locus-tag	class	description
A6F57_00005	COG0513	Belongs to the DEAD box helicase family
A6F57_00015	COG3547	Transposase (IS116 IS110 IS902 family)
A6F57_00115	COG2205	protein histidine kinase activity
A6F57_00115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_00125	COG0205	6-phosphofructokinase activity
A6F57_00130	COG3279	Response regulator of the LytR AlgR family
A6F57_00135	COG3275	phosphorelay sensor kinase activity
A6F57_00165	COG3081	Nucleoid-associated protein
A6F57_00170	COG3082	Protein of unknown function (DUF1414)
A6F57_00175	COG3083	sulfuric ester hydrolase activity
A6F57_00185	COG2226	methyltransferase
A6F57_00190	COG1024	Enoyl-CoA hydratase
A6F57_00195	COG1960	acyl-CoA dehydrogenase activity
A6F57_00205	COG2084	Dehydrogenase
A6F57_00210	COG0386	Belongs to the glutathione peroxidase family
A6F57_00215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F57_00220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F57_00225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6F57_00250	COG0616	signal peptide processing
A6F57_00260	COG2267	carboxylic ester hydrolase activity
A6F57_00265	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_00275	COG1609	Transcriptional regulator
A6F57_00290	COG0366	Alpha amylase catalytic
A6F57_00310	COG4667	esterase of the alpha-beta hydrolase superfamily
A6F57_00345	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F57_00350	COG0567	Dehydrogenase, E1 component
A6F57_00360	COG1053	succinate dehydrogenase
A6F57_00365	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6F57_00370	COG2009	succinate dehydrogenase
A6F57_00390	COG0435	Glutathione S-transferase
A6F57_00395	COG0579	oxidoreductase
A6F57_00400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6F57_00440	COG1663	tetraacyldisaccharide 4'-kinase activity
A6F57_00445	COG1132	(ABC) transporter
A6F57_00460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6F57_00470	COG1196	nuclear chromosome segregation
A6F57_00490	COG0295	cytidine deaminase activity
A6F57_00515	COG0477	Major facilitator Superfamily
A6F57_00535	COG2318	DinB family
A6F57_00540	COG0457	Tetratricopeptide repeat
A6F57_00550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6F57_00560	COG2914	Belongs to the UPF0125 (RnfH) family
A6F57_00565	COG2867	negative regulation of translational initiation
A6F57_00585	COG0582	viral genome integration into host DNA
A6F57_00620	COG3311	Transcriptional regulator
A6F57_00640	COG4771	TonB-dependent receptor
A6F57_00645	COG2814	Major facilitator Superfamily
A6F57_00675	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_00685	COG1595	DNA-templated transcription, initiation
A6F57_00690	COG2226	methyltransferase
A6F57_00690	COG0596	Alpha beta hydrolase
A6F57_00690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F57_00715	COG0583	DNA-binding transcription factor activity
A6F57_00735	COG5001	Diguanylate cyclase
A6F57_00735	COG3300	MHYT domain
A6F57_00750	COG5001	Diguanylate cyclase
A6F57_00750	COG2203	Gaf domain
A6F57_00750	COG3706	GGDEF domain
A6F57_00750	COG4251	negative regulation of phosphorylation
A6F57_00765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6F57_00770	COG4136	ATPase activity
A6F57_00780	COG4135	transport system, permease component
A6F57_00800	COG4771	TonB-dependent receptor
A6F57_00815	COG1032	radical SAM domain protein
A6F57_00840	COG4774	siderophore transport
A6F57_00850	COG0450	alkyl hydroperoxide reductase
A6F57_00875	COG3153	acetyltransferase
A6F57_00875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F57_00885	COG0596	Alpha beta hydrolase
A6F57_00890	COG3706	GGDEF domain
A6F57_00900	COG4269	membrane
A6F57_00910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6F57_00925	COG0195	Participates in both transcription termination and antitermination
A6F57_00935	COG3437	response regulator, receiver
A6F57_00940	COG2198	Histidine kinase
A6F57_00940	COG0784	Response regulator, receiver
A6F57_00940	COG2205	protein histidine kinase activity
A6F57_00960	COG4771	TonB-dependent receptor
A6F57_00965	COG0668	transmembrane transport
A6F57_00985	COG0668	transmembrane transport
A6F57_01005	COG0246	Mannitol dehydrogenase
A6F57_01015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_01020	COG2390	Transcriptional regulator
A6F57_01035	COG0596	Alpha beta hydrolase
A6F57_01040	COG1960	acyl-CoA dehydrogenase activity
A6F57_01045	COG0183	Belongs to the thiolase family
A6F57_01050	COG1024	Enoyl-CoA hydratase
A6F57_01050	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F57_01055	COG0596	Alpha beta hydrolase
A6F57_01085	COG1960	acyl-CoA dehydrogenase activity
A6F57_01095	COG4771	TonB-dependent receptor
A6F57_01115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F57_01135	COG0314	molybdopterin synthase activity
A6F57_01140	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6F57_01145	COG0315	cyclic pyranopterin monophosphate synthase activity
A6F57_01150	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6F57_01155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F57_01215	COG2801	Transposase and inactivated derivatives
A6F57_01265	COG3547	Transposase (IS116 IS110 IS902 family)
A6F57_01330	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_01365	COG0436	Aminotransferase
A6F57_01370	COG3268	Saccharopine dehydrogenase
A6F57_01385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F57_01400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6F57_01405	COG1074	ATP-dependent DNA helicase activity
A6F57_01410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6F57_01420	COG1022	Amp-dependent synthetase and ligase
A6F57_01425	COG5001	Diguanylate cyclase
A6F57_01425	COG3300	MHYT domain
A6F57_01450	COG0583	DNA-binding transcription factor activity
A6F57_01470	COG0640	Transcriptional regulator
A6F57_01480	COG0583	DNA-binding transcription factor activity
A6F57_01490	COG2204	response regulator
A6F57_01505	COG0784	Response regulator, receiver
A6F57_01535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6F57_01560	COG3139	Protein of unknown function (DUF1315)
A6F57_01570	COG1115	amino acid carrier protein
A6F57_01575	COG2866	Carboxypeptidase
A6F57_01595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6F57_01605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6F57_01610	COG1640	4-alpha-glucanotransferase
A6F57_01620	COG0676	glucose-6-phosphate 1-epimerase activity
A6F57_01625	COG0800	Aldolase
A6F57_01635	COG0129	dihydroxy-acid dehydratase activity
A6F57_01645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6F57_01650	COG1737	Transcriptional regulator
A6F57_01655	COG0469	pyruvate kinase activity
A6F57_01660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F57_01705	COG2205	protein histidine kinase activity
A6F57_01710	COG0745	RESPONSE REGULATOR receiver
A6F57_01735	COG3665	Urea carboxylase-associated protein
A6F57_01745	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_01750	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6F57_01775	COG2721	sulfolactate sulfo-lyase activity
A6F57_01780	COG1904	glucuronate isomerase
A6F57_01785	COG0246	Mannitol dehydrogenase
A6F57_01790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_01795	COG2755	lipolytic protein G-D-S-L family
A6F57_01805	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6F57_01815	COG4677	pectinesterase activity
A6F57_01820	COG4999	Histidine kinase
A6F57_01820	COG3437	response regulator, receiver
A6F57_01820	COG2205	protein histidine kinase activity
A6F57_01820	COG3850	Histidine kinase
A6F57_01835	COG2356	endonuclease I
A6F57_01845	COG1024	Enoyl-CoA hydratase
A6F57_01855	COG2801	Transposase and inactivated derivatives
A6F57_01870	COG1609	Transcriptional regulator
A6F57_01880	COG0673	inositol 2-dehydrogenase activity
A6F57_01910	COG0746	molybdenum cofactor guanylyltransferase activity
A6F57_01920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F57_01925	COG1764	response to oxidative stress
A6F57_01940	COG3706	GGDEF domain
A6F57_01950	COG0745	RESPONSE REGULATOR receiver
A6F57_01955	COG5002	protein histidine kinase activity
A6F57_01955	COG3850	Histidine kinase
A6F57_01985	COG1957	nucleoside hydrolase
A6F57_01990	COG0738	Major facilitator superfamily
A6F57_02015	COG0840	transmembrane signaling receptor activity
A6F57_02025	COG0753	catalase activity
A6F57_02035	COG0330	HflC and HflK could
A6F57_02055	COG0778	Nitroreductase
A6F57_02075	COG0471	metal ion transport
A6F57_02085	COG0489	protein tyrosine kinase activity
A6F57_02090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_02090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_02095	COG2226	methyltransferase
A6F57_02100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F57_02105	COG1388	LysM domain
A6F57_02105	COG0741	lytic transglycosylase activity
A6F57_02125	COG2942	2-epimerase
A6F57_02130	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6F57_02140	COG1609	Transcriptional regulator
A6F57_02145	COG2942	2-epimerase
A6F57_02150	COG3119	arylsulfatase activity
A6F57_02165	COG4124	Belongs to the glycosyl hydrolase 26 family
A6F57_02195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F57_02205	COG1785	Belongs to the alkaline phosphatase family
A6F57_02210	COG1785	Belongs to the alkaline phosphatase family
A6F57_02225	COG2268	Band 7 protein
A6F57_02245	COG0542	response to heat
A6F57_02250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F57_02255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6F57_02260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6F57_02265	COG2080	2 iron, 2 sulfur cluster binding
A6F57_02275	COG0604	alcohol dehydrogenase
A6F57_02285	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6F57_02300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6F57_02305	COG1286	toxin biosynthetic process
A6F57_02310	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6F57_02315	COG0285	dihydrofolate synthase activity
A6F57_02325	COG0101	tRNA pseudouridine synthase activity
A6F57_02340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F57_02365	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6F57_02365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6F57_02395	COG3101	peptidyl-lysine hydroxylation
A6F57_02440	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F57_02440	COG1902	pentaerythritol trinitrate reductase activity
A6F57_02465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6F57_02470	COG1309	transcriptional regulator
A6F57_02475	COG4399	Belongs to the UPF0754 family
A6F57_02510	COG2186	Transcriptional regulator
A6F57_02520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6F57_02525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6F57_02530	COG2983	Belongs to the UPF0260 family
A6F57_02535	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6F57_02550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6F57_02555	COG0318	PFAM AMP-dependent synthetase and ligase
A6F57_02560	COG2267	carboxylic ester hydrolase activity
A6F57_02575	COG1214	PFAM Peptidase M22, glycoprotease
A6F57_02580	COG1199	ATP-dependent helicase activity
A6F57_02635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6F57_02640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6F57_02645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F57_02650	COG0131	Imidazoleglycerol-phosphate dehydratase
A6F57_02650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6F57_02655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6F57_02670	COG0140	phosphoribosyl-ATP diphosphatase activity
