locus-tag	class	description
Amico_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Amico_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Amico_0003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Amico_0008	ENOG4108JYZ	YitT family
Amico_0009	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Amico_0010	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Amico_0011	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Amico_0012	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Amico_0013	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
Amico_0014	ENOG4105CFH	Aspartokinase
Amico_0017	ENOG4105D1F	ATP-binding protein
Amico_0020	ENOG4105I3K	Ferric uptake regulator, Fur family
Amico_0023	ENOG4105DYB	Isoaspartyl dipeptidase
Amico_0027	ENOG4105EIE	fructose-bisphosphate aldolase
Amico_0028	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Amico_0032	ENOG4108HQS	Glycine betaine
Amico_0037	ENOG4105ECY	inositol monophosphatase
Amico_0041	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Amico_0042	ENOG4105E2Z	phosphate ABC transporter (Permease
Amico_0043	ENOG4105C8U	phosphate abc transporter
Amico_0046	ENOG4105E5Q	amino acid AbC transporter
Amico_0047	ENOG4105CDA	abc transporter atp-binding protein
Amico_0051	ENOG41060I7	thioesterase Superfamily protein
Amico_0054	ENOG4105EHG	Permease protein
Amico_0055	ENOG4105D5T	phosphonate abc transporter
Amico_0058	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Amico_0063	ENOG4108JJB	ABC transporter
Amico_0065	ENOG4108A51	
Amico_0066	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
Amico_0068	ENOG4105JAB	phenazine biosynthesis protein, phzf family
Amico_0069	ENOG4105E5Q	amino acid AbC transporter
Amico_0070	ENOG4105CDA	abc transporter atp-binding protein
Amico_0071	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Amico_0073	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Amico_0074	ENOG4105HEE	Binding Domain protein
Amico_0078	ENOG4105EJQ	L-serine dehydratase
Amico_0080	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Amico_0081	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Amico_0082	ENOG4108U5N	UPF0316 protein
Amico_0083	ENOG4105RG0	Membrane
Amico_0084	ENOG4108IA2	Sodium pantothenate symporter
Amico_0085	ENOG4107HP6	Transcriptional regulator
Amico_0086	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Amico_0087	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
Amico_0088	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_0090	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_0093	ENOG4105DZ0	fad dependent oxidoreductase
Amico_0094	ENOG4108RCM	Nitroreductase
Amico_0095	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Amico_0096	ENOG4105C6T	cysteine synthase
Amico_0098	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Amico_0099	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Amico_0100	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Amico_0101	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Amico_0103	ENOG4105DR4	Methyltransferase
Amico_0105	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Amico_0106	ENOG4105D6A	Electron transport complex
Amico_0107	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
Amico_0108	ENOG4105DZB	Electron transport complex
Amico_0109	ENOG4105DGN	Electron transport complex
Amico_0110	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
Amico_0113	ENOG4105CJ2	(LipO)protein
Amico_0114	ENOG4105BZG	amino acid carrier protein
Amico_0115	ENOG4105DJZ	UPF0182 protein
Amico_0116	ENOG4108R96	Methyltransferase, YaeB family
Amico_0117	ENOG4105KME	endoribonuclease L-psp
Amico_0118	ENOG4105CEM	UPF0597 protein
Amico_0119	ENOG4105C87	Aminotransferase class I and II
Amico_0120	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Amico_0122	ENOG41062VX	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Amico_0123	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Amico_0127	ENOG4105DTT	CRISPR-associated helicase, cas3
Amico_0128	ENOG4108XKQ	CRISPR-associated protein, Cas6-related
Amico_0130	ENOG41073TP	transcriptional regulator
Amico_0131	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_0133	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_0135	ENOG4107GFK	fumarate
Amico_0136	ENOG4105C9Q	fumarate hydratase class II
Amico_0137	ENOG4105C6K	Malic enzyme
Amico_0140	ENOG4105D78	K07001 NTE family protein
Amico_0142	ENOG4105CHM	Aminotransferase
Amico_0143	ENOG4105JN3	extra-cytoplasmic solute receptor family protein
Amico_0146	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
Amico_0147	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Amico_0150	ENOG4105VFE	sira family
Amico_0152	ENOG4105EGS	Mechanosensitive ion channel
Amico_0156	ENOG4105C32	Amino acid ABC transporter (Permease)
Amico_0157	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Amico_0158	ENOG4105C0Z	ABC transporter
Amico_0159	ENOG4108IV0	ABC, transporter
Amico_0164	ENOG4107RIU	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity)
Amico_0166	ENOG4108R3E	Dna-3-methyladenine glycosylase i
Amico_0167	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Amico_0170	ENOG4108JQB	penicillin-binding protein 1C
Amico_0172	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Amico_0173	ENOG4105DZW	Dipeptidase
Amico_0174	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
Amico_0175	ENOG4108MRH	transcriptional regulatory protein
Amico_0180	ENOG4105DZW	Dipeptidase
Amico_0183	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Amico_0185	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
Amico_0187	ENOG4105CPF	Cell wall formation (By similarity)
Amico_0190	ENOG41074CX	linocin_m18 bacteriocin protein
Amico_0194	ENOG4105DPN	Oligoendopeptidase f
Amico_0196	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Amico_0197	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Amico_0199	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_0201	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_0206	ENOG4107VHA	regulatoR
Amico_0210	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_0212	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Amico_0216	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Amico_0220	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
Amico_0224	ENOG4108WZ2	response regulator
Amico_0225	ENOG4105QUH	Domain of unknown function (DUF2088)
Amico_0226	ENOG4106PMH	Extracellular solute-binding protein family 3
Amico_0227	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Amico_0228	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Amico_0229	ENOG4107S6Z	Na H antiporter
Amico_0230	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Amico_0232	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Amico_0234	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
Amico_0235	ENOG4107R91	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Amico_0237	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Amico_0238	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Amico_0240	ENOG4108UQV	Membrane
Amico_0242	ENOG4105UIB	(ABC) transporter
Amico_0243	ENOG4108JQ9	ABC transporter
Amico_0245	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Amico_0248	ENOG41088YS	Glycosyl transferase (Group 1
Amico_0249	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
Amico_0252	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Amico_0253	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
Amico_0254	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Amico_0255	ENOG4105DWF	phosphomethylpyrimidine kinase
Amico_0256	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
Amico_0257	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Amico_0259	ENOG4107Z6I	Thiamine biosynthesis protein
Amico_0260	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
Amico_0261	ENOG4108ETV	ABC transporter
Amico_0262	ENOG4105N67	Proton-coupled thiamine transporter YuaJ
Amico_0264	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
Amico_0266	ENOG4108ZVT	methylmalonyl-coA epimerase
Amico_0267	ENOG4105D8K	carboxyl transferase
Amico_0269	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
Amico_0270	ENOG4105D9Q	decarboxylase (Beta subunit)
Amico_0272	ENOG4105PW4	Sugar fermentation stimulation protein homolog
Amico_0276	ENOG4107R4J	Chloride channel
Amico_0277	ENOG4105CK2	sodium dicarboxylate symporter
Amico_0278	ENOG4107UFZ	Cyclic nucleotide-binding protein
Amico_0279	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
Amico_0280	ENOG4105D49	3-dehydroquinate synthase
Amico_0281	ENOG4105EAM	Na Pi-cotransporter
Amico_0282	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Amico_0283	ENOG4105K8Z	Phage shock protein
Amico_0287	ENOG4105D6E	homoserine dehydrogenase
Amico_0289	ENOG4105DB7	PHP domain protein
Amico_0290	ENOG4105C5W	Aldolase
Amico_0291	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Amico_0292	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Amico_0294	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Amico_0295	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Amico_0296	ENOG4107EJC	Preprotein translocase subunit SecG
Amico_0298	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Amico_0299	ENOG4108UJD	30S ribosomal protein S9
Amico_0300	ENOG4105CJW	magnesium transporter
Amico_0301	ENOG4108IG5	Transcriptional regulator
Amico_0308	ENOG4105WH1	Two component transcriptional regulator luxr family
Amico_0311	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Amico_0312	ENOG4105WDJ	50S ribosomal protein L33
Amico_0314	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Amico_0315	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Amico_0316	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Amico_0317	ENOG4108VZM	50s ribosomal protein L10
Amico_0318	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Amico_0319	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Amico_0327	ENOG4105FR1	rard protein
Amico_0331	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Amico_0333	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Amico_0335	ENOG4105EHG	Permease protein
Amico_0336	ENOG4105E0A	ABC, transporter
Amico_0340	ENOG4105C8J	)-transporter
Amico_0341	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Amico_0344	ENOG4105CHC	glucokinase (EC 2.7.1.2)
Amico_0347	ENOG4105C5H	ABC transporter
Amico_0348	ENOG4105DJB	Major Facilitator Superfamily
Amico_0350	ENOG4105C1J	atp-dependent rna helicase
Amico_0351	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
Amico_0354	ENOG4108PCN	EamA-like transporter family
Amico_0355	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
Amico_0357	ENOG4105K95	(LipO)protein
Amico_0358	ENOG4105C2J	ABC transporter
Amico_0362	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
Amico_0363	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Amico_0364	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Amico_0366	ENOG4105E4C	Lytic transglycosylase catalytic
Amico_0367	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Amico_0368	ENOG4105CHM	Aminotransferase
Amico_0369	ENOG4105E3H	phosphoglycerate mutase
Amico_0371	ENOG4105EI2	Pseudouridine synthase
Amico_0374	ENOG4105D82	Glutamate dehydrogenase
Amico_0375	ENOG4105C5S	asparaginyl-tRNA synthetase
Amico_0376	ENOG4105CEY	Amp-dependent synthetase and ligase
Amico_0377	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Amico_0380	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Amico_0382	ENOG4108WYP	Transcriptional regulator
Amico_0386	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Amico_0390	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Amico_0391	ENOG4108ZAI	phosphatidylglycerophosphatase a
Amico_0392	ENOG4105CEV	competence damage-inducible protein
Amico_0393	ENOG4105M7V	2'-5' rna ligase
Amico_0394	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Amico_0395	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Amico_0397	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
Amico_0399	ENOG4105MAX	Superoxide reductase
Amico_0402	ENOG4105CNW	domain protein
Amico_0405	ENOG4105DEU	major facilitator superfamily
Amico_0410	ENOG4105CY0	Metallo-Beta-Lactamase
Amico_0412	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Amico_0413	ENOG4105D1S	lipid A biosynthesis
Amico_0415	ENOG4105EAD	ABC transporter
Amico_0418	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Amico_0422	ENOG4105C6F	GntR Family Transcriptional Regulator
Amico_0423	ENOG4105C22	threonyL-tRNA synthetase
Amico_0427	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Amico_0429	ENOG4105C3G	gtp-binding protein
Amico_0434	ENOG4105TMB	Formate nitrite transporter
Amico_0438	ENOG4108WBT	adenosyltransferase
Amico_0439	ENOG4105J4Q	Transcriptional regulator
Amico_0441	ENOG4105JSC	dimethylmenaquinone methyltransferase
Amico_0447	ENOG4105CHY	citrate lyase, alpha
Amico_0449	ENOG4105CVR	type I restriction-modification system
Amico_0450	ENOG41082EK	Restriction modification system DNA (Specificity
Amico_0451	ENOG4105DZR	Type I site-specific deoxyribonuclease
Amico_0454	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Amico_0456	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Amico_0457	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
Amico_0459	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_0461	ENOG4105C28	cystathionine
Amico_0462	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
Amico_0463	ENOG410841Q	phosphoesterase PA-phosphatase related protein
Amico_0465	ENOG4105C3U	ABC transporter
Amico_0467	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Amico_0468	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
Amico_0472	ENOG4105E0X	reductase
Amico_0477	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Amico_0478	ENOG4105D64	Mechanosensitive ion channel
Amico_0488	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Amico_0489	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Amico_0491	ENOG4105D6E	homoserine dehydrogenase
Amico_0494	ENOG4105VEQ	Cold shock protein
Amico_0496	ENOG4105P4J	Allophanate hydrolase, subunit 1
Amico_0498	ENOG4105E7W	lamb ycsf family protein
Amico_0499	ENOG4105CFM	UPF0317 protein
Amico_0500	ENOG4105CR5	Class II aldolase adducin family protein
Amico_0511	ENOG4108WYP	Transcriptional regulator
Amico_0515	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Amico_0516	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Amico_0518	ENOG4105CHM	Aminotransferase
Amico_0519	ENOG4105D6E	homoserine dehydrogenase
Amico_0524	ENOG4105HMI	Membrane
Amico_0525	ENOG4105DUM	transcriptional regulator, lysR family
Amico_0526	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Amico_0528	ENOG4105DZS	Phenylacetate-CoA ligase
Amico_0530	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Amico_0532	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Amico_0534	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Amico_0535	ENOG4105BZM	domain protein
Amico_0537	ENOG4105MCT	stage V sporulation protein S
Amico_0538	ENOG4105CUT	histidyl-tRNA synthetase
Amico_0539	ENOG4105C9M	aspartyl-trna synthetase
Amico_0540	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Amico_0544	ENOG4105EF7	Transcriptional regulator
Amico_0545	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Amico_0550	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
Amico_0552	ENOG4105K5M	30s ribosomal protein S16
Amico_0553	ENOG4105VB6	UPF0109 protein
Amico_0554	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Amico_0555	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Amico_0556	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Amico_0558	ENOG4105E3H	phosphoglycerate mutase
Amico_0560	ENOG4105CD5	CoA-binding domain protein
Amico_0561	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Amico_0562	ENOG4105KEX	transcriptional regulator, ctsr
Amico_0568	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Amico_0570	ENOG4105C8J	)-transporter
Amico_0572	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Amico_0573	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Amico_0576	ENOG4108IUZ	ABC transporter
Amico_0580	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Amico_0581	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Amico_0582	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Amico_0583	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Amico_0584	ENOG4105F4G	Membrane
Amico_0586	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Amico_0587	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Amico_0588	ENOG41082I2	s4 domain protein
Amico_0589	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Amico_0590	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
Amico_0592	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Amico_0593	ENOG4108JIS	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Amico_0594	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
Amico_0596	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Amico_0598	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Amico_0599	ENOG4105C5X	domain protein
Amico_0600	ENOG4105W5Q	DNA repair protein (RadC
Amico_0601	ENOG4105DFF	Rod shape-determining protein mreb
Amico_0604	ENOG4105CJN	penicillin-binding protein
Amico_0605	ENOG4107XW6	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Amico_0607	ENOG41083CN	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Amico_0608	ENOG4105CNI	cell division protein FtsW
Amico_0611	ENOG4105C03	ribonuclease
Amico_0613	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
Amico_0614	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Amico_0615	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Amico_0616	ENOG4105F8V	Hydrolase, tatD family
Amico_0617	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Amico_0618	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Amico_0619	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Amico_0620	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Amico_0622	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Amico_0623	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Amico_0624	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Amico_0625	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Amico_0626	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Amico_0627	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Amico_0628	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Amico_0629	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Amico_0630	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Amico_0631	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Amico_0632	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Amico_0633	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Amico_0634	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Amico_0635	ENOG41082SA	50s ribosomal protein l29
Amico_0636	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Amico_0637	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Amico_0638	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Amico_0639	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Amico_0640	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Amico_0641	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Amico_0642	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Amico_0643	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Amico_0644	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Amico_0645	ENOG41084HK	50S ribosomal protein L30
Amico_0647	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Amico_0649	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Amico_0651	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Amico_0652	ENOG41067V7	50S ribosomal protein L36
Amico_0653	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Amico_0654	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Amico_0655	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Amico_0656	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Amico_0657	ENOG4108ZT0	50S ribosomal protein l17
Amico_0658	ENOG4108JJB	ABC transporter
Amico_0660	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Amico_0661	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Amico_0662	ENOG4105DFF	Rod shape-determining protein mreb
Amico_0677	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Amico_0678	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Amico_0679	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Amico_0681	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Amico_0682	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Amico_0683	ENOG4105CUT	histidyl-tRNA synthetase
Amico_0684	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Amico_0685	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Amico_0687	ENOG4107QX8	SPFH domain, Band 7 family protein
Amico_0688	ENOG4105C8T	Leucyl-tRNA synthetase
Amico_0690	ENOG410857I	Binds directly to 16S ribosomal RNA (By similarity)
Amico_0691	ENOG4105DVT	helicase
Amico_0693	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Amico_0694	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Amico_0695	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
Amico_0697	ENOG4105C0H	protease
Amico_0699	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Amico_0700	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Amico_0701	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Amico_0702	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Amico_0703	ENOG4105C22	threonyL-tRNA synthetase
Amico_0704	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Amico_0706	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Amico_0709	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Amico_0710	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Amico_0714	ENOG4105C98	muts2 protein
Amico_0715	ENOG4105CCS	Glutamate formiminotransferase
Amico_0716	ENOG4107HP6	Transcriptional regulator
Amico_0723	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Amico_0724	ENOG4105CBJ	Metal-dependent enzyme
Amico_0725	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Amico_0726	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Amico_0727	ENOG4105C3M	thioredoxin reductase
Amico_0731	ENOG4105C6E	dna polymerase iii
Amico_0732	ENOG4105C0B	DNA polymerase III (alpha subunit)
Amico_0735	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Amico_0736	ENOG4106M28	alanine racemase domain protein
Amico_0739	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Amico_0740	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Amico_0741	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Amico_0743	ENOG4105CPN	adenine deaminase
Amico_0745	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Amico_0747	ENOG4108227	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Amico_0748	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Amico_0749	ENOG4108JA2	transcriptioN-repair coupling factor
Amico_0750	ENOG4105DXN	mazG family
Amico_0751	ENOG4107QSA	Oxaloacetate decarboxylase
Amico_0752	ENOG4105C9A	Phoh family
Amico_0753	ENOG4105CTJ	Metal Dependent Phosphohydrolase
Amico_0754	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Amico_0755	ENOG4108JU6	CBS domain protein
Amico_0756	ENOG4105KG3	cytidine deaminase
Amico_0757	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Amico_0759	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
Amico_0760	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Amico_0762	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Amico_0763	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Amico_0765	ENOG4108JQC	penicillin-binding protein 1A
Amico_0766	ENOG4107QHF	type ii secretion system protein e
Amico_0778	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Amico_0779	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Amico_0780	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Amico_0782	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Amico_0784	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Amico_0785	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Amico_0786	ENOG4105C3U	ABC transporter
Amico_0787	ENOG4108JQ7	(ABC) transporter
Amico_0790	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Amico_0791	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Amico_0792	ENOG4105K8N	protein family UPF0079, ATPase
Amico_0793	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Amico_0795	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Amico_0796	ENOG4105DQU	oxidoreductase, subunit beta
Amico_0800	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Amico_0804	ENOG41083MH	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Amico_0807	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Amico_0809	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Amico_0810	ENOG4108V6E	Cell division protein mraZ
Amico_0811	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Amico_0813	ENOG4105CJN	penicillin-binding protein
Amico_0814	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Amico_0815	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
Amico_0816	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Amico_0817	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Amico_0819	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Amico_0820	ENOG4105DFU	Cell wall formation (By similarity)
Amico_0821	ENOG4105D4A	Cell wall formation (By similarity)
Amico_0823	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Amico_0824	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Amico_0828	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Amico_0829	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Amico_0830	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Amico_0831	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Amico_0833	ENOG4105CIE	May be required for sporulation (By similarity)
Amico_0835	ENOG4105BZA	Phosphoglycerate kinase
Amico_0836	ENOG4105CP7	Triose-phosphate isomerase
Amico_0842	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Amico_0843	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Amico_0844	ENOG4105K46	50S ribosomal protein l27
Amico_0846	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Amico_0847	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Amico_0848	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Amico_0849	ENOG4105DX0	Hemolysin A
Amico_0850	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Amico_0852	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Amico_0853	ENOG4105VB9	50S ribosomal protein l28
Amico_0855	ENOG4105CNU	cell division protein FtsK
Amico_0856	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Amico_0858	ENOG4105HHA	aminodeoxychorismate lyase
Amico_0860	ENOG4105NBF	ammecr1 domain protein
Amico_0861	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Amico_0862	ENOG4105JFG	SpoIID LytB domain protein
Amico_0863	ENOG41061AI	Protein of unknown function (DUF2905)
Amico_0864	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Amico_0865	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Amico_0866	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Amico_0867	ENOG4105CDY	transcriptional regulatory protein
Amico_0868	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
Amico_0869	ENOG4105MRR	Transcriptional regulator (By similarity)
Amico_0870	ENOG4105DBV	ornithine carbamoyltransferase
Amico_0871	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Amico_0872	ENOG4105DZP	Membrane-associated zinc metalloprotease
Amico_0873	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Amico_0875	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Amico_0876	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Amico_0879	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Amico_0880	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Amico_0881	ENOG4107UKG	Glycosyl transferase, family 4
Amico_0882	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Amico_0883	ENOG4105D9Q	decarboxylase (Beta subunit)
Amico_0886	ENOG4105D8K	carboxyl transferase
Amico_0888	ENOG4105D5P	Methylmalonyl-coA mutase
Amico_0893	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Amico_0894	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Amico_0895	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Amico_0896	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Amico_0897	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Amico_0898	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Amico_0899	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Amico_0900	ENOG4105VEQ	Cold shock protein
Amico_0902	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Amico_0905	ENOG4108V0P	LemA family
Amico_0908	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Amico_0909	ENOG4107RCV	ABC transporter, permease
Amico_0910	ENOG4105C4Y	ABC transporter
Amico_0913	ENOG4105EJQ	L-serine dehydratase
Amico_0917	ENOG4105CEM	UPF0597 protein
Amico_0918	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_0929	ENOG41087WU	
Amico_0941	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Amico_0942	ENOG4105DIN	metallophosphoesterase
Amico_0949	ENOG4105CDU	Replicative dna helicase
Amico_0956	ENOG4105DTQ	mandelate racemase muconate lactonizing
Amico_0959	ENOG4105F23	Fibronectin-binding protein
Amico_0960	ENOG4105C34	Pseudouridine synthase
Amico_0961	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Amico_0964	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Amico_0966	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Amico_0967	ENOG4105DTN	riboflavin biosynthesis protein ribF
Amico_0968	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Amico_0969	ENOG4105SFS	phosphoesterase RecJ domain protein
Amico_0970	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Amico_0972	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Amico_0974	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
Amico_0975	ENOG4105CHV	Transcription elongation factor NusA
Amico_0976	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Amico_0977	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Amico_0978	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Amico_0979	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Amico_0980	ENOG4105CTP	PilT protein domain protein
Amico_0981	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Amico_0982	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Amico_0983	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Amico_0984	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Amico_0985	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Amico_0986	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Amico_0991	ENOG4105EBX	v-type atpase
Amico_0995	ENOG4105CH2	amidohydrolase
Amico_0996	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Amico_0998	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Amico_0999	ENOG4108R6K	riboflavin synthase, subunit alpha
Amico_1000	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Amico_1001	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Amico_1002	ENOG4105C8N	cysteinyl-tRNA synthetase
Amico_1005	ENOG41088CC	tellurite resistance protein tehB
Amico_1008	ENOG4108RAC	Rubrerythrin
Amico_1011	ENOG4105DR5	peptidase
Amico_1013	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
Amico_1014	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Amico_1015	ENOG4108YZ4	nudix hydrolase
Amico_1018	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Amico_1021	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Amico_1023	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Amico_1024	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Amico_1025	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Amico_1026	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Amico_1027	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Amico_1028	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Amico_1029	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Amico_1030	ENOG41080U2	Amidohydrolase family
Amico_1031	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Amico_1032	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Amico_1033	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Amico_1034	ENOG4105M7K	Involved in the transcription termination process (By similarity)
Amico_1038	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Amico_1039	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Amico_1040	ENOG4105KGF	protein, YerC YecD
Amico_1042	ENOG4105DAN	ATP-dependent protease
Amico_1043	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Amico_1048	ENOG4105C83	adenylosuccinate lyase
Amico_1050	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Amico_1051	ENOG4105MA4	psp1 domain protein
Amico_1052	ENOG4107QRG	dna polymerase iii
Amico_1053	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Amico_1054	ENOG4105S1Z	Stage IV sporulation protein B
Amico_1056	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
Amico_1057	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Amico_1059	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Amico_1060	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Amico_1061	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Amico_1062	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Amico_1063	ENOG4105CHR	reductase
Amico_1064	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Amico_1065	ENOG4105EA8	2-Nitropropane dioxygenase
Amico_1066	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Amico_1067	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Amico_1068	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
Amico_1069	ENOG41067VY	50S ribosomal protein L32
Amico_1071	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Amico_1072	ENOG4105CDE	UPF0348 protein
Amico_1073	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Amico_1074	ENOG4106H78	methyltransferase
Amico_1076	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Amico_1077	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Amico_1078	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Amico_1079	ENOG4105K70	DNA-binding protein
Amico_1080	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Amico_1081	ENOG4105C25	Primosomal protein n'
Amico_1082	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Amico_1084	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Amico_1085	ENOG4105KC4	UPF0296 protein
Amico_1086	ENOG4105DSJ	YicC domain protein
Amico_1087	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Amico_1088	ENOG4105CEY	Amp-dependent synthetase and ligase
Amico_1089	ENOG4107RB4	Cytidine monophosphate kinase
Amico_1091	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Amico_1092	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Amico_1093	ENOG4105C31	Tryptophanyl-tRNA synthetase
Amico_1094	ENOG4105EGD	dinuclear metal center protein, YbgI family
Amico_1131	ENOG4105F5W	AtP-binding protein
Amico_1133	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Amico_1142	ENOG4108IMY	Transcriptional regulator
Amico_1147	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Amico_1151	ENOG4105DFP	Integrase
Amico_1152	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
Amico_1153	ENOG4105DFT	pur operon repressor
Amico_1154	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Amico_1156	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Amico_1157	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
Amico_1161	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Amico_1162	ENOG4105C8V	SAICAR synthetase
Amico_1164	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Amico_1167	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Amico_1168	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Amico_1169	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Amico_1170	ENOG4107QNG	Phosphoribosylglycinamide synthetase
Amico_1171	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Amico_1174	ENOG4105CDH	Citrulline--aspartate ligase
Amico_1175	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Amico_1176	ENOG4108Z4T	Peptidase M50
Amico_1178	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Amico_1179	ENOG4105C4R	Atp-dependent dna helicase
Amico_1180	ENOG4107RSS	Hydrogenase accessory protein HypB
Amico_1182	ENOG4105MS2	ribosomal subunit Interface protein
Amico_1184	ENOG4105C5I	Dehydrogenase
Amico_1185	ENOG4105C7N	Xanthine uracil vitamin C permease
Amico_1186	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Amico_1187	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Amico_1188	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Amico_1189	ENOG4105CE9	30S ribosomal protein S2
Amico_1190	ENOG4105VPX	protein, conserved in bacteria
Amico_1191	ENOG4108V1U	phospholipid-binding protein
Amico_1193	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
Amico_1194	ENOG4105CJW	magnesium transporter
Amico_1200	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Amico_1201	ENOG4105GVR	general secretion pathway protein D
Amico_1205	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
Amico_1208	ENOG4105WH1	Two component transcriptional regulator luxr family
Amico_1209	ENOG4105BZU	Histidine kinase
Amico_1210	ENOG4105CHU	acetyl-coa acetyltransferase
Amico_1211	ENOG4107QNJ	CoA-transferase subunit B
Amico_1212	ENOG4107QP7	CoA-transferase subunit A
Amico_1215	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Amico_1217	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
Amico_1221	ENOG4105BZU	Histidine kinase
Amico_1224	ENOG4105CEU	Arginine dihydrolase
Amico_1226	ENOG4105DAA	L-lactate
Amico_1227	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Amico_1228	ENOG4108K88	Membrane
Amico_1229	ENOG4108RAC	Rubrerythrin
Amico_1230	ENOG4108Z6B	deaminase
Amico_1234	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
Amico_1238	ENOG4105DFM	M18 family aminopeptidase
Amico_1239	ENOG4105D1Z	hydroxypyruvate reductase
Amico_1248	ENOG4105CE1	Ferrous iron transport protein b
Amico_1249	ENOG4108RWI	nicotinamidase
Amico_1250	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Amico_1251	ENOG4108HW3	(ABC) transporter
Amico_1257	ENOG4105M6F	mutator MutT protein
Amico_1259	ENOG4105C2M	dna polymerase I
Amico_1261	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Amico_1262	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Amico_1263	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Amico_1264	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Amico_1265	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Amico_1266	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
Amico_1268	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Amico_1271	ENOG4105D65	subunit l
Amico_1273	ENOG4105KJM	monovalent cation h antiporter subunit g
Amico_1275	ENOG4105SC1	monovalent cation H antiporter subunit E
Amico_1280	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Amico_1281	ENOG4105D7N	magnesium and cobalt transport protein CorA
Amico_1287	ENOG4105C1A	potassium transporter peripheral membrane
Amico_1288	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Amico_1294	ENOG41067MG	lrgb family
Amico_1295	ENOG4105VAW	lrga family
Amico_1296	ENOG4105KME	endoribonuclease L-psp
Amico_1300	ENOG4105ERH	Fumarylacetoacetate hydrolase
Amico_1301	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Amico_1302	ENOG4105DRR	Transcriptional regulator, GntR family
Amico_1303	ENOG4105C0A	alcohol dehydrogenase
Amico_1304	ENOG4105QUH	Domain of unknown function (DUF2088)
Amico_1305	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1306	ENOG4108K1J	Transporter DctQ
Amico_1307	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_1308	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Amico_1310	ENOG4105JXH	GntR family transcriptional regulator
Amico_1313	ENOG4105EJ5	oxidoreductase gamma subunit
Amico_1314	ENOG4105WGB	oxidoreductase, delta subunit
Amico_1315	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Amico_1316	ENOG4105DDK	oxidoreductase, beta subunit
Amico_1319	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1321	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_1324	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
Amico_1325	ENOG4105DG4	malate L-lactate dehydrogenase
Amico_1332	ENOG4105CNW	domain protein
Amico_1333	ENOG4105K78	MarR family Transcriptional regulator
Amico_1334	ENOG41084S7	Plasmid maintenance system antidote protein
Amico_1337	ENOG4105C0D	helicase
Amico_1339	ENOG4108UQS	dipeptidase
Amico_1340	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1342	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_1346	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
Amico_1349	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Amico_1350	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Amico_1352	ENOG4105CHJ	isochorismatase hydrolase
Amico_1357	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Amico_1359	ENOG4108DMA	Nad-dependent epimerase dehydratase
Amico_1361	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Amico_1362	ENOG4105WH1	Two component transcriptional regulator luxr family
Amico_1363	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Amico_1364	ENOG4105DIW	FeS assembly protein SUFB
Amico_1365	ENOG4105C3K	feS assembly ATPase SufC
Amico_1366	ENOG4107QYV	phosphohexose isomerase
Amico_1368	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
Amico_1371	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Amico_1372	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Amico_1373	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Amico_1374	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Amico_1375	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Amico_1376	ENOG4105CRK	lysyL-tRNA synthetase
Amico_1378	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Amico_1379	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Amico_1383	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
Amico_1384	ENOG4105VCQ	rubredoxin
Amico_1385	ENOG4105DC7	peptidase M24
Amico_1386	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
Amico_1388	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Amico_1389	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Amico_1390	ENOG4105BZG	amino acid carrier protein
Amico_1394	ENOG4105CYT	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Amico_1395	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
Amico_1396	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
Amico_1397	ENOG4105EZ5	reductase
Amico_1400	ENOG4105C8J	)-transporter
Amico_1402	ENOG4105CQS	hydrogenase expression formation protein HypD
Amico_1403	ENOG4105C45	hydrogenase expression formation protein (HypE)
Amico_1404	ENOG4105D48	metallophosphoesterase
Amico_1405	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Amico_1406	ENOG4105Y3E	Modulates RecA activity (By similarity)
Amico_1410	ENOG4105DFA	alanine racemase domain protein
Amico_1412	ENOG4105C5I	Dehydrogenase
Amico_1413	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
Amico_1414	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
Amico_1417	ENOG4105CDU	Replicative dna helicase
Amico_1418	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Amico_1420	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Amico_1421	ENOG4108UUM	single-stranded DNA-binding protein
Amico_1422	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Amico_1424	ENOG4105C75	arginyL-tRNA synthetase
Amico_1426	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Amico_1427	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Amico_1428	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Amico_1429	ENOG4108IV0	ABC, transporter
Amico_1430	ENOG4105C0Z	ABC transporter
Amico_1431	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Amico_1432	ENOG4105C32	Amino acid ABC transporter (Permease)
Amico_1434	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Amico_1437	ENOG4107YU2	histidine triad (hIT) protein
Amico_1438	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Amico_1440	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Amico_1442	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Amico_1443	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Amico_1445	ENOG4105EEI	dihydropteroate synthase
Amico_1446	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Amico_1449	ENOG4105DQU	oxidoreductase, subunit beta
Amico_1452	ENOG4105D22	carbon starvation protein
Amico_1454	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Amico_1455	ENOG4105PXI	polysaccharide deacetylase
Amico_1456	ENOG4105CN1	protease
Amico_1457	ENOG4105DR5	peptidase
Amico_1458	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Amico_1459	ENOG4105CAK	Cell division ATP-binding protein ftsE
Amico_1461	ENOG4108HHA	Transketolase
Amico_1464	ENOG4108Z03	MAF-like protein
Amico_1466	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Amico_1467	ENOG4105CN5	Metallo-Beta-Lactamase
Amico_1468	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Amico_1469	ENOG4105CPF	Cell wall formation (By similarity)
Amico_1474	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Amico_1476	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Amico_1477	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Amico_1481	ENOG4105CTQ	phosphohexokinase
Amico_1484	ENOG4105ZU5	s-layer protein
Amico_1486	ENOG4105DKP	glycosyl transferase, family 9
Amico_1487	ENOG4105CPK	Glycosyl transferase (Group 1
Amico_1488	ENOG4107TYR	Glycosyl Transferase
Amico_1490	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Amico_1492	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Amico_1493	ENOG4105C2X	Arabinose 5-phosphate isomerase
Amico_1494	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Amico_1495	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Amico_1496	ENOG4105BZ1	(ABC) transporter
Amico_1498	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Amico_1499	ENOG4105GYT	Protein of unknown function (DUF1009)
Amico_1501	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
Amico_1502	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Amico_1503	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Amico_1504	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Amico_1505	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Amico_1509	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Amico_1510	ENOG4105CVJ	phosphoglycerate mutase
Amico_1512	ENOG4105CH7	arginosuccinase
Amico_1514	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Amico_1515	ENOG4107YTP	response regulator receiver protein
Amico_1517	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Amico_1518	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Amico_1519	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Amico_1521	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Amico_1524	ENOG4105C0P	Mg chelatase subunit ChlI
Amico_1525	ENOG41080R2	UPF0102 protein
Amico_1526	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Amico_1527	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Amico_1534	ENOG4105CJW	magnesium transporter
Amico_1535	ENOG4105CIF	Ornithine Cyclodeaminase
Amico_1537	ENOG4105CKU	formyltetrahydrofolate synthetase
Amico_1538	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
Amico_1539	ENOG4105CCS	Glutamate formiminotransferase
Amico_1540	ENOG4108KJ1	Trap dicarboxylate transporter, dctp subunit
Amico_1541	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1542	ENOG4108K1J	Transporter DctQ
Amico_1543	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Amico_1545	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Amico_1546	ENOG4105CKU	formyltetrahydrofolate synthetase
Amico_1549	ENOG4105D9Q	decarboxylase (Beta subunit)
Amico_1555	ENOG4108JB9	formate dehydrogenase
Amico_1556	ENOG4107QIZ	NADH dehydrogenase
Amico_1560	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
Amico_1561	ENOG4105C8W	ABC transporter
Amico_1565	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Amico_1567	ENOG4108JQ9	ABC transporter
Amico_1568	ENOG4105UIB	(ABC) transporter
Amico_1570	ENOG4107TFB	basic membrane
Amico_1571	ENOG4105CGH	5'-nucleotidase
Amico_1572	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Amico_1576	ENOG4107RCV	ABC transporter, permease
Amico_1577	ENOG4105C4Y	ABC transporter
Amico_1578	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
Amico_1581	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1582	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1583	ENOG4107QN2	dihydrolipoyl dehydrogenase
Amico_1588	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_1590	ENOG4105CPP	Dehydrogenase, E1 component
Amico_1591	ENOG4107RUY	(E1 component), alpha subunit
Amico_1593	ENOG4108UVJ	appr-1-p processing domain protein
Amico_1596	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Amico_1597	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Amico_1598	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Amico_1599	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Amico_1600	ENOG4105CD3	dihydroorotase
Amico_1601	ENOG4105CXT	aspartate transcarbamylase
Amico_1602	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Amico_1603	ENOG4105CHM	Aminotransferase
Amico_1604	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Amico_1605	ENOG4108FUF	Transcriptional regulator, IclR family
Amico_1608	ENOG4108RNG	Permease of the drug metabolite transporter
Amico_1609	ENOG4105C5I	Dehydrogenase
Amico_1611	ENOG4105CEY	Amp-dependent synthetase and ligase
Amico_1614	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
Amico_1620	ENOG4105CI3	gtp-binding protein typa
Amico_1621	ENOG4105BZU	Histidine kinase
Amico_1622	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Amico_1627	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Amico_1628	ENOG4105DZW	Dipeptidase
Amico_1634	ENOG4105DZW	Dipeptidase
Amico_1638	ENOG4105C7Z	Conserved Protein
Amico_1640	ENOG4108UMN	azlc family
Amico_1641	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Amico_1642	ENOG4105D6E	homoserine dehydrogenase
Amico_1644	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Amico_1647	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Amico_1649	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Amico_1652	ENOG4105DRR	Transcriptional regulator, GntR family
Amico_1654	ENOG4105CH2	amidohydrolase
Amico_1656	ENOG4105DEF	Extracellular solute-binding protein, family 5
Amico_1658	ENOG4108JQ7	(ABC) transporter
Amico_1660	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Amico_1661	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Amico_1662	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Amico_1663	ENOG4105DG4	malate L-lactate dehydrogenase
Amico_1664	ENOG4105QUH	Domain of unknown function (DUF2088)
Amico_1665	ENOG4108UHU	Aldolase
Amico_1667	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Amico_1668	ENOG4108UMI	ABC transporter, permease
Amico_1669	ENOG4105D01	(LipO)protein
Amico_1670	ENOG4105CXK	mandelate racemase muconate lactonizing
Amico_1673	ENOG4105J4Q	Transcriptional regulator
Amico_1674	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1676	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
Amico_1677	ENOG4105CTX	dehydratase
Amico_1678	ENOG4105CVA	phosphate
Amico_1679	ENOG4105C8U	phosphate abc transporter
Amico_1680	ENOG4105E2Z	phosphate ABC transporter (Permease
Amico_1681	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Amico_1683	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Amico_1684	ENOG4105BZU	Histidine kinase
Amico_1687	ENOG4105DIN	metallophosphoesterase
Amico_1688	ENOG4107HP6	Transcriptional regulator
Amico_1691	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_1692	ENOG4108JPW	Aminotransferase
Amico_1693	ENOG4105Z5Q	
Amico_1695	ENOG4108VW9	Membrane
Amico_1696	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Amico_1698	ENOG4105G6Z	alkaline phosphatase
Amico_1703	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Amico_1704	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Amico_1716	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Amico_1717	ENOG4105D3Q	Sugar transferase
Amico_1720	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Amico_1723	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Amico_1725	ENOG4105CHR	reductase
Amico_1726	ENOG4107QQG	Dehydrogenase
Amico_1731	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Amico_1734	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
Amico_1749	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1750	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
Amico_1751	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_1752	ENOG4105CHM	Aminotransferase
Amico_1756	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1757	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1759	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1762	ENOG4105NBK	UPF0345 protein
Amico_1764	ENOG4105DSF	transport protein
Amico_1765	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
Amico_1766	ENOG4105K6H	D-cysteine desulfhydrase
Amico_1767	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Amico_1768	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Amico_1774	ENOG4105VEQ	Cold shock protein
Amico_1776	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Amico_1779	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Amico_1780	ENOG4105C3U	ABC transporter
Amico_1783	ENOG4105CVJ	phosphoglycerate mutase
Amico_1784	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
Amico_1785	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Amico_1786	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Amico_1790	ENOG4105C6K	Malic enzyme
Amico_1791	ENOG4105CEY	Amp-dependent synthetase and ligase
Amico_1792	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Amico_1793	ENOG4105C8M	UPF0272 protein
Amico_1795	ENOG4105CH2	amidohydrolase
Amico_1800	ENOG4107QSE	Dipeptidase
Amico_1801	ENOG4105CFG	Acts as a chaperone (By similarity)
Amico_1809	ENOG4107VRP	DNA repair exonuclease
Amico_1813	ENOG4108Z3G	3H domain protein
Amico_1815	ENOG4105BZU	Histidine kinase
Amico_1818	ENOG4105DJ9	glucan biosynthesis protein
Amico_1822	ENOG4105CPI	Metal Dependent Phosphohydrolase
Amico_1823	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Amico_1826	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Amico_1829	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Amico_1830	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1831	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1832	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
Amico_1835	ENOG4107RNN	dihydropyrimidinase (EC 3.5.2.2)
Amico_1836	ENOG4107HP6	Transcriptional regulator
Amico_1837	ENOG4105C5R	Aminotransferase
Amico_1839	ENOG4105CKM	Branched-chain carboxylic acid kinase
Amico_1840	ENOG4107RE7	phosphate butyryltransferase
Amico_1841	ENOG4107RE7	phosphate butyryltransferase
Amico_1842	ENOG4105CKM	Branched-chain carboxylic acid kinase
Amico_1843	ENOG4108ESY	Metal dependent phosphohydrolase
Amico_1848	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Amico_1851	ENOG4105FA0	parb-like partition protein
Amico_1852	ENOG4107QJE	Chromosome Partitioning Protein
Amico_1853	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Amico_1854	ENOG4107Y9E	nuclease
Amico_1860	ENOG4105CH2	amidohydrolase
Amico_1863	ENOG4107XSR	periplasmic solute binding protein
Amico_1871	ENOG4108XG2	Histidine kinase
Amico_1873	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Amico_1876	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Amico_1877	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Amico_1878	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
Amico_1879	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Amico_1881	ENOG4105CHR	reductase
Amico_1882	ENOG4105CPC	Aldo Keto reductase
Amico_1885	ENOG4105CI2	imidazolone-5-propionate hydrolase
Amico_1886	ENOG4105CGP	Urocanate hydratase
Amico_1888	ENOG4105C4Y	ABC transporter
Amico_1889	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
Amico_1891	ENOG4105CIZ	coA-substrate-specific enzyme activase
Amico_1896	ENOG4105C59	p-type ATPase
Amico_1900	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Amico_1901	ENOG4105CH2	amidohydrolase
Amico_1902	ENOG4108U5N	UPF0316 protein
Amico_1903	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
Amico_1905	ENOG4105C84	Histidine ammonia-lyase
Amico_1906	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Amico_1908	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Amico_1909	ENOG4105C9B	Cysteine desulfurase