COG0835	chemotaxis
DS731_15570	COG0840	transmembrane signaling receptor activity
DS731_15570	COG3290	protein histidine kinase activity
DS731_15575	COG0494	nUDIX hydrolase
DS731_15585	COG1196	nuclear chromosome segregation
DS731_15585	COG0739	heme binding
DS731_15585	COG0741	lytic transglycosylase activity
DS731_15590	COG2199	diguanylate cyclase activity
DS731_15590	COG2203	Gaf domain
DS731_15595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DS731_15605	COG0849	cell division
DS731_15610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DS731_15615	COG1181	Belongs to the D-alanine--D-alanine ligase family
DS731_15620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DS731_15630	COG0772	Belongs to the SEDS family
DS731_15635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DS731_15645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DS731_15650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DS731_15655	COG0768	penicillin binding
DS731_15660	COG3116	cell division
DS731_15670	COG2001	Belongs to the MraZ family
DS731_15675	COG4677	pectinesterase activity
DS731_15690	COG1119	ATPase activity
DS731_15715	COG3263	regulation of cellular component size
DS731_15720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS731_15730	COG4319	ketosteroid isomerase
DS731_15750	COG3706	GGDEF domain
DS731_15755	COG2204	response regulator
DS731_15760	COG2198	Histidine kinase
DS731_15760	COG0784	Response regulator, receiver
DS731_15760	COG5002	protein histidine kinase activity
DS731_15780	COG0668	transmembrane transport
DS731_15790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DS731_15810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DS731_15835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DS731_15840	COG0762	integral membrane protein
DS731_15855	COG2130	NADP-dependent
DS731_15875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DS731_15900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DS731_15920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DS731_15955	COG4221	oxidoreductase activity
DS731_15960	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DS731_15970	COG2205	protein histidine kinase activity
DS731_16010	COG1748	Saccharopine dehydrogenase
DS731_16025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DS731_16030	COG3107	peptidoglycan biosynthetic process
DS731_16035	COG0792	nuclease activity
DS731_16075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DS731_16080	COG0372	Belongs to the citrate synthase family
DS731_16085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DS731_16115	COG5002	protein histidine kinase activity
DS731_16115	COG0784	Response regulator, receiver
DS731_16115	COG2198	Histidine kinase
DS731_16120	COG0070	glutamate synthase
DS731_16120	COG0067	glutamate synthase
DS731_16120	COG0069	glutamate synthase activity
DS731_16125	COG0493	'glutamate synthase
DS731_16135	COG3693	PFAM glycoside hydrolase, family 10
DS731_16150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DS731_16155	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DS731_16175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DS731_16180	COG0741	lytic transglycosylase activity
DS731_16180	COG1196	nuclear chromosome segregation
DS731_16180	COG0739	heme binding
DS731_16190	COG0625	glutathione transferase activity
DS731_16200	COG2223	nitrite transmembrane transporter activity
DS731_16205	COG2815	serine threonine protein kinase
DS731_16205	COG0515	serine threonine protein kinase
DS731_16235	COG1914	H( )-stimulated, divalent metal cation uptake system
DS731_16240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DS731_16255	COG0174	glutamine synthetase
DS731_16265	COG3852	Histidine kinase
DS731_16270	COG2204	response regulator
DS731_16275	COG3437	response regulator, receiver
DS731_16280	COG0204	Acyl-transferase
DS731_16305	COG2205	protein histidine kinase activity
DS731_16305	COG3437	response regulator, receiver
DS731_16305	COG3850	Histidine kinase
DS731_16305	COG4999	Histidine kinase
DS731_16310	COG0525	valine-tRNA ligase activity
DS731_16315	COG2927	DNA polymerase III (CHI subunit)
DS731_16320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DS731_16325	COG0795	lipopolysaccharide-transporting ATPase activity
DS731_16330	COG0795	lipopolysaccharide-transporting ATPase activity
DS731_16350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DS731_16390	COG2801	Transposase and inactivated derivatives
DS731_16420	COG1971	Probably functions as a manganese efflux pump
DS731_16475	COG2936	dipeptidyl-peptidase activity
DS731_16500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DS731_16530	COG3250	beta-galactosidase activity
DS731_16565	COG1472	Belongs to the glycosyl hydrolase 3 family
DS731_16570	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_16575	COG3661	Belongs to the glycosyl hydrolase 67 family
DS731_16580	COG0477	Major facilitator Superfamily
DS731_16590	COG2205	protein histidine kinase activity