A6F57_02670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6F57_02690	COG0300	oxidoreductase activity
A6F57_02710	COG0583	DNA-binding transcription factor activity
A6F57_02725	COG0681	Belongs to the peptidase S26 family
A6F57_02745	COG0326	Molecular chaperone. Has ATPase activity
A6F57_02750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6F57_02775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6F57_02780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F57_02790	COG3220	belongs to the UPF0276 family
A6F57_02800	COG4249	Peptidase C14 caspase catalytic subunit p20
A6F57_02800	COG2319	Wd-40 repeat
A6F57_02855	COG1183	phosphatidylcholine synthase activity
A6F57_02875	COG0542	response to heat
A6F57_02885	COG0564	pseudouridine synthase activity
A6F57_02900	COG1595	DNA-templated transcription, initiation
A6F57_02915	COG4221	oxidoreductase activity
A6F57_02930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6F57_02940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6F57_02945	COG1722	exodeoxyribonuclease VII activity
A6F57_02950	COG0142	geranyltranstransferase activity
A6F57_02960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6F57_02965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6F57_02975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6F57_02990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F57_02990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F57_03005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6F57_03010	COG0488	(ABC) transporter
A6F57_03020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6F57_03030	COG0560	Phosphoserine phosphatase
A6F57_03040	COG0084	hydrolase, TatD family'
A6F57_03060	COG0681	Belongs to the peptidase S26 family
A6F57_03085	COG1595	DNA-templated transcription, initiation
A6F57_03090	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6F57_03105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6F57_03125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F57_03185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6F57_03190	COG1047	Peptidyl-prolyl cis-trans
A6F57_03200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6F57_03205	COG0196	riboflavin kinase activity
A6F57_03210	COG0728	peptidoglycan biosynthetic process
A6F57_03215	COG0268	Binds directly to 16S ribosomal RNA
A6F57_03230	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_03235	COG0385	Bile acid
A6F57_03260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F57_03265	COG0776	regulation of translation
A6F57_03270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6F57_03275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6F57_03280	COG0740	serine-type endopeptidase activity
A6F57_03285	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6F57_03325	COG1720	tRNA m6t6A37 methyltransferase activity
A6F57_03340	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A6F57_03345	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6F57_03365	COG0517	IMP dehydrogenase activity
A6F57_03365	COG0516	GMP reductase activity
A6F57_03370	COG1570	exodeoxyribonuclease VII activity
A6F57_03385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F57_03390	COG2976	Protein conserved in bacteria
A6F57_03415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6F57_03425	COG2166	iron-sulfur cluster assembly
A6F57_03440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6F57_03445	COG0719	Fe-S assembly protein
A6F57_03450	COG0396	ATPase activity
A6F57_03455	COG0719	Fe-S assembly protein
A6F57_03460	COG1104	cysteine desulfurase activity
A6F57_03475	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6F57_03480	COG0483	inositol monophosphate 1-phosphatase activity
A6F57_03510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F57_03515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F57_03520	COG1862	Preprotein translocase
A6F57_03525	COG0343	queuine tRNA-ribosyltransferase activity
A6F57_03540	COG3789	protein conserved in bacteria
A6F57_03545	COG1842	Phage shock protein A
A6F57_03570	COG0754	glutathionylspermidine amidase activity
A6F57_03585	COG2066	Belongs to the glutaminase family
A6F57_03590	COG1785	Belongs to the alkaline phosphatase family
A6F57_03645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6F57_03650	COG1045	serine acetyltransferase
A6F57_03675	COG0438	transferase activity, transferring glycosyl groups
A6F57_03720	COG0463	Glycosyl transferase, family 2
A6F57_03720	COG1216	Glycosyl transferase, family 2
A6F57_03755	COG0489	protein tyrosine kinase activity
A6F57_03770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6F57_03770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6F57_03775	COG2827	Endonuclease containing a URI domain
A6F57_03795	COG1560	Kdo2-lipid A biosynthetic process
A6F57_03840	COG1435	thymidine kinase activity
A6F57_03850	COG1609	Transcriptional regulator
A6F57_03855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6F57_03895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6F57_03900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F57_03905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6F57_03910	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6F57_03935	COG0515	serine threonine protein kinase
A6F57_03965	COG4774	siderophore transport
A6F57_03980	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_03995	COG4774	siderophore transport
A6F57_03995	COG1629	transport
A6F57_04000	COG4682	membrane
A6F57_04015	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6F57_04020	COG0789	Transcriptional regulator
A6F57_04035	COG0189	ligase activity
A6F57_04050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6F57_04090	COG1960	acyl-CoA dehydrogenase activity
A6F57_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F57_04130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F57_04180	COG1607	acyl-coa hydrolase
A6F57_04185	COG0826	peptidase U32
A6F57_04250	COG0583	DNA-binding transcription factor activity
A6F57_04265	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_04270	COG1733	regulation of RNA biosynthetic process
A6F57_04285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F57_04325	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_04335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6F57_04340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F57_04345	COG1845	cytochrome c oxidase, subunit III
A6F57_04355	COG0109	protoheme IX farnesyltransferase activity
A6F57_04370	COG0583	DNA-binding transcription factor activity
A6F57_04385	COG4221	oxidoreductase activity
A6F57_04390	COG0693	protein deglycase activity
A6F57_04445	COG1230	cation diffusion facilitator family transporter
A6F57_04450	COG0789	Transcriptional regulator
A6F57_04480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F57_04485	COG1335	isochorismatase
A6F57_04490	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A6F57_04510	COG4771	TonB-dependent receptor
A6F57_04545	COG1566	PFAM secretion protein HlyD family protein
A6F57_04550	COG1846	Transcriptional regulator
A6F57_04560	COG1295	ribonuclease BN
A6F57_04570	COG4681	YaeQ
A6F57_04590	COG0583	DNA-binding transcription factor activity
A6F57_04600	COG0484	heat shock protein binding
A6F57_04625	COG2319	Wd-40 repeat
A6F57_04625	COG4249	Peptidase C14 caspase catalytic subunit p20
A6F57_04640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6F57_04660	COG1451	nucleotide metabolic process
A6F57_04675	COG0653	protein targeting
A6F57_04710	COG2133	pyrroloquinoline quinone binding
A6F57_04720	COG0697	spore germination
A6F57_04725	COG3813	Protein conserved in bacteria
A6F57_04730	COG0513	Belongs to the DEAD box helicase family
A6F57_04780	COG2814	Major facilitator Superfamily
A6F57_04790	COG0656	L-ascorbic acid biosynthetic process
A6F57_04815	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F57_04870	COG1484	DNA-dependent DNA replication
A6F57_04900	COG3209	COG3209 Rhs family protein
A6F57_04925	COG4974	Belongs to the 'phage' integrase family
A6F57_04945	COG0583	DNA-binding transcription factor activity
A6F57_04960	COG1621	beta-fructofuranosidase activity
A6F57_04965	COG0477	Major facilitator Superfamily
A6F57_04975	COG4206	TonB-dependent receptor
A6F57_04975	COG1629	transport
A6F57_05000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F57_05005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F57_05010	COG0006	proline dipeptidase activity
A6F57_05025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_05030	COG1957	nucleoside hydrolase
A6F57_05040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6F57_05045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6F57_05050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F57_05070	COG3313	Fe-S protein
A6F57_05110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F57_05115	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F57_05120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6F57_05125	COG2186	Transcriptional regulator
A6F57_05150	COG4969	Belongs to the N-Me-Phe pilin family
A6F57_05155	COG1459	type II secretion system
A6F57_05165	COG0237	dephospho-CoA kinase activity
A6F57_05165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6F57_05170	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6F57_05180	COG2988	succinylglutamate desuccinylase activity
A6F57_05185	COG0494	nUDIX hydrolase
A6F57_05195	COG0739	heme binding
A6F57_05200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6F57_05210	COG0849	cell division
A6F57_05215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6F57_05220	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F57_05225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F57_05235	COG0772	Belongs to the SEDS family
A6F57_05240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6F57_05250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6F57_05255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6F57_05260	COG0768	penicillin binding
A6F57_05265	COG3116	cell division
A6F57_05275	COG2001	Belongs to the MraZ family
A6F57_05315	COG0678	peroxiredoxin activity
A6F57_05315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F57_05320	COG5001	Diguanylate cyclase
A6F57_05320	COG3706	GGDEF domain
A6F57_05320	COG4251	negative regulation of phosphorylation
A6F57_05320	COG2203	Gaf domain
A6F57_05330	COG2204	response regulator
A6F57_05335	COG2198	Histidine kinase
A6F57_05335	COG5002	protein histidine kinase activity
A6F57_05335	COG0784	Response regulator, receiver
A6F57_05355	COG0668	transmembrane transport
A6F57_05360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6F57_05365	COG0189	ligase activity
A6F57_05370	COG1678	Uncharacterized ACR, COG1678
A6F57_05375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6F57_05395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6F57_05400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F57_05405	COG0762	integral membrane protein
A6F57_05420	COG1902	pentaerythritol trinitrate reductase activity
A6F57_05420	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F57_05435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_05440	COG0625	glutathione transferase activity
A6F57_05480	COG0583	DNA-binding transcription factor activity
A6F57_05490	COG2197	response regulator
A6F57_05495	COG4585	Histidine kinase
A6F57_05515	COG0640	Transcriptional regulator
A6F57_05525	COG0431	NADPH-dependent FMN reductase
