locus-tag	class	description
ALE3EI_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ALE3EI_0002	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ALE3EI_0007	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ALE3EI_0009	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ALE3EI_0010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALE3EI_0012	COG0456	acetyltransferase
ALE3EI_0014	COG0336	Belongs to the RNA methyltransferase TrmD family
ALE3EI_0016	COG0335	large ribosomal subunit rRNA binding
ALE3EI_0018	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ALE3EI_0021	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ALE3EI_0022	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ALE3EI_0023	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ALE3EI_0024	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ALE3EI_0028	COG0492	ferredoxin-NADP+ reductase activity
ALE3EI_0033	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALE3EI_0033	COG1333	cytochrome c biogenesis protein
ALE3EI_0034	COG0305	Participates in initiation and elongation during chromosome replication
ALE3EI_0035	COG0825	malonyl-CoA metabolic process
ALE3EI_0038	COG0343	queuine tRNA-ribosyltransferase activity
ALE3EI_0040	COG3958	Transketolase
ALE3EI_0043	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ALE3EI_0044	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ALE3EI_0046	COG1233	COG1233 Phytoene dehydrogenase and related
ALE3EI_0050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_0052	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ALE3EI_0053	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ALE3EI_0053	COG2755	lipolytic protein G-D-S-L family
ALE3EI_0055	COG0714	Associated with various cellular activities
ALE3EI_0056	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALE3EI_0062	COG0516	GMP reductase activity
ALE3EI_0062	COG0517	IMP dehydrogenase activity
ALE3EI_0065	COG1730	sister chromatid segregation
ALE3EI_0067	COG0737	Belongs to the 5'-nucleotidase family
ALE3EI_0069	COG1280	lysine exporter protein (LysE YggA)
ALE3EI_0070	COG0167	dihydroorotate dehydrogenase activity
ALE3EI_0071	COG2195	Cleaves the N-terminal amino acid of tripeptides
ALE3EI_0072	COG1862	Preprotein translocase
ALE3EI_0074	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALE3EI_0075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ALE3EI_0076	COG1132	(ABC) transporter
ALE3EI_0079	COG0659	secondary active sulfate transmembrane transporter activity
ALE3EI_0086	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALE3EI_0089	COG2318	DinB family
ALE3EI_0090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALE3EI_0091	COG0514	ATP-dependent DNA helicase (RecQ)
ALE3EI_0092	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ALE3EI_0092	COG0517	IMP dehydrogenase activity
ALE3EI_0093	COG0805	protein transport
ALE3EI_0095	COG1137	ATPase activity
ALE3EI_0096	COG1183	phosphatidylcholine synthase activity
ALE3EI_0099	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALE3EI_0104	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_0108	COG1083	cytidylyl-transferase
ALE3EI_0109	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ALE3EI_0110	COG2089	acid synthase
ALE3EI_0111	COG0297	glycogen (starch) synthase activity
ALE3EI_0116	COG0463	Glycosyl transferase, family 2
ALE3EI_0118	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ALE3EI_0119	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ALE3EI_0120	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_0122	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_0130	COG2852	Protein conserved in bacteria
ALE3EI_0132	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALE3EI_0136	COG0488	(ABC) transporter
ALE3EI_0138	COG1136	(ABC) transporter
ALE3EI_0138	COG0577	efflux transmembrane transporter activity
ALE3EI_0143	COG0653	protein targeting
ALE3EI_0154	COG1595	DNA-templated transcription, initiation
ALE3EI_0156	COG1764	response to oxidative stress
ALE3EI_0157	COG1703	isobutyryl-CoA mutase activity
ALE3EI_0158	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ALE3EI_0159	COG0463	Glycosyl transferase, family 2
ALE3EI_0162	COG0671	phosphoesterase, PA-phosphatase related
ALE3EI_0164	COG0534	Mate efflux family protein
ALE3EI_0168	COG2326	polyphosphate kinase activity
ALE3EI_0169	COG2204	response regulator
ALE3EI_0171	COG3264	Mechanosensitive ion channel
ALE3EI_0171	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ALE3EI_0172	COG1668	transmembrane transport
ALE3EI_0173	COG4152	abc transporter atp-binding protein
ALE3EI_0174	COG0484	heat shock protein binding
ALE3EI_0175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ALE3EI_0178	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ALE3EI_0178	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALE3EI_0180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALE3EI_0184	COG4585	Histidine kinase
ALE3EI_0185	COG2197	response regulator
ALE3EI_0189	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALE3EI_0193	COG1522	sequence-specific DNA binding
ALE3EI_0195	COG1703	isobutyryl-CoA mutase activity
ALE3EI_0195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_0195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_0200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ALE3EI_0201	COG0284	orotidine-5'-phosphate decarboxylase activity
ALE3EI_0202	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ALE3EI_0203	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ALE3EI_0205	COG1462	curli production assembly transport component CsgG
ALE3EI_0214	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALE3EI_0219	COG2264	protein methyltransferase activity
ALE3EI_0220	COG0149	triose-phosphate isomerase activity
ALE3EI_0221	COG0601	transmembrane transport
ALE3EI_0224	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ALE3EI_0225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ALE3EI_0227	COG1132	(ABC) transporter
ALE3EI_0228	COG0101	tRNA pseudouridine synthase activity
ALE3EI_0237	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ALE3EI_0239	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ALE3EI_0239	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ALE3EI_0240	COG0799	negative regulation of ribosome biogenesis
ALE3EI_0241	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALE3EI_0244	COG0688	phosphatidylethanolamine metabolic process
ALE3EI_0247	COG0525	valine-tRNA ligase activity
ALE3EI_0249	COG0750	zinc metalloprotease
ALE3EI_0250	COG0436	Aminotransferase
ALE3EI_0251	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ALE3EI_0252	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ALE3EI_0257	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ALE3EI_0258	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALE3EI_0260	COG1663	tetraacyldisaccharide 4'-kinase activity
ALE3EI_0261	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ALE3EI_0264	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ALE3EI_0270	COG3844	kynureninase activity
ALE3EI_0271	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALE3EI_0274	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_0277	COG0671	phosphoesterase, PA-phosphatase related
ALE3EI_0278	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALE3EI_0283	COG3340	Belongs to the peptidase S51 family
ALE3EI_0284	COG1876	peptidase activity
ALE3EI_0285	COG0501	Belongs to the peptidase M48B family
ALE3EI_0286	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ALE3EI_0289	COG2226	methyltransferase
ALE3EI_0290	COG1477	protein flavinylation
ALE3EI_0294	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ALE3EI_0296	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ALE3EI_0297	COG1805	sodium ion transport
ALE3EI_0301	COG2967	ApaG domain
