locus-tag class description A9CBEGH2_00040 ENOG4105CKK Glycosyl transferase, family 2 A9CBEGH2_00050 ENOG4105WH5 Teichoic acid glycosylation protein A9CBEGH2_00070 ENOG4105EY8 ABC transporter A9CBEGH2_00090 ENOG4107SJB teichoic acid biosynthesis A9CBEGH2_00100 ENOG4107QRS glycosyltransferase group 2 family protein A9CBEGH2_00110 ENOG4107RZX Teichoic acid biosynthesis protein A9CBEGH2_00180 ENOG4105DQ6 Transposase A9CBEGH2_00220 ENOG4108IUM Glycogen debranching enzyme A9CBEGH2_00230 ENOG4105EPR degv family A9CBEGH2_00240 ENOG4105EPR degv family A9CBEGH2_00280 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A9CBEGH2_00290 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) A9CBEGH2_00300 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) A9CBEGH2_00310 ENOG4105C3M thioredoxin reductase A9CBEGH2_00320 ENOG4105W4W Transcriptional regulator A9CBEGH2_00340 ENOG41066F8 ROK family A9CBEGH2_00360 ENOG4105EBR Carboxylesterase A9CBEGH2_00380 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A9CBEGH2_00400 ENOG4105KA0 thioesterase Superfamily protein A9CBEGH2_00440 ENOG4105WBV Transcriptional regulator A9CBEGH2_00450 ENOG4105F1A Pyruvate formate-lyase A9CBEGH2_00460 ENOG4105C6N Formate acetyltransferase A9CBEGH2_00470 ENOG4105II7 pyrroline-5-carboxylate reductase A9CBEGH2_00520 ENOG4105EKQ RNA-directed DNA polymerase A9CBEGH2_00550 ENOG4105D1H recombination factor protein RarA A9CBEGH2_00560 ENOG4108X4Q Hydrolase A9CBEGH2_00580 ENOG4105D44 asparaginase A9CBEGH2_00600 ENOG4108ZJ4 polysaccharide deacetylase A9CBEGH2_00610 ENOG4108REF Sporulation integral membrane protein ytvi A9CBEGH2_00630 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 A9CBEGH2_00680 ENOG4108Z03 MAF-like protein A9CBEGH2_00730 ENOG4105CZX twitching motility protein A9CBEGH2_00850 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A9CBEGH2_00920 ENOG4105KY8 Rubrerythrin A9CBEGH2_00940 ENOG4105CJQ hydrolase, family 31 A9CBEGH2_01010 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A9CBEGH2_01020 ENOG4105C5H ABC transporter A9CBEGH2_01060 ENOG4105CIZ coA-substrate-specific enzyme activase A9CBEGH2_01140 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A9CBEGH2_01150 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) A9CBEGH2_01160 ENOG4105M2Z protein tyrosine serine phosphatase A9CBEGH2_01170 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A9CBEGH2_01180 ENOG4108Q5F Tetr family transcriptional regulator A9CBEGH2_01210 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A9CBEGH2_01230 ENOG4105HDK L-asparaginase A9CBEGH2_01260 ENOG41067QW Transcriptional regulator A9CBEGH2_01270 ENOG4105C6K Malic enzyme A9CBEGH2_01280 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A9CBEGH2_01290 ENOG41090I5 UPF0735 ACT domain-containing protein A9CBEGH2_01320 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) A9CBEGH2_01400 ENOG4105DQ6 Transposase A9CBEGH2_01450 ENOG4105BZW Glycerate kinase A9CBEGH2_01470 ENOG4105C59 p-type ATPase A9CBEGH2_01490 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) A9CBEGH2_01500 ENOG410667J hydrolase A9CBEGH2_01510 ENOG4108Z66 YbaK ebsC protein A9CBEGH2_01520 ENOG410667J hydrolase A9CBEGH2_01530 ENOG4105K63 Thioredoxin A9CBEGH2_01550 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) A9CBEGH2_01610 ENOG4105DFS Conserved Protein A9CBEGH2_01640 ENOG4105VJV 50s ribosomal protein L35 A9CBEGH2_01650 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) A9CBEGH2_01680 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of A9CBEGH2_01690 ENOG4108YBP pseudouridine synthase A9CBEGH2_01700 ENOG4105MAX Superoxide reductase A9CBEGH2_01710 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A9CBEGH2_01740 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A9CBEGH2_01780 ENOG4105EWC Purine nucleoside phosphorylase A9CBEGH2_01790 ENOG4106BHR ftsk SpoIIIE family protein A9CBEGH2_01800 ENOG4106128 DNA-binding helix-turn-helix protein A9CBEGH2_01830 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) A9CBEGH2_01900 ENOG4105K4H Nlp p60 protein A9CBEGH2_01950 ENOG4105US7 Histidine kinase A9CBEGH2_02010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A9CBEGH2_02020 ENOG4105BZU Histidine kinase A9CBEGH2_02060 ENOG4105DA5 (ABC) transporter A9CBEGH2_02170 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) A9CBEGH2_02180 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) A9CBEGH2_02190 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A9CBEGH2_02200 ENOG4105CFG Acts as a chaperone (By similarity) A9CBEGH2_02210 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A9CBEGH2_02220 ENOG4105CI2 imidazolone-5-propionate hydrolase A9CBEGH2_02240 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate A9CBEGH2_02260 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A9CBEGH2_02300 ENOG4105CE1 Ferrous iron transport protein b A9CBEGH2_02310 ENOG4105CE1 Ferrous iron transport protein b A9CBEGH2_02340 ENOG41083MR nifu domain-containing protein A9CBEGH2_02470 ENOG4107QM2 Aldo Keto reductase A9CBEGH2_02480 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) A9CBEGH2_02500 ENOG4105D52 delta-aminolevulinic acid dehydratase A9CBEGH2_02510 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase A9CBEGH2_02520 ENOG4108Z73 Siroheme synthase A9CBEGH2_02530 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A9CBEGH2_02550 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A9CBEGH2_02600 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) A9CBEGH2_02630 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A9CBEGH2_02680 ENOG4105CJN penicillin-binding protein A9CBEGH2_02690 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A9CBEGH2_02700 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) A9CBEGH2_02710 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A9CBEGH2_02730 ENOG4105C31 Tryptophanyl-tRNA synthetase A9CBEGH2_02740 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) A9CBEGH2_02800 ENOG4105CI3 gtp-binding protein typa A9CBEGH2_02820 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A9CBEGH2_02840 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A9CBEGH2_02850 ENOG4105CPF Cell wall formation (By similarity) A9CBEGH2_02860 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A9CBEGH2_02880 ENOG4105DZ0 fad dependent oxidoreductase A9CBEGH2_02910 ENOG4106PMH Extracellular solute-binding protein family 3 A9CBEGH2_02920 ENOG4108HW4 amino acid AbC transporter A9CBEGH2_02970 ENOG4105BZF Glycosyl transferase (Group 1 A9CBEGH2_02980 ENOG4105EQI Metal Dependent Phosphohydrolase A9CBEGH2_03030 ENOG4105C34 Pseudouridine synthase A9CBEGH2_03060 ENOG4105DQ6 Transposase A9CBEGH2_03210 ENOG4105C6T cysteine synthase A9CBEGH2_03220 ENOG4105D7W serine acetyltransferase A9CBEGH2_03230 ENOG4106N3A copper homeostasis protein cutc A9CBEGH2_03410 ENOG4108IGT Dipeptidase A9CBEGH2_03450 ENOG4105MS2 ribosomal subunit Interface protein A9CBEGH2_03470 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A9CBEGH2_03490 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) A9CBEGH2_03520 ENOG41068WN A9CBEGH2_03540 ENOG41081YB ApbE family A9CBEGH2_03550 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) A9CBEGH2_03560 ENOG4105D6A Electron transport complex A9CBEGH2_03580 ENOG4105DZB Electron transport complex A9CBEGH2_03590 ENOG4105DGN Electron transport complex A9CBEGH2_03610 ENOG4108R3D Electron transport complex A9CBEGH2_03630 ENOG4107RWR Sodium hydrogen exchanger A9CBEGH2_03670 ENOG4107R37 Glutamate dehydrogenase A9CBEGH2_03710 ENOG4105DAP Nicotinate phosphoribosyltransferase A9CBEGH2_03750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A9CBEGH2_03760 ENOG4108UMI ABC transporter, permease A9CBEGH2_03770 ENOG4105D01 (LipO)protein A9CBEGH2_03790 ENOG4107RFY SbcCD D subunit A9CBEGH2_03800 ENOG4105EYH Exonuclease A9CBEGH2_03810 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A9CBEGH2_03870 ENOG4108WCX response regulator A9CBEGH2_03900 ENOG4105EPR degv family A9CBEGH2_03960 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) A9CBEGH2_03970 ENOG4107QMS site-determining protein A9CBEGH2_04010 ENOG4105C2M dna polymerase I A9CBEGH2_04020 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A9CBEGH2_04030 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A9CBEGH2_04060 ENOG4105CTQ phosphohexokinase A9CBEGH2_04090 ENOG4105C22 threonyL-tRNA synthetase A9CBEGH2_04120 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) A9CBEGH2_04150 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A9CBEGH2_04160 ENOG4108RWN rrna methyltransferase A9CBEGH2_04170 ENOG4105CHU acetyl-coa acetyltransferase A9CBEGH2_04180 ENOG4105C1G acyl-Coa dehydrogenase A9CBEGH2_04190 ENOG4105BZJ Electron transfer flavoprotein A9CBEGH2_04200 ENOG4105C10 Electron transfer flavoprotein A9CBEGH2_04210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A9CBEGH2_04220 ENOG4105E39 Enoyl-CoA hydratase A9CBEGH2_04230 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) A9CBEGH2_04250 ENOG4105DQ6 Transposase A9CBEGH2_04330 ENOG410853A UPF0154 protein A9CBEGH2_04340 ENOG4105BZ4 penicillin-binding protein A9CBEGH2_04350 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A9CBEGH2_04380 ENOG4105C7H Helicase, RecD TraA family A9CBEGH2_04410 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A9CBEGH2_04420 ENOG4105VBH UPF0297 protein A9CBEGH2_04430 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) A9CBEGH2_04440 ENOG4105VPH UPF0473 protein A9CBEGH2_04450 ENOG4105HHA aminodeoxychorismate lyase A9CBEGH2_04460 ENOG4105DBI uridine monophosphokinase A9CBEGH2_04470 ENOG4107YHV Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A9CBEGH2_04480 ENOG4105KQC Competence protein A9CBEGH2_04600 ENOG4107QUV Domain protein A9CBEGH2_04780 ENOG4108ES9 ParB domain protein nuclease A9CBEGH2_04790 ENOG4107V6I Cytosine-specific methyltransferase A9CBEGH2_04840 ENOG4105CAR Terminase, large subunit A9CBEGH2_04860 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A9CBEGH2_05000 ENOG4105XSJ toxin secretion phage lysis holin A9CBEGH2_05070 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A9CBEGH2_05080 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A9CBEGH2_05150 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A9CBEGH2_05160 ENOG4105TQK DNA polymerase iii, delta' subunit A9CBEGH2_05170 ENOG4105EJQ L-serine dehydratase A9CBEGH2_05190 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) A9CBEGH2_05200 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A9CBEGH2_05210 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) A9CBEGH2_05220 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A9CBEGH2_05230 ENOG4105SFS phosphoesterase RecJ domain protein A9CBEGH2_05240 ENOG4105C0B DNA polymerase III (alpha subunit) A9CBEGH2_05250 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A9CBEGH2_05260 ENOG4105X36 (ribosomal) protein A9CBEGH2_05270 ENOG4105K46 50S ribosomal protein l27 A9CBEGH2_05280 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A9CBEGH2_05290 ENOG4105CGK Exodeoxyribonuclease III A9CBEGH2_05300 ENOG4105J7I hydrolase A9CBEGH2_05310 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A9CBEGH2_05320 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) A9CBEGH2_05340 ENOG4108QG2 Membrane A9CBEGH2_05370 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A9CBEGH2_05380 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A9CBEGH2_05390 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A9CBEGH2_05400 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A9CBEGH2_05420 ENOG4105CDE UPF0348 protein A9CBEGH2_05430 ENOG4105KNH Nucleic acid-binding protein A9CBEGH2_05440 ENOG41067VY 50S ribosomal protein L32 A9CBEGH2_05450 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) A9CBEGH2_05460 ENOG4105CHV Transcription elongation factor NusA A9CBEGH2_05470 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination A9CBEGH2_05490 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) A9CBEGH2_05500 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A9CBEGH2_05520 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic A9CBEGH2_05530 ENOG4105C5H ABC transporter A9CBEGH2_05540 ENOG4105DQ6 Transposase A9CBEGH2_05590 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A9CBEGH2_05600 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A9CBEGH2_05640 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) A9CBEGH2_05660 ENOG4108YZ4 nudix hydrolase A9CBEGH2_05670 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A9CBEGH2_05680 ENOG41090VF Stage v sporulation protein ac A9CBEGH2_05690 ENOG4105CZ3 stage V sporulation protein ad A9CBEGH2_05740 ENOG4108UXE Protein tyrosine phosphatase A9CBEGH2_05820 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A9CBEGH2_05860 ENOG4105JVQ RNA Polymerase A9CBEGH2_05880 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) A9CBEGH2_05900 ENOG4105DZ1 carboxypeptidase A9CBEGH2_05910 ENOG4108JIC nucleoside recognition domain protein A9CBEGH2_05940 ENOG4105FE9 pseudouridine synthase A9CBEGH2_05950 ENOG4105CJ1 ABC, transporter A9CBEGH2_05990 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A9CBEGH2_06000 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A9CBEGH2_06010 ENOG4105VCC 30S ribosomal protein S21 A9CBEGH2_06020 ENOG4105E98 transcriptional regulator DeoR family A9CBEGH2_06030 ENOG4108VA3 3-hexulose-6-phosphate synthase A9CBEGH2_06040 ENOG41080HJ 6-phospho 3-hexuloisomerase A9CBEGH2_06090 ENOG4105C9A Phoh family A9CBEGH2_06100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A9CBEGH2_06110 ENOG4105BZU Histidine kinase A9CBEGH2_06140 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A9CBEGH2_06160 ENOG4105KG3 cytidine deaminase A9CBEGH2_06170 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A9CBEGH2_06180 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) A9CBEGH2_06200 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A9CBEGH2_06210 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A9CBEGH2_06230 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A9CBEGH2_06250 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) A9CBEGH2_06260 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) A9CBEGH2_06270 ENOG4107RF6 penicillin-binding protein A9CBEGH2_06280 ENOG4105WDJ 50S ribosomal protein L33 A9CBEGH2_06290 ENOG4105C5X domain protein A9CBEGH2_06320 ENOG4106855 Competence protein A9CBEGH2_06370 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A9CBEGH2_06390 ENOG4105CAT Cytidine monophosphate kinase A9CBEGH2_06400 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) A9CBEGH2_06410 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) A9CBEGH2_06420 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) A9CBEGH2_06430 ENOG4105K70 DNA-binding protein A9CBEGH2_06450 ENOG4105DQ6 Transposase A9CBEGH2_06480 ENOG4105EPR degv family A9CBEGH2_06510 ENOG4105C8V SAICAR synthetase A9CBEGH2_06520 ENOG4105C83 adenylosuccinate lyase A9CBEGH2_06550 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A9CBEGH2_06610 ENOG4105MZ9 stage II sporulation protein m A9CBEGH2_06620 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A9CBEGH2_06640 ENOG4105S1Z Stage IV sporulation protein B A9CBEGH2_06650 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A9CBEGH2_06660 ENOG4105DX0 Hemolysin A A9CBEGH2_06670 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A9CBEGH2_06690 ENOG410868T Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A9CBEGH2_06700 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A9CBEGH2_06710 ENOG4105M7K Involved in the transcription termination process (By similarity) A9CBEGH2_06750 ENOG4105CIG ABC transporter A9CBEGH2_06780 ENOG4105DEU major facilitator superfamily A9CBEGH2_06800 ENOG4105C19 ABC transporter A9CBEGH2_06810 ENOG4105EWM Histidine kinase A9CBEGH2_06820 ENOG4105CJZ response regulator A9CBEGH2_06860 ENOG4105DTN riboflavin biosynthesis protein ribF A9CBEGH2_06870 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A9CBEGH2_06880 ENOG4105EV9 Alpha Beta Hydrolase A9CBEGH2_06900 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) A9CBEGH2_06930 ENOG4105C9M aspartyl-trna synthetase A9CBEGH2_06940 ENOG4105CUT histidyl-tRNA synthetase A9CBEGH2_06970 ENOG4105CDY transcriptional regulatory protein A9CBEGH2_07050 ENOG4107SET aldo keto reductase A9CBEGH2_07060 ENOG4105C8T Leucyl-tRNA synthetase A9CBEGH2_07180 ENOG4105BZ8 glutamate synthase A9CBEGH2_07190 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein A9CBEGH2_07210 ENOG4108ERU trap dicarboxylate transporter subunit DctP A9CBEGH2_07220 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A9CBEGH2_07240 ENOG4105EMV Major Facilitator A9CBEGH2_07250 ENOG4105E2X shikimate dehydrogenase A9CBEGH2_07270 ENOG4105DDW LysR family Transcriptional regulator A9CBEGH2_07290 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase A9CBEGH2_07300 ENOG4105ETU transcriptional activator (TenA A9CBEGH2_07310 ENOG4105DWF phosphomethylpyrimidine kinase A9CBEGH2_07320 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 A9CBEGH2_07330 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A9CBEGH2_07340 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase A9CBEGH2_07370 ENOG4105CTS PTS system mannitol-specific A9CBEGH2_07380 ENOG4105E98 transcriptional regulator DeoR family A9CBEGH2_07390 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein A9CBEGH2_07400 ENOG4105DE4 1-phosphofructokinase A9CBEGH2_07440 ENOG4108IJ8 ABC transporter A9CBEGH2_07450 ENOG4108HQR Glycine betaine A9CBEGH2_07470 ENOG4105KVH Transcriptional regulator A9CBEGH2_07490 ENOG4105C19 ABC transporter A9CBEGH2_07500 ENOG4105EWM Histidine kinase A9CBEGH2_07510 ENOG4105CJZ response regulator A9CBEGH2_07570 ENOG4105E5D amino acid A9CBEGH2_07580 ENOG4105DFM M18 family aminopeptidase A9CBEGH2_07610 ENOG4105N5T Radical SAM Protein A9CBEGH2_07620 ENOG4108Z86 Glutamine amidotransferase A9CBEGH2_08030 ENOG4108TFU terminase (Small subunit) A9CBEGH2_08260 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) A9CBEGH2_08300 ENOG4105CAQ asparagine synthetase A9CBEGH2_08330 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A9CBEGH2_08360 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A9CBEGH2_08370 ENOG4105ETE Transcriptional regulator (LacI family A9CBEGH2_08400 ENOG4105DFU Cell wall formation (By similarity) A9CBEGH2_08430 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) A9CBEGH2_08440 ENOG4107QSE Dipeptidase A9CBEGH2_08460 ENOG41067QW Transcriptional regulator A9CBEGH2_08520 ENOG4108WQI RNA Polymerase A9CBEGH2_08550 ENOG41067QW Transcriptional regulator A9CBEGH2_08560 ENOG4105C5X domain protein A9CBEGH2_08570 ENOG4105DB7 PHP domain protein A9CBEGH2_08590 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) A9CBEGH2_08600 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) A9CBEGH2_08630 ENOG4107YDN peptide deformylase A9CBEGH2_08640 ENOG4105CSA Coproporphyrinogen iii oxidase A9CBEGH2_08650 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A9CBEGH2_08690 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) A9CBEGH2_08700 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) A9CBEGH2_08720 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A9CBEGH2_08730 ENOG4105KNE Phosphatidate cytidylyltransferase A9CBEGH2_08740 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A9CBEGH2_08750 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A9CBEGH2_08760 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A9CBEGH2_08770 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) A9CBEGH2_08780 ENOG4105CE9 30S ribosomal protein S2 A9CBEGH2_08790 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A9CBEGH2_08800 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) A9CBEGH2_08810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A9CBEGH2_08820 ENOG4105C79 DNA protecting protein DprA A9CBEGH2_08880 ENOG4105C3F Signal peptidase i A9CBEGH2_08900 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) A9CBEGH2_08910 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A9CBEGH2_08920 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) A9CBEGH2_08940 ENOG4105K5M 30s ribosomal protein S16 A9CBEGH2_08980 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) A9CBEGH2_09000 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) A9CBEGH2_09010 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) A9CBEGH2_09040 ENOG4105C1V Peptidase, M16 A9CBEGH2_09060 ENOG4105UIB (ABC) transporter A9CBEGH2_09070 ENOG4108JQ9 ABC transporter A9CBEGH2_09080 ENOG4107TFB basic membrane A9CBEGH2_09090 ENOG41076CZ activating enzyme A9CBEGH2_09100 ENOG4105G0K glycine radical enzyme YjjI family A9CBEGH2_09110 ENOG4105CNU cell division protein FtsK A9CBEGH2_09130 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A9CBEGH2_09150 ENOG4105D48 metallophosphoesterase A9CBEGH2_09180 ENOG4105CEV competence damage-inducible protein A9CBEGH2_09190 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A9CBEGH2_09210 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) A9CBEGH2_09230 ENOG4105BZ4 penicillin-binding protein A9CBEGH2_09240 ENOG4105CSM endonuclease III A9CBEGH2_09270 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) A9CBEGH2_09280 ENOG4108D32 Methyltransferase A9CBEGH2_09300 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) A9CBEGH2_09320 ENOG4105CQW ribosome biogenesis GTPase YqeH A9CBEGH2_09330 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase A9CBEGH2_09340 ENOG4105DER m42 family A9CBEGH2_09350 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A9CBEGH2_09410 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A9CBEGH2_09420 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) A9CBEGH2_09430 ENOG41082AN stage II sporulation protein A9CBEGH2_09450 ENOG4105DZ1 carboxypeptidase A9CBEGH2_09590 ENOG4108UNV SUF system FeS assembly protein, NifU family A9CBEGH2_09600 ENOG4105C9B Cysteine desulfurase A9CBEGH2_09610 ENOG4105JRK feS assembly protein SufD A9CBEGH2_09620 ENOG4105C3K feS assembly ATPase SufC A9CBEGH2_09630 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A9CBEGH2_09670 ENOG4106H78 methyltransferase A9CBEGH2_09680 ENOG4105CNI cell division protein FtsW A9CBEGH2_09690 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A9CBEGH2_09710 ENOG4105DIN metallophosphoesterase A9CBEGH2_09730 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A9CBEGH2_09740 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) A9CBEGH2_09760 ENOG4105CE1 Ferrous iron transport protein b A9CBEGH2_09840 ENOG4108WS4 fmn reductase A9CBEGH2_09880 ENOG4105BZU Histidine kinase A9CBEGH2_09890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A9CBEGH2_09910 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A9CBEGH2_09960 ENOG4105NAE bifunctional deaminase-reductase domain protein A9CBEGH2_10000 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_10010 ENOG4105C5Y PTS System A9CBEGH2_10080 ENOG4105CEM UPF0597 protein A9CBEGH2_10090 ENOG4107AYK membrAne A9CBEGH2_10100 ENOG4105CAQ asparagine synthetase A9CBEGH2_10130 ENOG4105KME endoribonuclease L-psp A9CBEGH2_10170 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A9CBEGH2_10180 ENOG4105D4P Coproporphyrinogen iii oxidase A9CBEGH2_10240 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A9CBEGH2_10280 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A9CBEGH2_10360 ENOG4108VXD carboxy-peptidase A9CBEGH2_10380 ENOG4105PFC Transcriptional regulator A9CBEGH2_10390 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A9CBEGH2_10420 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A9CBEGH2_10440 ENOG4107YWA deoxycytidylate deaminase A9CBEGH2_10460 ENOG4105C34 Pseudouridine synthase A9CBEGH2_10470 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A9CBEGH2_10500 ENOG4108UW5 maltose o-acetyltransferase A9CBEGH2_10530 ENOG4105DQ6 Transposase A9CBEGH2_10540 ENOG4105VUF Transcriptional regulator A9CBEGH2_10570 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A9CBEGH2_10620 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A9CBEGH2_10640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A9CBEGH2_10660 ENOG4107RWR Sodium hydrogen exchanger A9CBEGH2_10670 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A9CBEGH2_10710 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain A9CBEGH2_10720 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A9CBEGH2_10730 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A9CBEGH2_10750 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) A9CBEGH2_10760 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) A9CBEGH2_10770 ENOG4105CD3 dihydroorotase A9CBEGH2_10780 ENOG4105CXT aspartate transcarbamylase A9CBEGH2_10840 ENOG4107VMI polysaccharide deacetylase A9CBEGH2_10870 ENOG4105DP4 dak2 domain fusion protein ylov A9CBEGH2_10880 ENOG4108ZAA Alkaline-shock protein A9CBEGH2_10900 ENOG4105D4A Cell wall formation (By similarity) A9CBEGH2_10920 ENOG4105CNI cell division protein FtsW A9CBEGH2_10930 ENOG4105KFN sortase, SrtB family A9CBEGH2_10940 ENOG41082BM Transcriptional regulator, arsr family A9CBEGH2_10960 ENOG4105CJ1 ABC, transporter A9CBEGH2_11020 ENOG4105BZ1 (ABC) transporter A9CBEGH2_11060 ENOG4105F1A Pyruvate formate-lyase A9CBEGH2_11070 ENOG4105C6N Formate acetyltransferase A9CBEGH2_11080 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) A9CBEGH2_11090 ENOG4105E98 transcriptional regulator DeoR family A9CBEGH2_11110 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A9CBEGH2_11150 ENOG4105DA5 (ABC) transporter A9CBEGH2_11160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A9CBEGH2_11210 ENOG4105CHR reductase A9CBEGH2_11230 ENOG4105C0A alcohol dehydrogenase A9CBEGH2_11240 ENOG4105C26 Dehydrogenase A9CBEGH2_11250 ENOG4105C26 Dehydrogenase A9CBEGH2_11320 ENOG4105CB5 ATP-dependent DNA helicase recG A9CBEGH2_11330 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A9CBEGH2_11360 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A9CBEGH2_11370 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A9CBEGH2_11390 ENOG4105IEH endo-beta-N-acetylglucosaminidase A9CBEGH2_11400 ENOG4105VB9 50S ribosomal protein l28 A9CBEGH2_11440 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A9CBEGH2_11450 ENOG4105D9P serine threonine protein kinase A9CBEGH2_11460 ENOG4108ZF3 Phosphatase A9CBEGH2_11470 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A9CBEGH2_11480 ENOG4105D1U peptidase U62 modulator of DNA gyrase A9CBEGH2_11490 ENOG4105D1U peptidase U62 modulator of DNA gyrase A9CBEGH2_11520 ENOG4105D29 Helix-turn-helix type 11 domain protein A9CBEGH2_11580 ENOG4105DIN metallophosphoesterase A9CBEGH2_11590 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A9CBEGH2_11610 ENOG4105C25 Primosomal protein n' A9CBEGH2_11680 ENOG4108HM4 ABC transporter A9CBEGH2_11690 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A9CBEGH2_11700 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase A9CBEGH2_11740 ENOG4105CZN Potassium uptake protein A9CBEGH2_11750 ENOG4108RAC Rubrerythrin A9CBEGH2_11770 ENOG4105EAM Na Pi-cotransporter A9CBEGH2_11780 ENOG4105C02 permease A9CBEGH2_11800 ENOG4105WZW rhodanese family A9CBEGH2_11820 ENOG4107ZE5 PPIases accelerate the folding of proteins A9CBEGH2_11870 ENOG4105HFZ Membrane A9CBEGH2_11890 ENOG4105C7B Threonine dehydratase A9CBEGH2_11940 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A9CBEGH2_11950 ENOG4105CFP Peptidase U32 A9CBEGH2_11980 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A9CBEGH2_11990 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) A9CBEGH2_12090 ENOG4105C1J atp-dependent rna helicase A9CBEGH2_12110 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A9CBEGH2_12120 ENOG4105C7W Xanthine dehydrogenase A9CBEGH2_12190 ENOG4105CJN penicillin-binding protein A9CBEGH2_12210 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A9CBEGH2_12220 ENOG4108V6E Cell division protein mraZ A9CBEGH2_12250 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A9CBEGH2_12280 ENOG4105WD1 Membrane A9CBEGH2_12300 ENOG4105BZ1 (ABC) transporter A9CBEGH2_12310 ENOG4108JJ9 ABC, transporter A9CBEGH2_12320 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase A9CBEGH2_12330 ENOG4105JRK feS assembly protein SufD A9CBEGH2_12340 ENOG4108IJ6 ABC transporter A9CBEGH2_12410 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_12420 ENOG4105C5Y PTS System A9CBEGH2_12430 ENOG4105CID antiterminator A9CBEGH2_12450 ENOG4108HHA Transketolase A9CBEGH2_12490 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A9CBEGH2_12510 ENOG4105DB7 PHP domain protein A9CBEGH2_12520 ENOG4105DQ6 Transposase A9CBEGH2_12600 ENOG4107ZS6 Flavodoxin A9CBEGH2_12610 ENOG4105DE4 1-phosphofructokinase A9CBEGH2_12620 ENOG410667J hydrolase A9CBEGH2_12630 ENOG4105DG6 mannose-6-phosphate isomerase A9CBEGH2_12640 ENOG4108X4Q Hydrolase A9CBEGH2_12750 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) A9CBEGH2_12790 ENOG4105DG6 mannose-6-phosphate isomerase A9CBEGH2_12830 ENOG4105F3R pts system mannose fructose sorbose family iid A9CBEGH2_12850 ENOG4105DAS pts system A9CBEGH2_12890 ENOG4105DC7 peptidase M24 A9CBEGH2_12910 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A9CBEGH2_12940 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A9CBEGH2_13000 ENOG4105C0H protease A9CBEGH2_13050 ENOG4108IUX (ABC) transporter A9CBEGH2_13070 ENOG4105DVE abc transporter atp-binding protein A9CBEGH2_13120 ENOG4105F1A Pyruvate formate-lyase A9CBEGH2_13130 ENOG4105C6N Formate acetyltransferase A9CBEGH2_13150 ENOG4105C37 (CBS) domain A9CBEGH2_13160 ENOG410667J hydrolase A9CBEGH2_13280 ENOG4107RSM transcriptional regulator A9CBEGH2_13300 ENOG4105E6M Sulphatase-modifying factor protein A9CBEGH2_13320 ENOG4105CPC Aldo Keto reductase A9CBEGH2_13330 ENOG4105CPC Aldo Keto reductase A9CBEGH2_13340 ENOG4105CPC Aldo Keto reductase A9CBEGH2_13370 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A9CBEGH2_13380 ENOG4107U9T Pfam:Ribonuclease_BN A9CBEGH2_13460 ENOG4105CE4 GlcNAc 6-P deacetylase A9CBEGH2_13470 ENOG4105CNW domain protein A9CBEGH2_13480 ENOG4105DIN metallophosphoesterase A9CBEGH2_13510 ENOG4108115 UPF0145 protein A9CBEGH2_13530 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) A9CBEGH2_13540 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A9CBEGH2_13560 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) A9CBEGH2_13570 ENOG4105C1A potassium transporter peripheral membrane A9CBEGH2_13600 ENOG4105EEX Two component transcriptional regulator (Winged helix family A9CBEGH2_13610 ENOG4105C08 Histidine kinase A9CBEGH2_13630 ENOG4105C08 Histidine kinase A9CBEGH2_13640 ENOG4105C08 Histidine kinase A9CBEGH2_13660 ENOG4105CIG ABC transporter A9CBEGH2_13670 ENOG4108IG5 Transcriptional regulator A9CBEGH2_13680 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) A9CBEGH2_13690 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A9CBEGH2_13700 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A9CBEGH2_13720 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A9CBEGH2_13790 ENOG4105CG3 alpha amylase, catalytic region A9CBEGH2_13800 ENOG4105C5Y PTS System A9CBEGH2_13810 ENOG4107414 GntR family transcriptional regulator A9CBEGH2_13830 ENOG41090A1 ferritin A9CBEGH2_13840 ENOG4105CXI aluminum resistance protein A9CBEGH2_13850 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A9CBEGH2_13860 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A9CBEGH2_13940 ENOG4105Y2Z radical SAM domain protein A9CBEGH2_13950 ENOG4106KKU A9CBEGH2_13960 ENOG4108Z15 abc transporter atp-binding protein A9CBEGH2_14040 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) A9CBEGH2_14060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A9CBEGH2_14080 ENOG4105CHM Aminotransferase A9CBEGH2_14130 ENOG4105C9Q fumarate hydratase class II A9CBEGH2_14150 ENOG4105KXX peptidase s58 dmpa A9CBEGH2_14220 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase A9CBEGH2_14240 ENOG4108JQ7 (ABC) transporter A9CBEGH2_14250 ENOG4105C3U ABC transporter A9CBEGH2_14260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A9CBEGH2_14280 ENOG4105DEF Extracellular solute-binding protein, family 5 A9CBEGH2_14290 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) A9CBEGH2_14320 ENOG4105C5H ABC transporter A9CBEGH2_14350 ENOG4105C5S asparaginyl-tRNA synthetase A9CBEGH2_14360 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) A9CBEGH2_14400 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) A9CBEGH2_14410 ENOG4105E98 transcriptional regulator DeoR family A9CBEGH2_14420 ENOG4105CN9 Peptidase m42 family protein A9CBEGH2_14460 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) A9CBEGH2_14490 ENOG4105F8C transglutaminase domain-containing protein A9CBEGH2_14510 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A9CBEGH2_14530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A9CBEGH2_14540 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) A9CBEGH2_14550 ENOG4108JJB ABC transporter A9CBEGH2_14640 ENOG4105CG9 aspartate racemase A9CBEGH2_14670 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A9CBEGH2_14700 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) A9CBEGH2_14710 ENOG4105D4U had-superfamily hydrolase, subfamily iia A9CBEGH2_14730 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A9CBEGH2_14750 ENOG4105WDJ 50S ribosomal protein L33 A9CBEGH2_14770 ENOG4105C2N RNA methyltransferase TrmH family group 3 A9CBEGH2_14780 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) A9CBEGH2_14790 ENOG4105C8N cysteinyl-tRNA synthetase A9CBEGH2_14820 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A9CBEGH2_14860 ENOG4105F3R pts system mannose fructose sorbose family iid A9CBEGH2_14870 ENOG4105ETZ PTS System A9CBEGH2_14880 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB A9CBEGH2_14900 ENOG4105DAS pts system A9CBEGH2_14910 ENOG4105E70 isomerase A9CBEGH2_14960 ENOG4105CIE May be required for sporulation (By similarity) A9CBEGH2_14970 ENOG4105CHW UPF0052 protein A9CBEGH2_14980 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A9CBEGH2_14990 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A9CBEGH2_15000 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) A9CBEGH2_15010 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) A9CBEGH2_15020 ENOG4105E4P ATPase (AAA A9CBEGH2_15060 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) A9CBEGH2_15100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A9CBEGH2_15140 ENOG4105E0C molybdate abc transporter A9CBEGH2_15150 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A9CBEGH2_15160 ENOG4108RIR Molybdenum cofactor biosynthesis protein A9CBEGH2_15200 ENOG4105CEV competence damage-inducible protein A9CBEGH2_15210 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family A9CBEGH2_15240 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family A9CBEGH2_15260 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) A9CBEGH2_15280 ENOG4108VXD carboxy-peptidase A9CBEGH2_15300 ENOG4107UVV polysaccharide deacetylase A9CBEGH2_15330 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) A9CBEGH2_15360 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) A9CBEGH2_15380 ENOG4105CDU Replicative dna helicase A9CBEGH2_15390 ENOG41082B8 Binds to the 23S rRNA (By similarity) A9CBEGH2_15400 ENOG4105BZR domain protein A9CBEGH2_15420 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A9CBEGH2_15430 ENOG4108UUM single-stranded DNA-binding protein A9CBEGH2_15440 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) A9CBEGH2_15450 ENOG4105C0D helicase A9CBEGH2_15510 ENOG4107RSM transcriptional regulator A9CBEGH2_15530 ENOG4108UQV Membrane A9CBEGH2_15540 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) A9CBEGH2_15640 ENOG4105ECB domain protein A9CBEGH2_15650 ENOG41062ES Transcriptional regulator A9CBEGH2_15660 ENOG410667J hydrolase A9CBEGH2_15670 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_15680 ENOG4107QK4 glycoside hydrolase, family 3 domain protein A9CBEGH2_15690 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_15700 ENOG4105F8D glycoside hydrolase family 4 A9CBEGH2_15710 ENOG4105CK1 PTS System A9CBEGH2_15720 ENOG4105VZJ PTS System A9CBEGH2_15730 ENOG4105VCP PTS System A9CBEGH2_15750 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A9CBEGH2_15760 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_15770 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_15780 ENOG4105CVJ phosphoglycerate mutase A9CBEGH2_15800 ENOG4105C5Y PTS System A9CBEGH2_15810 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) A9CBEGH2_15820 ENOG4105DQF Hydrolase A9CBEGH2_15850 ENOG4105CID antiterminator A9CBEGH2_15860 ENOG4105DQF Hydrolase A9CBEGH2_15870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A9CBEGH2_15880 ENOG4105E2R ROK family A9CBEGH2_15900 ENOG4105VCP PTS System A9CBEGH2_15920 ENOG4105CK1 PTS System A9CBEGH2_15930 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_15940 ENOG4108TZY GntR Family Transcriptional Regulator A9CBEGH2_16020 ENOG4105WH1 Two component transcriptional regulator luxr family A9CBEGH2_16030 ENOG4105BZU Histidine kinase A9CBEGH2_16040 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A9CBEGH2_16070 ENOG4105DFM M18 family aminopeptidase A9CBEGH2_16080 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A9CBEGH2_16140 ENOG4105CE1 Ferrous iron transport protein b A9CBEGH2_16160 ENOG4107R73 Mate efflux family protein A9CBEGH2_16170 ENOG4108U05 Transcriptional regulator A9CBEGH2_16210 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) A9CBEGH2_16220 ENOG4105CPN adenine deaminase A9CBEGH2_16240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A9CBEGH2_16250 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component A9CBEGH2_16260 ENOG4105F38 ABC transporter, permease A9CBEGH2_16280 ENOG4105CFP Peptidase U32 A9CBEGH2_16300 ENOG4105DWK Membrane A9CBEGH2_16340 ENOG4105F3H Histidine kinase A9CBEGH2_16360 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) A9CBEGH2_16410 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A9CBEGH2_16430 ENOG41072GX Peptidase M22 Glycoprotease A9CBEGH2_16440 ENOG4105K8N protein family UPF0079, ATPase A9CBEGH2_16450 ENOG4105EVI UPF0374 protein A9CBEGH2_16490 ENOG4108AQF aminoglycoside N(3)-acetyltransferase A9CBEGH2_16520 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein A9CBEGH2_16570 ENOG4105CEN a g-specific adenine glycosylase A9CBEGH2_16580 ENOG4105C0A alcohol dehydrogenase A9CBEGH2_16600 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A9CBEGH2_16610 ENOG4105F1A Pyruvate formate-lyase A9CBEGH2_16640 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) A9CBEGH2_16650 ENOG4107RAQ aminopeptidase A9CBEGH2_16680 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A9CBEGH2_16780 ENOG4108UTW Plays a role in the regulation of phosphate uptake A9CBEGH2_16800 ENOG4105E2Z phosphate ABC transporter (Permease A9CBEGH2_16820 ENOG4107S17 Phosphate-binding protein A9CBEGH2_16850 ENOG4108YZG isomerase A9CBEGH2_16870 ENOG4108HW3 (ABC) transporter A9CBEGH2_16880 ENOG4105CDA abc transporter atp-binding protein A9CBEGH2_16890 ENOG4105E5Q amino acid AbC transporter A9CBEGH2_16900 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A9CBEGH2_16920 ENOG41080E8 Transcriptional regulator, Spx MgsR family A9CBEGH2_16940 ENOG4105F8V Hydrolase, tatD family A9CBEGH2_16950 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A9CBEGH2_16960 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A9CBEGH2_16970 ENOG4108UGV hypoxanthine phosphoribosyltransferase A9CBEGH2_16980 ENOG4107XRM Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A9CBEGH2_17000 ENOG4105UQX Mate efflux family protein A9CBEGH2_17030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A9CBEGH2_17040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A9CBEGH2_17060 ENOG4108JQ7 (ABC) transporter A9CBEGH2_17080 ENOG4105DCI Phosphohydrolase A9CBEGH2_17090 ENOG4105M6F mutator MutT protein A9CBEGH2_17100 ENOG4105EE0 oxidoreductase A9CBEGH2_17120 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) A9CBEGH2_17140 ENOG4105C8J )-transporter A9CBEGH2_17150 ENOG4107QJT sodium dicarboxylate symporter A9CBEGH2_17180 ENOG4105FA0 parb-like partition protein A9CBEGH2_17190 ENOG4107QJE Chromosome Partitioning Protein A9CBEGH2_17200 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) A9CBEGH2_17210 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) A9CBEGH2_17280 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation A9CBEGH2_17310 ENOG4108ME1 Peptidase M55 D-aminopeptidase A9CBEGH2_17330 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A9CBEGH2_17340 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A9CBEGH2_17360 ENOG4107104 thymidine kinase A9CBEGH2_17370 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A9CBEGH2_17380 ENOG4105VFB Binds the 23S rRNA (By similarity) A9CBEGH2_17450 ENOG4105CT4 transporter A9CBEGH2_17480 ENOG4108DWA Nad synthetase A9CBEGH2_17490 ENOG4107QJQ Mate efflux family protein A9CBEGH2_17520 ENOG4105CE4 GlcNAc 6-P deacetylase A9CBEGH2_17540 ENOG4105X0R protein from nitrogen regulatory protein P-II A9CBEGH2_17550 ENOG4108NRW Phospholipase, patatin family A9CBEGH2_17570 ENOG4105ESV Glycosyl transferase, family 4 A9CBEGH2_17610 ENOG4107VQW regulatoR A9CBEGH2_17620 ENOG4105C2F Histidine kinase A9CBEGH2_17640 ENOG4105C4X radical SAM domain protein A9CBEGH2_17660 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) A9CBEGH2_17670 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A9CBEGH2_17680 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) A9CBEGH2_17700 ENOG4105C1J atp-dependent rna helicase A9CBEGH2_17750 ENOG4105C12 Phosphoribosylglycinamide synthetase A9CBEGH2_17780 ENOG4105DQ6 Transposase A9CBEGH2_17830 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) A9CBEGH2_18010 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component A9CBEGH2_18020 ENOG4105D2X ABC transporter substrate-binding protein A9CBEGH2_18050 ENOG4105DDW LysR family Transcriptional regulator A9CBEGH2_18090 ENOG4108IPW abc transporter atp-binding protein A9CBEGH2_18100 ENOG4105CM4 permease protein A9CBEGH2_18110 ENOG4105DHS permease protein A9CBEGH2_18120 ENOG4107QHE Choloylglycine hydrolase A9CBEGH2_18160 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A9CBEGH2_18200 ENOG4107EXU Short-chain dehydrogenase reductase Sdr A9CBEGH2_18220 ENOG4108JYZ YitT family A9CBEGH2_18250 ENOG4105VCQ rubredoxin A9CBEGH2_18260 ENOG4105CCI Myosin-Cross-Reactive Antigen A9CBEGH2_18290 ENOG4105DU0 nucleoside hydrolase A9CBEGH2_18300 ENOG4107R7I amino acid A9CBEGH2_18350 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase A9CBEGH2_18380 ENOG4105CPC Aldo Keto reductase A9CBEGH2_18400 ENOG4105UQX Mate efflux family protein A9CBEGH2_18410 ENOG4105UQX Mate efflux family protein A9CBEGH2_18480 ENOG4105CRK lysyL-tRNA synthetase A9CBEGH2_18500 ENOG4105C19 ABC transporter A9CBEGH2_18510 ENOG4105EWM Histidine kinase A9CBEGH2_18520 ENOG4105CJZ response regulator A9CBEGH2_18550 ENOG4105C7N Xanthine uracil vitamin C permease A9CBEGH2_18570 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A9CBEGH2_18580 ENOG4107SWG transcriptional regulator MERR family A9CBEGH2_18640 ENOG4108JA2 transcriptioN-repair coupling factor A9CBEGH2_18650 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A9CBEGH2_18670 ENOG4105C0D helicase A9CBEGH2_18710 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A9CBEGH2_18720 ENOG4108R6K riboflavin synthase, subunit alpha A9CBEGH2_18730 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A9CBEGH2_18750 ENOG4106128 DNA-binding helix-turn-helix protein A9CBEGH2_18790 ENOG4107RVG penicillin-binding protein A9CBEGH2_18800 ENOG4106WTF Glycosyl transferase, family 2 A9CBEGH2_18840 ENOG4108IJ2 phosphate acetyltransferase A9CBEGH2_18850 ENOG4108IJ2 phosphate acetyltransferase A9CBEGH2_18870 ENOG4105DC1 bifunctional purine biosynthesis protein purh A9CBEGH2_18880 ENOG4108V3E phosphoribosylglycinamide formyltransferase A9CBEGH2_18890 ENOG4105CXB phosphoribosylaminoimidazole synthetase A9CBEGH2_18900 ENOG4107QIK phosphoribosylformylglycinamidine synthase A9CBEGH2_18910 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A9CBEGH2_18950 ENOG4105EPR degv family A9CBEGH2_18960 ENOG4106HBN Galactosamine-6-phosphate isomerase A9CBEGH2_18980 ENOG4108X4Q Hydrolase A9CBEGH2_18990 ENOG4105F3R pts system mannose fructose sorbose family iid A9CBEGH2_19000 ENOG4105ETZ PTS System A9CBEGH2_19010 ENOG4108UZY PTS System A9CBEGH2_19020 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A9CBEGH2_19030 ENOG4108UZY PTS System A9CBEGH2_19040 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A9CBEGH2_19050 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A9CBEGH2_19060 ENOG4105MA4 psp1 domain protein A9CBEGH2_19070 ENOG4105FA2 dna polymerase iii A9CBEGH2_19080 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) A9CBEGH2_19090 ENOG4105DFA alanine racemase domain protein A9CBEGH2_19100 ENOG4105CUZ uba thif-type nad fad binding protein A9CBEGH2_19120 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) A9CBEGH2_19130 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) A9CBEGH2_19140 ENOG4105CNI cell division protein FtsW A9CBEGH2_19160 ENOG4105EMD TRANSCRIPTIONal A9CBEGH2_19170 ENOG4105CK1 PTS System A9CBEGH2_19180 ENOG4105VZJ PTS System A9CBEGH2_19190 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_19200 ENOG4105VCP PTS System A9CBEGH2_19240 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) A9CBEGH2_19250 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) A9CBEGH2_19260 ENOG4105C6E dna polymerase iii A9CBEGH2_19270 ENOG4108Z6B deaminase A9CBEGH2_19280 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A9CBEGH2_19290 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A9CBEGH2_19300 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A9CBEGH2_19310 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A9CBEGH2_19320 ENOG410848D S4 domain protein YaaA A9CBEGH2_19330 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A9CBEGH2_19340 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A9CBEGH2_19350 ENOG4105VG0 50S ribosomal protein l34 A9CBEGH2_19380 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein A9CBEGH2_19400 ENOG4108RS6 transposase A9CBEGH2_19410 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_19430 ENOG4105VCP PTS System A9CBEGH2_19470 ENOG4105CK1 PTS System A9CBEGH2_19490 ENOG4105RD7 BadF BadG BcrA BcrD A9CBEGH2_19520 ENOG4105UQX Mate efflux family protein A9CBEGH2_19580 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) A9CBEGH2_19590 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) A9CBEGH2_19610 ENOG4105CH2 amidohydrolase A9CBEGH2_19630 ENOG4105BZU Histidine kinase A9CBEGH2_19640 ENOG4105ETX regulatoR A9CBEGH2_19660 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A9CBEGH2_19670 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A9CBEGH2_19680 ENOG4105C2J ABC transporter A9CBEGH2_19720 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) A9CBEGH2_19730 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A9CBEGH2_19780 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A9CBEGH2_19820 ENOG4108WUZ (ABC) transporter A9CBEGH2_19880 ENOG4105CK1 PTS System A9CBEGH2_19890 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_19900 ENOG41066F8 ROK family A9CBEGH2_19930 ENOG4105VCP PTS System A9CBEGH2_19940 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_19970 ENOG4107RZC phospholipase d A9CBEGH2_19980 ENOG4105ESP cell wall surface anchor family protein A9CBEGH2_19990 ENOG4105CHM Aminotransferase A9CBEGH2_20000 ENOG4108ZB6 transcriptional regulator AsnC family A9CBEGH2_20020 ENOG4105C5Y PTS System A9CBEGH2_20040 ENOG4105C5Y PTS System A9CBEGH2_20050 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_20070 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein A9CBEGH2_20090 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A9CBEGH2_20120 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A9CBEGH2_20130 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A9CBEGH2_20150 ENOG4107SID ATP-dependent exodnase (exonuclease v) A9CBEGH2_20170 ENOG4105BZ1 (ABC) transporter A9CBEGH2_20180 ENOG4105BZ1 (ABC) transporter A9CBEGH2_20220 ENOG4105E0A ABC, transporter A9CBEGH2_20230 ENOG4105EHG Permease protein A9CBEGH2_20240 ENOG4105DQ5 transport system permease protein A9CBEGH2_20280 ENOG4107QW4 alcohol dehydrogenase A9CBEGH2_20380 ENOG4105DZR Type I site-specific deoxyribonuclease A9CBEGH2_20490 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) A9CBEGH2_20500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A9CBEGH2_20510 ENOG4105E2R ROK family A9CBEGH2_20530 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN A9CBEGH2_20540 ENOG4108YRF PTS System A9CBEGH2_20550 ENOG4105DM4 PTS System A9CBEGH2_20560 ENOG4105D2N Aldolase A9CBEGH2_20570 ENOG4105D2N Aldolase A9CBEGH2_20580 ENOG4108SU4 UPF0309 protein A9CBEGH2_20590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A9CBEGH2_20600 ENOG4108SWU Histidine kinase A9CBEGH2_20640 ENOG4108M14 stage v sporulation protein t A9CBEGH2_20650 ENOG41082I2 s4 domain protein A9CBEGH2_20670 ENOG4105C5Y PTS System A9CBEGH2_20680 ENOG4105C5Y PTS System A9CBEGH2_20690 ENOG4105CS2 ec 3.2.1.21 A9CBEGH2_20700 ENOG4108KP7 hydrolase A9CBEGH2_20740 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A9CBEGH2_20750 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) A9CBEGH2_20780 ENOG4107WCG it plays a direct role in the translocation of protons across the membrane (By similarity) A9CBEGH2_20800 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) A9CBEGH2_20810 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A9CBEGH2_20820 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A9CBEGH2_20830 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A9CBEGH2_20840 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) A9CBEGH2_20850 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A9CBEGH2_20870 ENOG4105BZ1 (ABC) transporter A9CBEGH2_20930 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A9CBEGH2_20940 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase A9CBEGH2_20950 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A9CBEGH2_20960 ENOG4105D49 3-dehydroquinate synthase A9CBEGH2_20980 ENOG4105CQC Prephenate dehydratase A9CBEGH2_21000 ENOG4105C3F Signal peptidase i A9CBEGH2_21010 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) A9CBEGH2_21030 ENOG41067MG lrgb family A9CBEGH2_21060 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A9CBEGH2_21070 ENOG4105XJC Two component transcriptional regulator (Winged helix family A9CBEGH2_21080 ENOG4105US7 Histidine kinase A9CBEGH2_21090 ENOG4105C0H protease A9CBEGH2_21110 ENOG4107WD8 ABC transporter, permease A9CBEGH2_21180 ENOG4107Y70 Heat shock protein A9CBEGH2_21200 ENOG4105VYY sporulation protein yabp A9CBEGH2_21260 ENOG4105BZ4 penicillin-binding protein A9CBEGH2_21280 ENOG4105C75 arginyL-tRNA synthetase A9CBEGH2_21340 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) A9CBEGH2_21360 ENOG4105VDK protein, conserved in bacteria A9CBEGH2_21390 ENOG4105C3G gtp-binding protein A9CBEGH2_21430 ENOG4105CHH sulfate transporter A9CBEGH2_21450 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A9CBEGH2_21490 ENOG4105D1H recombination factor protein RarA A9CBEGH2_21500 ENOG4105K59 histidine triad (HIT) protein A9CBEGH2_21510 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) A9CBEGH2_21570 ENOG4105CNU cell division protein FtsK A9CBEGH2_21610 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) A9CBEGH2_21620 ENOG4105I3K Ferric uptake regulator, Fur family A9CBEGH2_21630 ENOG4108RAC Rubrerythrin A9CBEGH2_21700 ENOG4105FDF Could be involved in DNA repair (By similarity) A9CBEGH2_21750 ENOG4105D3Q Sugar transferase A9CBEGH2_21770 ENOG4108PQP glycosyl transferase group 1 A9CBEGH2_21780 ENOG4105CG5 Glycosyl transferase (Group 1 A9CBEGH2_21800 ENOG4107T8Q Glycosyl transferase (Group 1 A9CBEGH2_21820 ENOG4105DCF alanine dehydrogenase A9CBEGH2_21880 ENOG4105D3Q Sugar transferase A9CBEGH2_21920 ENOG4108QV3 biosynthesis protein A9CBEGH2_21940 ENOG4107XU6 Glycosyl transferase (Group 1 A9CBEGH2_21950 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) A9CBEGH2_21970 ENOG4107ZBH radical SAM domain protein A9CBEGH2_22050 ENOG4105F5W AtP-binding protein A9CBEGH2_22140 ENOG4105EE0 oxidoreductase A9CBEGH2_22170 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A9CBEGH2_22240 ENOG4107YXZ hydrolase, family 25 A9CBEGH2_22270 ENOG4105CNW domain protein A9CBEGH2_22280 ENOG4105C1G acyl-Coa dehydrogenase A9CBEGH2_22290 ENOG4105CMR udp-glucose 4-epimerase A9CBEGH2_22300 ENOG4105D64 Mechanosensitive ion channel A9CBEGH2_22330 ENOG4105VEQ Cold shock protein A9CBEGH2_22350 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A9CBEGH2_22360 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A9CBEGH2_22370 ENOG4108JYZ YitT family A9CBEGH2_22380 ENOG4105CAK Cell division ATP-binding protein ftsE A9CBEGH2_22390 ENOG4105CRP Part of the ABC transporter FtsEX involved in A9CBEGH2_22400 ENOG4105DR5 peptidase A9CBEGH2_22410 ENOG4105CAK Cell division ATP-binding protein ftsE A9CBEGH2_22420 ENOG4105CRP Part of the ABC transporter FtsEX involved in A9CBEGH2_22430 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A9CBEGH2_22450 ENOG4108VZM 50s ribosomal protein L10 A9CBEGH2_22460 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A9CBEGH2_22470 ENOG4107Y49 methyltransferase A9CBEGH2_22480 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A9CBEGH2_22490 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A9CBEGH2_22510 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) A9CBEGH2_22520 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) A9CBEGH2_22550 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) A9CBEGH2_22560 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A9CBEGH2_22570 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) A9CBEGH2_22580 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) A9CBEGH2_22590 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity A9CBEGH2_22600 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) A9CBEGH2_22610 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) A9CBEGH2_22620 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) A9CBEGH2_22650 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal A9CBEGH2_22660 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) A9CBEGH2_22680 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A9CBEGH2_22690 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A9CBEGH2_22700 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) A9CBEGH2_22720 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) A9CBEGH2_22730 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) A9CBEGH2_22740 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) A9CBEGH2_22750 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A9CBEGH2_22760 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A9CBEGH2_22770 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A9CBEGH2_22790 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits A9CBEGH2_22800 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) A9CBEGH2_22810 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A9CBEGH2_22820 ENOG4108ZT0 50S ribosomal protein l17 A9CBEGH2_22860 ENOG4105CKI cobalamin synthesis protein A9CBEGH2_22900 ENOG4105BZ1 (ABC) transporter A9CBEGH2_22910 ENOG4105BZ1 (ABC) transporter A9CBEGH2_22930 ENOG4105EPR degv family A9CBEGH2_22970 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A9CBEGH2_22980 ENOG4105EMD TRANSCRIPTIONal A9CBEGH2_22990 ENOG4105CN9 Peptidase m42 family protein A9CBEGH2_23000 ENOG4105VCP PTS System A9CBEGH2_23010 ENOG4105VZJ PTS System A9CBEGH2_23020 ENOG4105CK1 PTS System A9CBEGH2_23030 ENOG4105DC7 peptidase M24 A9CBEGH2_23040 ENOG4105C87 Aminotransferase class I and II A9CBEGH2_23100 ENOG4105D38 putrescine abc transporter A9CBEGH2_23120 ENOG4105CRP Part of the ABC transporter FtsEX involved in A9CBEGH2_23150 ENOG4105DPN Oligoendopeptidase f A9CBEGH2_23160 ENOG4105DER m42 family A9CBEGH2_23170 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) A9CBEGH2_23210 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A9CBEGH2_23220 ENOG4105CPF Cell wall formation (By similarity) A9CBEGH2_23230 ENOG4108R6W Transcriptional regulator, ARAC family A9CBEGH2_23240 ENOG4105CT8 Phosphorylase A9CBEGH2_23270 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component A9CBEGH2_23320 ENOG4105C9X ppx gppa phosphatase A9CBEGH2_23330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A9CBEGH2_23380 ENOG4105ENV phosphonate C-P lyase system protein PhnK A9CBEGH2_23390 ENOG4105FD8 phosphonate metabolism protein PhnM A9CBEGH2_23410 ENOG4105HRV phosphonate c-p lyase system protein phnl A9CBEGH2_23420 ENOG4105DCG PHP domain protein A9CBEGH2_23430 ENOG4105ECY inositol monophosphatase A9CBEGH2_23460 ENOG4105D5T phosphonate abc transporter A9CBEGH2_23480 ENOG4105S7S phosphonate abc transporter A9CBEGH2_23550 ENOG4105VEQ Cold shock protein A9CBEGH2_23610 ENOG4105DPN Oligoendopeptidase f A9CBEGH2_23620 ENOG4105D3A purine nucleoside phosphorylase DeoD-type A9CBEGH2_23680 ENOG4105C4R Atp-dependent dna helicase A9CBEGH2_23690 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A9CBEGH2_23710 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A9CBEGH2_23720 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A9CBEGH2_23730 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A9CBEGH2_23750 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A9CBEGH2_23780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A9CBEGH2_23810 ENOG4105CJ1 ABC, transporter A9CBEGH2_23840 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A9CBEGH2_23890 ENOG4108HRK Histidine kinase A9CBEGH2_23900 ENOG4105EQD regulatoR A9CBEGH2_23920 ENOG4105BZA Phosphoglycerate kinase A9CBEGH2_23930 ENOG4105CP7 Triose-phosphate isomerase A9CBEGH2_23960 ENOG4108Z4T Peptidase M50 A9CBEGH2_23970 ENOG4105CP9 extracellular ligand-binding receptor A9CBEGH2_23980 ENOG4105C32 Amino acid ABC transporter (Permease) A9CBEGH2_23990 ENOG4105CF8 branched-chain amino acid ABC transporter, permease A9CBEGH2_24000 ENOG4105C0Z ABC transporter A9CBEGH2_24010 ENOG4108IV0 ABC, transporter A9CBEGH2_24030 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase A9CBEGH2_24040 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) A9CBEGH2_24060 ENOG4105CN1 protease A9CBEGH2_24070 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A9CBEGH2_24080 ENOG4105C02 permease A9CBEGH2_24100 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)