A6F57_05530	COG0798	PFAM Bile acid sodium symporter
A6F57_05535	COG2201	protein-glutamate methylesterase activity
A6F57_05540	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A6F57_05545	COG0745	RESPONSE REGULATOR receiver
A6F57_05550	COG5002	protein histidine kinase activity
A6F57_05580	COG1748	Saccharopine dehydrogenase
A6F57_05595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6F57_05600	COG3107	peptidoglycan biosynthetic process
A6F57_05605	COG0792	nuclease activity
A6F57_05615	COG2823	Periplasmic or secreted lipoprotein
A6F57_05645	COG4585	Histidine kinase
A6F57_05650	COG2197	response regulator
A6F57_05655	COG4771	TonB-dependent receptor
A6F57_05665	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6F57_05670	COG0372	Belongs to the citrate synthase family
A6F57_05685	COG2199	diguanylate cyclase activity
A6F57_05685	COG2203	Gaf domain
A6F57_05730	COG5002	protein histidine kinase activity
A6F57_05730	COG2198	Histidine kinase
A6F57_05730	COG0784	Response regulator, receiver
A6F57_05735	COG0070	glutamate synthase
A6F57_05735	COG0069	glutamate synthase activity
A6F57_05735	COG0067	glutamate synthase
A6F57_05740	COG0493	'glutamate synthase
A6F57_05750	COG1476	TRANSCRIPTIONal
A6F57_05755	COG3866	Pectate lyase
A6F57_05775	COG3866	Pectate lyase
A6F57_05790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F57_05805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F57_05825	COG0739	heme binding
A6F57_05830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6F57_05840	COG0738	Major facilitator superfamily
A6F57_05850	COG1902	pentaerythritol trinitrate reductase activity
A6F57_05860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F57_05865	COG0625	glutathione transferase activity
A6F57_05885	COG2894	cell division
A6F57_05890	COG0850	regulation of cytokinetic process
A6F57_05930	COG1914	H( )-stimulated, divalent metal cation uptake system
A6F57_05935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6F57_05955	COG0174	glutamine synthetase
A6F57_05965	COG3852	Histidine kinase
A6F57_05975	COG3437	response regulator, receiver
A6F57_05980	COG0204	Acyl-transferase
A6F57_05995	COG3706	GGDEF domain
A6F57_06010	COG0525	valine-tRNA ligase activity
A6F57_06015	COG2927	DNA polymerase III (CHI subunit)
A6F57_06020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F57_06025	COG0795	lipopolysaccharide-transporting ATPase activity
A6F57_06030	COG0795	lipopolysaccharide-transporting ATPase activity
A6F57_06080	COG4264	IucA IucC family
A6F57_06085	COG0318	PFAM AMP-dependent synthetase and ligase
A6F57_06095	COG1082	Xylose isomerase domain protein TIM barrel
A6F57_06135	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6F57_06150	COG0251	oxidation-reduction process
A6F57_06195	COG4191	Histidine kinase
A6F57_06205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_06235	COG3706	GGDEF domain
A6F57_06240	COG3706	GGDEF domain
A6F57_06280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F57_06285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6F57_06290	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A6F57_06300	COG0535	radical SAM domain protein
A6F57_06330	COG2205	protein histidine kinase activity
A6F57_06330	COG0784	Response regulator, receiver
A6F57_06340	COG0348	domain, Protein
A6F57_06340	COG3901	Regulator of nitric oxide reductase transcription
A6F57_06345	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_06350	COG2197	response regulator
A6F57_06355	COG4585	Histidine kinase
A6F57_06385	COG4771	TonB-dependent receptor
A6F57_06390	COG1858	cytochrome C peroxidase
A6F57_06420	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_06430	COG1917	Cupin 2, conserved barrel domain protein
A6F57_06435	COG2271	Major facilitator Superfamily
A6F57_06455	COG1716	ATPase activity
A6F57_06490	COG0515	serine threonine protein kinase
A6F57_06490	COG1357	PFAM Pentapeptide repeats (8 copies)
A6F57_06510	COG0842	Transport permease protein
A6F57_06510	COG1131	(ABC) transporter
A6F57_06510	COG1716	ATPase activity
A6F57_06520	COG0513	Belongs to the DEAD box helicase family
A6F57_06525	COG0800	Aldolase
A6F57_06530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_06535	COG2186	Transcriptional regulator
A6F57_06545	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6F57_06545	COG3264	Mechanosensitive ion channel
A6F57_06580	COG3568	Endonuclease Exonuclease Phosphatase
A6F57_06595	COG0730	response to heat
A6F57_06615	COG4191	Histidine kinase
A6F57_06625	COG0417	DNA replication proofreading
A6F57_06680	COG1309	transcriptional regulator
A6F57_06695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F57_06705	COG1573	uracil-dna glycosylase
A6F57_06710	COG5001	Diguanylate cyclase
A6F57_06710	COG3300	MHYT domain
A6F57_06730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6F57_06735	COG4771	TonB-dependent receptor
A6F57_06760	COG1842	Phage shock protein A
A6F57_06770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F57_06795	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6F57_06800	COG0204	Acyl-transferase
A6F57_06805	COG0204	Acyl-transferase
A6F57_06810	COG0668	transmembrane transport
A6F57_06825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F57_06830	COG0733	neurotransmitter:sodium symporter activity
A6F57_06845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F57_06860	COG0716	FMN binding
A6F57_06870	COG0848	biopolymer transport protein
A6F57_06880	COG0457	Tetratricopeptide repeat
A6F57_06910	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6F57_06915	COG0702	epimerase
A6F57_06930	COG5002	protein histidine kinase activity
A6F57_06930	COG5001	Diguanylate cyclase
A6F57_06940	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6F57_06945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F57_06955	COG0583	DNA-binding transcription factor activity
A6F57_06960	COG0121	glutamine amidotransferase
A6F57_06975	COG1522	sequence-specific DNA binding
A6F57_06980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F57_06990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6F57_07000	COG1477	protein flavinylation
A6F57_07005	COG2871	sodium ion transport
A6F57_07010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6F57_07015	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6F57_07020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6F57_07025	COG1805	sodium ion transport
A6F57_07035	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F57_07040	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F57_07045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6F57_07065	COG0039	L-malate dehydrogenase activity
A6F57_07070	COG1438	arginine binding
A6F57_07100	COG0572	uridine kinase
A6F57_07105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6F57_07120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F57_07130	COG0745	RESPONSE REGULATOR receiver
A6F57_07130	COG3706	GGDEF domain
A6F57_07145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_07165	COG0189	ligase activity
A6F57_07175	COG4067	protein conserved in archaea
A6F57_07175	COG0189	ligase activity
A6F57_07190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6F57_07205	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6F57_07210	COG0667	Aldo Keto reductase
A6F57_07225	COG0753	catalase activity
A6F57_07260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6F57_07265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6F57_07265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6F57_07270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6F57_07330	COG0583	DNA-binding transcription factor activity
A6F57_07340	COG1216	Glycosyl transferase, family 2
A6F57_07340	COG0438	transferase activity, transferring glycosyl groups
A6F57_07410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F57_07415	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6F57_07425	COG1083	cytidylyl-transferase
A6F57_07465	COG1216	Glycosyl transferase, family 2
A6F57_07465	COG0463	Glycosyl transferase, family 2
A6F57_07490	COG0662	Cupin 2, conserved barrel domain protein
A6F57_07490	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6F57_07500	COG0202	RNA polymerase activity
A6F57_07520	COG0201	protein transport
A6F57_07540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6F57_07575	COG5002	protein histidine kinase activity
A6F57_07575	COG0784	Response regulator, receiver
A6F57_07595	COG0557	exoribonuclease II activity
A6F57_07610	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6F57_07625	COG0543	2 iron, 2 sulfur cluster binding
A6F57_07630	COG2234	aminopeptidase activity
A6F57_07650	COG1271	oxidase subunit
A6F57_07655	COG1294	oxidase, subunit
A6F57_07660	COG0840	transmembrane signaling receptor activity
A6F57_07665	COG1522	sequence-specific DNA binding
A6F57_07680	COG1278	Cold shock
A6F57_07685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F57_07705	COG0339	signal peptide processing
A6F57_07710	COG2201	protein-glutamate methylesterase activity
A6F57_07730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F57_07735	COG0243	molybdopterin cofactor binding
A6F57_07740	COG4946	Tricorn protease homolog
A6F57_07740	COG0793	Belongs to the peptidase S41A family
A6F57_07780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6F57_07785	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F57_07790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6F57_07805	COG0281	malic enzyme
A6F57_07810	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6F57_07815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6F57_07845	COG0456	acetyltransferase
A6F57_07855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6F57_07860	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6F57_07865	COG2177	Part of the ABC transporter FtsEX involved in
A6F57_07870	COG2884	Cell division ATP-binding protein ftsE
A6F57_07875	COG0552	protein localization to endoplasmic reticulum
A6F57_07890	COG2095	MarC family integral membrane protein
A6F57_07910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F57_07915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F57_07925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6F57_07940	COG0076	glutamate decarboxylase activity
A6F57_07945	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6F57_07955	COG0842	Transport permease protein
A6F57_07960	COG1131	(ABC) transporter
A6F57_07965	COG0745	RESPONSE REGULATOR receiver
A6F57_07970	COG2205	protein histidine kinase activity
A6F57_07975	COG4774	siderophore transport
A6F57_07995	COG1253	flavin adenine dinucleotide binding
A6F57_08000	COG0701	Predicted permease
A6F57_08005	COG1966	Carbon starvation protein
A6F57_08060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F57_08065	COG0049	tRNA binding
A6F57_08070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6F57_08075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6F57_08080	COG0085	RNA polymerase activity
A6F57_08085	COG0222	ribosome binding
A6F57_08090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6F57_08095	COG0081	regulation of translation
A6F57_08100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6F57_08105	COG0250	Participates in transcription elongation, termination and antitermination
A6F57_08110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6F57_08120	COG1132	(ABC) transporter
A6F57_08125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6F57_08130	COG3590	peptidase
A6F57_08140	COG0513	Belongs to the DEAD box helicase family