ALE3EI_0304	COG0745	RESPONSE REGULATOR receiver
ALE3EI_0304	COG3292	Two component regulator propeller
ALE3EI_0304	COG2205	protein histidine kinase activity
ALE3EI_0306	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_0308	COG0357	Ribosomal RNA small subunit methyltransferase G
ALE3EI_0309	COG3239	Fatty acid desaturase
ALE3EI_0314	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ALE3EI_0316	COG0569	domain protein
ALE3EI_0317	COG2226	methyltransferase
ALE3EI_0321	COG0191	fructose-bisphosphate aldolase activity
ALE3EI_0322	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ALE3EI_0324	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ALE3EI_0325	COG1185	polyribonucleotide nucleotidyltransferase activity
ALE3EI_0330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALE3EI_0332	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ALE3EI_0341	COG1610	YqeY-like protein
ALE3EI_0342	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ALE3EI_0345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALE3EI_0346	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ALE3EI_0347	COG0772	Belongs to the SEDS family
ALE3EI_0348	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALE3EI_0349	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALE3EI_0350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALE3EI_0351	COG0768	penicillin binding
ALE3EI_0353	COG0275	rRNA processing
ALE3EI_0354	COG2001	Belongs to the MraZ family
ALE3EI_0356	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ALE3EI_0359	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ALE3EI_0360	COG2197	response regulator
ALE3EI_0361	COG0358	DNA primase activity
ALE3EI_0371	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ALE3EI_0373	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ALE3EI_0379	COG1490	D-aminoacyl-tRNA deacylase activity
ALE3EI_0380	COG1162	GTPase activity
ALE3EI_0381	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ALE3EI_0387	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALE3EI_0388	COG1959	2 iron, 2 sulfur cluster binding
ALE3EI_0389	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ALE3EI_0391	COG0646	methionine synthase
ALE3EI_0391	COG1410	methionine synthase
ALE3EI_0392	COG1765	OsmC-like protein
ALE3EI_0393	COG0527	aspartate kinase activity
ALE3EI_0393	COG0460	homoserine dehydrogenase
ALE3EI_0394	COG0626	cystathionine gamma-synthase activity
ALE3EI_0396	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ALE3EI_0398	COG2197	response regulator
ALE3EI_0408	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ALE3EI_0415	COG1160	GTP binding
ALE3EI_0416	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ALE3EI_0425	COG0730	response to heat
ALE3EI_0429	COG0745	RESPONSE REGULATOR receiver
ALE3EI_0430	COG5002	protein histidine kinase activity
ALE3EI_0434	COG4585	Histidine kinase
ALE3EI_0447	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALE3EI_0448	COG1401	restriction endodeoxyribonuclease activity
ALE3EI_0458	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALE3EI_0472	COG0488	(ABC) transporter
ALE3EI_0474	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ALE3EI_0474	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALE3EI_0478	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALE3EI_0483	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALE3EI_0488	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ALE3EI_0489	COG0459	protein refolding
ALE3EI_0493	COG2217	Heavy metal translocating P-type atpase
ALE3EI_0494	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALE3EI_0503	COG0138	bifunctional purine biosynthesis protein purh
ALE3EI_0504	COG1077	Cell shape determining protein MreB Mrl
ALE3EI_0507	COG0768	penicillin binding
ALE3EI_0508	COG0772	Belongs to the SEDS family
ALE3EI_0510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALE3EI_0513	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ALE3EI_0515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_0516	COG0791	NLP P60 protein
ALE3EI_0517	COG0658	competence protein
ALE3EI_0517	COG2333	competence protein COMEC
ALE3EI_0519	COG3104	oligopeptide transport
ALE3EI_0520	COG3104	oligopeptide transport
ALE3EI_0521	COG1506	peptidase
ALE3EI_0521	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_0525	COG1253	flavin adenine dinucleotide binding
ALE3EI_0530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ALE3EI_0533	COG3483	tryptophan 2,3-dioxygenase activity
ALE3EI_0537	COG1054	Belongs to the UPF0176 family
ALE3EI_0539	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ALE3EI_0541	COG0306	phosphate transporter
ALE3EI_0548	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALE3EI_0551	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_0553	COG2234	aminopeptidase activity
ALE3EI_0557	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALE3EI_0557	COG3153	acetyltransferase
ALE3EI_0559	COG0010	Belongs to the arginase family
ALE3EI_0560	COG1166	arginine decarboxylase activity
ALE3EI_0562	COG1187	pseudouridine synthase activity
ALE3EI_0574	COG2081	HI0933 family
ALE3EI_0576	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ALE3EI_0577	COG0463	Glycosyl transferase, family 2
ALE3EI_0580	COG2824	Alkylphosphonate utilization operon protein PhnA
ALE3EI_0590	COG2315	Protein conserved in bacteria
ALE3EI_0594	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALE3EI_0595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ALE3EI_0611	COG1704	LemA family
ALE3EI_0615	COG0740	serine-type endopeptidase activity
ALE3EI_0623	COG0228	four-way junction DNA binding
ALE3EI_0624	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ALE3EI_0625	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ALE3EI_0626	COG0531	amino acid
ALE3EI_0631	COG0492	ferredoxin-NADP+ reductase activity
ALE3EI_0633	COG0489	protein tyrosine kinase activity
ALE3EI_0634	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALE3EI_0636	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ALE3EI_0637	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ALE3EI_0638	COG5002	protein histidine kinase activity
ALE3EI_0639	COG0745	RESPONSE REGULATOR receiver
ALE3EI_0644	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ALE3EI_0647	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALE3EI_0648	COG1216	Glycosyl transferase, family 2
ALE3EI_0651	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ALE3EI_0652	COG2363	Small membrane protein
ALE3EI_0654	COG2738	Putative neutral zinc metallopeptidase
ALE3EI_0655	COG0495	leucyl-tRNA aminoacylation
ALE3EI_0656	COG2177	Part of the ABC transporter FtsEX involved in
ALE3EI_0659	COG1968	undecaprenyl-diphosphatase activity
ALE3EI_0660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ALE3EI_0662	COG0519	Catalyzes the synthesis of GMP from XMP
ALE3EI_0664	COG2957	Belongs to the agmatine deiminase family
ALE3EI_0665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALE3EI_0667	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ALE3EI_0668	COG3852	Histidine kinase
ALE3EI_0671	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALE3EI_0674	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ALE3EI_0677	COG3201	nicotinamide mononucleotide transporter
ALE3EI_0679	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ALE3EI_0681	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ALE3EI_0683	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALE3EI_0684	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALE3EI_0689	COG0629	single-stranded DNA binding
ALE3EI_0690	COG1194	a g-specific adenine glycosylase
ALE3EI_0691	COG0776	regulation of translation
ALE3EI_0692	COG1530	ribonuclease E activity