DS731_16590	COG0784	Response regulator, receiver
DS731_16595	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DS731_16600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DS731_16605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DS731_16610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DS731_16655	COG1538	Outer membrane efflux protein
DS731_16665	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_16685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS731_16705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DS731_16795	COG1609	Transcriptional regulator
DS731_16820	COG0702	epimerase
DS731_16825	COG2267	carboxylic ester hydrolase activity
DS731_16850	COG1609	Transcriptional regulator
DS731_16860	COG3264	Mechanosensitive ion channel
DS731_16860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DS731_16870	COG1024	Enoyl-CoA hydratase
DS731_16875	COG1012	belongs to the aldehyde dehydrogenase family
DS731_16880	COG2271	Major facilitator Superfamily
DS731_16965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DS731_16970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS731_16975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS731_16980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS731_17005	COG4206	TonB-dependent receptor
DS731_17030	COG0583	DNA-binding transcription factor activity
DS731_17045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS731_17050	COG3659	wide pore channel activity
DS731_17060	COG0738	Major facilitator superfamily
DS731_17120	COG0842	Transport permease protein
DS731_17125	COG0842	Transport permease protein
DS731_17130	COG1131	(ABC) transporter
DS731_17145	COG0277	FAD linked oxidase domain protein
DS731_17150	COG0513	Belongs to the DEAD box helicase family
DS731_17155	COG1278	Cold shock
DS731_17165	COG5001	Diguanylate cyclase
DS731_17165	COG3300	MHYT domain
DS731_17180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS731_17205	COG1757	Na H antiporter
DS731_17215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DS731_17225	COG1845	cytochrome c oxidase, subunit III
DS731_17255	COG1902	pentaerythritol trinitrate reductase activity
DS731_17260	COG0657	acetylesterase activity
DS731_17260	COG2755	lipolytic protein G-D-S-L family
DS731_17265	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DS731_17280	COG3568	Endonuclease Exonuclease Phosphatase
DS731_17285	COG0583	DNA-binding transcription factor activity
DS731_17300	COG0730	response to heat
DS731_17310	COG0840	transmembrane signaling receptor activity
DS731_17315	COG0745	RESPONSE REGULATOR receiver
DS731_17320	COG0643	Histidine kinase
DS731_17320	COG2198	Histidine kinase
DS731_17325	COG0835	chemotaxis
DS731_17340	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DS731_17360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_17360	COG4191	Histidine kinase
DS731_17365	COG3706	GGDEF domain
DS731_17370	COG0417	DNA replication proofreading
DS731_17430	COG3300	MHYT domain
DS731_17430	COG5001	Diguanylate cyclase
DS731_17435	COG4191	Histidine kinase
DS731_17440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS731_17450	COG3300	MHYT domain
DS731_17450	COG5001	Diguanylate cyclase
DS731_17470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS731_17490	COG1983	PspC domain protein
DS731_17495	COG1842	Phage shock protein A
DS731_17505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS731_17515	COG2205	protein histidine kinase activity
DS731_17520	COG0745	RESPONSE REGULATOR receiver
DS731_17530	COG2409	Drug exporters of the RND superfamily
DS731_17545	COG1506	peptidase
DS731_17545	COG4946	Tricorn protease homolog
DS731_17545	COG0823	Involved in the tonB-independent uptake of proteins
DS731_17575	COG3547	Transposase (IS116 IS110 IS902 family)
DS731_17580	COG1874	Beta-galactosidase
DS731_17620	COG0204	Acyl-transferase
DS731_17625	COG0204	Acyl-transferase
DS731_17630	COG0668	transmembrane transport
DS731_17645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS731_17650	COG0733	neurotransmitter:sodium symporter activity
DS731_17665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DS731_17670	COG0783	Belongs to the Dps family
DS731_17685	COG0716	FMN binding
DS731_17695	COG0848	biopolymer transport protein
DS731_17710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DS731_17730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DS731_17735	COG0702	epimerase
DS731_17750	COG5001	Diguanylate cyclase
DS731_17750	COG5002	protein histidine kinase activity
DS731_17765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DS731_17775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS731_17795	COG1477	protein flavinylation
DS731_17800	COG2871	sodium ion transport
DS731_17805	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DS731_17810	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DS731_17815	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DS731_17820	COG1805	sodium ion transport