A6F57_08145	COG0418	dihydroorotase activity
A6F57_08155	COG3040	lipid binding
A6F57_08160	COG4989	oxidoreductase activity
A6F57_08165	COG0346	lactoylglutathione lyase activity
A6F57_08180	COG0302	gtp cyclohydrolase
A6F57_08200	COG2957	Belongs to the agmatine deiminase family
A6F57_08205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F57_08220	COG3306	glycosyltransferase involved in LPS biosynthesis
A6F57_08225	COG1201	RNA secondary structure unwinding
A6F57_08235	COG1793	dna ligase
A6F57_08245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_08260	COG0625	glutathione transferase activity
A6F57_08275	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6F57_08280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F57_08290	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_08305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6F57_08310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F57_08315	COG0330	HflC and HflK could
A6F57_08320	COG0330	HflC and HflK could
A6F57_08325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6F57_08330	COG1923	regulation of RNA biosynthetic process
A6F57_08335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6F57_08350	COG0802	atpase or kinase
A6F57_08355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6F57_08355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6F57_08360	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6F57_08370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6F57_08375	COG2816	NAD+ diphosphatase activity
A6F57_08380	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6F57_08385	COG0735	belongs to the Fur family
A6F57_08395	COG0432	Pfam Uncharacterised protein family UPF0047
A6F57_08430	COG2258	MOSC domain
A6F57_08460	COG5002	protein histidine kinase activity
A6F57_08470	COG0840	transmembrane signaling receptor activity
A6F57_08475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_08475	COG4191	Histidine kinase
A6F57_08485	COG1609	Transcriptional regulator
A6F57_08490	COG2211	Major facilitator Superfamily
A6F57_08495	COG2723	6-phospho-beta-galactosidase activity
A6F57_08505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6F57_08510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6F57_08515	COG4558	Periplasmic binding protein
A6F57_08525	COG4206	TonB-dependent receptor
A6F57_08535	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F57_08550	COG2855	membrane
A6F57_08555	COG2175	clavaminate synthase activity
A6F57_08560	COG0656	L-ascorbic acid biosynthetic process
A6F57_08580	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_08585	COG1230	cation diffusion facilitator family transporter
A6F57_08620	COG4771	TonB-dependent receptor
A6F57_08625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6F57_08630	COG4988	ABC transporter
A6F57_08640	COG1294	oxidase, subunit
A6F57_08655	COG2204	response regulator
A6F57_08690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F57_08715	COG4319	ketosteroid isomerase
A6F57_08755	COG3237	CsbD-like
A6F57_08800	COG2267	carboxylic ester hydrolase activity
A6F57_08825	COG3038	cytochrome b561
A6F57_08830	COG2353	YceI-like domain
A6F57_08835	COG1252	NADH dehydrogenase
A6F57_08860	COG2067	long-chain fatty acid transport protein
A6F57_08865	COG2130	NADP-dependent
A6F57_08870	COG5001	Diguanylate cyclase
A6F57_08870	COG3706	GGDEF domain
A6F57_08870	COG4251	negative regulation of phosphorylation
A6F57_08870	COG2203	Gaf domain
A6F57_08890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F57_08900	COG4181	ATPase activity
A6F57_08920	COG0523	cobalamin synthesis protein
A6F57_08935	COG4771	TonB-dependent receptor
A6F57_08940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F57_09000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6F57_09005	COG1349	DNA-binding transcription factor activity
A6F57_09020	COG0697	spore germination
A6F57_09025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6F57_09030	COG4977	sequence-specific DNA binding
A6F57_09040	COG1166	arginine decarboxylase activity
A6F57_09050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6F57_09055	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6F57_09060	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6F57_09070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F57_09080	COG0523	cobalamin synthesis protein
A6F57_09110	COG4232	protein-disulfide reductase activity
A6F57_09115	COG0739	heme binding
A6F57_09120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6F57_09125	COG0511	ligase activity, forming carbon-carbon bonds
A6F57_09130	COG0439	Biotin carboxylase
A6F57_09150	COG2176	DNA-directed DNA polymerase activity
A6F57_09170	COG0154	amidase activity
A6F57_09185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F57_09190	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6F57_09205	COG0151	Belongs to the GarS family
A6F57_09215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F57_09225	COG3954	Phosphoribulokinase
A6F57_09230	COG2233	PERMEase
A6F57_09245	COG0745	RESPONSE REGULATOR receiver
A6F57_09265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6F57_09275	COG3031	protein transport across the cell outer membrane
A6F57_09285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6F57_09290	COG1459	type II secretion system
A6F57_09295	COG2165	general secretion pathway protein
A6F57_09305	COG2165	general secretion pathway protein
A6F57_09310	COG4795	General secretion pathway protein
A6F57_09325	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6F57_09335	COG1234	tRNA 3'-trailer cleavage
A6F57_09340	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_09350	COG1011	Hydrolase
A6F57_09355	COG0494	nUDIX hydrolase
A6F57_09360	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6F57_09375	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6F57_09385	COG3089	Belongs to the UPF0270 family
A6F57_09390	COG0429	hydrolase of the alpha beta-hydrolase fold
A6F57_09400	COG0488	(ABC) transporter
A6F57_09425	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F57_09435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F57_09440	COG2183	response to ionizing radiation
A6F57_09455	COG0596	Alpha beta hydrolase
A6F57_09460	COG1040	competence protein
A6F57_09480	COG1794	racemase activity, acting on amino acids and derivatives
A6F57_09495	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A6F57_09500	COG0534	Mate efflux family protein
A6F57_09515	COG1999	signal sequence binding
A6F57_09520	COG0109	protoheme IX farnesyltransferase activity
A6F57_09525	COG1612	heme a metabolic process
A6F57_09550	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6F57_09555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F57_09560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6F57_09560	COG1565	acr, cog1565
A6F57_09590	COG0129	dihydroxy-acid dehydratase activity
A6F57_09595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6F57_09610	COG0583	DNA-binding transcription factor activity
A6F57_09620	COG2814	Major facilitator Superfamily
A6F57_09630	COG0729	surface antigen
A6F57_09635	COG2911	Protein conserved in bacteria
A6F57_09660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F57_09670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6F57_09690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F57_09740	COG0425	Belongs to the sulfur carrier protein TusA family
A6F57_09755	COG1561	YicC-like family, N-terminal region
A6F57_09790	COG2211	Major facilitator Superfamily
A6F57_09795	COG1609	Transcriptional regulator
A6F57_09810	COG2199	diguanylate cyclase activity
A6F57_09810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6F57_09840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6F57_09860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F57_09865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F57_09885	COG1475	DNA binding
A6F57_09890	COG1192	Involved in chromosome partitioning
A6F57_09915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6F57_09920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6F57_09930	COG0706	membrane insertase activity
A6F57_09935	COG0594	ribonuclease P activity
A6F57_09940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6F57_09955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6F57_09960	COG0187	DNA topoisomerase II activity
A6F57_09985	COG2818	Glycosylase
A6F57_09995	COG3078	GTPase activator activity
A6F57_10010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F57_10010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F57_10015	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6F57_10020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6F57_10025	COG0569	domain protein
A6F57_10030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F57_10030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F57_10050	COG0758	DNA mediated transformation
A6F57_10065	COG0009	L-threonylcarbamoyladenylate synthase
A6F57_10070	COG0408	coproporphyrinogen oxidase activity
A6F57_10075	COG3047	cAMP biosynthetic process
A6F57_10090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6F57_10175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6F57_10195	COG2234	aminopeptidase activity
A6F57_10210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6F57_10235	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F57_10275	COG3642	lipopolysaccharide core region biosynthetic process
A6F57_10280	COG0859	PFAM glycosyl transferase family 9
A6F57_10300	COG0156	8-amino-7-oxononanoate synthase activity
A6F57_10310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F57_10315	COG0705	Rhomboid family
A6F57_10325	COG3161	chorismate lyase activity
A6F57_10330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6F57_10335	COG2960	long-chain fatty acid transporting porin activity
A6F57_10340	COG0210	DNA helicase
A6F57_10400	COG0582	viral genome integration into host DNA
A6F57_10455	COG1715	Restriction endonuclease
A6F57_10460	COG1674	ftsk spoiiie
A6F57_10475	COG1620	l-lactate permease
A6F57_10495	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F57_10495	COG1902	pentaerythritol trinitrate reductase activity
A6F57_10515	COG4638	Rieske (2fe-2S)
A6F57_10525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6F57_10525	COG1017	nitric oxide dioxygenase activity
A6F57_10530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6F57_10570	COG1760	l-serine dehydratase
A6F57_10575	COG0583	DNA-binding transcription factor activity
A6F57_10590	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_10595	COG4948	Mandelate Racemase Muconate Lactonizing
A6F57_10605	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_10610	COG4771	TonB-dependent receptor
A6F57_10615	COG0457	Tetratricopeptide repeat
A6F57_10620	COG3437	response regulator, receiver
A6F57_10620	COG2205	protein histidine kinase activity
A6F57_10620	COG3850	Histidine kinase
A6F57_10620	COG4999	Histidine kinase
A6F57_10625	COG4773	Receptor
A6F57_10630	COG0583	DNA-binding transcription factor activity
A6F57_10645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_10650	COG1129	ABC transporter
A6F57_10650	COG0842	Transport permease protein
A6F57_10655	COG0842	Transport permease protein
A6F57_10665	COG1960	acyl-CoA dehydrogenase activity
A6F57_10670	COG0583	DNA-binding transcription factor activity
A6F57_10685	COG3106	COG3106 Predicted ATPase
