locus-tag	class	description
CO731_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO731_00002	COG0592	DNA-directed DNA polymerase activity
CO731_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO731_00008	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO731_00010	COG0735	belongs to the Fur family
CO731_00011	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO731_00013	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO731_00014	COG5001	Diguanylate cyclase
CO731_00014	COG3300	MHYT domain
CO731_00015	COG2813	Specifically methylates the guanine in position
CO731_00016	COG1185	polyribonucleotide nucleotidyltransferase activity
CO731_00017	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO731_00018	COG0598	Magnesium transport protein CorA
CO731_00019	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO731_00020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO731_00021	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO731_00024	COG0779	Required for maturation of 30S ribosomal subunits
CO731_00030	COG0745	RESPONSE REGULATOR receiver
CO731_00031	COG0642	Histidine kinase
CO731_00032	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO731_00033	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO731_00034	COG1396	sequence-specific DNA binding
CO731_00035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CO731_00037	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO731_00038	COG1702	phosphate starvation-inducible protein PhoH
CO731_00039	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO731_00040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_00045	COG1214	PFAM Peptidase M22, glycoprotease
CO731_00046	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CO731_00053	COG2827	Endonuclease containing a URI domain
CO731_00054	COG0481	GTPase activity
CO731_00063	COG2827	Endonuclease containing a URI domain
CO731_00067	COG0671	phosphoesterase, PA-phosphatase related
CO731_00069	COG0659	secondary active sulfate transmembrane transporter activity
CO731_00070	COG0443	Heat shock 70 kDa protein
CO731_00074	COG3795	YCII-related domain
CO731_00081	COG0640	Transcriptional regulator
CO731_00083	COG0625	glutathione transferase activity
CO731_00087	COG0842	Transport permease protein
CO731_00088	COG1131	(ABC) transporter
CO731_00096	COG1420	regulation of RNA biosynthetic process
CO731_00097	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CO731_00099	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CO731_00100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO731_00103	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CO731_00104	COG0792	nuclease activity
CO731_00106	COG1254	Belongs to the acylphosphatase family
CO731_00107	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CO731_00108	COG2124	cytochrome p450
CO731_00111	COG3920	Histidine kinase
CO731_00112	COG0187	DNA topoisomerase II activity
CO731_00114	COG0024	Methionine aminopeptidase
CO731_00117	COG2205	protein histidine kinase activity
CO731_00118	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CO731_00119	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CO731_00120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CO731_00123	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO731_00126	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CO731_00127	COG2226	methyltransferase
CO731_00128	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CO731_00129	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO731_00133	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CO731_00139	COG2900	Belongs to the SlyX family
CO731_00142	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_00147	COG0583	DNA-binding transcription factor activity
CO731_00148	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CO731_00150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CO731_00151	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_00153	COG4172	Belongs to the ABC transporter superfamily
CO731_00154	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_00155	COG0601	transmembrane transport
CO731_00156	COG4166	transmembrane transport
CO731_00158	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_00159	COG1473	amidohydrolase
CO731_00160	COG4166	transmembrane transport
CO731_00165	COG2801	Transposase and inactivated derivatives
CO731_00165	COG3415	Transposase
CO731_00171	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO731_00175	COG0395	ABC-type sugar transport system, permease component
CO731_00176	COG1175	transmembrane transport
CO731_00179	COG1765	OsmC-like protein
CO731_00180	COG2766	serine protein kinase
CO731_00181	COG2718	Belongs to the UPF0229 family
CO731_00182	COG2719	SpoVR family
CO731_00183	COG3142	Participates in the control of copper homeostasis
CO731_00184	COG1940	carbohydrate kinase activity
CO731_00186	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_00187	COG1446	asparaginase
CO731_00189	COG0765	amino acid transport
CO731_00190	COG0765	amino acid transport
CO731_00204	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO731_00205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_00206	COG1280	lysine exporter protein (LysE YggA)
CO731_00207	COG1957	nucleoside hydrolase
CO731_00210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_00211	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CO731_00212	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CO731_00213	COG1137	ATPase activity
CO731_00214	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CO731_00216	COG0616	signal peptide processing
CO731_00217	COG0776	regulation of translation
CO731_00219	COG2423	ornithine cyclodeaminase activity
CO731_00220	COG0116	Belongs to the methyltransferase superfamily
CO731_00220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO731_00222	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO731_00228	COG1252	NADH dehydrogenase
CO731_00230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO731_00233	COG0175	sulfate reduction
CO731_00234	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CO731_00236	COG1648	precorrin-2 dehydrogenase activity
CO731_00236	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CO731_00238	COG4651	solute:proton antiporter activity
CO731_00238	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CO731_00240	COG1846	Transcriptional regulator
CO731_00242	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CO731_00249	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO731_00251	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO731_00251	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO731_00252	COG1280	lysine exporter protein (LysE YggA)
CO731_00254	COG0667	Aldo Keto reductase
CO731_00255	COG0673	inositol 2-dehydrogenase activity
CO731_00258	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CO731_00260	COG1609	Transcriptional regulator
CO731_00261	COG1653	transport
CO731_00262	COG1175	transmembrane transport
CO731_00263	COG0395	ABC-type sugar transport system, permease component
CO731_00264	COG0366	Alpha amylase catalytic
CO731_00265	COG3842	ATPase activity
CO731_00266	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO731_00267	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO731_00268	COG1121	(ABC) transporter
CO731_00269	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO731_00272	COG1404	Belongs to the peptidase S8 family
CO731_00274	COG1595	DNA-templated transcription, initiation
CO731_00276	COG0444	Belongs to the ABC transporter superfamily
CO731_00279	COG0747	negative chemotaxis
CO731_00280	COG2936	dipeptidyl-peptidase activity
CO731_00281	COG1309	transcriptional regulator
CO731_00298	COG4974	Belongs to the 'phage' integrase family
CO731_00300	COG0444	Belongs to the ABC transporter superfamily
CO731_00301	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_00305	COG2814	Major facilitator Superfamily
CO731_00311	COG2814	Major facilitator Superfamily
CO731_00319	COG0583	DNA-binding transcription factor activity
CO731_00321	COG0251	oxidation-reduction process
CO731_00326	COG0583	DNA-binding transcription factor activity
CO731_00327	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_00331	COG3415	Transposase
CO731_00331	COG2801	Transposase and inactivated derivatives
CO731_00341	COG0765	amino acid transport
CO731_00342	COG0765	amino acid transport
CO731_00343	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_00344	COG1126	abc transporter atp-binding protein
CO731_00347	COG2072	flavoprotein involved in K transport
CO731_00348	COG0583	DNA-binding transcription factor activity
CO731_00354	COG1136	(ABC) transporter
CO731_00354	COG0577	efflux transmembrane transporter activity
CO731_00364	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_00365	COG0601	transmembrane transport
CO731_00371	COG0583	DNA-binding transcription factor activity
CO731_00379	COG3451	type IV secretory pathway VirB4
CO731_00381	COG3838	Conjugal transfer protein Trbc
CO731_00382	COG4962	Type ii secretion system protein e
CO731_00399	COG5489	Protein of unknown function (DUF736)
CO731_00413	COG1072	(Pantothenic acid kinase))
CO731_00415	COG0625	glutathione transferase activity
CO731_00418	COG0829	nickel cation binding
CO731_00419	COG0831	urea catabolic process
CO731_00420	COG3813	Protein conserved in bacteria
CO731_00421	COG0832	Belongs to the urease beta subunit family
CO731_00425	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CO731_00426	COG0830	nickel cation binding
CO731_00428	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CO731_00430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_00432	COG0583	DNA-binding transcription factor activity
CO731_00433	COG0534	Mate efflux family protein
CO731_00435	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_00436	COG3842	ATPase activity
CO731_00438	COG0765	amino acid transport
CO731_00439	COG0765	amino acid transport
CO731_00442	COG0583	DNA-binding transcription factor activity
CO731_00443	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO731_00446	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO731_00448	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO731_00451	COG1335	isochorismatase
CO731_00453	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CO731_00457	COG1846	Transcriptional regulator
CO731_00458	COG1012	belongs to the aldehyde dehydrogenase family
CO731_00459	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CO731_00464	COG0673	inositol 2-dehydrogenase activity
CO731_00465	COG0395	ABC-type sugar transport system, permease component
CO731_00468	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CO731_00469	COG2971	BadF BadG BcrA BcrD
CO731_00470	COG2188	Transcriptional regulator
CO731_00472	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CO731_00476	COG1879	ABC-type sugar transport system periplasmic component
CO731_00477	COG1129	ABC transporter
CO731_00478	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_00479	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_00480	COG1609	Transcriptional regulator
CO731_00482	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_00484	COG4941	Belongs to the sigma-70 factor family
CO731_00485	COG3795	YCII-related domain
CO731_00486	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CO731_00494	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CO731_00495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO731_00496	COG4335	DNA alkylation repair
CO731_00502	COG0121	glutamine amidotransferase
CO731_00503	COG0756	dUTP diphosphatase activity
CO731_00504	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_00505	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CO731_00507	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_00510	COG0280	phosphate acetyltransferase
CO731_00510	COG0281	malic enzyme
CO731_00511	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO731_00521	COG0596	Alpha beta hydrolase
CO731_00522	COG0662	Cupin 2, conserved barrel domain protein
CO731_00522	COG2207	Transcriptional regulator
CO731_00524	COG1309	transcriptional regulator
CO731_00528	COG5001	Diguanylate cyclase
CO731_00528	COG5002	protein histidine kinase activity
CO731_00530	COG0656	L-ascorbic acid biosynthetic process
CO731_00533	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CO731_00534	COG0728	peptidoglycan biosynthetic process
CO731_00535	COG0180	Tryptophanyl-tRNA synthetase
CO731_00537	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CO731_00538	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_00540	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CO731_00542	COG1643	Atp-dependent helicase
CO731_00547	COG0673	inositol 2-dehydrogenase activity
CO731_00548	COG1737	Transcriptional regulator
CO731_00549	COG0129	dihydroxy-acid dehydratase activity
CO731_00551	COG0626	cystathionine gamma-synthase activity
CO731_00552	COG1846	Transcriptional regulator
CO731_00553	COG0697	spore germination
CO731_00554	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_00555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CO731_00556	COG4521	taurine ABC transporter
CO731_00558	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_00559	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_00561	COG1137	ATPase activity
CO731_00563	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO731_00565	COG0683	leucine binding
CO731_00568	COG3485	protocatechuate 3,4-dioxygenase
CO731_00569	COG3485	protocatechuate 3,4-dioxygenase
CO731_00570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CO731_00571	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_00572	COG0583	DNA-binding transcription factor activity
CO731_00573	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_00574	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CO731_00575	COG1802	Transcriptional regulator
CO731_00576	COG0579	oxidoreductase
CO731_00578	COG1522	sequence-specific DNA binding
CO731_00579	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO731_00580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_00582	COG0739	heme binding
CO731_00582	COG0741	lytic transglycosylase activity
CO731_00582	COG1196	nuclear chromosome segregation
CO731_00587	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_00589	COG3395	kinase activity
CO731_00590	COG4608	Belongs to the ABC transporter superfamily
CO731_00591	COG0444	Belongs to the ABC transporter superfamily
CO731_00594	COG0747	negative chemotaxis
CO731_00595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CO731_00596	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_00598	COG1454	alcohol dehydrogenase
CO731_00603	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO731_00605	COG1022	Amp-dependent synthetase and ligase
CO731_00607	COG0861	Integral membrane protein TerC family
CO731_00619	COG0156	8-amino-7-oxononanoate synthase activity
CO731_00620	COG1063	alcohol dehydrogenase
CO731_00622	COG4608	Belongs to the ABC transporter superfamily
CO731_00624	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_00625	COG0601	transmembrane transport
CO731_00628	COG2186	Transcriptional regulator
CO731_00631	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CO731_00632	COG0400	carboxylic ester hydrolase activity
CO731_00634	COG2124	cytochrome p450
CO731_00637	COG4206	TonB-dependent receptor
CO731_00640	COG1120	ATPase activity
CO731_00643	COG0848	biopolymer transport protein
CO731_00650	COG4264	IucA IucC family
CO731_00651	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_00653	COG1082	Xylose isomerase domain protein TIM barrel
CO731_00654	COG4607	ABC-type enterochelin transport system periplasmic component
CO731_00655	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_00656	COG4605	iron ion homeostasis
CO731_00657	COG4604	ABC transporter, ATP-binding protein
CO731_00659	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_00661	COG0411	ABC transporter
CO731_00665	COG2271	Major facilitator Superfamily
CO731_00666	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_00669	COG4638	Rieske (2fe-2S)
CO731_00674	COG0640	Transcriptional regulator
CO731_00675	COG0798	PFAM Bile acid sodium symporter
CO731_00677	COG0431	NADPH-dependent FMN reductase
CO731_00679	COG4974	Belongs to the 'phage' integrase family
CO731_00680	COG0517	IMP dehydrogenase activity
CO731_00695	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CO731_00699	COG1953	Uracil, thiamine, allantoin
CO731_00701	COG0583	DNA-binding transcription factor activity
CO731_00704	COG0582	viral genome integration into host DNA
CO731_00705	COG4974	Belongs to the 'phage' integrase family
CO731_00707	COG4372	Transposase
CO731_00708	COG2801	Transposase and inactivated derivatives
CO731_00711	COG3436	PFAM IS66 Orf2 family protein
CO731_00714	COG0006	proline dipeptidase activity
CO731_00716	COG1129	ABC transporter
CO731_00717	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_00722	COG4372	Transposase
CO731_00724	COG2801	Transposase and inactivated derivatives
CO731_00726	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_00726	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_00729	COG4977	sequence-specific DNA binding
CO731_00733	COG3547	Transposase (IS116 IS110 IS902 family)
CO731_00735	COG3547	Transposase (IS116 IS110 IS902 family)
CO731_00738	COG3842	ATPase activity
CO731_00740	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_00742	COG0583	DNA-binding transcription factor activity
CO731_00748	COG0010	Belongs to the arginase family
CO731_00752	COG0583	DNA-binding transcription factor activity
CO731_00758	COG0402	S-adenosylhomocysteine deaminase activity
CO731_00759	COG3842	ATPase activity
CO731_00761	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_00769	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO731_00770	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_00771	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO731_00772	COG0539	negative regulation of cytoplasmic translation
CO731_00776	COG1309	transcriptional regulator
CO731_00779	COG4215	(ABC) transporter
CO731_00781	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CO731_00783	COG3237	CsbD-like
CO731_00785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO731_00786	COG1968	undecaprenyl-diphosphatase activity
CO731_00788	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CO731_00790	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CO731_00791	COG1803	Methylglyoxal synthase
CO731_00792	COG0837	glucose binding
CO731_00793	COG1132	(ABC) transporter
CO731_00794	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO731_00795	COG0588	phosphoglycerate mutase activity
CO731_00797	COG0463	Glycosyl transferase, family 2
CO731_00798	COG1295	ribonuclease BN
CO731_00803	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO731_00805	COG3386	PFAM SMP-30 Gluconolaconase
CO731_00806	COG0800	Aldolase
CO731_00807	COG3734	2-keto-3-deoxy-galactonokinase
CO731_00808	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_00809	COG5001	Diguanylate cyclase
CO731_00810	COG0189	ligase activity
CO731_00812	COG5001	Diguanylate cyclase
CO731_00813	COG0606	chelatase, subunit chli
CO731_00851	COG0305	Participates in initiation and elongation during chromosome replication
CO731_00858	COG4974	Belongs to the 'phage' integrase family
CO731_00864	COG0284	orotidine-5'-phosphate decarboxylase activity
CO731_00866	COG3963	phosphatidate phosphatase activity
CO731_00867	COG0484	heat shock protein binding
CO731_00868	COG0443	Heat shock 70 kDa protein
CO731_00874	COG0072	phenylalanine-tRNA ligase activity
CO731_00874	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO731_00876	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO731_00877	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO731_00878	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO731_00880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO731_00882	COG3135	benzoate transporter
CO731_00885	COG0135	phosphoribosylanthranilate isomerase activity
CO731_00886	COG0133	tryptophan synthase activity
CO731_00887	COG0159	tryptophan synthase activity
CO731_00888	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CO731_00891	COG1074	ATP-dependent DNA helicase activity
CO731_00892	COG2887	Belongs to the helicase family. UvrD subfamily
CO731_00893	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CO731_00894	COG3178	'Phosphotransferase
CO731_00895	COG2205	protein histidine kinase activity
CO731_00896	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CO731_00897	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_00898	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO731_00898	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_00900	COG2205	protein histidine kinase activity
CO731_00901	COG0745	RESPONSE REGULATOR receiver
CO731_00902	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CO731_00904	COG1652	LysM domain
CO731_00905	COG3145	DNA-N1-methyladenine dioxygenase activity
CO731_00906	COG1072	(Pantothenic acid kinase))
CO731_00907	COG0140	phosphoribosyl-ATP diphosphatase activity
CO731_00908	COG0107	imidazoleglycerol-phosphate synthase activity
CO731_00909	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CO731_00910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CO731_00912	COG0131	Imidazoleglycerol-phosphate dehydratase
CO731_00913	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CO731_00917	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CO731_00919	COG3800	Transcriptional regulator
CO731_00919	COG1396	sequence-specific DNA binding
CO731_00924	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CO731_00925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO731_00926	COG0237	dephospho-CoA kinase activity
CO731_00927	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO731_00928	COG0424	maF-like protein
CO731_00929	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO731_00930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CO731_00932	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CO731_00933	COG1331	Highly conserved protein containing a thioredoxin domain
CO731_00934	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO731_00935	COG0445	tRNA wobble uridine modification
CO731_00936	COG0357	Ribosomal RNA small subunit methyltransferase G
CO731_00937	COG1192	Involved in chromosome partitioning
CO731_00938	COG1475	DNA binding
CO731_00950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO731_00955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CO731_00956	COG1268	BioY protein
CO731_00957	COG1396	sequence-specific DNA binding
CO731_00957	COG3800	Transcriptional regulator
CO731_00959	COG2183	response to ionizing radiation
CO731_00960	COG0137	argininosuccinate synthase activity
CO731_00967	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO731_00968	COG0287	Prephenate dehydrogenase
CO731_00968	COG1605	Chorismate mutase
CO731_00969	COG0228	four-way junction DNA binding
CO731_00971	COG3781	membrane
CO731_00973	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO731_00977	COG4178	(ABC) transporter
CO731_00978	COG3152	Membrane
CO731_00979	COG0473	3-isopropylmalate dehydrogenase activity
CO731_00982	COG0251	oxidation-reduction process
CO731_00984	COG0066	3-isopropylmalate dehydratase activity
CO731_00985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CO731_00986	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_00987	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_00991	COG2814	Major facilitator Superfamily
CO731_01003	COG1278	Cold shock
CO731_01007	COG2301	Belongs to the HpcH HpaI aldolase family
CO731_01011	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO731_01012	COG0587	DNA-directed DNA polymerase activity
CO731_01013	COG2835	tetraacyldisaccharide 4'-kinase activity
CO731_01014	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CO731_01015	COG3118	belongs to the thioredoxin family
CO731_01018	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01019	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_01020	COG0179	Fumarylacetoacetate (FAA) hydrolase
CO731_01022	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_01023	COG1129	ABC transporter
CO731_01025	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01027	COG4154	Belongs to the RbsD FucU family
CO731_01028	COG4608	Belongs to the ABC transporter superfamily
CO731_01029	COG0444	Belongs to the ABC transporter superfamily
CO731_01030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_01031	COG0601	transmembrane transport
CO731_01032	COG0747	negative chemotaxis
CO731_01034	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO731_01037	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CO731_01039	COG0456	acetyltransferase
CO731_01041	COG3339	Conserved Protein
CO731_01042	COG2154	pterin-4-alpha-carbinolamine dehydratase
CO731_01043	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO731_01044	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CO731_01046	COG1136	(ABC) transporter
CO731_01048	COG0670	Belongs to the BI1 family
CO731_01050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CO731_01051	COG1012	belongs to the aldehyde dehydrogenase family
CO731_01056	COG5001	Diguanylate cyclase
CO731_01056	COG3300	MHYT domain
CO731_01063	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CO731_01065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CO731_01066	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO731_01067	COG0552	protein localization to endoplasmic reticulum
CO731_01068	COG2917	probably involved in intracellular septation
CO731_01071	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO731_01073	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CO731_01074	COG4133	protoheme IX ABC transporter activity
CO731_01075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO731_01076	COG0039	L-malate dehydrogenase activity
CO731_01077	COG0045	succinate-CoA ligase (ADP-forming) activity
CO731_01078	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO731_01079	COG0567	Dehydrogenase, E1 component
CO731_01080	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_01083	COG1280	lysine exporter protein (LysE YggA)
CO731_01085	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01089	COG4974	Belongs to the 'phage' integrase family
CO731_01090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO731_01093	COG0336	Belongs to the RNA methyltransferase TrmD family
CO731_01097	COG0335	large ribosomal subunit rRNA binding
CO731_01099	COG0765	amino acid transport
CO731_01100	COG2226	methyltransferase
CO731_01103	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CO731_01104	COG3706	GGDEF domain
CO731_01106	COG2009	succinate dehydrogenase
CO731_01112	COG3132	Protein of unknown function, DUF480
CO731_01115	COG1764	response to oxidative stress
CO731_01116	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CO731_01117	COG1946	Acyl-CoA thioesterase
CO731_01118	COG0347	Belongs to the P(II) protein family
CO731_01119	COG0004	ammonium transporteR
CO731_01124	COG1674	ftsk spoiiie
CO731_01124	COG2261	transglycosylase associated protein
CO731_01125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CO731_01128	COG0745	RESPONSE REGULATOR receiver
CO731_01131	COG0583	DNA-binding transcription factor activity
CO731_01135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO731_01136	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO731_01137	COG0181	hydroxymethylbilane synthase activity
CO731_01145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO731_01145	COG2755	lipolytic protein G-D-S-L family
CO731_01147	COG3239	Fatty acid desaturase
CO731_01149	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_01150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_01152	COG4176	ABC-type proline glycine betaine transport system permease component
CO731_01153	COG3448	diguanylate cyclase activity
CO731_01153	COG4175	Glycine betaine
CO731_01155	COG0745	RESPONSE REGULATOR receiver
CO731_01158	COG1879	ABC-type sugar transport system periplasmic component
CO731_01159	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_01160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO731_01161	COG1012	belongs to the aldehyde dehydrogenase family
CO731_01165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_01169	COG1872	DUF167
CO731_01171	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CO731_01175	COG1704	LemA family
CO731_01180	COG2814	Major facilitator Superfamily
CO731_01188	COG2270	Major facilitator Superfamily
CO731_01189	COG0138	bifunctional purine biosynthesis protein purh
CO731_01192	COG0501	Belongs to the peptidase M48B family
CO731_01196	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_01197	COG5425	PFAM Usg family protein
CO731_01202	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CO731_01203	COG0495	leucyl-tRNA aminoacylation
CO731_01207	COG1522	sequence-specific DNA binding
CO731_01208	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CO731_01214	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO731_01216	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO731_01217	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO731_01218	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO731_01220	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CO731_01221	COG1088	dTDP-glucose 4,6-dehydratase activity
CO731_01222	COG1091	dTDP-4-dehydrorhamnose reductase activity
CO731_01224	COG3754	Rhamnan synthesis protein F
CO731_01226	COG3754	Rhamnan synthesis protein F
CO731_01227	COG3842	ATPase activity
CO731_01228	COG0402	S-adenosylhomocysteine deaminase activity
CO731_01229	COG1082	Xylose isomerase domain protein TIM barrel
CO731_01231	COG0395	ABC-type sugar transport system, permease component
CO731_01234	COG4608	Belongs to the ABC transporter superfamily
CO731_01235	COG0402	S-adenosylhomocysteine deaminase activity
CO731_01236	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_01238	COG4533	DNA binding
CO731_01239	COG0444	Belongs to the ABC transporter superfamily
CO731_01244	COG0459	protein refolding
CO731_01245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO731_01249	COG0514	ATP-dependent DNA helicase (RecQ)
CO731_01250	COG0582	viral genome integration into host DNA
CO731_01267	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO731_01268	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO731_01271	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO731_01272	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CO731_01273	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CO731_01274	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO731_01278	COG0799	negative regulation of ribosome biogenesis
CO731_01279	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO731_01281	COG0793	Belongs to the peptidase S41A family
CO731_01283	COG0494	nUDIX hydrolase
CO731_01284	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_01286	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_01293	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_01294	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_01299	COG0410	ABC transporter
CO731_01302	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CO731_01304	COG2223	nitrite transmembrane transporter activity
CO731_01306	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_01309	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01312	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CO731_01313	COG0741	lytic transglycosylase activity
CO731_01314	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_01318	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO731_01319	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO731_01322	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CO731_01323	COG0183	Belongs to the thiolase family
CO731_01324	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO731_01329	COG1329	Transcriptional regulator
CO731_01330	COG1126	abc transporter atp-binding protein
CO731_01332	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_01333	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO731_01335	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CO731_01337	COG4143	(ABC) transporter
CO731_01343	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CO731_01345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_01346	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CO731_01349	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO731_01353	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO731_01354	COG0037	tRNA processing
CO731_01356	COG2885	chlorophyll binding
CO731_01359	COG0848	biopolymer transport protein
CO731_01362	COG0824	Thioesterase
CO731_01364	COG0456	acetyltransferase
CO731_01364	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO731_01365	COG2255	four-way junction helicase activity
CO731_01368	COG0632	four-way junction helicase activity
CO731_01372	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CO731_01376	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_01380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO731_01381	COG0483	inositol monophosphate 1-phosphatase activity
CO731_01382	COG1272	protein, Hemolysin III
CO731_01390	COG1132	(ABC) transporter
CO731_01391	COG0254	rRNA binding
CO731_01393	COG0702	epimerase
CO731_01395	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO731_01397	COG0217	transcriptional regulatory protein
CO731_01399	COG3706	GGDEF domain
CO731_01401	COG1733	regulation of RNA biosynthetic process
CO731_01405	COG0305	Participates in initiation and elongation during chromosome replication
CO731_01406	COG0861	Integral membrane protein TerC family
CO731_01407	COG1692	metallophosphoesterase
CO731_01414	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_01416	COG3750	Belongs to the UPF0335 family
CO731_01420	COG0469	pyruvate kinase activity
CO731_01421	COG2267	carboxylic ester hydrolase activity
CO731_01422	COG0457	Tetratricopeptide repeat
CO731_01425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CO731_01429	COG0640	Transcriptional regulator
CO731_01432	COG3321	synthase
CO731_01432	COG0604	alcohol dehydrogenase
CO731_01432	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01439	COG4191	Histidine kinase
CO731_01448	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01471	COG3588	fructose-bisphosphate aldolase
CO731_01472	COG0126	phosphoglycerate kinase activity
CO731_01480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO731_01481	COG0564	pseudouridine synthase activity
CO731_01483	COG0346	lactoylglutathione lyase activity
CO731_01498	COG1525	nuclease
CO731_01504	COG2801	Transposase and inactivated derivatives
CO731_01504	COG3415	Transposase
CO731_01531	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CO731_01542	COG2205	protein histidine kinase activity
CO731_01542	COG5002	protein histidine kinase activity
CO731_01542	COG0784	Response regulator, receiver
CO731_01544	COG0573	inorganic phosphate transmembrane transporter activity
CO731_01546	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO731_01547	COG0704	Plays a role in the regulation of phosphate uptake
CO731_01548	COG0745	RESPONSE REGULATOR receiver
CO731_01549	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_01553	COG4213	ABC transporter substrate-binding protein
CO731_01554	COG4214	carbohydrate transport
CO731_01559	COG3920	Histidine kinase
CO731_01559	COG2202	Pas domain
CO731_01561	COG0784	Response regulator, receiver
CO731_01565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO731_01576	COG0346	lactoylglutathione lyase activity
CO731_01577	COG0400	carboxylic ester hydrolase activity
CO731_01580	COG2200	EAL domain
CO731_01580	COG2199	diguanylate cyclase activity
CO731_01580	COG2203	Gaf domain
CO731_01581	COG0745	RESPONSE REGULATOR receiver
CO731_01582	COG0745	RESPONSE REGULATOR receiver
CO731_01585	COG1178	ABC-type Fe3 transport system permease component
CO731_01586	COG3842	ATPase activity
CO731_01590	COG0483	inositol monophosphate 1-phosphatase activity
CO731_01591	COG0483	inositol monophosphate 1-phosphatase activity
CO731_01596	COG1840	ABC-type Fe3 transport system, periplasmic component
CO731_01598	COG3842	ATPase activity
CO731_01599	COG1238	metal cluster binding
CO731_01601	COG2132	Multicopper oxidase
CO731_01606	COG2217	Heavy metal translocating P-type atpase
CO731_01607	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CO731_01608	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CO731_01610	COG1845	cytochrome c oxidase, subunit III
CO731_01616	COG3842	ATPase activity
CO731_01617	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CO731_01623	COG1129	ABC transporter
CO731_01625	COG2186	Transcriptional regulator
CO731_01629	COG0625	glutathione transferase activity
CO731_01630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CO731_01631	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CO731_01632	COG0351	phosphomethylpyrimidine kinase
CO731_01634	COG2022	thiamine diphosphate biosynthetic process
CO731_01637	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CO731_01639	COG0022	dehydrogenase e1 component
CO731_01642	COG0356	it plays a direct role in the translocation of protons across the membrane
CO731_01647	COG0444	Belongs to the ABC transporter superfamily
CO731_01649	COG0747	negative chemotaxis
CO731_01650	COG0601	transmembrane transport
CO731_01651	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_01653	COG0402	S-adenosylhomocysteine deaminase activity
CO731_01655	COG3048	D-serine ammonia-lyase activity
CO731_01656	COG0583	DNA-binding transcription factor activity
CO731_01659	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_01661	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO731_01662	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_01665	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CO731_01666	COG0582	viral genome integration into host DNA
CO731_01681	COG0616	signal peptide processing
CO731_01682	COG0433	COG0433 Predicted ATPase
CO731_01688	COG1473	amidohydrolase
CO731_01689	COG1686	Belongs to the peptidase S11 family
CO731_01690	COG0523	cobalamin synthesis protein
CO731_01691	COG0425	Belongs to the sulfur carrier protein TusA family
CO731_01693	COG0825	malonyl-CoA metabolic process
CO731_01696	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CO731_01697	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CO731_01698	COG4536	flavin adenine dinucleotide binding
CO731_01708	COG1522	sequence-specific DNA binding
CO731_01709	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CO731_01710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO731_01714	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_01715	COG2226	methyltransferase
CO731_01719	COG0583	DNA-binding transcription factor activity
CO731_01720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CO731_01721	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO731_01722	COG0287	Prephenate dehydrogenase
CO731_01729	COG2884	Cell division ATP-binding protein ftsE
CO731_01732	COG0745	RESPONSE REGULATOR receiver
CO731_01734	COG0583	DNA-binding transcription factor activity
CO731_01737	COG0019	diaminopimelate decarboxylase activity
CO731_01739	COG0165	Argininosuccinate lyase
CO731_01740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO731_01741	COG1653	transport
CO731_01742	COG1175	transmembrane transport
CO731_01743	COG0395	ABC-type sugar transport system, permease component
CO731_01744	COG3842	ATPase activity
CO731_01745	COG3706	GGDEF domain
CO731_01746	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_01747	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CO731_01748	COG2086	electron transfer activity
CO731_01752	COG0300	oxidoreductase activity
CO731_01754	COG0697	spore germination
CO731_01756	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO731_01760	COG1238	metal cluster binding
CO731_01762	COG0583	DNA-binding transcription factor activity
CO731_01763	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01768	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_01772	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO731_01773	COG0183	Belongs to the thiolase family
CO731_01775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CO731_01782	COG1309	transcriptional regulator
CO731_01783	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01793	COG0625	glutathione transferase activity
CO731_01794	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_01796	COG0583	DNA-binding transcription factor activity
CO731_01798	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_01805	COG0583	DNA-binding transcription factor activity
CO731_01807	COG2948	multi-organism process
CO731_01810	COG3846	protein secretion by the type IV secretion system
CO731_01813	COG3451	type IV secretory pathway VirB4
CO731_01816	COG4962	Type ii secretion system protein e
CO731_01820	COG0741	lytic transglycosylase activity
CO731_01825	COG1192	Involved in chromosome partitioning
CO731_01831	COG5489	Protein of unknown function (DUF736)
CO731_01854	COG1396	sequence-specific DNA binding
CO731_01855	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CO731_01861	COG1053	succinate dehydrogenase
CO731_01862	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO731_01866	COG0583	DNA-binding transcription factor activity
CO731_01867	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_01868	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CO731_01869	COG0473	3-isopropylmalate dehydrogenase activity
CO731_01873	COG0583	DNA-binding transcription factor activity
CO731_01877	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_01880	COG0653	protein targeting
CO731_01881	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO731_01883	COG1309	transcriptional regulator
CO731_01885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CO731_01887	COG0494	nUDIX hydrolase
CO731_01891	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO731_01893	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CO731_01897	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CO731_01898	COG0527	aspartate kinase activity
CO731_01900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO731_01901	COG2890	protein-(glutamine-N5) methyltransferase activity
CO731_01903	COG0542	response to heat
CO731_01905	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_01906	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO731_01907	COG3153	acetyltransferase
CO731_01911	COG0477	Major facilitator Superfamily
CO731_01913	COG0739	heme binding
CO731_01913	COG0741	lytic transglycosylase activity
CO731_01913	COG1196	nuclear chromosome segregation
CO731_01929	COG2963	transposase activity
CO731_01931	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_01933	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO731_01934	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO731_01940	COG0831	urea catabolic process
CO731_01940	COG0832	Belongs to the urease beta subunit family
CO731_01941	COG0804	urea catabolic process
CO731_01942	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CO731_01943	COG0829	nickel cation binding
CO731_01945	COG0830	nickel cation binding
CO731_01950	COG1396	sequence-specific DNA binding
CO731_01950	COG3800	Transcriptional regulator
CO731_01952	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CO731_01953	COG3791	Glutathione-dependent formaldehyde-activating
CO731_01956	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01957	COG1960	acyl-CoA dehydrogenase activity
CO731_01959	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_01962	COG1802	Transcriptional regulator
CO731_01963	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_01964	COG3246	L-lysine catabolic process to acetate
CO731_01966	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01967	COG0402	S-adenosylhomocysteine deaminase activity
CO731_01968	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_01970	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_01971	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_01976	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_01983	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_01984	COG0673	inositol 2-dehydrogenase activity
CO731_01986	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CO731_01992	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_01993	COG1129	ABC transporter
CO731_01994	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_01997	COG0463	Glycosyl transferase, family 2
CO731_01998	COG1215	transferase activity, transferring glycosyl groups
CO731_02003	COG0205	6-phosphofructokinase activity
CO731_02004	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_02004	COG1388	LysM domain
CO731_02005	COG1280	lysine exporter protein (LysE YggA)
CO731_02008	COG1070	Carbohydrate kinase
CO731_02010	COG2115	Belongs to the xylose isomerase family
CO731_02013	COG4977	sequence-specific DNA binding
CO731_02014	COG3246	L-lysine catabolic process to acetate
CO731_02015	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_02016	COG1960	acyl-CoA dehydrogenase activity
CO731_02017	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO731_02017	COG0045	succinate-CoA ligase (ADP-forming) activity
CO731_02017	COG1042	CoA-binding domain protein
CO731_02021	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_02028	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CO731_02029	COG3257	ureidoglycine aminohydrolase activity
CO731_02031	COG2351	hydroxyisourate hydrolase activity
CO731_02033	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CO731_02035	COG0783	Belongs to the Dps family
CO731_02036	COG1733	regulation of RNA biosynthetic process
CO731_02039	COG0583	DNA-binding transcription factor activity
CO731_02041	COG0402	S-adenosylhomocysteine deaminase activity
CO731_02042	COG4702	Belongs to the UPF0303 family
CO731_02046	COG0174	glutamine synthetase
CO731_02047	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CO731_02052	COG0523	cobalamin synthesis protein
CO731_02054	COG1846	Transcriptional regulator
CO731_02057	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO731_02058	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CO731_02059	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CO731_02065	COG5001	Diguanylate cyclase
CO731_02069	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CO731_02070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CO731_02071	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CO731_02072	COG1280	lysine exporter protein (LysE YggA)
CO731_02075	COG2249	NAD(P)H dehydrogenase (quinone) activity
CO731_02077	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CO731_02079	COG2223	nitrite transmembrane transporter activity
CO731_02081	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_02085	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_02085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_02094	COG0531	amino acid
CO731_02101	COG3842	ATPase activity
CO731_02102	COG0583	DNA-binding transcription factor activity
CO731_02103	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CO731_02104	COG3842	ATPase activity
CO731_02105	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_02106	COG1177	transmembrane transport
CO731_02107	COG1012	belongs to the aldehyde dehydrogenase family
CO731_02110	COG1609	Transcriptional regulator
CO731_02113	COG1024	Enoyl-CoA hydratase
CO731_02114	COG1012	belongs to the aldehyde dehydrogenase family
CO731_02115	COG1653	transport
CO731_02117	COG0395	ABC-type sugar transport system, permease component
CO731_02118	COG3842	ATPase activity
CO731_02120	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_02126	COG2072	flavoprotein involved in K transport
CO731_02134	COG0071	Belongs to the small heat shock protein (HSP20) family
CO731_02136	COG2267	carboxylic ester hydrolase activity
CO731_02138	COG0067	glutamate synthase
CO731_02138	COG0070	glutamate synthase
CO731_02138	COG0069	glutamate synthase activity
CO731_02141	COG2951	lytic endotransglycosylase activity
CO731_02142	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO731_02143	COG0778	Nitroreductase
CO731_02144	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO731_02148	COG0330	HflC and HflK could
CO731_02150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CO731_02151	COG0737	Belongs to the 5'-nucleotidase family
CO731_02153	COG5310	Homospermidine synthase
CO731_02158	COG2204	response regulator
CO731_02159	COG3108	Peptidase M15
CO731_02160	COG0800	Aldolase
CO731_02161	COG5632	N-Acetylmuramoyl-L-alanine amidase
CO731_02161	COG3409	Peptidoglycan-binding domain 1 protein
CO731_02164	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_02171	COG0583	DNA-binding transcription factor activity
CO731_02173	COG0154	amidase activity
CO731_02182	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CO731_02183	COG2020	methyltransferase activity
CO731_02187	COG2814	Major facilitator Superfamily
CO731_02189	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CO731_02190	COG5443	negative regulation of bacterial-type flagellum assembly
CO731_02191	COG5442	Flagellar protein FlaF
CO731_02202	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_02203	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_02205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_02206	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_02207	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_02208	COG1338	Plays a role in the flagellum-specific transport system
CO731_02210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CO731_02212	COG1706	bacterial-type flagellum-dependent cell motility
CO731_02213	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CO731_02214	COG4786	Flagellar basal body rod
CO731_02215	COG1677	Flagellar hook-basal body complex protein FliE
CO731_02216	COG1558	bacterial-type flagellum-dependent cell motility
CO731_02217	COG1815	bacterial-type flagellum-dependent cell motility
CO731_02219	COG1157	protein secretion by the type III secretion system
CO731_02220	COG4786	Flagellar basal body rod
CO731_02222	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CO731_02223	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CO731_02224	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CO731_02225	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CO731_02226	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CO731_02229	COG2771	luxR family
CO731_02232	COG1309	transcriptional regulator
CO731_02233	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CO731_02234	COG3842	ATPase activity
CO731_02235	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_02236	COG1177	transmembrane transport
CO731_02245	COG1609	Transcriptional regulator
CO731_02246	COG1216	Glycosyl transferase, family 2
CO731_02246	COG0463	Glycosyl transferase, family 2
CO731_02250	COG1129	ABC transporter
CO731_02251	COG4211	Belongs to the binding-protein-dependent transport system permease family
CO731_02252	COG0673	inositol 2-dehydrogenase activity
CO731_02253	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_02254	COG3962	Belongs to the TPP enzyme family
CO731_02255	COG1082	Xylose isomerase domain protein TIM barrel
CO731_02257	COG3718	enzyme involved in inositol metabolism
CO731_02258	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CO731_02261	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CO731_02264	COG2197	response regulator
CO731_02268	COG0747	negative chemotaxis
CO731_02273	COG0747	negative chemotaxis
CO731_02276	COG3454	Phosphonate metabolism
CO731_02277	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CO731_02278	COG3639	organic phosphonate transmembrane transporter activity
CO731_02281	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CO731_02283	COG0786	glutamate:sodium symporter activity
CO731_02285	COG4778	phosphonate C-P lyase system protein PhnL
CO731_02286	COG4107	phosphonate C-P lyase system protein PhnK
CO731_02287	COG3627	carbon phosphorus lyase activity
CO731_02289	COG1598	PFAM Uncharacterised protein family UPF0150
CO731_02290	COG3626	phosphonate metabolism
CO731_02291	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CO731_02292	COG3624	Phosphonate C-P lyase system protein PhnG
CO731_02293	COG2188	Transcriptional regulator
CO731_02294	COG3307	-O-antigen
CO731_02295	COG1596	polysaccharide export
CO731_02298	COG1215	transferase activity, transferring glycosyl groups
CO731_02301	COG2273	Hydrolase Family 16
CO731_02307	COG0438	transferase activity, transferring glycosyl groups
CO731_02308	COG1215	transferase activity, transferring glycosyl groups
CO731_02309	COG1215	transferase activity, transferring glycosyl groups
CO731_02310	COG1215	transferase activity, transferring glycosyl groups
CO731_02311	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO731_02312	COG3206	protein involved in exopolysaccharide biosynthesis
CO731_02312	COG0489	protein tyrosine kinase activity
CO731_02313	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CO731_02317	COG0482	sulfurtransferase activity
CO731_02320	COG1733	regulation of RNA biosynthetic process
CO731_02323	COG2201	protein-glutamate methylesterase activity
CO731_02332	COG0435	Glutathione S-transferase
CO731_02333	COG0494	nUDIX hydrolase
CO731_02338	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CO731_02340	COG3180	Ammonia monooxygenase
CO731_02346	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO731_02346	COG0512	Glutamine amidotransferase of anthranilate synthase
CO731_02347	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_02349	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CO731_02350	COG2814	Major facilitator Superfamily
CO731_02351	COG0583	DNA-binding transcription factor activity
CO731_02352	COG2962	Rard protein
CO731_02353	COG4993	Dehydrogenase
CO731_02359	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CO731_02363	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO731_02369	COG1435	thymidine kinase activity
CO731_02371	COG4176	ABC-type proline glycine betaine transport system permease component
CO731_02372	COG3448	diguanylate cyclase activity
CO731_02372	COG4175	Glycine betaine
CO731_02376	COG5507	3-demethylubiquinone-9 3-methyltransferase
CO731_02377	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CO731_02382	COG1278	Cold shock
CO731_02387	COG0714	Associated with various cellular activities
CO731_02390	COG0617	tRNA 3'-terminal CCA addition
CO731_02393	COG0513	Belongs to the DEAD box helicase family
CO731_02396	COG0408	coproporphyrinogen oxidase activity
CO731_02400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CO731_02402	COG1132	(ABC) transporter
CO731_02403	COG1132	(ABC) transporter
CO731_02404	COG1132	(ABC) transporter
CO731_02408	COG2857	Cytochrome c1
CO731_02408	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CO731_02409	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO731_02414	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_02416	COG0012	GTP binding
CO731_02417	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO731_02419	COG0193	aminoacyl-tRNA hydrolase activity
CO731_02420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CO731_02424	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO731_02429	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO731_02432	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO731_02434	COG1464	Belongs to the NlpA lipoprotein family
CO731_02435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO731_02436	COG2011	ABC-type metal ion transport system permease component
CO731_02437	COG2205	protein histidine kinase activity
CO731_02439	COG0745	RESPONSE REGULATOR receiver
CO731_02440	COG1846	Transcriptional regulator
CO731_02441	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_02443	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_02445	COG1278	Cold shock
CO731_02447	COG1278	Cold shock
CO731_02450	COG3791	Glutathione-dependent formaldehyde-activating
CO731_02452	COG2264	protein methyltransferase activity
CO731_02453	COG1396	sequence-specific DNA binding
CO731_02461	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO731_02463	COG1522	sequence-specific DNA binding
CO731_02467	COG0556	nucleotide-excision repair
CO731_02480	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_02482	COG1607	acyl-coa hydrolase
CO731_02485	COG1253	flavin adenine dinucleotide binding
CO731_02494	COG2133	pyrroloquinoline quinone binding
CO731_02495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_02498	COG1215	transferase activity, transferring glycosyl groups
CO731_02501	COG1522	sequence-specific DNA binding
CO731_02502	COG0492	ferredoxin-NADP+ reductase activity
CO731_02503	COG0583	DNA-binding transcription factor activity
CO731_02506	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CO731_02507	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO731_02512	COG5001	Diguanylate cyclase
CO731_02512	COG3300	MHYT domain
CO731_02514	COG0625	glutathione transferase activity
CO731_02515	COG1278	Cold shock
CO731_02517	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO731_02519	COG0456	acetyltransferase
CO731_02525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO731_02526	COG0640	Transcriptional regulator
CO731_02527	COG2814	Major facilitator Superfamily
CO731_02529	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_02531	COG2311	Membrane
CO731_02533	COG2321	neutral zinc metallopeptidase
CO731_02534	COG4989	oxidoreductase activity
CO731_02537	COG0505	Belongs to the CarA family
CO731_02543	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO731_02546	COG1280	lysine exporter protein (LysE YggA)
CO731_02550	COG1309	transcriptional regulator
CO731_02557	COG3685	Protein conserved in bacteria
CO731_02559	COG2862	Uncharacterized protein family, UPF0114
CO731_02561	COG2983	Belongs to the UPF0260 family
CO731_02567	COG1177	transmembrane transport
CO731_02568	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_02569	COG3842	ATPase activity
CO731_02573	COG2207	Transcriptional regulator
CO731_02575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_02576	COG3474	cytochrome
CO731_02584	COG0651	ATP synthesis coupled electron transport
CO731_02586	COG2111	Na H antiporter
CO731_02586	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO731_02589	COG2212	antiporter activity
CO731_02594	COG2235	arginine
CO731_02603	COG2814	Major facilitator Superfamily
CO731_02605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_02607	COG0583	DNA-binding transcription factor activity
CO731_02609	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_02610	COG1917	Cupin 2, conserved barrel domain protein
CO731_02615	COG0410	ABC transporter
CO731_02616	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CO731_02618	COG2124	cytochrome p450
CO731_02622	COG0179	Fumarylacetoacetate (FAA) hydrolase
CO731_02623	COG1082	Xylose isomerase domain protein TIM barrel
CO731_02624	COG2721	sulfolactate sulfo-lyase activity
CO731_02625	COG2721	sulfolactate sulfo-lyase activity
CO731_02627	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_02628	COG0601	transmembrane transport
CO731_02629	COG0747	negative chemotaxis
CO731_02630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_02632	COG0626	cystathionine gamma-synthase activity
CO731_02633	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_02634	COG4597	amino acid ABC transporter
CO731_02635	COG0765	amino acid transport
CO731_02636	COG1126	abc transporter atp-binding protein
CO731_02639	COG0583	DNA-binding transcription factor activity
CO731_02640	COG2814	Major facilitator Superfamily
CO731_02642	COG0590	tRNA wobble adenosine to inosine editing
CO731_02647	COG0601	transmembrane transport
CO731_02650	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_02653	COG1012	belongs to the aldehyde dehydrogenase family
CO731_02654	COG3284	Transcriptional regulator
CO731_02657	COG3284	Transcriptional regulator
CO731_02659	COG4459	periplasmic nitrate reductase
CO731_02664	COG3005	denitrification pathway
CO731_02666	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO731_02673	COG1845	cytochrome c oxidase, subunit III
CO731_02676	COG3256	nitric oxide reductase
CO731_02677	COG0714	Associated with various cellular activities
CO731_02679	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO731_02683	COG3707	response regulator
CO731_02684	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_02686	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CO731_02688	COG0243	molybdopterin cofactor binding
CO731_02691	COG0463	Glycosyl transferase, family 2
CO731_02699	COG2197	response regulator
CO731_02700	COG1280	lysine exporter protein (LysE YggA)
CO731_02705	COG1902	pentaerythritol trinitrate reductase activity
CO731_02708	COG0673	inositol 2-dehydrogenase activity
CO731_02709	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_02710	COG4597	amino acid ABC transporter
CO731_02711	COG0765	amino acid transport
CO731_02716	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO731_02717	COG4208	sulfate ABC transporter
CO731_02718	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CO731_02719	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CO731_02721	COG4953	penicillin-binding protein 1C
CO731_02723	COG0729	surface antigen
CO731_02725	COG0747	negative chemotaxis
CO731_02726	COG0601	transmembrane transport
CO731_02727	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_02730	COG0493	'glutamate synthase
CO731_02734	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CO731_02736	COG1309	transcriptional regulator
CO731_02741	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_02742	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_02747	COG0028	Belongs to the TPP enzyme family
CO731_02749	COG2267	carboxylic ester hydrolase activity
CO731_02750	COG1131	(ABC) transporter
CO731_02751	COG0842	Transport permease protein
CO731_02762	COG1720	tRNA m6t6A37 methyltransferase activity
CO731_02768	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO731_02775	COG0697	spore germination
CO731_02780	COG0626	cystathionine gamma-synthase activity
CO731_02781	COG2001	Belongs to the MraZ family
CO731_02782	COG0275	rRNA processing
CO731_02785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CO731_02787	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO731_02788	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO731_02790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO731_02791	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO731_02792	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO731_02793	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO731_02794	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CO731_02795	COG0849	cell division
CO731_02796	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CO731_02798	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CO731_02801	COG2176	DNA-directed DNA polymerase activity
CO731_02804	COG0006	proline dipeptidase activity
CO731_02804	COG0006	proline dipeptidase activity
CO731_02805	COG2264	protein methyltransferase activity
CO731_02806	COG1999	signal sequence binding
CO731_02813	COG0210	DNA helicase
CO731_02818	COG0277	FAD linked oxidase domain protein
CO731_02827	COG2814	Major facilitator Superfamily
CO731_02834	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_02840	COG0330	HflC and HflK could
CO731_02841	COG0330	HflC and HflK could
CO731_02843	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO731_02847	COG3830	Belongs to the UPF0237 family
CO731_02847	COG0560	Phosphoserine phosphatase
CO731_02848	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO731_02849	COG3706	GGDEF domain
CO731_02854	COG0028	Belongs to the TPP enzyme family
CO731_02863	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO731_02866	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CO731_02867	COG3158	transport of potassium into the cell
CO731_02870	COG1309	transcriptional regulator
CO731_02871	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CO731_02877	COG0577	efflux transmembrane transporter activity
CO731_02877	COG1136	(ABC) transporter
CO731_02878	COG1136	(ABC) transporter
CO731_02878	COG0577	efflux transmembrane transporter activity
CO731_02880	COG0384	phenazine biosynthesis protein PhzF
CO731_02882	COG2066	Belongs to the glutaminase family
CO731_02883	COG0628	permease
CO731_02887	COG1959	2 iron, 2 sulfur cluster binding
CO731_02888	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO731_02889	COG4208	sulfate ABC transporter
CO731_02891	COG4150	thiosulfate binding
CO731_02892	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CO731_02893	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CO731_02894	COG1797	cobyrinic acid a,c-diamide synthase activity
CO731_02896	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CO731_02908	COG3214	Protein conserved in bacteria
CO731_02909	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_02910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_02911	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_02912	COG0649	NAD binding
CO731_02913	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CO731_02914	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CO731_02915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO731_02915	COG3743	rRNA binding
CO731_02917	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CO731_02918	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_02920	COG0713	ATP synthesis coupled electron transport
CO731_02923	COG1007	ATP synthesis coupled electron transport
CO731_02928	COG0442	prolyl-tRNA aminoacylation
CO731_02930	COG1136	(ABC) transporter
CO731_02931	COG0321	lipoyl(octanoyl) transferase activity
CO731_02936	COG0789	Transcriptional regulator
CO731_02937	COG2239	Acts as a magnesium transporter
CO731_02942	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CO731_02947	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CO731_02953	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_02960	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_02960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_02962	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_02963	COG3264	Mechanosensitive ion channel
CO731_02963	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CO731_02968	COG1088	dTDP-glucose 4,6-dehydratase activity
CO731_02977	COG0583	DNA-binding transcription factor activity
CO731_02982	COG0646	methionine synthase
CO731_02982	COG1410	methionine synthase
CO731_02986	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO731_02987	COG3932	Exopolysaccharide synthesis, ExoD
CO731_02991	COG5012	cobalamin binding
CO731_02992	COG5598	trimethylamine methyltransferase
CO731_02994	COG2186	Transcriptional regulator
CO731_02995	COG2807	transmembrane transport
CO731_02996	COG2081	HI0933 family
CO731_02998	COG2304	oxidoreductase activity
CO731_03002	COG1410	methionine synthase
CO731_03002	COG0646	methionine synthase
CO731_03003	COG3665	Urea carboxylase-associated protein
CO731_03007	COG0006	proline dipeptidase activity
CO731_03009	COG0251	oxidation-reduction process
CO731_03010	COG5598	trimethylamine methyltransferase
CO731_03018	COG1960	acyl-CoA dehydrogenase activity
CO731_03019	COG1492	cobalamin metabolic process
CO731_03026	COG0601	transmembrane transport
CO731_03027	COG0747	negative chemotaxis
CO731_03028	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_03034	COG0243	molybdopterin cofactor binding
CO731_03035	COG0437	4 iron, 4 sulfur cluster binding
CO731_03037	COG1560	Kdo2-lipid A biosynthetic process
CO731_03039	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO731_03040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO731_03041	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO731_03046	COG1858	cytochrome C peroxidase
CO731_03047	COG1522	sequence-specific DNA binding
CO731_03055	COG3720	iron ion transport
CO731_03056	COG4558	Periplasmic binding protein
CO731_03057	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_03058	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CO731_03059	COG2514	catechol 2,3-dioxygenase activity
CO731_03060	COG0037	tRNA processing
CO731_03061	COG2814	Major facilitator Superfamily
CO731_03062	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CO731_03064	COG2226	methyltransferase
CO731_03066	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO731_03069	COG0047	phosphoribosylformylglycinamidine synthase activity
CO731_03071	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO731_03072	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO731_03076	COG1959	2 iron, 2 sulfur cluster binding
CO731_03078	COG2733	membrane
CO731_03087	COG1304	FMN binding
CO731_03088	COG2832	Protein of unknown function (DUF454)
CO731_03094	COG2948	multi-organism process
CO731_03097	COG3846	protein secretion by the type IV secretion system
CO731_03100	COG3451	type IV secretory pathway VirB4
CO731_03103	COG4962	Type ii secretion system protein e
CO731_03109	COG3436	PFAM IS66 Orf2 family protein
CO731_03110	COG2433	Pfam Transposase IS66
CO731_03111	COG0741	lytic transglycosylase activity
CO731_03119	COG3608	succinylglutamate desuccinylase aspartoacylase
CO731_03120	COG1126	abc transporter atp-binding protein
CO731_03121	COG4597	amino acid ABC transporter
CO731_03122	COG0765	amino acid transport
CO731_03123	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_03126	COG2197	response regulator
CO731_03127	COG3916	Acyl-homoserine-lactone synthase
CO731_03128	COG5489	Protein of unknown function (DUF736)
CO731_03135	COG1733	regulation of RNA biosynthetic process
CO731_03137	COG0583	DNA-binding transcription factor activity
CO731_03141	COG0456	acetyltransferase
CO731_03143	COG3852	Histidine kinase
CO731_03148	COG2801	Transposase and inactivated derivatives
CO731_03148	COG3415	Transposase
CO731_03152	COG0573	inorganic phosphate transmembrane transporter activity
CO731_03153	COG0581	inorganic phosphate transmembrane transporter activity
CO731_03154	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO731_03155	COG0704	Plays a role in the regulation of phosphate uptake
CO731_03156	COG0745	RESPONSE REGULATOR receiver
CO731_03160	COG0431	NADPH-dependent FMN reductase
CO731_03161	COG1393	Belongs to the ArsC family
CO731_03162	COG0798	PFAM Bile acid sodium symporter
CO731_03165	COG0640	Transcriptional regulator
CO731_03168	COG1793	dna ligase
CO731_03174	COG2217	Heavy metal translocating P-type atpase
CO731_03179	COG1136	(ABC) transporter
CO731_03184	COG0071	Belongs to the small heat shock protein (HSP20) family
CO731_03195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO731_03203	COG0045	succinate-CoA ligase (ADP-forming) activity
CO731_03203	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO731_03203	COG1042	CoA-binding domain protein
CO731_03205	COG2217	Heavy metal translocating P-type atpase
CO731_03209	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CO731_03214	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CO731_03215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO731_03216	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CO731_03218	COG0745	RESPONSE REGULATOR receiver
CO731_03219	COG2205	protein histidine kinase activity
CO731_03221	COG3415	Transposase
CO731_03221	COG2801	Transposase and inactivated derivatives
CO731_03222	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO731_03225	COG2235	arginine
CO731_03229	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO731_03232	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CO731_03233	COG2205	protein histidine kinase activity
CO731_03233	COG2202	Pas domain
CO731_03236	COG1573	uracil-dna glycosylase
CO731_03237	COG1522	sequence-specific DNA binding
CO731_03239	COG2084	Dehydrogenase
CO731_03244	COG0746	molybdenum cofactor guanylyltransferase activity
CO731_03247	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CO731_03251	COG1846	Transcriptional regulator
CO731_03254	COG2989	Protein conserved in bacteria
CO731_03257	COG0546	phosphoglycolate phosphatase activity
CO731_03258	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO731_03261	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CO731_03264	COG2199	diguanylate cyclase activity
CO731_03266	COG3384	dioxygenase
CO731_03267	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO731_03274	COG0740	serine-type endopeptidase activity
CO731_03276	COG0640	Transcriptional regulator
CO731_03277	COG1132	(ABC) transporter
CO731_03278	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO731_03280	COG0280	phosphate acetyltransferase
CO731_03280	COG0281	malic enzyme
CO731_03284	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_03285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CO731_03286	COG1127	ABC transporter
CO731_03288	COG3218	ABC-type transport auxiliary lipoprotein component
CO731_03288	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CO731_03291	COG0633	Ferredoxin
CO731_03292	COG0492	ferredoxin-NADP+ reductase activity
CO731_03296	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CO731_03299	COG0784	Response regulator, receiver
CO731_03300	COG3706	GGDEF domain
CO731_03300	COG0745	RESPONSE REGULATOR receiver
CO731_03303	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO731_03304	COG2814	Major facilitator Superfamily
CO731_03307	COG0557	exoribonuclease II activity
CO731_03308	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO731_03310	COG0758	DNA mediated transformation
CO731_03311	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CO731_03312	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO731_03313	COG0540	Belongs to the ATCase OTCase family
CO731_03314	COG1960	acyl-CoA dehydrogenase activity
CO731_03316	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO731_03317	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CO731_03319	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO731_03320	COG0154	amidase activity
CO731_03322	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CO731_03324	COG1760	l-serine dehydratase
CO731_03327	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CO731_03330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CO731_03332	COG3706	GGDEF domain
CO731_03337	COG0537	adenosine 5'-monophosphoramidase activity
CO731_03340	COG0584	glycerophosphoryl diester phosphodiesterase
CO731_03344	COG0052	Belongs to the universal ribosomal protein uS2 family
CO731_03345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO731_03346	COG0528	UMP kinase activity
CO731_03347	COG0233	cytoplasmic translational termination
CO731_03348	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO731_03349	COG0575	Belongs to the CDS family
CO731_03350	COG0750	zinc metalloprotease
CO731_03351	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CO731_03352	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CO731_03353	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO731_03354	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CO731_03355	COG3494	Protein of unknown function (DUF1009)
CO731_03356	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CO731_03357	COG0372	Belongs to the citrate synthase family
CO731_03358	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO731_03360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO731_03361	COG0303	'Molybdopterin
CO731_03362	COG0315	cyclic pyranopterin monophosphate synthase activity
CO731_03363	COG0134	indole-3-glycerol-phosphate synthase activity
CO731_03364	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CO731_03366	COG0149	triose-phosphate isomerase activity
CO731_03369	COG0504	CTP synthase activity
CO731_03372	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CO731_03376	COG0148	phosphopyruvate hydratase activity
CO731_03377	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CO731_03378	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO731_03379	COG0022	dehydrogenase e1 component
CO731_03379	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_03380	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_03382	COG0456	acetyltransferase
CO731_03383	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO731_03385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CO731_03386	COG2867	negative regulation of translational initiation
CO731_03388	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CO731_03388	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CO731_03390	COG3852	Histidine kinase
CO731_03391	COG2204	response regulator
CO731_03392	COG5000	phosphorelay sensor kinase activity
CO731_03393	COG2204	response regulator
CO731_03394	COG0569	domain protein
CO731_03395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_03396	COG1923	regulation of RNA biosynthetic process
CO731_03397	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO731_03398	COG3956	TIGRFAM MazG family protein
CO731_03399	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO731_03401	COG0546	phosphoglycolate phosphatase activity
CO731_03403	COG0174	glutamine synthetase
CO731_03405	COG0346	lactoylglutathione lyase activity
CO731_03408	COG0174	glutamine synthetase
CO731_03409	COG0347	Belongs to the P(II) protein family
CO731_03410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CO731_03410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO731_03413	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO731_03415	COG1794	racemase activity, acting on amino acids and derivatives
CO731_03418	COG0671	phosphoesterase, PA-phosphatase related
CO731_03419	COG0629	single-stranded DNA binding
CO731_03422	COG2095	MarC family integral membrane protein
CO731_03423	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO731_03425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO731_03426	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CO731_03427	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CO731_03429	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CO731_03430	COG0343	queuine tRNA-ribosyltransferase activity
CO731_03437	COG2308	Evidence 4 Homologs of previously reported genes of
CO731_03449	COG0785	Cytochrome C biogenesis protein
CO731_03450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO731_03451	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO731_03453	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO731_03455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO731_03458	COG4166	transmembrane transport
CO731_03461	COG0679	Auxin Efflux Carrier
CO731_03462	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CO731_03463	COG1183	phosphatidylcholine synthase activity
CO731_03469	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO731_03470	COG0861	Integral membrane protein TerC family
CO731_03472	COG0739	heme binding
CO731_03476	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_03476	COG2885	chlorophyll binding
CO731_03478	COG3501	Rhs element vgr protein
CO731_03487	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_03487	COG2885	chlorophyll binding
CO731_03511	COG1686	Belongs to the peptidase S11 family
CO731_03512	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO731_03515	COG0084	hydrolase, TatD family'
CO731_03516	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO731_03516	COG0321	lipoyl(octanoyl) transferase activity
CO731_03518	COG2826	transposase and inactivated derivatives, IS30 family
CO731_03519	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CO731_03520	COG4638	Rieske (2fe-2S)
CO731_03521	COG0583	DNA-binding transcription factor activity
CO731_03522	COG0747	negative chemotaxis
CO731_03525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_03526	COG0601	transmembrane transport
CO731_03527	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_03531	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_03531	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_03532	COG4311	Sarcosine oxidase, delta subunit
CO731_03533	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_03538	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CO731_03539	COG0667	Aldo Keto reductase
CO731_03541	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_03548	COG3453	Protein conserved in bacteria
CO731_03548	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_03549	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_03549	COG3453	Protein conserved in bacteria
CO731_03550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO731_03552	COG0203	ribosomal protein L17
CO731_03553	COG0202	RNA polymerase activity
CO731_03554	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO731_03555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO731_03556	COG0563	adenylate kinase activity
CO731_03558	COG0200	Binds to the 23S rRNA
CO731_03559	COG1841	ribosomal large subunit assembly
CO731_03560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO731_03561	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO731_03562	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO731_03563	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO731_03564	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO731_03565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO731_03566	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO731_03567	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO731_03568	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO731_03569	COG0255	Belongs to the universal ribosomal protein uL29 family
CO731_03570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO731_03571	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO731_03572	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO731_03573	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO731_03574	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO731_03575	COG0089	rRNA binding
CO731_03576	COG0088	Forms part of the polypeptide exit tunnel
CO731_03577	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO731_03578	COG0051	transcription antitermination factor activity, RNA binding
CO731_03579	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO731_03580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO731_03581	COG0049	tRNA binding
CO731_03582	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO731_03584	COG0531	amino acid
CO731_03585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO731_03586	COG0085	RNA polymerase activity
CO731_03587	COG0222	ribosome binding
CO731_03588	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO731_03589	COG0081	regulation of translation
CO731_03590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO731_03596	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO731_03599	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO731_03601	COG2084	Dehydrogenase
CO731_03602	COG3622	Belongs to the hyi family
CO731_03603	COG3960	tartronate-semialdehyde synthase activity
CO731_03606	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO731_03609	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO731_03611	COG2885	chlorophyll binding
CO731_03616	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CO731_03618	COG0860	N-Acetylmuramoyl-L-alanine amidase
CO731_03619	COG1530	ribonuclease E activity
CO731_03620	COG4957	zinc ion binding
CO731_03623	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CO731_03626	COG0737	Belongs to the 5'-nucleotidase family
CO731_03627	COG1522	sequence-specific DNA binding
CO731_03628	COG0686	Belongs to the AlaDH PNT family
CO731_03629	COG2885	chlorophyll binding
CO731_03629	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_03633	COG2897	thiosulfate sulfurtransferase activity
CO731_03634	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO731_03635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CO731_03636	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_03638	COG0513	Belongs to the DEAD box helicase family
CO731_03643	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CO731_03645	COG3106	COG3106 Predicted ATPase
CO731_03646	COG3768	UPF0283 membrane protein
CO731_03649	COG0475	glutathione-regulated potassium exporter activity
CO731_03649	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CO731_03652	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO731_03654	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_03657	COG0587	DNA-directed DNA polymerase activity
CO731_03658	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CO731_03660	COG1671	Belongs to the UPF0178 family
CO731_03663	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CO731_03664	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_03665	COG0509	glycine decarboxylation via glycine cleavage system
CO731_03666	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CO731_03666	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CO731_03668	COG0187	DNA topoisomerase II activity
CO731_03671	COG2301	Belongs to the HpcH HpaI aldolase family
CO731_03672	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_03673	COG0778	Nitroreductase
CO731_03675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO731_03677	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CO731_03679	COG0583	DNA-binding transcription factor activity
CO731_03681	COG0302	gtp cyclohydrolase
CO731_03682	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CO731_03683	COG1752	Esterase of the alpha-beta hydrolase superfamily
CO731_03684	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO731_03685	COG1494	fructose-1,6-bisphosphatase
CO731_03687	COG0436	Aminotransferase
CO731_03689	COG3243	poly(R)-hydroxyalkanoic acid synthase
CO731_03699	COG1802	Transcriptional regulator
CO731_03701	COG2801	Transposase and inactivated derivatives
CO731_03701	COG3415	Transposase
CO731_03702	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_03704	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_03705	COG1802	Transcriptional regulator
CO731_03706	COG2824	Alkylphosphonate utilization operon protein PhnA
CO731_03708	COG0024	Methionine aminopeptidase
CO731_03709	COG2003	Belongs to the UPF0758 family
CO731_03718	COG2197	response regulator
CO731_03722	COG3415	Transposase
CO731_03722	COG2801	Transposase and inactivated derivatives
CO731_03723	COG3846	protein secretion by the type IV secretion system
CO731_03726	COG2948	multi-organism process
CO731_03729	COG2003	Belongs to the UPF0758 family
CO731_03730	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO731_03732	COG0438	transferase activity, transferring glycosyl groups
CO731_03738	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CO731_03739	COG0519	Catalyzes the synthesis of GMP from XMP
CO731_03746	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CO731_03747	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CO731_03748	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO731_03749	COG0805	protein transport
CO731_03750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CO731_03751	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CO731_03753	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO731_03754	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO731_03755	COG1472	Belongs to the glycosyl hydrolase 3 family
CO731_03757	COG0018	arginyl-trna synthetase
CO731_03758	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CO731_03762	COG2233	PERMEase
CO731_03763	COG0708	Exodeoxyribonuclease III
CO731_03764	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CO731_03766	COG0525	valine-tRNA ligase activity
CO731_03769	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CO731_03773	COG1473	amidohydrolase
CO731_03779	COG0436	Aminotransferase
CO731_03782	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CO731_03783	COG0511	ligase activity, forming carbon-carbon bonds
CO731_03785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CO731_03790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CO731_03791	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CO731_03793	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO731_03794	COG3811	Belongs to the UPF0386 family
CO731_03795	COG0516	GMP reductase activity
CO731_03795	COG0517	IMP dehydrogenase activity
CO731_03804	COG1024	Enoyl-CoA hydratase
CO731_03808	COG1278	Cold shock
CO731_03809	COG0346	lactoylglutathione lyase activity
CO731_03811	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO731_03812	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO731_03815	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CO731_03828	COG1546	Belongs to the CinA family
CO731_03828	COG1058	Belongs to the CinA family
CO731_03830	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CO731_03832	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO731_03835	COG1607	acyl-coa hydrolase
CO731_03837	COG2855	membrane
CO731_03838	COG0583	DNA-binding transcription factor activity
CO731_03843	COG0596	Alpha beta hydrolase
CO731_03843	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_03850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO731_03851	COG3608	succinylglutamate desuccinylase aspartoacylase
CO731_03851	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CO731_03857	COG3191	aminopeptidase activity
CO731_03860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO731_03861	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO731_03863	COG1733	regulation of RNA biosynthetic process
CO731_03866	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CO731_03868	COG0538	isocitrate dehydrogenase activity
CO731_03870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO731_03871	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO731_03872	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_03873	COG2313	pseudouridylate synthase activity
CO731_03876	COG0316	Belongs to the HesB IscA family
CO731_03877	COG2151	metal-sulfur cluster biosynthetic enzyme
CO731_03878	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO731_03879	COG0719	Fe-S assembly protein
CO731_03880	COG0396	ATPase activity
CO731_03882	COG0719	Fe-S assembly protein
CO731_03883	COG1104	cysteine desulfurase activity
CO731_03884	COG2945	thiolester hydrolase activity
CO731_03888	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CO731_03889	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO731_03891	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CO731_03892	COG0739	heme binding
CO731_03895	COG0720	synthase
CO731_03897	COG5001	Diguanylate cyclase
CO731_03901	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CO731_03903	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CO731_03904	COG0156	8-amino-7-oxononanoate synthase activity
CO731_03906	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CO731_03907	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO731_03911	COG4608	Belongs to the ABC transporter superfamily
CO731_03912	COG0444	Belongs to the ABC transporter superfamily
CO731_03914	COG0601	transmembrane transport
CO731_03915	COG1396	sequence-specific DNA binding
CO731_03916	COG0747	negative chemotaxis
CO731_03919	COG0776	regulation of translation
CO731_03921	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO731_03922	COG0740	serine-type endopeptidase activity
CO731_03931	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO731_03932	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO731_03934	COG0584	glycerophosphoryl diester phosphodiesterase
CO731_03935	COG0010	Belongs to the arginase family
CO731_03938	COG1612	heme a metabolic process
CO731_03944	COG0438	transferase activity, transferring glycosyl groups
CO731_03945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO731_03953	COG0776	regulation of translation
CO731_03954	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO731_03955	COG0416	fatty acid biosynthetic process
CO731_03958	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CO731_03959	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CO731_03961	COG1174	glycine betaine transport
CO731_03962	COG1125	glycine betaine transport
CO731_03963	COG1174	glycine betaine transport
CO731_03964	COG1732	Glycine betaine
CO731_03965	COG2814	Major facilitator Superfamily
CO731_03966	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO731_03967	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CO731_03969	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO731_03969	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO731_03970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO731_03971	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO731_03972	COG2989	Protein conserved in bacteria
CO731_03975	COG1024	Enoyl-CoA hydratase
CO731_03976	COG0113	porphobilinogen synthase activity
CO731_03978	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CO731_03980	COG0628	permease
CO731_03981	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO731_03983	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO731_03986	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CO731_03991	COG0477	Major facilitator Superfamily
CO731_03992	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CO731_03997	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CO731_04002	COG3842	ATPase activity
CO731_04004	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_04011	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CO731_04017	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CO731_04020	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO731_04022	COG1744	ABC transporter substrate-binding protein PnrA-like
CO731_04024	COG2169	Transcriptional regulator
CO731_04025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CO731_04027	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO731_04030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_04031	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO731_04031	COG2111	Na H antiporter
CO731_04032	COG1006	Multisubunit Na H antiporter MnhC subunit
CO731_04033	COG0651	ATP synthesis coupled electron transport
CO731_04034	COG1863	multisubunit Na H antiporter MnhE subunit
CO731_04035	COG2212	antiporter activity
CO731_04036	COG1320	monovalent cation:proton antiporter activity
CO731_04038	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CO731_04039	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_04041	COG0367	asparagine synthase
CO731_04042	COG2890	protein-(glutamine-N5) methyltransferase activity
CO731_04052	COG1846	Transcriptional regulator
CO731_04052	COG1940	carbohydrate kinase activity
CO731_04059	COG2252	PERMEase
CO731_04063	COG3842	ATPase activity
CO731_04065	COG0395	ABC-type sugar transport system, permease component
CO731_04068	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO731_04070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CO731_04071	COG1132	(ABC) transporter
CO731_04072	COG3459	Glycosyltransferase 36 associated
CO731_04075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CO731_04077	COG2986	histidine ammonia-lyase
CO731_04078	COG1228	amidohydrolase
CO731_04081	COG0251	oxidation-reduction process
CO731_04082	COG1121	(ABC) transporter
CO731_04083	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO731_04084	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO731_04091	COG1234	tRNA 3'-trailer cleavage
CO731_04093	COG1063	alcohol dehydrogenase
CO731_04096	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_04098	COG1960	acyl-CoA dehydrogenase activity
CO731_04100	COG1902	pentaerythritol trinitrate reductase activity
CO731_04100	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_04101	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CO731_04104	COG5598	trimethylamine methyltransferase
CO731_04105	COG0583	DNA-binding transcription factor activity
CO731_04106	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CO731_04108	COG1663	tetraacyldisaccharide 4'-kinase activity
CO731_04109	COG1519	Transferase
CO731_04112	COG0483	inositol monophosphate 1-phosphatase activity
CO731_04113	COG0312	modulator of DNA gyrase
CO731_04116	COG0612	Peptidase, M16
CO731_04117	COG0612	Peptidase, M16
CO731_04119	COG0742	ribosomal rna small subunit methyltransferase
CO731_04121	COG0590	tRNA wobble adenosine to inosine editing
CO731_04123	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO731_04126	COG0196	riboflavin kinase activity
CO731_04129	COG2814	Major facilitator Superfamily
CO731_04132	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CO731_04132	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CO731_04134	COG0459	protein refolding
CO731_04136	COG3237	CsbD-like
CO731_04137	COG0114	fumarate hydratase activity
CO731_04138	COG2259	Doxx family
CO731_04141	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CO731_04143	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CO731_04145	COG1126	abc transporter atp-binding protein
CO731_04146	COG0765	amino acid transport
CO731_04147	COG4597	amino acid ABC transporter
CO731_04148	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_04150	COG0626	cystathionine gamma-synthase activity
CO731_04158	COG2186	Transcriptional regulator
CO731_04159	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_04160	COG0129	dihydroxy-acid dehydratase activity
CO731_04161	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CO731_04162	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CO731_04163	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CO731_04164	COG3734	2-keto-3-deoxy-galactonokinase
CO731_04165	COG0800	Aldolase
CO731_04169	COG0628	permease
CO731_04171	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO731_04172	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO731_04175	COG0243	molybdopterin cofactor binding
CO731_04176	COG0488	(ABC) transporter
CO731_04180	COG0105	UTP biosynthetic process
CO731_04181	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CO731_04182	COG0314	molybdopterin synthase activity
CO731_04185	COG0322	excinuclease ABC activity
CO731_04186	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_04188	COG0625	glutathione transferase activity
CO731_04191	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CO731_04196	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO731_04201	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CO731_04202	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO731_04203	COG0194	GDP metabolic process
CO731_04204	COG1561	YicC-like family, N-terminal region
CO731_04205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO731_04206	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO731_04207	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO731_04209	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO731_04210	COG1368	sulfuric ester hydrolase activity
CO731_04211	COG0360	Binds together with S18 to 16S ribosomal RNA
CO731_04213	COG0359	binds to the 23S rRNA
CO731_04214	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CO731_04215	COG1742	UPF0060 membrane protein
CO731_04217	COG0305	Participates in initiation and elongation during chromosome replication
CO731_04221	COG2814	Major facilitator Superfamily
CO731_04222	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CO731_04224	COG4221	oxidoreductase activity
CO731_04225	COG0471	metal ion transport
CO731_04225	COG3273	potassium ion transport
CO731_04229	COG0204	Acyl-transferase
CO731_04229	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_04231	COG0688	phosphatidylethanolamine metabolic process
CO731_04234	COG5265	(ABC) transporter
CO731_04236	COG1652	LysM domain
CO731_04239	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CO731_04245	COG2852	Protein conserved in bacteria
CO731_04246	COG0215	cysteine-tRNA ligase activity
CO731_04255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO731_04257	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CO731_04262	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO731_04264	COG0640	Transcriptional regulator
CO731_04265	COG0189	ligase activity
CO731_04266	COG0456	acetyltransferase
CO731_04268	COG1595	DNA-templated transcription, initiation
CO731_04270	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CO731_04275	COG1381	Involved in DNA repair and RecF pathway recombination
CO731_04279	COG2814	Major facilitator Superfamily
CO731_04281	COG4221	oxidoreductase activity
CO731_04287	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO731_04288	COG1418	mRNA catabolic process
CO731_04290	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO731_04296	COG0300	oxidoreductase activity
CO731_04298	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO731_04299	COG0571	ribonuclease III activity
CO731_04300	COG0681	Belongs to the peptidase S26 family
CO731_04301	COG0736	holo-[acyl-carrier-protein] synthase activity
CO731_04302	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO731_04304	COG1758	RNA polymerase activity
CO731_04307	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO731_04308	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_04309	COG0741	lytic transglycosylase activity
CO731_04310	COG2945	thiolester hydrolase activity
CO731_04310	COG0596	Alpha beta hydrolase
CO731_04317	COG4453	Protein conserved in bacteria
CO731_04318	COG5489	Protein of unknown function (DUF736)
CO731_04325	COG1192	Involved in chromosome partitioning
CO731_04328	COG0681	Belongs to the peptidase S26 family
CO731_04330	COG0741	lytic transglycosylase activity
CO731_04333	COG0596	Alpha beta hydrolase
CO731_04333	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_04334	COG0583	DNA-binding transcription factor activity
CO731_04337	COG4962	Type ii secretion system protein e
CO731_04340	COG3451	type IV secretory pathway VirB4
CO731_04343	COG3846	protein secretion by the type IV secretion system
CO731_04346	COG2948	multi-organism process
CO731_04348	COG0583	DNA-binding transcription factor activity
CO731_04351	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_04355	COG4991	sh3 domain protein
CO731_04365	COG4974	Belongs to the 'phage' integrase family
CO731_04368	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CO731_04369	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_04371	COG1960	acyl-CoA dehydrogenase activity
CO731_04375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CO731_04378	COG0450	alkyl hydroperoxide reductase
CO731_04382	COG0625	glutathione transferase activity
CO731_04385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CO731_04390	COG1573	uracil-dna glycosylase
CO731_04395	COG0308	aminopeptidase N
CO731_04396	COG2205	protein histidine kinase activity
CO731_04396	COG2202	Pas domain
CO731_04398	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CO731_04399	COG2205	protein histidine kinase activity
CO731_04400	COG0745	RESPONSE REGULATOR receiver
CO731_04401	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO731_04402	COG3088	subunit of a heme lyase
CO731_04403	COG1138	Cytochrome C-type biogenesis protein
CO731_04404	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CO731_04405	COG4235	cytochrome complex assembly
CO731_04408	COG0745	RESPONSE REGULATOR receiver
CO731_04413	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CO731_04420	COG2205	protein histidine kinase activity
CO731_04422	COG2166	iron-sulfur cluster assembly
CO731_04424	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO731_04426	COG4957	zinc ion binding
CO731_04429	COG2010	Cytochrome c
CO731_04431	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CO731_04432	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_04434	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_04435	COG0433	COG0433 Predicted ATPase
CO731_04437	COG3654	unkown
CO731_04438	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_04440	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_04441	COG0183	Belongs to the thiolase family
CO731_04442	COG1309	transcriptional regulator
CO731_04443	COG3119	arylsulfatase activity
CO731_04445	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CO731_04446	COG1012	belongs to the aldehyde dehydrogenase family
CO731_04447	COG0662	Cupin 2, conserved barrel domain protein
CO731_04447	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CO731_04448	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO731_04471	COG2801	Transposase and inactivated derivatives
CO731_04471	COG3415	Transposase
CO731_04472	COG0366	Alpha amylase catalytic
CO731_04473	COG1523	belongs to the glycosyl hydrolase 13 family
CO731_04474	COG0033	Phosphoglucomutase
CO731_04475	COG0297	glycogen (starch) synthase activity
CO731_04476	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO731_04477	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CO731_04478	COG0058	SHG alpha-glucan phosphorylase activity
CO731_04486	COG1218	3'(2'),5'-bisphosphate nucleotidase
CO731_04488	COG0175	sulfate reduction
CO731_04494	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_04496	COG0574	Belongs to the PEP-utilizing enzyme family
CO731_04496	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO731_04502	COG0189	ligase activity
CO731_04508	COG0829	nickel cation binding
CO731_04509	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CO731_04510	COG0804	urea catabolic process
CO731_04511	COG0831	urea catabolic process
CO731_04511	COG0832	Belongs to the urease beta subunit family
CO731_04512	COG0830	nickel cation binding
CO731_04521	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_04524	COG0010	Belongs to the arginase family
CO731_04532	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_04533	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_04535	COG1196	nuclear chromosome segregation
CO731_04536	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CO731_04538	COG1194	a g-specific adenine glycosylase
CO731_04539	COG1011	Hydrolase
CO731_04540	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CO731_04541	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_04544	COG0612	Peptidase, M16
CO731_04545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO731_04547	COG1678	Uncharacterized ACR, COG1678
CO731_04549	COG0678	peroxiredoxin activity
CO731_04550	COG0328	RNA-DNA hybrid ribonuclease activity
CO731_04551	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CO731_04552	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CO731_04553	COG3346	SURF1 family
CO731_04557	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CO731_04559	COG0109	protoheme IX farnesyltransferase activity
CO731_04560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CO731_04561	COG1565	acr, cog1565
CO731_04561	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CO731_04565	COG0312	modulator of DNA gyrase
CO731_04566	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO731_04568	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CO731_04569	COG1741	Belongs to the pirin family
CO731_04571	COG1722	exodeoxyribonuclease VII activity
CO731_04572	COG0123	including yeast histone deacetylase and acetoin utilization protein
CO731_04573	COG1309	transcriptional regulator
CO731_04578	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CO731_04580	COG0406	alpha-ribazole phosphatase activity
CO731_04581	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO731_04582	COG0484	heat shock protein binding
CO731_04584	COG0259	pyridoxamine-phosphate oxidase activity
CO731_04586	COG1960	acyl-CoA dehydrogenase activity
CO731_04589	COG0151	Belongs to the GarS family
CO731_04590	COG4115	mRNA cleavage
CO731_04595	COG0009	L-threonylcarbamoyladenylate synthase
CO731_04598	COG0751	glycine-tRNA ligase activity
CO731_04600	COG0752	glycyl-tRNA synthetase alpha subunit
CO731_04602	COG0142	geranyltranstransferase activity
CO731_04607	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CO731_04608	COG0521	Mo-molybdopterin cofactor biosynthetic process
CO731_04612	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO731_04613	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO731_04614	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO731_04615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO731_04616	COG0356	it plays a direct role in the translocation of protons across the membrane
CO731_04619	COG1160	GTP binding
CO731_04622	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CO731_04623	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CO731_04625	COG0583	DNA-binding transcription factor activity
CO731_04626	COG1393	Belongs to the ArsC family
CO731_04627	COG1846	Transcriptional regulator
CO731_04632	COG0640	Transcriptional regulator
CO731_04633	COG0402	S-adenosylhomocysteine deaminase activity
CO731_04635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_04636	COG4608	Belongs to the ABC transporter superfamily
CO731_04637	COG0444	Belongs to the ABC transporter superfamily
CO731_04638	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_04642	COG0402	S-adenosylhomocysteine deaminase activity
CO731_04644	COG0494	nUDIX hydrolase
CO731_04645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_04646	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CO731_04649	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CO731_04652	COG0561	phosphatase activity
CO731_04655	COG2176	DNA-directed DNA polymerase activity
CO731_04656	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO731_04657	COG0210	DNA helicase
CO731_04663	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CO731_04664	COG1205	dead DEAH box helicase
CO731_04664	COG1111	helicase
CO731_04668	COG1475	DNA binding
CO731_04675	COG5489	Protein of unknown function (DUF736)
CO731_04681	COG1192	Involved in chromosome partitioning
CO731_04690	COG4962	Type ii secretion system protein e
CO731_04691	COG3838	Conjugal transfer protein Trbc
CO731_04693	COG3451	type IV secretory pathway VirB4
CO731_04696	COG3846	protein secretion by the type IV secretion system
CO731_04699	COG2948	multi-organism process
CO731_04711	COG1968	undecaprenyl-diphosphatase activity
CO731_04712	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO731_04718	COG0148	phosphopyruvate hydratase activity
CO731_04719	COG0588	phosphoglycerate mutase activity
CO731_04721	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO731_04723	COG0038	chloride channel
CO731_04731	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CO731_04733	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CO731_04735	COG0583	DNA-binding transcription factor activity
CO731_04736	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CO731_04737	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CO731_04738	COG0124	histidyl-tRNA synthetase
CO731_04741	COG2818	Glycosylase
CO731_04742	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_04744	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO731_04745	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_04746	COG0247	lactate metabolic process
CO731_04750	COG0277	FAD linked oxidase domain protein
CO731_04752	COG2186	Transcriptional regulator
CO731_04760	COG1309	transcriptional regulator
CO731_04764	COG0583	DNA-binding transcription factor activity
CO731_04765	COG1570	exodeoxyribonuclease VII activity
CO731_04767	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_04768	COG1178	ABC-type Fe3 transport system permease component
CO731_04769	COG1840	ABC-type Fe3 transport system, periplasmic component
CO731_04770	COG2205	protein histidine kinase activity
CO731_04771	COG5490	Phasin protein
CO731_04779	COG0443	Heat shock 70 kDa protein
CO731_04782	COG1074	ATP-dependent DNA helicase activity
CO731_04785	COG2801	Transposase and inactivated derivatives
CO731_04785	COG3415	Transposase
CO731_04791	COG2224	Isocitrate lyase
CO731_04795	COG0174	glutamine synthetase
CO731_04797	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_04801	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CO731_04802	COG0363	glucosamine-6-phosphate deaminase activity
CO731_04803	COG0129	dihydroxy-acid dehydratase activity
CO731_04807	COG0488	(ABC) transporter
CO731_04810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO731_04814	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CO731_04821	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CO731_04822	COG4149	molybdate abc transporter
CO731_04823	COG0725	ABC transporter, periplasmic molybdate-binding protein
CO731_04824	COG0730	response to heat
CO731_04825	COG0183	Belongs to the thiolase family
CO731_04826	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CO731_04827	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CO731_04828	COG1414	Transcriptional regulator
CO731_04830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO731_04870	COG1783	phage Terminase large subunit
CO731_04876	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO731_04887	COG3415	Transposase
CO731_04887	COG2801	Transposase and inactivated derivatives
CO731_04913	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO731_04916	COG5328	Belongs to the UPF0262 family
CO731_04918	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO731_04919	COG0424	maF-like protein
CO731_04920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CO731_04924	COG4974	Belongs to the 'phage' integrase family
CO731_04929	COG3706	GGDEF domain
CO731_04960	COG4626	Terminase
CO731_04960	COG1802	Transcriptional regulator
CO731_04970	COG0328	RNA-DNA hybrid ribonuclease activity
CO731_04984	COG0582	viral genome integration into host DNA
CO731_04985	COG3300	MHYT domain
CO731_04985	COG5001	Diguanylate cyclase
CO731_04987	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_04988	COG2186	Transcriptional regulator
CO731_04995	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO731_04996	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_05001	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_05003	COG0251	oxidation-reduction process
CO731_05005	COG0765	amino acid transport
CO731_05006	COG0765	amino acid transport
CO731_05012	COG1120	ATPase activity
CO731_05013	COG3585	molybdate ion transport
CO731_05014	COG1720	tRNA m6t6A37 methyltransferase activity
CO731_05017	COG4215	(ABC) transporter
CO731_05018	COG0765	amino acid transport
CO731_05019	COG3457	Alanine racemase
CO731_05020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_05022	COG0156	8-amino-7-oxononanoate synthase activity
CO731_05023	COG0436	Aminotransferase
CO731_05024	COG1970	mechanosensitive ion channel activity
CO731_05025	COG0784	Response regulator, receiver
CO731_05025	COG2205	protein histidine kinase activity
CO731_05029	COG0167	dihydroorotate dehydrogenase activity
CO731_05031	COG0123	including yeast histone deacetylase and acetoin utilization protein
CO731_05035	COG0717	Belongs to the dCTP deaminase family
CO731_05037	COG2967	ApaG domain
CO731_05038	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CO731_05039	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO731_05040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO731_05042	COG0598	Magnesium transport protein CorA
CO731_05043	COG0704	Plays a role in the regulation of phosphate uptake
CO731_05044	COG5002	protein histidine kinase activity
CO731_05045	COG2326	polyphosphate kinase activity
CO731_05055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_05057	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CO731_05059	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO731_05061	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_05061	COG1024	Enoyl-CoA hydratase
CO731_05062	COG0183	Belongs to the thiolase family
CO731_05063	COG1960	acyl-CoA dehydrogenase activity
CO731_05065	COG1960	acyl-CoA dehydrogenase activity
CO731_05066	COG0789	Transcriptional regulator
CO731_05068	COG0730	response to heat
CO731_05071	COG1201	RNA secondary structure unwinding
CO731_05075	COG1793	dna ligase
CO731_05131	COG3422	double-strand break repair
CO731_05134	COG0444	Belongs to the ABC transporter superfamily
CO731_05135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_05137	COG0747	negative chemotaxis
CO731_05138	COG4608	Belongs to the ABC transporter superfamily
CO731_05139	COG0444	Belongs to the ABC transporter superfamily
CO731_05140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_05141	COG0601	transmembrane transport
CO731_05142	COG0747	negative chemotaxis
CO731_05143	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_05145	COG0129	dihydroxy-acid dehydratase activity
CO731_05154	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO731_05155	COG0166	Belongs to the GPI family
CO731_05157	COG0583	DNA-binding transcription factor activity
CO731_05158	COG2814	Major facilitator Superfamily
CO731_05159	COG0489	protein tyrosine kinase activity
CO731_05164	COG0583	DNA-binding transcription factor activity
CO731_05167	COG3383	formate dehydrogenase (NAD+) activity
CO731_05168	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CO731_05170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_05176	COG1349	DNA-binding transcription factor activity
CO731_05179	COG2340	Cysteine-rich secretory protein family
CO731_05180	COG0697	spore germination
CO731_05182	COG0402	S-adenosylhomocysteine deaminase activity
CO731_05184	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO731_05187	COG1132	(ABC) transporter
CO731_05188	COG1012	belongs to the aldehyde dehydrogenase family
CO731_05189	COG0288	reversible hydration of carbon dioxide
CO731_05193	COG1346	cytolysis
CO731_05197	COG1733	regulation of RNA biosynthetic process
CO731_05201	COG0594	ribonuclease P activity
CO731_05202	COG0706	membrane insertase activity
CO731_05204	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO731_05205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_05206	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CO731_05209	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CO731_05212	COG3186	Phenylalanine-4-hydroxylase
CO731_05214	COG3706	GGDEF domain
CO731_05216	COG3739	integral membrane protein
CO731_05218	COG2171	N-acyltransferase activity
CO731_05219	COG3152	Membrane
CO731_05220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_05222	COG0101	tRNA pseudouridine synthase activity
CO731_05224	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO731_05225	COG0242	peptide deformylase activity
CO731_05229	COG2076	Multidrug Resistance protein
CO731_05232	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CO731_05234	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO731_05235	COG3409	Peptidoglycan-binding domain 1 protein
CO731_05235	COG3773	Cell wall hydrolase
CO731_05237	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CO731_05238	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO731_05240	COG2816	NAD+ diphosphatase activity
CO731_05241	COG1846	Transcriptional regulator
CO731_05241	COG0456	acetyltransferase
CO731_05242	COG4106	trans-aconitate 2-methyltransferase activity
CO731_05243	COG0077	Prephenate dehydratase
CO731_05243	COG1605	Chorismate mutase
CO731_05244	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CO731_05245	COG3474	cytochrome
CO731_05246	COG4166	transmembrane transport
CO731_05247	COG4166	transmembrane transport
CO731_05248	COG4174	ABC transporter (Permease)
CO731_05249	COG4239	(ABC) transporter, permease
CO731_05251	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CO731_05252	COG4172	Belongs to the ABC transporter superfamily
CO731_05256	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO731_05263	COG4964	Belongs to the GSP D family
CO731_05270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CO731_05271	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO731_05272	COG1024	Enoyl-CoA hydratase
CO731_05273	COG0268	Binds directly to 16S ribosomal RNA
CO731_05275	COG4208	sulfate ABC transporter
CO731_05276	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_05277	COG3842	ATPase activity
CO731_05282	COG0604	alcohol dehydrogenase
CO731_05284	COG0277	FAD linked oxidase domain protein
CO731_05287	COG1192	Involved in chromosome partitioning
CO731_05288	COG1475	DNA binding
CO731_05289	COG1414	Transcriptional regulator
CO731_05298	COG0765	amino acid transport
CO731_05299	COG0765	amino acid transport
CO731_05303	COG1126	abc transporter atp-binding protein
CO731_05304	COG0252	asparaginase activity
CO731_05305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_05307	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_05308	COG1177	transmembrane transport
CO731_05309	COG3842	ATPase activity
CO731_05311	COG0196	riboflavin kinase activity
CO731_05313	COG0625	glutathione transferase activity
CO731_05314	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CO731_05315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_05316	COG2368	4-hydroxyphenylacetate
CO731_05319	COG0583	DNA-binding transcription factor activity
CO731_05320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_05321	COG1027	Aspartate ammonia-lyase
CO731_05325	COG0242	peptide deformylase activity
CO731_05328	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_05330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_05331	COG0431	NADPH-dependent FMN reductase
CO731_05335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_05341	COG3593	DNA synthesis involved in DNA repair
CO731_05342	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CO731_05343	COG0443	Heat shock 70 kDa protein
CO731_05346	COG3415	Transposase
CO731_05346	COG2801	Transposase and inactivated derivatives
CO731_05349	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_05350	COG1177	transmembrane transport
CO731_05352	COG2072	flavoprotein involved in K transport
CO731_05355	COG3620	sequence-specific DNA binding
CO731_05357	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_05358	COG2186	Transcriptional regulator
CO731_05360	COG1129	ABC transporter
CO731_05362	COG2017	converts alpha-aldose to the beta-anomer
CO731_05363	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_05366	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_05375	COG1596	polysaccharide export
CO731_05376	COG0489	protein tyrosine kinase activity
CO731_05376	COG3206	protein involved in exopolysaccharide biosynthesis
CO731_05379	COG0438	transferase activity, transferring glycosyl groups
CO731_05381	COG0492	ferredoxin-NADP+ reductase activity
CO731_05382	COG1522	sequence-specific DNA binding
CO731_05384	COG3453	Protein conserved in bacteria
CO731_05384	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_05386	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_05387	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_05389	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_05392	COG0302	gtp cyclohydrolase
CO731_05395	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_05397	COG0402	S-adenosylhomocysteine deaminase activity
CO731_05399	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CO731_05402	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CO731_05405	COG1942	4-Oxalocrotonate Tautomerase
CO731_05408	COG0154	amidase activity
CO731_05409	COG0402	S-adenosylhomocysteine deaminase activity
CO731_05412	COG0523	cobalamin synthesis protein
CO731_05414	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_05415	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CO731_05416	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CO731_05417	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CO731_05418	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CO731_05419	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO731_05421	COG1957	nucleoside hydrolase
CO731_05422	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_05426	COG0045	succinate-CoA ligase (ADP-forming) activity
CO731_05427	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO731_05428	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO731_05429	COG2379	hydroxypyruvate reductase
CO731_05431	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CO731_05432	COG2218	PFAM glutamate synthase alpha subunit domain protein
CO731_05433	COG0069	glutamate synthase activity
CO731_05435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_05437	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_05437	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_05440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CO731_05441	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO731_05452	COG0531	amino acid
CO731_05457	COG1522	sequence-specific DNA binding
CO731_05458	COG2826	transposase and inactivated derivatives, IS30 family
CO731_05460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CO731_05462	COG0625	glutathione transferase activity
CO731_05464	COG3842	ATPase activity
CO731_05465	COG1840	ABC-type Fe3 transport system, periplasmic component
CO731_05467	COG1012	belongs to the aldehyde dehydrogenase family
CO731_05469	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CO731_05470	COG1283	sodium-dependent phosphate transmembrane transporter activity
CO731_05471	COG0583	DNA-binding transcription factor activity
CO731_05473	COG3795	YCII-related domain
CO731_05474	COG0488	(ABC) transporter
CO731_05477	COG2076	Multidrug Resistance protein
CO731_05480	COG1349	DNA-binding transcription factor activity
CO731_05483	COG4638	Rieske (2fe-2S)
CO731_05486	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_05486	COG3347	Dehydrogenase
CO731_05489	COG1129	ABC transporter
CO731_05490	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_05491	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_05494	COG1070	Carbohydrate kinase
CO731_05496	COG4952	isomerase
CO731_05497	COG3254	rhamnose metabolic process
CO731_05498	COG0235	Class ii aldolase
CO731_05500	COG0444	Belongs to the ABC transporter superfamily
CO731_05501	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_05502	COG0601	transmembrane transport
CO731_05503	COG0747	negative chemotaxis
CO731_05506	COG1473	amidohydrolase
CO731_05507	COG1473	amidohydrolase
CO731_05509	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CO731_05510	COG2894	cell division
CO731_05511	COG0850	regulation of cytokinetic process
CO731_05512	COG2826	transposase and inactivated derivatives, IS30 family
CO731_05516	COG0583	DNA-binding transcription factor activity
CO731_05518	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_05520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CO731_05522	COG0154	amidase activity
CO731_05524	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO731_05536	COG1271	oxidase subunit
CO731_05537	COG1294	oxidase, subunit
CO731_05540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO731_05542	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CO731_05548	COG3483	tryptophan 2,3-dioxygenase activity
CO731_05550	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO731_05552	COG0411	ABC transporter
CO731_05555	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO731_05558	COG1802	Transcriptional regulator
CO731_05559	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO731_05562	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_05563	COG1024	Enoyl-CoA hydratase
CO731_05564	COG1960	acyl-CoA dehydrogenase activity
CO731_05567	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_05567	COG1024	Enoyl-CoA hydratase
CO731_05569	COG0165	Argininosuccinate lyase
CO731_05570	COG0395	ABC-type sugar transport system, permease component
CO731_05572	COG2182	Extracellular solute-binding protein
CO731_05573	COG1940	carbohydrate kinase activity
CO731_05576	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO731_05577	COG4521	taurine ABC transporter
CO731_05578	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CO731_05579	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_05582	COG0028	Belongs to the TPP enzyme family
CO731_05583	COG2855	membrane
CO731_05586	COG2814	Major facilitator Superfamily
CO731_05589	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO731_05590	COG0583	DNA-binding transcription factor activity
CO731_05591	COG0626	cystathionine gamma-synthase activity
CO731_05594	COG0765	amino acid transport
CO731_05595	COG1959	2 iron, 2 sulfur cluster binding
CO731_05599	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CO731_05602	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_05607	COG0179	Fumarylacetoacetate (FAA) hydrolase
CO731_05617	COG4974	Belongs to the 'phage' integrase family
CO731_05618	COG0582	viral genome integration into host DNA
CO731_05619	COG4974	Belongs to the 'phage' integrase family
CO731_05620	COG3547	Transposase (IS116 IS110 IS902 family)
CO731_05622A	COG0582	viral genome integration into host DNA
CO731_05632	COG3504	Conjugal transfer protein
CO731_05633	COG3701	Conjugal transfer protein
CO731_05634	COG3846	protein secretion by the type IV secretion system
CO731_05636	COG5314	conjugation
CO731_05637	COG3451	type IV secretory pathway VirB4
CO731_05639	COG3838	Conjugal transfer protein Trbc
CO731_05640	COG4962	Type ii secretion system protein e
CO731_05641	COG1192	Involved in chromosome partitioning
CO731_05642	COG1475	DNA binding
CO731_05643	COG0640	Transcriptional regulator
CO731_05644	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO731_05645	COG3657	addiction module killer protein
CO731_05646	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CO731_05649	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO731_05671	COG3077	Addiction module antitoxin, RelB DinJ family
CO731_05672	COG3041	Addiction module toxin RelE StbE family
CO731_05677	COG4962	Type ii secretion system protein e
CO731_05678	COG3838	Conjugal transfer protein Trbc
CO731_05679	COG5268	conjugation
CO731_05680	COG3451	type IV secretory pathway VirB4
CO731_05684	COG0318	PFAM AMP-dependent synthetase and ligase