locus-tag class description AOR13_1004 ENOG4105F9F transposase AOR13_1009 ENOG4105ENX hydrolase AOR13_101 ENOG4105CUY Mechanosensitive ion channel AOR13_1010 ENOG4105CF7 AraC family transcriptional regulator AOR13_1017 ENOG4108BPE -transporting atpase AOR13_102 ENOG4106HNH Acyl-transferase AOR13_1024 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AOR13_1029 ENOG4105MP9 class II Aldolase AOR13_103 ENOG4106HNH Acyl-transferase AOR13_1030 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AOR13_1034 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOR13_1035 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AOR13_1036 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AOR13_1037 ENOG4108S3P Sporulation domain protein AOR13_1038 ENOG4105E96 Colicin v production protein AOR13_1039 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AOR13_104 ENOG4105C4W S-formylglutathione hydrolase AOR13_1041 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AOR13_1042 ENOG4108ZYK Acyl carrier protein phosphodiesterase AOR13_1043 ENOG4105EY3 heparinase II III family protein AOR13_1044 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AOR13_1045 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding AOR13_1046 ENOG4105C7W Xanthine dehydrogenase AOR13_1047 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOR13_105 ENOG4105BZU Histidine kinase AOR13_1051 ENOG4107S78 Band 7 protein AOR13_1054 ENOG4105G6Z alkaline phosphatase AOR13_1055 ENOG4105G6Z alkaline phosphatase AOR13_1057 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AOR13_1058 ENOG4105C8N cysteinyl-tRNA synthetase AOR13_1061 ENOG4105E9H Lytic Murein transglycosylase AOR13_1062 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOR13_1063 ENOG4105D1A Methyltransferase AOR13_1064 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOR13_1065 ENOG4105D1F ATP-binding protein AOR13_1066 ENOG4105DHP deoxycytidine triphosphate deaminase AOR13_1067 ENOG4105C8P )-transporter AOR13_1071 ENOG4108RCM Nitroreductase AOR13_1078 ENOG4105CH6 catalase AOR13_1080 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_1085 ENOG4107RF4 Phosphodiesterase AOR13_1086 ENOG4106DTQ Protein TsgA homolog AOR13_1087 ENOG4105DU0 nucleoside hydrolase AOR13_1088 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AOR13_1093 ENOG4105BZU Histidine kinase AOR13_1094 ENOG4105E3W Two component transcriptional regulator (Winged helix family AOR13_1096 ENOG4105BZU Histidine kinase AOR13_1098 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOR13_110 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOR13_1100 ENOG4108Z9K Osmotically inducible protein AOR13_1103 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AOR13_1107 ENOG4105BZU Histidine kinase AOR13_1110 ENOG4105CK5 oxidoreductase AOR13_1111 ENOG4105CXK mandelate racemase muconate lactonizing AOR13_1119 ENOG4108K8S endonuclease I AOR13_112 ENOG41087YS Phage shock protein A AOR13_1122 ENOG4105BZU Histidine kinase AOR13_1123 ENOG4105NBR Pectinesterase AOR13_1125 ENOG4107XII Glycosyl Hydrolase Family 88 AOR13_1127 ENOG4107TDE lipolytic protein G-D-S-L family AOR13_1128 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AOR13_1129 ENOG4105DEI Mannitol dehydrogenase AOR13_1130 ENOG4105D2H Uronic isomerase AOR13_1131 ENOG4105CTX dehydratase AOR13_1133 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AOR13_1135 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AOR13_1136 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) AOR13_1137 ENOG4105CHR reductase AOR13_1140 ENOG4105EIG urea carboxylase-associated protein 1 AOR13_1145 ENOG4105E3W Two component transcriptional regulator (Winged helix family AOR13_1146 ENOG4105EB3 Histidine kinase AOR13_1154 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AOR13_1156 ENOG4105CA9 Pyruvate kinase AOR13_1157 ENOG4106KNT transcriptional regulator AOR13_1158 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOR13_1159 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) AOR13_1160 ENOG4105C01 Dihydroxy-acid dehydratase AOR13_1161 ENOG4105CHC glucokinase (EC 2.7.1.2) AOR13_1162 ENOG4108UHU Aldolase AOR13_1163 ENOG4105DSB aldose 1-epimerase AOR13_1165 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AOR13_1166 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AOR13_1168 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AOR13_1169 ENOG4105E0X reductase AOR13_117 ENOG4107ZSV Receptor AOR13_1175 ENOG4105BZG amino acid carrier protein AOR13_1177 ENOG4105VUT cytoplasmic protein AOR13_118 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AOR13_1182 ENOG4105DK2 UPF0207 protein AOR13_1187 ENOG4105BZU Histidine kinase AOR13_119 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AOR13_1191 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_1193 ENOG4107RSM transcriptional regulator AOR13_1195 ENOG41082SX arsR family transcriptional regulator AOR13_1199 ENOG4105CVI Transcriptional regulator AOR13_120 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AOR13_1202 ENOG4108YXG UPF0502 protein AOR13_1204 ENOG4105BZU Histidine kinase AOR13_1205 ENOG4108IQE Amp-dependent synthetase and ligase AOR13_1207 ENOG4105DSY exodeoxyribonuclease V, gamma AOR13_1208 ENOG4107QKA exodeoxyribonuclease V beta AOR13_1209 ENOG4107QYX exodeoxyribonuclease v alpha AOR13_1212 ENOG4105CIH Imidazole acetol-phosphate transaminase AOR13_1216 ENOG4105EG6 Saccharopine dehydrogenase AOR13_1217 ENOG4105CHM Aminotransferase AOR13_1219 ENOG4105BZU Histidine kinase AOR13_122 ENOG4105BZU Histidine kinase AOR13_1224 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AOR13_123 ENOG4108RG0 uracil-dna glycosylase AOR13_125 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AOR13_1260 ENOG4105D06 uba thif-type nad fad binding protein AOR13_1261 ENOG4108RIR Molybdenum cofactor biosynthesis protein AOR13_1262 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOR13_1263 ENOG4105M00 molybdopterin converting factor, subunit 1 AOR13_1264 ENOG4108ZAF Molybdopterin AOR13_1265 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOR13_1266 ENOG4105E0C molybdate abc transporter AOR13_1267 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AOR13_1268 ENOG4105D4P Coproporphyrinogen iii oxidase AOR13_1274 ENOG4105C1G acyl-Coa dehydrogenase AOR13_1280 ENOG4108J2P Alpha beta hydrolase fold AOR13_1281 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOR13_1282 ENOG4105CHU acetyl-coa acetyltransferase AOR13_1283 ENOG4105CSU acyl-Coa dehydrogenase AOR13_1284 ENOG4105D74 hydrolase AOR13_1286 ENOG4105DKT Transcriptional regulator AOR13_1287 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AOR13_1289 ENOG4105DEI Mannitol dehydrogenase AOR13_129 ENOG4105EJ2 Transcriptional regulator AOR13_1294 ENOG4105D64 Mechanosensitive ion channel AOR13_1299 ENOG4105D8X mechanosensitive ion channel AOR13_13 ENOG4105CH6 catalase AOR13_130 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AOR13_1300 ENOG4105D05 Receptor AOR13_1301 ENOG4105KZX Pterin carbinolamine dehydratase AOR13_1304 ENOG4105BZU Histidine kinase AOR13_1305 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOR13_1306 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AOR13_1307 ENOG4105CHV Transcription elongation factor NusA AOR13_1308 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AOR13_1309 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AOR13_1310 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AOR13_1311 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AOR13_1312 ENOG4108M3P Membrane AOR13_1314 ENOG4105BZU Histidine kinase AOR13_1315 ENOG4107R6F Alpha Beta Hydrolase Fold protein AOR13_1317 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AOR13_1322 ENOG4105D3R alkyl hydroperoxide reductase AOR13_1328 ENOG4105D05 Receptor AOR13_1331 ENOG4105VNH ABC transporter solute-binding protein AOR13_1332 ENOG4105CXZ ABC transporter, permease AOR13_1333 ENOG4108VGW abc transporter atp-binding protein AOR13_1334 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AOR13_1341 ENOG4105BZU Histidine kinase AOR13_1346 ENOG4105CBN LysR family transcriptional regulator AOR13_1347 ENOG4105E0K tonB-dependent siderophore receptor AOR13_1352 ENOG4105GFR rna polymerase sigma factor AOR13_1354 ENOG4105C26 Dehydrogenase AOR13_1355 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AOR13_1360 ENOG4105F27 Major Facilitator AOR13_1361 ENOG4105D05 Receptor AOR13_1364 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AOR13_1365 ENOG4108Z1B Cyclase dehydrase AOR13_1366 ENOG4105VDB UPF0125 protein AOR13_1368 ENOG4105C94 Transporter AOR13_1370 ENOG4107RDJ Sulfotransferase AOR13_1375 ENOG4107UWP Major facilitator superfamily MFS_1 AOR13_1380 ENOG4107ZT6 cytidine deaminase AOR13_1384 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AOR13_1385 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AOR13_1386 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AOR13_1389 ENOG4105BZ1 (ABC) transporter AOR13_139 ENOG4105CQ2 DNA polymerase AOR13_1390 ENOG4105W49 UPF0434 protein AOR13_1391 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AOR13_1392 ENOG4105CHR reductase AOR13_1393 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AOR13_1397 ENOG4105CUZ uba thif-type nad fad binding protein AOR13_1398 ENOG4105D5U fad dependent oxidoreductase AOR13_1399 ENOG4105CHF Glutathione S-transferase AOR13_1400 ENOG4107QKV phosphomannomutase AOR13_1402 ENOG4105BZN citrate synthase AOR13_1403 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AOR13_1404 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AOR13_1405 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AOR13_1406 ENOG4105E33 succinate dehydrogenase AOR13_1407 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AOR13_1408 ENOG4105C7S Dehydrogenase AOR13_1409 ENOG4105CMV Succinyl-CoA synthetase subunit beta AOR13_141 ENOG4105BZU Histidine kinase AOR13_1410 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AOR13_1413 ENOG4105QV4 Tryptophan halogenase AOR13_1416 ENOG4108NRW Phospholipase, patatin family AOR13_142 ENOG4105CIH Imidazole acetol-phosphate transaminase AOR13_1420 ENOG4108IUK alpha amylase, catalytic AOR13_1423 ENOG4105ETE Transcriptional regulator (LacI family AOR13_1425 ENOG4105CX6 glutaminyL-tRNA synthetase AOR13_1426 ENOG4105UBK short-chain dehydrogenase reductase AOR13_1427 ENOG4108M0H Extracellular lipase AOR13_1428 ENOG4107SQI penicillin amidase AOR13_1429 ENOG4105ERU peptidase AOR13_143 ENOG4105HF0 Membrane AOR13_1435 ENOG4107QNR UPF0135 protein AOR13_1436 ENOG4106371 Methyltransferase AOR13_1437 ENOG4105C5I Dehydrogenase AOR13_1438 ENOG4108V06 Glutathione peroxidase AOR13_1439 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AOR13_1441 ENOG4105C1G acyl-Coa dehydrogenase AOR13_1442 ENOG4108UKI Enoyl-CoA hydratase AOR13_1443 ENOG4105DHI Methyltransferase AOR13_1445 ENOG4105E68 Sulfatase AOR13_1446 ENOG4105PAN UPF0352 protein AOR13_1447 ENOG4106V8H Nucleoid-associated protein AOR13_1453 ENOG4108HRK Histidine kinase AOR13_1454 ENOG4108NEV two component transcriptional regulator, LytTR family AOR13_1455 ENOG4105CTQ phosphohexokinase AOR13_1457 ENOG4105BZU Histidine kinase AOR13_1460 ENOG4105C72 UPF0176 protein AOR13_1462 ENOG4105FE9 pseudouridine synthase AOR13_1477 ENOG4108J1Q AOR13_148 ENOG4105CKD glutathione-regulated potassium-efflux system protein AOR13_1480 ENOG4105C1J atp-dependent rna helicase AOR13_1481 ENOG4107QNJ CoA-transferase subunit B AOR13_1482 ENOG4105D6N CoA-transferase, subunit a AOR13_1483 ENOG4105F04 LysR family Transcriptional regulator AOR13_1486 ENOG4107R11 Transcriptional regulator AOR13_1487 ENOG4105EJQ L-serine dehydratase AOR13_1488 ENOG4105P8F nudix hydrolase AOR13_1489 ENOG4105CRQ synthase (Component I) AOR13_1491 ENOG4105CGY Dna recombination protein AOR13_1492 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AOR13_1494 ENOG4105CPP Dehydrogenase, E1 component AOR13_1495 ENOG4105C7S Dehydrogenase AOR13_1496 ENOG4105D6S protein involved in catabolism of external DNA AOR13_1498 ENOG4105C29 acyl-CoA thioesterase AOR13_1499 ENOG4108Z0R Transferase AOR13_1500 ENOG4105C5R Aminotransferase AOR13_1504 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AOR13_1505 ENOG4105CN1 protease AOR13_1506 ENOG4105C8J )-transporter AOR13_1507 ENOG4105DFD Na H antiporter AOR13_1508 ENOG4105CD8 aminopeptidase N AOR13_151 ENOG4105EGS Mechanosensitive ion channel AOR13_1511 ENOG4105D25 secreted protein AOR13_1514 ENOG4105C7I Dehydrogenase AOR13_1515 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AOR13_1516 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AOR13_1518 ENOG4105C5H ABC transporter AOR13_152 ENOG4107YCY Transcriptional regulator AOR13_1520 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) AOR13_1521 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AOR13_1523 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOR13_1524 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOR13_1525 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AOR13_153 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AOR13_1531 ENOG41080IJ Diacylglycerol kinase AOR13_1532 ENOG41081QV Universal stress protein AOR13_1534 ENOG4105CBC glutamate synthase AOR13_1539 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AOR13_154 ENOG4108UHU Aldolase AOR13_1542 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) AOR13_1547 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AOR13_1548 ENOG4105Q9Y Universal stress protein AOR13_1549 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AOR13_155 ENOG4105C1J atp-dependent rna helicase AOR13_1550 ENOG4105D78 K07001 NTE family protein AOR13_1555 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AOR13_1556 ENOG4105KHC sulfurtransferase AOR13_1557 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AOR13_1558 ENOG4106IUH DTW domain containing protein AOR13_156 ENOG4105IDI abc transporter atp-binding protein AOR13_1574 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AOR13_1575 ENOG4105WH1 Two component transcriptional regulator luxr family AOR13_1576 ENOG4105C2I pirin domain protein AOR13_1583 ENOG4105DHQ Histidine kinase AOR13_1584 ENOG4105XJC Two component transcriptional regulator (Winged helix family AOR13_1589 ENOG4108MN8 Membrane AOR13_1591 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AOR13_1592 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AOR13_1594 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AOR13_1595 ENOG4108KP7 hydrolase AOR13_1596 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AOR13_1597 ENOG4105WMR Protein CrcB homolog AOR13_1598 ENOG4105D1H recombination factor protein RarA AOR13_1599 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AOR13_16 ENOG4105CPC Aldo Keto reductase AOR13_1600 ENOG4105CNU cell division protein FtsK AOR13_1601 ENOG4105EW9 transcriptional regulator AsnC family AOR13_1602 ENOG4105DCF alanine dehydrogenase AOR13_1603 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AOR13_1604 ENOG4105CFV Tetratricopeptide repeat protein AOR13_1605 ENOG4105Q4A inner membrane protein yciS AOR13_1607 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AOR13_1608 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AOR13_1609 ENOG4105CAT Cytidine monophosphate kinase AOR13_1610 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AOR13_1611 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AOR13_1612 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOR13_1614 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOR13_1615 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOR13_1616 ENOG4105XPH Ferredoxin AOR13_1617 ENOG4105BZU Histidine kinase AOR13_1638 ENOG4105CJ1 ABC, transporter AOR13_1641 ENOG4105E0K tonB-dependent siderophore receptor AOR13_1645 ENOG4105C8V SAICAR synthetase AOR13_1646 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AOR13_1647 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOR13_1649 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOR13_1651 ENOG4105ERG peptidase m48, ste24p AOR13_1653 ENOG4105K89 arsenate reductase AOR13_1654 ENOG4105CS1 NAD(P)H quinone oxidoreductase AOR13_1659 ENOG4105CXB phosphoribosylaminoimidazole synthetase AOR13_166 ENOG4105Q36 FHA domain containing protein AOR13_1660 ENOG4108V3E phosphoribosylglycinamide formyltransferase AOR13_1663 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AOR13_1664 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AOR13_1666 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase AOR13_1667 ENOG4105C3Q Glycosyl transferase, family 2 AOR13_1669 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOR13_1673 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOR13_1674 ENOG4105C6T cysteine synthase AOR13_1676 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AOR13_1677 ENOG4108UKI Enoyl-CoA hydratase AOR13_1680 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOR13_1682 ENOG4105C28 cystathionine AOR13_1685 ENOG4105CGF Aromatic amino acid aminotransferase AOR13_1686 ENOG4108UPT UPF0178 protein AOR13_1687 ENOG4105CHR reductase AOR13_1689 ENOG4105CSU acyl-Coa dehydrogenase AOR13_1695 ENOG4105C10 Electron transfer flavoprotein AOR13_1696 ENOG4105BZJ Electron transfer flavoprotein AOR13_1697 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AOR13_1698 ENOG4108YX2 DNA-binding protein AOR13_1699 ENOG4105EV9 Alpha Beta Hydrolase AOR13_170 ENOG4105DPW Major facilitator superfamily MFS_1 AOR13_1701 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AOR13_1702 ENOG4108NVR Methyl-accepting chemotaxis AOR13_1703 ENOG41090R7 Ferric uptake AOR13_1704 ENOG4105C6Z Gluconate AOR13_1705 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AOR13_1706 ENOG4105K2J Transcriptional regulator AOR13_171 ENOG4105M5J Cupin 2, conserved barrel domain protein AOR13_1710 ENOG4105E7W lamb ycsf family protein AOR13_1711 ENOG4108UKZ OsmC family AOR13_1712 ENOG4105ENT Efflux transporter rnd family, mfp subunit AOR13_1717 ENOG4105CHM Aminotransferase AOR13_1718 ENOG4105DK2 UPF0207 protein AOR13_1719 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AOR13_172 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AOR13_1721 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AOR13_1722 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AOR13_1726 ENOG4105K5B UPF0225 protein AOR13_1733 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AOR13_1735 ENOG4105I4A GCN5-related N-acetyltransferase AOR13_1736 ENOG4105DKW ABC transporter AOR13_1738 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AOR13_1742 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AOR13_1744 ENOG4105CK7 Sodium proline symporter AOR13_1748 ENOG4107TE5 Lipid kinase AOR13_1751 ENOG4105BZU Histidine kinase AOR13_1754 ENOG4105CP7 Triose-phosphate isomerase AOR13_1755 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AOR13_1756 ENOG4105EEI dihydropteroate synthase AOR13_1757 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOR13_1758 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AOR13_1760 ENOG4105DAN ATP-dependent protease AOR13_1761 ENOG4105C8T Leucyl-tRNA synthetase AOR13_1763 ENOG4105DJF DNA polymerase III, delta' subunit AOR13_1764 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AOR13_1765 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AOR13_1766 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AOR13_1767 ENOG4105CJN penicillin-binding protein AOR13_1768 ENOG4105CNI cell division protein FtsW AOR13_1769 ENOG4105K6T rare lipoprotein A AOR13_1770 ENOG4105DZ1 carboxypeptidase AOR13_1771 ENOG4108Z43 UPF0250 protein AOR13_1772 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AOR13_1773 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AOR13_1775 ENOG4105HDK L-asparaginase AOR13_1778 ENOG41069NU Nitroreductase AOR13_1781 ENOG4105D07 Signal peptide peptidase, SppA AOR13_1782 ENOG4105GPY SprT protein AOR13_1783 ENOG4105PQ6 UPF0208 membrane protein AOR13_1784 ENOG4105C3M thioredoxin reductase AOR13_1785 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AOR13_1786 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AOR13_1787 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AOR13_1789 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOR13_179 ENOG4105CA0 peroxidase AOR13_1790 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AOR13_1791 ENOG4105VEQ Cold shock protein AOR13_1792 ENOG4105E9K Isocitrate dehydrogenase AOR13_1793 ENOG4108R99 pseudouridine synthase AOR13_1795 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AOR13_1796 ENOG41075W9 High frequency lysogenization protein HflD homolog AOR13_1797 ENOG4107QTF adenylosuccinate lyase AOR13_1799 ENOG4105EZE Cupin 4 family protein AOR13_18 ENOG4105E54 alpha-amylase AOR13_180 ENOG4105PE1 Receptor AOR13_1802 ENOG4105CQB FAD linked oxidase domain protein AOR13_1803 ENOG4105NBK UPF0345 protein AOR13_1804 ENOG4105FQP Beta-lactamase AOR13_1816 ENOG4105DFF Rod shape-determining protein mreb AOR13_1820 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AOR13_1822 ENOG4105CHR reductase AOR13_1826 ENOG4108N2Y auxin Efflux AOR13_1830 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AOR13_1831 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AOR13_1834 ENOG4108V5Q transglutaminase-like protein AOR13_1838 ENOG4105VQU rdd domain containing protein AOR13_1842 ENOG4105BZU Histidine kinase AOR13_1846 ENOG4105F8V Hydrolase, tatD family AOR13_1847 ENOG4107QRG dna polymerase iii AOR13_1848 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AOR13_1849 ENOG4105HHA aminodeoxychorismate lyase AOR13_1850 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AOR13_1851 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AOR13_1852 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AOR13_1853 ENOG4105CHR reductase AOR13_1854 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AOR13_1855 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOR13_1856 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AOR13_1857 ENOG4105VGS 50s ribosomal protein l32 AOR13_1858 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AOR13_1859 ENOG4108UHJ MAF-like protein AOR13_186 ENOG4105BZU Histidine kinase AOR13_1860 ENOG4107XGZ Hydrolase AOR13_1861 ENOG4105EI2 Pseudouridine synthase AOR13_1862 ENOG4105C03 ribonuclease AOR13_1866 ENOG4107YB6 acetyltransferase, (GNAT) family AOR13_1869 ENOG4105EXG Transcriptional regulator AOR13_187 ENOG4105WH1 Two component transcriptional regulator luxr family AOR13_1874 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AOR13_1876 ENOG4108NUU Transcriptional regulator AOR13_1878 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AOR13_1879 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) AOR13_188 ENOG4105C26 Dehydrogenase AOR13_1882 ENOG4105D60 lipoprotein releasing system transmembrane protein AOR13_1883 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOR13_1884 ENOG4108M8H domain protein AOR13_1890 ENOG4108JDX DNA polymerase iii, epsilon subunit AOR13_1891 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AOR13_1893 ENOG4105DR4 Methyltransferase AOR13_1897 ENOG4105CQ7 ATP-dependent helicase AOR13_1905 ENOG4105BZU Histidine kinase AOR13_1906 ENOG4105CJB Exodeoxyribonuclease I AOR13_1908 ENOG4105BZU Histidine kinase AOR13_1909 ENOG4105CHU acetyl-coa acetyltransferase AOR13_191 ENOG4105BZU Histidine kinase AOR13_1910 ENOG4108Z6Z Transcriptional regulator AOR13_1911 ENOG4105C1G acyl-Coa dehydrogenase AOR13_1912 ENOG4107QX3 carboxylase AOR13_1913 ENOG4105CGU Enoyl-CoA hydratase AOR13_1915 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AOR13_1917 ENOG4105BZU Histidine kinase AOR13_1920 ENOG4105DU0 nucleoside hydrolase AOR13_1921 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AOR13_1923 ENOG4105DNH Major Facilitator AOR13_1930 ENOG4105CGK Exodeoxyribonuclease III AOR13_1933 ENOG4105D60 lipoprotein releasing system transmembrane protein AOR13_1935 ENOG4108JA2 transcriptioN-repair coupling factor AOR13_1937 ENOG4108WBT adenosyltransferase AOR13_1938 ENOG4105C8P )-transporter AOR13_1939 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AOR13_1941 ENOG4108Z66 YbaK ebsC protein AOR13_1943 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AOR13_1944 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AOR13_1945 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AOR13_1952 ENOG4105PSV Polysaccharide Biosynthesis Protein AOR13_1954 ENOG4108SHN Glycosyl transferase, family 2 AOR13_1957 ENOG4105CG5 Glycosyl transferase (Group 1 AOR13_1959 ENOG4105BZU Histidine kinase AOR13_1964 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AOR13_1965 ENOG4108QV3 biosynthesis protein AOR13_1966 ENOG4105DAY polysaccharide export protein AOR13_1968 ENOG4105D3Q Sugar transferase AOR13_197 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AOR13_1970 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AOR13_1971 ENOG41082NX 50s ribosomal protein l35 AOR13_1972 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AOR13_1973 ENOG4105C22 threonyL-tRNA synthetase AOR13_1975 ENOG410642E Short chain dehydrogenase AOR13_198 ENOG4106URE pyrroloquinoline quinone biosynthesis protein d AOR13_1982 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AOR13_1983 ENOG4105HF0 Membrane AOR13_1984 ENOG4105C5R Aminotransferase AOR13_1987 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AOR13_1988 ENOG4105C2W permease AOR13_199 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) AOR13_1991 ENOG4105BZU Histidine kinase AOR13_1992 ENOG4105BZU Histidine kinase AOR13_1993 ENOG4105BZU Histidine kinase AOR13_1995 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AOR13_1996 ENOG4105C7N Xanthine uracil vitamin C permease AOR13_1999 ENOG4108R86 Transcriptional regulator AOR13_2 ENOG4105D4A Cell wall formation (By similarity) AOR13_20 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOR13_200 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) AOR13_2001 ENOG4105C7W Xanthine dehydrogenase AOR13_2005 ENOG4107QUY Guanine deaminase AOR13_2007 ENOG4105BZU Histidine kinase AOR13_201 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AOR13_2011 ENOG4105BZU Histidine kinase AOR13_2014 ENOG4105F1J Homogentisate 1,2-dioxygenase AOR13_2018 ENOG4107RBJ symporter AOR13_2019 ENOG4105KUZ arsenate reductase AOR13_2020 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AOR13_2023 ENOG4105K8R UPF0145 protein AOR13_2025 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AOR13_2026 ENOG4105BZU Histidine kinase AOR13_2027 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AOR13_2028 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AOR13_2029 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AOR13_2030 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOR13_2032 ENOG4105F8C transglutaminase domain-containing protein AOR13_2033 ENOG4105TMB Formate nitrite transporter AOR13_2034 ENOG4105D9P serine threonine protein kinase AOR13_2035 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AOR13_2040 ENOG4105ETT transcriptional Regulator, LysR family AOR13_2042 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AOR13_2043 ENOG4108YY7 Invasion gene expression up-regulator SirB AOR13_2044 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOR13_2045 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AOR13_2046 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AOR13_2047 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AOR13_2048 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AOR13_2049 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AOR13_2051 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AOR13_2052 ENOG4105BZU Histidine kinase AOR13_2054 ENOG4105DQ4 alcohol dehydrogenase AOR13_2055 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AOR13_2056 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AOR13_2057 ENOG4105C3G gtp-binding protein AOR13_2058 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AOR13_2063 ENOG4105BZG amino acid carrier protein AOR13_2064 ENOG4107XWI flavin reductase domain protein, FMN-binding AOR13_207 ENOG4105DZG Dehydrogenase AOR13_2070 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AOR13_2071 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOR13_2072 ENOG4105C9A Phoh family AOR13_2073 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AOR13_2074 ENOG4108JU5 Magnesium and cobalt efflux protein AOR13_2075 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AOR13_2076 ENOG4105C6K Malic enzyme AOR13_2077 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AOR13_2078 ENOG4108ZNX Heat shock protein AOR13_2082 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_2083 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AOR13_2084 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AOR13_2085 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AOR13_2086 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AOR13_2088 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOR13_209 ENOG4105BZU Histidine kinase AOR13_2091 ENOG41085AF Cytochrome AOR13_2092 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AOR13_2093 ENOG4105CFG Acts as a chaperone (By similarity) AOR13_2094 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AOR13_2098 ENOG4105CY2 Citrate transporter AOR13_2099 ENOG4105DWV Homoserine O-trans-acetylase AOR13_210 ENOG4105BZU Histidine kinase AOR13_2101 ENOG4105DTD Dehydrogenase AOR13_2102 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AOR13_2103 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AOR13_2104 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AOR13_2105 ENOG4105FQ6 thiopurine methyltransferase AOR13_2106 ENOG4106BRA Membrane AOR13_2110 ENOG4108UW5 maltose o-acetyltransferase AOR13_2111 ENOG4105CV8 reductase AOR13_2113 ENOG4105FE9 pseudouridine synthase AOR13_2114 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AOR13_2115 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AOR13_2116 ENOG4107RTD sua5 ycio yrdc ywlc family protein AOR13_2117 ENOG4105DB7 PHP domain protein AOR13_2118 ENOG4105CRQ synthase (Component I) AOR13_2120 ENOG4108I0Q anthranilate phosphoribosyltransferase AOR13_2121 ENOG4105DK0 Indole-3-glycerol phosphate synthase AOR13_2122 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AOR13_2123 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AOR13_2124 ENOG4105K9H YciI-like protein AOR13_2127 ENOG4105XJC Two component transcriptional regulator (Winged helix family AOR13_2128 ENOG4105IFJ Histidine kinase AOR13_2129 ENOG4105DSF transport protein AOR13_2130 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase AOR13_2131 ENOG4105ECP epimerase AOR13_2132 ENOG4105CV6 ABC transporter, permease AOR13_2133 ENOG4108I0Y (ABC) transporter AOR13_2134 ENOG4108UJV acyl-CoA thioesterase i AOR13_2137 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AOR13_2145 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AOR13_2149 ENOG4105XJC Two component transcriptional regulator (Winged helix family AOR13_2151 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOR13_2152 ENOG4108JJ7 ABC transporter AOR13_2155 ENOG410600T transposase AOR13_2156 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase AOR13_2157 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AOR13_2158 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) AOR13_2159 ENOG4105KJF protein tyrosine phosphatase AOR13_216 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOR13_2161 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AOR13_2162 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOR13_2163 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOR13_2164 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AOR13_2165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOR13_2168 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOR13_2169 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AOR13_217 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AOR13_2172 ENOG4105C5S asparaginyl-tRNA synthetase AOR13_2174 ENOG4105F1S paraquat-inducible protein a AOR13_2175 ENOG4105DY2 Paraquat-inducible protein b AOR13_2177 ENOG4105BZU Histidine kinase AOR13_2181 ENOG4105CN8 Transcriptional regulator AOR13_2182 ENOG4108XG4 DNA-binding transcriptional regulator AOR13_2184 ENOG4105BZS acriflavin resistance protein AOR13_2185 ENOG4105W87 Cbs domain AOR13_2189 ENOG4105HEI LysR family (Transcriptional regulator AOR13_219 ENOG4105BZU Histidine kinase AOR13_2190 ENOG4105DS1 cytochrome b561 AOR13_2197 ENOG4105CXY transporter AOR13_2206 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOR13_2208 ENOG4105BZU Histidine kinase AOR13_2213 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AOR13_2217 ENOG4105UFD tol-pal system protein YbgF AOR13_2218 ENOG4105KCK Peptidoglycan-associated lipoprotein AOR13_2219 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AOR13_2221 ENOG4105M8F Biopolymer transport protein exbD tolR AOR13_2222 ENOG4105E02 MotA TolQ exbB proton channel AOR13_2223 ENOG4107YD3 Thioesterase AOR13_2224 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AOR13_2225 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AOR13_2226 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AOR13_2227 ENOG4108TIT dATP pyrophosphohydrolase AOR13_2228 ENOG4105C9M aspartyl-trna synthetase AOR13_2231 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_2233 ENOG4107WP9 Histidine kinase AOR13_2235 ENOG4105BZU Histidine kinase AOR13_2237 ENOG4105BZU Histidine kinase AOR13_2239 ENOG4108ZJT translation initiation factor, Sui1 AOR13_2240 ENOG4108VYJ response regulator receiver protein AOR13_2242 ENOG4108N3W hemolysin secretion protein AOR13_2244 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AOR13_2245 ENOG4105EN6 Membrane AOR13_2249 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AOR13_2250 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AOR13_2251 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AOR13_2252 ENOG4105K5M 30s ribosomal protein S16 AOR13_2256 ENOG4105BZ1 (ABC) transporter AOR13_2257 ENOG4105ENT Efflux transporter rnd family, mfp subunit AOR13_2259 ENOG4105DN9 Na H antiporter AOR13_2265 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AOR13_2266 ENOG4106KVJ cytochrome C assembly protein AOR13_2267 ENOG4108JU6 CBS domain protein AOR13_2269 ENOG4108BY2 phosphohistidine phosphatase AOR13_2270 ENOG4107QXK peptidase AOR13_2271 ENOG4105BZU Histidine kinase AOR13_2274 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOR13_2275 ENOG4105CHU acetyl-coa acetyltransferase AOR13_2276 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOR13_2280 ENOG4107QVM von Willebrand factor, type A AOR13_2285 ENOG4105BZU Histidine kinase AOR13_2286 ENOG4105CK7 Sodium proline symporter AOR13_2287 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AOR13_2288 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AOR13_2289 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AOR13_2290 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AOR13_2296 ENOG4105CAQ asparagine synthetase AOR13_2298 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AOR13_2299 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AOR13_23 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AOR13_230 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AOR13_2303 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOR13_2304 ENOG4107QJQ Mate efflux family protein AOR13_2307 ENOG4105DGN Electron transport complex AOR13_2308 ENOG4108R3D Electron transport complex AOR13_231 ENOG4105BZU Histidine kinase AOR13_2310 ENOG4105D6A Electron transport complex AOR13_2311 ENOG4108UQQ Electron transport complex AOR13_2312 ENOG4105DZB Electron transport complex AOR13_2313 ENOG4105CSM endonuclease III AOR13_2315 ENOG4105CSM endonuclease III AOR13_2316 ENOG4105DWV Homoserine O-trans-acetylase AOR13_2317 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AOR13_2320 ENOG4105BZU Histidine kinase AOR13_2322 ENOG4105VEQ Cold shock protein AOR13_2323 ENOG4108UYE Lactoylglutathione lyase AOR13_2324 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AOR13_2325 ENOG4105EIY sodium-type flagellar protein motY AOR13_2326 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AOR13_2327 ENOG4105D3R alkyl hydroperoxide reductase AOR13_2332 ENOG4105D05 Receptor AOR13_2333 ENOG4105M2J Glutaredoxin AOR13_2334 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOR13_2335 ENOG4105CYN Serine protein kinase AOR13_2336 ENOG4106AKX UPF0229 protein AOR13_2339 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AOR13_2340 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AOR13_2343 ENOG4105BZU Histidine kinase AOR13_2344 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_2347 ENOG4105C19 ABC transporter AOR13_235 ENOG4105CDV Ompa motb domain protein AOR13_2351 ENOG4105D9M gamma-glutamylcysteine synthetase AOR13_2354 ENOG4108W1A pseudouridine synthase AOR13_2355 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AOR13_2356 ENOG4105CRK lysyL-tRNA synthetase AOR13_2357 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AOR13_2361 ENOG4108QDA dioxygenase AOR13_2364 ENOG4105BZU Histidine kinase AOR13_2365 ENOG4105C75 arginyL-tRNA synthetase AOR13_2366 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AOR13_2369 ENOG4105HEI LysR family (Transcriptional regulator AOR13_2372 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AOR13_2380 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AOR13_2382 ENOG410822N TonB family AOR13_2383 ENOG4109015 Biopolymer transport protein exbD tolR AOR13_2393 ENOG4107RDJ Sulfotransferase AOR13_2394 ENOG4108KPZ tonB-dependent Receptor AOR13_2395 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AOR13_2397 ENOG4107RDP Dehydrogenase AOR13_2398 ENOG4108XM1 transcriptional regulator AsnC family AOR13_2399 ENOG4108RXX maleylacetoacetate isomerase AOR13_2403 ENOG4105MIR Phenylalanine 4-monooxygenase AOR13_2405 ENOG4105YYT phage shock protein B AOR13_2406 ENOG41087YS Phage shock protein A AOR13_2407 ENOG4105E51 psp operon transcriptional activator AOR13_2408 ENOG4105DEF Extracellular solute-binding protein, family 5 AOR13_2409 ENOG4108I5W peptide transport system, permease protein AOR13_2410 ENOG4108EU3 peptide transport system, permease AOR13_2411 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AOR13_2412 ENOG4108JQ2 peptide transport system atp-binding protein AOR13_2413 ENOG4105D9Q decarboxylase (Beta subunit) AOR13_2414 ENOG4107QSA Oxaloacetate decarboxylase AOR13_2416 ENOG4108S4H thioesterase Superfamily protein AOR13_2420 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AOR13_2421 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOR13_2425 ENOG4105C9K Endothelin-converting enzyme 1 AOR13_2426 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AOR13_2427 ENOG4105CHH sulfate transporter AOR13_2428 ENOG4107B2H carbonic anhydrase AOR13_2429 ENOG4105C5Q Transcriptional regulator AOR13_2430 ENOG4105DZ2 Transcriptional regulator AOR13_2432 ENOG4105C3R Methionine synthase AOR13_2433 ENOG4105C3R Methionine synthase AOR13_2434 ENOG4105CVG Homoserine O-transsuccinylase AOR13_2436 ENOG4105YFD chemotaxis, protein AOR13_2438 ENOG4107QJE Chromosome Partitioning Protein AOR13_2439 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AOR13_2440 ENOG4105CBS Chea signal transduction histidine kinase AOR13_2441 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AOR13_2442 ENOG4108VYJ response regulator receiver protein AOR13_2443 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOR13_2445 ENOG4105FZW flagellar biosynthesis regulator FlhF AOR13_2446 ENOG4105D7B Flagellar biosynthesis protein flha AOR13_2447 ENOG4105D00 flagellar biosynthetic protein flhB AOR13_2448 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AOR13_2449 ENOG4105VS8 Flagellar biosynthetic protein fliq AOR13_2450 ENOG4105CN7 Flagellar biosynthetic protein FliP AOR13_2451 ENOG4105VTB flagellar biosynthesis protein fliO AOR13_2452 ENOG4105DD5 Flagellar motor switch protein AOR13_2453 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AOR13_2457 ENOG4108JIR Flagellum-specific ATP synthase AOR13_2459 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AOR13_246 ENOG4108WBH protein TIM barrel AOR13_2460 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AOR13_2462 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_2463 ENOG4105BZU Histidine kinase AOR13_2464 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_2466 ENOG4105C5E polysaccharide biosynthesis protein AOR13_2467 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AOR13_2468 ENOG4105F0R Cytidylyltransferase AOR13_2474 ENOG4105CHR reductase AOR13_248 ENOG4105CEY Amp-dependent synthetase and ligase AOR13_2481 ENOG4105D2T synthase AOR13_2482 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AOR13_2483 ENOG4105C0K Gdp-mannose 4,6-dehydratase AOR13_2488 ENOG4105MQ3 flagellar protein FliS AOR13_249 ENOG4105DUU IucA IucC family protein AOR13_2490 ENOG41063QE flagellar protein FlaG AOR13_2491 ENOG4105I03 Flagellin AOR13_2492 ENOG4105I03 Flagellin AOR13_2493 ENOG4105I03 Flagellin AOR13_2496 ENOG4105E1Q flagellar hook-associated protein AOR13_2497 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AOR13_2498 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AOR13_2499 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AOR13_25 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AOR13_2500 ENOG4105CGA flagellar basal-body rod protein FlgG AOR13_2501 ENOG4108KPB Flagellar basal-body rod protein FlgF AOR13_2502 ENOG4105BZE flagellar hook protein, FlgE AOR13_2503 ENOG4105W00 Flagellar hook capping protein AOR13_2504 ENOG4108ZC9 flagellar basal-body rod protein flgc AOR13_2505 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AOR13_2506 ENOG4105BZU Histidine kinase AOR13_2507 ENOG4107R88 Chemotaxis protein (CheV) AOR13_2515 ENOG4105WH1 Two component transcriptional regulator luxr family AOR13_2517 ENOG4108JJA ABC, transporter AOR13_2518 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 AOR13_2522 ENOG4108DG9 Smr protein MutS2 AOR13_2524 ENOG4108ETH Formylglycinamide ribotide synthetase AOR13_2525 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AOR13_2527 ENOG4108Z6B deaminase AOR13_2530 ENOG4105BZU Histidine kinase AOR13_2531 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AOR13_2532 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AOR13_2533 ENOG4105C0B DNA polymerase III (alpha subunit) AOR13_2534 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AOR13_2535 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOR13_2536 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOR13_2537 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AOR13_2540 ENOG4105DZP Membrane-associated zinc metalloprotease AOR13_2541 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOR13_2542 ENOG4105KNE Phosphatidate cytidylyltransferase AOR13_2543 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AOR13_2544 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AOR13_2545 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AOR13_2546 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AOR13_2547 ENOG4105CE9 30S ribosomal protein S2 AOR13_2549 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOR13_2550 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AOR13_2551 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AOR13_2552 ENOG4105QDK Flavodoxin AOR13_2553 ENOG4105DR9 pseudouridine synthase AOR13_2560 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOR13_2565 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AOR13_2566 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AOR13_2567 ENOG4105BZU Histidine kinase AOR13_2568 ENOG4105EWT decarboxylase family AOR13_257 ENOG4105K6V RNA polymerase AOR13_2571 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOR13_2572 ENOG4105KQC Competence protein AOR13_2573 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AOR13_2575 ENOG4108RYC glycosyltransferase AOR13_2576 ENOG4105ESV Glycosyl transferase, family 4 AOR13_2578 ENOG4107V1M polysaccharide export protein AOR13_2579 ENOG41090SZ ABC-2 type transporter AOR13_2582 ENOG4105DUX Transporter AOR13_2583 ENOG4105CMR udp-glucose 4-epimerase AOR13_2584 ENOG410903C (LipO)protein AOR13_2586 ENOG4108M1T Cytochrome c-type biogenesis protein AOR13_2587 ENOG4107QX9 Thiol disulfide interChange protein AOR13_2588 ENOG4105DA4 cytochrome c-type biogenesis protein AOR13_2589 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AOR13_259 ENOG4108K5H permease YjgP YjgQ family protein AOR13_2590 ENOG4105X3C heme exporter protein AOR13_2591 ENOG41060IM Heme exporter protein AOR13_2592 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AOR13_2593 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AOR13_2597 ENOG4108SDH ABC, transporter AOR13_2598 ENOG4108IUW ABC transporter AOR13_2599 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AOR13_260 ENOG4108M8S permease YjgP YjgQ family protein AOR13_2601 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AOR13_2602 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AOR13_2603 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AOR13_2607 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AOR13_2608 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOR13_2609 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AOR13_261 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AOR13_2610 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AOR13_2611 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOR13_2614 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AOR13_2616 ENOG4105C1J atp-dependent rna helicase AOR13_2617 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AOR13_2618 ENOG4105CSA Coproporphyrinogen iii oxidase AOR13_262 ENOG4105MYG DNA polymerase iii, chi subunit AOR13_2625 ENOG41067MG lrgb family AOR13_263 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AOR13_2639 ENOG4108KPZ tonB-dependent Receptor AOR13_264 ENOG4105BZU Histidine kinase AOR13_2644 ENOG4108NRW Phospholipase, patatin family AOR13_2647 ENOG4107RNH Outer membrane receptor FepA AOR13_2651 ENOG4105C5H ABC transporter AOR13_2653 ENOG4105CE4 GlcNAc 6-P deacetylase AOR13_2654 ENOG4105RD7 BadF BadG BcrA BcrD AOR13_2656 ENOG4105BZU Histidine kinase AOR13_2657 ENOG4105EYH Exonuclease AOR13_2658 ENOG4107RH8 nuclease SbcCD subunit D AOR13_2659 ENOG4107SDU Methyl-accepting chemotaxis AOR13_2660 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AOR13_2663 ENOG4108ZHJ Organic hydroperoxide resistance protein AOR13_2664 ENOG4105K56 Transcriptional regulator AOR13_2668 ENOG4105QV4 Tryptophan halogenase AOR13_2669 ENOG4106R3P AraC family transcriptional regulator AOR13_267 ENOG4105BZU Histidine kinase AOR13_2670 ENOG4105E08 Glycoside hydrolase, family 9 AOR13_2672 ENOG4105C93 Xylose Isomerase AOR13_2673 ENOG4105CMG Carbohydrate kinase AOR13_2674 ENOG4105T16 Transcriptional regulator (AraC family) AOR13_2678 ENOG4105BZU Histidine kinase AOR13_2679 ENOG4108UT2 hemolysin iii AOR13_2684 ENOG4105C5Q Transcriptional regulator AOR13_2686 ENOG4105CJ3 phosphate transporter AOR13_2688 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AOR13_2689 ENOG4105C8U phosphate abc transporter AOR13_269 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) AOR13_2692 ENOG4105C9X ppx gppa phosphatase AOR13_2693 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AOR13_2694 ENOG4105WYW fructose-bisphosphate aldolase AOR13_2695 ENOG4105BZA Phosphoglycerate kinase AOR13_2696 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AOR13_2697 ENOG4105CV1 Transketolase (EC 2.2.1.1) AOR13_2699 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AOR13_270 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AOR13_2703 ENOG4108I6A alcohol dehydrogenase AOR13_2705 ENOG4105CF7 AraC family transcriptional regulator AOR13_2706 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AOR13_2707 ENOG4105BZU Histidine kinase AOR13_2708 ENOG4105BZU Histidine kinase AOR13_271 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOR13_2711 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOR13_2716 ENOG4105CDY transcriptional regulatory protein AOR13_2717 ENOG4105D6Z AFG1 family ATPase AOR13_2719 ENOG4105C0H protease AOR13_272 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_2721 ENOG4105C0H protease AOR13_2722 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AOR13_2723 ENOG4105VFK BolA family AOR13_2725 ENOG4105E3I toluene tolerance AOR13_2726 ENOG4107PE3 Mammalian cell entry related domain protein AOR13_2727 ENOG4105CY3 ABC transporter, permease AOR13_2728 ENOG4105DHJ ABC, transporter AOR13_273 ENOG4105CUX Signal transduction histidine kinase AOR13_2730 ENOG4105C2X Arabinose 5-phosphate isomerase AOR13_2731 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AOR13_2734 ENOG4108IUZ ABC transporter AOR13_2735 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AOR13_2736 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AOR13_2737 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AOR13_2738 ENOG41080Z8 PHOSPHOCARRIER protein AOR13_2739 ENOG4105CJW magnesium transporter AOR13_2742 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOR13_2743 ENOG4105KB2 stringent starvation protein b AOR13_2744 ENOG4107MKT Stringent starvation protein a AOR13_2745 ENOG4105EIX cytochrome c1 AOR13_2746 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOR13_2747 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOR13_2748 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B AOR13_275 ENOG4105C5F glutamine synthetase AOR13_2750 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AOR13_2752 ENOG4108SF5 RNA Polymerase AOR13_2753 ENOG4108UJD 30S ribosomal protein S9 AOR13_2754 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AOR13_2757 ENOG4105DXN mazG family AOR13_2758 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOR13_2759 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOR13_2760 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AOR13_2761 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AOR13_2762 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AOR13_2764 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AOR13_2765 ENOG4105T95 Thiol disulfide interChange protein AOR13_2766 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOR13_2767 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AOR13_2768 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AOR13_2769 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AOR13_2770 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AOR13_2772 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AOR13_2773 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_2775 ENOG4105CFH Aspartokinase AOR13_2777 ENOG4107QIJ Aconitate hydratase 2 AOR13_2780 ENOG4107QIJ Aconitate hydratase 2 AOR13_2783 ENOG4105CEY Amp-dependent synthetase and ligase AOR13_2784 ENOG4105BZU Histidine kinase AOR13_2785 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOR13_2786 ENOG41061N2 exported protein AOR13_2788 ENOG41067XB TonB family AOR13_2789 ENOG4109015 Biopolymer transport protein exbD tolR AOR13_279 ENOG4105C87 Aminotransferase class I and II AOR13_2797 ENOG4105BZU Histidine kinase AOR13_2798 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOR13_2799 ENOG4105BZU Histidine kinase AOR13_280 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AOR13_2800 ENOG4105DH7 May be involved in recombination (By similarity) AOR13_2802 ENOG4108JCI Transcriptional regulator AOR13_2803 ENOG4105DKK Benzoate AOR13_2806 ENOG4105K59 histidine triad (HIT) protein AOR13_2807 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOR13_2809 ENOG4105KRF dihydroneopterin aldolase AOR13_2810 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AOR13_2812 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOR13_2813 ENOG4105VCC 30S ribosomal protein S21 AOR13_2814 ENOG4105KTH gatB Yqey AOR13_2815 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AOR13_2816 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOR13_2817 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_2821 ENOG4105BZS acriflavin resistance protein AOR13_2822 ENOG410624X efflux transporter, rnd family, mfp subunit AOR13_2824 ENOG4105MP9 class II Aldolase AOR13_2825 ENOG4105CXK mandelate racemase muconate lactonizing AOR13_2829 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AOR13_283 ENOG4108YXA Membrane AOR13_2830 ENOG4105CSU acyl-Coa dehydrogenase AOR13_2834 ENOG4105C58 cytochrome c oxidase accessory protein ccog AOR13_2835 ENOG4105E27 serine threonine protein kinase AOR13_2837 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AOR13_2838 ENOG4108Z33 Thiol disulfide Interchange Protein AOR13_2841 ENOG4105D7T ABC transporter AOR13_2842 ENOG4105DG7 nitrate ABC transporter AOR13_2844 ENOG4107SDU Methyl-accepting chemotaxis AOR13_2846 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOR13_2848 ENOG4105WZK nitrite reductase NADPH small subunit AOR13_2849 ENOG4107QZF nitrite reductase NADPH large subunit AOR13_2851 ENOG4105CHH sulfate transporter AOR13_2855 ENOG4105YVM Phosphoesterase, PA-phosphatase related AOR13_2856 ENOG4105M85 Bola protein AOR13_2858 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AOR13_2859 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AOR13_2862 ENOG4105UGU tonB-dependent Receptor AOR13_2863 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AOR13_2864 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AOR13_2865 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AOR13_2869 ENOG4107VXZ Hydrolase AOR13_287 ENOG4105C9Q fumarate hydratase class II AOR13_2870 ENOG4105BZU Histidine kinase AOR13_2871 ENOG4105BZU Histidine kinase AOR13_2873 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOR13_2875 ENOG4105IPS esterase AOR13_2878 ENOG41087AY ADP-Ribose pyrophosphatase AOR13_2879 ENOG4105DFG type I secretion outer membrane protein AOR13_2882 ENOG4105C1J atp-dependent rna helicase AOR13_2883 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOR13_2885 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AOR13_2886 ENOG4105CBG Sulfatase AOR13_2887 ENOG4105QRC ig domain protein group 2 domain protein AOR13_289 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AOR13_2893 ENOG41061MV Arylsulfatase AOR13_29 ENOG4107QN1 sodium solute AOR13_290 ENOG4107QMS site-determining protein AOR13_2900 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AOR13_291 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AOR13_2915 ENOG4106A3M Cytochrome p-450 AOR13_2918 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AOR13_292 ENOG4105CSR polyphosphate kinase 2 AOR13_2921 ENOG4105DIA mandelate racemase muconate lactonizing AOR13_2922 ENOG4105CPQ Dehydrogenase AOR13_2923 ENOG4105CHR reductase AOR13_2924 ENOG4105C26 Dehydrogenase AOR13_2925 ENOG4105CBG Sulfatase AOR13_2927 ENOG4108WYP Transcriptional regulator AOR13_293 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AOR13_2930 ENOG4108IAB Phoh family AOR13_2932 ENOG4105D3G Pseudouridine synthase AOR13_2936 ENOG4105BZU Histidine kinase AOR13_2937 ENOG4105BZU Histidine kinase AOR13_2938 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AOR13_2939 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AOR13_294 ENOG4108U78 Glutathione S-transferase AOR13_2940 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AOR13_2941 ENOG4105HF0 Membrane AOR13_2942 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AOR13_2944 ENOG4105I7R Adenylate cyclase AOR13_2945 ENOG4106MWK domain protein AOR13_2946 ENOG4105F3H Histidine kinase AOR13_2947 ENOG4105XJC Two component transcriptional regulator (Winged helix family AOR13_2948 ENOG4105BZS acriflavin resistance protein AOR13_295 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AOR13_2951 ENOG4105C26 Dehydrogenase AOR13_2952 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_2954 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AOR13_2955 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AOR13_2957 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AOR13_2958 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AOR13_2959 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AOR13_2960 ENOG4108UM1 dedA family AOR13_2967 ENOG4108VEQ Superoxide dismutase AOR13_2969 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AOR13_297 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOR13_2970 ENOG4105K46 50S ribosomal protein l27 AOR13_2971 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AOR13_2972 ENOG4105EAH synthase AOR13_2974 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) AOR13_2976 ENOG4107SC1 transglycosylase AOR13_2977 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOR13_2978 ENOG4105CHU acetyl-coa acetyltransferase AOR13_298 ENOG4105TW1 Carbohydrate-selective porin OprB AOR13_299 ENOG4105EDR glucose galactose transporter AOR13_3 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AOR13_30 ENOG4105C2X Arabinose 5-phosphate isomerase AOR13_3004 ENOG4105K3M )-transporter AOR13_3008 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AOR13_301 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AOR13_3012 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOR13_3013 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AOR13_3014 ENOG4105EHZ conserved protein UCP016719 AOR13_3018 ENOG4107S6Z Na H antiporter AOR13_3019 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AOR13_302 ENOG4105DR5 peptidase AOR13_3022 ENOG4105C26 Dehydrogenase AOR13_3023 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AOR13_3026 ENOG4107QR8 Thioredoxin AOR13_303 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOR13_3032 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AOR13_3033 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AOR13_3034 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AOR13_3036 ENOG4105CH2 amidohydrolase AOR13_3038 ENOG4105K63 Thioredoxin AOR13_3039 ENOG4105C1J atp-dependent rna helicase AOR13_3040 ENOG4105C9X ppx gppa phosphatase AOR13_3041 ENOG4105D52 delta-aminolevulinic acid dehydratase AOR13_3042 ENOG4105BZU Histidine kinase AOR13_3045 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AOR13_3046 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AOR13_3047 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AOR13_3049 ENOG4108ZP8 Acetolactate synthase small subunit AOR13_3050 ENOG4105C7K acetolactate synthase AOR13_3053 ENOG4107RDJ Sulfotransferase AOR13_3054 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AOR13_3057 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AOR13_3059 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AOR13_306 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AOR13_3060 ENOG4105DJ4 phosphatidylserine decarboxylase AOR13_3062 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOR13_3064 ENOG4105PXI polysaccharide deacetylase AOR13_3066 ENOG41063SB peptidase AOR13_3069 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AOR13_307 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AOR13_3071 ENOG4105E0F Histidine kinase AOR13_3072 ENOG4105E3W Two component transcriptional regulator (Winged helix family AOR13_3075 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AOR13_3077 ENOG4108Z5K methylglyoxal synthase AOR13_3078 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AOR13_3079 ENOG4105CAS nag kinase AOR13_3080 ENOG4105DBV ornithine carbamoyltransferase AOR13_3081 ENOG4105CDH Citrulline--aspartate ligase AOR13_3082 ENOG4105CH7 arginosuccinase AOR13_3083 ENOG4107QZM n-acetylglutamate synthase AOR13_3084 ENOG4105BZU Histidine kinase AOR13_309 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AOR13_3091 ENOG4105CYM Glutathione S-transferase AOR13_3093 ENOG4107R1I NAD-dependent malic enzyme AOR13_3094 ENOG4108JQC penicillin-binding protein 1A AOR13_3099 ENOG4105E4G Type IV pilus AOR13_3100 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AOR13_3101 ENOG4105D49 3-dehydroquinate synthase AOR13_3104 ENOG4105DFE Dna adenine methylase AOR13_3109 ENOG4105DJV ribulose-phosphate 3-epimerase AOR13_3110 ENOG4105C31 Tryptophanyl-tRNA synthetase AOR13_3111 ENOG4105DDQ anthranilate synthase AOR13_3113 ENOG4105C8Y Acetylornithine aminotransferase AOR13_3115 ENOG4105C26 Dehydrogenase AOR13_3117 ENOG4105BZU Histidine kinase AOR13_3119 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOR13_312 ENOG4108J20 pectate lyase AOR13_3120 ENOG4105BZU Histidine kinase AOR13_3125 ENOG4105CXT aspartate transcarbamylase AOR13_3126 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AOR13_3128 ENOG4105EZR dyp-type peroxidase family protein AOR13_3129 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AOR13_3132 ENOG4108YZA Nitrogen regulatory protein pii AOR13_3136 ENOG4105CKW Inner membrane protein yedI AOR13_3138 ENOG4105BZ4 penicillin-binding protein AOR13_3140 ENOG4105CVE Lytic murein transglycosylase AOR13_3141 ENOG4105CQ7 ATP-dependent helicase AOR13_3145 ENOG4105DGW oligopeptidase A AOR13_3146 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_3150 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AOR13_3151 ENOG4105D16 lipopolysaccharide heptosyltransferase i AOR13_3152 ENOG4105CPK Glycosyl transferase (Group 1 AOR13_3153 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AOR13_3154 ENOG41083MP 50s ribosomal protein l29 AOR13_3155 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AOR13_3156 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AOR13_3157 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AOR13_3158 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AOR13_3159 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AOR13_3160 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AOR13_3161 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AOR13_3162 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AOR13_3163 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AOR13_3164 ENOG4107QHF type ii secretion system protein e AOR13_3166 ENOG4107QM5 aconitate hydratase AOR13_3167 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AOR13_3168 ENOG4105C0A alcohol dehydrogenase AOR13_3176 ENOG4105EAA nucleoside AOR13_3179 ENOG4105ETE Transcriptional regulator (LacI family AOR13_318 ENOG4105VZ8 Transcriptional regulator AOR13_3186 ENOG4105E53 ec 3.2.1.28 AOR13_3190 ENOG4105D0M Protease HtpX homolog AOR13_3193 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AOR13_3194 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AOR13_3195 ENOG4105BZU Histidine kinase AOR13_3196 ENOG4107SDU Methyl-accepting chemotaxis AOR13_3197 ENOG4108V3W Chemotaxis protein, CheW AOR13_3198 ENOG4105CBS Chea signal transduction histidine kinase AOR13_3199 ENOG4108VYJ response regulator receiver protein AOR13_32 ENOG4105BZU Histidine kinase AOR13_320 ENOG4105BZ8 glutamate synthase AOR13_3200 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_3203 ENOG410804D Sensor Signal Transduction Histidine Kinase AOR13_321 ENOG4105CBC glutamate synthase AOR13_3210 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AOR13_3211 ENOG4105CEN a g-specific adenine glycosylase AOR13_3213 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AOR13_3214 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AOR13_3215 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AOR13_3216 ENOG4105BZU Histidine kinase AOR13_3217 ENOG41065U4 response regulator AOR13_3218 ENOG4105CNT hydrolase family 2 AOR13_322 ENOG4105BZU Histidine kinase AOR13_3220 ENOG4105CMS peptidase U62, modulator of DNA gyrase AOR13_3221 ENOG4105N42 UPF0307 protein AOR13_3223 ENOG4105D1U peptidase U62 modulator of DNA gyrase AOR13_3226 ENOG4105C03 ribonuclease AOR13_3227 ENOG4108Z03 MAF-like protein AOR13_3228 ENOG4105VQ7 Rod shape-determining protein MreD AOR13_3229 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AOR13_3230 ENOG4105DFF Rod shape-determining protein mreb AOR13_3238 ENOG4105D7Q type ii secretion system AOR13_3239 ENOG4107QHF type ii secretion system protein e AOR13_3248 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AOR13_3249 ENOG4105E98 transcriptional regulator DeoR family AOR13_3250 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AOR13_3254 ENOG4107RUZ Sss sodium solute transporter superfamily AOR13_3260 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOR13_3261 ENOG4105D58 Diguanylate phosphodiesterase AOR13_3262 ENOG4105BZU Histidine kinase AOR13_3263 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOR13_3266 ENOG4105IBP Cyclic peptide transporter AOR13_3270 ENOG4105CEY Amp-dependent synthetase and ligase AOR13_3271 ENOG4108TU9 TRANSCRIPTIONal AOR13_3279 ENOG4107XMK single-stranded DNA-binding protein AOR13_3282 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AOR13_3283 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AOR13_3285 ENOG41060NJ transcriptional regulator AOR13_3287 ENOG4107VXZ Hydrolase AOR13_3288 ENOG4107RDB Major Facilitator AOR13_3289 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOR13_3290 ENOG4105DFF Rod shape-determining protein mreb AOR13_3294 ENOG4105F0N pyrophosphate phospho-hydrolase AOR13_3295 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AOR13_3297 ENOG4105DFU Cell wall formation (By similarity) AOR13_3298 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AOR13_3300 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AOR13_3304 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOR13_3305 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AOR13_3308 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AOR13_3309 ENOG4105D7W serine acetyltransferase AOR13_331 ENOG4105BZU Histidine kinase AOR13_3310 ENOG4105C4R Atp-dependent dna helicase AOR13_3311 ENOG4105BZU Histidine kinase AOR13_3312 ENOG4105FR1 rard protein AOR13_3313 ENOG4105CJW magnesium transporter AOR13_3314 ENOG4108VUY thioesterase Superfamily protein AOR13_3315 ENOG4105C9U ATP-dependent DNA helicase RecQ AOR13_3317 ENOG4105CNG UPF0061 protein AOR13_3319 ENOG4105BZU Histidine kinase AOR13_332 ENOG4105C7F AcnD-accessory protein PrpF AOR13_3320 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AOR13_3321 ENOG4108NST exported protein AOR13_3323 ENOG4108N3W hemolysin secretion protein AOR13_3326 ENOG4105CYC Transferase AOR13_3328 ENOG4105BZS acriflavin resistance protein AOR13_3329 ENOG4105C1P efflux transporter, rnd family, mfp subunit AOR13_333 ENOG4108I0Z Aconitate hydratase AOR13_3332 ENOG4105KPY Small multidrug resistance protein AOR13_3334 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AOR13_3336 ENOG4105BZU Histidine kinase AOR13_334 ENOG4105BZN citrate synthase AOR13_3342 ENOG4105CBX hi0933 family AOR13_3343 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOR13_3344 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component AOR13_3347 ENOG4105EHV domain protein AOR13_3348 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AOR13_3349 ENOG4105CB5 ATP-dependent DNA helicase recG AOR13_3350 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AOR13_3351 ENOG4105KME endoribonuclease L-psp AOR13_3352 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOR13_3353 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AOR13_3354 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AOR13_3356 ENOG4105BZU Histidine kinase AOR13_3357 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AOR13_3359 ENOG4105ECF c-methyltransferase AOR13_336 ENOG4105CR4 methylisocitrate lyase AOR13_3360 ENOG410601J HemY protein AOR13_3361 ENOG4105CD3 dihydroorotase AOR13_3362 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AOR13_3363 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AOR13_3364 ENOG4105C26 Dehydrogenase AOR13_3366 ENOG4105EVZ LysR family transcriptional regulator AOR13_3367 ENOG4108R86 Transcriptional regulator AOR13_3368 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AOR13_3369 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AOR13_3370 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase AOR13_3371 ENOG4105YV1 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) AOR13_3372 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) AOR13_3374 ENOG4105DYW oxidoreductase AOR13_3376 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AOR13_3378 ENOG4105D06 uba thif-type nad fad binding protein AOR13_3380 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AOR13_3381 ENOG4105D41 biosynthesis protein thiH AOR13_3385 ENOG4105CM6 amino acid regulated cytosolic protein AOR13_3388 ENOG4105DQS Transcriptional regulator AOR13_3389 ENOG4105C1G acyl-Coa dehydrogenase AOR13_3391 ENOG4105CMI transporter AOR13_3392 ENOG4105CJ1 ABC, transporter AOR13_3393 ENOG4105D0S secretion protein (HlyD AOR13_3395 ENOG4105C26 Dehydrogenase AOR13_3396 ENOG4108M0I Transcriptional regulator AOR13_3397 ENOG4105CNM Receptor AOR13_3398 ENOG4105BZU Histidine kinase AOR13_3399 ENOG4107RDJ Sulfotransferase AOR13_3401 ENOG4105C26 Dehydrogenase AOR13_3402 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AOR13_3403 ENOG4105CXK mandelate racemase muconate lactonizing AOR13_3404 ENOG4105C26 Dehydrogenase AOR13_3408 ENOG4105ETT transcriptional Regulator, LysR family AOR13_3409 ENOG4105EJQ L-serine dehydratase AOR13_341 ENOG4108ZGX Histidine kinase AOR13_3410 ENOG4105C94 Transporter AOR13_3417 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AOR13_3418 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOR13_3420 ENOG4105DVW rieske (2Fe-2S) AOR13_3421 ENOG4105ECQ AraC Family Transcriptional Regulator AOR13_3426 ENOG4105DF6 Fe-S oxidoreductase AOR13_3429 ENOG4105DAA L-lactate AOR13_3430 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOR13_3431 ENOG4105NI8 Cytosine-specific methyltransferase AOR13_3432 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AOR13_3436 ENOG4105DFD Na H antiporter AOR13_3437 ENOG4105VZ1 Replication Protein AOR13_3438 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOR13_3440 ENOG4105MPD Cytochrome AOR13_3441 ENOG4105BZU Histidine kinase AOR13_3442 ENOG4105C4R Atp-dependent dna helicase AOR13_3443 ENOG4105W0Z cytoplasmic protein AOR13_3444 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AOR13_3445 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AOR13_3447 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AOR13_3448 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AOR13_3449 ENOG4105CPQ Dehydrogenase AOR13_3450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOR13_3451 ENOG4105BZU Histidine kinase AOR13_3455 ENOG4105DKP glycosyl transferase, family 9 AOR13_3456 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) AOR13_3457 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AOR13_3458 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AOR13_3460 ENOG4105W0E 50S ribosomal protein L33 AOR13_3461 ENOG4105KDC 50s ribosomal protein l28 AOR13_3464 ENOG4105E3R (LipO)protein AOR13_3468 ENOG4105W5Q DNA repair protein (RadC AOR13_3469 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AOR13_3470 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AOR13_3472 ENOG4105IIU Aminopeptidase AOR13_3476 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AOR13_3478 ENOG4105C0B DNA polymerase III (alpha subunit) AOR13_3493 ENOG4108Z0R Transferase AOR13_3494 ENOG4105E2X shikimate dehydrogenase AOR13_3496 ENOG4105EIF outer membrane protein W AOR13_3497 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AOR13_3498 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOR13_35 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) AOR13_350 ENOG4105W4M Transport-associated protein AOR13_3500 ENOG4108RPN Protein smg homolog AOR13_3501 ENOG4105C79 DNA protecting protein DprA AOR13_3503 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOR13_3505 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AOR13_3506 ENOG4105C1A potassium transporter peripheral membrane AOR13_3507 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AOR13_3508 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AOR13_3509 ENOG4105C2M dna polymerase I AOR13_351 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AOR13_3510 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AOR13_3511 ENOG4106RE7 Cytochrome AOR13_3512 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AOR13_3515 ENOG4108R3E Dna-3-methyladenine glycosylase i AOR13_3516 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit AOR13_3517 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AOR13_352 ENOG41082RQ UPF0102 protein AOR13_3520 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOR13_3521 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AOR13_3522 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOR13_3524 ENOG4105VG0 50S ribosomal protein l34 AOR13_3525 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AOR13_3526 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AOR13_3527 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AOR13_3528 ENOG4108VPT UPF0234 protein AOR13_3529 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AOR13_353 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) AOR13_3530 ENOG4105QTB Flavodoxin AOR13_3533 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AOR13_3534 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AOR13_3535 ENOG4107QJE Chromosome Partitioning Protein AOR13_3536 ENOG4105FA0 parb-like partition protein AOR13_3538 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AOR13_3539 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AOR13_354 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AOR13_3540 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AOR13_3541 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AOR13_3542 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AOR13_3543 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AOR13_3544 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AOR13_3548 ENOG4108K3A Glutathione S-transferase AOR13_3550 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOR13_3551 ENOG4105CDV Ompa motb domain protein AOR13_3553 ENOG41060NJ transcriptional regulator AOR13_3554 ENOG4105CT4 transporter AOR13_3557 ENOG4105QV4 Tryptophan halogenase AOR13_3560 ENOG4105DSJ YicC domain protein AOR13_3561 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AOR13_3562 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AOR13_3563 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AOR13_3564 ENOG4108TM9 integral membrane protein AOR13_357 ENOG4105E3Q saccharopine dehydrogenase AOR13_3578 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AOR13_3580 ENOG4105C5I Dehydrogenase AOR13_3585 ENOG4105MA0 exported protein AOR13_3586 ENOG4105CFU surface antigen AOR13_3589 ENOG4105C2C drug resistance transporter, Bcr CflA AOR13_3590 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOR13_3591 ENOG4105EMY transcriptional regulator AOR13_3592 ENOG4105C0P Mg chelatase subunit ChlI AOR13_3593 ENOG4105EN6 Membrane AOR13_3594 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOR13_3595 ENOG4105C01 Dihydroxy-acid dehydratase AOR13_3596 ENOG4105C7B Threonine dehydratase AOR13_3597 ENOG4105E55 glycerol-3-phosphate acyltransferase AOR13_3600 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AOR13_3601 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AOR13_3602 ENOG4105BZ9 Cytochrome C oxidase, subunit I AOR13_3603 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) AOR13_3608 ENOG4107SF2 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AOR13_3609 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AOR13_3613 ENOG4107R73 Mate efflux family protein AOR13_3614 ENOG4105F4I Transcriptional regulator AOR13_3619 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AOR13_362 ENOG4105BZU Histidine kinase AOR13_3621 ENOG4105MJ2 Competence protein AOR13_3622 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AOR13_3625 ENOG4105BZM domain protein AOR13_3626 ENOG4108RRZ Transcription elongation factor GreB AOR13_3628 ENOG4108V1T peptidylprolyl cis-trans isomerase AOR13_363 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOR13_3633 ENOG4105C5H ABC transporter AOR13_3635 ENOG4105DNZ Alpha Beta Hydrolase AOR13_3636 ENOG4105YP7 UPF0270 protein AOR13_3639 ENOG4105DJ9 glucan biosynthesis protein AOR13_364 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AOR13_3643 ENOG4107RK2 ADP-ribose diphosphatase NudE AOR13_3644 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AOR13_3647 ENOG4105C26 Dehydrogenase AOR13_3648 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AOR13_365 ENOG4107YTP response regulator receiver protein AOR13_3656 ENOG4108VAU general secretion pathway protein G AOR13_3657 ENOG4105D7Q type ii secretion system AOR13_3658 ENOG4107QHF type ii secretion system protein e AOR13_366 ENOG4105CAU Arsenical resistance protein, ArsH AOR13_3660 ENOG4108XKW General secretion pathway protein C AOR13_3661 ENOG4105VEJ Heat shock protein AOR13_3662 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AOR13_3663 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AOR13_3666 ENOG4105E0F Histidine kinase AOR13_3667 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOR13_3669 ENOG4105CNM Receptor AOR13_3670 ENOG4105C2W permease AOR13_3671 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AOR13_3674 ENOG4105EYW Ion transport protein AOR13_3676 ENOG4105C12 Phosphoribosylglycinamide synthetase AOR13_3678 ENOG4105DC1 bifunctional purine biosynthesis protein purh AOR13_3679 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AOR13_368 ENOG41082YX Transcriptional regulator, arsr family AOR13_3680 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOR13_3681 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AOR13_3684 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOR13_3689 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOR13_3693 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOR13_3694 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AOR13_3695 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AOR13_3696 ENOG4105DR5 peptidase AOR13_3697 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AOR13_3699 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AOR13_3700 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AOR13_3701 ENOG4105BZU Histidine kinase AOR13_3704 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AOR13_3707 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AOR13_3708 ENOG4105W8H transhydrogenase (subunit alpha AOR13_3709 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AOR13_3712 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AOR13_3713 ENOG41066YJ Beta-lactamase AOR13_3714 ENOG4105ECQ AraC Family Transcriptional Regulator AOR13_3715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOR13_3716 ENOG4108Q5Y Membrane AOR13_3718 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AOR13_372 ENOG4105BZU Histidine kinase AOR13_3720 ENOG4105E98 transcriptional regulator DeoR family AOR13_3721 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AOR13_3725 ENOG4107ENK receptor AOR13_3728 ENOG4105CKI cobalamin synthesis protein AOR13_373 ENOG4105WH1 Two component transcriptional regulator luxr family AOR13_3732 ENOG4108I0Y (ABC) transporter AOR13_3734 ENOG4105DEN Luciferase family AOR13_3739 ENOG4105BZU Histidine kinase AOR13_3741 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AOR13_3743 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AOR13_3744 ENOG4105JQN Transcriptional regulator AOR13_375 ENOG4105CC0 LysR family Transcriptional regulator AOR13_3750 ENOG4105CEP NADH dehydrogenase AOR13_3751 ENOG4108YYC ycei family AOR13_3752 ENOG4105DS1 cytochrome b561 AOR13_3757 ENOG4108MUZ hydrolase AOR13_3758 ENOG4108YZN class I peptide chain release factor AOR13_3766 ENOG4105VDW Csbd family AOR13_377 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AOR13_3775 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein AOR13_3781 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AOR13_3788 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_379 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AOR13_3790 ENOG4105C4M (Ubiquinol oxidase) subunit I AOR13_3791 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOR13_3793 ENOG4108JJ9 ABC, transporter AOR13_3794 ENOG4108JJ8 (ABC) transporter AOR13_3795 ENOG4107ZSV Receptor AOR13_38 ENOG4105D9N nucleoside AOR13_3803 ENOG4105PGM cation diffusion facilitator family transporter AOR13_3804 ENOG4107RUZ Sss sodium solute transporter superfamily AOR13_3807 ENOG4105FDP GntR family transcriptional regulator AOR13_3809 ENOG4106IBS oxygenase AOR13_381 ENOG4107QP8 phosphohexose isomerase AOR13_3810 ENOG4105HMI Membrane AOR13_3815 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AOR13_3817 ENOG4107R4I Periplasmic binding protein AOR13_3818 ENOG4105EHG Permease protein AOR13_3819 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AOR13_382 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOR13_3822 ENOG4105CT4 transporter AOR13_3823 ENOG41060NJ transcriptional regulator AOR13_3824 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_3825 ENOG4105BZU Histidine kinase AOR13_3828 ENOG4105BZU Histidine kinase AOR13_3829 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AOR13_383 ENOG4105D1Q UPF0246 protein AOR13_3830 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AOR13_3831 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AOR13_3834 ENOG4108RPX mosc domain containing protein AOR13_3839 ENOG4105CDU Replicative dna helicase AOR13_384 ENOG4108K3A Glutathione S-transferase AOR13_3840 ENOG4105CDV Ompa motb domain protein AOR13_3841 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AOR13_3843 ENOG4105MYN Zinc uptake regulation protein AOR13_3844 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor AOR13_3845 ENOG4105E09 nadh pyrophosphatase AOR13_3846 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AOR13_3848 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AOR13_3849 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AOR13_385 ENOG4108Z7R Chaperone CsaA AOR13_3850 ENOG4105K8N protein family UPF0079, ATPase AOR13_3851 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AOR13_3852 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AOR13_3853 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AOR13_3854 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AOR13_3855 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AOR13_3856 ENOG4107QJR hflk protein AOR13_3857 ENOG4105EPW hflc protein AOR13_3858 ENOG4105CFC Transporter AOR13_3859 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AOR13_3861 ENOG4105C7K acetolactate synthase AOR13_3864 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AOR13_3865 ENOG4107IFA Lipase (EC 3.1.1.3) AOR13_3868 ENOG4105CYM Glutathione S-transferase AOR13_3871 ENOG4105D7K pfkb domain protein AOR13_3873 ENOG4107T0X DNA ligase AOR13_3876 ENOG4107QRT dEAD DEAH box helicase AOR13_3877 ENOG41068D6 Glycosyltransferase AOR13_388 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOR13_3881 ENOG4105DWY Agmatine deiminase AOR13_3882 ENOG4106B0W Curli production assembly transport component CsgG AOR13_3884 ENOG4107Y60 (LipO)protein AOR13_3886 ENOG4105EUJ GTP cyclohydrolase i AOR13_3888 ENOG4107QW3 Sucrose phosphorylase AOR13_3890 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AOR13_3891 ENOG4107QM2 Aldo Keto reductase AOR13_3892 ENOG4105QNF Outer membrane lipoprotein AOR13_3894 ENOG4105EKE dihydroorotase AOR13_3895 ENOG4105C1J atp-dependent rna helicase AOR13_3897 ENOG4105C9K Endothelin-converting enzyme 1 AOR13_3899 ENOG4105JSC dimethylmenaquinone methyltransferase AOR13_39 ENOG4105DBI uridine monophosphokinase AOR13_3900 ENOG4105BZ1 (ABC) transporter AOR13_3902 ENOG4105PM1 preprotein translocase subunit SecE AOR13_3903 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AOR13_3904 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AOR13_3905 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AOR13_3906 ENOG4108VZM 50s ribosomal protein L10 AOR13_3907 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AOR13_3908 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOR13_3909 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOR13_391 ENOG4108VIA integral membrane protein AOR13_3910 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AOR13_3911 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AOR13_3912 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AOR13_3913 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AOR13_392 ENOG4105II7 pyrroline-5-carboxylate reductase AOR13_3923 ENOG4105D22 carbon starvation protein AOR13_3924 ENOG4108PJD permease AOR13_3928 ENOG4107E2E PKHD-type hydroxylase AOR13_3929 ENOG4108ESX Receptor AOR13_393 ENOG4105DFA alanine racemase domain protein AOR13_3930 ENOG4105EB3 Histidine kinase AOR13_3931 ENOG4105E3W Two component transcriptional regulator (Winged helix family AOR13_3933 ENOG4105DA5 (ABC) transporter AOR13_3934 ENOG4105E3A (ABC) transporter AOR13_3936 ENOG4105BZU Histidine kinase AOR13_3938 ENOG4105DY8 decarboxylase AOR13_3939 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AOR13_394 ENOG4105CZX twitching motility protein AOR13_3940 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AOR13_3941 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AOR13_3942 ENOG4105DJ0 Poly(A) Polymerase AOR13_3943 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AOR13_3944 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AOR13_3945 ENOG4105PW4 Sugar fermentation stimulation protein homolog AOR13_3946 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AOR13_3948 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AOR13_395 ENOG4105CZX twitching motility protein AOR13_3950 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AOR13_3951 ENOG4105CAK Cell division ATP-binding protein ftsE AOR13_3952 ENOG4105CRP Part of the ABC transporter FtsEX involved in AOR13_3953 ENOG4105D58 Diguanylate phosphodiesterase AOR13_3954 ENOG4105D58 Diguanylate phosphodiesterase AOR13_3956 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOR13_3957 ENOG4105SUU thioesterase domain AOR13_3958 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AOR13_3962 ENOG4107S2Z UPF0761 membrane protein AOR13_3963 ENOG4105SYT Methylenetetrahydrofolate reductase AOR13_3964 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AOR13_3965 ENOG4105C6K Malic enzyme AOR13_3967 ENOG4105VFB Binds the 23S rRNA (By similarity) AOR13_3968 ENOG4105C25 Primosomal protein n' AOR13_3969 ENOG41063M6 Cell Division Protein AOR13_397 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AOR13_3970 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AOR13_3971 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AOR13_3975 ENOG4108JJA ABC, transporter AOR13_398 ENOG4108UJU UPF0301 protein AOR13_3980 ENOG4107RE3 peptidase, S41 AOR13_3981 ENOG4107QY8 reductase AOR13_3982 ENOG4105DC8 reductase AOR13_3983 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_3986 ENOG4107Z9R response regulator AOR13_3988 ENOG4105DGW oligopeptidase A AOR13_399 ENOG4105D7Z glutathione synthase AOR13_3992 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AOR13_3993 ENOG4105VEQ Cold shock protein AOR13_3996 ENOG4108XM1 transcriptional regulator AsnC family AOR13_3997 ENOG4105C8Q Methyl-accepting chemotaxis AOR13_3998 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOR13_3999 ENOG4105C4M (Ubiquinol oxidase) subunit I AOR13_4 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AOR13_400 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOR13_4003 ENOG4107VAM peptidase, m28 AOR13_4004 ENOG4107QK7 reductase AOR13_4005 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AOR13_4008 ENOG4108UV7 flagellar protein motX AOR13_4011 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AOR13_4012 ENOG4105C2N RNA methyltransferase TrmH family group 3 AOR13_4013 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AOR13_4015 ENOG4105BZU Histidine kinase AOR13_4016 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AOR13_4017 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AOR13_4018 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AOR13_4019 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AOR13_402 ENOG4105D64 Mechanosensitive ion channel AOR13_4020 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AOR13_4021 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AOR13_4022 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AOR13_4023 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AOR13_4024 ENOG4105VPB 50S ribosomal protein L30 AOR13_4025 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AOR13_4026 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOR13_4028 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AOR13_4029 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AOR13_4030 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AOR13_4031 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOR13_4032 ENOG4108ZT0 50S ribosomal protein l17 AOR13_4033 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AOR13_4038 ENOG41061MV Arylsulfatase AOR13_4041 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AOR13_4042 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AOR13_4051 ENOG4107RGC Glycosyl transferase, family 2 AOR13_4053 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AOR13_4054 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AOR13_4055 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AOR13_4056 ENOG4105C1B dTDP-glucose 4-6-dehydratase AOR13_406 ENOG4105BZU Histidine kinase AOR13_407 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOR13_411 ENOG4105EHV domain protein AOR13_417 ENOG4108IGT Dipeptidase AOR13_419 ENOG4108V6E Cell division protein mraZ AOR13_42 ENOG4108KPZ tonB-dependent Receptor AOR13_420 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AOR13_421 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AOR13_422 ENOG4105CJN penicillin-binding protein AOR13_423 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOR13_424 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AOR13_425 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AOR13_426 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AOR13_427 ENOG4105CNI cell division protein FtsW AOR13_428 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOR13_429 ENOG4105DFU Cell wall formation (By similarity) AOR13_430 ENOG4105CPF Cell wall formation (By similarity) AOR13_431 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AOR13_432 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOR13_433 ENOG4105DR5 peptidase AOR13_434 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOR13_435 ENOG4105M6F mutator MutT protein AOR13_436 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) AOR13_437 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AOR13_438 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AOR13_441 ENOG4105D7Q type ii secretion system AOR13_442 ENOG4108ZUW Major pilin subunit AOR13_443 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AOR13_448 ENOG41073TP transcriptional regulator AOR13_449 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AOR13_45 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AOR13_450 ENOG4107QSN dihydrolipoamide acetyltransferase AOR13_451 ENOG4107QN2 dihydrolipoyl dehydrogenase AOR13_458 ENOG4105XZD Fe-S protein AOR13_46 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOR13_462 ENOG4108JQ1 Dehydrogenase AOR13_463 ENOG4105E66 phosphoriboisomerase A AOR13_464 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AOR13_466 ENOG4105DU0 nucleoside hydrolase AOR13_467 ENOG4108RVA ribokinase AOR13_469 ENOG4107RAQ aminopeptidase AOR13_470 ENOG4105D0A hydroxylase AOR13_471 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AOR13_474 ENOG4105DC7 peptidase M24 AOR13_476 ENOG4105C27 TonB-dependent Receptor Plug AOR13_480 ENOG4108HKT sucrose-6-phosphate hydrolase AOR13_481 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AOR13_482 ENOG4106NDP Transcriptional regulator AOR13_485 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AOR13_486 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AOR13_487 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AOR13_49 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AOR13_494 ENOG4108J1Q AOR13_50 ENOG4108V1T peptidylprolyl cis-trans isomerase AOR13_501 ENOG4105CV8 reductase AOR13_503 ENOG4105F27 Major Facilitator AOR13_51 ENOG4105RKW reductase (By AOR13_514 ENOG4105C1J atp-dependent rna helicase AOR13_515 ENOG4105XDF Protein of unknown function (DUF1272) AOR13_516 ENOG4108594 Permease of the drug metabolite transporter AOR13_522 ENOG4105DFD Na H antiporter AOR13_528 ENOG4108VKG metal-dependent hydrolase AOR13_532 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOR13_535 ENOG4108HMN Caspase domain AOR13_539 ENOG4108JUA Transcriptional regulator AOR13_54 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AOR13_542 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOR13_543 ENOG4105DVC DnaJ domain protein AOR13_545 ENOG4105ETT transcriptional Regulator, LysR family AOR13_549 ENOG4108VWS Yaeq family AOR13_55 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AOR13_550 ENOG4105C9U ATP-dependent DNA helicase RecQ AOR13_551 ENOG4107U9T Pfam:Ribonuclease_BN AOR13_553 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AOR13_554 ENOG4105Y49 secretion protein, HlyD family AOR13_558 ENOG4107RNH Outer membrane receptor FepA AOR13_56 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AOR13_561 ENOG4108JU7 Transcriptional regulator AOR13_562 ENOG4107ZSV Receptor AOR13_566 ENOG4107U7N hydantoinase B oxoprolinase AOR13_567 ENOG4108UAU isochorismatase AOR13_568 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AOR13_569 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AOR13_57 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AOR13_573 ENOG4108J1Q AOR13_576 ENOG4105PGM cation diffusion facilitator family transporter AOR13_577 ENOG4105PGM cation diffusion facilitator family transporter AOR13_58 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AOR13_587 ENOG4108Z0Z intracellular protease Pfpi family AOR13_588 ENOG4105EMU Dehydrogenase AOR13_589 ENOG4105JQN Transcriptional regulator AOR13_59 ENOG4105CJ2 (LipO)protein AOR13_593 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AOR13_594 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AOR13_595 ENOG4105CCU oxidase (Subunit III) AOR13_596 ENOG4105BZ9 Cytochrome C oxidase, subunit I AOR13_597 ENOG4105E2S oxidase) subunit II AOR13_599 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AOR13_606 ENOG4105KSC Transcriptional regulator, TraR DksA family AOR13_608 ENOG4105NA0 Transcriptional regulator AOR13_609 ENOG4105KVH Transcriptional regulator AOR13_611 ENOG4105CHR reductase AOR13_614 ENOG4105ETT transcriptional Regulator, LysR family AOR13_62 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOR13_620 ENOG4105C57 major facilitator superfamily AOR13_628 ENOG4105CFP Peptidase U32 AOR13_629 ENOG4105NAU thioesterase Superfamily protein AOR13_631 ENOG4107T0K Adenylate cyclase AOR13_633 ENOG4108RCM Nitroreductase AOR13_634 ENOG4105BZU Histidine kinase AOR13_635 ENOG4107XDR Lactoylglutathione lyase AOR13_641 ENOG4105D6Z AFG1 family ATPase AOR13_643 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOR13_646 ENOG4105CNM Receptor AOR13_647 ENOG4108IGT Dipeptidase AOR13_649 ENOG4105CSU acyl-Coa dehydrogenase AOR13_65 ENOG4108YXU transcriptional regulator AsnC family AOR13_657 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AOR13_660 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AOR13_663 ENOG4108Z4X TRANSCRIPTIONal AOR13_665 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AOR13_668 ENOG4108Z12 YiaAB two helix domain-containing protein AOR13_669 ENOG4107RBR Receptor AOR13_673 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AOR13_676 ENOG4105E0K tonB-dependent siderophore receptor AOR13_680 ENOG4105CXN decarboxylase AOR13_682 ENOG4108DT4 serine threonine protein kinase AOR13_687 ENOG4105DZ0 fad dependent oxidoreductase AOR13_688 ENOG4108Z4U Ferredoxin AOR13_689 ENOG4108RWN rrna methyltransferase AOR13_69 ENOG4105E7A Glutamine amidotransferase AOR13_690 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AOR13_697 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AOR13_70 ENOG4108WAV Transcriptional regulator AOR13_701 ENOG4107104 thymidine kinase AOR13_702 ENOG4105BZU Histidine kinase AOR13_704 ENOG4107QPN acyl-Coa dehydrogenase AOR13_710 ENOG4105D1S lipid A biosynthesis AOR13_712 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AOR13_714 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AOR13_717 ENOG4108QV3 biosynthesis protein AOR13_72 ENOG4105C5X domain protein AOR13_720 ENOG4105D3Q Sugar transferase AOR13_724 ENOG4105K64 Glycosyl transferase, family 2 AOR13_73 ENOG4105EFZ amidohydrolase AOR13_733 ENOG4105CPK Glycosyl transferase (Group 1 AOR13_734 ENOG4107T8Q Glycosyl transferase (Group 1 AOR13_737 ENOG4107QZ7 Cellulose synthase catalytic subunit AOR13_738 ENOG4105D7W serine acetyltransferase AOR13_739 ENOG4105CUZ uba thif-type nad fad binding protein AOR13_749 ENOG4107RET Isocitrate lyase AOR13_75 ENOG4105BZU Histidine kinase AOR13_751 ENOG4105G6Z alkaline phosphatase AOR13_752 ENOG4105CSV Glutaminase AOR13_755 ENOG4106032 Glutathionylspermidine synthase AOR13_76 ENOG4105KWG Pfam:DUF1696 AOR13_760 ENOG4108P9J Phage shock protein A AOR13_761 ENOG4105FUX Conserved Protein AOR13_763 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AOR13_764 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AOR13_765 ENOG4105VIE preprotein translocase, subunit YajC AOR13_766 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOR13_767 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOR13_769 ENOG4105BZU Histidine kinase AOR13_773 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AOR13_776 ENOG4105C3J Cysteine desulfurase AOR13_778 ENOG4105C3K feS assembly ATPase SufC AOR13_779 ENOG4105JRK feS assembly protein SufD AOR13_78 ENOG4105K4T epimerase AOR13_780 ENOG4105C9B Cysteine desulfurase AOR13_781 ENOG4108Z4V iron-sulfur cluster assembly AOR13_783 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AOR13_784 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AOR13_785 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AOR13_788 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AOR13_789 ENOG4105CUT histidyl-tRNA synthetase AOR13_79 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AOR13_790 ENOG4105N21 Membrane AOR13_791 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AOR13_792 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AOR13_794 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOR13_795 ENOG4105EXC Acyl-transferase AOR13_796 ENOG4108NVR Methyl-accepting chemotaxis AOR13_797 ENOG4105DGU Histone deacetylase AOR13_798 ENOG4105HDD phospholipase AOR13_800 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AOR13_801 ENOG4108R96 Methyltransferase, YaeB family AOR13_803 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AOR13_809 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AOR13_810 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOR13_811 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AOR13_814 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AOR13_815 ENOG4105K70 DNA-binding protein AOR13_817 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOR13_819 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AOR13_82 ENOG4107QZ7 Cellulose synthase catalytic subunit AOR13_823 ENOG4105C09 Bile acid AOR13_824 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AOR13_827 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AOR13_828 ENOG4105CJR Integral membrane protein (MviN AOR13_829 ENOG4105DTN riboflavin biosynthesis protein ribF AOR13_830 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOR13_831 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AOR13_832 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AOR13_833 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AOR13_845 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AOR13_846 ENOG4108YZA Nitrogen regulatory protein pii AOR13_847 ENOG4108YZY peptidylprolyl cis-trans isomerase AOR13_848 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AOR13_849 ENOG4105Y75 tpr repeat protein AOR13_85 ENOG4105EJG cellulose synthase AOR13_852 ENOG4108IYU L-aspartate oxidase AOR13_853 ENOG4105EMN RNA polymerase sigma factor AOR13_858 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AOR13_859 ENOG4105C3F Signal peptidase i AOR13_862 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AOR13_863 ENOG4105EYA deoxyribonuclease AOR13_865 ENOG4105EAC phosphoserine phosphatase AOR13_867 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AOR13_869 ENOG4105C5H ABC transporter AOR13_87 ENOG4109015 Biopolymer transport protein exbD tolR AOR13_870 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOR13_871 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AOR13_872 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AOR13_873 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AOR13_876 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AOR13_877 ENOG4107YIM Involved in the transcription termination process (By similarity) AOR13_878 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AOR13_879 ENOG4108ZAI phosphatidylglycerophosphatase a AOR13_880 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AOR13_881 ENOG4105CTB Polyprenyl synthetase AOR13_882 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AOR13_883 ENOG4105E14 MotA TolQ exbB proton channel AOR13_884 ENOG4106VK6 Flagellar motor protein AOR13_885 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AOR13_889 ENOG4105EMU Dehydrogenase AOR13_892 ENOG4105K6V RNA polymerase AOR13_894 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AOR13_895 ENOG4105C34 Pseudouridine synthase AOR13_896 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AOR13_897 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOR13_9 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AOR13_90 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AOR13_901 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOR13_911 ENOG4108HMN Caspase domain AOR13_913 ENOG4105E18 UPF0276 protein AOR13_915 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AOR13_916 ENOG4107QMP dna polymerase iii subunits gamma and tau AOR13_917 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AOR13_922 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AOR13_923 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AOR13_924 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AOR13_927 ENOG4105C3F Signal peptidase i AOR13_929 ENOG4105C5X domain protein AOR13_93 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AOR13_932 ENOG4105DHQ Histidine kinase AOR13_936 ENOG4105CKK Glycosyl transferase, family 2 AOR13_938 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AOR13_940 ENOG4108IQE Amp-dependent synthetase and ligase AOR13_942 ENOG4107JEE Short-chain dehydrogenase reductase Sdr AOR13_944 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AOR13_945 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AOR13_946 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AOR13_947 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AOR13_948 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AOR13_949 ENOG4105CIH Imidazole acetol-phosphate transaminase AOR13_950 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AOR13_951 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AOR13_965 ENOG4105DVT helicase AOR13_966 ENOG41072GX Peptidase M22 Glycoprotease AOR13_97 ENOG4105C8J )-transporter AOR13_970 ENOG410832A alpha/beta hydrolase fold AOR13_971 ENOG4105CEY Amp-dependent synthetase and ligase AOR13_972 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AOR13_973 ENOG4105VNG YcgL domain-containing protein AOR13_975 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AOR13_976 ENOG4108ZZ3 UPF0260 protein AOR13_977 ENOG4108428 Inherit from COG: -acetyltransferase AOR13_978 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AOR13_979 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AOR13_98 ENOG4108535 NAD dependent epimerase/dehydratase family AOR13_980 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AOR13_987 ENOG4108UH6 UPF0754 membrane protein AOR13_988 ENOG4105U5Y Transcriptional regulator AOR13_989 ENOG4105D8T Acyltransferase AOR13_994 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOR13_998 ENOG4105W1Y Transcriptional regulator