A6F57_10705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6F57_10720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F57_10735	COG4771	TonB-dependent receptor
A6F57_10740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F57_10750	COG0778	Nitroreductase
A6F57_10750	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A6F57_10765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6F57_10770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6F57_10775	COG1309	transcriptional regulator
A6F57_10810	COG3071	HemY protein
A6F57_10815	COG2959	enzyme of heme biosynthesis
A6F57_10825	COG0181	hydroxymethylbilane synthase activity
A6F57_10830	COG0745	RESPONSE REGULATOR receiver
A6F57_10830	COG3706	GGDEF domain
A6F57_10840	COG0194	GDP metabolic process
A6F57_10850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6F57_10860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F57_10865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6F57_10875	COG0678	peroxiredoxin activity
A6F57_10875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F57_10895	COG1178	ABC-type Fe3 transport system permease component
A6F57_10900	COG3842	ATPase activity
A6F57_10905	COG5001	Diguanylate cyclase
A6F57_10905	COG3300	MHYT domain
A6F57_10915	COG2081	HI0933 family
A6F57_10920	COG0668	transmembrane transport
A6F57_10945	COG5002	protein histidine kinase activity
A6F57_10945	COG3447	MASE1 domain protein
A6F57_10945	COG5001	Diguanylate cyclase
A6F57_10955	COG0583	DNA-binding transcription factor activity
A6F57_10965	COG2076	Multidrug Resistance protein
A6F57_10980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_10985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_10995	COG0427	acetyl-CoA hydrolase
A6F57_11000	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6F57_11010	COG0840	transmembrane signaling receptor activity
A6F57_11020	COG3064	Membrane
A6F57_11025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6F57_11030	COG5001	Diguanylate cyclase
A6F57_11030	COG5002	protein histidine kinase activity
A6F57_11040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6F57_11050	COG0514	ATP-dependent DNA helicase (RecQ)
A6F57_11055	COG2050	protein possibly involved in aromatic compounds catabolism
A6F57_11060	COG2239	Acts as a magnesium transporter
A6F57_11070	COG3706	GGDEF domain
A6F57_11070	COG0745	RESPONSE REGULATOR receiver
A6F57_11085	COG1011	Hydrolase
A6F57_11100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6F57_11105	COG0019	diaminopimelate decarboxylase activity
A6F57_11135	COG0163	prenyltransferase activity
A6F57_11140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F57_11150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6F57_11175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F57_11180	COG2814	Major facilitator Superfamily
A6F57_11185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_11205	COG1085	galactose-1-phosphate uridylyltransferase
A6F57_11210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6F57_11220	COG0629	single-stranded DNA binding
A6F57_11235	COG0745	RESPONSE REGULATOR receiver
A6F57_11245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6F57_11275	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_11300	COG1349	DNA-binding transcription factor activity
A6F57_11340	COG3409	Peptidoglycan-binding domain 1 protein
A6F57_11340	COG3267	Type II secretory pathway component ExeA
A6F57_11350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6F57_11355	COG1459	type II secretion system
A6F57_11395	COG1077	Cell shape determining protein MreB Mrl
A6F57_11400	COG1792	Involved in formation and maintenance of cell shape
A6F57_11405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6F57_11415	COG1530	ribonuclease E activity
A6F57_11425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F57_11430	COG0312	modulator of DNA gyrase
A6F57_11440	COG3028	Belongs to the UPF0307 family
A6F57_11445	COG0312	modulator of DNA gyrase
A6F57_11460	COG0745	RESPONSE REGULATOR receiver
A6F57_11465	COG4191	Histidine kinase
A6F57_11465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_11470	COG0297	glycogen (starch) synthase activity
A6F57_11480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6F57_11490	COG1194	a g-specific adenine glycosylase
A6F57_11540	COG0745	RESPONSE REGULATOR receiver
A6F57_11550	COG0835	chemotaxis
A6F57_11565	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6F57_11570	COG2201	protein-glutamate methylesterase activity
A6F57_11585	COG0501	Belongs to the peptidase M48B family
A6F57_11645	COG1609	Transcriptional regulator
A6F57_11650	COG0673	inositol 2-dehydrogenase activity
A6F57_11695	COG1454	alcohol dehydrogenase
A6F57_11720	COG0051	transcription antitermination factor activity, RNA binding
A6F57_11735	COG0089	rRNA binding
A6F57_11745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6F57_11755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6F57_11770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6F57_11775	COG0438	transferase activity, transferring glycosyl groups
A6F57_11780	COG0859	PFAM glycosyl transferase family 9
A6F57_11785	COG1519	Transferase
A6F57_11810	COG0339	signal peptide processing
A6F57_11820	COG0788	formyltetrahydrofolate deformylase activity
A6F57_11830	COG1643	Atp-dependent helicase
A6F57_11835	COG2951	lytic endotransglycosylase activity
A6F57_11845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F57_11855	COG2354	Protein conserved in bacteria
A6F57_11880	COG0004	ammonium transporteR
A6F57_11885	COG0405	Gamma-glutamyltransferase
A6F57_11890	COG2837	iron assimilation
A6F57_11905	COG0540	Belongs to the ATCase OTCase family
A6F57_11930	COG3850	Histidine kinase
A6F57_11930	COG3437	response regulator, receiver
A6F57_11930	COG2205	protein histidine kinase activity
A6F57_11930	COG4999	Histidine kinase
A6F57_11955	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_11965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6F57_11975	COG0512	Glutamine amidotransferase of anthranilate synthase
A6F57_11980	COG0180	Tryptophanyl-tRNA synthetase
A6F57_11985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6F57_12005	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6F57_12015	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6F57_12050	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6F57_12055	COG0281	malic enzyme
A6F57_12060	COG0625	glutathione transferase activity
A6F57_12100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6F57_12100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6F57_12110	COG0137	argininosuccinate synthase activity
A6F57_12115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F57_12130	COG1803	Methylglyoxal synthase
A6F57_12140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6F57_12155	COG0745	RESPONSE REGULATOR receiver
A6F57_12160	COG2205	protein histidine kinase activity
A6F57_12170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6F57_12185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F57_12195	COG4942	peptidase
A6F57_12205	COG2861	carbohydrate metabolic process
A6F57_12215	COG0584	glycerophosphoryl diester phosphodiesterase
A6F57_12230	COG1162	GTPase activity
A6F57_12235	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6F57_12255	COG0457	Tetratricopeptide repeat
A6F57_12270	COG0028	Belongs to the TPP enzyme family
A6F57_12290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F57_12295	COG0805	protein transport
A6F57_12310	COG3706	GGDEF domain
A6F57_12320	COG0248	Ppx GppA phosphatase
A6F57_12325	COG0513	Belongs to the DEAD box helicase family
A6F57_12330	COG3118	belongs to the thioredoxin family
A6F57_12335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6F57_12345	COG2205	protein histidine kinase activity
A6F57_12345	COG0784	Response regulator, receiver
A6F57_12350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F57_12360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6F57_12375	COG0783	Belongs to the Dps family
A6F57_12380	COG2133	pyrroloquinoline quinone binding
A6F57_12390	COG3118	belongs to the thioredoxin family
A6F57_12400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6F57_12410	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_12425	COG1757	Na H antiporter
A6F57_12445	COG3876	Protein conserved in bacteria
A6F57_12450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6F57_12470	COG0346	lactoylglutathione lyase activity
A6F57_12540	COG4115	mRNA cleavage
A6F57_12545	COG2161	toxin-antitoxin pair type II binding
A6F57_12630	COG0183	Belongs to the thiolase family
A6F57_12635	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F57_12635	COG1024	Enoyl-CoA hydratase
A6F57_12645	COG0006	proline dipeptidase activity
A6F57_12655	COG0142	geranyltranstransferase activity
A6F57_12715	COG1238	metal cluster binding
A6F57_12725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6F57_12730	COG0585	pseudouridine synthase activity
A6F57_12745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6F57_12755	COG0840	transmembrane signaling receptor activity
A6F57_12760	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F57_12760	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F57_12760	COG0506	proline dehydrogenase activity
A6F57_12775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_12785	COG2770	Histidine kinase
A6F57_12785	COG2205	protein histidine kinase activity
A6F57_12790	COG4991	sh3 domain protein
A6F57_12795	COG3025	triphosphatase activity
A6F57_12810	COG0494	nUDIX hydrolase
A6F57_12815	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A6F57_12820	COG0730	response to heat
A6F57_12825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6F57_12830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6F57_12835	COG2201	protein-glutamate methylesterase activity
A6F57_12840	COG3706	GGDEF domain
A6F57_12845	COG0784	Response regulator, receiver
A6F57_12845	COG5002	protein histidine kinase activity
A6F57_12865	COG0564	pseudouridine synthase activity
A6F57_12875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6F57_12885	COG1802	Transcriptional regulator
A6F57_12890	COG3119	arylsulfatase activity
A6F57_12895	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_12900	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_12905	COG1063	alcohol dehydrogenase
A6F57_12915	COG2814	Major facilitator Superfamily
A6F57_12935	COG2124	cytochrome p450
A6F57_13040	COG3119	arylsulfatase activity
A6F57_13090	COG1648	precorrin-2 dehydrogenase activity
A6F57_13090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F57_13110	COG1538	Outer membrane efflux protein
A6F57_13115	COG0494	nUDIX hydrolase
A6F57_13130	COG3150	esterase
A6F57_13145	COG4251	negative regulation of phosphorylation
A6F57_13150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_13170	COG1509	lysine 2,3-aminomutase activity
A6F57_13200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F57_13215	COG0271	Belongs to the BolA IbaG family
A6F57_13220	COG0671	phosphoesterase, PA-phosphatase related
A6F57_13230	COG3707	response regulator
A6F57_13240	COG0659	secondary active sulfate transmembrane transporter activity
A6F57_13245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6F57_13250	COG2146	nitrite reductase [NAD(P)H] activity
A6F57_13255	COG0243	molybdopterin cofactor binding
A6F57_13260	COG1648	precorrin-2 dehydrogenase activity
A6F57_13260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F57_13275	COG1116	anion transmembrane transporter activity