ALE3EI_0696	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ALE3EI_0697	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALE3EI_0699	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ALE3EI_0700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ALE3EI_0701	COG0156	8-amino-7-oxononanoate synthase activity
ALE3EI_0703	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ALE3EI_0704	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALE3EI_0706	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALE3EI_0708	COG0297	glycogen (starch) synthase activity
ALE3EI_0709	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ALE3EI_0710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ALE3EI_0719	COG2197	response regulator
ALE3EI_0720	COG4585	Histidine kinase
ALE3EI_0722	COG4566	intracellular signal transduction
ALE3EI_0723	COG2197	response regulator
ALE3EI_0725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ALE3EI_0727	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_0728	COG0667	Aldo Keto reductase
ALE3EI_0729	COG2885	chlorophyll binding
ALE3EI_0730	COG0708	Exodeoxyribonuclease III
ALE3EI_0736	COG0423	glycine-tRNA ligase activity
ALE3EI_0738	COG1040	competence protein
ALE3EI_0740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALE3EI_0742	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ALE3EI_0743	COG0436	Aminotransferase
ALE3EI_0744	COG5002	protein histidine kinase activity
ALE3EI_0744	COG2198	Histidine kinase
ALE3EI_0744	COG0784	Response regulator, receiver
ALE3EI_0746	COG1053	succinate dehydrogenase
ALE3EI_0749	COG0006	proline dipeptidase activity
ALE3EI_0750	COG1114	Component of the transport system for branched-chain amino acids
ALE3EI_0754	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ALE3EI_0760	COG1858	cytochrome C peroxidase
ALE3EI_0761	COG0316	Belongs to the HesB IscA family
ALE3EI_0762	COG0719	Fe-S assembly protein
ALE3EI_0764	COG0396	ATPase activity
ALE3EI_0765	COG0719	Fe-S assembly protein
ALE3EI_0766	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALE3EI_0768	COG2166	iron-sulfur cluster assembly
ALE3EI_0769	COG2151	metal-sulfur cluster biosynthetic enzyme
ALE3EI_0773	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ALE3EI_0783	COG4251	negative regulation of phosphorylation
ALE3EI_0786	COG4771	TonB-dependent receptor
ALE3EI_0788	COG3483	tryptophan 2,3-dioxygenase activity
ALE3EI_0790	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ALE3EI_0791	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ALE3EI_0792	COG1752	Esterase of the alpha-beta hydrolase superfamily
ALE3EI_0793	COG0322	excinuclease ABC activity
ALE3EI_0794	COG0189	ligase activity
ALE3EI_0796	COG0189	ligase activity
ALE3EI_0798	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ALE3EI_0801	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ALE3EI_0804	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ALE3EI_0809	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ALE3EI_0810	COG3590	peptidase
ALE3EI_0814	COG0750	zinc metalloprotease
ALE3EI_0815	COG1999	signal sequence binding
ALE3EI_0820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALE3EI_0821	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALE3EI_0822	COG1121	(ABC) transporter
ALE3EI_0823	COG0803	Belongs to the bacterial solute-binding protein 9 family
ALE3EI_0825	COG1321	iron dependent repressor
ALE3EI_0825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALE3EI_0830	COG0535	radical SAM domain protein
ALE3EI_0831	COG1024	Enoyl-CoA hydratase
ALE3EI_0832	COG5000	phosphorelay sensor kinase activity
ALE3EI_0833	COG1981	membrane
ALE3EI_0836	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALE3EI_0838	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ALE3EI_0839	COG0181	hydroxymethylbilane synthase activity
ALE3EI_0841	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ALE3EI_0844	COG0408	coproporphyrinogen oxidase activity
ALE3EI_0845	COG0113	porphobilinogen synthase activity
ALE3EI_0847	COG1253	flavin adenine dinucleotide binding
ALE3EI_0850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALE3EI_0855	COG4172	Belongs to the ABC transporter superfamily
ALE3EI_0857	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ALE3EI_0858	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ALE3EI_0860	COG1774	PSP1 C-terminal conserved region
ALE3EI_0861	COG1054	Belongs to the UPF0176 family
ALE3EI_0862	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ALE3EI_0867	COG0758	DNA mediated transformation
ALE3EI_0867	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ALE3EI_0874	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ALE3EI_0876	COG0756	dUTP diphosphatase activity
ALE3EI_0879	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ALE3EI_0880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ALE3EI_0881	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALE3EI_0882	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ALE3EI_0883	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALE3EI_0884	COG0356	it plays a direct role in the translocation of protons across the membrane
ALE3EI_0894	COG0151	Belongs to the GarS family
ALE3EI_0895	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ALE3EI_0896	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_0898	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALE3EI_0899	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ALE3EI_0900	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_0907	COG1091	dTDP-4-dehydrorhamnose reductase activity
ALE3EI_0908	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ALE3EI_0909	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ALE3EI_0913	COG4942	peptidase
ALE3EI_0914	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALE3EI_0916	COG1388	LysM domain
ALE3EI_0916	COG3584	3D domain protein
ALE3EI_0917	COG0126	phosphoglycerate kinase activity
ALE3EI_0920	COG0445	tRNA wobble uridine modification
ALE3EI_0921	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ALE3EI_0923	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALE3EI_0925	COG0330	HflC and HflK could
ALE3EI_0929	COG2194	sulfuric ester hydrolase activity
ALE3EI_0931	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALE3EI_0932	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ALE3EI_0934	COG0557	exoribonuclease II activity
ALE3EI_0936	COG0698	ribose 5-phosphate isomerase
ALE3EI_0938	COG2153	protein acetylation
ALE3EI_0941	COG0793	Belongs to the peptidase S41A family
ALE3EI_0942	COG0594	ribonuclease P activity
ALE3EI_0945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALE3EI_0948	COG0481	GTPase activity
ALE3EI_0951	COG4591	ABC-type transport system involved in lipoprotein release permease component
ALE3EI_0952	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ALE3EI_0953	COG0346	lactoylglutathione lyase activity
ALE3EI_0954	COG0307	riboflavin synthase, alpha
ALE3EI_0955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ALE3EI_0957	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ALE3EI_0958	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALE3EI_0959	COG0511	ligase activity, forming carbon-carbon bonds
ALE3EI_0960	COG0439	Biotin carboxylase
ALE3EI_0962	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALE3EI_0965	COG3842	ATPase activity
ALE3EI_0966	COG1505	serine-type exopeptidase activity
ALE3EI_0970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ALE3EI_0971	COG1970	mechanosensitive ion channel activity
ALE3EI_0972	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALE3EI_0973	COG1435	thymidine kinase activity
ALE3EI_0975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ALE3EI_0976	COG1573	uracil-dna glycosylase
ALE3EI_0978	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ALE3EI_0978	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ALE3EI_0979	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_0980	COG0720	synthase