DS731_17830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DS731_17835	COG0545	Peptidyl-prolyl cis-trans isomerase
DS731_17840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DS731_17845	COG2801	Transposase and inactivated derivatives
DS731_17850	COG2963	transposase activity
DS731_17880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS731_17885	COG0039	L-malate dehydrogenase activity
DS731_17890	COG1438	arginine binding
DS731_17895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_17905	COG1538	Outer membrane efflux protein
DS731_17930	COG0572	uridine kinase
DS731_17935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DS731_17950	COG1192	Involved in chromosome partitioning
DS731_17955	COG2999	glutathione oxidoreductase activity
DS731_17960	COG3706	GGDEF domain
DS731_17970	COG5001	Diguanylate cyclase
DS731_17970	COG4251	negative regulation of phosphorylation
DS731_17970	COG3706	GGDEF domain
DS731_17970	COG2203	Gaf domain
DS731_17985	COG0517	IMP dehydrogenase activity
DS731_17985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DS731_17990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_18000	COG0784	Response regulator, receiver
DS731_18000	COG2205	protein histidine kinase activity
DS731_18000	COG2198	Histidine kinase
DS731_18010	COG0189	ligase activity
DS731_18020	COG0189	ligase activity
DS731_18020	COG4067	protein conserved in archaea
DS731_18030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DS731_18040	COG1283	sodium-dependent phosphate transmembrane transporter activity
DS731_18045	COG0667	Aldo Keto reductase
DS731_18060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DS731_18065	COG0049	tRNA binding
DS731_18070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DS731_18075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DS731_18080	COG0085	RNA polymerase activity
DS731_18085	COG0222	ribosome binding
DS731_18090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DS731_18095	COG0081	regulation of translation
DS731_18100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DS731_18105	COG0250	Participates in transcription elongation, termination and antitermination
DS731_18110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DS731_18120	COG1132	(ABC) transporter
DS731_18125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DS731_18130	COG0513	Belongs to the DEAD box helicase family
DS731_18140	COG0418	dihydroorotase activity
DS731_18150	COG3040	lipid binding
DS731_18155	COG4989	oxidoreductase activity
DS731_18160	COG0346	lactoylglutathione lyase activity
DS731_18165	COG1940	carbohydrate kinase activity
DS731_18185	COG0302	gtp cyclohydrolase
DS731_18190	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_18195	COG2957	Belongs to the agmatine deiminase family
DS731_18200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS731_18215	COG1201	RNA secondary structure unwinding
DS731_18225	COG1793	dna ligase
DS731_18230	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DS731_18250	COG2234	aminopeptidase activity
DS731_18265	COG1522	sequence-specific DNA binding
DS731_18275	COG0436	Aminotransferase
DS731_18280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_18295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DS731_18305	COG2971	BadF BadG BcrA BcrD
DS731_18310	COG1609	Transcriptional regulator
DS731_18325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_18330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DS731_18335	COG3876	Protein conserved in bacteria
DS731_18340	COG1737	Transcriptional regulator
DS731_18405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_18410	COG1757	Na H antiporter
DS731_18425	COG1012	belongs to the aldehyde dehydrogenase family
DS731_18435	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DS731_18445	COG3118	belongs to the thioredoxin family
DS731_18455	COG2133	pyrroloquinoline quinone binding
DS731_18460	COG0783	Belongs to the Dps family
DS731_18475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DS731_18490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DS731_18495	COG2205	protein histidine kinase activity
DS731_18495	COG0784	Response regulator, receiver
DS731_18500	COG1473	amidohydrolase
DS731_18505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DS731_18510	COG3118	belongs to the thioredoxin family
DS731_18515	COG0513	Belongs to the DEAD box helicase family
DS731_18520	COG0248	Ppx GppA phosphatase
DS731_18530	COG3706	GGDEF domain
DS731_18535	COG0084	hydrolase, TatD family'
DS731_18545	COG0805	protein transport
DS731_18550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS731_18570	COG0028	Belongs to the TPP enzyme family
DS731_18575	COG3085	chromosome segregation
DS731_18585	COG0457	Tetratricopeptide repeat
DS731_18595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DS731_18610	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DS731_18630	COG0584	glycerophosphoryl diester phosphodiesterase
DS731_18640	COG2861	carbohydrate metabolic process