A6F57_13275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6F57_13280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6F57_13285	COG1116	anion transmembrane transporter activity
A6F57_13300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6F57_13305	COG4206	TonB-dependent receptor
A6F57_13310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6F57_13315	COG0348	domain, Protein
A6F57_13330	COG1960	acyl-CoA dehydrogenase activity
A6F57_13335	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_13355	COG4948	Mandelate Racemase Muconate Lactonizing
A6F57_13370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_13375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_13395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F57_13400	COG0358	DNA primase activity
A6F57_13405	COG1610	YqeY-like protein
A6F57_13425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6F57_13430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6F57_13445	COG0537	adenosine 5'-monophosphoramidase activity
A6F57_13460	COG3135	benzoate transporter
A6F57_13465	COG1396	sequence-specific DNA binding
A6F57_13470	COG2974	May be involved in recombination
A6F57_13475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_13475	COG4191	Histidine kinase
A6F57_13480	COG0745	RESPONSE REGULATOR receiver
A6F57_13485	COG5002	protein histidine kinase activity
A6F57_13515	COG0811	peptide transport
A6F57_13520	COG0811	peptide transport
A6F57_13525	COG0848	biopolymer transport protein
A6F57_13530	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6F57_13540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6F57_13545	COG3437	response regulator, receiver
A6F57_13555	COG0318	PFAM AMP-dependent synthetase and ligase
A6F57_13565	COG2133	pyrroloquinoline quinone binding
A6F57_13570	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6F57_13590	COG0527	aspartate kinase activity
A6F57_13595	COG0840	transmembrane signaling receptor activity
A6F57_13600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6F57_13610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6F57_13615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6F57_13620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F57_13625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6F57_13630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6F57_13640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6F57_13660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6F57_13670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F57_13675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6F57_13680	COG3956	TIGRFAM MazG family protein
A6F57_13700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6F57_13705	COG1595	DNA-templated transcription, initiation
A6F57_13715	COG4206	TonB-dependent receptor
A6F57_13725	COG1473	amidohydrolase
A6F57_13730	COG0723	plastoquinol--plastocyanin reductase activity
A6F57_13735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6F57_13740	COG2857	Cytochrome c1
A6F57_13745	COG0625	glutathione transferase activity
A6F57_13750	COG2969	positive regulation of protein catabolic process
A6F57_13755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_13755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_13770	COG2239	Acts as a magnesium transporter
A6F57_13775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F57_13785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F57_13795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6F57_13800	COG1137	ATPase activity
A6F57_13815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6F57_13830	COG1127	ABC transporter
A6F57_13835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6F57_13840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6F57_13845	COG2854	intermembrane phospholipid transfer
A6F57_13855	COG5007	Belongs to the BolA IbaG family
A6F57_13865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6F57_13870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6F57_13880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F57_13895	COG2207	Transcriptional regulator
A6F57_13910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F57_13925	COG3300	MHYT domain
A6F57_13925	COG5001	Diguanylate cyclase
A6F57_13930	COG2205	protein histidine kinase activity
A6F57_13930	COG0784	Response regulator, receiver
A6F57_13940	COG2207	Transcriptional regulator
A6F57_13945	COG1979	alcohol dehydrogenase
A6F57_13970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6F57_13980	COG0126	phosphoglycerate kinase activity
A6F57_13985	COG3588	fructose-bisphosphate aldolase
A6F57_13990	COG1506	peptidase
A6F57_13990	COG0823	Involved in the tonB-independent uptake of proteins
A6F57_13990	COG4946	Tricorn protease homolog
A6F57_14000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6F57_14010	COG0573	inorganic phosphate transmembrane transporter activity
A6F57_14015	COG0581	inorganic phosphate transmembrane transporter activity
A6F57_14020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F57_14030	COG0306	phosphate transporter
A6F57_14040	COG0583	DNA-binding transcription factor activity
A6F57_14065	COG1272	protein, Hemolysin III
A6F57_14085	COG0477	Major facilitator Superfamily
A6F57_14090	COG2207	Transcriptional regulator
A6F57_14090	COG1609	Transcriptional regulator
A6F57_14095	COG1070	Carbohydrate kinase
A6F57_14100	COG2115	Belongs to the xylose isomerase family
A6F57_14105	COG4447	cellulose binding
A6F57_14105	COG3291	Pkd domain containing protein
A6F57_14105	COG5520	Belongs to the glycosyl hydrolase 30 family
A6F57_14110	COG2207	Transcriptional regulator
A6F57_14125	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F57_14130	COG1846	Transcriptional regulator
A6F57_14135	COG1764	response to oxidative stress
A6F57_14160	COG0420	3'-5' exonuclease activity
A6F57_14165	COG0419	ATPase involved in DNA repair
A6F57_14170	COG3706	GGDEF domain
A6F57_14180	COG2971	BadF BadG BcrA BcrD
A6F57_14185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6F57_14190	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F57_14195	COG0488	(ABC) transporter
A6F57_14230	COG4667	esterase of the alpha-beta hydrolase superfamily
A6F57_14300	COG1346	cytolysis
A6F57_14330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F57_14340	COG0513	Belongs to the DEAD box helicase family
A6F57_14350	COG3267	Type II secretory pathway component ExeA
A6F57_14350	COG3409	Peptidoglycan-binding domain 1 protein
A6F57_14360	COG3437	response regulator, receiver
A6F57_14360	COG0784	Response regulator, receiver
A6F57_14365	COG0066	3-isopropylmalate dehydratase activity
A6F57_14375	COG0473	3-isopropylmalate dehydrogenase activity
A6F57_14380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F57_14410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6F57_14425	COG4555	ABC transporter
A6F57_14430	COG1668	transmembrane transport
A6F57_14450	COG4133	protoheme IX ABC transporter activity
A6F57_14455	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F57_14460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F57_14465	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F57_14475	COG1138	Cytochrome C-type biogenesis protein
A6F57_14480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F57_14495	COG2853	Lipoprotein
A6F57_14500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6F57_14510	COG3104	oligopeptide transport
A6F57_14525	COG1682	transport, permease protein
A6F57_14555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6F57_14560	COG1555	photosystem II stabilization
A6F57_14560	COG1596	polysaccharide export
A6F57_14565	COG0473	3-isopropylmalate dehydrogenase activity
A6F57_14580	COG1611	Belongs to the LOG family
A6F57_14585	COG0745	RESPONSE REGULATOR receiver
A6F57_14585	COG3706	GGDEF domain
A6F57_14590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F57_14590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F57_14660	COG0564	pseudouridine synthase activity
A6F57_14680	COG0024	Methionine aminopeptidase
A6F57_14685	COG0052	Belongs to the universal ribosomal protein uS2 family
A6F57_14695	COG0528	UMP kinase activity
A6F57_14705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6F57_14710	COG0575	Belongs to the CDS family
A6F57_14715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6F57_14720	COG0750	zinc metalloprotease
A6F57_14735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F57_14740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6F57_14755	COG0587	DNA-directed DNA polymerase activity
A6F57_14760	COG0825	malonyl-CoA metabolic process
A6F57_14765	COG0037	tRNA processing
A6F57_14785	COG0590	tRNA wobble adenosine to inosine editing
A6F57_14795	COG0047	phosphoribosylformylglycinamidine synthase activity
A6F57_14795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F57_14800	COG2840	Smr protein MutS2
A6F57_14820	COG2885	chlorophyll binding
A6F57_14830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_14835	COG2197	response regulator
A6F57_14875	COG0835	chemotaxis
A6F57_14875	COG0784	Response regulator, receiver
A6F57_14880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6F57_14885	COG1815	bacterial-type flagellum-dependent cell motility
A6F57_14890	COG1558	bacterial-type flagellum-dependent cell motility
A6F57_14895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6F57_14900	COG1749	Flagellar hook protein flgE
A6F57_14905	COG4787	bacterial-type flagellum-dependent cell motility
A6F57_14910	COG4786	Flagellar basal body rod
A6F57_14925	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6F57_14925	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6F57_14930	COG1256	bacterial-type flagellum assembly
A6F57_14950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6F57_14955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6F57_14985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F57_14990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6F57_15005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6F57_15030	COG2089	acid synthase
A6F57_15060	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_15065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6F57_15080	COG2089	acid synthase
A6F57_15090	COG1083	cytidylyl-transferase
A6F57_15095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6F57_15100	COG1086	Polysaccharide biosynthesis protein
A6F57_15110	COG2204	response regulator
A6F57_15115	COG3852	Histidine kinase
A6F57_15120	COG2204	response regulator
A6F57_15130	COG1766	The M ring may be actively involved in energy transduction
A6F57_15135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6F57_15185	COG1987	bacterial-type flagellum assembly
A6F57_15200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6F57_15210	COG0455	bacterial-type flagellum organization
A6F57_15225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6F57_15230	COG0643	Histidine kinase
A6F57_15230	COG2198	Histidine kinase
A6F57_15235	COG2201	protein-glutamate methylesterase activity
A6F57_15240	COG1192	Involved in chromosome partitioning
A6F57_15250	COG0835	chemotaxis
A6F57_15265	COG1410	methionine synthase
A6F57_15265	COG0646	methionine synthase
A6F57_15280	COG0583	DNA-binding transcription factor activity
A6F57_15285	COG0583	DNA-binding transcription factor activity
A6F57_15290	COG0288	reversible hydration of carbon dioxide
A6F57_15295	COG0659	secondary active sulfate transmembrane transporter activity
A6F57_15305	COG1309	transcriptional regulator
A6F57_15310	COG3590	peptidase
A6F57_15350	COG1607	acyl-coa hydrolase
A6F57_15365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6F57_15370	COG4172	Belongs to the ABC transporter superfamily
A6F57_15375	COG4172	Belongs to the ABC transporter superfamily
A6F57_15380	COG4171	peptide transport system, permease
A6F57_15385	COG4168	peptide transport system, permease
A6F57_15390	COG0747	negative chemotaxis
A6F57_15395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6F57_15400	COG1842	Phage shock protein A
A6F57_15430	COG0625	glutathione transferase activity
A6F57_15435	COG1522	sequence-specific DNA binding
A6F57_15440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6F57_15465	COG0457	Tetratricopeptide repeat
A6F57_15505	COG0811	peptide transport
A6F57_15510	COG0811	peptide transport
A6F57_15515	COG0848	biopolymer transport protein
A6F57_15570	COG0456	acetyltransferase
A6F57_15585	COG0583	DNA-binding transcription factor activity
A6F57_15615	COG2175	clavaminate synthase activity
A6F57_15640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6F57_15645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6F57_15650	COG0564	pseudouridine synthase activity
A6F57_15660	COG0612	Peptidase, M16
A6F57_15685	COG1136	(ABC) transporter
A6F57_15715	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F57_15735	COG2719	SpoVR family
A6F57_15740	COG2718	Belongs to the UPF0229 family
A6F57_15745	COG2766	serine protein kinase
A6F57_15755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6F57_15760	COG4771	TonB-dependent receptor
A6F57_15785	COG0450	alkyl hydroperoxide reductase
A6F57_15790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F57_15795	COG2885	chlorophyll binding
A6F57_15800	COG0584	glycerophosphoryl diester phosphodiesterase
A6F57_15805	COG0346	lactoylglutathione lyase activity
A6F57_15810	COG1278	Cold shock
A6F57_15835	COG0823	Involved in the tonB-independent uptake of proteins
A6F57_15835	COG1506	peptidase
A6F57_15835	COG4946	Tricorn protease homolog
A6F57_15840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F57_15845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F57_15850	COG4660	Part of a membrane complex involved in electron transport
A6F57_15860	COG4658	electron transport chain
A6F57_15865	COG4656	Part of a membrane complex involved in electron transport
A6F57_15870	COG2878	Part of a membrane complex involved in electron transport
A6F57_15875	COG4657	Part of a membrane complex involved in electron transport
A6F57_15890	COG0534	Mate efflux family protein
A6F57_15895	COG0556	nucleotide-excision repair
A6F57_15920	COG0602	queuosine metabolic process
A6F57_15930	COG0367	asparagine synthase
A6F57_15955	COG3273	potassium ion transport
A6F57_15955	COG0471	metal ion transport
A6F57_15970	COG0529	Catalyzes the synthesis of activated sulfate
A6F57_15975	COG0175	sulfate reduction
A6F57_15980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_15985	COG3706	GGDEF domain
A6F57_16010	COG2304	oxidoreductase activity
A6F57_16030	COG0714	Associated with various cellular activities
A6F57_16040	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F57_16040	COG1024	Enoyl-CoA hydratase
A6F57_16055	COG1025	Belongs to the peptidase M16 family
A6F57_16060	COG2062	phosphohistidine phosphatase, SixA
A6F57_16070	COG4536	flavin adenine dinucleotide binding
A6F57_16075	COG4137	Cytochrome C assembly protein
A6F57_16080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6F57_16110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6F57_16120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_16125	COG1132	(ABC) transporter
A6F57_16145	COG0228	four-way junction DNA binding
A6F57_16150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6F57_16155	COG0336	Belongs to the RNA methyltransferase TrmD family
A6F57_16160	COG0335	large ribosomal subunit rRNA binding
A6F57_16175	COG2860	membrane
A6F57_16180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6F57_16185	COG0287	Prephenate dehydrogenase
A6F57_16185	COG1605	Chorismate mutase
A6F57_16190	COG0840	transmembrane signaling receptor activity
A6F57_16195	COG0077	Prephenate dehydratase
A6F57_16195	COG1605	Chorismate mutase
A6F57_16200	COG0745	RESPONSE REGULATOR receiver
A6F57_16205	COG0023	Translation Initiation Factor
A6F57_16215	COG0745	RESPONSE REGULATOR receiver
A6F57_16215	COG3706	GGDEF domain
A6F57_16235	COG2205	protein histidine kinase activity
A6F57_16245	COG2204	response regulator
A6F57_16260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6F57_16280	COG2255	four-way junction helicase activity
A6F57_16285	COG0824	Thioesterase
A6F57_16290	COG0811	peptide transport
A6F57_16305	COG0823	Involved in the tonB-independent uptake of proteins
A6F57_16310	COG2885	chlorophyll binding
A6F57_16315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6F57_16335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6F57_16390	COG3706	GGDEF domain
A6F57_16390	COG0745	RESPONSE REGULATOR receiver
A6F57_16400	COG0024	Methionine aminopeptidase
A6F57_16440	COG0784	Response regulator, receiver
A6F57_16440	COG2205	protein histidine kinase activity
A6F57_16445	COG2271	Major facilitator Superfamily
A6F57_16475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F57_16485	COG3038	cytochrome b561
A6F57_16490	COG0583	DNA-binding transcription factor activity
A6F57_16505	COG0517	IMP dehydrogenase activity
A6F57_16510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F57_16520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_16530	COG1309	transcriptional regulator
A6F57_16535	COG0583	DNA-binding transcription factor activity
A6F57_16555	COG3706	GGDEF domain
A6F57_16565	COG3008	intermembrane lipid transfer
A6F57_16565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6F57_16570	COG2995	paraquat-inducible protein a
A6F57_16580	COG0017	Asparaginyl-tRNA synthetase
A6F57_16595	COG0189	ligase activity
A6F57_16600	COG0456	acetyltransferase
A6F57_16625	COG0156	8-amino-7-oxononanoate synthase activity
A6F57_16630	COG2226	methyltransferase
A6F57_16630	COG1073	alpha beta
A6F57_16645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F57_16650	COG4139	cobalamin transport
A6F57_16660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6F57_16675	COG5265	(ABC) transporter
A6F57_16680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6F57_16690	COG0745	RESPONSE REGULATOR receiver
A6F57_16710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F57_16750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F57_16770	COG4181	ATPase activity
A6F57_16775	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6F57_16785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6F57_16790	COG0628	permease
A6F57_16795	COG2205	protein histidine kinase activity
A6F57_16800	COG0745	RESPONSE REGULATOR receiver
A6F57_16815	COG2350	Protein conserved in bacteria
A6F57_16820	COG0159	tryptophan synthase activity
A6F57_16830	COG0134	indole-3-glycerol-phosphate synthase activity
A6F57_16830	COG0135	phosphoribosylanthranilate isomerase activity
A6F57_16835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6F57_16845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F57_16850	COG0613	PHP domain protein
A6F57_16855	COG0009	L-threonylcarbamoyladenylate synthase
A6F57_16860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6F57_16865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6F57_16880	COG0656	L-ascorbic acid biosynthetic process
A6F57_16885	COG0110	maltose O-acetyltransferase activity
A6F57_16900	COG2733	membrane
A6F57_16905	COG0500	methyltransferase
A6F57_16910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F57_16915	COG0497	DNA recombination
A6F57_16925	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_16935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F57_16940	COG2610	gluconate transmembrane transporter activity
A6F57_16945	COG4771	TonB-dependent receptor
A6F57_16955	COG0784	Response regulator, receiver
A6F57_16955	COG2205	protein histidine kinase activity
A6F57_16960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6F57_16970	COG0484	heat shock protein binding
A6F57_16975	COG3909	cytochrome
A6F57_16980	COG5001	Diguanylate cyclase
A6F57_16980	COG3706	GGDEF domain
A6F57_16980	COG4251	negative regulation of phosphorylation
A6F57_16980	COG2203	Gaf domain
A6F57_16995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6F57_17000	COG0505	Belongs to the CarA family
A6F57_17005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6F57_17010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F57_17035	COG0071	Belongs to the small heat shock protein (HSP20) family
A6F57_17040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6F57_17045	COG0280	phosphate acetyltransferase
A6F57_17045	COG0857	belongs to the CobB CobQ family
A6F57_17050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6F57_17055	COG4535	Mg2 and Co2 transporter CorC
A6F57_17065	COG1702	phosphate starvation-inducible protein PhoH
A6F57_17075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F57_17090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6F57_17095	COG1115	amino acid carrier protein
A6F57_17120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F57_17125	COG0012	GTP binding
A6F57_17140	COG1064	alcohol dehydrogenase
A6F57_17150	COG5001	Diguanylate cyclase
A6F57_17150	COG3300	MHYT domain
A6F57_17155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6F57_17165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6F57_17170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6F57_17175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6F57_17185	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F57_17190	COG0784	Response regulator, receiver
A6F57_17190	COG3437	response regulator, receiver
A6F57_17195	COG3094	Invasion gene expression up-regulator, SirB
A6F57_17210	COG0583	DNA-binding transcription factor activity
A6F57_17235	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A6F57_17240	COG0515	serine threonine protein kinase
A6F57_17240	COG2815	serine threonine protein kinase
A6F57_17245	COG2116	formate transmembrane transporter activity
A6F57_17260	COG0714	Associated with various cellular activities
A6F57_17265	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6F57_17270	COG0033	Phosphoglucomutase
A6F57_17275	COG0058	SHG alpha-glucan phosphorylase activity
A6F57_17285	COG2988	succinylglutamate desuccinylase activity
A6F57_17315	COG1393	Belongs to the ArsC family
A6F57_17320	COG2211	Major facilitator Superfamily
A6F57_17320	COG2190	(PTS) system
A6F57_17345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6F57_17360	COG3706	GGDEF domain
A6F57_17380	COG3447	MASE1 domain protein
A6F57_17380	COG5001	Diguanylate cyclase
A6F57_17380	COG5002	protein histidine kinase activity
A6F57_17390	COG0402	S-adenosylhomocysteine deaminase activity
A6F57_17395	COG2351	hydroxyisourate hydrolase activity
A6F57_17410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6F57_17420	COG1309	transcriptional regulator
A6F57_17435	COG2252	PERMEase
A6F57_17440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6F57_17450	COG5001	Diguanylate cyclase
A6F57_17450	COG3300	MHYT domain
A6F57_17455	COG3706	GGDEF domain
A6F57_17455	COG0745	RESPONSE REGULATOR receiver
A6F57_17460	COG2205	protein histidine kinase activity
A6F57_17460	COG0784	Response regulator, receiver
A6F57_17475	COG2233	PERMEase
A6F57_17480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6F57_17495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6F57_17500	COG0730	response to heat
A6F57_17540	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_17550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6F57_17570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F57_17580	COG1596	polysaccharide export
A6F57_17585	COG0489	protein tyrosine kinase activity
A6F57_17590	COG4464	protein tyrosine phosphatase activity
A6F57_17625	COG0438	transferase activity, transferring glycosyl groups
A6F57_17670	COG0438	transferase activity, transferring glycosyl groups
A6F57_17695	COG0072	phenylalanine-tRNA ligase activity
A6F57_17695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_17710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6F57_17720	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F57_17730	COG2096	Adenosyltransferase
A6F57_17740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6F57_17750	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6F57_17765	COG0708	Exodeoxyribonuclease III
A6F57_17800	COG2814	Major facilitator Superfamily
A6F57_17815	COG1957	nucleoside hydrolase
A6F57_17850	COG1024	Enoyl-CoA hydratase
A6F57_17855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F57_17860	COG1960	acyl-CoA dehydrogenase activity
A6F57_17865	COG0789	Transcriptional regulator
A6F57_17870	COG0183	Belongs to the thiolase family
A6F57_17885	COG2925	Exonuclease
A6F57_17890	COG4999	Histidine kinase
A6F57_17890	COG3850	Histidine kinase
A6F57_17890	COG2205	protein histidine kinase activity
A6F57_17890	COG3437	response regulator, receiver
A6F57_17930	COG1643	Atp-dependent helicase
A6F57_17955	COG0328	RNA-DNA hybrid ribonuclease activity
A6F57_17960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F57_17990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6F57_17995	COG1136	(ABC) transporter
A6F57_18000	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6F57_18005	COG1301	dicarboxylic acid transport
A6F57_18015	COG3724	N-succinylarginine dihydrolase activity
A6F57_18020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6F57_18030	COG0583	DNA-binding transcription factor activity
A6F57_18040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6F57_18055	COG0625	glutathione transferase activity
A6F57_18075	COG2153	protein acetylation
A6F57_18095	COG1530	ribonuclease E activity
A6F57_18105	COG0546	phosphoglycolate phosphatase activity
A6F57_18110	COG0424	maF-like protein
A6F57_18115	COG1399	metal-binding, possibly nucleic acid-binding protein
A6F57_18125	COG0416	fatty acid biosynthetic process
A6F57_18130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6F57_18145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F57_18150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6F57_18155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6F57_18160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6F57_18170	COG0470	DNA polymerase III
A6F57_18175	COG0084	hydrolase, TatD family'
A6F57_18185	COG0702	epimerase
A6F57_18190	COG0745	RESPONSE REGULATOR receiver
A6F57_18190	COG3706	GGDEF domain
A6F57_18210	COG1714	RDD family
A6F57_18230	COG1942	4-Oxalocrotonate Tautomerase
A6F57_18250	COG0574	Belongs to the PEP-utilizing enzyme family
A6F57_18250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6F57_18270	COG0679	Auxin Efflux Carrier
A6F57_18275	COG1609	Transcriptional regulator
A6F57_18290	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_18300	COG3265	gluconokinase activity
A6F57_18345	COG1695	Transcriptional regulator
A6F57_18385	COG2801	Transposase and inactivated derivatives
A6F57_18400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6F57_18405	COG3123	guanosine phosphorylase activity
A6F57_18410	COG0277	FAD linked oxidase domain protein
A6F57_18410	COG0247	lactate metabolic process
A6F57_18425	COG2850	peptidyl-arginine hydroxylation
A6F57_18435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6F57_18440	COG2915	High frequency lysogenization protein hflD homolog
A6F57_18445	COG0482	sulfurtransferase activity
A6F57_18450	COG1187	pseudouridine synthase activity
A6F57_18460	COG1278	Cold shock
A6F57_18465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6F57_18470	COG0542	response to heat
A6F57_18475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F57_18480	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6F57_18490	COG0492	ferredoxin-NADP+ reductase activity
A6F57_18505	COG3091	SprT-like family
A6F57_18510	COG0616	signal peptide processing
A6F57_18525	COG0778	Nitroreductase
A6F57_18535	COG0252	asparaginase activity
A6F57_18545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6F57_18550	COG0321	lipoyl(octanoyl) transferase activity
A6F57_18555	COG2921	Belongs to the UPF0250 family
A6F57_18560	COG1686	Belongs to the peptidase S11 family
A6F57_18565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F57_18570	COG0772	Belongs to the SEDS family
A6F57_18580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6F57_18585	COG0799	negative regulation of ribosome biogenesis
A6F57_18590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6F57_18595	COG1466	dna polymerase III delta subunit
A6F57_18605	COG0495	leucyl-tRNA aminoacylation
A6F57_18610	COG1067	ATP-dependent peptidase activity
A6F57_18620	COG1534	Rna-binding protein
A6F57_18625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F57_18630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F57_18635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6F57_18640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F57_18645	COG0149	triose-phosphate isomerase activity
A6F57_18650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6F57_18690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_18715	COG1185	polyribonucleotide nucleotidyltransferase activity
A6F57_18725	COG1119	ATPase activity
A6F57_18730	COG0454	-acetyltransferase
A6F57_18740	COG4628	conserved protein (DUF2132)
A6F57_18785	COG1238	metal cluster binding
A6F57_18795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6F57_18805	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F57_18810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6F57_18815	COG0436	Aminotransferase
A6F57_18840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_18845	COG1765	OsmC-like protein
A6F57_18850	COG2996	Protein conserved in bacteria
A6F57_18855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6F57_18865	COG1984	allophanate hydrolase subunit 2
A6F57_18875	COG1609	Transcriptional regulator
A6F57_18880	COG3265	gluconokinase activity
A6F57_18900	COG0716	FMN binding
A6F57_18910	COG0596	Alpha beta hydrolase
A6F57_18960	COG1917	Cupin 2, conserved barrel domain protein
A6F57_18960	COG2207	Transcriptional regulator
A6F57_18965	COG1960	acyl-CoA dehydrogenase activity
A6F57_18975	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_18980	COG1671	Belongs to the UPF0178 family
A6F57_18985	COG1448	Aminotransferase
A6F57_19020	COG1024	Enoyl-CoA hydratase
A6F57_19025	COG0405	Gamma-glutamyltransferase
A6F57_19035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6F57_19055	COG0534	Mate efflux family protein
A6F57_19060	COG0303	'Molybdopterin
A6F57_19070	COG1215	transferase activity, transferring glycosyl groups
A6F57_19075	COG3769	mannosylglycerate metabolic process
A6F57_19080	COG0572	uridine kinase
A6F57_19115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6F57_19150	COG1393	Belongs to the ArsC family
A6F57_19160	COG4783	chaperone-mediated protein folding
A6F57_19170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F57_19180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6F57_19185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6F57_19220	COG1131	(ABC) transporter
A6F57_19375	COG5002	protein histidine kinase activity
A6F57_19380	COG0633	Ferredoxin
A6F57_19385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F57_19390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F57_19405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6F57_19410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6F57_19415	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6F57_19420	COG0539	negative regulation of cytoplasmic translation
A6F57_19425	COG0776	regulation of translation
A6F57_19435	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6F57_19440	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6F57_19445	COG0284	orotidine-5'-phosphate decarboxylase activity
A6F57_19450	COG0686	Belongs to the AlaDH PNT family
A6F57_19460	COG0531	amino acid
A6F57_19460	COG1674	ftsk spoiiie
A6F57_19465	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6F57_19470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F57_19485	COG0561	phosphatase activity
A6F57_19490	COG2920	part of a sulfur-relay system
A6F57_19500	COG2923	Belongs to the DsrF TusC family
A6F57_19510	COG0670	Belongs to the BI1 family
A6F57_19535	COG0745	RESPONSE REGULATOR receiver
A6F57_19540	COG0642	Histidine kinase
A6F57_19570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F57_19590	COG2197	response regulator
A6F57_19595	COG0322	excinuclease ABC activity
A6F57_19670	COG5532	Uncharacterized conserved protein (DUF2303)
A6F57_19685	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6F57_19895	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6F57_19900	COG2897	thiosulfate sulfurtransferase activity
A6F57_19905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6F57_19910	COG1280	lysine exporter protein (LysE YggA)
A6F57_19930	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F57_19935	COG0037	tRNA processing
A6F57_19945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F57_19960	COG2217	Heavy metal translocating P-type atpase
A6F57_19970	COG2010	Cytochrome c
A6F57_19985	COG3278	Belongs to the heme-copper respiratory oxidase family
A6F57_19995	COG2193	ferroxidase activity
A6F57_20010	COG0069	glutamate synthase activity
A6F57_20020	COG0589	response to stress
A6F57_20025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6F57_20080	COG3046	protein related to deoxyribodipyrimidine photolyase
A6F57_20085	COG0415	Belongs to the DNA photolyase family
A6F57_20090	COG0415	Belongs to the DNA photolyase family
A6F57_20100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F57_20105	COG3130	regulation of translation
A6F57_20130	COG0167	dihydroorotate dehydrogenase activity
A6F57_20135	COG2902	Dehydrogenase
A6F57_20165	COG0308	aminopeptidase N
A6F57_20175	COG0733	neurotransmitter:sodium symporter activity
A6F57_20180	COG0793	Belongs to the peptidase S41A family
A6F57_20195	COG1956	GAF domain-containing protein
A6F57_20205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6F57_20215	COG1946	Acyl-CoA thioesterase
A6F57_20220	COG0515	serine threonine protein kinase
A6F57_20225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6F57_20230	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F57_20235	COG0022	dehydrogenase e1 component
A6F57_20240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F57_20245	COG1404	Belongs to the peptidase S8 family
A6F57_20250	COG1322	Protein conserved in bacteria
A6F57_20260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F57_20265	COG0494	nUDIX hydrolase
A6F57_20270	COG1760	l-serine dehydratase
A6F57_20290	COG0583	DNA-binding transcription factor activity
A6F57_20295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6F57_20300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit