locus-tag	class	description
AA2016_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA2016_0002	COG0592	DNA-directed DNA polymerase activity
AA2016_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA2016_0008	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2016_0010	COG0735	belongs to the Fur family
AA2016_0011	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA2016_0013	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA2016_0014	COG3300	MHYT domain
AA2016_0014	COG5001	Diguanylate cyclase
AA2016_0015	COG2813	Specifically methylates the guanine in position
AA2016_0017	COG1185	polyribonucleotide nucleotidyltransferase activity
AA2016_0018	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA2016_0020	COG0598	Magnesium transport protein CorA
AA2016_0021	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA2016_0022	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA2016_0023	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA2016_0026	COG0779	Required for maturation of 30S ribosomal subunits
AA2016_0032	COG0745	RESPONSE REGULATOR receiver
AA2016_0034	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA2016_0035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA2016_0036	COG1396	sequence-specific DNA binding
AA2016_0037	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA2016_0039	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA2016_0040	COG1702	phosphate starvation-inducible protein PhoH
AA2016_0041	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2016_0045	COG1214	PFAM Peptidase M22, glycoprotease
AA2016_0046	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2016_0052	COG0481	GTPase activity
AA2016_0056	COG3220	belongs to the UPF0276 family
AA2016_0064	COG0671	phosphoesterase, PA-phosphatase related
AA2016_0066	COG0659	secondary active sulfate transmembrane transporter activity
AA2016_0067	COG0443	Heat shock 70 kDa protein
AA2016_0074	COG3795	YCII-related domain
AA2016_0077	COG0640	Transcriptional regulator
AA2016_0084	COG0842	Transport permease protein
AA2016_0085	COG1131	(ABC) transporter
AA2016_0092	COG1420	regulation of RNA biosynthetic process
AA2016_0093	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA2016_0095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA2016_0096	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2016_0100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA2016_0101	COG0792	nuclease activity
AA2016_0103	COG1254	Belongs to the acylphosphatase family
AA2016_0104	COG2124	cytochrome p450
AA2016_0108	COG0187	DNA topoisomerase II activity
AA2016_0110	COG0745	RESPONSE REGULATOR receiver
AA2016_0111	COG2205	protein histidine kinase activity
AA2016_0112	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA2016_0113	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AA2016_0114	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA2016_0119	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA2016_0120	COG2226	methyltransferase
AA2016_0121	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA2016_0122	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA2016_0126	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AA2016_0132	COG2900	Belongs to the SlyX family
AA2016_0135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_0139	COG2205	protein histidine kinase activity
AA2016_0140	COG0745	RESPONSE REGULATOR receiver
AA2016_0145	COG1477	protein flavinylation
AA2016_0148	COG1136	(ABC) transporter
AA2016_0148	COG0577	efflux transmembrane transporter activity
AA2016_0153	COG1278	Cold shock
AA2016_0159	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_0165	COG0251	oxidation-reduction process
AA2016_0168	COG0662	Cupin 2, conserved barrel domain protein
AA2016_0170	COG0848	biopolymer transport protein
AA2016_0177	COG4264	IucA IucC family
AA2016_0178	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_0180	COG1082	Xylose isomerase domain protein TIM barrel
AA2016_0181	COG4607	ABC-type enterochelin transport system periplasmic component
AA2016_0182	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_0183	COG4605	iron ion homeostasis
AA2016_0184	COG4604	ABC transporter, ATP-binding protein
AA2016_0185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA2016_0186	COG4638	Rieske (2fe-2S)
AA2016_0193	COG4771	TonB-dependent receptor
AA2016_0194	COG4178	(ABC) transporter
AA2016_0198	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA2016_0199	COG0459	protein refolding
AA2016_0203	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA2016_0207	COG0395	ABC-type sugar transport system, permease component
AA2016_0208	COG1175	transmembrane transport
AA2016_0211	COG1765	OsmC-like protein
AA2016_0212	COG2766	serine protein kinase
AA2016_0213	COG2718	Belongs to the UPF0229 family
AA2016_0214	COG2719	SpoVR family
AA2016_0215	COG3142	Participates in the control of copper homeostasis
AA2016_0216	COG1940	carbohydrate kinase activity
AA2016_0218	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_0219	COG1446	asparaginase
AA2016_0221	COG0765	amino acid transport
AA2016_0222	COG0765	amino acid transport
AA2016_0229	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA2016_0236	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_0237	COG1280	lysine exporter protein (LysE YggA)
AA2016_0238	COG1957	nucleoside hydrolase
AA2016_0241	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_0242	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA2016_0243	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AA2016_0244	COG1137	ATPase activity
AA2016_0245	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AA2016_0247	COG0616	signal peptide processing
AA2016_0248	COG0776	regulation of translation
AA2016_0250	COG2423	ornithine cyclodeaminase activity
AA2016_0253	COG2378	regulation of single-species biofilm formation
AA2016_0254	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA2016_0254	COG0116	Belongs to the methyltransferase superfamily
AA2016_0255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA2016_0256	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA2016_0258	COG2205	protein histidine kinase activity
AA2016_0258	COG0784	Response regulator, receiver
AA2016_0258	COG5002	protein histidine kinase activity
AA2016_0263	COG1252	NADH dehydrogenase
AA2016_0264	COG2860	membrane
AA2016_0265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA2016_0268	COG0175	sulfate reduction
AA2016_0269	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA2016_0271	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA2016_0271	COG1648	precorrin-2 dehydrogenase activity
AA2016_0273	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA2016_0273	COG4651	solute:proton antiporter activity
AA2016_0279	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA2016_0284	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_0285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_0286	COG1942	4-Oxalocrotonate Tautomerase
AA2016_0289	COG1733	regulation of RNA biosynthetic process
AA2016_0291	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_0291	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_0292	COG1280	lysine exporter protein (LysE YggA)
AA2016_0294	COG0667	Aldo Keto reductase
AA2016_0295	COG0673	inositol 2-dehydrogenase activity
AA2016_0298	COG0395	ABC-type sugar transport system, permease component
AA2016_0302	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AA2016_0305	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA2016_0306	COG1121	(ABC) transporter
AA2016_0307	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA2016_0308	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA2016_0309	COG3842	ATPase activity
AA2016_0310	COG0366	Alpha amylase catalytic
AA2016_0311	COG0395	ABC-type sugar transport system, permease component
AA2016_0312	COG1175	transmembrane transport
AA2016_0313	COG1653	transport
AA2016_0314	COG1609	Transcriptional regulator
AA2016_0315	COG1802	Transcriptional regulator
AA2016_0316	COG2272	Belongs to the type-B carboxylesterase lipase family
AA2016_0317	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA2016_0317	COG0543	2 iron, 2 sulfur cluster binding
AA2016_0320	COG1595	DNA-templated transcription, initiation
AA2016_0322	COG1404	Belongs to the peptidase S8 family
AA2016_0326	COG3811	Belongs to the UPF0386 family
AA2016_0330	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_0336	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0337	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_0339	COG0154	amidase activity
AA2016_0340	COG0747	negative chemotaxis
AA2016_0341	COG0601	transmembrane transport
AA2016_0342	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_0347	COG0625	glutathione transferase activity
AA2016_0360	COG0582	viral genome integration into host DNA
AA2016_0368	COG2199	diguanylate cyclase activity
AA2016_0369	COG4957	zinc ion binding
AA2016_0371	COG5001	Diguanylate cyclase
AA2016_0373	COG0583	DNA-binding transcription factor activity
AA2016_0377	COG4372	Transposase
AA2016_0384	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_0390	COG4964	Belongs to the GSP D family
AA2016_0406	COG4974	Belongs to the 'phage' integrase family
AA2016_0422	COG1072	(Pantothenic acid kinase))
AA2016_0423	COG0625	glutathione transferase activity
AA2016_0427	COG0829	nickel cation binding
AA2016_0428	COG0831	urea catabolic process
AA2016_0429	COG3813	Protein conserved in bacteria
AA2016_0431	COG0832	Belongs to the urease beta subunit family
AA2016_0436	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AA2016_0437	COG0830	nickel cation binding
AA2016_0439	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA2016_0441	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_0444	COG0534	Mate efflux family protein
AA2016_0447	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_0448	COG3842	ATPase activity
AA2016_0450	COG0765	amino acid transport
AA2016_0451	COG0765	amino acid transport
AA2016_0454	COG0583	DNA-binding transcription factor activity
AA2016_0455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA2016_0458	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_0460	COG1129	ABC transporter
AA2016_0463	COG1335	isochorismatase
AA2016_0469	COG1846	Transcriptional regulator
AA2016_0470	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_0471	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA2016_0476	COG0673	inositol 2-dehydrogenase activity
AA2016_0477	COG0395	ABC-type sugar transport system, permease component
AA2016_0480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA2016_0481	COG2971	BadF BadG BcrA BcrD
AA2016_0483	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA2016_0484	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA2016_0489	COG1879	ABC-type sugar transport system periplasmic component
AA2016_0491	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_0493	COG1609	Transcriptional regulator
AA2016_0497	COG4941	Belongs to the sigma-70 factor family
AA2016_0498	COG3795	YCII-related domain
AA2016_0499	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_0508	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AA2016_0509	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AA2016_0510	COG4335	DNA alkylation repair
AA2016_0514	COG0121	glutamine amidotransferase
AA2016_0516	COG1522	sequence-specific DNA binding
AA2016_0517	COG0756	dUTP diphosphatase activity
AA2016_0518	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_0519	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AA2016_0521	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_0522	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA2016_0523	COG0280	phosphate acetyltransferase
AA2016_0523	COG0281	malic enzyme
AA2016_0524	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA2016_0530	COG0596	Alpha beta hydrolase
AA2016_0533	COG0662	Cupin 2, conserved barrel domain protein
AA2016_0533	COG2207	Transcriptional regulator
AA2016_0540	COG5002	protein histidine kinase activity
AA2016_0540	COG5001	Diguanylate cyclase
AA2016_0542	COG0656	L-ascorbic acid biosynthetic process
AA2016_0547	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AA2016_0548	COG0728	peptidoglycan biosynthetic process
AA2016_0551	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AA2016_0551	COG0463	Glycosyl transferase, family 2
AA2016_0552	COG0180	Tryptophanyl-tRNA synthetase
AA2016_0554	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA2016_0555	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_0557	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AA2016_0559	COG1643	Atp-dependent helicase
AA2016_0561	COG0673	inositol 2-dehydrogenase activity
AA2016_0562	COG1737	Transcriptional regulator
AA2016_0563	COG0129	dihydroxy-acid dehydratase activity
AA2016_0565	COG0789	Transcriptional regulator
AA2016_0567	COG0626	cystathionine gamma-synthase activity
AA2016_0568	COG1846	Transcriptional regulator
AA2016_0569	COG0697	spore germination
AA2016_0573	COG1116	anion transmembrane transporter activity
AA2016_0575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_0577	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA2016_0581	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0584	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA2016_0585	COG1802	Transcriptional regulator
AA2016_0586	COG0579	oxidoreductase
AA2016_0588	COG1522	sequence-specific DNA binding
AA2016_0589	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA2016_0590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_0591	COG2186	Transcriptional regulator
AA2016_0592	COG0626	cystathionine gamma-synthase activity
AA2016_0595	COG0395	ABC-type sugar transport system, permease component
AA2016_0596	COG3842	ATPase activity
AA2016_0597	COG0840	transmembrane signaling receptor activity
AA2016_0598	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA2016_0599	COG2201	protein-glutamate methylesterase activity
AA2016_0600	COG0745	RESPONSE REGULATOR receiver
AA2016_0601	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AA2016_0608	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_0609	COG1063	alcohol dehydrogenase
AA2016_0611	COG4608	Belongs to the ABC transporter superfamily
AA2016_0613	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_0614	COG0601	transmembrane transport
AA2016_0617	COG2186	Transcriptional regulator
AA2016_0620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2016_0621	COG0346	lactoylglutathione lyase activity
AA2016_0622	COG0346	lactoylglutathione lyase activity
AA2016_0624	COG2124	cytochrome p450
AA2016_0630	COG1846	Transcriptional regulator
AA2016_0631	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA2016_0634	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_0638	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_0641	COG0436	Aminotransferase
AA2016_0643	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_0645	COG1473	amidohydrolase
AA2016_0646	COG1957	nucleoside hydrolase
AA2016_0647	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA2016_0649	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_0650	COG3842	ATPase activity
AA2016_0651	COG1177	transmembrane transport
AA2016_0652	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_0656	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_0658	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_0659	COG0601	transmembrane transport
AA2016_0662	COG4172	Belongs to the ABC transporter superfamily
AA2016_0663	COG4172	Belongs to the ABC transporter superfamily
AA2016_0667	COG0747	negative chemotaxis
AA2016_0672	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA2016_0673	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0674	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA2016_0675	COG0539	negative regulation of cytoplasmic translation
AA2016_0679	COG1309	transcriptional regulator
AA2016_0681	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_0682	COG4215	(ABC) transporter
AA2016_0684	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AA2016_0691	COG1968	undecaprenyl-diphosphatase activity
AA2016_0693	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA2016_0695	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AA2016_0696	COG1803	Methylglyoxal synthase
AA2016_0697	COG0837	glucose binding
AA2016_0698	COG1132	(ABC) transporter
AA2016_0699	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA2016_0700	COG0588	phosphoglycerate mutase activity
AA2016_0710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA2016_0712	COG3386	PFAM SMP-30 Gluconolaconase
AA2016_0713	COG0800	Aldolase
AA2016_0714	COG3734	2-keto-3-deoxy-galactonokinase
AA2016_0715	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0716	COG5001	Diguanylate cyclase
AA2016_0718	COG1309	transcriptional regulator
AA2016_0719	COG0189	ligase activity
AA2016_0722	COG5001	Diguanylate cyclase
AA2016_0727	COG0284	orotidine-5'-phosphate decarboxylase activity
AA2016_0729	COG3963	phosphatidate phosphatase activity
AA2016_0730	COG0484	heat shock protein binding
AA2016_0733	COG0443	Heat shock 70 kDa protein
AA2016_0738	COG3038	cytochrome b561
AA2016_0740	COG0072	phenylalanine-tRNA ligase activity
AA2016_0740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA2016_0742	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA2016_0743	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA2016_0744	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AA2016_0746	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA2016_0748	COG3135	benzoate transporter
AA2016_0751	COG0583	DNA-binding transcription factor activity
AA2016_0752	COG0135	phosphoribosylanthranilate isomerase activity
AA2016_0753	COG0133	tryptophan synthase activity
AA2016_0754	COG0159	tryptophan synthase activity
AA2016_0755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA2016_0758	COG1074	ATP-dependent DNA helicase activity
AA2016_0760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA2016_0761	COG3178	'Phosphotransferase
AA2016_0762	COG2205	protein histidine kinase activity
AA2016_0763	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA2016_0764	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_0765	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_0765	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AA2016_0767	COG2205	protein histidine kinase activity
AA2016_0768	COG0745	RESPONSE REGULATOR receiver
AA2016_0769	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AA2016_0770	COG2801	Transposase and inactivated derivatives
AA2016_0773	COG1652	LysM domain
AA2016_0774	COG3145	DNA-N1-methyladenine dioxygenase activity
AA2016_0775	COG1072	(Pantothenic acid kinase))
AA2016_0776	COG0140	phosphoribosyl-ATP diphosphatase activity
AA2016_0778	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA2016_0780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA2016_0782	COG0131	Imidazoleglycerol-phosphate dehydratase
AA2016_0783	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AA2016_0787	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AA2016_0789	COG1396	sequence-specific DNA binding
AA2016_0789	COG3800	Transcriptional regulator
AA2016_0793	COG3030	protein affecting phage T7 exclusion by the F plasmid
AA2016_0794	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AA2016_0795	COG2801	Transposase and inactivated derivatives
AA2016_0797	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AA2016_0798	COG0237	dephospho-CoA kinase activity
AA2016_0799	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA2016_0800	COG0424	maF-like protein
AA2016_0801	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AA2016_0802	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA2016_0804	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA2016_0805	COG1331	Highly conserved protein containing a thioredoxin domain
AA2016_0806	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA2016_0807	COG0445	tRNA wobble uridine modification
AA2016_0808	COG0357	Ribosomal RNA small subunit methyltransferase G
AA2016_0809	COG1192	Involved in chromosome partitioning
AA2016_0810	COG1475	DNA binding
AA2016_0822	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2016_0827	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA2016_0829	COG3800	Transcriptional regulator
AA2016_0829	COG1396	sequence-specific DNA binding
AA2016_0831	COG2183	response to ionizing radiation
AA2016_0832	COG0137	argininosuccinate synthase activity
AA2016_0838	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA2016_0839	COG0287	Prephenate dehydrogenase
AA2016_0839	COG1605	Chorismate mutase
AA2016_0840	COG0228	four-way junction DNA binding
AA2016_0841	COG3300	MHYT domain
AA2016_0841	COG5001	Diguanylate cyclase
AA2016_0843	COG3781	membrane
AA2016_0845	COG0454	-acetyltransferase
AA2016_0846	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA2016_0850	COG4178	(ABC) transporter
AA2016_0851	COG3152	Membrane
AA2016_0852	COG0473	3-isopropylmalate dehydrogenase activity
AA2016_0854	COG0251	oxidation-reduction process
AA2016_0856	COG0066	3-isopropylmalate dehydratase activity
AA2016_0857	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA2016_0858	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_0859	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_0860	COG1120	ATPase activity
AA2016_0861	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA2016_0863	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_0864	COG0525	valine-tRNA ligase activity
AA2016_0865	COG0765	amino acid transport
AA2016_0866	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_0869	COG2814	Major facilitator Superfamily
AA2016_0875	COG1595	DNA-templated transcription, initiation
AA2016_0882	COG2195	Cleaves the N-terminal amino acid of tripeptides
AA2016_0885	COG2301	Belongs to the HpcH HpaI aldolase family
AA2016_0889	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA2016_0890	COG0587	DNA-directed DNA polymerase activity
AA2016_0891	COG2835	tetraacyldisaccharide 4'-kinase activity
AA2016_0892	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA2016_0893	COG3118	belongs to the thioredoxin family
AA2016_0897	COG0436	Aminotransferase
AA2016_0901	COG0463	Glycosyl transferase, family 2
AA2016_0902	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA2016_0903	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0904	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_0905	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2016_0907	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_0908	COG1129	ABC transporter
AA2016_0910	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0912	COG4154	Belongs to the RbsD FucU family
AA2016_0913	COG4608	Belongs to the ABC transporter superfamily
AA2016_0914	COG0444	Belongs to the ABC transporter superfamily
AA2016_0916	COG0601	transmembrane transport
AA2016_0917	COG0747	negative chemotaxis
AA2016_0919	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA2016_0922	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA2016_0926	COG3339	Conserved Protein
AA2016_0927	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA2016_0928	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA2016_0931	COG1136	(ABC) transporter
AA2016_0932	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AA2016_0933	COG0670	Belongs to the BI1 family
AA2016_0935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA2016_0936	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_0940	COG2372	response to copper ion
AA2016_0940	COG1276	copper resistance
AA2016_0943	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0944	COG3300	MHYT domain
AA2016_0944	COG5001	Diguanylate cyclase
AA2016_0951	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AA2016_0953	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AA2016_0954	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2016_0955	COG0552	protein localization to endoplasmic reticulum
AA2016_0956	COG2917	probably involved in intracellular septation
AA2016_0958	COG0431	NADPH-dependent FMN reductase
AA2016_0961	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA2016_0963	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA2016_0964	COG4133	protoheme IX ABC transporter activity
AA2016_0965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AA2016_0967	COG0039	L-malate dehydrogenase activity
AA2016_0968	COG0045	succinate-CoA ligase (ADP-forming) activity
AA2016_0969	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AA2016_0970	COG0567	Dehydrogenase, E1 component
AA2016_0971	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_0974	COG1280	lysine exporter protein (LysE YggA)
AA2016_0976	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_0981	COG4974	Belongs to the 'phage' integrase family
AA2016_0982	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA2016_0983	COG0336	Belongs to the RNA methyltransferase TrmD family
AA2016_0985	COG0335	large ribosomal subunit rRNA binding
AA2016_0986	COG0456	acetyltransferase
AA2016_0990	COG0765	amino acid transport
AA2016_0995	COG1846	Transcriptional regulator
AA2016_0998	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA2016_0999	COG3706	GGDEF domain
AA2016_1007	COG3132	Protein of unknown function, DUF480
AA2016_1008	COG3541	Predicted nucleotidyltransferase
AA2016_1012	COG1764	response to oxidative stress
AA2016_1013	COG3795	YCII-related domain
AA2016_1014	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_1015	COG1946	Acyl-CoA thioesterase
AA2016_1016	COG0347	Belongs to the P(II) protein family
AA2016_1017	COG0004	ammonium transporteR
AA2016_1021	COG2261	transglycosylase associated protein
AA2016_1021	COG1674	ftsk spoiiie
AA2016_1022	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AA2016_1025	COG0745	RESPONSE REGULATOR receiver
AA2016_1028	COG0583	DNA-binding transcription factor activity
AA2016_1029	COG2264	protein methyltransferase activity
AA2016_1032	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA2016_1033	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA2016_1034	COG0181	hydroxymethylbilane synthase activity
AA2016_1039	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA2016_1044	COG3307	-O-antigen
AA2016_1045	COG1596	polysaccharide export
AA2016_1048	COG1215	transferase activity, transferring glycosyl groups
AA2016_1050	COG2273	Hydrolase Family 16
AA2016_1056	COG0438	transferase activity, transferring glycosyl groups
AA2016_1057	COG1215	transferase activity, transferring glycosyl groups
AA2016_1058	COG1215	transferase activity, transferring glycosyl groups
AA2016_1059	COG1215	transferase activity, transferring glycosyl groups
AA2016_1060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AA2016_1061	COG3206	protein involved in exopolysaccharide biosynthesis
AA2016_1061	COG0489	protein tyrosine kinase activity
AA2016_1064	COG3920	Histidine kinase
AA2016_1065	COG2755	lipolytic protein G-D-S-L family
AA2016_1065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA2016_1067	COG3239	Fatty acid desaturase
AA2016_1070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2016_1071	COG0747	negative chemotaxis
AA2016_1072	COG0601	transmembrane transport
AA2016_1073	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_1074	COG4172	Belongs to the ABC transporter superfamily
AA2016_1077	COG3284	Transcriptional regulator
AA2016_1081	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_1084	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2016_1087	COG1940	carbohydrate kinase activity
AA2016_1088	COG0730	response to heat
AA2016_1090	COG1802	Transcriptional regulator
AA2016_1091	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2016_1094	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_1098	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2016_1101	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_1105	COG2972	Histidine kinase
AA2016_1105	COG0840	transmembrane signaling receptor activity
AA2016_1107	COG0601	transmembrane transport
AA2016_1108	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_1110	COG1228	amidohydrolase
AA2016_1111	COG0444	Belongs to the ABC transporter superfamily
AA2016_1112	COG4608	Belongs to the ABC transporter superfamily
AA2016_1113	COG1802	Transcriptional regulator
AA2016_1114	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_1116	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_1117	COG0747	negative chemotaxis
AA2016_1118	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_1120	COG0747	negative chemotaxis
AA2016_1122	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_1123	COG0601	transmembrane transport
AA2016_1124	COG1802	Transcriptional regulator
AA2016_1128	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA2016_1131	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_1132	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_1144	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_1146	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA2016_1149	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2016_1150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA2016_1153	COG0583	DNA-binding transcription factor activity
AA2016_1156	COG2222	sugar isomerase
AA2016_1157	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_1158	COG4172	Belongs to the ABC transporter superfamily
AA2016_1159	COG0601	transmembrane transport
AA2016_1164	COG3547	Transposase (IS116 IS110 IS902 family)
AA2016_1170	COG2186	Transcriptional regulator
AA2016_1171	COG4638	Rieske (2fe-2S)
AA2016_1172	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AA2016_1175	COG3842	ATPase activity
AA2016_1176	COG1178	ABC-type Fe3 transport system permease component
AA2016_1178	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_1181	COG0028	Belongs to the TPP enzyme family
AA2016_1182	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_1188	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_1189	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA2016_1191	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AA2016_1192	COG4638	Rieske (2fe-2S)
AA2016_1193	COG2186	Transcriptional regulator
AA2016_1197	COG0129	dihydroxy-acid dehydratase activity
AA2016_1198	COG0163	prenyltransferase activity
AA2016_1204	COG0210	DNA helicase
AA2016_1205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA2016_1210	COG1525	nuclease
AA2016_1214	COG5410	chromosome segregation
AA2016_1222	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA2016_1223	COG1061	Type III restriction enzyme res subunit
AA2016_1225	COG1002	Type II restriction enzyme, methylase subunits
AA2016_1232	COG1872	DUF167
AA2016_1234	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA2016_1239	COG1704	LemA family
AA2016_1247	COG2814	Major facilitator Superfamily
AA2016_1248	COG1846	Transcriptional regulator
AA2016_1249	COG0339	signal peptide processing
AA2016_1255	COG2270	Major facilitator Superfamily
AA2016_1256	COG0138	bifunctional purine biosynthesis protein purh
AA2016_1258	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA2016_1258	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA2016_1259	COG0501	Belongs to the peptidase M48B family
AA2016_1264	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA2016_1265	COG0789	Transcriptional regulator
AA2016_1267	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2016_1268	COG5425	PFAM Usg family protein
AA2016_1270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AA2016_1271	COG0495	leucyl-tRNA aminoacylation
AA2016_1273	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA2016_1275	COG1522	sequence-specific DNA binding
AA2016_1276	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA2016_1280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA2016_1282	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA2016_1283	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA2016_1284	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA2016_1285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA2016_1286	COG0590	tRNA wobble adenosine to inosine editing
AA2016_1289	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AA2016_1291	COG1091	dTDP-4-dehydrorhamnose reductase activity
AA2016_1293	COG3754	Rhamnan synthesis protein F
AA2016_1297	COG3743	rRNA binding
AA2016_1297	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA2016_1298	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA2016_1301	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA2016_1302	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA2016_1303	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA2016_1304	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA2016_1307	COG0799	negative regulation of ribosome biogenesis
AA2016_1308	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AA2016_1310	COG0793	Belongs to the peptidase S41A family
AA2016_1312	COG0494	nUDIX hydrolase
AA2016_1313	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2016_1315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_1321	COG3655	Transcriptional regulator
AA2016_1326	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_1327	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_1332	COG0410	ABC transporter
AA2016_1335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AA2016_1337	COG2223	nitrite transmembrane transporter activity
AA2016_1338	COG0583	DNA-binding transcription factor activity
AA2016_1342	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA2016_1345	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_1347	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA2016_1348	COG0741	lytic transglycosylase activity
AA2016_1349	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_1353	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA2016_1354	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA2016_1357	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AA2016_1358	COG0183	Belongs to the thiolase family
AA2016_1359	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_1361	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AA2016_1364	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA2016_1365	COG1329	Transcriptional regulator
AA2016_1367	COG1126	abc transporter atp-binding protein
AA2016_1369	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_1370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA2016_1372	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AA2016_1379	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA2016_1381	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA2016_1382	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AA2016_1387	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA2016_1390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA2016_1391	COG0037	tRNA processing
AA2016_1393	COG2885	chlorophyll binding
AA2016_1396	COG0848	biopolymer transport protein
AA2016_1398	COG0824	Thioesterase
AA2016_1399	COG2226	methyltransferase
AA2016_1401	COG1408	metallophosphoesterase
AA2016_1403	COG2255	four-way junction helicase activity
AA2016_1408	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA2016_1412	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_1416	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA2016_1417	COG0483	inositol monophosphate 1-phosphatase activity
AA2016_1418	COG1272	protein, Hemolysin III
AA2016_1428	COG0778	Nitroreductase
AA2016_1429	COG1132	(ABC) transporter
AA2016_1430	COG0254	rRNA binding
AA2016_1433	COG0702	epimerase
AA2016_1435	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA2016_1437	COG0217	transcriptional regulatory protein
AA2016_1440	COG0625	glutathione transferase activity
AA2016_1441	COG1733	regulation of RNA biosynthetic process
AA2016_1446	COG0861	Integral membrane protein TerC family
AA2016_1447	COG1692	metallophosphoesterase
AA2016_1448	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA2016_1454	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_1458	COG0583	DNA-binding transcription factor activity
AA2016_1459	COG0431	NADPH-dependent FMN reductase
AA2016_1460	COG3750	Belongs to the UPF0335 family
AA2016_1464	COG0469	pyruvate kinase activity
AA2016_1465	COG2267	carboxylic ester hydrolase activity
AA2016_1466	COG0457	Tetratricopeptide repeat
AA2016_1467	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AA2016_1468	COG3755	Protein conserved in bacteria
AA2016_1469	COG1733	regulation of RNA biosynthetic process
AA2016_1472	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AA2016_1476	COG0640	Transcriptional regulator
AA2016_1479	COG0604	alcohol dehydrogenase
AA2016_1479	COG3321	synthase
AA2016_1479	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_1480	COG2226	methyltransferase
AA2016_1482	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_1484	COG0145	ligase activity
AA2016_1485	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AA2016_1491	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA2016_1491	COG0045	succinate-CoA ligase (ADP-forming) activity
AA2016_1491	COG1042	CoA-binding domain protein
AA2016_1493	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_1494	COG0697	spore germination
AA2016_1497	COG0183	Belongs to the thiolase family
AA2016_1501	COG4191	Histidine kinase
AA2016_1506	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_1511	COG2801	Transposase and inactivated derivatives
AA2016_1526	COG0640	Transcriptional regulator
AA2016_1527	COG2268	Band 7 protein
AA2016_1530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA2016_1544	COG2801	Transposase and inactivated derivatives
AA2016_1546	COG3588	fructose-bisphosphate aldolase
AA2016_1548	COG0126	phosphoglycerate kinase activity
AA2016_1557	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA2016_1558	COG0564	pseudouridine synthase activity
AA2016_1560	COG0346	lactoylglutathione lyase activity
AA2016_1592	COG0573	inorganic phosphate transmembrane transporter activity
AA2016_1595	COG0704	Plays a role in the regulation of phosphate uptake
AA2016_1596	COG0745	RESPONSE REGULATOR receiver
AA2016_1598	COG4213	ABC transporter substrate-binding protein
AA2016_1599	COG4214	carbohydrate transport
AA2016_1604	COG2202	Pas domain
AA2016_1604	COG3920	Histidine kinase
AA2016_1606	COG0784	Response regulator, receiver
AA2016_1608	COG0784	Response regulator, receiver
AA2016_1609	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_1610	COG0628	permease
AA2016_1617	COG0346	lactoylglutathione lyase activity
AA2016_1618	COG0400	carboxylic ester hydrolase activity
AA2016_1622	COG2199	diguanylate cyclase activity
AA2016_1622	COG2200	EAL domain
AA2016_1622	COG2203	Gaf domain
AA2016_1623	COG0745	RESPONSE REGULATOR receiver
AA2016_1624	COG0745	RESPONSE REGULATOR receiver
AA2016_1627	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA2016_1628	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AA2016_1629	COG3833	ABC-type maltose transport systems, permease component
AA2016_1630	COG3842	ATPase activity
AA2016_1633	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AA2016_1636	COG0483	inositol monophosphate 1-phosphatase activity
AA2016_1641	COG1840	ABC-type Fe3 transport system, periplasmic component
AA2016_1643	COG3842	ATPase activity
AA2016_1644	COG1238	metal cluster binding
AA2016_1646	COG2132	Multicopper oxidase
AA2016_1652	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA2016_1653	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA2016_1655	COG1845	cytochrome c oxidase, subunit III
AA2016_1658	COG0406	alpha-ribazole phosphatase activity
AA2016_1659	COG3842	ATPase activity
AA2016_1660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA2016_1664	COG1737	Transcriptional regulator
AA2016_1666	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_1669	COG0395	ABC-type sugar transport system, permease component
AA2016_1673	COG1129	ABC transporter
AA2016_1675	COG2186	Transcriptional regulator
AA2016_1679	COG0625	glutathione transferase activity
AA2016_1680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA2016_1682	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AA2016_1683	COG0352	thiamine-phosphate diphosphorylase activity
AA2016_1683	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AA2016_1683	COG0351	phosphomethylpyrimidine kinase
AA2016_1685	COG2022	thiamine diphosphate biosynthetic process
AA2016_1688	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA2016_1693	COG0356	it plays a direct role in the translocation of protons across the membrane
AA2016_1695	COG1473	amidohydrolase
AA2016_1696	COG1686	Belongs to the peptidase S11 family
AA2016_1697	COG0523	cobalamin synthesis protein
AA2016_1698	COG0425	Belongs to the sulfur carrier protein TusA family
AA2016_1700	COG0825	malonyl-CoA metabolic process
AA2016_1702	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA2016_1703	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA2016_1704	COG4536	flavin adenine dinucleotide binding
AA2016_1715	COG1522	sequence-specific DNA binding
AA2016_1720	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AA2016_1721	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA2016_1725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_1726	COG2226	methyltransferase
AA2016_1729	COG1597	lipid kinase activity
AA2016_1731	COG2814	Major facilitator Superfamily
AA2016_1732	COG0583	DNA-binding transcription factor activity
AA2016_1733	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AA2016_1734	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA2016_1735	COG0287	Prephenate dehydrogenase
AA2016_1738	COG2169	Transcriptional regulator
AA2016_1738	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA2016_1742	COG2884	Cell division ATP-binding protein ftsE
AA2016_1747	COG0583	DNA-binding transcription factor activity
AA2016_1750	COG0019	diaminopimelate decarboxylase activity
AA2016_1752	COG0165	Argininosuccinate lyase
AA2016_1753	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA2016_1754	COG1653	transport
AA2016_1755	COG1175	transmembrane transport
AA2016_1756	COG0395	ABC-type sugar transport system, permease component
AA2016_1757	COG3842	ATPase activity
AA2016_1758	COG3706	GGDEF domain
AA2016_1759	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_1761	COG2086	electron transfer activity
AA2016_1765	COG0300	oxidoreductase activity
AA2016_1767	COG0697	spore germination
AA2016_1769	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2016_1773	COG1238	metal cluster binding
AA2016_1778	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2016_1782	COG2239	Acts as a magnesium transporter
AA2016_1783	COG0653	protein targeting
AA2016_1784	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA2016_1789	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA2016_1790	COG0456	acetyltransferase
AA2016_1791	COG0494	nUDIX hydrolase
AA2016_1794	COG2226	methyltransferase
AA2016_1795	COG1040	competence protein
AA2016_1797	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA2016_1802	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_1803	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_1804	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA2016_1805	COG0527	aspartate kinase activity
AA2016_1807	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA2016_1808	COG2890	protein-(glutamine-N5) methyltransferase activity
AA2016_1810	COG0542	response to heat
AA2016_1812	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_1817	COG0625	glutathione transferase activity
AA2016_1818	COG0477	Major facilitator Superfamily
AA2016_1819	COG0741	lytic transglycosylase activity
AA2016_1819	COG1196	nuclear chromosome segregation
AA2016_1819	COG0739	heme binding
AA2016_1823	COG4176	ABC-type proline glycine betaine transport system permease component
AA2016_1824	COG4175	Glycine betaine
AA2016_1824	COG3448	diguanylate cyclase activity
AA2016_1826	COG0745	RESPONSE REGULATOR receiver
AA2016_1827	COG2205	protein histidine kinase activity
AA2016_1829	COG0745	RESPONSE REGULATOR receiver
AA2016_1831	COG1879	ABC-type sugar transport system periplasmic component
AA2016_1832	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_1834	COG3842	ATPase activity
AA2016_1838	COG1070	Carbohydrate kinase
AA2016_1840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA2016_1841	COG0667	Aldo Keto reductase
AA2016_1843	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_1844	COG1129	ABC transporter
AA2016_1848	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_1850	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AA2016_1858	COG0463	Glycosyl transferase, family 2
AA2016_1859	COG1215	transferase activity, transferring glycosyl groups
AA2016_1862	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_1863	COG1120	ATPase activity
AA2016_1864	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_1867	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_1868	COG0205	6-phosphofructokinase activity
AA2016_1869	COG1388	LysM domain
AA2016_1869	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_1870	COG1280	lysine exporter protein (LysE YggA)
AA2016_1872	COG1070	Carbohydrate kinase
AA2016_1874	COG2115	Belongs to the xylose isomerase family
AA2016_1878	COG4977	sequence-specific DNA binding
AA2016_1879	COG3246	L-lysine catabolic process to acetate
AA2016_1880	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_1886	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_1891	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AA2016_1892	COG3257	ureidoglycine aminohydrolase activity
AA2016_1894	COG2351	hydroxyisourate hydrolase activity
AA2016_1896	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA2016_1898	COG0783	Belongs to the Dps family
AA2016_1899	COG1733	regulation of RNA biosynthetic process
AA2016_1901	COG0583	DNA-binding transcription factor activity
AA2016_1903	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_1904	COG4702	Belongs to the UPF0303 family
AA2016_1908	COG0174	glutamine synthetase
AA2016_1914	COG0523	cobalamin synthesis protein
AA2016_1916	COG1846	Transcriptional regulator
AA2016_1919	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2016_1921	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA2016_1922	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2016_1923	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2016_1925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2016_1931	COG5001	Diguanylate cyclase
AA2016_1935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AA2016_1936	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AA2016_1937	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AA2016_1939	COG1280	lysine exporter protein (LysE YggA)
AA2016_1941	COG2249	NAD(P)H dehydrogenase (quinone) activity
AA2016_1943	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AA2016_1947	COG2223	nitrite transmembrane transporter activity
AA2016_1950	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_1952	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_1955	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_1955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_1967	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2016_1975	COG3842	ATPase activity
AA2016_1976	COG0583	DNA-binding transcription factor activity
AA2016_1977	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AA2016_1978	COG3842	ATPase activity
AA2016_1979	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_1980	COG1177	transmembrane transport
AA2016_1981	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_1984	COG1609	Transcriptional regulator
AA2016_1987	COG1024	Enoyl-CoA hydratase
AA2016_1988	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_1989	COG1653	transport
AA2016_1991	COG0395	ABC-type sugar transport system, permease component
AA2016_1992	COG3842	ATPase activity
AA2016_1994	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_1996	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA2016_1997	COG3774	pathogenesis
AA2016_1998	COG4608	Belongs to the ABC transporter superfamily
AA2016_1999	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_2000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_2002	COG4533	DNA binding
AA2016_2003	COG0444	Belongs to the ABC transporter superfamily
AA2016_2009	COG2072	flavoprotein involved in K transport
AA2016_2014	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_2017	COG0069	glutamate synthase activity
AA2016_2017	COG0067	glutamate synthase
AA2016_2017	COG0070	glutamate synthase
AA2016_2020	COG2951	lytic endotransglycosylase activity
AA2016_2021	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AA2016_2022	COG0778	Nitroreductase
AA2016_2027	COG1585	Membrane protein implicated in regulation of membrane protease activity
AA2016_2028	COG0330	HflC and HflK could
AA2016_2029	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_2029	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA2016_2030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA2016_2031	COG0737	Belongs to the 5'-nucleotidase family
AA2016_2033	COG3775	system Galactitol-specific IIC component
AA2016_2036	COG5310	Homospermidine synthase
AA2016_2043	COG2204	response regulator
AA2016_2044	COG3108	Peptidase M15
AA2016_2045	COG0800	Aldolase
AA2016_2049	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_2061	COG0583	DNA-binding transcription factor activity
AA2016_2062	COG0154	amidase activity
AA2016_2067	COG2801	Transposase and inactivated derivatives
AA2016_2074	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA2016_2075	COG2814	Major facilitator Superfamily
AA2016_2077	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AA2016_2078	COG5443	negative regulation of bacterial-type flagellum assembly
AA2016_2079	COG5442	Flagellar protein FlaF
AA2016_2082	COG1749	Flagellar hook protein flgE
AA2016_2090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_2091	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_2092	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_2094	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_2095	COG1338	Plays a role in the flagellum-specific transport system
AA2016_2097	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AA2016_2099	COG1706	bacterial-type flagellum-dependent cell motility
AA2016_2100	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AA2016_2101	COG4786	Flagellar basal body rod
AA2016_2102	COG1677	Flagellar hook-basal body complex protein FliE
AA2016_2103	COG1558	bacterial-type flagellum-dependent cell motility
AA2016_2104	COG1815	bacterial-type flagellum-dependent cell motility
AA2016_2106	COG1157	protein secretion by the type III secretion system
AA2016_2107	COG4786	Flagellar basal body rod
AA2016_2109	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AA2016_2111	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AA2016_2112	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AA2016_2113	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA2016_2116	COG2771	luxR family
AA2016_2119	COG1309	transcriptional regulator
AA2016_2120	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AA2016_2121	COG3842	ATPase activity
AA2016_2122	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_2123	COG1177	transmembrane transport
AA2016_2129	COG4213	ABC transporter substrate-binding protein
AA2016_2130	COG1129	ABC transporter
AA2016_2131	COG4214	carbohydrate transport
AA2016_2141	COG1129	ABC transporter
AA2016_2142	COG4211	Belongs to the binding-protein-dependent transport system permease family
AA2016_2143	COG0673	inositol 2-dehydrogenase activity
AA2016_2144	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_2145	COG3962	Belongs to the TPP enzyme family
AA2016_2146	COG1082	Xylose isomerase domain protein TIM barrel
AA2016_2148	COG3718	enzyme involved in inositol metabolism
AA2016_2149	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA2016_2155	COG2197	response regulator
AA2016_2159	COG0747	negative chemotaxis
AA2016_2163	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_2164	COG0747	negative chemotaxis
AA2016_2167	COG3454	Phosphonate metabolism
AA2016_2168	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AA2016_2169	COG3639	organic phosphonate transmembrane transporter activity
AA2016_2172	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA2016_2173	COG1733	regulation of RNA biosynthetic process
AA2016_2176	COG0786	glutamate:sodium symporter activity
AA2016_2178	COG4778	phosphonate C-P lyase system protein PhnL
AA2016_2179	COG4107	phosphonate C-P lyase system protein PhnK
AA2016_2180	COG3627	carbon phosphorus lyase activity
AA2016_2181	COG3626	phosphonate metabolism
AA2016_2182	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AA2016_2183	COG3624	Phosphonate C-P lyase system protein PhnG
AA2016_2184	COG2188	Transcriptional regulator
AA2016_2186	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_2187	COG1177	transmembrane transport
AA2016_2189	COG2072	flavoprotein involved in K transport
AA2016_2192	COG3620	sequence-specific DNA binding
AA2016_2199	COG0583	DNA-binding transcription factor activity
AA2016_2200	COG3842	ATPase activity
AA2016_2202	COG1175	transmembrane transport
AA2016_2241	COG0740	serine-type endopeptidase activity
AA2016_2269	COG3620	sequence-specific DNA binding
AA2016_2280	COG5377	YqaJ viral recombinase family
AA2016_2286	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AA2016_2289	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA2016_2289	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AA2016_2299	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AA2016_2301	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA2016_2314	COG0482	sulfurtransferase activity
AA2016_2317	COG0604	alcohol dehydrogenase
AA2016_2318	COG1733	regulation of RNA biosynthetic process
AA2016_2321	COG2201	protein-glutamate methylesterase activity
AA2016_2330	COG0435	Glutathione S-transferase
AA2016_2331	COG0494	nUDIX hydrolase
AA2016_2334	COG0596	Alpha beta hydrolase
AA2016_2334	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_2336	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA2016_2338	COG3180	Ammonia monooxygenase
AA2016_2344	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA2016_2344	COG0512	Glutamine amidotransferase of anthranilate synthase
AA2016_2346	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_2348	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA2016_2349	COG2814	Major facilitator Superfamily
AA2016_2350	COG0583	DNA-binding transcription factor activity
AA2016_2351	COG4993	Dehydrogenase
AA2016_2353	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AA2016_2357	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA2016_2362	COG0789	Transcriptional regulator
AA2016_2364	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AA2016_2370	COG1435	thymidine kinase activity
AA2016_2372	COG4176	ABC-type proline glycine betaine transport system permease component
AA2016_2373	COG3448	diguanylate cyclase activity
AA2016_2373	COG4175	Glycine betaine
AA2016_2377	COG5507	3-demethylubiquinone-9 3-methyltransferase
AA2016_2378	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA2016_2383	COG1278	Cold shock
AA2016_2388	COG0714	Associated with various cellular activities
AA2016_2390	COG0494	nUDIX hydrolase
AA2016_2391	COG0617	tRNA 3'-terminal CCA addition
AA2016_2395	COG0408	coproporphyrinogen oxidase activity
AA2016_2401	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AA2016_2403	COG1132	(ABC) transporter
AA2016_2404	COG1132	(ABC) transporter
AA2016_2405	COG1132	(ABC) transporter
AA2016_2409	COG2857	Cytochrome c1
AA2016_2409	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA2016_2410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA2016_2416	COG0012	GTP binding
AA2016_2417	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AA2016_2418	COG0193	aminoacyl-tRNA hydrolase activity
AA2016_2419	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA2016_2423	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA2016_2428	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA2016_2431	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA2016_2433	COG1464	Belongs to the NlpA lipoprotein family
AA2016_2434	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA2016_2435	COG2011	ABC-type metal ion transport system permease component
AA2016_2436	COG2205	protein histidine kinase activity
AA2016_2438	COG0745	RESPONSE REGULATOR receiver
AA2016_2439	COG1846	Transcriptional regulator
AA2016_2440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_2442	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_2444	COG1278	Cold shock
AA2016_2446	COG1278	Cold shock
AA2016_2451	COG0583	DNA-binding transcription factor activity
AA2016_2453	COG1819	glycosyl
AA2016_2455	COG1794	racemase activity, acting on amino acids and derivatives
AA2016_2457	COG3791	Glutathione-dependent formaldehyde-activating
AA2016_2459	COG0726	polysaccharide deacetylase
AA2016_2463	COG1396	sequence-specific DNA binding
AA2016_2470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_2472	COG1522	sequence-specific DNA binding
AA2016_2475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_2479	COG0583	DNA-binding transcription factor activity
AA2016_2482	COG0556	nucleotide-excision repair
AA2016_2484	COG0438	transferase activity, transferring glycosyl groups
AA2016_2490	COG1597	lipid kinase activity
AA2016_2492	COG2084	Dehydrogenase
AA2016_2493	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_2495	COG1607	acyl-coa hydrolase
AA2016_2498	COG1253	flavin adenine dinucleotide binding
AA2016_2506	COG0583	DNA-binding transcription factor activity
AA2016_2508	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_2511	COG2133	pyrroloquinoline quinone binding
AA2016_2512	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2016_2515	COG3306	glycosyltransferase involved in LPS biosynthesis
AA2016_2516	COG3306	glycosyltransferase involved in LPS biosynthesis
AA2016_2518	COG1522	sequence-specific DNA binding
AA2016_2519	COG0492	ferredoxin-NADP+ reductase activity
AA2016_2520	COG0583	DNA-binding transcription factor activity
AA2016_2521	COG0640	Transcriptional regulator
AA2016_2526	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA2016_2527	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA2016_2530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA2016_2532	COG1733	regulation of RNA biosynthetic process
AA2016_2533	COG0477	Major facilitator Superfamily
AA2016_2543	COG1278	Cold shock
AA2016_2545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA2016_2550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA2016_2552	COG2130	NADP-dependent
AA2016_2554	COG3591	Belongs to the peptidase S1B family
AA2016_2554	COG1864	DNA RNA non-specific endonuclease
AA2016_2557	COG2814	Major facilitator Superfamily
AA2016_2560	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_2562	COG2321	neutral zinc metallopeptidase
AA2016_2563	COG4989	oxidoreductase activity
AA2016_2572	COG0505	Belongs to the CarA family
AA2016_2575	COG1473	amidohydrolase
AA2016_2577	COG0358	DNA primase activity
AA2016_2578	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA2016_2581	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AA2016_2584	COG0372	Belongs to the citrate synthase family
AA2016_2585	COG0372	Belongs to the citrate synthase family
AA2016_2593	COG1280	lysine exporter protein (LysE YggA)
AA2016_2602	COG0488	(ABC) transporter
AA2016_2605	COG1522	sequence-specific DNA binding
AA2016_2607	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA2016_2608	COG0583	DNA-binding transcription factor activity
AA2016_2609	COG1309	transcriptional regulator
AA2016_2615	COG2862	Uncharacterized protein family, UPF0114
AA2016_2617	COG2983	Belongs to the UPF0260 family
AA2016_2623	COG1760	l-serine dehydratase
AA2016_2624	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_2624	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_2625	COG0509	glycine decarboxylation via glycine cleavage system
AA2016_2626	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_2629	COG0583	DNA-binding transcription factor activity
AA2016_2630	COG1309	transcriptional regulator
AA2016_2631	COG1744	ABC transporter substrate-binding protein PnrA-like
AA2016_2639	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_2640	COG1414	Transcriptional regulator
AA2016_2641	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA2016_2642	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AA2016_2645	COG1309	transcriptional regulator
AA2016_2646	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_2649	COG1609	Transcriptional regulator
AA2016_2649	COG2207	Transcriptional regulator
AA2016_2650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_2653	COG1609	Transcriptional regulator
AA2016_2655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_2660	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_2668	COG3842	ATPase activity
AA2016_2669	COG1082	Xylose isomerase domain protein TIM barrel
AA2016_2673	COG2814	Major facilitator Superfamily
AA2016_2675	COG4608	Belongs to the ABC transporter superfamily
AA2016_2676	COG0444	Belongs to the ABC transporter superfamily
AA2016_2677	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_2678	COG0601	transmembrane transport
AA2016_2679	COG0747	negative chemotaxis
AA2016_2682	COG1473	amidohydrolase
AA2016_2683	COG1473	amidohydrolase
AA2016_2684	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_2685	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_2687	COG5383	Protein conserved in bacteria
AA2016_2689	COG1737	Transcriptional regulator
AA2016_2689	COG0837	glucose binding
AA2016_2690	COG0747	negative chemotaxis
AA2016_2691	COG0601	transmembrane transport
AA2016_2693	COG0444	Belongs to the ABC transporter superfamily
AA2016_2698	COG3706	GGDEF domain
AA2016_2701	COG0463	Glycosyl transferase, family 2
AA2016_2712	COG0367	asparagine synthase
AA2016_2714	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_2715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA2016_2722	COG1902	pentaerythritol trinitrate reductase activity
AA2016_2726	COG0673	inositol 2-dehydrogenase activity
AA2016_2728	COG0589	response to stress
AA2016_2729	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_2730	COG4597	amino acid ABC transporter
AA2016_2731	COG0765	amino acid transport
AA2016_2733	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA2016_2734	COG4208	sulfate ABC transporter
AA2016_2735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA2016_2736	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA2016_2740	COG4953	penicillin-binding protein 1C
AA2016_2742	COG0729	surface antigen
AA2016_2744	COG4166	transmembrane transport
AA2016_2745	COG0601	transmembrane transport
AA2016_2746	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_2748	COG0493	'glutamate synthase
AA2016_2752	COG1959	2 iron, 2 sulfur cluster binding
AA2016_2759	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_2760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_2765	COG0028	Belongs to the TPP enzyme family
AA2016_2766	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA2016_2767	COG2267	carboxylic ester hydrolase activity
AA2016_2768	COG1131	(ABC) transporter
AA2016_2769	COG0842	Transport permease protein
AA2016_2775	COG4106	trans-aconitate 2-methyltransferase activity
AA2016_2778	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_2779	COG1522	sequence-specific DNA binding
AA2016_2781	COG1720	tRNA m6t6A37 methyltransferase activity
AA2016_2786	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA2016_2793	COG0697	spore germination
AA2016_2794	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA2016_2798	COG0626	cystathionine gamma-synthase activity
AA2016_2799	COG2001	Belongs to the MraZ family
AA2016_2800	COG0275	rRNA processing
AA2016_2803	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA2016_2805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA2016_2806	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA2016_2808	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA2016_2809	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA2016_2810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA2016_2811	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA2016_2812	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AA2016_2813	COG0849	cell division
AA2016_2814	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA2016_2816	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA2016_2819	COG2176	DNA-directed DNA polymerase activity
AA2016_2822	COG0006	proline dipeptidase activity
AA2016_2823	COG2264	protein methyltransferase activity
AA2016_2824	COG1999	signal sequence binding
AA2016_2827	COG0110	maltose O-acetyltransferase activity
AA2016_2831	COG5002	protein histidine kinase activity
AA2016_2832	COG0745	RESPONSE REGULATOR receiver
AA2016_2835	COG0210	DNA helicase
AA2016_2840	COG0277	FAD linked oxidase domain protein
AA2016_2848	COG2814	Major facilitator Superfamily
AA2016_2849	COG3706	GGDEF domain
AA2016_2853	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AA2016_2856	COG0330	HflC and HflK could
AA2016_2857	COG0330	HflC and HflK could
AA2016_2859	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA2016_2861	COG0560	Phosphoserine phosphatase
AA2016_2861	COG3830	Belongs to the UPF0237 family
AA2016_2862	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA2016_2863	COG3706	GGDEF domain
AA2016_2864	COG2267	carboxylic ester hydrolase activity
AA2016_2866	COG1132	(ABC) transporter
AA2016_2867	COG0028	Belongs to the TPP enzyme family
AA2016_2868	COG0440	acetolactate synthase activity
AA2016_2878	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AA2016_2882	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AA2016_2883	COG3158	transport of potassium into the cell
AA2016_2884	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_2888	COG0583	DNA-binding transcription factor activity
AA2016_2890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA2016_2896	COG1136	(ABC) transporter
AA2016_2896	COG0577	efflux transmembrane transporter activity
AA2016_2897	COG1136	(ABC) transporter
AA2016_2897	COG0577	efflux transmembrane transporter activity
AA2016_2899	COG0384	phenazine biosynthesis protein PhzF
AA2016_2901	COG0628	permease
AA2016_2905	COG1959	2 iron, 2 sulfur cluster binding
AA2016_2906	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA2016_2907	COG4208	sulfate ABC transporter
AA2016_2909	COG4150	thiosulfate binding
AA2016_2910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA2016_2911	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA2016_2912	COG1797	cobyrinic acid a,c-diamide synthase activity
AA2016_2914	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AA2016_2927	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_2928	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_2929	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_2930	COG0649	NAD binding
AA2016_2931	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AA2016_2932	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AA2016_2933	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA2016_2933	COG3743	rRNA binding
AA2016_2935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA2016_2936	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_2938	COG0713	ATP synthesis coupled electron transport
AA2016_2941	COG1007	ATP synthesis coupled electron transport
AA2016_2946	COG0442	prolyl-tRNA aminoacylation
AA2016_2948	COG1136	(ABC) transporter
AA2016_2949	COG0442	prolyl-tRNA aminoacylation
AA2016_2951	COG0321	lipoyl(octanoyl) transferase activity
AA2016_2955	COG0789	Transcriptional regulator
AA2016_2956	COG2239	Acts as a magnesium transporter
AA2016_2972	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_2978	COG0583	DNA-binding transcription factor activity
AA2016_2982	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_2982	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_2984	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_2985	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AA2016_2985	COG3264	Mechanosensitive ion channel
AA2016_2990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA2016_3005	COG0583	DNA-binding transcription factor activity
AA2016_3011	COG1410	methionine synthase
AA2016_3011	COG0646	methionine synthase
AA2016_3015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA2016_3016	COG3932	Exopolysaccharide synthesis, ExoD
AA2016_3020	COG5012	cobalamin binding
AA2016_3021	COG5598	trimethylamine methyltransferase
AA2016_3023	COG2186	Transcriptional regulator
AA2016_3024	COG2807	transmembrane transport
AA2016_3026	COG2081	HI0933 family
AA2016_3029	COG2304	oxidoreductase activity
AA2016_3033	COG1410	methionine synthase
AA2016_3033	COG0646	methionine synthase
AA2016_3039	COG0006	proline dipeptidase activity
AA2016_3041	COG5598	trimethylamine methyltransferase
AA2016_3048	COG1960	acyl-CoA dehydrogenase activity
AA2016_3050	COG1492	cobalamin metabolic process
AA2016_3055	COG4172	Belongs to the ABC transporter superfamily
AA2016_3057	COG0601	transmembrane transport
AA2016_3058	COG0747	negative chemotaxis
AA2016_3059	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_3064	COG0243	molybdopterin cofactor binding
AA2016_3065	COG0437	4 iron, 4 sulfur cluster binding
AA2016_3066	COG3302	dmso reductase anchor subunit
AA2016_3067	COG1560	Kdo2-lipid A biosynthetic process
AA2016_3069	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA2016_3070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA2016_3071	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA2016_3077	COG1522	sequence-specific DNA binding
AA2016_3084	COG1629	transport
AA2016_3086	COG3720	iron ion transport
AA2016_3088	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_3089	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA2016_3090	COG1959	2 iron, 2 sulfur cluster binding
AA2016_3093	COG1309	transcriptional regulator
AA2016_3095	COG2733	membrane
AA2016_3104	COG1304	FMN binding
AA2016_3105	COG2832	Protein of unknown function (DUF454)
AA2016_3106	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA2016_3107	COG2205	protein histidine kinase activity
AA2016_3116	COG2205	protein histidine kinase activity
AA2016_3117	COG1525	nuclease
AA2016_3118	COG0625	glutathione transferase activity
AA2016_3119	COG1573	uracil-dna glycosylase
AA2016_3120	COG1522	sequence-specific DNA binding
AA2016_3122	COG2084	Dehydrogenase
AA2016_3126	COG1763	Mo-molybdopterin cofactor biosynthetic process
AA2016_3127	COG0746	molybdenum cofactor guanylyltransferase activity
AA2016_3131	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA2016_3135	COG1846	Transcriptional regulator
AA2016_3136	COG0596	Alpha beta hydrolase
AA2016_3140	COG2989	Protein conserved in bacteria
AA2016_3143	COG0546	phosphoglycolate phosphatase activity
AA2016_3144	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA2016_3147	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA2016_3148	COG2199	diguanylate cyclase activity
AA2016_3149	COG2514	catechol 2,3-dioxygenase activity
AA2016_3151	COG0659	secondary active sulfate transmembrane transporter activity
AA2016_3152	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA2016_3161	COG3608	succinylglutamate desuccinylase aspartoacylase
AA2016_3161	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA2016_3162	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA2016_3169	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_3169	COG0596	Alpha beta hydrolase
AA2016_3178	COG0583	DNA-binding transcription factor activity
AA2016_3179	COG2855	membrane
AA2016_3184	COG0850	regulation of cytokinetic process
AA2016_3185	COG2894	cell division
AA2016_3186	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AA2016_3188	COG2267	carboxylic ester hydrolase activity
AA2016_3194	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_3196	COG1607	acyl-coa hydrolase
AA2016_3197	COG0251	oxidation-reduction process
AA2016_3201	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_3213	COG0045	succinate-CoA ligase (ADP-forming) activity
AA2016_3213	COG1042	CoA-binding domain protein
AA2016_3213	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA2016_3215	COG0459	protein refolding
AA2016_3218	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA2016_3219	COG2235	arginine
AA2016_3225	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA2016_3233	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA2016_3240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_3242	COG0745	RESPONSE REGULATOR receiver
AA2016_3243	COG2205	protein histidine kinase activity
AA2016_3244	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_3247	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA2016_3249	COG0586	Pfam SNARE associated Golgi protein
AA2016_3251	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AA2016_3252	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AA2016_3257	COG5622	Protein required for attachment to host cells
AA2016_3260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA2016_3262	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AA2016_3264	COG1058	Belongs to the CinA family
AA2016_3264	COG1546	Belongs to the CinA family
AA2016_3266	COG0596	Alpha beta hydrolase
AA2016_3269	COG2267	carboxylic ester hydrolase activity
AA2016_3274	COG4191	Histidine kinase
AA2016_3275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA2016_3277	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA2016_3278	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA2016_3281	COG1278	Cold shock
AA2016_3285	COG1024	Enoyl-CoA hydratase
AA2016_3294	COG0516	GMP reductase activity
AA2016_3294	COG0517	IMP dehydrogenase activity
AA2016_3295	COG3811	Belongs to the UPF0386 family
AA2016_3296	COG5002	protein histidine kinase activity
AA2016_3296	COG3850	Histidine kinase
AA2016_3297	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA2016_3299	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA2016_3300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA2016_3305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AA2016_3306	COG0439	Biotin carboxylase
AA2016_3307	COG0511	ligase activity, forming carbon-carbon bonds
AA2016_3308	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA2016_3311	COG0436	Aminotransferase
AA2016_3316	COG2066	Belongs to the glutaminase family
AA2016_3324	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA2016_3327	COG0525	valine-tRNA ligase activity
AA2016_3330	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AA2016_3331	COG0708	Exodeoxyribonuclease III
AA2016_3332	COG2233	PERMEase
AA2016_3336	COG0316	Belongs to the HesB IscA family
AA2016_3337	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AA2016_3338	COG0018	arginyl-trna synthetase
AA2016_3340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AA2016_3341	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA2016_3342	COG3842	ATPase activity
AA2016_3343	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA2016_3344	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA2016_3345	COG0805	protein transport
AA2016_3346	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA2016_3347	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA2016_3348	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA2016_3357	COG0519	Catalyzes the synthesis of GMP from XMP
AA2016_3358	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AA2016_3366	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA2016_3367	COG2003	Belongs to the UPF0758 family
AA2016_3368	COG0024	Methionine aminopeptidase
AA2016_3370	COG2824	Alkylphosphonate utilization operon protein PhnA
AA2016_3372	COG1609	Transcriptional regulator
AA2016_3374	COG1175	transmembrane transport
AA2016_3375	COG0395	ABC-type sugar transport system, permease component
AA2016_3378	COG3842	ATPase activity
AA2016_3382	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA2016_3383	COG1116	anion transmembrane transporter activity
AA2016_3384	COG4149	molybdate abc transporter
AA2016_3386	COG2197	response regulator
AA2016_3389	COG3243	poly(R)-hydroxyalkanoic acid synthase
AA2016_3391	COG0436	Aminotransferase
AA2016_3393	COG1494	fructose-1,6-bisphosphatase
AA2016_3394	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA2016_3395	COG1752	Esterase of the alpha-beta hydrolase superfamily
AA2016_3396	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA2016_3397	COG0302	gtp cyclohydrolase
AA2016_3399	COG0583	DNA-binding transcription factor activity
AA2016_3401	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA2016_3403	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA2016_3406	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_3407	COG2301	Belongs to the HpcH HpaI aldolase family
AA2016_3410	COG0187	DNA topoisomerase II activity
AA2016_3411	COG3706	GGDEF domain
AA2016_3413	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_3413	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_3414	COG0509	glycine decarboxylation via glycine cleavage system
AA2016_3415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_3417	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA2016_3420	COG1671	Belongs to the UPF0178 family
AA2016_3422	COG2153	protein acetylation
AA2016_3423	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA2016_3424	COG0587	DNA-directed DNA polymerase activity
AA2016_3426	COG4941	Belongs to the sigma-70 factor family
AA2016_3427	COG3795	YCII-related domain
AA2016_3430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA2016_3433	COG0475	glutathione-regulated potassium exporter activity
AA2016_3433	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA2016_3436	COG3768	UPF0283 membrane protein
AA2016_3437	COG3106	COG3106 Predicted ATPase
AA2016_3439	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AA2016_3445	COG0513	Belongs to the DEAD box helicase family
AA2016_3447	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3449	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA2016_3450	COG2897	thiosulfate sulfurtransferase activity
AA2016_3453	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA2016_3456	COG0686	Belongs to the AlaDH PNT family
AA2016_3457	COG1522	sequence-specific DNA binding
AA2016_3458	COG0737	Belongs to the 5'-nucleotidase family
AA2016_3460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA2016_3462	COG4957	zinc ion binding
AA2016_3463	COG1530	ribonuclease E activity
AA2016_3464	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA2016_3465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA2016_3470	COG2885	chlorophyll binding
AA2016_3471	COG0513	Belongs to the DEAD box helicase family
AA2016_3472	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA2016_3474	COG3706	GGDEF domain
AA2016_3476	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA2016_3478	COG1414	Transcriptional regulator
AA2016_3479	COG3960	tartronate-semialdehyde synthase activity
AA2016_3480	COG3622	Belongs to the hyi family
AA2016_3481	COG2084	Dehydrogenase
AA2016_3483	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA2016_3484	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA2016_3490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA2016_3491	COG0081	regulation of translation
AA2016_3492	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA2016_3493	COG0222	ribosome binding
AA2016_3494	COG0085	RNA polymerase activity
AA2016_3495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA2016_3497	COG0531	amino acid
AA2016_3499	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AA2016_3500	COG0049	tRNA binding
AA2016_3501	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA2016_3502	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA2016_3503	COG0051	transcription antitermination factor activity, RNA binding
AA2016_3504	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA2016_3505	COG0088	Forms part of the polypeptide exit tunnel
AA2016_3506	COG0089	rRNA binding
AA2016_3507	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA2016_3508	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA2016_3509	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA2016_3510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA2016_3511	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA2016_3512	COG0255	Belongs to the universal ribosomal protein uL29 family
AA2016_3513	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA2016_3514	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA2016_3515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA2016_3516	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AA2016_3517	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA2016_3518	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA2016_3519	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA2016_3520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA2016_3521	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AA2016_3522	COG1841	ribosomal large subunit assembly
AA2016_3523	COG0200	Binds to the 23S rRNA
AA2016_3525	COG0563	adenylate kinase activity
AA2016_3526	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA2016_3527	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA2016_3528	COG0202	RNA polymerase activity
AA2016_3529	COG0203	ribosomal protein L17
AA2016_3531	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA2016_3532	COG0640	Transcriptional regulator
AA2016_3538	COG0321	lipoyl(octanoyl) transferase activity
AA2016_3538	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AA2016_3539	COG0084	hydrolase, TatD family'
AA2016_3542	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA2016_3543	COG1686	Belongs to the peptidase S11 family
AA2016_3553	COG1278	Cold shock
AA2016_3554	COG5490	Phasin protein
AA2016_3555	COG1475	DNA binding
AA2016_3580	COG0708	Exodeoxyribonuclease III
AA2016_3583	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AA2016_3586	COG0583	DNA-binding transcription factor activity
AA2016_3587	COG0601	transmembrane transport
AA2016_3589	COG0444	Belongs to the ABC transporter superfamily
AA2016_3590	COG4608	Belongs to the ABC transporter superfamily
AA2016_3591	COG4166	transmembrane transport
AA2016_3608	COG2885	chlorophyll binding
AA2016_3608	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AA2016_3617	COG3501	Rhs element vgr protein
AA2016_3623	COG0739	heme binding
AA2016_3625	COG0861	Integral membrane protein TerC family
AA2016_3626	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2016_3627	COG2814	Major facilitator Superfamily
AA2016_3634	COG1024	Enoyl-CoA hydratase
AA2016_3636	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3638	COG1960	acyl-CoA dehydrogenase activity
AA2016_3640	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3641	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3644	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3648	COG0183	Belongs to the thiolase family
AA2016_3649	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3651	COG1960	acyl-CoA dehydrogenase activity
AA2016_3654	COG1024	Enoyl-CoA hydratase
AA2016_3654	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_3655	COG0604	alcohol dehydrogenase
AA2016_3656	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3657	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_3659	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3669	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_3670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_3674	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA2016_3676	COG0183	Belongs to the thiolase family
AA2016_3677	COG1960	acyl-CoA dehydrogenase activity
AA2016_3678	COG1960	acyl-CoA dehydrogenase activity
AA2016_3679	COG1024	Enoyl-CoA hydratase
AA2016_3680	COG0667	Aldo Keto reductase
AA2016_3681	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AA2016_3683	COG0410	ABC transporter
AA2016_3685	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_3688	COG2801	Transposase and inactivated derivatives
AA2016_3692	COG1129	ABC transporter
AA2016_3694	COG1183	phosphatidylcholine synthase activity
AA2016_3695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_3696	COG0679	Auxin Efflux Carrier
AA2016_3699	COG4166	transmembrane transport
AA2016_3702	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AA2016_3703	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AA2016_3704	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA2016_3706	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA2016_3707	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA2016_3708	COG0785	Cytochrome C biogenesis protein
AA2016_3713	COG0861	Integral membrane protein TerC family
AA2016_3718	COG2308	Evidence 4 Homologs of previously reported genes of
AA2016_3721	COG0488	(ABC) transporter
AA2016_3725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA2016_3726	COG0343	queuine tRNA-ribosyltransferase activity
AA2016_3727	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AA2016_3729	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA2016_3730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA2016_3731	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA2016_3733	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA2016_3734	COG2095	MarC family integral membrane protein
AA2016_3737	COG0629	single-stranded DNA binding
AA2016_3740	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AA2016_3740	COG1940	carbohydrate kinase activity
AA2016_3741	COG0395	ABC-type sugar transport system, permease component
AA2016_3745	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_3747	COG1794	racemase activity, acting on amino acids and derivatives
AA2016_3748	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA2016_3752	COG1309	transcriptional regulator
AA2016_3753	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3754	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA2016_3754	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA2016_3755	COG0347	Belongs to the P(II) protein family
AA2016_3756	COG0174	glutamine synthetase
AA2016_3758	COG2801	Transposase and inactivated derivatives
AA2016_3763	COG0174	glutamine synthetase
AA2016_3765	COG0697	spore germination
AA2016_3768	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA2016_3769	COG3956	TIGRFAM MazG family protein
AA2016_3770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA2016_3771	COG1923	regulation of RNA biosynthetic process
AA2016_3772	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_3773	COG0569	domain protein
AA2016_3774	COG2204	response regulator
AA2016_3775	COG5000	phosphorelay sensor kinase activity
AA2016_3776	COG2204	response regulator
AA2016_3777	COG3852	Histidine kinase
AA2016_3779	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA2016_3779	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AA2016_3780	COG1546	Belongs to the CinA family
AA2016_3780	COG1058	Belongs to the CinA family
AA2016_3782	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA2016_3784	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA2016_3785	COG0456	acetyltransferase
AA2016_3785	COG1214	PFAM Peptidase M22, glycoprotease
AA2016_3787	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_3788	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_3788	COG0022	dehydrogenase e1 component
AA2016_3789	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA2016_3790	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AA2016_3791	COG0148	phosphopyruvate hydratase activity
AA2016_3794	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AA2016_3797	COG0504	CTP synthase activity
AA2016_3800	COG0149	triose-phosphate isomerase activity
AA2016_3802	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA2016_3803	COG0134	indole-3-glycerol-phosphate synthase activity
AA2016_3804	COG0315	cyclic pyranopterin monophosphate synthase activity
AA2016_3805	COG0303	'Molybdopterin
AA2016_3806	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA2016_3808	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2016_3809	COG0372	Belongs to the citrate synthase family
AA2016_3810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA2016_3812	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA2016_3813	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA2016_3814	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA2016_3815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA2016_3816	COG0750	zinc metalloprotease
AA2016_3817	COG0575	Belongs to the CDS family
AA2016_3818	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA2016_3819	COG0233	cytoplasmic translational termination
AA2016_3820	COG0528	UMP kinase activity
AA2016_3821	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA2016_3822	COG0052	Belongs to the universal ribosomal protein uS2 family
AA2016_3829	COG0537	adenosine 5'-monophosphoramidase activity
AA2016_3835	COG3706	GGDEF domain
AA2016_3837	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA2016_3839	COG1686	Belongs to the peptidase S11 family
AA2016_3840	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA2016_3843	COG1760	l-serine dehydratase
AA2016_3846	COG0154	amidase activity
AA2016_3847	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA2016_3849	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA2016_3850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA2016_3852	COG1960	acyl-CoA dehydrogenase activity
AA2016_3853	COG0540	Belongs to the ATCase OTCase family
AA2016_3854	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA2016_3855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA2016_3856	COG0758	DNA mediated transformation
AA2016_3857	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA2016_3858	COG0557	exoribonuclease II activity
AA2016_3862	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA2016_3863	COG3706	GGDEF domain
AA2016_3863	COG0745	RESPONSE REGULATOR receiver
AA2016_3864	COG0784	Response regulator, receiver
AA2016_3867	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA2016_3868	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA2016_3869	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA2016_3871	COG0492	ferredoxin-NADP+ reductase activity
AA2016_3872	COG0633	Ferredoxin
AA2016_3875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AA2016_3875	COG3218	ABC-type transport auxiliary lipoprotein component
AA2016_3877	COG1127	ABC transporter
AA2016_3879	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_3882	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_3883	COG0280	phosphate acetyltransferase
AA2016_3883	COG0281	malic enzyme
AA2016_3885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2016_3886	COG5265	(ABC) transporter
AA2016_3887	COG0640	Transcriptional regulator
AA2016_3889	COG0740	serine-type endopeptidase activity
AA2016_3897	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AA2016_3898	COG3384	dioxygenase
AA2016_3900	COG0519	Catalyzes the synthesis of GMP from XMP
AA2016_3904	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA2016_3905	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA2016_3906	COG0047	phosphoribosylformylglycinamidine synthase activity
AA2016_3909	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_3910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA2016_3912	COG2226	methyltransferase
AA2016_3914	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA2016_3915	COG2814	Major facilitator Superfamily
AA2016_3916	COG0037	tRNA processing
AA2016_3917	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA2016_3919	COG1733	regulation of RNA biosynthetic process
AA2016_3920	COG0702	epimerase
AA2016_3922	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA2016_3925	COG0538	isocitrate dehydrogenase activity
AA2016_3928	COG0346	lactoylglutathione lyase activity
AA2016_3929	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA2016_3930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA2016_3932	COG2313	pseudouridylate synthase activity
AA2016_3935	COG0316	Belongs to the HesB IscA family
AA2016_3938	COG2151	metal-sulfur cluster biosynthetic enzyme
AA2016_3939	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA2016_3940	COG0719	Fe-S assembly protein
AA2016_3941	COG0396	ATPase activity
AA2016_3943	COG0719	Fe-S assembly protein
AA2016_3945	COG2945	thiolester hydrolase activity
AA2016_3951	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA2016_3953	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA2016_3954	COG0739	heme binding
AA2016_3959	COG0405	Gamma-glutamyltransferase
AA2016_3960	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_3961	COG1129	ABC transporter
AA2016_3966	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_3969	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AA2016_3971	COG0411	ABC transporter
AA2016_3973	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_3977	COG1917	Cupin 2, conserved barrel domain protein
AA2016_3978	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_3980	COG0583	DNA-binding transcription factor activity
AA2016_3983	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_3984	COG0583	DNA-binding transcription factor activity
AA2016_3988	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA2016_3990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA2016_3991	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_3993	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA2016_3994	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA2016_3997	COG4608	Belongs to the ABC transporter superfamily
AA2016_3998	COG0444	Belongs to the ABC transporter superfamily
AA2016_4000	COG0601	transmembrane transport
AA2016_4001	COG1396	sequence-specific DNA binding
AA2016_4002	COG0747	negative chemotaxis
AA2016_4005	COG0776	regulation of translation
AA2016_4007	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA2016_4008	COG0740	serine-type endopeptidase activity
AA2016_4017	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA2016_4018	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA2016_4020	COG0584	glycerophosphoryl diester phosphodiesterase
AA2016_4021	COG0010	Belongs to the arginase family
AA2016_4024	COG1612	heme a metabolic process
AA2016_4030	COG0297	glycogen (starch) synthase activity
AA2016_4037	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA2016_4039	COG0776	regulation of translation
AA2016_4040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA2016_4041	COG0416	fatty acid biosynthetic process
AA2016_4044	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA2016_4045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AA2016_4048	COG1174	glycine betaine transport
AA2016_4049	COG1125	glycine betaine transport
AA2016_4050	COG1174	glycine betaine transport
AA2016_4051	COG1732	Glycine betaine
AA2016_4052	COG2814	Major facilitator Superfamily
AA2016_4053	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA2016_4054	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA2016_4056	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA2016_4056	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA2016_4057	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA2016_4058	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA2016_4060	COG2989	Protein conserved in bacteria
AA2016_4064	COG0113	porphobilinogen synthase activity
AA2016_4066	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AA2016_4068	COG0628	permease
AA2016_4069	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA2016_4071	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA2016_4074	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA2016_4078	COG0477	Major facilitator Superfamily
AA2016_4079	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AA2016_4087	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_4090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA2016_4101	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_4103	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA2016_4107	COG0730	response to heat
AA2016_4109	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_4111	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_4112	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA2016_4113	COG1349	DNA-binding transcription factor activity
AA2016_4116	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA2016_4117	COG0583	DNA-binding transcription factor activity
AA2016_4119	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_4120	COG1116	anion transmembrane transporter activity
AA2016_4120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2016_4121	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2016_4122	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA2016_4123	COG2188	Transcriptional regulator
AA2016_4125	COG1116	anion transmembrane transporter activity
AA2016_4126	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_4128	COG0583	DNA-binding transcription factor activity
AA2016_4129	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_4133	COG1940	carbohydrate kinase activity
AA2016_4133	COG1846	Transcriptional regulator
AA2016_4134	COG1653	transport
AA2016_4140	COG2252	PERMEase
AA2016_4143	COG3842	ATPase activity
AA2016_4145	COG0395	ABC-type sugar transport system, permease component
AA2016_4148	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA2016_4150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA2016_4151	COG1132	(ABC) transporter
AA2016_4152	COG3459	Glycosyltransferase 36 associated
AA2016_4156	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AA2016_4158	COG2986	histidine ammonia-lyase
AA2016_4159	COG1228	amidohydrolase
AA2016_4163	COG0251	oxidation-reduction process
AA2016_4165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA2016_4166	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA2016_4168	COG0523	cobalamin synthesis protein
AA2016_4173	COG1234	tRNA 3'-trailer cleavage
AA2016_4175	COG1063	alcohol dehydrogenase
AA2016_4178	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_4180	COG1960	acyl-CoA dehydrogenase activity
AA2016_4182	COG1902	pentaerythritol trinitrate reductase activity
AA2016_4182	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_4183	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA2016_4186	COG5598	trimethylamine methyltransferase
AA2016_4187	COG0583	DNA-binding transcription factor activity
AA2016_4188	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA2016_4192	COG1663	tetraacyldisaccharide 4'-kinase activity
AA2016_4193	COG1519	Transferase
AA2016_4196	COG0483	inositol monophosphate 1-phosphatase activity
AA2016_4197	COG0312	modulator of DNA gyrase
AA2016_4200	COG0612	Peptidase, M16
AA2016_4201	COG0612	Peptidase, M16
AA2016_4202	COG0742	ribosomal rna small subunit methyltransferase
AA2016_4204	COG0590	tRNA wobble adenosine to inosine editing
AA2016_4206	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA2016_4209	COG0196	riboflavin kinase activity
AA2016_4212	COG2814	Major facilitator Superfamily
AA2016_4214	COG1846	Transcriptional regulator
AA2016_4215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA2016_4215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA2016_4217	COG0459	protein refolding
AA2016_4221	COG3237	CsbD-like
AA2016_4224	COG0114	fumarate hydratase activity
AA2016_4225	COG2259	Doxx family
AA2016_4226	COG2801	Transposase and inactivated derivatives
AA2016_4229	COG0248	Ppx GppA phosphatase
AA2016_4230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA2016_4232	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_4234	COG1126	abc transporter atp-binding protein
AA2016_4235	COG0765	amino acid transport
AA2016_4236	COG4597	amino acid ABC transporter
AA2016_4237	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_4239	COG0626	cystathionine gamma-synthase activity
AA2016_4244	COG3852	Histidine kinase
AA2016_4251	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AA2016_4253	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AA2016_4284	COG0601	transmembrane transport
AA2016_4286	COG0444	Belongs to the ABC transporter superfamily
AA2016_4289	COG2207	Transcriptional regulator
AA2016_4293	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA2016_4295	COG5425	PFAM Usg family protein
AA2016_4297	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_4298	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_4300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AA2016_4302	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA2016_4313	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_4314	COG1129	ABC transporter
AA2016_4317	COG2186	Transcriptional regulator
AA2016_4320	COG2186	Transcriptional regulator
AA2016_4321	COG1136	(ABC) transporter
AA2016_4341	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_4344	COG3265	gluconokinase activity
AA2016_4345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2016_4347	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA2016_4348	COG2084	Dehydrogenase
AA2016_4363	COG0444	Belongs to the ABC transporter superfamily
AA2016_4364	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_4367	COG0747	negative chemotaxis
AA2016_4368	COG2186	Transcriptional regulator
AA2016_4369	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AA2016_4373	COG3474	cytochrome
AA2016_4395	COG0210	DNA helicase
AA2016_4403	COG0640	Transcriptional regulator
AA2016_4404	COG0798	PFAM Bile acid sodium symporter
AA2016_4406	COG0431	NADPH-dependent FMN reductase
AA2016_4410	COG0753	catalase activity
AA2016_4417	COG1278	Cold shock
AA2016_4419	COG3685	Protein conserved in bacteria
AA2016_4421	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_4430	COG2827	Endonuclease containing a URI domain
AA2016_4437	COG2827	Endonuclease containing a URI domain
AA2016_4438	COG0784	Response regulator, receiver
AA2016_4438	COG2205	protein histidine kinase activity
AA2016_4438	COG2198	Histidine kinase
AA2016_4439	COG2197	response regulator
AA2016_4440	COG1280	lysine exporter protein (LysE YggA)
AA2016_4443	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_4445	COG0747	negative chemotaxis
AA2016_4453	COG0628	permease
AA2016_4454	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AA2016_4455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA2016_4456	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA2016_4464	COG0583	DNA-binding transcription factor activity
AA2016_4474	COG0583	DNA-binding transcription factor activity
AA2016_4475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_4476	COG0765	amino acid transport
AA2016_4478	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AA2016_4481	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA2016_4488	COG0243	molybdopterin cofactor binding
AA2016_4489	COG0488	(ABC) transporter
AA2016_4490	COG2211	Major facilitator Superfamily
AA2016_4494	COG0105	UTP biosynthetic process
AA2016_4497	COG0314	molybdopterin synthase activity
AA2016_4500	COG0322	excinuclease ABC activity
AA2016_4512	COG0625	glutathione transferase activity
AA2016_4515	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AA2016_4523	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA2016_4528	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA2016_4529	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA2016_4530	COG0194	GDP metabolic process
AA2016_4531	COG1561	YicC-like family, N-terminal region
AA2016_4532	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AA2016_4533	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA2016_4534	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA2016_4536	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA2016_4537	COG1368	sulfuric ester hydrolase activity
AA2016_4538	COG0360	Binds together with S18 to 16S ribosomal RNA
AA2016_4540	COG0359	binds to the 23S rRNA
AA2016_4541	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA2016_4542	COG1742	UPF0060 membrane protein
AA2016_4543	COG3468	outer membrane autotransporter barrel domain protein
AA2016_4544	COG0305	Participates in initiation and elongation during chromosome replication
AA2016_4547	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA2016_4549	COG4221	oxidoreductase activity
AA2016_4550	COG0471	metal ion transport
AA2016_4550	COG3273	potassium ion transport
AA2016_4556	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_4556	COG0204	Acyl-transferase
AA2016_4558	COG0688	phosphatidylethanolamine metabolic process
AA2016_4559	COG5265	(ABC) transporter
AA2016_4561	COG1652	LysM domain
AA2016_4564	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA2016_4570	COG2852	Protein conserved in bacteria
AA2016_4571	COG0215	cysteine-tRNA ligase activity
AA2016_4575	COG0494	nUDIX hydrolase
AA2016_4579	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA2016_4581	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AA2016_4586	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_4588	COG0640	Transcriptional regulator
AA2016_4589	COG0189	ligase activity
AA2016_4595	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
AA2016_4600	COG1381	Involved in DNA repair and RecF pathway recombination
AA2016_4601	COG0477	Major facilitator Superfamily
AA2016_4605	COG2814	Major facilitator Superfamily
AA2016_4609	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_4615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_4617	COG1280	lysine exporter protein (LysE YggA)
AA2016_4621	COG2814	Major facilitator Superfamily
AA2016_4624	COG0300	oxidoreductase activity
AA2016_4627	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA2016_4628	COG0571	ribonuclease III activity
AA2016_4629	COG0681	Belongs to the peptidase S26 family
AA2016_4630	COG0736	holo-[acyl-carrier-protein] synthase activity
AA2016_4631	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA2016_4633	COG1758	RNA polymerase activity
AA2016_4637	COG2827	Endonuclease containing a URI domain
AA2016_4638	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA2016_4639	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_4640	COG0741	lytic transglycosylase activity
AA2016_4644	COG4974	Belongs to the 'phage' integrase family
AA2016_4647	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
AA2016_4648	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA2016_4650	COG1960	acyl-CoA dehydrogenase activity
AA2016_4654	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA2016_4657	COG0450	alkyl hydroperoxide reductase
AA2016_4661	COG0625	glutathione transferase activity
AA2016_4664	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA2016_4670	COG1573	uracil-dna glycosylase
AA2016_4673	COG0438	transferase activity, transferring glycosyl groups
AA2016_4676	COG0308	aminopeptidase N
AA2016_4677	COG2202	Pas domain
AA2016_4677	COG2205	protein histidine kinase activity
AA2016_4678	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_4680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AA2016_4681	COG2205	protein histidine kinase activity
AA2016_4682	COG0745	RESPONSE REGULATOR receiver
AA2016_4683	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA2016_4684	COG3088	subunit of a heme lyase
AA2016_4685	COG1138	Cytochrome C-type biogenesis protein
AA2016_4686	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AA2016_4687	COG4235	cytochrome complex assembly
AA2016_4690	COG0745	RESPONSE REGULATOR receiver
AA2016_4692	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA2016_4699	COG2205	protein histidine kinase activity
AA2016_4701	COG2166	iron-sulfur cluster assembly
AA2016_4702	COG4957	zinc ion binding
AA2016_4703	COG1320	monovalent cation:proton antiporter activity
AA2016_4704	COG2212	antiporter activity
AA2016_4707	COG1006	Multisubunit Na H antiporter MnhC subunit
AA2016_4708	COG2111	Na H antiporter
AA2016_4712	COG2010	Cytochrome c
AA2016_4713	COG3909	cytochrome
AA2016_4714	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA2016_4715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_4717	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_4718	COG0433	COG0433 Predicted ATPase
AA2016_4719	COG2336	PFAM SpoVT AbrB
AA2016_4720	COG3654	unkown
AA2016_4721	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2016_4723	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_4724	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA2016_4725	COG1309	transcriptional regulator
AA2016_4726	COG3119	arylsulfatase activity
AA2016_4728	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AA2016_4729	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_4731	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA2016_4734	COG4172	Belongs to the ABC transporter superfamily
AA2016_4735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_4736	COG0601	transmembrane transport
AA2016_4738	COG0366	Alpha amylase catalytic
AA2016_4739	COG1523	belongs to the glycosyl hydrolase 13 family
AA2016_4740	COG0033	Phosphoglucomutase
AA2016_4741	COG0297	glycogen (starch) synthase activity
AA2016_4742	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA2016_4743	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA2016_4744	COG0058	SHG alpha-glucan phosphorylase activity
AA2016_4752	COG1218	3'(2'),5'-bisphosphate nucleotidase
AA2016_4754	COG0175	sulfate reduction
AA2016_4763	COG3685	Protein conserved in bacteria
AA2016_4770	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_4773	COG0574	Belongs to the PEP-utilizing enzyme family
AA2016_4773	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA2016_4776	COG0583	DNA-binding transcription factor activity
AA2016_4777	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_4778	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2016_4782	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_4785	COG0183	Belongs to the thiolase family
AA2016_4787	COG0454	-acetyltransferase
AA2016_4788	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AA2016_4790	COG4172	Belongs to the ABC transporter superfamily
AA2016_4793	COG0747	negative chemotaxis
AA2016_4794	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA2016_4795	COG2971	BadF BadG BcrA BcrD
AA2016_4796	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA2016_4797	COG1737	Transcriptional regulator
AA2016_4798	COG0243	molybdopterin cofactor binding
AA2016_4800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA2016_4802	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2016_4803	COG3707	response regulator
AA2016_4804	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA2016_4805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA2016_4808	COG1196	nuclear chromosome segregation
AA2016_4811	COG1194	a g-specific adenine glycosylase
AA2016_4812	COG1011	Hydrolase
AA2016_4813	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AA2016_4814	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_4818	COG0583	DNA-binding transcription factor activity
AA2016_4819	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA2016_4822	COG0612	Peptidase, M16
AA2016_4823	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA2016_4825	COG1678	Uncharacterized ACR, COG1678
AA2016_4827	COG0678	peroxiredoxin activity
AA2016_4828	COG0328	RNA-DNA hybrid ribonuclease activity
AA2016_4829	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA2016_4830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA2016_4831	COG3346	SURF1 family
AA2016_4835	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AA2016_4837	COG0109	protoheme IX farnesyltransferase activity
AA2016_4838	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA2016_4839	COG1565	acr, cog1565
AA2016_4839	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA2016_4841	COG0312	modulator of DNA gyrase
AA2016_4842	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA2016_4843	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA2016_4845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA2016_4846	COG1741	Belongs to the pirin family
AA2016_4849	COG1733	regulation of RNA biosynthetic process
AA2016_4850	COG1722	exodeoxyribonuclease VII activity
AA2016_4851	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA2016_4852	COG1309	transcriptional regulator
AA2016_4857	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AA2016_4859	COG0406	alpha-ribazole phosphatase activity
AA2016_4860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA2016_4861	COG0484	heat shock protein binding
AA2016_4863	COG0259	pyridoxamine-phosphate oxidase activity
AA2016_4864	COG1024	Enoyl-CoA hydratase
AA2016_4865	COG1960	acyl-CoA dehydrogenase activity
AA2016_4868	COG0151	Belongs to the GarS family
AA2016_4872	COG0009	L-threonylcarbamoyladenylate synthase
AA2016_4875	COG0751	glycine-tRNA ligase activity
AA2016_4877	COG0752	glycyl-tRNA synthetase alpha subunit
AA2016_4879	COG0142	geranyltranstransferase activity
AA2016_4884	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AA2016_4885	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA2016_4888	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA2016_4890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA2016_4891	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA2016_4892	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA2016_4893	COG0356	it plays a direct role in the translocation of protons across the membrane
AA2016_4896	COG1160	GTP binding
AA2016_4900	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AA2016_4901	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AA2016_4903	COG0583	DNA-binding transcription factor activity
AA2016_4904	COG1393	Belongs to the ArsC family
AA2016_4905	COG0251	oxidation-reduction process
AA2016_4907	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_4911	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_4913	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_4916	COG0494	nUDIX hydrolase
AA2016_4917	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_4921	COG0477	Major facilitator Superfamily
AA2016_4922	COG0583	DNA-binding transcription factor activity
AA2016_4923	COG0242	peptide deformylase activity
AA2016_4927	COG4172	Belongs to the ABC transporter superfamily
AA2016_4928	COG0444	Belongs to the ABC transporter superfamily
AA2016_4929	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_4938	COG0840	transmembrane signaling receptor activity
AA2016_4939	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_4941	COG3386	PFAM SMP-30 Gluconolaconase
AA2016_4942	COG0800	Aldolase
AA2016_4943	COG3734	2-keto-3-deoxy-galactonokinase
AA2016_4944	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_4945	COG2017	converts alpha-aldose to the beta-anomer
AA2016_4947	COG1129	ABC transporter
AA2016_4949	COG2186	Transcriptional regulator
AA2016_4950	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_4958	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA2016_4959	COG0163	prenyltransferase activity
AA2016_4963	COG0523	cobalamin synthesis protein
AA2016_4964	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA2016_4967	COG2233	PERMEase
AA2016_4968	COG0583	DNA-binding transcription factor activity
AA2016_4971	COG0431	NADPH-dependent FMN reductase
AA2016_4974	COG0477	Major facilitator Superfamily
AA2016_4978	COG3177	Filamentation induced by cAMP protein fic
AA2016_4980	COG1126	abc transporter atp-binding protein
AA2016_4981	COG1959	2 iron, 2 sulfur cluster binding
AA2016_4982	COG2346	COG2346, Truncated hemoglobins
AA2016_4988	COG3278	Belongs to the heme-copper respiratory oxidase family
AA2016_4991	COG2010	Cytochrome c
AA2016_4999	COG0583	DNA-binding transcription factor activity
AA2016_5006	COG1484	DNA-dependent DNA replication
AA2016_5007	COG4584	PFAM Integrase catalytic
AA2016_5012	COG1525	nuclease
AA2016_5014	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_5018	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA2016_5022	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA2016_5023	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA2016_5029	COG2151	metal-sulfur cluster biosynthetic enzyme
AA2016_5042	COG3794	PFAM blue (type 1) copper domain protein
AA2016_5046	COG2814	Major facilitator Superfamily
AA2016_5049	COG3005	denitrification pathway
AA2016_5053	COG4459	periplasmic nitrate reductase
AA2016_5054	COG1959	2 iron, 2 sulfur cluster binding
AA2016_5060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2016_5063	COG0714	Associated with various cellular activities
AA2016_5064	COG3256	nitric oxide reductase
AA2016_5067	COG1845	cytochrome c oxidase, subunit III
AA2016_5069	COG3706	GGDEF domain
AA2016_5071	COG4521	taurine ABC transporter
AA2016_5078	COG5489	Protein of unknown function (DUF736)
AA2016_5080	COG2197	response regulator
AA2016_5081	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA2016_5086	COG4957	zinc ion binding
AA2016_5093	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_5094	COG0765	amino acid transport
AA2016_5095	COG0765	amino acid transport
AA2016_5096	COG1126	abc transporter atp-binding protein
AA2016_5097	COG3608	succinylglutamate desuccinylase aspartoacylase
AA2016_5105	COG0741	lytic transglycosylase activity
AA2016_5106	COG2433	Pfam Transposase IS66
AA2016_5107	COG3436	PFAM IS66 Orf2 family protein
AA2016_5112	COG1522	sequence-specific DNA binding
AA2016_5114	COG4962	Type ii secretion system protein e
AA2016_5115	COG3838	Conjugal transfer protein Trbc
AA2016_5117	COG3451	type IV secretory pathway VirB4
AA2016_5120	COG3846	protein secretion by the type IV secretion system
AA2016_5123	COG2948	multi-organism process
AA2016_5126	COG3550	peptidyl-serine autophosphorylation
AA2016_5127	COG1396	sequence-specific DNA binding
AA2016_5134	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AA2016_5135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA2016_5135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA2016_5136	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AA2016_5137	COG0583	DNA-binding transcription factor activity
AA2016_5138	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA2016_5139	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AA2016_5140	COG0124	histidyl-tRNA synthetase
AA2016_5143	COG2818	Glycosylase
AA2016_5144	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_5145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA2016_5146	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_5146	COG1388	LysM domain
AA2016_5148	COG0247	lactate metabolic process
AA2016_5151	COG2852	Protein conserved in bacteria
AA2016_5153	COG0277	FAD linked oxidase domain protein
AA2016_5155	COG2186	Transcriptional regulator
AA2016_5156	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA2016_5169	COG0583	DNA-binding transcription factor activity
AA2016_5170	COG1570	exodeoxyribonuclease VII activity
AA2016_5172	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2016_5173	COG1178	ABC-type Fe3 transport system permease component
AA2016_5174	COG1840	ABC-type Fe3 transport system, periplasmic component
AA2016_5175	COG2205	protein histidine kinase activity
AA2016_5176	COG5490	Phasin protein
AA2016_5180	COG1177	transmembrane transport
AA2016_5181	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_5182	COG3842	ATPase activity
AA2016_5186	COG2814	Major facilitator Superfamily
AA2016_5188	COG3300	MHYT domain
AA2016_5188	COG5001	Diguanylate cyclase
AA2016_5190	COG2224	Isocitrate lyase
AA2016_5194	COG0174	glutamine synthetase
AA2016_5195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_5196	COG0642	Histidine kinase
AA2016_5197	COG0745	RESPONSE REGULATOR receiver
AA2016_5201	COG1595	DNA-templated transcription, initiation
AA2016_5206	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA2016_5207	COG0363	glucosamine-6-phosphate deaminase activity
AA2016_5208	COG0129	dihydroxy-acid dehydratase activity
AA2016_5210	COG0488	(ABC) transporter
AA2016_5213	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA2016_5217	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AA2016_5224	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AA2016_5225	COG4149	molybdate abc transporter
AA2016_5226	COG0725	ABC transporter, periplasmic molybdate-binding protein
AA2016_5227	COG0730	response to heat
AA2016_5228	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AA2016_5229	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AA2016_5231	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA2016_5236	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA2016_5239	COG5328	Belongs to the UPF0262 family
AA2016_5241	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA2016_5242	COG0424	maF-like protein
AA2016_5243	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AA2016_5245	COG0577	efflux transmembrane transporter activity
AA2016_5245	COG1136	(ABC) transporter
AA2016_5246	COG1136	(ABC) transporter
AA2016_5250	COG5001	Diguanylate cyclase
AA2016_5250	COG3300	MHYT domain
AA2016_5253	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_5254	COG2186	Transcriptional regulator
AA2016_5260	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AA2016_5261	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_5269	COG0251	oxidation-reduction process
AA2016_5271	COG0765	amino acid transport
AA2016_5272	COG0765	amino acid transport
AA2016_5278	COG1120	ATPase activity
AA2016_5279	COG3585	molybdate ion transport
AA2016_5280	COG1720	tRNA m6t6A37 methyltransferase activity
AA2016_5283	COG4215	(ABC) transporter
AA2016_5285	COG3457	Alanine racemase
AA2016_5286	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_5288	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_5290	COG1970	mechanosensitive ion channel activity
AA2016_5291	COG0784	Response regulator, receiver
AA2016_5291	COG2198	Histidine kinase
AA2016_5291	COG2205	protein histidine kinase activity
AA2016_5295	COG0167	dihydroorotate dehydrogenase activity
AA2016_5297	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA2016_5299	COG5001	Diguanylate cyclase
AA2016_5301	COG0463	Glycosyl transferase, family 2
AA2016_5303	COG0717	Belongs to the dCTP deaminase family
AA2016_5305	COG2967	ApaG domain
AA2016_5306	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA2016_5307	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA2016_5308	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA2016_5310	COG0598	Magnesium transport protein CorA
AA2016_5311	COG0704	Plays a role in the regulation of phosphate uptake
AA2016_5313	COG0640	Transcriptional regulator
AA2016_5314	COG5002	protein histidine kinase activity
AA2016_5315	COG2326	polyphosphate kinase activity
AA2016_5316	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_5318	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AA2016_5324	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_5324	COG1024	Enoyl-CoA hydratase
AA2016_5325	COG0183	Belongs to the thiolase family
AA2016_5326	COG1960	acyl-CoA dehydrogenase activity
AA2016_5327	COG1960	acyl-CoA dehydrogenase activity
AA2016_5329	COG0730	response to heat
AA2016_5331	COG0789	Transcriptional regulator
AA2016_5333	COG1201	RNA secondary structure unwinding
AA2016_5337	COG1793	dna ligase
AA2016_5349	COG3422	double-strand break repair
AA2016_5352	COG0444	Belongs to the ABC transporter superfamily
AA2016_5353	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_5355	COG0747	negative chemotaxis
AA2016_5356	COG4608	Belongs to the ABC transporter superfamily
AA2016_5357	COG0444	Belongs to the ABC transporter superfamily
AA2016_5358	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_5359	COG0601	transmembrane transport
AA2016_5360	COG0747	negative chemotaxis
AA2016_5361	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_5363	COG0024	Methionine aminopeptidase
AA2016_5367	COG2226	methyltransferase
AA2016_5368	COG0129	dihydroxy-acid dehydratase activity
AA2016_5382	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_5383	COG0166	Belongs to the GPI family
AA2016_5386	COG0489	protein tyrosine kinase activity
AA2016_5391	COG0583	DNA-binding transcription factor activity
AA2016_5394	COG3383	formate dehydrogenase (NAD+) activity
AA2016_5395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA2016_5397	COG2197	response regulator
AA2016_5404	COG5002	protein histidine kinase activity
AA2016_5405	COG1349	DNA-binding transcription factor activity
AA2016_5407	COG0517	IMP dehydrogenase activity
AA2016_5407	COG4175	Glycine betaine
AA2016_5408	COG4176	ABC-type proline glycine betaine transport system permease component
AA2016_5411	COG2340	Cysteine-rich secretory protein family
AA2016_5412	COG0697	spore germination
AA2016_5414	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_5416	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_5419	COG1132	(ABC) transporter
AA2016_5420	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_5421	COG0288	reversible hydration of carbon dioxide
AA2016_5425	COG5002	protein histidine kinase activity
AA2016_5426	COG0594	ribonuclease P activity
AA2016_5427	COG0706	membrane insertase activity
AA2016_5429	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AA2016_5431	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_5432	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA2016_5435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA2016_5438	COG3186	Phenylalanine-4-hydroxylase
AA2016_5440	COG0477	Major facilitator Superfamily
AA2016_5441	COG3706	GGDEF domain
AA2016_5445	COG2171	N-acyltransferase activity
AA2016_5447	COG3152	Membrane
AA2016_5450	COG3706	GGDEF domain
AA2016_5451	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_5455	COG0101	tRNA pseudouridine synthase activity
AA2016_5457	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA2016_5458	COG0242	peptide deformylase activity
AA2016_5466	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_5468	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA2016_5469	COG3773	Cell wall hydrolase
AA2016_5469	COG3409	Peptidoglycan-binding domain 1 protein
AA2016_5470	COG1063	alcohol dehydrogenase
AA2016_5471	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA2016_5472	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA2016_5475	COG2816	NAD+ diphosphatase activity
AA2016_5476	COG2226	methyltransferase
AA2016_5477	COG0077	Prephenate dehydratase
AA2016_5477	COG1605	Chorismate mutase
AA2016_5478	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AA2016_5479	COG3474	cytochrome
AA2016_5480	COG4166	transmembrane transport
AA2016_5481	COG4166	transmembrane transport
AA2016_5482	COG4174	ABC transporter (Permease)
AA2016_5483	COG4239	(ABC) transporter, permease
AA2016_5484	COG4172	Belongs to the ABC transporter superfamily
AA2016_5486	COG0791	NLP P60 protein
AA2016_5488	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA2016_5495	COG4964	Belongs to the GSP D family
AA2016_5502	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AA2016_5503	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA2016_5504	COG1024	Enoyl-CoA hydratase
AA2016_5505	COG0268	Binds directly to 16S ribosomal RNA
AA2016_5506	COG1192	Involved in chromosome partitioning
AA2016_5507	COG1475	DNA binding
AA2016_5508	COG1414	Transcriptional regulator
AA2016_5510	COG0500	methyltransferase
AA2016_5511	COG2390	Transcriptional regulator
AA2016_5512	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_5512	COG3347	Dehydrogenase
AA2016_5515	COG1129	ABC transporter
AA2016_5516	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_5517	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_5520	COG1070	Carbohydrate kinase
AA2016_5522	COG4952	isomerase
AA2016_5523	COG3254	rhamnose metabolic process
AA2016_5524	COG0235	Class ii aldolase
AA2016_5526	COG0395	ABC-type sugar transport system, permease component
AA2016_5527	COG1175	transmembrane transport
AA2016_5529	COG1940	carbohydrate kinase activity
AA2016_5529	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AA2016_5531	COG2188	Transcriptional regulator
AA2016_5532	COG0410	ABC transporter
AA2016_5533	COG0411	ABC transporter
AA2016_5535	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_5537	COG0300	oxidoreductase activity
AA2016_5540	COG1595	DNA-templated transcription, initiation
AA2016_5541	COG3806	Anti-sigma factor
AA2016_5543	COG0583	DNA-binding transcription factor activity
AA2016_5544	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_5548	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AA2016_5550	COG4176	ABC-type proline glycine betaine transport system permease component
AA2016_5551	COG4175	Glycine betaine
AA2016_5551	COG0517	IMP dehydrogenase activity
AA2016_5552	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AA2016_5554	COG1940	carbohydrate kinase activity
AA2016_5555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_5558	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_5560	COG1129	ABC transporter
AA2016_5561	COG0583	DNA-binding transcription factor activity
AA2016_5562	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA2016_5563	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2016_5564	COG1840	ABC-type Fe3 transport system, periplasmic component
AA2016_5566	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_5567	COG1177	transmembrane transport
AA2016_5569	COG0747	negative chemotaxis
AA2016_5570	COG0601	transmembrane transport
AA2016_5572	COG3964	amidohydrolase
AA2016_5575	COG1921	L-seryl-tRNASec selenium transferase activity
AA2016_5581	COG5001	Diguanylate cyclase
AA2016_5583	COG0720	synthase
AA2016_5584	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_5586	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_5593	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_5600	COG1126	abc transporter atp-binding protein
AA2016_5602	COG0830	nickel cation binding
AA2016_5603	COG0831	urea catabolic process
AA2016_5603	COG0832	Belongs to the urease beta subunit family
AA2016_5604	COG0804	urea catabolic process
AA2016_5605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA2016_5606	COG0829	nickel cation binding
AA2016_5610	COG2855	membrane
AA2016_5611	COG0028	Belongs to the TPP enzyme family
AA2016_5614	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_5615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AA2016_5616	COG4521	taurine ABC transporter
AA2016_5617	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_5619	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_5621	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_5623	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2016_5626	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA2016_5629	COG1942	4-Oxalocrotonate Tautomerase
AA2016_5631	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_5634	COG0523	cobalamin synthesis protein
AA2016_5636	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_5637	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AA2016_5638	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AA2016_5639	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AA2016_5640	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AA2016_5645	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_5647	COG1022	Amp-dependent synthetase and ligase
AA2016_5654	COG0028	Belongs to the TPP enzyme family
AA2016_5655	COG1448	Aminotransferase
AA2016_5657	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2016_5658	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2016_5658	COG0473	3-isopropylmalate dehydrogenase activity
AA2016_5660	COG3384	dioxygenase
AA2016_5661	COG2159	amidohydrolase
AA2016_5667	COG2186	Transcriptional regulator
AA2016_5669	COG0601	transmembrane transport
AA2016_5670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_5672	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_5674	COG3971	2-oxopent-4-enoate hydratase activity
AA2016_5675	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2016_5679	COG1846	Transcriptional regulator
AA2016_5683	COG0006	proline dipeptidase activity
AA2016_5684	COG4608	Belongs to the ABC transporter superfamily
AA2016_5685	COG0444	Belongs to the ABC transporter superfamily
AA2016_5687	COG0601	transmembrane transport
AA2016_5688	COG0747	negative chemotaxis
AA2016_5689	COG1476	TRANSCRIPTIONal
AA2016_5690	COG3938	Belongs to the proline racemase family
AA2016_5691	COG1802	Transcriptional regulator
AA2016_5692	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AA2016_5694	COG4191	Histidine kinase
AA2016_5696	COG1126	abc transporter atp-binding protein
AA2016_5697	COG0765	amino acid transport
AA2016_5698	COG0765	amino acid transport
AA2016_5699	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_5700	COG0527	aspartate kinase activity
AA2016_5701	COG5285	phytanoyl-CoA dioxygenase
AA2016_5702	COG1917	Cupin 2, conserved barrel domain protein
AA2016_5703	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_5708	COG4149	molybdate abc transporter
AA2016_5709	COG3842	ATPase activity
AA2016_5710	COG0406	alpha-ribazole phosphatase activity
AA2016_5711	COG1522	sequence-specific DNA binding
AA2016_5713	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_5713	COG3453	Protein conserved in bacteria
AA2016_5714	COG3453	Protein conserved in bacteria
AA2016_5714	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_5717	COG1940	carbohydrate kinase activity
AA2016_5718	COG2182	Extracellular solute-binding protein
AA2016_5720	COG0395	ABC-type sugar transport system, permease component
AA2016_5721	COG0165	Argininosuccinate lyase
AA2016_5723	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_5724	COG0183	Belongs to the thiolase family
AA2016_5725	COG1024	Enoyl-CoA hydratase
AA2016_5725	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_5728	COG1960	acyl-CoA dehydrogenase activity
AA2016_5729	COG1024	Enoyl-CoA hydratase
AA2016_5732	COG1335	isochorismatase
AA2016_5733	COG4977	sequence-specific DNA binding
AA2016_5735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA2016_5736	COG1802	Transcriptional regulator
AA2016_5739	COG1122	ATPase activity
AA2016_5740	COG4120	Belongs to the binding-protein-dependent transport system permease family
AA2016_5743	COG0411	ABC transporter
AA2016_5745	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_5747	COG3483	tryptophan 2,3-dioxygenase activity
AA2016_5750	COG4206	TonB-dependent receptor
AA2016_5752	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_5753	COG1120	ATPase activity
AA2016_5759	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA2016_5761	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA2016_5762	COG2986	histidine ammonia-lyase
AA2016_5763	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_5766	COG1294	oxidase, subunit
AA2016_5767	COG1271	oxidase subunit
AA2016_5780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA2016_5782	COG1957	nucleoside hydrolase
AA2016_5783	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_5787	COG0045	succinate-CoA ligase (ADP-forming) activity
AA2016_5788	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AA2016_5789	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2016_5790	COG2379	hydroxypyruvate reductase
AA2016_5795	COG1216	Glycosyl transferase, family 2
AA2016_5804	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA2016_5805	COG2218	PFAM glutamate synthase alpha subunit domain protein
AA2016_5806	COG0069	glutamate synthase activity
AA2016_5808	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_5810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_5810	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_5813	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AA2016_5814	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA2016_5825	COG0531	amino acid
AA2016_5832	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AA2016_5834	COG0625	glutathione transferase activity
AA2016_5836	COG3842	ATPase activity
AA2016_5837	COG1840	ABC-type Fe3 transport system, periplasmic component
AA2016_5839	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_5841	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_5843	COG3842	ATPase activity
AA2016_5847	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_5849	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA2016_5851	COG0583	DNA-binding transcription factor activity
AA2016_5853	COG3795	YCII-related domain
AA2016_5856	COG2076	Multidrug Resistance protein
AA2016_5859	COG1349	DNA-binding transcription factor activity
AA2016_5863	COG1942	4-Oxalocrotonate Tautomerase
AA2016_5864	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2016_5865	COG0583	DNA-binding transcription factor activity
AA2016_5866	COG0747	negative chemotaxis
AA2016_5869	COG0601	transmembrane transport
AA2016_5871	COG4608	Belongs to the ABC transporter superfamily
AA2016_5872	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_5878	COG1414	Transcriptional regulator
AA2016_5879	COG0747	negative chemotaxis
AA2016_5880	COG0667	Aldo Keto reductase
AA2016_5881	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_5884	COG0444	Belongs to the ABC transporter superfamily
AA2016_5885	COG4608	Belongs to the ABC transporter superfamily
AA2016_5886	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_5892	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_5893	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_5896	COG1013	pyruvate-flavodoxin oxidoreductase activity
AA2016_5902	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_5904	COG0741	lytic transglycosylase activity
AA2016_5904	COG1196	nuclear chromosome segregation
AA2016_5904	COG0739	heme binding
AA2016_5917	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2016_5919	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA2016_5920	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_5920	COG0022	dehydrogenase e1 component
AA2016_5921	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_5924	COG3842	ATPase activity
AA2016_5925	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_5926	COG1177	transmembrane transport
AA2016_5928	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_5932	COG3732	PTS system glucitol sorbitol-specific
AA2016_5934	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA2016_5936	COG2390	Transcriptional regulator
AA2016_5939	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA2016_5941	COG3842	ATPase activity
AA2016_5942	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA2016_5943	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA2016_5947	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_5948	COG0747	negative chemotaxis
AA2016_5957	COG5001	Diguanylate cyclase
AA2016_5958	COG1674	ftsk spoiiie
AA2016_5971	COG0765	amino acid transport
AA2016_5973	COG4208	sulfate ABC transporter
AA2016_5974	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_5979	COG1024	Enoyl-CoA hydratase
AA2016_5980	COG0604	alcohol dehydrogenase
AA2016_5982	COG0277	FAD linked oxidase domain protein
AA2016_5985	COG1192	Involved in chromosome partitioning
AA2016_5986	COG1475	DNA binding
AA2016_5987	COG1414	Transcriptional regulator
AA2016_5992	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_5996	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_5998	COG1309	transcriptional regulator
AA2016_6000	COG1960	acyl-CoA dehydrogenase activity
AA2016_6002	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_6003	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA2016_6004	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2016_6006	COG1802	Transcriptional regulator
AA2016_6011	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_6020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_6022	COG3842	ATPase activity
AA2016_6023	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_6026	COG2801	Transposase and inactivated derivatives
AA2016_6028	COG2801	Transposase and inactivated derivatives
AA2016_6034	COG2171	N-acyltransferase activity
AA2016_6041	COG2084	Dehydrogenase
AA2016_6042	COG3622	Belongs to the hyi family
AA2016_6043	COG0235	Class ii aldolase
AA2016_6044	COG3395	kinase activity
AA2016_6045	COG2084	Dehydrogenase
AA2016_6047	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_6050	COG0601	transmembrane transport
AA2016_6052	COG0444	Belongs to the ABC transporter superfamily
AA2016_6053	COG4608	Belongs to the ABC transporter superfamily
AA2016_6054	COG2801	Transposase and inactivated derivatives
AA2016_6057	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_6060	COG0395	ABC-type sugar transport system, permease component
AA2016_6061	COG1175	transmembrane transport
AA2016_6065	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AA2016_6070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA2016_6072	COG3273	potassium ion transport
AA2016_6072	COG0471	metal ion transport
AA2016_6073	COG1845	cytochrome c oxidase, subunit III
AA2016_6076	COG3256	nitric oxide reductase
AA2016_6077	COG0714	Associated with various cellular activities
AA2016_6081	COG3550	peptidyl-serine autophosphorylation
AA2016_6082	COG0420	3'-5' exonuclease activity
AA2016_6083	COG4717	serine-type aminopeptidase activity
AA2016_6084	COG0655	NAD(P)H dehydrogenase (quinone) activity
AA2016_6087	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA2016_6089	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2016_6095	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2016_6102	COG1522	sequence-specific DNA binding
AA2016_6104	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_6105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA2016_6112	COG0471	metal ion transport
AA2016_6112	COG0490	domain, Protein
AA2016_6113	COG4974	Belongs to the 'phage' integrase family
AA2016_6114	COG0582	viral genome integration into host DNA
AA2016_6115	COG4974	Belongs to the 'phage' integrase family
AA2016_6119	COG5489	Protein of unknown function (DUF736)
AA2016_6120	COG3831	ATPase activity
AA2016_6132	COG0444	Belongs to the ABC transporter superfamily
AA2016_6133	COG4608	Belongs to the ABC transporter superfamily
AA2016_6135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_6136	COG0601	transmembrane transport
AA2016_6137	COG0747	negative chemotaxis
AA2016_6139	COG2801	Transposase and inactivated derivatives
AA2016_6140	COG2801	Transposase and inactivated derivatives
AA2016_6142	COG0450	alkyl hydroperoxide reductase
AA2016_6143	COG0251	oxidation-reduction process
AA2016_6144	COG0626	cystathionine gamma-synthase activity
AA2016_6146	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_6147	COG0765	amino acid transport
AA2016_6148	COG0765	amino acid transport
AA2016_6149	COG1126	abc transporter atp-binding protein
AA2016_6154	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA2016_6156	COG0028	Belongs to the TPP enzyme family
AA2016_6158	COG3842	ATPase activity
AA2016_6159	COG1177	transmembrane transport
AA2016_6160	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_6166	COG3474	cytochrome
AA2016_6169	COG5598	trimethylamine methyltransferase
AA2016_6170	COG0747	negative chemotaxis
AA2016_6171	COG5012	cobalamin binding
AA2016_6172	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_6173	COG1902	pentaerythritol trinitrate reductase activity
AA2016_6173	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_6174	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA2016_6177	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_6182	COG1063	alcohol dehydrogenase
AA2016_6183	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA2016_6184	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA2016_6185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_6186	COG0601	transmembrane transport
AA2016_6189	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_6191	COG1522	sequence-specific DNA binding
AA2016_6198	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA2016_6201	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_6202	COG0473	3-isopropylmalate dehydrogenase activity
AA2016_6204	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_6205	COG1120	ATPase activity
AA2016_6215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AA2016_6216	COG0459	protein refolding
AA2016_6221	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA2016_6229	COG1063	alcohol dehydrogenase
AA2016_6230	COG3284	Transcriptional regulator
AA2016_6232	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2016_6234	COG1116	anion transmembrane transporter activity
AA2016_6235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA2016_6235	COG1648	precorrin-2 dehydrogenase activity
AA2016_6240	COG3685	Protein conserved in bacteria
AA2016_6245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA2016_6271	COG2271	Major facilitator Superfamily
AA2016_6272	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA2016_6275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2016_6276	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_6278	COG1024	Enoyl-CoA hydratase
AA2016_6279	COG0683	leucine binding
AA2016_6280	COG0410	ABC transporter
AA2016_6283	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_6284	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_6286	COG1473	amidohydrolase
AA2016_6287	COG1126	abc transporter atp-binding protein
AA2016_6295	COG1959	2 iron, 2 sulfur cluster binding
AA2016_6296	COG4974	Belongs to the 'phage' integrase family
AA2016_6298	COG0517	IMP dehydrogenase activity
AA2016_6300	COG3409	Peptidoglycan-binding domain 1 protein
AA2016_6300	COG3429	Glucose-6-phosphate dehydrogenase subunit
AA2016_6302	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA2016_6308	COG0745	RESPONSE REGULATOR receiver
AA2016_6308	COG3706	GGDEF domain
AA2016_6309	COG4957	zinc ion binding
AA2016_6312	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_6313	COG0765	amino acid transport
AA2016_6314	COG0765	amino acid transport
AA2016_6315	COG1126	abc transporter atp-binding protein
AA2016_6316	COG3608	succinylglutamate desuccinylase aspartoacylase
AA2016_6326	COG0561	phosphatase activity
AA2016_6327	COG0438	transferase activity, transferring glycosyl groups
AA2016_6329	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AA2016_6335	COG0753	catalase activity
AA2016_6338	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AA2016_6340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AA2016_6348	COG4957	zinc ion binding
AA2016_6353	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA2016_6355	COG3038	cytochrome b561
AA2016_6360	COG3916	Acyl-homoserine-lactone synthase
AA2016_6363	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA2016_6368	COG0189	ligase activity
AA2016_6371	COG1295	ribonuclease BN
AA2016_6378	COG0154	amidase activity
AA2016_6380	COG0583	DNA-binding transcription factor activity
AA2016_6382	COG3290	protein histidine kinase activity
AA2016_6382	COG3829	transcription factor binding
AA2016_6383	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA2016_6384	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AA2016_6385	COG1021	2,3-dihydroxybenzoate-AMP ligase
AA2016_6386	COG1024	Enoyl-CoA hydratase
AA2016_6387	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_6388	COG1960	acyl-CoA dehydrogenase activity
AA2016_6389	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_6393	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_6394	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_6395	COG0183	Belongs to the thiolase family
AA2016_6396	COG1335	isochorismatase
AA2016_6398	COG4608	Belongs to the ABC transporter superfamily
AA2016_6399	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_6402	COG2084	Dehydrogenase
AA2016_6407	COG3701	Conjugal transfer protein
AA2016_6408	COG3846	protein secretion by the type IV secretion system
AA2016_6409	COG5314	conjugation
AA2016_6410	COG3451	type IV secretory pathway VirB4
AA2016_6411	COG5268	conjugation
AA2016_6412	COG3838	Conjugal transfer protein Trbc
AA2016_6413	COG4962	Type ii secretion system protein e
AA2016_6415	COG1192	Involved in chromosome partitioning
AA2016_6416	COG1475	DNA binding
AA2016_6417	COG1414	Transcriptional regulator
AA2016_6418	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AA2016_6432	COG0174	glutamine synthetase
AA2016_6441	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_6443	COG3842	ATPase activity
AA2016_6444	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_6448	COG1959	2 iron, 2 sulfur cluster binding
AA2016_6449	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_6451	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2016_6454	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA2016_6457	COG1942	4-Oxalocrotonate Tautomerase
AA2016_6459	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_6462	COG0523	cobalamin synthesis protein
AA2016_6464	COG1959	2 iron, 2 sulfur cluster binding
AA2016_6470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA2016_6473	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA2016_6475	COG1401	restriction endodeoxyribonuclease activity
AA2016_6475	COG1401	restriction endodeoxyribonuclease activity
AA2016_6479	COG0420	3'-5' exonuclease activity
AA2016_6480	COG4717	serine-type aminopeptidase activity
AA2016_6483	COG1431	PFAM Stem cell self-renewal protein Piwi
AA2016_6491	COG1475	DNA binding
AA2016_6499	COG4227	nucleotidyltransferase activity
AA2016_6501	COG5489	Protein of unknown function (DUF736)
AA2016_6518	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2016_6519	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AA2016_6520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA2016_6521	COG3958	Transketolase
AA2016_6522	COG3959	Transketolase, thiamine diphosphate binding domain
AA2016_6523	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_6524	COG3618	amidohydrolase
AA2016_6525	COG1879	ABC-type sugar transport system periplasmic component
AA2016_6526	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_6527	COG1129	ABC transporter
AA2016_6528	COG0583	DNA-binding transcription factor activity
AA2016_6532	COG3701	Conjugal transfer protein
AA2016_6533	COG3846	protein secretion by the type IV secretion system
AA2016_6535	COG5314	conjugation
AA2016_6536	COG3451	type IV secretory pathway VirB4
AA2016_6538	COG3838	Conjugal transfer protein Trbc
AA2016_6539	COG4962	Type ii secretion system protein e
AA2016_6542	COG4962	Type ii secretion system protein e
AA2016_6543	COG3838	Conjugal transfer protein Trbc
AA2016_6545	COG3451	type IV secretory pathway VirB4
AA2016_6546	COG5314	conjugation
AA2016_6548	COG3846	protein secretion by the type IV secretion system
AA2016_6549	COG3701	Conjugal transfer protein
AA2016_6555	COG2963	transposase activity
AA2016_6556	COG2801	Transposase and inactivated derivatives
AA2016_6561	COG4608	Belongs to the ABC transporter superfamily
AA2016_6562	COG0444	Belongs to the ABC transporter superfamily
AA2016_6564	COG0601	transmembrane transport
AA2016_6565	COG0747	negative chemotaxis
AA2016_6570	COG0411	ABC transporter
AA2016_6574	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA2016_6578	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_6581	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_6582	COG3473	Maleate cis-trans isomerase
AA2016_6583	COG0596	Alpha beta hydrolase
AA2016_6584	COG2309	aminopeptidase activity
AA2016_6585	COG1335	isochorismatase
AA2016_6590	COG1309	transcriptional regulator
AA2016_6592	COG0270	DNA (cytosine-5-)-methyltransferase activity
AA2016_6594	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_6596	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_6599	COG0410	ABC transporter
AA2016_6600	COG0411	ABC transporter
AA2016_6603	COG0183	Belongs to the thiolase family
AA2016_6611	COG1053	succinate dehydrogenase
AA2016_6612	COG0625	glutathione transferase activity
AA2016_6618	COG0411	ABC transporter
AA2016_6620	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_6623	COG1053	succinate dehydrogenase
AA2016_6625	COG0667	Aldo Keto reductase
AA2016_6633	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA2016_6636	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_6636	COG0596	Alpha beta hydrolase
AA2016_6637	COG1053	succinate dehydrogenase
AA2016_6647	COG0776	regulation of translation
AA2016_6648	COG5489	Protein of unknown function (DUF736)
AA2016_6656	COG1431	PFAM Stem cell self-renewal protein Piwi
AA2016_6658	COG3177	Filamentation induced by cAMP protein fic
AA2016_6664	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AA2016_6665	COG0640	Transcriptional regulator
AA2016_6666	COG1475	DNA binding