DS731_18645	COG4942	peptidase
DS731_18655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DS731_18665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DS731_18675	COG0577	efflux transmembrane transporter activity
DS731_18675	COG1136	(ABC) transporter
DS731_18680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_18685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DS731_18690	COG2267	carboxylic ester hydrolase activity
DS731_18695	COG2205	protein histidine kinase activity
DS731_18700	COG0745	RESPONSE REGULATOR receiver
DS731_18705	COG1803	Methylglyoxal synthase
DS731_18720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DS731_18725	COG0137	argininosuccinate synthase activity
DS731_18735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DS731_18735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DS731_18750	COG2808	Putative FMN-binding domain
DS731_18770	COG0281	malic enzyme
DS731_18775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DS731_18780	COG0849	cell division
DS731_18810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DS731_18820	COG1671	Belongs to the UPF0178 family
DS731_18825	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DS731_18845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DS731_18850	COG0180	Tryptophanyl-tRNA synthetase
DS731_18865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DS731_18870	COG3138	arginine N-succinyltransferase
DS731_18875	COG1012	belongs to the aldehyde dehydrogenase family
DS731_18905	COG2755	lipolytic protein G-D-S-L family
DS731_18925	COG3254	rhamnose metabolic process
DS731_18950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DS731_18960	COG0823	Involved in the tonB-independent uptake of proteins
DS731_18965	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_18975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS731_19005	COG2056	Na+-H+ antiporter family
DS731_19010	COG1228	amidohydrolase
DS731_19015	COG2986	histidine ammonia-lyase
DS731_19025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DS731_19030	COG0784	Response regulator, receiver
DS731_19030	COG5002	protein histidine kinase activity
DS731_19030	COG2205	protein histidine kinase activity
DS731_19040	COG0540	Belongs to the ATCase OTCase family
DS731_19055	COG2837	iron assimilation
DS731_19060	COG0405	Gamma-glutamyltransferase
DS731_19065	COG0753	catalase activity
DS731_19080	COG0004	ammonium transporteR
DS731_19085	COG0347	Belongs to the P(II) protein family
DS731_19095	COG2354	Protein conserved in bacteria
DS731_19105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DS731_19115	COG3243	poly(R)-hydroxyalkanoic acid synthase
DS731_19125	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DS731_19145	COG2951	lytic endotransglycosylase activity
DS731_19150	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_19155	COG1643	Atp-dependent helicase
DS731_19160	COG3706	GGDEF domain
DS731_19170	COG0788	formyltetrahydrofolate deformylase activity
DS731_19175	COG0339	signal peptide processing
DS731_19195	COG1519	Transferase
DS731_19200	COG0859	PFAM glycosyl transferase family 9
DS731_19205	COG0297	glycogen (starch) synthase activity
DS731_19210	COG0456	acetyltransferase
DS731_19210	COG0454	-acetyltransferase
DS731_19230	COG0579	oxidoreductase
DS731_19255	COG2211	Major facilitator Superfamily
DS731_19265	COG0673	inositol 2-dehydrogenase activity
DS731_19270	COG1609	Transcriptional regulator
DS731_19300	COG0477	Major facilitator Superfamily
DS731_19305	COG2207	Transcriptional regulator
DS731_19305	COG1609	Transcriptional regulator
DS731_19310	COG1070	Carbohydrate kinase
DS731_19315	COG2115	Belongs to the xylose isomerase family
DS731_19320	COG0436	Aminotransferase
DS731_19330	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DS731_19350	COG2198	Histidine kinase
DS731_19350	COG0643	Histidine kinase
DS731_19355	COG0745	RESPONSE REGULATOR receiver
DS731_19365	COG4946	Tricorn protease homolog
DS731_19365	COG0793	Belongs to the peptidase S41A family
DS731_19385	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DS731_19395	COG2267	carboxylic ester hydrolase activity
DS731_19400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DS731_19410	COG0297	glycogen (starch) synthase activity
DS731_19415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_19415	COG4191	Histidine kinase
DS731_19420	COG0745	RESPONSE REGULATOR receiver
DS731_19425	COG0312	modulator of DNA gyrase
DS731_19430	COG3028	Belongs to the UPF0307 family
DS731_19445	COG0312	modulator of DNA gyrase
DS731_19450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS731_19460	COG1530	ribonuclease E activity
DS731_19465	COG0424	maF-like protein
DS731_19470	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DS731_19475	COG1792	Involved in formation and maintenance of cell shape
DS731_19480	COG1077	Cell shape determining protein MreB Mrl
DS731_19520	COG1459	type II secretion system
DS731_19535	COG3267	Type II secretory pathway component ExeA
DS731_19535	COG3409	Peptidoglycan-binding domain 1 protein
DS731_19570	COG0110	maltose O-acetyltransferase activity
DS731_19595	COG0629	single-stranded DNA binding
DS731_19605	COG3250	beta-galactosidase activity
DS731_19610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DS731_19640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DS731_19645	COG1085	galactose-1-phosphate uridylyltransferase
DS731_19655	COG1609	Transcriptional regulator
DS731_19670	COG0490	domain, Protein
DS731_19670	COG0471	metal ion transport
DS731_19685	COG2814	Major facilitator Superfamily
DS731_19690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DS731_19710	COG2080	2 iron, 2 sulfur cluster binding
DS731_19715	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DS731_19720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DS731_19740	COG3842	ATPase activity
DS731_19745	COG4988	ABC transporter
DS731_19750	COG4890	Cyd operon protein YbgT
DS731_19755	COG1294	oxidase, subunit
DS731_19760	COG1271	oxidase subunit
DS731_19780	COG1566	PFAM secretion protein HlyD family protein
DS731_19815	COG0673	inositol 2-dehydrogenase activity
DS731_19835	COG4251	negative regulation of phosphorylation
DS731_19870	COG4206	TonB-dependent receptor
DS731_19895	COG1252	NADH dehydrogenase
DS731_19910	COG1012	belongs to the aldehyde dehydrogenase family
DS731_19915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_19920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS731_19925	COG1116	anion transmembrane transporter activity
DS731_19940	COG0583	DNA-binding transcription factor activity
DS731_19955	COG0842	Transport permease protein
DS731_19955	COG1129	ABC transporter
DS731_19960	COG1131	(ABC) transporter
DS731_19990	COG0348	domain, Protein
DS731_19990	COG3901	Regulator of nitric oxide reductase transcription
DS731_20005	COG0583	DNA-binding transcription factor activity
DS731_20010	COG2814	Major facilitator Superfamily
DS731_20025	COG2205	protein histidine kinase activity
DS731_20030	COG0745	RESPONSE REGULATOR receiver
DS731_20035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_20045	COG1538	Outer membrane efflux protein
DS731_20090	COG0463	Glycosyl transferase, family 2
DS731_20100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DS731_20105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_20115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DS731_20120	COG3038	cytochrome b561
DS731_20135	COG0583	DNA-binding transcription factor activity
DS731_20140	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS731_20145	COG2326	polyphosphate kinase activity
DS731_20175	COG0562	UDP-galactopyranose mutase
DS731_20180	COG0583	DNA-binding transcription factor activity
DS731_20220	COG4969	Belongs to the N-Me-Phe pilin family
DS731_20285	COG0805	protein transport
DS731_20295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS731_20315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS731_20320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DS731_20330	COG0673	inositol 2-dehydrogenase activity
DS731_20340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DS731_20345	COG3706	GGDEF domain
DS731_20365	COG2186	Transcriptional regulator
DS731_20385	COG4585	Histidine kinase
DS731_20390	COG2197	response regulator
DS731_20395	COG3940	Belongs to the glycosyl hydrolase 43 family
DS731_20400	COG3507	Belongs to the glycosyl hydrolase 43 family
DS731_20415	COG3940	Belongs to the glycosyl hydrolase 43 family
DS731_20420	COG2211	Major facilitator Superfamily
DS731_20435	COG3507	Belongs to the glycosyl hydrolase 43 family
DS731_20445	COG3534	alpha-L-arabinofuranosidase
DS731_20460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DS731_20475	COG1069	ribulokinase activity
DS731_20480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DS731_20485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DS731_20500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DS731_20505	COG2169	Transcriptional regulator
DS731_20520	COG3300	MHYT domain
DS731_20520	COG5001	Diguanylate cyclase
DS731_20530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_20535	COG1166	arginine decarboxylase activity
DS731_20540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DS731_20550	COG4771	TonB-dependent receptor
DS731_20555	COG0778	Nitroreductase
DS731_20585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DS731_20590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DS731_20595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DS731_20600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS731_20610	COG4191	Histidine kinase
DS731_20610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_20640	COG4232	protein-disulfide reductase activity
DS731_20660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DS731_20665	COG0511	ligase activity, forming carbon-carbon bonds
DS731_20670	COG0439	Biotin carboxylase
DS731_20735	COG0848	biopolymer transport protein
DS731_20740	COG0811	peptide transport
DS731_20745	COG0811	peptide transport
DS731_20770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS731_20775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DS731_20790	COG0151	Belongs to the GarS family
DS731_20800	COG3954	Phosphoribulokinase
DS731_20810	COG0745	RESPONSE REGULATOR receiver
DS731_20840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DS731_20850	COG3031	protein transport across the cell outer membrane
DS731_20860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DS731_20865	COG1459	type II secretion system
DS731_20870	COG2165	general secretion pathway protein
DS731_20875	COG2165	general secretion pathway protein
DS731_20885	COG4795	General secretion pathway protein
DS731_20890	COG3156	type II secretion system protein K
DS731_20900	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DS731_20915	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DS731_20920	COG1011	Hydrolase
DS731_20925	COG0494	nUDIX hydrolase
DS731_20930	COG1218	3'(2'),5'-bisphosphate nucleotidase
DS731_20950	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DS731_20960	COG0583	DNA-binding transcription factor activity
DS731_20970	COG3089	Belongs to the UPF0270 family
DS731_20975	COG0429	hydrolase of the alpha beta-hydrolase fold
DS731_20985	COG0488	(ABC) transporter
DS731_20990	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DS731_21005	COG2900	Belongs to the SlyX family
DS731_21015	COG0545	Peptidyl-prolyl cis-trans isomerase
DS731_21020	COG1902	pentaerythritol trinitrate reductase activity
DS731_21025	COG0693	protein deglycase activity
DS731_21035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS731_21055	COG2183	response to ionizing radiation
DS731_21060	COG2801	Transposase and inactivated derivatives
DS731_21065	COG2963	transposase activity
DS731_21085	COG3866	Pectate lyase
DS731_21105	COG0596	Alpha beta hydrolase
DS731_21130	COG0534	Mate efflux family protein
DS731_21150	COG0109	protoheme IX farnesyltransferase activity
DS731_21155	COG1612	heme a metabolic process
DS731_21180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DS731_21185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DS731_21190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DS731_21195	COG2353	YceI-like domain
DS731_21210	COG0583	DNA-binding transcription factor activity
DS731_21225	COG1609	Transcriptional regulator
DS731_21230	COG4771	TonB-dependent receptor
DS731_21235	COG3119	arylsulfatase activity
DS731_21240	COG3119	arylsulfatase activity
DS731_21245	COG3119	arylsulfatase activity
DS731_21280	COG0129	dihydroxy-acid dehydratase activity
DS731_21285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS731_21295	COG0606	chelatase, subunit chli
DS731_21300	COG0583	DNA-binding transcription factor activity
DS731_21315	COG2814	Major facilitator Superfamily
DS731_21320	COG0729	surface antigen
DS731_21325	COG2911	Protein conserved in bacteria
DS731_21330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS731_21350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DS731_21360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DS731_21380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DS731_21400	COG0402	S-adenosylhomocysteine deaminase activity
DS731_21425	COG2963	transposase activity
DS731_21430	COG2801	Transposase and inactivated derivatives
DS731_21435	COG0425	Belongs to the sulfur carrier protein TusA family
DS731_21440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DS731_21455	COG1561	YicC-like family, N-terminal region
DS731_21465	COG3727	T/G mismatch-specific endonuclease activity
DS731_21495	COG0625	glutathione transferase activity
DS731_21515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DS731_21535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DS731_21540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DS731_21560	COG1475	DNA binding
DS731_21565	COG1192	Involved in chromosome partitioning
DS731_21590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS731_21605	COG0706	membrane insertase activity
DS731_21610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DS731_21615	COG0594	ribonuclease P activity
DS731_21620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DS731_21710	COG3550	peptidyl-serine autophosphorylation
DS731_21725	COG4974	Belongs to the 'phage' integrase family
DS731_21775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DS731_21840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DS731_21865	COG2199	diguanylate cyclase activity
DS731_21865	COG2203	Gaf domain
DS731_21890	COG2124	cytochrome p450
DS731_21900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DS731_21910	COG1271	oxidase subunit
DS731_21915	COG1294	oxidase, subunit
DS731_21980	COG1192	Involved in chromosome partitioning
DS731_22070	COG3550	peptidyl-serine autophosphorylation
DS731_22085	COG4974	Belongs to the 'phage' integrase family
DS731_22140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily