locus-tag	class	description
A6K25_00015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6K25_00020	COG1138	Cytochrome C-type biogenesis protein
A6K25_00030	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6K25_00035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6K25_00040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6K25_00045	COG4133	protoheme IX ABC transporter activity
A6K25_00065	COG1668	transmembrane transport
A6K25_00070	COG4555	ABC transporter
A6K25_00085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6K25_00115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6K25_00120	COG0473	3-isopropylmalate dehydrogenase activity
A6K25_00130	COG0066	3-isopropylmalate dehydratase activity
A6K25_00135	COG3437	response regulator, receiver
A6K25_00135	COG0784	Response regulator, receiver
A6K25_00145	COG3267	Type II secretory pathway component ExeA
A6K25_00145	COG3409	Peptidoglycan-binding domain 1 protein
A6K25_00155	COG0513	Belongs to the DEAD box helicase family
A6K25_00165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6K25_00195	COG1346	cytolysis
A6K25_00265	COG4667	esterase of the alpha-beta hydrolase superfamily
A6K25_00300	COG0488	(ABC) transporter
A6K25_00310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6K25_00315	COG2971	BadF BadG BcrA BcrD
A6K25_00325	COG3706	GGDEF domain
A6K25_00330	COG0419	ATPase involved in DNA repair
A6K25_00335	COG0420	3'-5' exonuclease activity
A6K25_00345	COG1739	Uncharacterized protein family UPF0029
A6K25_00360	COG1764	response to oxidative stress
A6K25_00365	COG1846	Transcriptional regulator
A6K25_00370	COG1472	Belongs to the glycosyl hydrolase 3 family
A6K25_00385	COG2207	Transcriptional regulator
A6K25_00390	COG3291	Pkd domain containing protein
A6K25_00390	COG4447	cellulose binding
A6K25_00390	COG5520	Belongs to the glycosyl hydrolase 30 family
A6K25_00395	COG2115	Belongs to the xylose isomerase family
A6K25_00400	COG1070	Carbohydrate kinase
A6K25_00405	COG2207	Transcriptional regulator
A6K25_00405	COG1609	Transcriptional regulator
A6K25_00410	COG0477	Major facilitator Superfamily
A6K25_00430	COG1272	protein, Hemolysin III
A6K25_00455	COG0583	DNA-binding transcription factor activity
A6K25_00465	COG0306	phosphate transporter
A6K25_00475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6K25_00480	COG0581	inorganic phosphate transmembrane transporter activity
A6K25_00485	COG0573	inorganic phosphate transmembrane transporter activity
A6K25_00495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6K25_00500	COG0248	Ppx GppA phosphatase
A6K25_00505	COG0823	Involved in the tonB-independent uptake of proteins
A6K25_00505	COG1506	peptidase
A6K25_00505	COG4946	Tricorn protease homolog
A6K25_00510	COG3588	fructose-bisphosphate aldolase
A6K25_00515	COG0126	phosphoglycerate kinase activity
A6K25_00525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6K25_00550	COG1979	alcohol dehydrogenase
A6K25_00555	COG2207	Transcriptional regulator
A6K25_00565	COG2205	protein histidine kinase activity
A6K25_00565	COG0784	Response regulator, receiver
A6K25_00570	COG5001	Diguanylate cyclase
A6K25_00570	COG3300	MHYT domain
A6K25_00585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K25_00600	COG2207	Transcriptional regulator
A6K25_00615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6K25_00625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6K25_00630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6K25_00640	COG5007	Belongs to the BolA IbaG family
A6K25_00650	COG2854	intermembrane phospholipid transfer
A6K25_00655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6K25_00660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6K25_00665	COG1127	ABC transporter
A6K25_00680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6K25_00695	COG1137	ATPase activity
A6K25_00710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6K25_00720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6K25_00725	COG2239	Acts as a magnesium transporter
A6K25_00740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_00740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_00745	COG2969	positive regulation of protein catabolic process
A6K25_00750	COG0625	glutathione transferase activity
A6K25_00755	COG2857	Cytochrome c1
A6K25_00760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6K25_00765	COG0723	plastoquinol--plastocyanin reductase activity
A6K25_00770	COG1473	amidohydrolase
A6K25_00780	COG4206	TonB-dependent receptor
A6K25_00790	COG1595	DNA-templated transcription, initiation
A6K25_00795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6K25_00815	COG3956	TIGRFAM MazG family protein
A6K25_00820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6K25_00825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6K25_00835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6K25_00855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6K25_00865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6K25_00870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6K25_00875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K25_00880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6K25_00895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6K25_00900	COG0840	transmembrane signaling receptor activity
A6K25_00905	COG0527	aspartate kinase activity
A6K25_00925	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6K25_00930	COG2133	pyrroloquinoline quinone binding
A6K25_00940	COG0318	PFAM AMP-dependent synthetase and ligase
A6K25_00950	COG3437	response regulator, receiver
A6K25_00955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6K25_00965	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6K25_00970	COG0848	biopolymer transport protein
A6K25_00975	COG0811	peptide transport
A6K25_00980	COG0811	peptide transport
A6K25_01010	COG5002	protein histidine kinase activity
A6K25_01015	COG0745	RESPONSE REGULATOR receiver
A6K25_01020	COG4191	Histidine kinase
A6K25_01020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_01025	COG2974	May be involved in recombination
A6K25_01030	COG1396	sequence-specific DNA binding
A6K25_01035	COG3135	benzoate transporter
A6K25_01050	COG0537	adenosine 5'-monophosphoramidase activity
A6K25_01065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6K25_01070	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6K25_01090	COG1610	YqeY-like protein
A6K25_01095	COG0358	DNA primase activity
A6K25_01100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6K25_01120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_01125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_01140	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_01160	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_01165	COG1960	acyl-CoA dehydrogenase activity
A6K25_01180	COG0348	domain, Protein
A6K25_01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6K25_01190	COG4206	TonB-dependent receptor
A6K25_01195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6K25_01210	COG1116	anion transmembrane transporter activity
A6K25_01215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6K25_01220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6K25_01220	COG1116	anion transmembrane transporter activity
A6K25_01235	COG1648	precorrin-2 dehydrogenase activity
A6K25_01235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6K25_01240	COG0243	molybdopterin cofactor binding
A6K25_01245	COG2146	nitrite reductase [NAD(P)H] activity
A6K25_01250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6K25_01255	COG0659	secondary active sulfate transmembrane transporter activity
A6K25_01265	COG3707	response regulator
A6K25_01275	COG0671	phosphoesterase, PA-phosphatase related
A6K25_01280	COG0271	Belongs to the BolA IbaG family
A6K25_01295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6K25_01325	COG1509	lysine 2,3-aminomutase activity
A6K25_01345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_01350	COG4251	negative regulation of phosphorylation
A6K25_01365	COG3150	esterase
A6K25_01380	COG0494	nUDIX hydrolase
A6K25_01385	COG1538	Outer membrane efflux protein
A6K25_01405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6K25_01405	COG1648	precorrin-2 dehydrogenase activity
A6K25_01420	COG3119	arylsulfatase activity
A6K25_01455	COG3119	arylsulfatase activity
A6K25_01555	COG2124	cytochrome p450
A6K25_01575	COG2814	Major facilitator Superfamily
A6K25_01580	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_01585	COG1063	alcohol dehydrogenase
A6K25_01590	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_01595	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_01600	COG3119	arylsulfatase activity
A6K25_01605	COG1802	Transcriptional regulator
A6K25_01615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6K25_01625	COG0564	pseudouridine synthase activity
A6K25_01645	COG5002	protein histidine kinase activity
A6K25_01645	COG0784	Response regulator, receiver
A6K25_01650	COG3706	GGDEF domain
A6K25_01655	COG2201	protein-glutamate methylesterase activity
A6K25_01660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6K25_01665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6K25_01670	COG0730	response to heat
A6K25_01675	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A6K25_01680	COG0494	nUDIX hydrolase
A6K25_01695	COG3025	triphosphatase activity
A6K25_01700	COG4991	sh3 domain protein
A6K25_01705	COG2205	protein histidine kinase activity
A6K25_01705	COG2770	Histidine kinase
A6K25_01715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_01730	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6K25_01730	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6K25_01730	COG0506	proline dehydrogenase activity
A6K25_01735	COG0840	transmembrane signaling receptor activity
A6K25_01745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6K25_01760	COG0585	pseudouridine synthase activity
A6K25_01765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6K25_01775	COG1238	metal cluster binding
A6K25_01835	COG0142	geranyltranstransferase activity
A6K25_01845	COG0006	proline dipeptidase activity
A6K25_01855	COG1024	Enoyl-CoA hydratase
A6K25_01855	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6K25_01860	COG0183	Belongs to the thiolase family
A6K25_01930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6K25_01940	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_01960	COG0666	response to abiotic stimulus
A6K25_01970	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_01985	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
A6K25_02040	COG2161	toxin-antitoxin pair type II binding
A6K25_02045	COG4115	mRNA cleavage
A6K25_02105	COG0840	transmembrane signaling receptor activity
A6K25_02120	COG0346	lactoylglutathione lyase activity
A6K25_02140	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6K25_02145	COG3876	Protein conserved in bacteria
A6K25_02165	COG1757	Na H antiporter
A6K25_02185	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_02195	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6K25_02205	COG3118	belongs to the thioredoxin family
A6K25_02215	COG2133	pyrroloquinoline quinone binding
A6K25_02220	COG0783	Belongs to the Dps family
A6K25_02235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6K25_02245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6K25_02250	COG0784	Response regulator, receiver
A6K25_02250	COG2205	protein histidine kinase activity
A6K25_02260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6K25_02265	COG3118	belongs to the thioredoxin family
A6K25_02270	COG0513	Belongs to the DEAD box helicase family
A6K25_02275	COG0248	Ppx GppA phosphatase
A6K25_02285	COG3706	GGDEF domain
A6K25_02300	COG0805	protein transport
A6K25_02305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6K25_02325	COG0028	Belongs to the TPP enzyme family
A6K25_02340	COG0457	Tetratricopeptide repeat
A6K25_02360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6K25_02365	COG1162	GTPase activity
A6K25_02380	COG0584	glycerophosphoryl diester phosphodiesterase
A6K25_02390	COG2861	carbohydrate metabolic process
A6K25_02400	COG4942	peptidase
A6K25_02410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6K25_02425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6K25_02435	COG2205	protein histidine kinase activity
A6K25_02440	COG0745	RESPONSE REGULATOR receiver
A6K25_02455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6K25_02465	COG1803	Methylglyoxal synthase
A6K25_02480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6K25_02485	COG0137	argininosuccinate synthase activity
A6K25_02495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6K25_02495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6K25_02500	COG3300	MHYT domain
A6K25_02500	COG5001	Diguanylate cyclase
A6K25_02535	COG0625	glutathione transferase activity
A6K25_02540	COG0281	malic enzyme
A6K25_02545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6K25_02580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6K25_02590	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6K25_02610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6K25_02615	COG0180	Tryptophanyl-tRNA synthetase
A6K25_02620	COG0512	Glutamine amidotransferase of anthranilate synthase
A6K25_02630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6K25_02640	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_02665	COG3850	Histidine kinase
A6K25_02665	COG4999	Histidine kinase
A6K25_02665	COG3437	response regulator, receiver
A6K25_02665	COG2205	protein histidine kinase activity
A6K25_02690	COG0540	Belongs to the ATCase OTCase family
A6K25_02705	COG2837	iron assimilation
A6K25_02710	COG0405	Gamma-glutamyltransferase
A6K25_02715	COG0004	ammonium transporteR
A6K25_02740	COG2354	Protein conserved in bacteria
A6K25_02750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6K25_02760	COG2951	lytic endotransglycosylase activity
A6K25_02765	COG1643	Atp-dependent helicase
A6K25_02775	COG0788	formyltetrahydrofolate deformylase activity
A6K25_02785	COG0339	signal peptide processing
A6K25_02810	COG1519	Transferase
A6K25_02815	COG0859	PFAM glycosyl transferase family 9
A6K25_02820	COG0438	transferase activity, transferring glycosyl groups
A6K25_02825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6K25_02840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6K25_02850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6K25_02860	COG0089	rRNA binding
A6K25_02875	COG0051	transcription antitermination factor activity, RNA binding
A6K25_02900	COG1454	alcohol dehydrogenase
A6K25_02945	COG0673	inositol 2-dehydrogenase activity
A6K25_02950	COG1609	Transcriptional regulator
A6K25_03010	COG0501	Belongs to the peptidase M48B family
A6K25_03025	COG2201	protein-glutamate methylesterase activity
A6K25_03030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6K25_03045	COG0835	chemotaxis
A6K25_03050	COG2198	Histidine kinase
A6K25_03050	COG0643	Histidine kinase
A6K25_03055	COG0745	RESPONSE REGULATOR receiver
A6K25_03110	COG1194	a g-specific adenine glycosylase
A6K25_03120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6K25_03130	COG0297	glycogen (starch) synthase activity
A6K25_03135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_03135	COG4191	Histidine kinase
A6K25_03140	COG0745	RESPONSE REGULATOR receiver
A6K25_03155	COG0312	modulator of DNA gyrase
A6K25_03160	COG3028	Belongs to the UPF0307 family
A6K25_03170	COG0312	modulator of DNA gyrase
A6K25_03175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6K25_03185	COG1530	ribonuclease E activity
A6K25_03195	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6K25_03200	COG1792	Involved in formation and maintenance of cell shape
A6K25_03205	COG1077	Cell shape determining protein MreB Mrl
A6K25_03245	COG1459	type II secretion system
A6K25_03250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6K25_03260	COG3267	Type II secretory pathway component ExeA
A6K25_03260	COG3409	Peptidoglycan-binding domain 1 protein
A6K25_03300	COG1349	DNA-binding transcription factor activity
A6K25_03315	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_03355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6K25_03365	COG0745	RESPONSE REGULATOR receiver
A6K25_03380	COG4615	Cyclic peptide transporter
A6K25_03400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6K25_03410	COG3710	Transcriptional regulator
A6K25_03450	COG0629	single-stranded DNA binding
A6K25_03460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6K25_03465	COG1085	galactose-1-phosphate uridylyltransferase
A6K25_03485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_03490	COG2814	Major facilitator Superfamily
A6K25_03495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6K25_03520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6K25_03530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6K25_03535	COG0163	prenyltransferase activity
A6K25_03565	COG0019	diaminopimelate decarboxylase activity
A6K25_03570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6K25_03585	COG1011	Hydrolase
A6K25_03600	COG0745	RESPONSE REGULATOR receiver
A6K25_03600	COG3706	GGDEF domain
A6K25_03610	COG2239	Acts as a magnesium transporter
A6K25_03615	COG2050	protein possibly involved in aromatic compounds catabolism
A6K25_03620	COG0514	ATP-dependent DNA helicase (RecQ)
A6K25_03630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6K25_03640	COG5001	Diguanylate cyclase
A6K25_03640	COG5002	protein histidine kinase activity
A6K25_03645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6K25_03650	COG3064	Membrane
A6K25_03660	COG0840	transmembrane signaling receptor activity
A6K25_03670	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6K25_03675	COG0427	acetyl-CoA hydrolase
A6K25_03685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_03690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_03705	COG2076	Multidrug Resistance protein
A6K25_03715	COG0583	DNA-binding transcription factor activity
A6K25_03725	COG5002	protein histidine kinase activity
A6K25_03725	COG5001	Diguanylate cyclase
A6K25_03725	COG3447	MASE1 domain protein
A6K25_03750	COG0668	transmembrane transport
A6K25_03755	COG2081	HI0933 family
A6K25_03760	COG3842	ATPase activity
A6K25_03765	COG1178	ABC-type Fe3 transport system permease component
A6K25_03785	COG0678	peroxiredoxin activity
A6K25_03785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6K25_03795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6K25_03800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6K25_03810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6K25_03820	COG0194	GDP metabolic process
A6K25_03830	COG0745	RESPONSE REGULATOR receiver
A6K25_03830	COG3706	GGDEF domain
A6K25_03835	COG0181	hydroxymethylbilane synthase activity
A6K25_03845	COG2959	enzyme of heme biosynthesis
A6K25_03850	COG3071	HemY protein
A6K25_03855	COG2963	transposase activity
A6K25_03860	COG2801	Transposase and inactivated derivatives
A6K25_03870	COG1953	Uracil, thiamine, allantoin
A6K25_03895	COG1309	transcriptional regulator
A6K25_03900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6K25_03905	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6K25_03920	COG0778	Nitroreductase
A6K25_03920	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A6K25_03930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6K25_03935	COG4771	TonB-dependent receptor
A6K25_03965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6K25_03985	COG3106	COG3106 Predicted ATPase
A6K25_04000	COG0583	DNA-binding transcription factor activity
A6K25_04005	COG1960	acyl-CoA dehydrogenase activity
A6K25_04015	COG0842	Transport permease protein
A6K25_04020	COG1129	ABC transporter
A6K25_04020	COG0842	Transport permease protein
A6K25_04025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_04040	COG0583	DNA-binding transcription factor activity
A6K25_04045	COG4773	Receptor
A6K25_04050	COG2205	protein histidine kinase activity
A6K25_04050	COG3437	response regulator, receiver
A6K25_04050	COG3850	Histidine kinase
A6K25_04050	COG4999	Histidine kinase
A6K25_04055	COG0457	Tetratricopeptide repeat
A6K25_04060	COG4771	TonB-dependent receptor
A6K25_04065	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_04075	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_04080	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_04095	COG0583	DNA-binding transcription factor activity
A6K25_04100	COG1760	l-serine dehydratase
A6K25_04140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6K25_04145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6K25_04145	COG1017	nitric oxide dioxygenase activity
A6K25_04155	COG4638	Rieske (2fe-2S)
A6K25_04175	COG1902	pentaerythritol trinitrate reductase activity
A6K25_04175	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6K25_04195	COG1620	l-lactate permease
A6K25_04200	COG0556	nucleotide-excision repair
A6K25_04210	COG0326	Molecular chaperone. Has ATPase activity
A6K25_04225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6K25_04255	COG0210	DNA helicase
A6K25_04260	COG2960	long-chain fatty acid transporting porin activity
A6K25_04265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6K25_04270	COG3161	chorismate lyase activity
A6K25_04280	COG0705	Rhomboid family
A6K25_04285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6K25_04295	COG0156	8-amino-7-oxononanoate synthase activity
A6K25_04315	COG0859	PFAM glycosyl transferase family 9
A6K25_04320	COG3642	lipopolysaccharide core region biosynthetic process
A6K25_04360	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6K25_04385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6K25_04400	COG2234	aminopeptidase activity
A6K25_04420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6K25_04505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6K25_04520	COG3047	cAMP biosynthetic process
A6K25_04525	COG0408	coproporphyrinogen oxidase activity
A6K25_04530	COG0009	L-threonylcarbamoyladenylate synthase
A6K25_04545	COG0758	DNA mediated transformation
A6K25_04565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6K25_04565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6K25_04570	COG0569	domain protein
A6K25_04580	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6K25_04585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6K25_04585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6K25_04600	COG3078	GTPase activator activity
A6K25_04610	COG2818	Glycosylase
A6K25_04635	COG0187	DNA topoisomerase II activity
A6K25_04640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6K25_04655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6K25_04660	COG0594	ribonuclease P activity
A6K25_04665	COG0706	membrane insertase activity
A6K25_04675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6K25_04680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6K25_04705	COG1192	Involved in chromosome partitioning
A6K25_04710	COG1475	DNA binding
A6K25_04730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6K25_04735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6K25_04755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6K25_04785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6K25_04785	COG2199	diguanylate cyclase activity
A6K25_04800	COG1609	Transcriptional regulator
A6K25_04805	COG2211	Major facilitator Superfamily
A6K25_04810	COG2723	6-phospho-beta-galactosidase activity
A6K25_04840	COG1561	YicC-like family, N-terminal region
A6K25_04855	COG0425	Belongs to the sulfur carrier protein TusA family
A6K25_04905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6K25_04925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6K25_04935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6K25_04960	COG2911	Protein conserved in bacteria
A6K25_04965	COG0729	surface antigen
A6K25_04975	COG2814	Major facilitator Superfamily
A6K25_04985	COG0583	DNA-binding transcription factor activity
A6K25_04990	COG0606	chelatase, subunit chli
A6K25_05000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6K25_05005	COG0129	dihydroxy-acid dehydratase activity
A6K25_05035	COG1565	acr, cog1565
A6K25_05035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6K25_05040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6K25_05045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6K25_05070	COG1612	heme a metabolic process
A6K25_05075	COG0109	protoheme IX farnesyltransferase activity
A6K25_05080	COG1999	signal sequence binding
A6K25_05095	COG0534	Mate efflux family protein
A6K25_05100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A6K25_05115	COG1794	racemase activity, acting on amino acids and derivatives
A6K25_05135	COG1040	competence protein
A6K25_05140	COG0596	Alpha beta hydrolase
A6K25_05155	COG2183	response to ionizing radiation
A6K25_05160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6K25_05170	COG0545	Peptidyl-prolyl cis-trans isomerase
A6K25_05195	COG0488	(ABC) transporter
A6K25_05205	COG0429	hydrolase of the alpha beta-hydrolase fold
A6K25_05210	COG3089	Belongs to the UPF0270 family
A6K25_05220	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6K25_05235	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6K25_05240	COG0494	nUDIX hydrolase
A6K25_05245	COG1011	Hydrolase
A6K25_05255	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_05260	COG1234	tRNA 3'-trailer cleavage
A6K25_05270	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6K25_05285	COG4795	General secretion pathway protein
A6K25_05290	COG2165	general secretion pathway protein
A6K25_05300	COG2165	general secretion pathway protein
A6K25_05305	COG1459	type II secretion system
A6K25_05320	COG3031	protein transport across the cell outer membrane
A6K25_05330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6K25_05350	COG0745	RESPONSE REGULATOR receiver
A6K25_05365	COG2233	PERMEase
A6K25_05370	COG3954	Phosphoribulokinase
A6K25_05380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6K25_05390	COG0151	Belongs to the GarS family
A6K25_05405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6K25_05410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6K25_05425	COG0154	amidase activity
A6K25_05445	COG2176	DNA-directed DNA polymerase activity
A6K25_05465	COG0439	Biotin carboxylase
A6K25_05470	COG0511	ligase activity, forming carbon-carbon bonds
A6K25_05475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6K25_05480	COG0739	heme binding
A6K25_05485	COG4232	protein-disulfide reductase activity
A6K25_05515	COG0523	cobalamin synthesis protein
A6K25_05525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K25_05535	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6K25_05540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6K25_05545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6K25_05555	COG1166	arginine decarboxylase activity
A6K25_05565	COG4977	sequence-specific DNA binding
A6K25_05570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6K25_05575	COG0697	spore germination
A6K25_05590	COG1349	DNA-binding transcription factor activity
A6K25_05595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6K25_05620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6K25_05625	COG4771	TonB-dependent receptor
A6K25_05640	COG0523	cobalamin synthesis protein
A6K25_05660	COG4181	ATPase activity
A6K25_05670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6K25_05690	COG3706	GGDEF domain
A6K25_05690	COG5001	Diguanylate cyclase
A6K25_05690	COG4251	negative regulation of phosphorylation
A6K25_05690	COG2203	Gaf domain
A6K25_05695	COG2130	NADP-dependent
A6K25_05700	COG2067	long-chain fatty acid transport protein
A6K25_05725	COG1252	NADH dehydrogenase
A6K25_05730	COG2353	YceI-like domain
A6K25_05735	COG3038	cytochrome b561
A6K25_05760	COG2267	carboxylic ester hydrolase activity
A6K25_05810	COG3237	CsbD-like
A6K25_05850	COG4319	ketosteroid isomerase
A6K25_05875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6K25_05910	COG2204	response regulator
A6K25_05925	COG1294	oxidase, subunit
A6K25_05935	COG4988	ABC transporter
A6K25_05940	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6K25_05945	COG4771	TonB-dependent receptor
A6K25_05980	COG1230	cation diffusion facilitator family transporter
A6K25_05985	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_06005	COG0656	L-ascorbic acid biosynthetic process
A6K25_06010	COG2175	clavaminate synthase activity
A6K25_06015	COG2855	membrane
A6K25_06030	COG1472	Belongs to the glycosyl hydrolase 3 family
A6K25_06040	COG4206	TonB-dependent receptor
A6K25_06050	COG4558	Periplasmic binding protein
A6K25_06055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6K25_06060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6K25_06070	COG2723	6-phospho-beta-galactosidase activity
A6K25_06075	COG2211	Major facilitator Superfamily
A6K25_06080	COG1609	Transcriptional regulator
A6K25_06090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_06090	COG4191	Histidine kinase
A6K25_06095	COG0840	transmembrane signaling receptor activity
A6K25_06105	COG5002	protein histidine kinase activity
A6K25_06135	COG2258	MOSC domain
A6K25_06160	COG0305	Participates in initiation and elongation during chromosome replication
A6K25_06170	COG0432	Pfam Uncharacterised protein family UPF0047
A6K25_06180	COG0735	belongs to the Fur family
A6K25_06185	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6K25_06190	COG2816	NAD+ diphosphatase activity
A6K25_06195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6K25_06205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6K25_06210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6K25_06210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6K25_06215	COG0802	atpase or kinase
A6K25_06230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6K25_06235	COG1923	regulation of RNA biosynthetic process
A6K25_06240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6K25_06245	COG0330	HflC and HflK could
A6K25_06250	COG0330	HflC and HflK could
A6K25_06255	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6K25_06260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6K25_06275	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_06285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6K25_06290	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6K25_06305	COG0625	glutathione transferase activity
A6K25_06320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_06330	COG1793	dna ligase
A6K25_06340	COG1201	RNA secondary structure unwinding
A6K25_06345	COG3306	glycosyltransferase involved in LPS biosynthesis
A6K25_06360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6K25_06365	COG2957	Belongs to the agmatine deiminase family
A6K25_06385	COG0302	gtp cyclohydrolase
A6K25_06400	COG0346	lactoylglutathione lyase activity
A6K25_06405	COG4989	oxidoreductase activity
A6K25_06410	COG3040	lipid binding
A6K25_06420	COG0418	dihydroorotase activity
A6K25_06425	COG0513	Belongs to the DEAD box helicase family
A6K25_06435	COG3590	peptidase
A6K25_06440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6K25_06445	COG1132	(ABC) transporter
A6K25_06455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6K25_06460	COG0250	Participates in transcription elongation, termination and antitermination
A6K25_06465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6K25_06470	COG0081	regulation of translation
A6K25_06475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6K25_06480	COG0222	ribosome binding
A6K25_06485	COG0085	RNA polymerase activity
A6K25_06490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6K25_06495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6K25_06500	COG0049	tRNA binding
A6K25_06505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6K25_06540	COG1252	NADH dehydrogenase
A6K25_06565	COG1966	Carbon starvation protein
A6K25_06570	COG0701	Predicted permease
A6K25_06575	COG1253	flavin adenine dinucleotide binding
A6K25_06595	COG4774	siderophore transport
A6K25_06600	COG2205	protein histidine kinase activity
A6K25_06605	COG0745	RESPONSE REGULATOR receiver
A6K25_06610	COG1131	(ABC) transporter
A6K25_06615	COG0842	Transport permease protein
A6K25_06625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6K25_06630	COG0076	glutamate decarboxylase activity
A6K25_06645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6K25_06655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6K25_06660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6K25_06680	COG2095	MarC family integral membrane protein
A6K25_06690	COG0742	ribosomal rna small subunit methyltransferase
A6K25_06695	COG0552	protein localization to endoplasmic reticulum
A6K25_06700	COG2884	Cell division ATP-binding protein ftsE
A6K25_06705	COG2177	Part of the ABC transporter FtsEX involved in
A6K25_06710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6K25_06715	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6K25_06725	COG0456	acetyltransferase
A6K25_06755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6K25_06760	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6K25_06765	COG0281	malic enzyme
A6K25_06780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6K25_06785	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6K25_06790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6K25_06830	COG0793	Belongs to the peptidase S41A family
A6K25_06830	COG4946	Tricorn protease homolog
A6K25_06835	COG0243	molybdopterin cofactor binding
A6K25_06840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6K25_06850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_06850	COG4191	Histidine kinase
A6K25_06860	COG2201	protein-glutamate methylesterase activity
A6K25_06865	COG0339	signal peptide processing
A6K25_06885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6K25_06890	COG1278	Cold shock
A6K25_06905	COG1522	sequence-specific DNA binding
A6K25_06910	COG0840	transmembrane signaling receptor activity
A6K25_06915	COG1294	oxidase, subunit
A6K25_06920	COG1271	oxidase subunit
A6K25_06940	COG2234	aminopeptidase activity
A6K25_06945	COG0543	2 iron, 2 sulfur cluster binding
A6K25_06960	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6K25_06975	COG0557	exoribonuclease II activity
A6K25_07030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6K25_07050	COG0201	protein transport
A6K25_07070	COG0202	RNA polymerase activity
A6K25_07080	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6K25_07080	COG0662	Cupin 2, conserved barrel domain protein
A6K25_07100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6K25_07105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6K25_07175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6K25_07180	COG0463	Glycosyl transferase, family 2
A6K25_07185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6K25_07215	COG0438	transferase activity, transferring glycosyl groups
A6K25_07215	COG1216	Glycosyl transferase, family 2
A6K25_07230	COG0583	DNA-binding transcription factor activity
A6K25_07290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6K25_07295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6K25_07295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6K25_07300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6K25_07335	COG0753	catalase activity
A6K25_07350	COG0667	Aldo Keto reductase
A6K25_07355	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6K25_07370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6K25_07385	COG0189	ligase activity
A6K25_07385	COG4067	protein conserved in archaea
A6K25_07395	COG0189	ligase activity
A6K25_07415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_07420	COG0517	IMP dehydrogenase activity
A6K25_07420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6K25_07430	COG0745	RESPONSE REGULATOR receiver
A6K25_07430	COG3706	GGDEF domain
A6K25_07440	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6K25_07455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6K25_07460	COG0572	uridine kinase
A6K25_07490	COG1438	arginine binding
A6K25_07495	COG0039	L-malate dehydrogenase activity
A6K25_07505	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6K25_07510	COG0545	Peptidyl-prolyl cis-trans isomerase
A6K25_07515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6K25_07525	COG1805	sodium ion transport
A6K25_07530	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6K25_07535	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6K25_07540	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6K25_07545	COG2871	sodium ion transport
A6K25_07550	COG1477	protein flavinylation
A6K25_07560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6K25_07570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_07585	COG1522	sequence-specific DNA binding
A6K25_07600	COG0121	glutamine amidotransferase
A6K25_07605	COG0583	DNA-binding transcription factor activity
A6K25_07615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_07620	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6K25_07630	COG5001	Diguanylate cyclase
A6K25_07630	COG5002	protein histidine kinase activity
A6K25_07645	COG0702	epimerase
A6K25_07650	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6K25_07680	COG0457	Tetratricopeptide repeat
A6K25_07690	COG0848	biopolymer transport protein
A6K25_07700	COG0716	FMN binding
A6K25_07715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6K25_07730	COG0733	neurotransmitter:sodium symporter activity
A6K25_07735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6K25_07750	COG0668	transmembrane transport
A6K25_07755	COG0204	Acyl-transferase
A6K25_07760	COG0204	Acyl-transferase
A6K25_07765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6K25_07790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6K25_07800	COG1842	Phage shock protein A
A6K25_07825	COG4771	TonB-dependent receptor
A6K25_07830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6K25_07850	COG3300	MHYT domain
A6K25_07850	COG5001	Diguanylate cyclase
A6K25_07855	COG1573	uracil-dna glycosylase
A6K25_07865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6K25_07880	COG1309	transcriptional regulator
A6K25_07930	COG0417	DNA replication proofreading
A6K25_07940	COG4191	Histidine kinase
A6K25_07960	COG0730	response to heat
A6K25_07975	COG3568	Endonuclease Exonuclease Phosphatase
A6K25_08010	COG3264	Mechanosensitive ion channel
A6K25_08010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6K25_08020	COG2186	Transcriptional regulator
A6K25_08025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_08030	COG0800	Aldolase
A6K25_08035	COG0513	Belongs to the DEAD box helicase family
A6K25_08040	COG1716	ATPase activity
A6K25_08040	COG1131	(ABC) transporter
A6K25_08040	COG0842	Transport permease protein
A6K25_08060	COG0515	serine threonine protein kinase
A6K25_08060	COG1357	PFAM Pentapeptide repeats (8 copies)
A6K25_08095	COG1716	ATPase activity
A6K25_08115	COG2271	Major facilitator Superfamily
A6K25_08120	COG1917	Cupin 2, conserved barrel domain protein
A6K25_08130	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_08160	COG1858	cytochrome C peroxidase
A6K25_08165	COG4771	TonB-dependent receptor
A6K25_08195	COG4585	Histidine kinase
A6K25_08200	COG2197	response regulator
A6K25_08205	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_08210	COG3901	Regulator of nitric oxide reductase transcription
A6K25_08210	COG0348	domain, Protein
A6K25_08220	COG2205	protein histidine kinase activity
A6K25_08220	COG0784	Response regulator, receiver
A6K25_08250	COG0535	radical SAM domain protein
A6K25_08260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A6K25_08265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6K25_08270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6K25_08310	COG3706	GGDEF domain
A6K25_08315	COG3706	GGDEF domain
A6K25_08345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_08355	COG4191	Histidine kinase
A6K25_08415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6K25_08495	COG1082	Xylose isomerase domain protein TIM barrel
A6K25_08505	COG0318	PFAM AMP-dependent synthetase and ligase
A6K25_08515	COG4264	IucA IucC family
A6K25_08565	COG0795	lipopolysaccharide-transporting ATPase activity
A6K25_08570	COG0795	lipopolysaccharide-transporting ATPase activity
A6K25_08575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6K25_08580	COG2927	DNA polymerase III (CHI subunit)
A6K25_08585	COG0525	valine-tRNA ligase activity
A6K25_08600	COG3706	GGDEF domain
A6K25_08615	COG0204	Acyl-transferase
A6K25_08620	COG3437	response regulator, receiver
A6K25_08630	COG3852	Histidine kinase
A6K25_08640	COG0174	glutamine synthetase
A6K25_08655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6K25_08660	COG1914	H( )-stimulated, divalent metal cation uptake system
A6K25_08700	COG0850	regulation of cytokinetic process
A6K25_08705	COG2894	cell division
A6K25_08725	COG0625	glutathione transferase activity
A6K25_08730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6K25_08740	COG1902	pentaerythritol trinitrate reductase activity
A6K25_08745	COG3659	wide pore channel activity
A6K25_08750	COG0738	Major facilitator superfamily
A6K25_08770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6K25_08775	COG0739	heme binding
A6K25_08795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6K25_08810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6K25_08825	COG3866	Pectate lyase
A6K25_08845	COG3866	Pectate lyase
A6K25_08850	COG1476	TRANSCRIPTIONal
A6K25_08860	COG0493	'glutamate synthase
A6K25_08865	COG0069	glutamate synthase activity
A6K25_08865	COG0070	glutamate synthase
A6K25_08865	COG0067	glutamate synthase
A6K25_08870	COG5002	protein histidine kinase activity
A6K25_08870	COG2198	Histidine kinase
A6K25_08870	COG0784	Response regulator, receiver
A6K25_08915	COG2203	Gaf domain
A6K25_08915	COG2199	diguanylate cyclase activity
A6K25_08920	COG2828	Protein conserved in bacteria
A6K25_08930	COG0372	Belongs to the citrate synthase family
A6K25_08935	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6K25_08945	COG4771	TonB-dependent receptor
A6K25_08950	COG2197	response regulator
A6K25_08955	COG4585	Histidine kinase
A6K25_09000	COG2823	Periplasmic or secreted lipoprotein
A6K25_09010	COG0792	nuclease activity
A6K25_09015	COG3107	peptidoglycan biosynthetic process
A6K25_09020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6K25_09035	COG1748	Saccharopine dehydrogenase
A6K25_09065	COG5002	protein histidine kinase activity
A6K25_09070	COG0745	RESPONSE REGULATOR receiver
A6K25_09075	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A6K25_09080	COG2201	protein-glutamate methylesterase activity
A6K25_09085	COG0798	PFAM Bile acid sodium symporter
A6K25_09090	COG0431	NADPH-dependent FMN reductase
A6K25_09100	COG0640	Transcriptional regulator
A6K25_09120	COG4585	Histidine kinase
A6K25_09125	COG2197	response regulator
A6K25_09135	COG0583	DNA-binding transcription factor activity
A6K25_09145	COG0083	homoserine kinase activity
A6K25_09175	COG0625	glutathione transferase activity
A6K25_09180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_09195	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6K25_09195	COG1902	pentaerythritol trinitrate reductase activity
A6K25_09210	COG0762	integral membrane protein
A6K25_09215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6K25_09220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6K25_09240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6K25_09245	COG1678	Uncharacterized ACR, COG1678
A6K25_09250	COG0189	ligase activity
A6K25_09255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6K25_09260	COG0668	transmembrane transport
A6K25_09280	COG0784	Response regulator, receiver
A6K25_09280	COG2198	Histidine kinase
A6K25_09280	COG5002	protein histidine kinase activity
A6K25_09285	COG2204	response regulator
A6K25_09295	COG5001	Diguanylate cyclase
A6K25_09295	COG2203	Gaf domain
A6K25_09295	COG4251	negative regulation of phosphorylation
A6K25_09295	COG3706	GGDEF domain
A6K25_09300	COG0678	peroxiredoxin activity
A6K25_09300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6K25_09340	COG2001	Belongs to the MraZ family
A6K25_09350	COG3116	cell division
A6K25_09355	COG0768	penicillin binding
A6K25_09360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6K25_09365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6K25_09375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6K25_09380	COG0772	Belongs to the SEDS family
A6K25_09390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6K25_09395	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6K25_09400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6K25_09405	COG0849	cell division
A6K25_09415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6K25_09420	COG0739	heme binding
A6K25_09430	COG0494	nUDIX hydrolase
A6K25_09435	COG2988	succinylglutamate desuccinylase activity
A6K25_09445	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6K25_09450	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6K25_09450	COG0237	dephospho-CoA kinase activity
A6K25_09460	COG1459	type II secretion system
A6K25_09465	COG4969	Belongs to the N-Me-Phe pilin family
A6K25_09490	COG2186	Transcriptional regulator
A6K25_09495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6K25_09500	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6K25_09505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6K25_09545	COG3313	Fe-S protein
A6K25_09565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6K25_09570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6K25_09575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6K25_09585	COG1957	nucleoside hydrolase
A6K25_09590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_09605	COG0006	proline dipeptidase activity
A6K25_09610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6K25_09615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6K25_09640	COG1629	transport
A6K25_09640	COG4206	TonB-dependent receptor
A6K25_09650	COG0477	Major facilitator Superfamily
A6K25_09655	COG1621	beta-fructofuranosidase activity
A6K25_09675	COG0583	DNA-binding transcription factor activity
A6K25_09715	COG1715	Restriction endonuclease
A6K25_09765	COG0656	L-ascorbic acid biosynthetic process
A6K25_09775	COG2814	Major facilitator Superfamily
A6K25_09825	COG0513	Belongs to the DEAD box helicase family
A6K25_09830	COG0697	spore germination
A6K25_09840	COG2133	pyrroloquinoline quinone binding
A6K25_09875	COG0653	protein targeting
A6K25_09890	COG1451	nucleotide metabolic process
A6K25_09910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6K25_09925	COG4249	Peptidase C14 caspase catalytic subunit p20
A6K25_09925	COG2319	Wd-40 repeat
A6K25_09950	COG3604	Transcriptional regulator
A6K25_09965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6K25_09965	COG1017	nitric oxide dioxygenase activity
A6K25_09970	COG0484	heat shock protein binding
A6K25_09980	COG0583	DNA-binding transcription factor activity
A6K25_10000	COG4681	YaeQ
A6K25_10005	COG0514	ATP-dependent DNA helicase (RecQ)
A6K25_10015	COG1295	ribonuclease BN
A6K25_10025	COG1846	Transcriptional regulator
A6K25_10030	COG1566	PFAM secretion protein HlyD family protein
A6K25_10065	COG4771	TonB-dependent receptor
A6K25_10085	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A6K25_10090	COG1335	isochorismatase
A6K25_10095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6K25_10130	COG0789	Transcriptional regulator
A6K25_10135	COG1230	cation diffusion facilitator family transporter
A6K25_10175	COG2963	transposase activity
A6K25_10180	COG2801	Transposase and inactivated derivatives
A6K25_10200	COG0693	protein deglycase activity
A6K25_10205	COG4221	oxidoreductase activity
A6K25_10220	COG0583	DNA-binding transcription factor activity
A6K25_10235	COG0109	protoheme IX farnesyltransferase activity
A6K25_10250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6K25_10255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6K25_10265	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_10300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6K25_10315	COG1733	regulation of RNA biosynthetic process
A6K25_10320	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_10335	COG0583	DNA-binding transcription factor activity
A6K25_10400	COG0826	peptidase U32
A6K25_10405	COG1607	acyl-coa hydrolase
A6K25_10455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6K25_10465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6K25_10495	COG1960	acyl-CoA dehydrogenase activity
A6K25_10535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6K25_10550	COG0189	ligase activity
A6K25_10565	COG0789	Transcriptional regulator
A6K25_10570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6K25_10600	COG1609	Transcriptional regulator
A6K25_10625	COG4682	membrane
A6K25_10630	COG1629	transport
A6K25_10630	COG4774	siderophore transport
A6K25_10645	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_10660	COG4774	siderophore transport
A6K25_10690	COG0515	serine threonine protein kinase
A6K25_10715	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6K25_10720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6K25_10725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6K25_10730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6K25_10770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6K25_10775	COG1609	Transcriptional regulator
A6K25_10785	COG1435	thymidine kinase activity
A6K25_10800	COG1960	acyl-CoA dehydrogenase activity
A6K25_10830	COG1560	Kdo2-lipid A biosynthetic process
A6K25_10850	COG2827	Endonuclease containing a URI domain
A6K25_10855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6K25_10855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6K25_10860	COG3267	Type II secretory pathway component ExeA
A6K25_10860	COG3409	Peptidoglycan-binding domain 1 protein
A6K25_10870	COG0489	protein tyrosine kinase activity
A6K25_10905	COG1216	Glycosyl transferase, family 2
A6K25_10905	COG0463	Glycosyl transferase, family 2
A6K25_10950	COG0438	transferase activity, transferring glycosyl groups
A6K25_10975	COG1045	serine acetyltransferase
A6K25_10980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6K25_11035	COG1785	Belongs to the alkaline phosphatase family
A6K25_11040	COG2066	Belongs to the glutaminase family
A6K25_11055	COG0754	glutathionylspermidine amidase activity
A6K25_11080	COG1842	Phage shock protein A
A6K25_11085	COG3789	protein conserved in bacteria
A6K25_11100	COG0343	queuine tRNA-ribosyltransferase activity
A6K25_11105	COG1862	Preprotein translocase
A6K25_11110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K25_11115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K25_11145	COG0483	inositol monophosphate 1-phosphatase activity
A6K25_11150	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6K25_11165	COG1104	cysteine desulfurase activity
A6K25_11170	COG0719	Fe-S assembly protein
A6K25_11175	COG0396	ATPase activity
A6K25_11180	COG0719	Fe-S assembly protein
A6K25_11185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6K25_11200	COG2166	iron-sulfur cluster assembly
A6K25_11210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6K25_11235	COG2976	Protein conserved in bacteria
A6K25_11240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6K25_11255	COG1570	exodeoxyribonuclease VII activity
A6K25_11260	COG0516	GMP reductase activity
A6K25_11260	COG0517	IMP dehydrogenase activity
A6K25_11280	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6K25_11285	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A6K25_11300	COG1720	tRNA m6t6A37 methyltransferase activity
A6K25_11340	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6K25_11345	COG0740	serine-type endopeptidase activity
A6K25_11350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6K25_11355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6K25_11360	COG0776	regulation of translation
A6K25_11365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K25_11390	COG0385	Bile acid
A6K25_11395	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_11410	COG0268	Binds directly to 16S ribosomal RNA
A6K25_11415	COG0728	peptidoglycan biosynthetic process
A6K25_11420	COG0196	riboflavin kinase activity
A6K25_11425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6K25_11435	COG1047	Peptidyl-prolyl cis-trans
A6K25_11440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6K25_11500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6K25_11520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6K25_11535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6K25_11540	COG1595	DNA-templated transcription, initiation
A6K25_11565	COG0681	Belongs to the peptidase S26 family
A6K25_11585	COG0084	hydrolase, TatD family'
A6K25_11595	COG0560	Phosphoserine phosphatase
A6K25_11605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6K25_11615	COG0488	(ABC) transporter
A6K25_11620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6K25_11635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6K25_11635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6K25_11650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6K25_11660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6K25_11665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6K25_11675	COG0142	geranyltranstransferase activity
A6K25_11680	COG1722	exodeoxyribonuclease VII activity
A6K25_11685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6K25_11695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6K25_11710	COG4221	oxidoreductase activity
A6K25_11725	COG1595	DNA-templated transcription, initiation
A6K25_11740	COG0564	pseudouridine synthase activity
A6K25_11750	COG0542	response to heat
A6K25_11770	COG1183	phosphatidylcholine synthase activity
A6K25_11810	COG5001	Diguanylate cyclase
A6K25_11810	COG3706	GGDEF domain
A6K25_11810	COG4251	negative regulation of phosphorylation
A6K25_11810	COG2203	Gaf domain
A6K25_11825	COG2319	Wd-40 repeat
A6K25_11825	COG4249	Peptidase C14 caspase catalytic subunit p20
A6K25_11835	COG3220	belongs to the UPF0276 family
A6K25_11845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6K25_11850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6K25_11875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6K25_11880	COG0326	Molecular chaperone. Has ATPase activity
A6K25_11905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_11910	COG0745	RESPONSE REGULATOR receiver
A6K25_11915	COG0642	Histidine kinase
A6K25_11955	COG1022	Amp-dependent synthetase and ligase
A6K25_11965	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_11975	COG0140	phosphoribosyl-ATP diphosphatase activity
A6K25_11975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6K25_11990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6K25_11995	COG0131	Imidazoleglycerol-phosphate dehydratase
A6K25_11995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6K25_12000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6K25_12005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6K25_12010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6K25_12070	COG1199	ATP-dependent helicase activity
A6K25_12075	COG1214	PFAM Peptidase M22, glycoprotease
A6K25_12090	COG2267	carboxylic ester hydrolase activity
A6K25_12095	COG0318	PFAM AMP-dependent synthetase and ligase
A6K25_12100	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6K25_12115	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6K25_12120	COG2983	Belongs to the UPF0260 family
A6K25_12125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6K25_12130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6K25_12140	COG2186	Transcriptional regulator
A6K25_12175	COG4399	Belongs to the UPF0754 family
A6K25_12180	COG1309	transcriptional regulator
A6K25_12185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6K25_12210	COG1902	pentaerythritol trinitrate reductase activity
A6K25_12210	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6K25_12275	COG3101	peptidyl-lysine hydroxylation
A6K25_12305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6K25_12305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6K25_12330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6K25_12345	COG0101	tRNA pseudouridine synthase activity
A6K25_12360	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6K25_12365	COG1286	toxin biosynthetic process
A6K25_12370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6K25_12385	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6K25_12395	COG0604	alcohol dehydrogenase
A6K25_12405	COG2080	2 iron, 2 sulfur cluster binding
A6K25_12410	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6K25_12415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6K25_12420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K25_12440	COG2268	Band 7 protein
A6K25_12455	COG1785	Belongs to the alkaline phosphatase family
A6K25_12460	COG1785	Belongs to the alkaline phosphatase family
A6K25_12470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6K25_12490	COG0741	lytic transglycosylase activity
A6K25_12490	COG1388	LysM domain
A6K25_12495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_12500	COG2226	methyltransferase
A6K25_12505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_12505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_12510	COG0489	protein tyrosine kinase activity
A6K25_12520	COG0471	metal ion transport
A6K25_12540	COG0778	Nitroreductase
A6K25_12560	COG0330	HflC and HflK could
A6K25_12570	COG0753	catalase activity
A6K25_12580	COG0840	transmembrane signaling receptor activity
A6K25_12610	COG0738	Major facilitator superfamily
A6K25_12645	COG5002	protein histidine kinase activity
A6K25_12645	COG3850	Histidine kinase
A6K25_12650	COG0745	RESPONSE REGULATOR receiver
A6K25_12660	COG3706	GGDEF domain
A6K25_12675	COG1764	response to oxidative stress
A6K25_12680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6K25_12690	COG0746	molybdenum cofactor guanylyltransferase activity
A6K25_12720	COG0673	inositol 2-dehydrogenase activity
A6K25_12725	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_12730	COG1609	Transcriptional regulator
A6K25_12750	COG1024	Enoyl-CoA hydratase
A6K25_12760	COG2356	endonuclease I
A6K25_12780	COG4677	pectinesterase activity
A6K25_12790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6K25_12800	COG2755	lipolytic protein G-D-S-L family
A6K25_12805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_12810	COG0246	Mannitol dehydrogenase
A6K25_12815	COG1904	glucuronate isomerase
A6K25_12820	COG2721	sulfolactate sulfo-lyase activity
A6K25_12845	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6K25_12850	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_12860	COG3665	Urea carboxylase-associated protein
A6K25_12885	COG0745	RESPONSE REGULATOR receiver
A6K25_12890	COG2205	protein histidine kinase activity
A6K25_12935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6K25_12940	COG0469	pyruvate kinase activity
A6K25_12945	COG1737	Transcriptional regulator
A6K25_12950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6K25_12960	COG0129	dihydroxy-acid dehydratase activity
A6K25_12970	COG0800	Aldolase
A6K25_12975	COG0676	glucose-6-phosphate 1-epimerase activity
A6K25_12985	COG1640	4-alpha-glucanotransferase
A6K25_12990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6K25_13000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6K25_13020	COG2866	Carboxypeptidase
A6K25_13025	COG1115	amino acid carrier protein
A6K25_13035	COG3139	Protein of unknown function (DUF1315)
A6K25_13060	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6K25_13090	COG0784	Response regulator, receiver
A6K25_13095	COG4251	negative regulation of phosphorylation
A6K25_13105	COG2204	response regulator
A6K25_13115	COG0583	DNA-binding transcription factor activity
A6K25_13125	COG0640	Transcriptional regulator
A6K25_13145	COG0583	DNA-binding transcription factor activity
A6K25_13170	COG3300	MHYT domain
A6K25_13170	COG5001	Diguanylate cyclase
A6K25_13175	COG1022	Amp-dependent synthetase and ligase
A6K25_13185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6K25_13190	COG1074	ATP-dependent DNA helicase activity
A6K25_13195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6K25_13210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6K25_13225	COG3268	Saccharopine dehydrogenase
A6K25_13230	COG0436	Aminotransferase
A6K25_13265	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_13475	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_13540	COG0666	response to abiotic stimulus
A6K25_13585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6K25_13590	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6K25_13595	COG0315	cyclic pyranopterin monophosphate synthase activity
A6K25_13600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6K25_13605	COG0314	molybdopterin synthase activity
A6K25_13620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6K25_13625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6K25_13645	COG4771	TonB-dependent receptor
A6K25_13655	COG1960	acyl-CoA dehydrogenase activity
A6K25_13685	COG0596	Alpha beta hydrolase
A6K25_13690	COG1024	Enoyl-CoA hydratase
A6K25_13690	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6K25_13695	COG0183	Belongs to the thiolase family
A6K25_13700	COG1960	acyl-CoA dehydrogenase activity
A6K25_13705	COG0596	Alpha beta hydrolase
A6K25_13720	COG2390	Transcriptional regulator
A6K25_13725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_13735	COG0246	Mannitol dehydrogenase
A6K25_13755	COG0668	transmembrane transport
A6K25_13775	COG0668	transmembrane transport
A6K25_13780	COG4771	TonB-dependent receptor
A6K25_13800	COG0784	Response regulator, receiver
A6K25_13800	COG2205	protein histidine kinase activity
A6K25_13800	COG2198	Histidine kinase
A6K25_13805	COG3437	response regulator, receiver
A6K25_13815	COG0195	Participates in both transcription termination and antitermination
A6K25_13830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6K25_13840	COG4269	membrane
A6K25_13850	COG3706	GGDEF domain
A6K25_13855	COG0596	Alpha beta hydrolase
A6K25_13865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6K25_13865	COG3153	acetyltransferase
A6K25_13890	COG0450	alkyl hydroperoxide reductase
A6K25_13900	COG4774	siderophore transport
A6K25_13925	COG1032	radical SAM domain protein
A6K25_13940	COG4771	TonB-dependent receptor
A6K25_13955	COG4134	Bacterial extracellular solute-binding protein
A6K25_13960	COG4135	transport system, permease component
A6K25_13965	COG4136	ATPase activity
A6K25_13970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6K25_13985	COG4251	negative regulation of phosphorylation
A6K25_13985	COG5001	Diguanylate cyclase
A6K25_13985	COG3706	GGDEF domain
A6K25_13985	COG2203	Gaf domain
A6K25_14010	COG4251	negative regulation of phosphorylation
A6K25_14010	COG3706	GGDEF domain
A6K25_14010	COG2203	Gaf domain
A6K25_14010	COG5001	Diguanylate cyclase
A6K25_14065	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_14095	COG2814	Major facilitator Superfamily
A6K25_14100	COG4771	TonB-dependent receptor
A6K25_14115	COG3311	Transcriptional regulator
A6K25_14145	COG0582	viral genome integration into host DNA
A6K25_14165	COG2867	negative regulation of translational initiation
A6K25_14170	COG2914	Belongs to the UPF0125 (RnfH) family
A6K25_14180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6K25_14190	COG0457	Tetratricopeptide repeat
A6K25_14195	COG2318	DinB family
A6K25_14200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6K25_14205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6K25_14210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6K25_14220	COG0356	it plays a direct role in the translocation of protons across the membrane
A6K25_14240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6K25_14260	COG0477	Major facilitator Superfamily
A6K25_14285	COG0295	cytidine deaminase activity
A6K25_14305	COG1196	nuclear chromosome segregation
A6K25_14315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6K25_14330	COG1132	(ABC) transporter
A6K25_14335	COG1663	tetraacyldisaccharide 4'-kinase activity
A6K25_14375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6K25_14380	COG0579	oxidoreductase
A6K25_14385	COG0435	Glutathione S-transferase
A6K25_14405	COG2009	succinate dehydrogenase
A6K25_14410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6K25_14415	COG1053	succinate dehydrogenase
A6K25_14425	COG0567	Dehydrogenase, E1 component
A6K25_14430	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6K25_14465	COG4667	esterase of the alpha-beta hydrolase superfamily
A6K25_14485	COG0366	Alpha amylase catalytic
A6K25_14500	COG1609	Transcriptional regulator
A6K25_14510	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_14515	COG2267	carboxylic ester hydrolase activity
A6K25_14525	COG0616	signal peptide processing
A6K25_14550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6K25_14555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6K25_14560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6K25_14565	COG0386	Belongs to the glutathione peroxidase family
A6K25_14570	COG2084	Dehydrogenase
A6K25_14580	COG1960	acyl-CoA dehydrogenase activity
A6K25_14585	COG1024	Enoyl-CoA hydratase
A6K25_14590	COG2226	methyltransferase
A6K25_14600	COG3083	sulfuric ester hydrolase activity
A6K25_14605	COG3082	Protein of unknown function (DUF1414)
A6K25_14610	COG3081	Nucleoid-associated protein
A6K25_14640	COG3275	phosphorelay sensor kinase activity
A6K25_14645	COG3279	Response regulator of the LytR AlgR family
A6K25_14650	COG0205	6-phosphofructokinase activity
A6K25_14660	COG2205	protein histidine kinase activity
A6K25_14660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_14755	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_14765	COG0513	Belongs to the DEAD box helicase family
A6K25_14770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A6K25_14775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6K25_14780	COG0583	DNA-binding transcription factor activity
A6K25_14800	COG1760	l-serine dehydratase
A6K25_14805	COG0494	nUDIX hydrolase
A6K25_14810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6K25_14820	COG1322	Protein conserved in bacteria
A6K25_14825	COG1404	Belongs to the peptidase S8 family
A6K25_14835	COG0022	dehydrogenase e1 component
A6K25_14845	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6K25_14850	COG0515	serine threonine protein kinase
A6K25_14855	COG1946	Acyl-CoA thioesterase
A6K25_14865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6K25_14875	COG1956	GAF domain-containing protein
A6K25_14890	COG0793	Belongs to the peptidase S41A family
A6K25_14895	COG0733	neurotransmitter:sodium symporter activity
A6K25_14905	COG0308	aminopeptidase N
A6K25_14935	COG2902	Dehydrogenase
A6K25_14940	COG0167	dihydroorotate dehydrogenase activity
A6K25_14965	COG3130	regulation of translation
A6K25_14970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6K25_14980	COG0415	Belongs to the DNA photolyase family
A6K25_14985	COG0415	Belongs to the DNA photolyase family
A6K25_14990	COG3046	protein related to deoxyribodipyrimidine photolyase
A6K25_15015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6K25_15020	COG0589	response to stress
A6K25_15030	COG0069	glutamate synthase activity
A6K25_15045	COG2193	ferroxidase activity
A6K25_15055	COG3278	Belongs to the heme-copper respiratory oxidase family
A6K25_15070	COG2010	Cytochrome c
A6K25_15080	COG2217	Heavy metal translocating P-type atpase
A6K25_15095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6K25_15105	COG0037	tRNA processing
A6K25_15110	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6K25_15130	COG1280	lysine exporter protein (LysE YggA)
A6K25_15135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6K25_15140	COG2897	thiosulfate sulfurtransferase activity
A6K25_15145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6K25_15210	COG0582	viral genome integration into host DNA
A6K25_15235	COG0322	excinuclease ABC activity
A6K25_15240	COG2197	response regulator
A6K25_15245	COG1741	Belongs to the pirin family
A6K25_15255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6K25_15285	COG0642	Histidine kinase
A6K25_15290	COG0745	RESPONSE REGULATOR receiver
A6K25_15315	COG0670	Belongs to the BI1 family
A6K25_15325	COG2923	Belongs to the DsrF TusC family
A6K25_15335	COG2920	part of a sulfur-relay system
A6K25_15340	COG0561	phosphatase activity
A6K25_15355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6K25_15360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6K25_15365	COG0531	amino acid
A6K25_15365	COG1674	ftsk spoiiie
A6K25_15375	COG0686	Belongs to the AlaDH PNT family
A6K25_15380	COG0284	orotidine-5'-phosphate decarboxylase activity
A6K25_15385	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6K25_15390	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6K25_15400	COG0776	regulation of translation
A6K25_15405	COG0539	negative regulation of cytoplasmic translation
A6K25_15410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6K25_15415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6K25_15420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6K25_15435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6K25_15440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6K25_15445	COG0633	Ferredoxin
A6K25_15450	COG5002	protein histidine kinase activity
A6K25_15480	COG0789	Transcriptional regulator
A6K25_15575	COG1131	(ABC) transporter
A6K25_15610	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6K25_15615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6K25_15625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6K25_15635	COG4783	chaperone-mediated protein folding
A6K25_15645	COG1393	Belongs to the ArsC family
A6K25_15685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6K25_15720	COG0572	uridine kinase
A6K25_15725	COG3769	mannosylglycerate metabolic process
A6K25_15730	COG1215	transferase activity, transferring glycosyl groups
A6K25_15740	COG0303	'Molybdopterin
A6K25_15745	COG0534	Mate efflux family protein
A6K25_15760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K25_15765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6K25_15775	COG0405	Gamma-glutamyltransferase
A6K25_15780	COG1024	Enoyl-CoA hydratase
A6K25_15815	COG1448	Aminotransferase
A6K25_15820	COG1671	Belongs to the UPF0178 family
A6K25_15825	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_15835	COG1960	acyl-CoA dehydrogenase activity
A6K25_15840	COG2207	Transcriptional regulator
A6K25_15840	COG1917	Cupin 2, conserved barrel domain protein
A6K25_15890	COG0596	Alpha beta hydrolase
A6K25_15900	COG0716	FMN binding
A6K25_15920	COG3265	gluconokinase activity
A6K25_15925	COG1609	Transcriptional regulator
A6K25_15935	COG1984	allophanate hydrolase subunit 2
A6K25_15945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6K25_15950	COG2996	Protein conserved in bacteria
A6K25_15955	COG1765	OsmC-like protein
A6K25_15960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_15985	COG0436	Aminotransferase
A6K25_15990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6K25_15995	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6K25_16005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6K25_16015	COG1238	metal cluster binding
A6K25_16060	COG4628	conserved protein (DUF2132)
A6K25_16070	COG0454	-acetyltransferase
A6K25_16075	COG1119	ATPase activity
A6K25_16085	COG1185	polyribonucleotide nucleotidyltransferase activity
A6K25_16110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_16150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6K25_16155	COG0149	triose-phosphate isomerase activity
A6K25_16160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6K25_16165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6K25_16170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K25_16175	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6K25_16180	COG1534	Rna-binding protein
A6K25_16190	COG1067	ATP-dependent peptidase activity
A6K25_16195	COG0495	leucyl-tRNA aminoacylation
A6K25_16205	COG1466	dna polymerase III delta subunit
A6K25_16210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6K25_16215	COG0799	negative regulation of ribosome biogenesis
A6K25_16220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6K25_16225	COG0768	penicillin binding
A6K25_16230	COG0772	Belongs to the SEDS family
A6K25_16235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6K25_16240	COG1686	Belongs to the peptidase S11 family
A6K25_16245	COG2921	Belongs to the UPF0250 family
A6K25_16250	COG0321	lipoyl(octanoyl) transferase activity
A6K25_16255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6K25_16265	COG0252	asparaginase activity
A6K25_16275	COG0778	Nitroreductase
A6K25_16290	COG0616	signal peptide processing
A6K25_16310	COG0492	ferredoxin-NADP+ reductase activity
A6K25_16315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6K25_16320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6K25_16325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6K25_16330	COG0542	response to heat
A6K25_16335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6K25_16340	COG1278	Cold shock
A6K25_16350	COG1187	pseudouridine synthase activity
A6K25_16355	COG0482	sulfurtransferase activity
A6K25_16360	COG2915	High frequency lysogenization protein hflD homolog
A6K25_16365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6K25_16380	COG2850	peptidyl-arginine hydroxylation
A6K25_16395	COG0247	lactate metabolic process
A6K25_16395	COG0277	FAD linked oxidase domain protein
A6K25_16400	COG3123	guanosine phosphorylase activity
A6K25_16405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6K25_16450	COG1695	Transcriptional regulator
A6K25_16465	COG1077	Cell shape determining protein MreB Mrl
A6K25_16490	COG3265	gluconokinase activity
A6K25_16500	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_16515	COG1609	Transcriptional regulator
A6K25_16520	COG0679	Auxin Efflux Carrier
A6K25_16540	COG0574	Belongs to the PEP-utilizing enzyme family
A6K25_16540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6K25_16560	COG1942	4-Oxalocrotonate Tautomerase
A6K25_16580	COG1714	RDD family
A6K25_16600	COG3706	GGDEF domain
A6K25_16600	COG0745	RESPONSE REGULATOR receiver
A6K25_16605	COG0702	epimerase
A6K25_16615	COG0084	hydrolase, TatD family'
A6K25_16620	COG0470	DNA polymerase III
A6K25_16630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6K25_16635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6K25_16640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6K25_16645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6K25_16660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6K25_16665	COG0416	fatty acid biosynthetic process
A6K25_16675	COG1399	metal-binding, possibly nucleic acid-binding protein
A6K25_16680	COG0424	maF-like protein
A6K25_16685	COG0546	phosphoglycolate phosphatase activity
A6K25_16695	COG1530	ribonuclease E activity
A6K25_16715	COG2153	protein acetylation
A6K25_16735	COG0625	glutathione transferase activity
A6K25_16750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6K25_16760	COG0583	DNA-binding transcription factor activity
A6K25_16770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6K25_16775	COG3724	N-succinylarginine dihydrolase activity
A6K25_16785	COG1301	dicarboxylic acid transport
A6K25_16790	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6K25_16795	COG1136	(ABC) transporter
A6K25_16800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6K25_16830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6K25_16835	COG0328	RNA-DNA hybrid ribonuclease activity
A6K25_16860	COG1643	Atp-dependent helicase
A6K25_16905	COG4999	Histidine kinase
A6K25_16905	COG2205	protein histidine kinase activity
A6K25_16905	COG3850	Histidine kinase
A6K25_16905	COG3437	response regulator, receiver
A6K25_16910	COG2925	Exonuclease
A6K25_16925	COG0183	Belongs to the thiolase family
A6K25_16930	COG0789	Transcriptional regulator
A6K25_16935	COG1960	acyl-CoA dehydrogenase activity
A6K25_16940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6K25_16945	COG1024	Enoyl-CoA hydratase
A6K25_16980	COG1957	nucleoside hydrolase
A6K25_16995	COG2814	Major facilitator Superfamily
A6K25_17030	COG0708	Exodeoxyribonuclease III
A6K25_17050	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6K25_17060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6K25_17070	COG2096	Adenosyltransferase
A6K25_17075	COG0471	metal ion transport
A6K25_17080	COG1472	Belongs to the glycosyl hydrolase 3 family
A6K25_17090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6K25_17105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_17105	COG0072	phenylalanine-tRNA ligase activity
A6K25_17120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6K25_17120	COG2755	lipolytic protein G-D-S-L family
A6K25_17160	COG2327	Polysaccharide pyruvyl transferase
A6K25_17180	COG1215	transferase activity, transferring glycosyl groups
A6K25_17195	COG0438	transferase activity, transferring glycosyl groups
A6K25_17230	COG4464	protein tyrosine phosphatase activity
A6K25_17235	COG0489	protein tyrosine kinase activity
A6K25_17240	COG1596	polysaccharide export
A6K25_17250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6K25_17270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6K25_17280	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_17310	COG0154	amidase activity
A6K25_17320	COG0730	response to heat
A6K25_17325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6K25_17340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6K25_17345	COG2233	PERMEase
A6K25_17360	COG2205	protein histidine kinase activity
A6K25_17360	COG0784	Response regulator, receiver
A6K25_17365	COG3706	GGDEF domain
A6K25_17365	COG0745	RESPONSE REGULATOR receiver
A6K25_17370	COG5001	Diguanylate cyclase
A6K25_17370	COG3300	MHYT domain
A6K25_17380	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6K25_17385	COG2252	PERMEase
A6K25_17400	COG1309	transcriptional regulator
A6K25_17410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6K25_17425	COG2351	hydroxyisourate hydrolase activity
A6K25_17430	COG0402	S-adenosylhomocysteine deaminase activity
A6K25_17440	COG5002	protein histidine kinase activity
A6K25_17440	COG5001	Diguanylate cyclase
A6K25_17440	COG3447	MASE1 domain protein
A6K25_17460	COG3706	GGDEF domain
A6K25_17475	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6K25_17495	COG2190	(PTS) system
A6K25_17495	COG2211	Major facilitator Superfamily
A6K25_17500	COG1393	Belongs to the ArsC family
A6K25_17530	COG2988	succinylglutamate desuccinylase activity
A6K25_17540	COG0058	SHG alpha-glucan phosphorylase activity
A6K25_17545	COG0033	Phosphoglucomutase
A6K25_17550	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6K25_17555	COG0714	Associated with various cellular activities
A6K25_17570	COG2116	formate transmembrane transporter activity
A6K25_17575	COG0515	serine threonine protein kinase
A6K25_17575	COG2815	serine threonine protein kinase
A6K25_17580	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A6K25_17605	COG0583	DNA-binding transcription factor activity
A6K25_17620	COG3094	Invasion gene expression up-regulator, SirB
A6K25_17625	COG0784	Response regulator, receiver
A6K25_17625	COG3437	response regulator, receiver
A6K25_17630	COG2890	protein-(glutamine-N5) methyltransferase activity
A6K25_17640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6K25_17645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6K25_17650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6K25_17660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6K25_17665	COG5001	Diguanylate cyclase
A6K25_17665	COG3300	MHYT domain
A6K25_17675	COG1064	alcohol dehydrogenase
A6K25_17690	COG0012	GTP binding
A6K25_17695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6K25_17720	COG1115	amino acid carrier protein
A6K25_17725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6K25_17740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6K25_17750	COG1702	phosphate starvation-inducible protein PhoH
A6K25_17760	COG4535	Mg2 and Co2 transporter CorC
A6K25_17765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6K25_17770	COG0857	belongs to the CobB CobQ family
A6K25_17770	COG0280	phosphate acetyltransferase
A6K25_17775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6K25_17780	COG0071	Belongs to the small heat shock protein (HSP20) family
A6K25_17805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6K25_17810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6K25_17815	COG0505	Belongs to the CarA family
A6K25_17820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6K25_17835	COG5001	Diguanylate cyclase
A6K25_17835	COG2203	Gaf domain
A6K25_17835	COG4251	negative regulation of phosphorylation
A6K25_17835	COG3706	GGDEF domain
A6K25_17840	COG3909	cytochrome
A6K25_17845	COG0484	heat shock protein binding
A6K25_17855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6K25_17860	COG2205	protein histidine kinase activity
A6K25_17860	COG0784	Response regulator, receiver
A6K25_17870	COG4771	TonB-dependent receptor
A6K25_17875	COG2610	gluconate transmembrane transporter activity
A6K25_17880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6K25_17890	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_17900	COG0497	DNA recombination
A6K25_17905	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6K25_17910	COG0500	methyltransferase
A6K25_17915	COG2733	membrane
A6K25_17930	COG0110	maltose O-acetyltransferase activity
A6K25_17935	COG0656	L-ascorbic acid biosynthetic process
A6K25_17950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6K25_17955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6K25_17960	COG0009	L-threonylcarbamoyladenylate synthase
A6K25_17965	COG0613	PHP domain protein
A6K25_17970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6K25_17980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6K25_17985	COG0134	indole-3-glycerol-phosphate synthase activity
A6K25_17985	COG0135	phosphoribosylanthranilate isomerase activity
A6K25_17995	COG0159	tryptophan synthase activity
A6K25_18000	COG2350	Protein conserved in bacteria
A6K25_18015	COG0745	RESPONSE REGULATOR receiver
A6K25_18020	COG2205	protein histidine kinase activity
A6K25_18025	COG0628	permease
A6K25_18030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6K25_18035	COG1090	epimerase
A6K25_18040	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6K25_18045	COG4181	ATPase activity
A6K25_18065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6K25_18105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6K25_18125	COG0745	RESPONSE REGULATOR receiver
A6K25_18135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6K25_18140	COG5265	(ABC) transporter
A6K25_18155	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6K25_18165	COG4139	cobalamin transport
A6K25_18170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6K25_18185	COG1073	alpha beta
A6K25_18185	COG2226	methyltransferase
A6K25_18190	COG0156	8-amino-7-oxononanoate synthase activity
A6K25_18215	COG0456	acetyltransferase
A6K25_18220	COG0189	ligase activity
A6K25_18235	COG0017	Asparaginyl-tRNA synthetase
A6K25_18245	COG2995	paraquat-inducible protein a
A6K25_18250	COG3008	intermembrane lipid transfer
A6K25_18250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6K25_18260	COG3706	GGDEF domain
A6K25_18280	COG0583	DNA-binding transcription factor activity
A6K25_18285	COG1309	transcriptional regulator
A6K25_18295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_18300	COG0517	IMP dehydrogenase activity
A6K25_18315	COG0583	DNA-binding transcription factor activity
A6K25_18320	COG3038	cytochrome b561
A6K25_18330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6K25_18360	COG2271	Major facilitator Superfamily
A6K25_18365	COG2205	protein histidine kinase activity
A6K25_18365	COG0784	Response regulator, receiver
A6K25_18405	COG0024	Methionine aminopeptidase
A6K25_18415	COG0745	RESPONSE REGULATOR receiver
A6K25_18415	COG3706	GGDEF domain
A6K25_18440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6K25_18460	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6K25_18465	COG2885	chlorophyll binding
A6K25_18470	COG0823	Involved in the tonB-independent uptake of proteins
A6K25_18485	COG0811	peptide transport
A6K25_18490	COG0824	Thioesterase
A6K25_18495	COG2255	four-way junction helicase activity
A6K25_18510	COG0494	nUDIX hydrolase
A6K25_18515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6K25_18530	COG2204	response regulator
A6K25_18540	COG2205	protein histidine kinase activity
A6K25_18560	COG3706	GGDEF domain
A6K25_18560	COG0745	RESPONSE REGULATOR receiver
A6K25_18570	COG0023	Translation Initiation Factor
A6K25_18575	COG0745	RESPONSE REGULATOR receiver
A6K25_18580	COG0077	Prephenate dehydratase
A6K25_18580	COG1605	Chorismate mutase
A6K25_18585	COG0840	transmembrane signaling receptor activity
A6K25_18590	COG1605	Chorismate mutase
A6K25_18590	COG0287	Prephenate dehydrogenase
A6K25_18595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6K25_18600	COG2860	membrane
A6K25_18615	COG0335	large ribosomal subunit rRNA binding
A6K25_18620	COG0336	Belongs to the RNA methyltransferase TrmD family
A6K25_18625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6K25_18630	COG0228	four-way junction DNA binding
A6K25_18650	COG1132	(ABC) transporter
A6K25_18655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_18665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6K25_18695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6K25_18700	COG4137	Cytochrome C assembly protein
A6K25_18705	COG4536	flavin adenine dinucleotide binding
A6K25_18715	COG2062	phosphohistidine phosphatase, SixA
A6K25_18720	COG1025	Belongs to the peptidase M16 family
A6K25_18735	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6K25_18735	COG1024	Enoyl-CoA hydratase
A6K25_18745	COG0714	Associated with various cellular activities
A6K25_18765	COG2304	oxidoreductase activity
A6K25_18790	COG3706	GGDEF domain
A6K25_18795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_18800	COG0175	sulfate reduction
A6K25_18805	COG0529	Catalyzes the synthesis of activated sulfate
A6K25_18820	COG0471	metal ion transport
A6K25_18820	COG3273	potassium ion transport
A6K25_18845	COG0367	asparagine synthase
A6K25_18855	COG0602	queuosine metabolic process
A6K25_18880	COG0556	nucleotide-excision repair
A6K25_18885	COG0534	Mate efflux family protein
A6K25_18900	COG4657	Part of a membrane complex involved in electron transport
A6K25_18905	COG2878	Part of a membrane complex involved in electron transport
A6K25_18910	COG4656	Part of a membrane complex involved in electron transport
A6K25_18915	COG4658	electron transport chain
A6K25_18925	COG4660	Part of a membrane complex involved in electron transport
A6K25_18930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6K25_18955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6K25_18960	COG0823	Involved in the tonB-independent uptake of proteins
A6K25_18960	COG1506	peptidase
A6K25_18960	COG4946	Tricorn protease homolog
A6K25_18985	COG1278	Cold shock
A6K25_18990	COG0346	lactoylglutathione lyase activity
A6K25_18995	COG0584	glycerophosphoryl diester phosphodiesterase
A6K25_19000	COG2885	chlorophyll binding
A6K25_19005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6K25_19010	COG0450	alkyl hydroperoxide reductase
A6K25_19035	COG4771	TonB-dependent receptor
A6K25_19040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6K25_19050	COG2766	serine protein kinase
A6K25_19060	COG2719	SpoVR family
A6K25_19080	COG2890	protein-(glutamine-N5) methyltransferase activity
A6K25_19110	COG1136	(ABC) transporter
A6K25_19135	COG0612	Peptidase, M16
A6K25_19145	COG0564	pseudouridine synthase activity
A6K25_19150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6K25_19155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6K25_19180	COG2175	clavaminate synthase activity
A6K25_19210	COG0583	DNA-binding transcription factor activity
A6K25_19225	COG0456	acetyltransferase
A6K25_19280	COG0848	biopolymer transport protein
A6K25_19285	COG0811	peptide transport
A6K25_19290	COG0811	peptide transport
A6K25_19330	COG0457	Tetratricopeptide repeat
A6K25_19355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6K25_19360	COG1522	sequence-specific DNA binding
A6K25_19365	COG0625	glutathione transferase activity
A6K25_19395	COG1842	Phage shock protein A
A6K25_19400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6K25_19405	COG0747	negative chemotaxis
A6K25_19410	COG4168	peptide transport system, permease
A6K25_19415	COG4171	peptide transport system, permease
A6K25_19420	COG4172	Belongs to the ABC transporter superfamily
A6K25_19425	COG4172	Belongs to the ABC transporter superfamily
A6K25_19430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6K25_19445	COG1607	acyl-coa hydrolase
A6K25_19485	COG3590	peptidase
A6K25_19490	COG1309	transcriptional regulator
A6K25_19500	COG0659	secondary active sulfate transmembrane transporter activity
A6K25_19505	COG0288	reversible hydration of carbon dioxide
A6K25_19510	COG0583	DNA-binding transcription factor activity
A6K25_19515	COG0583	DNA-binding transcription factor activity
A6K25_19525	COG0646	methionine synthase
A6K25_19525	COG1410	methionine synthase
A6K25_19530	COG0646	methionine synthase
A6K25_19530	COG1410	methionine synthase
A6K25_19545	COG0835	chemotaxis
A6K25_19555	COG1192	Involved in chromosome partitioning
A6K25_19565	COG0643	Histidine kinase
A6K25_19565	COG2198	Histidine kinase
A6K25_19570	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6K25_19585	COG0455	bacterial-type flagellum organization
A6K25_19595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6K25_19610	COG1987	bacterial-type flagellum assembly
A6K25_19660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6K25_19665	COG1766	The M ring may be actively involved in energy transduction
A6K25_19675	COG2204	response regulator
A6K25_19680	COG3852	Histidine kinase
A6K25_19685	COG2204	response regulator
A6K25_19695	COG1086	Polysaccharide biosynthesis protein
A6K25_19700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6K25_19705	COG1083	cytidylyl-transferase
A6K25_19715	COG2089	acid synthase
A6K25_19730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6K25_19775	COG2089	acid synthase
A6K25_19780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6K25_19785	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6K25_19825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6K25_19830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6K25_19850	COG1256	bacterial-type flagellum assembly
A6K25_19855	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6K25_19855	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6K25_19870	COG4786	Flagellar basal body rod
A6K25_19875	COG4787	bacterial-type flagellum-dependent cell motility
A6K25_19880	COG1749	Flagellar hook protein flgE
A6K25_19885	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6K25_19890	COG1558	bacterial-type flagellum-dependent cell motility
A6K25_19895	COG1815	bacterial-type flagellum-dependent cell motility
A6K25_19900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6K25_19905	COG0835	chemotaxis
A6K25_19905	COG0784	Response regulator, receiver
A6K25_19945	COG2197	response regulator
A6K25_19950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_19955	COG2274	protein secretion by the type I secretion system
A6K25_19960	COG2885	chlorophyll binding
A6K25_19970	COG2963	transposase activity
A6K25_19975	COG2801	Transposase and inactivated derivatives
A6K25_19990	COG2840	Smr protein MutS2
A6K25_19995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6K25_19995	COG0047	phosphoribosylformylglycinamidine synthase activity
A6K25_20005	COG0590	tRNA wobble adenosine to inosine editing
A6K25_20025	COG0037	tRNA processing
A6K25_20030	COG0825	malonyl-CoA metabolic process
A6K25_20035	COG0587	DNA-directed DNA polymerase activity
A6K25_20050	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6K25_20055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6K25_20070	COG0750	zinc metalloprotease
A6K25_20075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6K25_20080	COG0575	Belongs to the CDS family
A6K25_20085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6K25_20095	COG0528	UMP kinase activity
A6K25_20105	COG0052	Belongs to the universal ribosomal protein uS2 family
A6K25_20110	COG0024	Methionine aminopeptidase
A6K25_20130	COG0564	pseudouridine synthase activity
A6K25_20200	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6K25_20200	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6K25_20205	COG3706	GGDEF domain
A6K25_20205	COG0745	RESPONSE REGULATOR receiver
A6K25_20210	COG1611	Belongs to the LOG family
A6K25_20225	COG0473	3-isopropylmalate dehydrogenase activity
A6K25_20230	COG1596	polysaccharide export
A6K25_20230	COG1555	photosystem II stabilization
A6K25_20235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6K25_20265	COG1682	transport, permease protein
A6K25_20280	COG3104	oligopeptide transport
A6K25_20290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6K25_20295	COG2853	Lipoprotein