ALE3EI_0987	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ALE3EI_0988	COG2885	chlorophyll binding
ALE3EI_0999	COG0328	RNA-DNA hybrid ribonuclease activity
ALE3EI_0999	COG3341	Caulimovirus viroplasmin
ALE3EI_1000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ALE3EI_1001	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALE3EI_1002	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALE3EI_1003	COG0571	ribonuclease III activity
ALE3EI_1005	COG0469	pyruvate kinase activity
ALE3EI_1007	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ALE3EI_1008	COG2954	triphosphatase activity
ALE3EI_1011	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ALE3EI_1012	COG3250	beta-galactosidase activity
ALE3EI_1013	COG4953	penicillin-binding protein 1C
ALE3EI_1015	COG2329	Antibiotic biosynthesis monooxygenase
ALE3EI_1016	COG1446	asparaginase
ALE3EI_1019	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_1021	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ALE3EI_1023	COG4260	virion core protein, lumpy skin disease virus
ALE3EI_1026	COG4221	oxidoreductase activity
ALE3EI_1029	COG0714	Associated with various cellular activities
ALE3EI_1032	COG2304	oxidoreductase activity
ALE3EI_1033	COG2304	oxidoreductase activity
ALE3EI_1039	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ALE3EI_1041	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ALE3EI_1043	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALE3EI_1044	COG0194	GDP metabolic process
ALE3EI_1045	COG1561	YicC-like family, N-terminal region
ALE3EI_1052	COG0626	cystathionine gamma-synthase activity
ALE3EI_1053	COG3275	phosphorelay sensor kinase activity
ALE3EI_1054	COG4566	intracellular signal transduction
ALE3EI_1059	COG1381	Involved in DNA repair and RecF pathway recombination
ALE3EI_1060	COG4771	TonB-dependent receptor
ALE3EI_1061	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALE3EI_1067	COG5507	3-demethylubiquinone-9 3-methyltransferase
ALE3EI_1069	COG1476	TRANSCRIPTIONal
ALE3EI_1071	COG0629	single-stranded DNA binding
ALE3EI_1072	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALE3EI_1072	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALE3EI_1074	COG1619	proteins homologs of microcin C7 resistance protein MccF
ALE3EI_1075	COG0792	nuclease activity
ALE3EI_1076	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALE3EI_1078	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALE3EI_1081	COG1201	RNA secondary structure unwinding
ALE3EI_1082	COG1793	dna ligase
ALE3EI_1085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ALE3EI_1087	COG0527	aspartate kinase activity
ALE3EI_1089	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALE3EI_1091	COG2207	Transcriptional regulator
ALE3EI_1094	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ALE3EI_1102	COG4191	Histidine kinase
ALE3EI_1102	COG0784	Response regulator, receiver
ALE3EI_1108	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ALE3EI_1113	COG0346	lactoylglutathione lyase activity
ALE3EI_1114	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALE3EI_1116	COG2239	Acts as a magnesium transporter
ALE3EI_1117	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALE3EI_1121	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALE3EI_1123	COG0196	riboflavin kinase activity
ALE3EI_1124	COG0193	aminoacyl-tRNA hydrolase activity
ALE3EI_1125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ALE3EI_1126	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALE3EI_1130	COG0793	Belongs to the peptidase S41A family
ALE3EI_1132	COG2095	MarC family integral membrane protein
ALE3EI_1144	COG0659	secondary active sulfate transmembrane transporter activity
ALE3EI_1147	COG4771	TonB-dependent receptor
ALE3EI_1149	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ALE3EI_1150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ALE3EI_1152	COG1278	Cold shock
ALE3EI_1155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ALE3EI_1156	COG4771	TonB-dependent receptor
ALE3EI_1161	COG1309	transcriptional regulator
ALE3EI_1169	COG0084	hydrolase, TatD family'
ALE3EI_1170	COG0252	asparaginase activity
ALE3EI_1172	COG0811	peptide transport
ALE3EI_1178	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ALE3EI_1179	COG0017	Asparaginyl-tRNA synthetase
ALE3EI_1182	COG0233	cytoplasmic translational termination
ALE3EI_1183	COG0528	UMP kinase activity
ALE3EI_1184	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ALE3EI_1185	COG0052	Belongs to the universal ribosomal protein uS2 family
ALE3EI_1186	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ALE3EI_1187	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ALE3EI_1190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALE3EI_1190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALE3EI_1193	COG3920	Histidine kinase
ALE3EI_1194	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ALE3EI_1194	COG2010	Cytochrome c
ALE3EI_1197	COG4242	Belongs to the peptidase S51 family
ALE3EI_1198	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALE3EI_1198	COG0189	ligase activity
ALE3EI_1200	COG3279	Response regulator of the LytR AlgR family
ALE3EI_1201	COG3920	Histidine kinase
ALE3EI_1203	COG1446	asparaginase
ALE3EI_1204	COG3537	Alpha-1,2-mannosidase
ALE3EI_1205	COG1408	metallophosphoesterase
ALE3EI_1206	COG3118	belongs to the thioredoxin family
ALE3EI_1215	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_1217	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_1222	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALE3EI_1223	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALE3EI_1225	COG0726	polysaccharide deacetylase
ALE3EI_1227	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_1228	COG0463	Glycosyl transferase, family 2
ALE3EI_1232	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ALE3EI_1234	COG0589	response to stress
ALE3EI_1235	COG0779	Required for maturation of 30S ribosomal subunits
ALE3EI_1236	COG0195	Participates in both transcription termination and antitermination
ALE3EI_1237	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ALE3EI_1240	COG0437	4 iron, 4 sulfur cluster binding
ALE3EI_1241	COG0052	Belongs to the universal ribosomal protein uS2 family
ALE3EI_1245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ALE3EI_1246	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ALE3EI_1247	COG0534	Mate efflux family protein
ALE3EI_1249	COG2255	four-way junction helicase activity
ALE3EI_1251	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ALE3EI_1252	COG0281	malic enzyme
ALE3EI_1252	COG0280	phosphate acetyltransferase
ALE3EI_1253	COG0632	four-way junction helicase activity
ALE3EI_1255	COG0509	glycine decarboxylation via glycine cleavage system
ALE3EI_1260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALE3EI_1261	COG0109	protoheme IX farnesyltransferase activity
ALE3EI_1262	COG1845	cytochrome c oxidase, subunit III
ALE3EI_1267	COG1999	signal sequence binding
ALE3EI_1268	COG2322	membrane
ALE3EI_1270	COG1136	(ABC) transporter
ALE3EI_1271	COG1136	(ABC) transporter
ALE3EI_1271	COG0577	efflux transmembrane transporter activity
ALE3EI_1272	COG0577	efflux transmembrane transporter activity
ALE3EI_1272	COG1136	(ABC) transporter
ALE3EI_1275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALE3EI_1276	COG1214	PFAM Peptidase M22, glycoprotease
ALE3EI_1281	COG0668	transmembrane transport
ALE3EI_1282	COG1331	Highly conserved protein containing a thioredoxin domain
ALE3EI_1288	COG3275	phosphorelay sensor kinase activity
ALE3EI_1289	COG3279	Response regulator of the LytR AlgR family
ALE3EI_1290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ALE3EI_1294	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALE3EI_1296	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ALE3EI_1298	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ALE3EI_1299	COG0596	Alpha beta hydrolase
ALE3EI_1303	COG0544	peptidyl-prolyl cis-trans isomerase activity
ALE3EI_1305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ALE3EI_1311	COG1428	Deoxynucleoside kinase
ALE3EI_1313	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ALE3EI_1314	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ALE3EI_1328	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALE3EI_1331	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ALE3EI_1333	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ALE3EI_1337	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ALE3EI_1338	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALE3EI_1341	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ALE3EI_1342	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ALE3EI_1344	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ALE3EI_1346	COG0022	dehydrogenase e1 component
ALE3EI_1346	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALE3EI_1347	COG4771	TonB-dependent receptor
ALE3EI_1348	COG0739	heme binding
ALE3EI_1350	COG3174	membrane
ALE3EI_1352	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALE3EI_1353	COG1428	Deoxynucleoside kinase
ALE3EI_1357	COG4206	TonB-dependent receptor
ALE3EI_1357	COG1629	transport
ALE3EI_1361	COG1309	transcriptional regulator
ALE3EI_1362	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ALE3EI_1363	COG3396	Phenylacetate-CoA oxygenase
ALE3EI_1364	COG3460	Phenylacetate-CoA oxygenase
ALE3EI_1365	COG3396	Phenylacetate-CoA oxygenase
ALE3EI_1366	COG2151	metal-sulfur cluster biosynthetic enzyme
ALE3EI_1368	COG1024	Enoyl-CoA hydratase
ALE3EI_1369	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALE3EI_1371	COG0183	Belongs to the thiolase family
ALE3EI_1373	COG2030	dehydratase
ALE3EI_1373	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_1376	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALE3EI_1377	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALE3EI_1378	COG0022	dehydrogenase e1 component
ALE3EI_1381	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ALE3EI_1389	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ALE3EI_1390	COG0791	NLP P60 protein
ALE3EI_1390	COG1388	LysM domain
ALE3EI_1391	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ALE3EI_1399	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ALE3EI_1401	COG2197	response regulator
ALE3EI_1403	COG0321	lipoyl(octanoyl) transferase activity
ALE3EI_1409	COG0745	RESPONSE REGULATOR receiver
ALE3EI_1409	COG3292	Two component regulator propeller
ALE3EI_1409	COG2205	protein histidine kinase activity
ALE3EI_1411	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ALE3EI_1419	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_1420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ALE3EI_1423	COG0811	peptide transport
ALE3EI_1424	COG0848	biopolymer transport protein
ALE3EI_1427	COG0285	dihydrofolate synthase activity
ALE3EI_1428	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ALE3EI_1429	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALE3EI_1433	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ALE3EI_1435	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_1440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ALE3EI_1441	COG1785	Belongs to the alkaline phosphatase family
ALE3EI_1442	COG1216	Glycosyl transferase, family 2
ALE3EI_1445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALE3EI_1445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALE3EI_1449	COG0339	signal peptide processing
ALE3EI_1450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ALE3EI_1451	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ALE3EI_1452	COG0563	adenylate kinase activity
ALE3EI_1453	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ALE3EI_1456	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALE3EI_1459	COG2003	Belongs to the UPF0758 family
ALE3EI_1465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALE3EI_1467	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALE3EI_1470	COG1629	transport
ALE3EI_1473	COG0049	tRNA binding
ALE3EI_1474	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ALE3EI_1475	COG0051	transcription antitermination factor activity, RNA binding
ALE3EI_1476	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ALE3EI_1477	COG0088	Forms part of the polypeptide exit tunnel
ALE3EI_1478	COG0089	rRNA binding
ALE3EI_1479	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ALE3EI_1480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ALE3EI_1481	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ALE3EI_1482	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ALE3EI_1483	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ALE3EI_1484	COG0255	Belongs to the universal ribosomal protein uL29 family
ALE3EI_1485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ALE3EI_1486	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ALE3EI_1487	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ALE3EI_1488	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ALE3EI_1489	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALE3EI_1490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ALE3EI_1491	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ALE3EI_1492	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ALE3EI_1493	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ALE3EI_1494	COG1841	ribosomal large subunit assembly
ALE3EI_1495	COG0200	Binds to the 23S rRNA
ALE3EI_1496	COG0201	protein transport
ALE3EI_1497	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ALE3EI_1498	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ALE3EI_1499	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ALE3EI_1500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ALE3EI_1501	COG0202	RNA polymerase activity
ALE3EI_1502	COG0203	ribosomal protein L17
ALE3EI_1503	COG0505	Belongs to the CarA family
ALE3EI_1504	COG0148	phosphopyruvate hydratase activity
ALE3EI_1509	COG1090	epimerase
ALE3EI_1511	COG0018	arginyl-trna synthetase
ALE3EI_1517	COG3851	Histidine kinase
ALE3EI_1534	COG0513	Belongs to the DEAD box helicase family
ALE3EI_1536	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ALE3EI_1537	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ALE3EI_1538	COG3339	Conserved Protein
ALE3EI_1547	COG0433	COG0433 Predicted ATPase
ALE3EI_1548	COG0251	oxidation-reduction process
ALE3EI_1549	COG0602	queuosine metabolic process
ALE3EI_1551	COG0187	DNA topoisomerase II activity
ALE3EI_1554	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALE3EI_1556	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ALE3EI_1557	COG0215	cysteine-tRNA ligase activity
ALE3EI_1558	COG0302	gtp cyclohydrolase
ALE3EI_1563	COG0442	prolyl-tRNA aminoacylation
ALE3EI_1564	COG0268	Binds directly to 16S ribosomal RNA
ALE3EI_1572	COG2095	MarC family integral membrane protein
ALE3EI_1574	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ALE3EI_1588	COG4447	cellulose binding
ALE3EI_1598	COG4680	protein conserved in bacteria
ALE3EI_1625	COG4974	Belongs to the 'phage' integrase family
ALE3EI_1626	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ALE3EI_1627	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALE3EI_1629	COG0564	pseudouridine synthase activity
ALE3EI_1630	COG3022	response to hydroperoxide
ALE3EI_1637	COG0159	tryptophan synthase activity
ALE3EI_1638	COG0133	tryptophan synthase activity
ALE3EI_1639	COG0135	phosphoribosylanthranilate isomerase activity
ALE3EI_1640	COG0134	indole-3-glycerol-phosphate synthase activity
ALE3EI_1641	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALE3EI_1642	COG0512	Glutamine amidotransferase of anthranilate synthase
ALE3EI_1643	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALE3EI_1647	COG1846	Transcriptional regulator
ALE3EI_1648	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_1650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALE3EI_1651	COG1054	Belongs to the UPF0176 family
ALE3EI_1658	COG4452	Inner membrane protein CreD
ALE3EI_1664	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ALE3EI_1665	COG1217	gtp-binding protein TYPA
ALE3EI_1676	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_1678	COG1216	Glycosyl transferase, family 2
ALE3EI_1678	COG0463	Glycosyl transferase, family 2
ALE3EI_1682	COG2884	Cell division ATP-binding protein ftsE
ALE3EI_1687	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ALE3EI_1694	COG3876	Protein conserved in bacteria
ALE3EI_1695	COG0577	efflux transmembrane transporter activity
ALE3EI_1700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALE3EI_1701	COG1115	amino acid carrier protein
ALE3EI_1703	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_1705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ALE3EI_1707	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ALE3EI_1708	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALE3EI_1709	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALE3EI_1711	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ALE3EI_1712	COG0081	regulation of translation
ALE3EI_1713	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ALE3EI_1714	COG0222	ribosome binding
ALE3EI_1715	COG0085	RNA polymerase activity
ALE3EI_1716	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ALE3EI_1720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ALE3EI_1724	COG2885	chlorophyll binding
ALE3EI_1725	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ALE3EI_1727	COG1482	cell wall glycoprotein biosynthetic process
ALE3EI_1736	COG0326	Molecular chaperone. Has ATPase activity
ALE3EI_1737	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_1737	COG1506	peptidase
ALE3EI_1738	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALE3EI_1741	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALE3EI_1743	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ALE3EI_1745	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALE3EI_1748	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALE3EI_1750	COG1546	Belongs to the CinA family
ALE3EI_1750	COG1058	Belongs to the CinA family
ALE3EI_1751	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ALE3EI_1752	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALE3EI_1754	COG0552	protein localization to endoplasmic reticulum
ALE3EI_1756	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALE3EI_1763	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ALE3EI_1764	COG0189	ligase activity
ALE3EI_1766	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALE3EI_1766	COG0519	Catalyzes the synthesis of GMP from XMP
ALE3EI_1770	COG3530	Putative quorum-sensing-regulated virulence factor
ALE3EI_1771	COG0504	CTP synthase activity
ALE3EI_1772	COG0706	membrane insertase activity
ALE3EI_1774	COG0482	sulfurtransferase activity
ALE3EI_1775	COG1404	Belongs to the peptidase S8 family
ALE3EI_1780	COG0019	diaminopimelate decarboxylase activity
ALE3EI_1781	COG0045	succinate-CoA ligase (ADP-forming) activity
ALE3EI_1785	COG0071	Belongs to the small heat shock protein (HSP20) family
ALE3EI_1786	COG1187	pseudouridine synthase activity
ALE3EI_1789	COG0556	nucleotide-excision repair
ALE3EI_1791	COG4106	trans-aconitate 2-methyltransferase activity
ALE3EI_1795	COG1131	(ABC) transporter
ALE3EI_1799	COG1612	heme a metabolic process
ALE3EI_1801	COG0617	tRNA 3'-terminal CCA addition
ALE3EI_1801	COG0517	IMP dehydrogenase activity
ALE3EI_1801	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ALE3EI_1802	COG0009	L-threonylcarbamoyladenylate synthase
ALE3EI_1805	COG0463	Glycosyl transferase, family 2
ALE3EI_1811	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_1812	COG2264	protein methyltransferase activity
ALE3EI_1815	COG2171	N-acyltransferase activity
ALE3EI_1816	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ALE3EI_1817	COG0242	peptide deformylase activity
ALE3EI_1819	COG3956	TIGRFAM MazG family protein
ALE3EI_1822	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ALE3EI_1826	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALE3EI_1828	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ALE3EI_1829	COG0735	belongs to the Fur family
ALE3EI_1830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALE3EI_1831	COG0501	Belongs to the peptidase M48B family
ALE3EI_1833	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALE3EI_1837	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALE3EI_1839	COG2195	Cleaves the N-terminal amino acid of tripeptides
ALE3EI_1840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALE3EI_1842	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ALE3EI_1843	COG0105	UTP biosynthetic process
ALE3EI_1846	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ALE3EI_1848	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ALE3EI_1850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ALE3EI_1856	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ALE3EI_1858	COG1475	DNA binding
ALE3EI_1859	COG1192	Involved in chromosome partitioning
ALE3EI_1861	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_1863	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_1863	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_1865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_1867	COG0572	uridine kinase
ALE3EI_1868	COG2010	Cytochrome c
ALE3EI_1869	COG2133	pyrroloquinoline quinone binding
ALE3EI_1872	COG3273	potassium ion transport
ALE3EI_1872	COG0471	metal ion transport
ALE3EI_1874	COG0492	ferredoxin-NADP+ reductase activity
ALE3EI_1887	COG0583	DNA-binding transcription factor activity
ALE3EI_1889	COG0714	Associated with various cellular activities
ALE3EI_1896	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALE3EI_1901	COG1252	NADH dehydrogenase
ALE3EI_1904	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ALE3EI_1909	COG3275	phosphorelay sensor kinase activity
ALE3EI_1912	COG3279	Response regulator of the LytR AlgR family
ALE3EI_1919	COG1595	DNA-templated transcription, initiation
ALE3EI_1928	COG1652	LysM domain
ALE3EI_1928	COG2823	Periplasmic or secreted lipoprotein
ALE3EI_1929	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ALE3EI_1930	COG1228	amidohydrolase
ALE3EI_1939	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_1940	COG0183	Belongs to the thiolase family
ALE3EI_1941	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALE3EI_1941	COG1024	Enoyl-CoA hydratase
ALE3EI_1943	COG1022	Amp-dependent synthetase and ligase
ALE3EI_1945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALE3EI_1945	COG0047	phosphoribosylformylglycinamidine synthase activity
ALE3EI_1948	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ALE3EI_1948	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALE3EI_1953	COG1132	(ABC) transporter
ALE3EI_1954	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALE3EI_1957	COG0254	rRNA binding
ALE3EI_1962	COG0747	negative chemotaxis
ALE3EI_1964	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALE3EI_1971	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ALE3EI_1972	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALE3EI_1976	COG1120	ATPase activity
ALE3EI_1977	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ALE3EI_1983	COG1595	DNA-templated transcription, initiation
ALE3EI_1990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ALE3EI_1994	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ALE3EI_1997	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_1999	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ALE3EI_2004	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ALE3EI_2005	COG3279	Response regulator of the LytR AlgR family
ALE3EI_2006	COG0360	Binds together with S18 to 16S ribosomal RNA
ALE3EI_2007	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ALE3EI_2008	COG0359	binds to the 23S rRNA
ALE3EI_2010	COG1136	(ABC) transporter
ALE3EI_2010	COG0577	efflux transmembrane transporter activity
ALE3EI_2011	COG0124	histidyl-tRNA synthetase
ALE3EI_2015	COG0569	domain protein
ALE3EI_2021	COG4585	Histidine kinase
ALE3EI_2024	COG1678	Uncharacterized ACR, COG1678
ALE3EI_2026	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALE3EI_2031	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALE3EI_2034	COG0415	Belongs to the DNA photolyase family
ALE3EI_2036	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALE3EI_2040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ALE3EI_2043	COG0424	maF-like protein
ALE3EI_2050	COG1333	cytochrome c biogenesis protein
ALE3EI_2050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALE3EI_2055	COG1393	Belongs to the ArsC family
ALE3EI_2057	COG0456	acetyltransferase
ALE3EI_2057	COG1846	Transcriptional regulator
ALE3EI_2058	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ALE3EI_2062	COG3422	double-strand break repair
ALE3EI_2063	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALE3EI_2066	COG0156	8-amino-7-oxononanoate synthase activity
ALE3EI_2067	COG0456	acetyltransferase
ALE3EI_2076	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALE3EI_2079	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ALE3EI_2080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALE3EI_2082	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ALE3EI_2087	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALE3EI_2089	COG4251	negative regulation of phosphorylation
ALE3EI_2090	COG2205	protein histidine kinase activity
ALE3EI_2092	COG1136	(ABC) transporter
ALE3EI_2094	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALE3EI_2095	COG0302	gtp cyclohydrolase
ALE3EI_2097	COG4771	TonB-dependent receptor
ALE3EI_2102	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALE3EI_2103	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ALE3EI_2105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALE3EI_2111	COG0012	GTP binding
ALE3EI_2117	COG2205	protein histidine kinase activity
ALE3EI_2117	COG0784	Response regulator, receiver
ALE3EI_2121	COG1522	sequence-specific DNA binding
ALE3EI_2122	COG0693	protein deglycase activity
ALE3EI_2124	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ALE3EI_2130	COG2169	Transcriptional regulator
ALE3EI_2130	COG1917	Cupin 2, conserved barrel domain protein
ALE3EI_2135	COG2255	four-way junction helicase activity
ALE3EI_2136	COG2204	response regulator
ALE3EI_2137	COG1078	dGTPase activity
ALE3EI_2138	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_2139	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_2139	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ALE3EI_2140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_2141	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALE3EI_2142	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_2144	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ALE3EI_2145	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_2148	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALE3EI_2149	COG0052	Belongs to the universal ribosomal protein uS2 family
ALE3EI_2151	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ALE3EI_2152	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ALE3EI_2153	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALE3EI_2154	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ALE3EI_2154	COG0131	Imidazoleglycerol-phosphate dehydratase
ALE3EI_2156	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ALE3EI_2157	COG0107	imidazoleglycerol-phosphate synthase activity
ALE3EI_2158	COG0140	phosphoribosyl-ATP diphosphatase activity
ALE3EI_2158	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALE3EI_2159	COG0598	Magnesium transport protein CorA
ALE3EI_2165	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_2169	COG0668	transmembrane transport
ALE3EI_2170	COG2814	Major facilitator Superfamily
ALE3EI_2171	COG3264	Mechanosensitive ion channel
ALE3EI_2171	COG1196	nuclear chromosome segregation
ALE3EI_2173	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_2179	COG1360	Flagellar Motor Protein
ALE3EI_2180	COG0668	transmembrane transport
ALE3EI_2181	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALE3EI_2194	COG1278	Cold shock
ALE3EI_2195	COG2169	Transcriptional regulator
ALE3EI_2201	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALE3EI_2208	COG2353	YceI-like domain
ALE3EI_2212	COG3590	peptidase
ALE3EI_2213	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_2220	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ALE3EI_2222	COG2814	Major facilitator Superfamily
ALE3EI_2227	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALE3EI_2228	COG0861	Integral membrane protein TerC family
ALE3EI_2229	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALE3EI_2231	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_2233	COG3424	synthase
ALE3EI_2235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALE3EI_2239	COG0022	dehydrogenase e1 component
ALE3EI_2242	COG0813	purine-nucleoside phosphorylase activity
ALE3EI_2245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALE3EI_2247	COG3011	Protein conserved in bacteria
ALE3EI_2250	COG0189	ligase activity
ALE3EI_2252	COG1301	dicarboxylic acid transport
ALE3EI_2253	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ALE3EI_2255	COG0247	lactate metabolic process
ALE3EI_2255	COG0277	FAD linked oxidase domain protein
ALE3EI_2259	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_2260	COG1472	Belongs to the glycosyl hydrolase 3 family
ALE3EI_2262	COG0247	lactate metabolic process
ALE3EI_2262	COG2181	nitrate reductase activity
ALE3EI_2264	COG0247	lactate metabolic process
ALE3EI_2264	COG2181	nitrate reductase activity
ALE3EI_2266	COG0860	N-Acetylmuramoyl-L-alanine amidase
ALE3EI_2268	COG0251	oxidation-reduction process
ALE3EI_2270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ALE3EI_2274	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALE3EI_2285	COG3685	Protein conserved in bacteria
ALE3EI_2286	COG3292	Two component regulator propeller
ALE3EI_2286	COG2205	protein histidine kinase activity
ALE3EI_2286	COG0745	RESPONSE REGULATOR receiver
ALE3EI_2289	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ALE3EI_2291	COG0183	Belongs to the thiolase family
ALE3EI_2292	COG0791	NLP P60 protein
ALE3EI_2293	COG0457	Tetratricopeptide repeat
ALE3EI_2293	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALE3EI_2295	COG0542	response to heat
ALE3EI_2299	COG2986	histidine ammonia-lyase
ALE3EI_2300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_2301	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ALE3EI_2301	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ALE3EI_2302	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ALE3EI_2304	COG2154	pterin-4-alpha-carbinolamine dehydratase
ALE3EI_2305	COG0793	Belongs to the peptidase S41A family
ALE3EI_2306	COG0217	transcriptional regulatory protein
ALE3EI_2309	COG1454	alcohol dehydrogenase
ALE3EI_2311	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALE3EI_2317	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALE3EI_2321	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALE3EI_2323	COG0259	pyridoxamine-phosphate oxidase activity
ALE3EI_2325	COG1234	tRNA 3'-trailer cleavage
ALE3EI_2327	COG0540	Belongs to the ATCase OTCase family
ALE3EI_2328	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ALE3EI_2333	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ALE3EI_2335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ALE3EI_2336	COG1595	DNA-templated transcription, initiation
ALE3EI_2341	COG2270	Major facilitator Superfamily
ALE3EI_2345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALE3EI_2346	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALE3EI_2347	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALE3EI_2348	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ALE3EI_2353	COG4974	Belongs to the 'phage' integrase family
ALE3EI_2354	COG0656	L-ascorbic acid biosynthetic process
ALE3EI_2355	COG1418	mRNA catabolic process
ALE3EI_2360	COG1104	cysteine desulfurase activity
ALE3EI_2366	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALE3EI_2367	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALE3EI_2370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALE3EI_2370	COG0116	Belongs to the methyltransferase superfamily
ALE3EI_2373	COG1272	protein, Hemolysin III
ALE3EI_2378	COG1363	Peptidase, m42
ALE3EI_2383	COG1115	amino acid carrier protein
ALE3EI_2385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ALE3EI_2386	COG1702	phosphate starvation-inducible protein PhoH
ALE3EI_2391	COG0592	DNA-directed DNA polymerase activity
ALE3EI_2392	COG0596	Alpha beta hydrolase
ALE3EI_2393	COG2205	protein histidine kinase activity
ALE3EI_2393	COG0784	Response regulator, receiver
ALE3EI_2397	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ALE3EI_2402	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ALE3EI_2404	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALE3EI_2406	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_2411	COG0367	asparagine synthase
ALE3EI_2412	COG0110	maltose O-acetyltransferase activity
ALE3EI_2413	COG2244	polysaccharide biosynthetic process
ALE3EI_2415	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_2418	COG2244	polysaccharide biosynthetic process
ALE3EI_2420	COG0175	sulfate reduction
ALE3EI_2421	COG0529	Catalyzes the synthesis of activated sulfate
ALE3EI_2425	COG0783	Belongs to the Dps family
ALE3EI_2432	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_2434	COG0705	Rhomboid family
ALE3EI_2436	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALE3EI_2438	COG0405	Gamma-glutamyltransferase
ALE3EI_2440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALE3EI_2441	COG1611	Belongs to the LOG family
ALE3EI_2444	COG0022	dehydrogenase e1 component
ALE3EI_2446	COG0367	asparagine synthase
ALE3EI_2448	COG2197	response regulator
ALE3EI_2453	COG2996	Protein conserved in bacteria
ALE3EI_2455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ALE3EI_2456	COG1169	isochorismate synthase
ALE3EI_2457	COG2050	protein possibly involved in aromatic compounds catabolism
ALE3EI_2460	COG0385	Bile acid
ALE3EI_2471	COG0443	Heat shock 70 kDa protein
ALE3EI_2472	COG0587	DNA-directed DNA polymerase activity
ALE3EI_2473	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ALE3EI_2474	COG2135	peptidase activity
ALE3EI_2475	COG1760	l-serine dehydratase
ALE3EI_2477	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ALE3EI_2478	COG0564	pseudouridine synthase activity
ALE3EI_2480	COG4585	Histidine kinase
ALE3EI_2485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ALE3EI_2487	COG1914	H( )-stimulated, divalent metal cation uptake system
ALE3EI_2488	COG0612	Peptidase, M16
ALE3EI_2489	COG0606	chelatase, subunit chli
ALE3EI_2490	COG2197	response regulator
ALE3EI_2491	COG4585	Histidine kinase
ALE3EI_2494	COG0166	Belongs to the GPI family
ALE3EI_2497	COG0205	6-phosphofructokinase activity
ALE3EI_2500	COG0037	tRNA processing
ALE3EI_2501	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALE3EI_2504	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALE3EI_2512	COG1757	Na H antiporter
ALE3EI_2513	COG0450	alkyl hydroperoxide reductase
ALE3EI_2514	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ALE3EI_2517	COG1674	ftsk spoiiie
ALE3EI_2520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALE3EI_2520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALE3EI_2523	COG3292	Two component regulator propeller
ALE3EI_2523	COG2205	protein histidine kinase activity
ALE3EI_2523	COG0745	RESPONSE REGULATOR receiver
ALE3EI_2524	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ALE3EI_2531	COG0589	response to stress
ALE3EI_2539	COG0589	response to stress
ALE3EI_2543	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ALE3EI_2551	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALE3EI_2552	COG0589	response to stress
ALE3EI_2554	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ALE3EI_2555	COG4263	nitrous-oxide reductase activity
ALE3EI_2560	COG1131	(ABC) transporter
ALE3EI_2569	COG2217	Heavy metal translocating P-type atpase
ALE3EI_2571	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALE3EI_2574	COG2132	Multicopper oxidase
ALE3EI_2578	COG0701	Predicted permease
ALE3EI_2579	COG2217	Heavy metal translocating P-type atpase
ALE3EI_2602	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ALE3EI_2603	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALE3EI_2607	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALE3EI_2607	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALE3EI_2610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ALE3EI_2611	COG0626	cystathionine gamma-synthase activity
ALE3EI_2612	COG1228	amidohydrolase
ALE3EI_2613	COG0010	Belongs to the arginase family
ALE3EI_2618	COG4771	TonB-dependent receptor
ALE3EI_2621	COG1506	peptidase
ALE3EI_2621	COG4946	Tricorn protease homolog
ALE3EI_2621	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_2623	COG0488	(ABC) transporter
ALE3EI_2625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ALE3EI_2629	COG1629	transport
ALE3EI_2632	COG4948	Mandelate Racemase Muconate Lactonizing
ALE3EI_2633	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ALE3EI_2634	COG1575	Belongs to the MenA family. Type 1 subfamily
ALE3EI_2643	COG0009	L-threonylcarbamoyladenylate synthase
ALE3EI_2646	COG1473	amidohydrolase
ALE3EI_2647	COG0069	glutamate synthase activity
ALE3EI_2648	COG3279	Response regulator of the LytR AlgR family
ALE3EI_2649	COG3275	phosphorelay sensor kinase activity
ALE3EI_2654	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ALE3EI_2661	COG0488	(ABC) transporter
ALE3EI_2663	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ALE3EI_2664	COG0300	oxidoreductase activity
ALE3EI_2667	COG1278	Cold shock
ALE3EI_2669	COG1858	cytochrome C peroxidase
ALE3EI_2672	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALE3EI_2676	COG0542	response to heat
ALE3EI_2684	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ALE3EI_2685	COG4771	TonB-dependent receptor
ALE3EI_2688	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ALE3EI_2689	COG0673	inositol 2-dehydrogenase activity
ALE3EI_2690	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALE3EI_2692	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ALE3EI_2694	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALE3EI_2695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ALE3EI_2698	COG0237	dephospho-CoA kinase activity
ALE3EI_2700	COG0463	Glycosyl transferase, family 2
ALE3EI_2703	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ALE3EI_2704	COG0497	DNA recombination
ALE3EI_2709	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALE3EI_2711	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ALE3EI_2712	COG1611	Belongs to the LOG family
ALE3EI_2713	COG2890	protein-(glutamine-N5) methyltransferase activity
ALE3EI_2715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALE3EI_2715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALE3EI_2716	COG0697	spore germination
ALE3EI_2717	COG1739	Uncharacterized protein family UPF0029