locus-tag	class	description
BM528_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM528_00020	COG0187	DNA topoisomerase II activity
BM528_00055	COG2818	Glycosylase
BM528_00065	COG3078	GTPase activator activity
BM528_00085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM528_00085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM528_00095	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BM528_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM528_00105	COG0569	domain protein
BM528_00110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM528_00110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM528_00125	COG1652	LysM domain
BM528_00130	COG0758	DNA mediated transformation
BM528_00140	COG0551	DNA topoisomerase type I activity
BM528_00145	COG0009	L-threonylcarbamoyladenylate synthase
BM528_00150	COG0408	coproporphyrinogen oxidase activity
BM528_00155	COG3047	cAMP biosynthetic process
BM528_00170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BM528_00235	COG2234	aminopeptidase activity
BM528_00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM528_00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM528_00315	COG3642	lipopolysaccharide core region biosynthetic process
BM528_00320	COG0859	PFAM glycosyl transferase family 9
BM528_00350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_00365	COG3161	chorismate lyase activity
BM528_00370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM528_00375	COG2960	long-chain fatty acid transporting porin activity
BM528_00380	COG0210	DNA helicase
BM528_00450	COG5001	Diguanylate cyclase
BM528_00450	COG3300	MHYT domain
BM528_00480	COG3550	peptidyl-serine autophosphorylation
BM528_00485	COG1396	sequence-specific DNA binding
BM528_00540	COG3550	peptidyl-serine autophosphorylation
BM528_00565	COG4585	Histidine kinase
BM528_00570	COG2197	response regulator
BM528_00590	COG2855	membrane
BM528_00600	COG0656	L-ascorbic acid biosynthetic process
BM528_00615	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_00620	COG4771	TonB-dependent receptor
BM528_00650	COG4771	TonB-dependent receptor
BM528_00655	COG1960	acyl-CoA dehydrogenase activity
BM528_00660	COG0583	DNA-binding transcription factor activity
BM528_00670	COG3106	COG3106 Predicted ATPase
BM528_00685	COG3071	HemY protein
BM528_00690	COG2959	enzyme of heme biosynthesis
BM528_00700	COG0181	hydroxymethylbilane synthase activity
BM528_00705	COG0745	RESPONSE REGULATOR receiver
BM528_00705	COG3706	GGDEF domain
BM528_00710	COG0400	carboxylic ester hydrolase activity
BM528_00715	COG0194	GDP metabolic process
BM528_00725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM528_00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM528_00740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM528_00750	COG0678	peroxiredoxin activity
BM528_00765	COG1178	ABC-type Fe3 transport system permease component
BM528_00770	COG3842	ATPase activity
BM528_00775	COG2081	HI0933 family
BM528_00795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM528_00795	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM528_00815	COG2200	EAL domain
BM528_00850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_00865	COG0427	acetyl-CoA hydrolase
BM528_00870	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM528_00885	COG0840	transmembrane signaling receptor activity
BM528_00900	COG5002	protein histidine kinase activity
BM528_00900	COG5001	Diguanylate cyclase
BM528_00915	COG0514	ATP-dependent DNA helicase (RecQ)
BM528_00920	COG2239	Acts as a magnesium transporter
BM528_00930	COG3706	GGDEF domain
BM528_00930	COG0745	RESPONSE REGULATOR receiver
BM528_00935	COG0210	DNA helicase
BM528_00945	COG1011	Hydrolase
BM528_00960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM528_00965	COG0019	diaminopimelate decarboxylase activity
BM528_00980	COG0671	phosphoesterase, PA-phosphatase related
BM528_00995	COG0163	prenyltransferase activity
BM528_01000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM528_01010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BM528_01030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_01035	COG1136	(ABC) transporter
BM528_01035	COG0577	efflux transmembrane transporter activity
BM528_01050	COG1077	Cell shape determining protein MreB Mrl
BM528_01060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM528_01065	COG2814	Major facilitator Superfamily
BM528_01085	COG1085	galactose-1-phosphate uridylyltransferase
BM528_01090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BM528_01120	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_01145	COG1349	DNA-binding transcription factor activity
BM528_01160	COG1077	Cell shape determining protein MreB Mrl
BM528_01170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BM528_01180	COG1530	ribonuclease E activity
BM528_01185	COG3164	Protein of unknown function
BM528_01190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM528_01195	COG0312	modulator of DNA gyrase
BM528_01200	COG3028	Belongs to the UPF0307 family
BM528_01205	COG0312	modulator of DNA gyrase
BM528_01220	COG0745	RESPONSE REGULATOR receiver
BM528_01225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_01225	COG4191	Histidine kinase
BM528_01230	COG0297	glycogen (starch) synthase activity
BM528_01240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM528_01245	COG2226	methyltransferase
BM528_01245	COG0596	Alpha beta hydrolase
BM528_01245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM528_01285	COG3706	GGDEF domain
BM528_01295	COG0546	phosphoglycolate phosphatase activity
BM528_01310	COG1454	alcohol dehydrogenase
BM528_01315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_01395	COG0751	glycine-tRNA ligase activity
BM528_01400	COG5433	transposase activity
BM528_01415	COG0463	Glycosyl transferase, family 2
BM528_01435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM528_01455	COG1611	Belongs to the LOG family
BM528_01460	COG0745	RESPONSE REGULATOR receiver
BM528_01460	COG3706	GGDEF domain
BM528_01465	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_01465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_01490	COG4191	Histidine kinase
BM528_01555	COG1773	rubredoxin
BM528_01575	COG2204	response regulator
BM528_01585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BM528_01670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM528_01675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM528_01685	COG0156	8-amino-7-oxononanoate synthase activity
BM528_01695	COG0596	Alpha beta hydrolase
BM528_01700	COG0419	ATPase involved in DNA repair
BM528_01705	COG0420	3'-5' exonuclease activity
BM528_01730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM528_01735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM528_01740	COG3659	wide pore channel activity
BM528_01755	COG1739	Uncharacterized protein family UPF0029
BM528_01760	COG1451	nucleotide metabolic process
BM528_01765	COG3112	Uncharacterised protein family (UPF0231)
BM528_01830	COG0051	transcription antitermination factor activity, RNA binding
BM528_01845	COG0089	rRNA binding
BM528_01855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM528_01865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM528_01880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM528_01885	COG1519	Transferase
BM528_01900	COG0840	transmembrane signaling receptor activity
BM528_01915	COG0788	formyltetrahydrofolate deformylase activity
BM528_01925	COG1643	Atp-dependent helicase
BM528_01930	COG2203	Gaf domain
BM528_01930	COG4251	negative regulation of phosphorylation
BM528_01930	COG5001	Diguanylate cyclase
BM528_01930	COG3706	GGDEF domain
BM528_01940	COG2951	lytic endotransglycosylase activity
BM528_01945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM528_01955	COG2354	Protein conserved in bacteria
BM528_01970	COG0004	ammonium transporteR
BM528_01975	COG0405	Gamma-glutamyltransferase
BM528_01980	COG2837	iron assimilation
BM528_01995	COG0540	Belongs to the ATCase OTCase family
BM528_02005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_02020	COG3437	response regulator, receiver
BM528_02020	COG3850	Histidine kinase
BM528_02020	COG2205	protein histidine kinase activity
BM528_02020	COG4999	Histidine kinase
BM528_02035	COG5001	Diguanylate cyclase
BM528_02035	COG3300	MHYT domain
BM528_02045	COG1012	belongs to the aldehyde dehydrogenase family
BM528_02050	COG3138	arginine N-succinyltransferase
BM528_02055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM528_02065	COG0512	Glutamine amidotransferase of anthranilate synthase
BM528_02070	COG0180	Tryptophanyl-tRNA synthetase
BM528_02075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM528_02095	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BM528_02105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM528_02140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM528_02145	COG0281	malic enzyme
BM528_02160	COG0517	IMP dehydrogenase activity
BM528_02170	COG0746	molybdenum cofactor guanylyltransferase activity
BM528_02180	COG1116	anion transmembrane transporter activity
BM528_02190	COG1116	anion transmembrane transporter activity
BM528_02190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM528_02195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM528_02195	COG1648	precorrin-2 dehydrogenase activity
BM528_02200	COG0243	molybdopterin cofactor binding
BM528_02210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM528_02210	COG2146	nitrite reductase [NAD(P)H] activity
BM528_02215	COG2815	serine threonine protein kinase
BM528_02215	COG0515	serine threonine protein kinase
BM528_02220	COG2116	formate transmembrane transporter activity
BM528_02230	COG0303	'Molybdopterin
BM528_02240	COG0625	glutathione transferase activity
BM528_02255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM528_02255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BM528_02265	COG0137	argininosuccinate synthase activity
BM528_02270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BM528_02285	COG1803	Methylglyoxal synthase
BM528_02290	COG3678	ATP-independent chaperone mediated protein folding
BM528_02295	COG0745	RESPONSE REGULATOR receiver
BM528_02310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM528_02325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM528_02330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_02335	COG4942	peptidase
BM528_02350	COG0584	glycerophosphoryl diester phosphodiesterase
BM528_02370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BM528_02395	COG0028	Belongs to the TPP enzyme family
BM528_02415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BM528_02420	COG0805	protein transport
BM528_02430	COG0084	hydrolase, TatD family'
BM528_02435	COG3706	GGDEF domain
BM528_02445	COG0248	Ppx GppA phosphatase
BM528_02450	COG0513	Belongs to the DEAD box helicase family
BM528_02455	COG3118	belongs to the thioredoxin family
BM528_02460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BM528_02480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM528_02490	COG2847	Copper chaperone PCu(A)C
BM528_02495	COG0783	Belongs to the Dps family
BM528_02500	COG2133	pyrroloquinoline quinone binding
BM528_02505	COG4946	Tricorn protease homolog
BM528_02505	COG0823	Involved in the tonB-independent uptake of proteins
BM528_02505	COG1506	peptidase
BM528_02515	COG3118	belongs to the thioredoxin family
BM528_02530	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BM528_02540	COG1012	belongs to the aldehyde dehydrogenase family
BM528_02560	COG1757	Na H antiporter
BM528_02570	COG3876	Protein conserved in bacteria
BM528_02575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM528_02650	COG3547	Transposase (IS116 IS110 IS902 family)
BM528_02750	COG0183	Belongs to the thiolase family
BM528_02755	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM528_02755	COG1024	Enoyl-CoA hydratase
BM528_02765	COG0006	proline dipeptidase activity
BM528_02775	COG0142	geranyltranstransferase activity
BM528_02805	COG1388	LysM domain
BM528_02805	COG4942	peptidase
BM528_02810	COG1238	metal cluster binding
BM528_02820	COG0585	pseudouridine synthase activity
BM528_02835	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BM528_02845	COG0840	transmembrane signaling receptor activity
BM528_02860	COG3025	triphosphatase activity
BM528_02870	COG3066	DNA modification
BM528_02875	COG0494	nUDIX hydrolase
BM528_02880	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BM528_02885	COG0730	response to heat
BM528_02890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BM528_02900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM528_02925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM528_02950	COG2201	protein-glutamate methylesterase activity
BM528_02955	COG3706	GGDEF domain
BM528_02960	COG2211	Major facilitator Superfamily
BM528_02980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM528_02990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM528_03000	COG1648	precorrin-2 dehydrogenase activity
BM528_03000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM528_03005	COG0513	Belongs to the DEAD box helicase family
BM528_03020	COG1538	Outer membrane efflux protein
BM528_03025	COG0494	nUDIX hydrolase
BM528_03030	COG3151	Protein conserved in bacteria
BM528_03035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM528_03040	COG3150	esterase
BM528_03045	COG0187	DNA topoisomerase II activity
BM528_03070	COG1509	lysine 2,3-aminomutase activity
BM528_03080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BM528_03115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM528_03130	COG0271	Belongs to the BolA IbaG family
BM528_03135	COG0671	phosphoesterase, PA-phosphatase related
BM528_03150	COG0659	secondary active sulfate transmembrane transporter activity
BM528_03165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM528_03175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM528_03185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BM528_03190	COG0348	domain, Protein
BM528_03205	COG1960	acyl-CoA dehydrogenase activity
BM528_03210	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_03220	COG4948	Mandelate Racemase Muconate Lactonizing
BM528_03240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_03245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_03265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM528_03270	COG0358	DNA primase activity
BM528_03295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM528_03315	COG0537	adenosine 5'-monophosphoramidase activity
BM528_03330	COG2974	May be involved in recombination
BM528_03340	COG0745	RESPONSE REGULATOR receiver
BM528_03345	COG5002	protein histidine kinase activity
BM528_03375	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BM528_03390	COG0527	aspartate kinase activity
BM528_03410	COG2967	ApaG domain
BM528_03415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BM528_03420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM528_03425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM528_03430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BM528_03435	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BM528_03445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM528_03450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BM528_03465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM528_03480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM528_03485	COG3956	TIGRFAM MazG family protein
BM528_03510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM528_03520	COG2801	Transposase and inactivated derivatives
BM528_03540	COG3474	cytochrome
BM528_03550	COG4771	TonB-dependent receptor
BM528_03565	COG3119	arylsulfatase activity
BM528_03570	COG2814	Major facilitator Superfamily
BM528_03575	COG1404	Belongs to the peptidase S8 family
BM528_03580	COG1132	(ABC) transporter
BM528_03595	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_03620	COG1012	belongs to the aldehyde dehydrogenase family
BM528_03640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM528_03665	COG0723	plastoquinol--plastocyanin reductase activity
BM528_03670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM528_03675	COG2857	Cytochrome c1
BM528_03680	COG0625	glutathione transferase activity
BM528_03685	COG2969	positive regulation of protein catabolic process
BM528_03690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_03705	COG2239	Acts as a magnesium transporter
BM528_03710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM528_03720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM528_03730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BM528_03735	COG1137	ATPase activity
BM528_03740	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BM528_03765	COG1127	ABC transporter
BM528_03770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM528_03775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM528_03780	COG2854	intermembrane phospholipid transfer
BM528_03790	COG5007	Belongs to the BolA IbaG family
BM528_03800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM528_03805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM528_03815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM528_03850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_03860	COG3706	GGDEF domain
BM528_03865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM528_03870	COG0612	Peptidase, M16
BM528_03880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM528_03905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM528_03915	COG0126	phosphoglycerate kinase activity
BM528_03920	COG3588	fructose-bisphosphate aldolase
BM528_03925	COG4946	Tricorn protease homolog
BM528_03925	COG1506	peptidase
BM528_03925	COG0823	Involved in the tonB-independent uptake of proteins
BM528_03930	COG2311	Membrane
BM528_03935	COG0248	Ppx GppA phosphatase
BM528_03940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM528_03950	COG0573	inorganic phosphate transmembrane transporter activity
BM528_03960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM528_03970	COG0306	phosphate transporter
BM528_03975	COG0589	response to stress
BM528_03980	COG0583	DNA-binding transcription factor activity
BM528_03990	COG1272	protein, Hemolysin III
BM528_04000	COG1846	Transcriptional regulator
BM528_04005	COG1764	response to oxidative stress
BM528_04025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_04055	COG1346	cytolysis
BM528_04085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM528_04090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BM528_04095	COG0513	Belongs to the DEAD box helicase family
BM528_04100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM528_04110	COG3267	Type II secretory pathway component ExeA
BM528_04110	COG3409	Peptidoglycan-binding domain 1 protein
BM528_04130	COG0066	3-isopropylmalate dehydratase activity
BM528_04140	COG0473	3-isopropylmalate dehydrogenase activity
BM528_04145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM528_04165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BM528_04180	COG4555	ABC transporter
BM528_04185	COG1668	transmembrane transport
BM528_04200	COG4133	protoheme IX ABC transporter activity
BM528_04205	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM528_04210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM528_04215	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM528_04225	COG1138	Cytochrome C-type biogenesis protein
BM528_04245	COG2853	Lipoprotein
BM528_04250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM528_04260	COG3104	oligopeptide transport
BM528_04265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BM528_04270	COG1555	photosystem II stabilization
BM528_04270	COG1596	polysaccharide export
BM528_04275	COG0473	3-isopropylmalate dehydrogenase activity
BM528_04295	COG1611	Belongs to the LOG family
BM528_04300	COG3706	GGDEF domain
BM528_04305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_04305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_04350	COG0811	peptide transport
BM528_04355	COG0811	peptide transport
BM528_04360	COG0848	biopolymer transport protein
BM528_04365	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BM528_04375	COG3437	response regulator, receiver
BM528_04380	COG5002	protein histidine kinase activity
BM528_04380	COG2205	protein histidine kinase activity
BM528_04380	COG0784	Response regulator, receiver
BM528_04390	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_04400	COG2133	pyrroloquinoline quinone binding
BM528_04405	COG1049	propionate catabolic process, 2-methylcitrate cycle
BM528_04440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BM528_04445	COG0024	Methionine aminopeptidase
BM528_04450	COG0052	Belongs to the universal ribosomal protein uS2 family
BM528_04460	COG0528	UMP kinase activity
BM528_04470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BM528_04475	COG0575	Belongs to the CDS family
BM528_04480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BM528_04500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM528_04520	COG0587	DNA-directed DNA polymerase activity
BM528_04525	COG0825	malonyl-CoA metabolic process
BM528_04530	COG0037	tRNA processing
BM528_04535	COG3706	GGDEF domain
BM528_04550	COG0513	Belongs to the DEAD box helicase family
BM528_04555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BM528_04560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BM528_04565	COG0583	DNA-binding transcription factor activity
BM528_04585	COG1760	l-serine dehydratase
BM528_04595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM528_04605	COG1322	Protein conserved in bacteria
BM528_04620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM528_04625	COG0022	dehydrogenase e1 component
BM528_04635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BM528_04645	COG1946	Acyl-CoA thioesterase
BM528_04655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM528_04665	COG1956	GAF domain-containing protein
BM528_04680	COG0793	Belongs to the peptidase S41A family
BM528_04685	COG0733	neurotransmitter:sodium symporter activity
BM528_04695	COG0308	aminopeptidase N
BM528_04725	COG2902	Dehydrogenase
BM528_04730	COG0167	dihydroorotate dehydrogenase activity
BM528_04755	COG3130	regulation of translation
BM528_04760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM528_04770	COG0415	Belongs to the DNA photolyase family
BM528_04780	COG0415	Belongs to the DNA photolyase family
BM528_04785	COG0415	Belongs to the DNA photolyase family
BM528_04790	COG3046	protein related to deoxyribodipyrimidine photolyase
BM528_04830	COG5002	protein histidine kinase activity
BM528_04835	COG0745	RESPONSE REGULATOR receiver
BM528_04860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_04905	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_04975	COG0375	protein maturation
BM528_04985	COG0409	Hydrogenase expression formation protein
BM528_04995	COG0309	Hydrogenase expression formation protein (HypE)
BM528_05000	COG0789	Transcriptional regulator
BM528_05005	COG2217	Heavy metal translocating P-type atpase
BM528_05035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BM528_05070	COG0589	response to stress
BM528_05080	COG0069	glutamate synthase activity
BM528_05085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM528_05085	COG4651	solute:proton antiporter activity
BM528_05095	COG2193	ferroxidase activity
BM528_05110	COG3278	Belongs to the heme-copper respiratory oxidase family
BM528_05125	COG2010	Cytochrome c
BM528_05155	COG0589	response to stress
BM528_05160	COG0037	tRNA processing
BM528_05165	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM528_05185	COG1280	lysine exporter protein (LysE YggA)
BM528_05190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BM528_05195	COG2897	thiosulfate sulfurtransferase activity
BM528_05200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BM528_05210	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM528_05240	COG0322	excinuclease ABC activity
BM528_05245	COG2197	response regulator
BM528_05260	COG0670	Belongs to the BI1 family
BM528_05265	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BM528_05280	COG2920	part of a sulfur-relay system
BM528_05290	COG4191	Histidine kinase
BM528_05295	COG0840	transmembrane signaling receptor activity
BM528_05305	COG3447	MASE1 domain protein
BM528_05305	COG5002	protein histidine kinase activity
BM528_05305	COG5001	Diguanylate cyclase
BM528_05330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BM528_05340	COG1674	ftsk spoiiie
BM528_05340	COG0531	amino acid
BM528_05350	COG0686	Belongs to the AlaDH PNT family
BM528_05355	COG0284	orotidine-5'-phosphate decarboxylase activity
BM528_05360	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BM528_05365	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BM528_05375	COG0776	regulation of translation
BM528_05380	COG0539	negative regulation of cytoplasmic translation
BM528_05385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM528_05390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM528_05395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BM528_05405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM528_05410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM528_05415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM528_05420	COG0633	Ferredoxin
BM528_05435	COG2200	EAL domain
BM528_05460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BM528_05465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM528_05475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM528_05485	COG4783	chaperone-mediated protein folding
BM528_05495	COG1393	Belongs to the ArsC family
BM528_05510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM528_05525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM528_05535	COG1960	acyl-CoA dehydrogenase activity
BM528_05555	COG0572	uridine kinase
BM528_05560	COG3769	mannosylglycerate metabolic process
BM528_05565	COG1215	transferase activity, transferring glycosyl groups
BM528_05580	COG0303	'Molybdopterin
BM528_05585	COG0534	Mate efflux family protein
BM528_05595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM528_05600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM528_05610	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM528_05630	COG1448	Aminotransferase
BM528_05660	COG1671	Belongs to the UPF0178 family
BM528_05665	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_05670	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_05675	COG2130	NADP-dependent
BM528_05680	COG1960	acyl-CoA dehydrogenase activity
BM528_05685	COG0662	Cupin 2, conserved barrel domain protein
BM528_05685	COG2207	Transcriptional regulator
BM528_05700	COG1505	serine-type exopeptidase activity
BM528_05740	COG0596	Alpha beta hydrolase
BM528_05750	COG0716	FMN binding
BM528_05760	COG0735	belongs to the Fur family
BM528_05770	COG1984	allophanate hydrolase subunit 2
BM528_05780	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BM528_05785	COG2996	Protein conserved in bacteria
BM528_05790	COG1765	OsmC-like protein
BM528_05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_05805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_05820	COG0436	Aminotransferase
BM528_05825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM528_05830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BM528_05850	COG3012	SEC-C Motif Domain Protein
BM528_05865	COG3706	GGDEF domain
BM528_05865	COG0745	RESPONSE REGULATOR receiver
BM528_05870	COG0702	epimerase
BM528_05880	COG0084	hydrolase, TatD family'
BM528_05895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BM528_05900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM528_05905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM528_05910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM528_05925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM528_05930	COG0416	fatty acid biosynthetic process
BM528_05940	COG1399	metal-binding, possibly nucleic acid-binding protein
BM528_05950	COG0546	phosphoglycolate phosphatase activity
BM528_05960	COG1530	ribonuclease E activity
BM528_05980	COG1012	belongs to the aldehyde dehydrogenase family
BM528_05985	COG2207	Transcriptional regulator
BM528_05985	COG3708	Transcriptional regulator
BM528_05990	COG0612	Peptidase, M16
BM528_06005	COG1185	polyribonucleotide nucleotidyltransferase activity
BM528_06030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_06045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM528_06050	COG0149	triose-phosphate isomerase activity
BM528_06055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM528_06060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM528_06065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM528_06070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BM528_06075	COG1534	Rna-binding protein
BM528_06085	COG1067	ATP-dependent peptidase activity
BM528_06090	COG0495	leucyl-tRNA aminoacylation
BM528_06105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BM528_06110	COG0799	negative regulation of ribosome biogenesis
BM528_06115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BM528_06120	COG0768	penicillin binding
BM528_06125	COG0772	Belongs to the SEDS family
BM528_06130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM528_06135	COG1686	Belongs to the peptidase S11 family
BM528_06140	COG2921	Belongs to the UPF0250 family
BM528_06145	COG0321	lipoyl(octanoyl) transferase activity
BM528_06150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM528_06155	COG0252	asparaginase activity
BM528_06165	COG0778	Nitroreductase
BM528_06175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_06185	COG0616	signal peptide processing
BM528_06190	COG3092	negative regulation of chromosome organization
BM528_06195	COG0492	ferredoxin-NADP+ reductase activity
BM528_06200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BM528_06205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BM528_06210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM528_06215	COG0542	response to heat
BM528_06220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM528_06225	COG1278	Cold shock
BM528_06240	COG1187	pseudouridine synthase activity
BM528_06245	COG0482	sulfurtransferase activity
BM528_06250	COG2915	High frequency lysogenization protein hflD homolog
BM528_06255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM528_06260	COG2850	peptidyl-arginine hydroxylation
BM528_06275	COG0574	Belongs to the PEP-utilizing enzyme family
BM528_06275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM528_06285	COG0457	Tetratricopeptide repeat
BM528_06290	COG2153	protein acetylation
BM528_06300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM528_06305	COG3724	N-succinylarginine dihydrolase activity
BM528_06315	COG1301	dicarboxylic acid transport
BM528_06320	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM528_06325	COG1136	(ABC) transporter
BM528_06330	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM528_06360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM528_06365	COG0328	RNA-DNA hybrid ribonuclease activity
BM528_06370	COG3321	synthase
BM528_06370	COG0604	alcohol dehydrogenase
BM528_06390	COG1643	Atp-dependent helicase
BM528_06405	COG2925	Exonuclease
BM528_06430	COG0183	Belongs to the thiolase family
BM528_06435	COG0789	Transcriptional regulator
BM528_06440	COG1960	acyl-CoA dehydrogenase activity
BM528_06445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BM528_06450	COG1024	Enoyl-CoA hydratase
BM528_06490	COG2814	Major facilitator Superfamily
BM528_06525	COG0708	Exodeoxyribonuclease III
BM528_06550	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM528_06560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM528_06570	COG2096	Adenosyltransferase
BM528_06580	COG4771	TonB-dependent receptor
BM528_06590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BM528_06600	COG1472	Belongs to the glycosyl hydrolase 3 family
BM528_06625	COG0072	phenylalanine-tRNA ligase activity
BM528_06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM528_06645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM528_06675	COG0154	amidase activity
BM528_06685	COG0730	response to heat
BM528_06690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM528_06720	COG0784	Response regulator, receiver
BM528_06720	COG2205	protein histidine kinase activity
BM528_06725	COG3706	GGDEF domain
BM528_06725	COG5001	Diguanylate cyclase
BM528_06725	COG4251	negative regulation of phosphorylation
BM528_06725	COG2203	Gaf domain
BM528_06735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM528_06740	COG2252	PERMEase
BM528_06755	COG1309	transcriptional regulator
BM528_06780	COG2351	hydroxyisourate hydrolase activity
BM528_06785	COG0402	S-adenosylhomocysteine deaminase activity
BM528_06795	COG0745	RESPONSE REGULATOR receiver
BM528_06810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM528_06860	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BM528_06885	COG1393	Belongs to the ArsC family
BM528_06915	COG2988	succinylglutamate desuccinylase activity
BM528_06930	COG0330	HflC and HflK could
BM528_06940	COG0058	SHG alpha-glucan phosphorylase activity
BM528_06945	COG0033	Phosphoglucomutase
BM528_06950	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BM528_06955	COG0714	Associated with various cellular activities
BM528_06980	COG2363	Small membrane protein
BM528_06990	COG0583	DNA-binding transcription factor activity
BM528_07005	COG3094	Invasion gene expression up-regulator, SirB
BM528_07010	COG0784	Response regulator, receiver
BM528_07010	COG3437	response regulator, receiver
BM528_07015	COG2890	protein-(glutamine-N5) methyltransferase activity
BM528_07025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM528_07030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BM528_07035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM528_07045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM528_07055	COG1064	alcohol dehydrogenase
BM528_07065	COG1064	alcohol dehydrogenase
BM528_07080	COG0012	GTP binding
BM528_07085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM528_07125	COG1115	amino acid carrier protein
BM528_07145	COG1199	ATP-dependent helicase activity
BM528_07180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM528_07185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM528_07190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM528_07195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM528_07195	COG0131	Imidazoleglycerol-phosphate dehydratase
BM528_07200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM528_07215	COG0140	phosphoribosyl-ATP diphosphatase activity
BM528_07215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BM528_07230	COG0326	Molecular chaperone. Has ATPase activity
BM528_07235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM528_07255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BM528_07265	COG3220	belongs to the UPF0276 family
BM528_07300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM528_07310	COG1702	phosphate starvation-inducible protein PhoH
BM528_07320	COG4535	Mg2 and Co2 transporter CorC
BM528_07325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM528_07340	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BM528_07345	COG2944	sequence-specific DNA binding
BM528_07360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM528_07375	COG0280	phosphate acetyltransferase
BM528_07375	COG0857	belongs to the CobB CobQ family
BM528_07380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BM528_07385	COG0071	Belongs to the small heat shock protein (HSP20) family
BM528_07395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM528_07400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM528_07410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM528_07425	COG3909	cytochrome
BM528_07435	COG0484	heat shock protein binding
BM528_07445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM528_07455	COG0784	Response regulator, receiver
BM528_07455	COG5002	protein histidine kinase activity
BM528_07460	COG3562	capsule polysaccharide
BM528_07480	COG0625	glutathione transferase activity
BM528_07495	COG2610	gluconate transmembrane transporter activity
BM528_07500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM528_07510	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_07515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BM528_07520	COG0783	Belongs to the Dps family
BM528_07530	COG0497	DNA recombination
BM528_07535	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM528_07540	COG0500	methyltransferase
BM528_07550	COG1629	transport
BM528_07550	COG4774	siderophore transport
BM528_07565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM528_07570	COG2733	membrane
BM528_07580	COG0110	maltose O-acetyltransferase activity
BM528_07595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM528_07610	COG0656	L-ascorbic acid biosynthetic process
BM528_07615	COG1187	pseudouridine synthase activity
BM528_07620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BM528_07630	COG0009	L-threonylcarbamoyladenylate synthase
BM528_07635	COG0613	PHP domain protein
BM528_07640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM528_07650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM528_07655	COG0135	phosphoribosylanthranilate isomerase activity
BM528_07655	COG0134	indole-3-glycerol-phosphate synthase activity
BM528_07670	COG2350	Protein conserved in bacteria
BM528_07685	COG0745	RESPONSE REGULATOR receiver
BM528_07690	COG2205	protein histidine kinase activity
BM528_07695	COG0628	permease
BM528_07700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM528_07705	COG1090	epimerase
BM528_07710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BM528_07715	COG4181	ATPase activity
BM528_07720	COG2755	lipolytic protein G-D-S-L family
BM528_07740	COG0402	S-adenosylhomocysteine deaminase activity
BM528_07745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM528_07785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM528_07810	COG0745	RESPONSE REGULATOR receiver
BM528_07815	COG5002	protein histidine kinase activity
BM528_07815	COG2205	protein histidine kinase activity
BM528_07815	COG0784	Response regulator, receiver
BM528_07835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM528_07840	COG5265	(ABC) transporter
BM528_07855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BM528_07865	COG4139	cobalamin transport
BM528_07870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM528_07875	COG3340	Belongs to the peptidase S51 family
BM528_07885	COG1073	alpha beta
BM528_07885	COG2226	methyltransferase
BM528_07890	COG0156	8-amino-7-oxononanoate synthase activity
BM528_07945	COG0017	Asparaginyl-tRNA synthetase
BM528_07950	COG2031	fatty acid transporter
BM528_07960	COG2995	paraquat-inducible protein a
BM528_07965	COG3008	intermembrane lipid transfer
BM528_07965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM528_07975	COG3706	GGDEF domain
BM528_07980	COG1566	PFAM secretion protein HlyD family protein
BM528_07995	COG1309	transcriptional regulator
BM528_08005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_08035	COG3706	GGDEF domain
BM528_08070	COG1401	restriction endodeoxyribonuclease activity
BM528_08125	COG1484	DNA-dependent DNA replication
BM528_08140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BM528_08160	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BM528_08165	COG2885	chlorophyll binding
BM528_08170	COG0823	Involved in the tonB-independent uptake of proteins
BM528_08185	COG0811	peptide transport
BM528_08190	COG0824	Thioesterase
BM528_08195	COG2255	four-way junction helicase activity
BM528_08210	COG0494	nUDIX hydrolase
BM528_08215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM528_08225	COG2204	response regulator
BM528_08235	COG2205	protein histidine kinase activity
BM528_08265	COG0023	Translation Initiation Factor
BM528_08270	COG0745	RESPONSE REGULATOR receiver
BM528_08275	COG1605	Chorismate mutase
BM528_08275	COG0077	Prephenate dehydratase
BM528_08280	COG0287	Prephenate dehydrogenase
BM528_08280	COG1605	Chorismate mutase
BM528_08285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM528_08300	COG0335	large ribosomal subunit rRNA binding
BM528_08305	COG0336	Belongs to the RNA methyltransferase TrmD family
BM528_08310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BM528_08315	COG0228	four-way junction DNA binding
BM528_08325	COG0668	transmembrane transport
BM528_08330	COG1132	(ABC) transporter
BM528_08340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_08370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM528_08375	COG4137	Cytochrome C assembly protein
BM528_08380	COG4536	flavin adenine dinucleotide binding
BM528_08390	COG2062	phosphohistidine phosphatase, SixA
BM528_08395	COG1025	Belongs to the peptidase M16 family
BM528_08410	COG1024	Enoyl-CoA hydratase
BM528_08410	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM528_08420	COG0714	Associated with various cellular activities
BM528_08440	COG2304	oxidoreductase activity
BM528_08465	COG3706	GGDEF domain
BM528_08470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_08475	COG0175	sulfate reduction
BM528_08480	COG0529	Catalyzes the synthesis of activated sulfate
BM528_08495	COG0471	metal ion transport
BM528_08495	COG3273	potassium ion transport
BM528_08515	COG0367	asparagine synthase
BM528_08525	COG0602	queuosine metabolic process
BM528_08550	COG0556	nucleotide-excision repair
BM528_08555	COG0534	Mate efflux family protein
BM528_08575	COG2878	Part of a membrane complex involved in electron transport
BM528_08580	COG4656	Part of a membrane complex involved in electron transport
BM528_08585	COG4658	electron transport chain
BM528_08590	COG4659	FMN binding
BM528_08595	COG4660	Part of a membrane complex involved in electron transport
BM528_08600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM528_08615	COG1278	Cold shock
BM528_08620	COG0346	lactoylglutathione lyase activity
BM528_08625	COG0584	glycerophosphoryl diester phosphodiesterase
BM528_08660	COG4771	TonB-dependent receptor
BM528_08665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM528_08680	COG2719	SpoVR family
BM528_08685	COG2718	Belongs to the UPF0229 family
BM528_08690	COG2766	serine protein kinase
BM528_08700	COG2890	protein-(glutamine-N5) methyltransferase activity
BM528_08705	COG2840	Smr protein MutS2
BM528_08720	COG0612	Peptidase, M16
BM528_08730	COG0564	pseudouridine synthase activity
BM528_08735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM528_08740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM528_08770	COG3706	GGDEF domain
BM528_08770	COG0745	RESPONSE REGULATOR receiver
BM528_08780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM528_08830	COG0668	transmembrane transport
BM528_08840	COG4584	PFAM Integrase catalytic
BM528_08875	COG4584	PFAM Integrase catalytic
BM528_08880	COG1484	DNA-dependent DNA replication
BM528_08905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BM528_09000	COG1484	DNA-dependent DNA replication
BM528_09045	COG0789	Transcriptional regulator
BM528_09060	COG0789	Transcriptional regulator
BM528_09065	COG0640	Transcriptional regulator
BM528_09075	COG1230	cation diffusion facilitator family transporter
BM528_09095	COG1538	Outer membrane efflux protein
BM528_09105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_09125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM528_09140	COG0681	Belongs to the peptidase S26 family
BM528_09160	COG1074	ATP-dependent DNA helicase activity
BM528_09170	COG1404	Belongs to the peptidase S8 family
BM528_09175	COG0464	growth
BM528_09195	COG0629	single-stranded DNA binding
BM528_09210	COG0714	Associated with various cellular activities
BM528_09235	COG2003	Belongs to the UPF0758 family
BM528_09255	COG0583	DNA-binding transcription factor activity
BM528_09340	COG3620	sequence-specific DNA binding
BM528_09360	COG0456	acetyltransferase
BM528_09400	COG1444	tRNA N-acetyltransferase activity
BM528_09415	COG0848	biopolymer transport protein
BM528_09420	COG0811	peptide transport
BM528_09425	COG0811	peptide transport
BM528_09465	COG1522	sequence-specific DNA binding
BM528_09470	COG0625	glutathione transferase activity
BM528_09485	COG3186	Phenylalanine-4-hydroxylase
BM528_09500	COG1842	Phage shock protein A
BM528_09505	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BM528_09510	COG0747	negative chemotaxis
BM528_09515	COG4168	peptide transport system, permease
BM528_09520	COG4171	peptide transport system, permease
BM528_09530	COG4172	Belongs to the ABC transporter superfamily
BM528_09540	COG0511	ligase activity, forming carbon-carbon bonds
BM528_09540	COG5016	pyruvate
BM528_09570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM528_09585	COG3590	peptidase
BM528_09590	COG1309	transcriptional regulator
BM528_09595	COG0659	secondary active sulfate transmembrane transporter activity
BM528_09600	COG0288	reversible hydration of carbon dioxide
BM528_09605	COG0583	DNA-binding transcription factor activity
BM528_09610	COG0583	DNA-binding transcription factor activity
BM528_09615	COG3123	guanosine phosphorylase activity
BM528_09625	COG1410	methionine synthase
BM528_09625	COG0646	methionine synthase
BM528_09630	COG1410	methionine synthase
BM528_09630	COG0646	methionine synthase
BM528_09645	COG0835	chemotaxis
BM528_09655	COG1192	Involved in chromosome partitioning
BM528_09665	COG0643	Histidine kinase
BM528_09665	COG2198	Histidine kinase
BM528_09670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BM528_09685	COG0455	bacterial-type flagellum organization
BM528_09695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BM528_09710	COG1987	bacterial-type flagellum assembly
BM528_09760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BM528_09765	COG1766	The M ring may be actively involved in energy transduction
BM528_09770	COG1677	Flagellar hook-basal body complex protein FliE
BM528_09775	COG2204	response regulator
BM528_09795	COG1086	Polysaccharide biosynthesis protein
BM528_09800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM528_09805	COG1083	cytidylyl-transferase
BM528_09820	COG2089	acid synthase
BM528_09830	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_09845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BM528_09850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM528_09850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM528_09855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BM528_09870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM528_09875	COG3959	Transketolase, thiamine diphosphate binding domain
BM528_09880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BM528_09910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BM528_09945	COG1256	bacterial-type flagellum assembly
BM528_09950	COG3951	Flagellar rod assembly protein muramidase FlgJ
BM528_09950	COG1705	Flagellar rod assembly protein muramidase FlgJ
BM528_09965	COG4786	Flagellar basal body rod
BM528_09970	COG4787	bacterial-type flagellum-dependent cell motility
BM528_09975	COG1749	Flagellar hook protein flgE
BM528_09980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BM528_09985	COG1558	bacterial-type flagellum-dependent cell motility
BM528_09990	COG1815	bacterial-type flagellum-dependent cell motility
BM528_09995	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BM528_10000	COG0835	chemotaxis
BM528_10000	COG0784	Response regulator, receiver
BM528_10035	COG2840	Smr protein MutS2
BM528_10045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM528_10045	COG0047	phosphoribosylformylglycinamidine synthase activity
BM528_10055	COG0590	tRNA wobble adenosine to inosine editing
BM528_10075	COG0745	RESPONSE REGULATOR receiver
BM528_10085	COG0205	6-phosphofructokinase activity
BM528_10090	COG3279	Response regulator of the LytR AlgR family
BM528_10095	COG3275	phosphorelay sensor kinase activity
BM528_10115	COG0739	heme binding
BM528_10125	COG3081	Nucleoid-associated protein
BM528_10130	COG3082	Protein of unknown function (DUF1414)
BM528_10135	COG3083	sulfuric ester hydrolase activity
BM528_10140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM528_10145	COG2226	methyltransferase
BM528_10150	COG1024	Enoyl-CoA hydratase
BM528_10155	COG1960	acyl-CoA dehydrogenase activity
BM528_10165	COG2084	Dehydrogenase
BM528_10170	COG0386	Belongs to the glutathione peroxidase family
BM528_10175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM528_10180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM528_10185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BM528_10195	COG0616	signal peptide processing
BM528_10200	COG2267	carboxylic ester hydrolase activity
BM528_10205	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_10230	COG0366	Alpha amylase catalytic
BM528_10250	COG4667	esterase of the alpha-beta hydrolase superfamily
BM528_10275	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM528_10280	COG0567	Dehydrogenase, E1 component
BM528_10285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BM528_10290	COG1053	succinate dehydrogenase
BM528_10295	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BM528_10300	COG2009	succinate dehydrogenase
BM528_10305	COG0372	Belongs to the citrate synthase family
BM528_10320	COG0435	Glutathione S-transferase
BM528_10325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BM528_10360	COG1663	tetraacyldisaccharide 4'-kinase activity
BM528_10365	COG1132	(ABC) transporter
BM528_10370	COG0658	competence protein
BM528_10370	COG2333	competence protein COMEC
BM528_10380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM528_10390	COG1196	nuclear chromosome segregation
BM528_10410	COG0295	cytidine deaminase activity
BM528_10415	COG0405	Gamma-glutamyltransferase
BM528_10420	COG1024	Enoyl-CoA hydratase
BM528_10440	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM528_10445	COG4771	TonB-dependent receptor
BM528_10450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM528_10460	COG2914	Belongs to the UPF0125 (RnfH) family
BM528_10465	COG2867	negative regulation of translational initiation
BM528_10475	COG1902	pentaerythritol trinitrate reductase activity
BM528_10485	COG2814	Major facilitator Superfamily
BM528_10490	COG4771	TonB-dependent receptor
BM528_10495	COG5001	Diguanylate cyclase
BM528_10495	COG4251	negative regulation of phosphorylation
BM528_10495	COG2203	Gaf domain
BM528_10495	COG3706	GGDEF domain
BM528_10505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM528_10510	COG4136	ATPase activity
BM528_10520	COG4134	Bacterial extracellular solute-binding protein
BM528_10530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_10550	COG1032	radical SAM domain protein
BM528_10585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM528_10595	COG0450	alkyl hydroperoxide reductase
BM528_10615	COG0501	Belongs to the peptidase M48B family
BM528_10660	COG3153	acetyltransferase
BM528_10660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM528_10680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM528_10695	COG0195	Participates in both transcription termination and antitermination
BM528_10705	COG3437	response regulator, receiver
BM528_10710	COG0784	Response regulator, receiver
BM528_10710	COG2198	Histidine kinase
BM528_10710	COG2205	protein histidine kinase activity
BM528_10730	COG4771	TonB-dependent receptor
BM528_10760	COG0596	Alpha beta hydrolase
BM528_10765	COG1960	acyl-CoA dehydrogenase activity
BM528_10770	COG0183	Belongs to the thiolase family
BM528_10775	COG1024	Enoyl-CoA hydratase
BM528_10775	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM528_10780	COG0596	Alpha beta hydrolase
BM528_10790	COG0604	alcohol dehydrogenase
BM528_10820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM528_10825	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BM528_10825	COG1618	nucleotide phosphatase activity, acting on free nucleotides
BM528_10845	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM528_10855	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM528_10860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BM528_10870	COG0436	Aminotransferase
BM528_10875	COG3268	Saccharopine dehydrogenase
BM528_10880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM528_10905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM528_10910	COG1074	ATP-dependent DNA helicase activity
BM528_10915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BM528_10930	COG1022	Amp-dependent synthetase and ligase
BM528_10935	COG3300	MHYT domain
BM528_10935	COG5001	Diguanylate cyclase
BM528_10975	COG0583	DNA-binding transcription factor activity
BM528_10980	COG2204	response regulator
BM528_10990	COG4251	negative regulation of phosphorylation
BM528_10995	COG0784	Response regulator, receiver
BM528_11030	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM528_11055	COG3139	Protein of unknown function (DUF1315)
BM528_11065	COG1115	amino acid carrier protein
BM528_11070	COG2866	Carboxypeptidase
BM528_11090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM528_11100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM528_11105	COG1640	4-alpha-glucanotransferase
BM528_11115	COG0676	glucose-6-phosphate 1-epimerase activity
BM528_11120	COG0800	Aldolase
BM528_11130	COG0129	dihydroxy-acid dehydratase activity
BM528_11140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM528_11145	COG1737	Transcriptional regulator
BM528_11150	COG0469	pyruvate kinase activity
BM528_11210	COG1741	Belongs to the pirin family
BM528_11220	COG1278	Cold shock
BM528_11230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_11235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_11240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM528_11260	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BM528_11265	COG3177	Filamentation induced by cAMP protein fic
BM528_11270	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BM528_11355	COG0471	metal ion transport
BM528_11370	COG0489	protein tyrosine kinase activity
BM528_11375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM528_11375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM528_11380	COG2226	methyltransferase
BM528_11385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_11390	COG1388	LysM domain
BM528_11390	COG0741	lytic transglycosylase activity
BM528_11410	COG0545	Peptidyl-prolyl cis-trans isomerase
BM528_11420	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_11430	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_11455	COG0642	Histidine kinase
BM528_11460	COG0745	RESPONSE REGULATOR receiver
BM528_11470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM528_11475	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM528_11480	COG1785	Belongs to the alkaline phosphatase family
BM528_11485	COG1785	Belongs to the alkaline phosphatase family
BM528_11545	COG1733	regulation of RNA biosynthetic process
BM528_11550	COG0604	alcohol dehydrogenase
BM528_11555	COG0784	Response regulator, receiver
BM528_11555	COG2205	protein histidine kinase activity
BM528_11560	COG0604	alcohol dehydrogenase
BM528_11585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM528_11590	COG1286	toxin biosynthetic process
BM528_11595	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BM528_11600	COG0285	dihydrofolate synthase activity
BM528_11625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM528_11640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM528_11645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM528_11645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM528_11720	COG0789	Transcriptional regulator
BM528_11725	COG4977	sequence-specific DNA binding
BM528_11750	COG2132	Multicopper oxidase
BM528_11755	COG3667	copper resistance
BM528_11895	COG3101	peptidyl-lysine hydroxylation
BM528_11915	COG1620	l-lactate permease
BM528_11925	COG0352	thiamine-phosphate diphosphorylase activity
BM528_11945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM528_11950	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM528_11950	COG1902	pentaerythritol trinitrate reductase activity
BM528_11955	COG1024	Enoyl-CoA hydratase
BM528_11975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BM528_11985	COG4399	Belongs to the UPF0754 family
BM528_12010	COG2186	Transcriptional regulator
BM528_12020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BM528_12025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM528_12030	COG2983	Belongs to the UPF0260 family
BM528_12035	COG0179	Fumarylacetoacetate (FAA) hydrolase
BM528_12050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BM528_12055	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_12070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM528_12075	COG1607	acyl-coa hydrolase
BM528_12110	COG1183	phosphatidylcholine synthase activity
BM528_12130	COG0277	FAD linked oxidase domain protein
BM528_12135	COG0542	response to heat
BM528_12145	COG0564	pseudouridine synthase activity
BM528_12160	COG1595	DNA-templated transcription, initiation
BM528_12175	COG4221	oxidoreductase activity
BM528_12190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BM528_12200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BM528_12210	COG0142	geranyltranstransferase activity
BM528_12220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BM528_12225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM528_12235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM528_12250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM528_12250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM528_12265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM528_12270	COG0488	(ABC) transporter
BM528_12280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM528_12290	COG0560	Phosphoserine phosphatase
BM528_12300	COG0084	hydrolase, TatD family'
BM528_12320	COG0681	Belongs to the peptidase S26 family
BM528_12335	COG3026	antisigma factor binding
BM528_12345	COG1595	DNA-templated transcription, initiation
BM528_12350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM528_12360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BM528_12400	COG4795	General secretion pathway protein
BM528_12440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM528_12445	COG1047	Peptidyl-prolyl cis-trans
BM528_12455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM528_12460	COG0196	riboflavin kinase activity
BM528_12465	COG0728	peptidoglycan biosynthetic process
BM528_12470	COG0268	Binds directly to 16S ribosomal RNA
BM528_12495	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM528_12505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM528_12510	COG0776	regulation of translation
BM528_12515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM528_12520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM528_12525	COG0740	serine-type endopeptidase activity
BM528_12530	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM528_12575	COG1720	tRNA m6t6A37 methyltransferase activity
BM528_12585	COG1234	tRNA 3'-trailer cleavage
BM528_12595	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM528_12615	COG0516	GMP reductase activity
BM528_12615	COG0517	IMP dehydrogenase activity
BM528_12620	COG1570	exodeoxyribonuclease VII activity
BM528_12645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM528_12650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM528_12655	COG2976	Protein conserved in bacteria
BM528_12675	COG3063	Type IV pilus biogenesis stability protein PilW
BM528_12680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM528_12690	COG2166	iron-sulfur cluster assembly
BM528_12700	COG0316	Belongs to the HesB IscA family
BM528_12705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM528_12710	COG0719	Fe-S assembly protein
BM528_12715	COG0396	ATPase activity
BM528_12720	COG0719	Fe-S assembly protein
BM528_12725	COG1104	cysteine desulfurase activity
BM528_12730	COG1959	2 iron, 2 sulfur cluster binding
BM528_12750	COG2072	flavoprotein involved in K transport
BM528_12760	COG1045	serine acetyltransferase
BM528_12765	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM528_12770	COG0483	inositol monophosphate 1-phosphatase activity
BM528_12775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM528_12780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM528_12785	COG1862	Preprotein translocase
BM528_12790	COG0343	queuine tRNA-ribosyltransferase activity
BM528_12810	COG1842	Phage shock protein A
BM528_12815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM528_12835	COG0754	glutathionylspermidine amidase activity
BM528_12850	COG1136	(ABC) transporter
BM528_12865	COG2066	Belongs to the glutaminase family
BM528_12870	COG1785	Belongs to the alkaline phosphatase family
BM528_12990	COG0438	transferase activity, transferring glycosyl groups
BM528_13005	COG0367	asparagine synthase
BM528_13010	COG0438	transferase activity, transferring glycosyl groups
BM528_13040	COG2244	polysaccharide biosynthetic process
BM528_13100	COG0489	protein tyrosine kinase activity
BM528_13110	COG3409	Peptidoglycan-binding domain 1 protein
BM528_13110	COG3267	Type II secretory pathway component ExeA
BM528_13115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM528_13115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM528_13120	COG2827	Endonuclease containing a URI domain
BM528_13140	COG1560	Kdo2-lipid A biosynthetic process
BM528_13170	COG1960	acyl-CoA dehydrogenase activity
BM528_13190	COG1435	thymidine kinase activity
BM528_13195	COG1609	Transcriptional regulator
BM528_13200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM528_13215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM528_13220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM528_13240	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BM528_13275	COG1960	acyl-CoA dehydrogenase activity
BM528_13320	COG4221	oxidoreductase activity
BM528_13325	COG1280	lysine exporter protein (LysE YggA)
BM528_13355	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_13415	COG1629	transport
BM528_13415	COG4771	TonB-dependent receptor
BM528_13420	COG4558	Periplasmic binding protein
BM528_13425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BM528_13430	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BM528_13445	COG2814	Major facilitator Superfamily
BM528_13460	COG4681	YaeQ
BM528_13465	COG0514	ATP-dependent DNA helicase (RecQ)
BM528_13470	COG1295	ribonuclease BN
BM528_13480	COG1476	TRANSCRIPTIONal
BM528_13490	COG2205	protein histidine kinase activity
BM528_13490	COG4999	Histidine kinase
BM528_13490	COG3850	Histidine kinase
BM528_13490	COG3437	response regulator, receiver
BM528_13520	COG2133	pyrroloquinoline quinone binding
BM528_13525	COG0513	Belongs to the DEAD box helicase family
BM528_13545	COG3177	Filamentation induced by cAMP protein fic
BM528_13550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM528_13555	COG1518	maintenance of DNA repeat elements
BM528_13590	COG1203	CRISPR-associated helicase, Cas3
BM528_13660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_13700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM528_13705	COG0583	DNA-binding transcription factor activity
BM528_13715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM528_13720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM528_13725	COG0006	proline dipeptidase activity
BM528_13730	COG3079	Belongs to the UPF0149 family
BM528_13740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM528_13750	COG2205	protein histidine kinase activity
BM528_13750	COG0784	Response regulator, receiver
BM528_13755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM528_13760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM528_13765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM528_13820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_13825	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM528_13830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BM528_13835	COG2186	Transcriptional regulator
BM528_13845	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM528_13850	COG0675	Transposase, IS605 OrfB family
BM528_13855	COG1943	Transposase
BM528_13860	COG3577	Aspartyl protease
BM528_13865	COG0157	Belongs to the NadC ModD family
BM528_13875	COG1459	type II secretion system
BM528_13885	COG0237	dephospho-CoA kinase activity
BM528_13890	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BM528_13900	COG3608	succinylglutamate desuccinylase aspartoacylase
BM528_13905	COG0494	nUDIX hydrolase
BM528_13915	COG0739	heme binding
BM528_13920	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BM528_13925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM528_13930	COG0849	cell division
BM528_13935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BM528_13940	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM528_13955	COG0772	Belongs to the SEDS family
BM528_13970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM528_13975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM528_13980	COG0768	penicillin binding
BM528_13985	COG3116	cell division
BM528_13995	COG2001	Belongs to the MraZ family
BM528_14015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM528_14015	COG0678	peroxiredoxin activity
BM528_14030	COG3706	GGDEF domain
BM528_14045	COG2204	response regulator
BM528_14050	COG5002	protein histidine kinase activity
BM528_14075	COG0668	transmembrane transport
BM528_14085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BM528_14090	COG0189	ligase activity
BM528_14095	COG1678	Uncharacterized ACR, COG1678
BM528_14100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM528_14120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BM528_14125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM528_14130	COG0762	integral membrane protein
BM528_14140	COG1902	pentaerythritol trinitrate reductase activity
BM528_14140	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM528_14185	COG0083	homoserine kinase activity
BM528_14195	COG0583	DNA-binding transcription factor activity
BM528_14210	COG0640	Transcriptional regulator
BM528_14220	COG0431	NADPH-dependent FMN reductase
BM528_14225	COG0798	PFAM Bile acid sodium symporter
BM528_14235	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BM528_14240	COG0745	RESPONSE REGULATOR receiver
BM528_14270	COG1748	Saccharopine dehydrogenase
BM528_14285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM528_14290	COG3107	peptidoglycan biosynthetic process
BM528_14295	COG0792	nuclease activity
BM528_14305	COG2823	Periplasmic or secreted lipoprotein
BM528_14315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM528_14330	COG2212	antiporter activity
BM528_14335	COG1863	multisubunit Na H antiporter MnhE subunit
BM528_14340	COG0651	ATP synthesis coupled electron transport
BM528_14345	COG1006	Multisubunit Na H antiporter MnhC subunit
BM528_14350	COG2111	Na H antiporter
BM528_14350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BM528_14365	COG4771	TonB-dependent receptor
BM528_14375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BM528_14380	COG0372	Belongs to the citrate synthase family
BM528_14385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BM528_14390	COG2828	Protein conserved in bacteria
BM528_14395	COG2199	diguanylate cyclase activity
BM528_14395	COG2203	Gaf domain
BM528_14415	COG5002	protein histidine kinase activity
BM528_14415	COG2198	Histidine kinase
BM528_14415	COG0784	Response regulator, receiver
BM528_14425	COG0067	glutamate synthase
BM528_14425	COG0070	glutamate synthase
BM528_14425	COG0069	glutamate synthase activity
BM528_14430	COG0493	'glutamate synthase
BM528_14440	COG0154	amidase activity
BM528_14450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM528_14460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BM528_14465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_14480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM528_14485	COG0739	heme binding
BM528_14490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM528_14500	COG4572	Cation transport regulator
BM528_14505	COG4555	ABC transporter
BM528_14525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM528_14530	COG0625	glutathione transferase activity
BM528_14540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_14540	COG4191	Histidine kinase
BM528_14545	COG3706	GGDEF domain
BM528_14545	COG2203	Gaf domain
BM528_14545	COG4251	negative regulation of phosphorylation
BM528_14545	COG5001	Diguanylate cyclase
BM528_14555	COG2894	cell division
BM528_14560	COG0850	regulation of cytokinetic process
BM528_14600	COG1914	H( )-stimulated, divalent metal cation uptake system
BM528_14605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BM528_14620	COG0174	glutamine synthetase
BM528_14630	COG3852	Histidine kinase
BM528_14635	COG2204	response regulator
BM528_14640	COG3437	response regulator, receiver
BM528_14645	COG0204	Acyl-transferase
BM528_14670	COG0525	valine-tRNA ligase activity
BM528_14675	COG2927	DNA polymerase III (CHI subunit)
BM528_14680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM528_14685	COG0795	lipopolysaccharide-transporting ATPase activity
BM528_14690	COG0795	lipopolysaccharide-transporting ATPase activity
BM528_14735	COG0738	Major facilitator superfamily
BM528_14755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BM528_14765	COG0464	growth
BM528_14770	COG1404	Belongs to the peptidase S8 family
BM528_14780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_14785	COG0732	type I restriction modification DNA specificity domain
BM528_14790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BM528_14870	COG0425	Belongs to the sulfur carrier protein TusA family
BM528_14870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_14905	COG3268	Saccharopine dehydrogenase
BM528_14910	COG1960	acyl-CoA dehydrogenase activity
BM528_14940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM528_14945	COG3706	GGDEF domain
BM528_14975	COG0277	FAD linked oxidase domain protein
BM528_14985	COG0513	Belongs to the DEAD box helicase family
BM528_14990	COG5001	Diguanylate cyclase
BM528_15005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM528_15005	COG3264	Mechanosensitive ion channel
BM528_15020	COG2202	Pas domain
BM528_15020	COG2200	EAL domain
BM528_15020	COG2199	diguanylate cyclase activity
BM528_15035	COG0583	DNA-binding transcription factor activity
BM528_15040	COG0730	response to heat
BM528_15045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM528_15050	COG0745	RESPONSE REGULATOR receiver
BM528_15060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_15060	COG4191	Histidine kinase
BM528_15120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_15130	COG1573	uracil-dna glycosylase
BM528_15135	COG5001	Diguanylate cyclase
BM528_15135	COG3300	MHYT domain
BM528_15155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM528_15180	COG1842	Phage shock protein A
BM528_15190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM528_15200	COG3550	peptidyl-serine autophosphorylation
BM528_15220	COG0204	Acyl-transferase
BM528_15225	COG0204	Acyl-transferase
BM528_15230	COG0668	transmembrane transport
BM528_15245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM528_15250	COG0733	neurotransmitter:sodium symporter activity
BM528_15265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM528_15280	COG0716	FMN binding
BM528_15290	COG0848	biopolymer transport protein
BM528_15300	COG0457	Tetratricopeptide repeat
BM528_15305	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BM528_15330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BM528_15350	COG5002	protein histidine kinase activity
BM528_15350	COG5001	Diguanylate cyclase
BM528_15360	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BM528_15370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_15380	COG0583	DNA-binding transcription factor activity
BM528_15385	COG0121	glutamine amidotransferase
BM528_15410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_15420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BM528_15430	COG1477	protein flavinylation
BM528_15435	COG2871	sodium ion transport
BM528_15440	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM528_15445	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM528_15450	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM528_15455	COG1805	sodium ion transport
BM528_15465	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM528_15470	COG0545	Peptidyl-prolyl cis-trans isomerase
BM528_15475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM528_15485	COG0039	L-malate dehydrogenase activity
BM528_15490	COG1438	arginine binding
BM528_15515	COG0572	uridine kinase
BM528_15520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM528_15535	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM528_15540	COG0745	RESPONSE REGULATOR receiver
BM528_15540	COG3706	GGDEF domain
BM528_15550	COG0517	IMP dehydrogenase activity
BM528_15550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BM528_15555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_15565	COG5002	protein histidine kinase activity
BM528_15575	COG0189	ligase activity
BM528_15585	COG0189	ligase activity
BM528_15585	COG4067	protein conserved in archaea
BM528_15610	COG1283	sodium-dependent phosphate transmembrane transporter activity
BM528_15615	COG0667	Aldo Keto reductase
BM528_15625	COG5001	Diguanylate cyclase
BM528_15725	COG1484	DNA-dependent DNA replication
BM528_15730	COG4584	PFAM Integrase catalytic
BM528_15760	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BM528_15770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BM528_15815	COG0583	DNA-binding transcription factor activity
BM528_15830	COG2963	transposase activity
BM528_15835	COG2963	transposase activity
BM528_15850	COG1215	transferase activity, transferring glycosyl groups
BM528_15895	COG0662	Cupin 2, conserved barrel domain protein
BM528_15895	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BM528_15920	COG3706	GGDEF domain
BM528_15930	COG0202	RNA polymerase activity
BM528_15950	COG0201	protein transport
BM528_15955	COG0200	Binds to the 23S rRNA
BM528_15970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BM528_16025	COG0557	exoribonuclease II activity
BM528_16040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BM528_16060	COG2234	aminopeptidase activity
BM528_16070	COG4251	negative regulation of phosphorylation
BM528_16085	COG1271	oxidase subunit
BM528_16090	COG1294	oxidase, subunit
BM528_16095	COG1522	sequence-specific DNA binding
BM528_16105	COG1278	Cold shock
BM528_16110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM528_16130	COG0339	signal peptide processing
BM528_16135	COG2201	protein-glutamate methylesterase activity
BM528_16145	COG4191	Histidine kinase
BM528_16145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_16155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_16165	COG1506	peptidase
BM528_16165	COG4946	Tricorn protease homolog
BM528_16165	COG0823	Involved in the tonB-independent uptake of proteins
BM528_16220	COG2197	response regulator
BM528_16230	COG0189	ligase activity
BM528_16240	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BM528_16245	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM528_16250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM528_16265	COG0281	malic enzyme
BM528_16275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BM528_16305	COG0456	acetyltransferase
BM528_16315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM528_16320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM528_16325	COG2177	Part of the ABC transporter FtsEX involved in
BM528_16330	COG2884	Cell division ATP-binding protein ftsE
BM528_16335	COG0552	protein localization to endoplasmic reticulum
BM528_16340	COG0742	ribosomal rna small subunit methyltransferase
BM528_16345	COG3068	Protein conserved in bacteria
BM528_16350	COG2095	MarC family integral membrane protein
BM528_16370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM528_16375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM528_16385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM528_16400	COG0076	glutamate decarboxylase activity
BM528_16415	COG0842	Transport permease protein
BM528_16420	COG1131	(ABC) transporter
BM528_16425	COG4774	siderophore transport
BM528_16435	COG1253	flavin adenine dinucleotide binding
BM528_16445	COG1966	Carbon starvation protein
BM528_16475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM528_16480	COG0049	tRNA binding
BM528_16485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BM528_16490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM528_16495	COG0085	RNA polymerase activity
BM528_16500	COG0222	ribosome binding
BM528_16505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM528_16510	COG0081	regulation of translation
BM528_16515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM528_16520	COG3706	GGDEF domain
BM528_16530	COG0250	Participates in transcription elongation, termination and antitermination
BM528_16535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM528_16545	COG1132	(ABC) transporter
BM528_16560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM528_16565	COG3590	peptidase
BM528_16575	COG0513	Belongs to the DEAD box helicase family
BM528_16580	COG0418	dihydroorotase activity
BM528_16590	COG3040	lipid binding
BM528_16595	COG4989	oxidoreductase activity
BM528_16600	COG0346	lactoylglutathione lyase activity
BM528_16620	COG0302	gtp cyclohydrolase
BM528_16630	COG2957	Belongs to the agmatine deiminase family
BM528_16635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM528_16645	COG1201	RNA secondary structure unwinding
BM528_16665	COG1793	dna ligase
BM528_16685	COG0625	glutathione transferase activity
BM528_16695	COG5380	lipid catabolic process
BM528_16700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BM528_16715	COG1012	belongs to the aldehyde dehydrogenase family
BM528_16720	COG0028	Belongs to the TPP enzyme family
BM528_16730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM528_16735	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BM528_16740	COG0330	HflC and HflK could
BM528_16745	COG0330	HflC and HflK could
BM528_16750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM528_16755	COG1923	regulation of RNA biosynthetic process
BM528_16760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM528_16775	COG0802	atpase or kinase
BM528_16780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM528_16780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM528_16795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BM528_16800	COG2816	NAD+ diphosphatase activity
BM528_16805	COG0735	belongs to the Fur family
BM528_16815	COG0432	Pfam Uncharacterised protein family UPF0047
BM528_16825	COG0305	Participates in initiation and elongation during chromosome replication
BM528_16850	COG2258	MOSC domain
BM528_16875	COG5002	protein histidine kinase activity
BM528_16885	COG1136	(ABC) transporter
BM528_16895	COG0840	transmembrane signaling receptor activity
BM528_16900	COG5002	protein histidine kinase activity
BM528_16930	COG4774	siderophore transport
BM528_16935	COG1472	Belongs to the glycosyl hydrolase 3 family
BM528_16945	COG2723	6-phospho-beta-galactosidase activity
BM528_16950	COG1609	Transcriptional regulator
BM528_16955	COG2814	Major facilitator Superfamily
BM528_16955	COG0477	Major facilitator Superfamily
BM528_16960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM528_16965	COG4988	ABC transporter
BM528_16970	COG4890	Cyd operon protein YbgT
BM528_16975	COG1294	oxidase, subunit
BM528_16990	COG2204	response regulator
BM528_17005	COG2375	cellular response to nickel ion
BM528_17025	COG2267	carboxylic ester hydrolase activity
BM528_17035	COG3038	cytochrome b561
BM528_17040	COG2353	YceI-like domain
BM528_17045	COG1252	NADH dehydrogenase
BM528_17065	COG2067	long-chain fatty acid transport protein
BM528_17070	COG2203	Gaf domain
BM528_17070	COG3706	GGDEF domain
BM528_17070	COG4251	negative regulation of phosphorylation
BM528_17070	COG5001	Diguanylate cyclase
BM528_17085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM528_17095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM528_17105	COG0673	inositol 2-dehydrogenase activity
BM528_17120	COG0697	spore germination
BM528_17125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BM528_17130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BM528_17140	COG1166	arginine decarboxylase activity
BM528_17150	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BM528_17155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM528_17160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM528_17170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM528_17195	COG4232	protein-disulfide reductase activity
BM528_17205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM528_17210	COG0511	ligase activity, forming carbon-carbon bonds
BM528_17215	COG0439	Biotin carboxylase
BM528_17230	COG2176	DNA-directed DNA polymerase activity
BM528_17255	COG0154	amidase activity
BM528_17270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM528_17275	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BM528_17295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM528_17315	COG3093	addiction module antidote protein HigA
BM528_17350	COG3954	Phosphoribulokinase
BM528_17360	COG0745	RESPONSE REGULATOR receiver
BM528_17370	COG1501	Belongs to the glycosyl hydrolase 31 family
BM528_17380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM528_17390	COG3031	protein transport across the cell outer membrane
BM528_17400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM528_17405	COG1459	type II secretion system
BM528_17410	COG2165	general secretion pathway protein
BM528_17415	COG2165	general secretion pathway protein
BM528_17420	COG2165	general secretion pathway protein
BM528_17425	COG4795	General secretion pathway protein
BM528_17430	COG3156	type II secretion system protein K
BM528_17440	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BM528_17460	COG1012	belongs to the aldehyde dehydrogenase family
BM528_17470	COG1011	Hydrolase
BM528_17475	COG0494	nUDIX hydrolase
BM528_17480	COG1218	3'(2'),5'-bisphosphate nucleotidase
BM528_17495	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BM528_17505	COG3089	Belongs to the UPF0270 family
BM528_17510	COG0429	hydrolase of the alpha beta-hydrolase fold
BM528_17520	COG0488	(ABC) transporter
BM528_17530	COG2900	Belongs to the SlyX family
BM528_17540	COG0545	Peptidyl-prolyl cis-trans isomerase
BM528_17555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM528_17560	COG2183	response to ionizing radiation
BM528_17575	COG0596	Alpha beta hydrolase
BM528_17580	COG1040	competence protein
BM528_17600	COG1794	racemase activity, acting on amino acids and derivatives
BM528_17610	COG0534	Mate efflux family protein
BM528_17625	COG1999	signal sequence binding
BM528_17630	COG0109	protoheme IX farnesyltransferase activity
BM528_17635	COG1612	heme a metabolic process
BM528_17665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM528_17670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BM528_17700	COG0129	dihydroxy-acid dehydratase activity
BM528_17705	COG2860	membrane
BM528_17710	COG0606	chelatase, subunit chli
BM528_17715	COG0583	DNA-binding transcription factor activity
BM528_17725	COG2814	Major facilitator Superfamily
BM528_17735	COG0729	surface antigen
BM528_17740	COG2911	Protein conserved in bacteria
BM528_17750	COG1595	DNA-templated transcription, initiation
BM528_17765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM528_17775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM528_17795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM528_17820	COG1228	amidohydrolase
BM528_17835	COG0425	Belongs to the sulfur carrier protein TusA family
BM528_17850	COG1561	YicC-like family, N-terminal region
BM528_17955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM528_17975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM528_17980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM528_18000	COG1475	DNA binding
BM528_18005	COG1192	Involved in chromosome partitioning
BM528_18030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM528_18035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM528_18045	COG0706	membrane insertase activity
BM528_18050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BM528_18055	COG0230	Belongs to the bacterial ribosomal protein bL34 family