locus-tag	class	description
Amico_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Amico_0002	COG0592	DNA-directed DNA polymerase activity
Amico_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Amico_0008	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Amico_0010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Amico_0011	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amico_0012	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Amico_0013	COG2171	N-acyltransferase activity
Amico_0017	COG0489	protein tyrosine kinase activity
Amico_0020	COG0735	belongs to the Fur family
Amico_0023	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Amico_0027	COG1830	Aldolase
Amico_0028	COG2084	Dehydrogenase
Amico_0032	COG4176	ABC-type proline glycine betaine transport system permease component
Amico_0037	COG0483	inositol monophosphate 1-phosphatase activity
Amico_0038	COG1283	sodium-dependent phosphate transmembrane transporter activity
Amico_0041	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Amico_0042	COG0581	inorganic phosphate transmembrane transporter activity
Amico_0043	COG0573	inorganic phosphate transmembrane transporter activity
Amico_0047	COG1126	abc transporter atp-binding protein
Amico_0054	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amico_0055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Amico_0058	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Amico_0059	COG2217	Heavy metal translocating P-type atpase
Amico_0063	COG1122	ATPase activity
Amico_0065	COG0310	cobalt ion transport
Amico_0066	COG0310	cobalt ion transport
Amico_0068	COG0384	phenazine biosynthesis protein PhzF
Amico_0070	COG1126	abc transporter atp-binding protein
Amico_0071	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Amico_0073	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amico_0074	COG0348	domain, Protein
Amico_0074	COG3901	Regulator of nitric oxide reductase transcription
Amico_0077	COG1760	l-serine dehydratase
Amico_0078	COG1760	l-serine dehydratase
Amico_0080	COG0442	prolyl-tRNA aminoacylation
Amico_0082	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Amico_0083	COG3924	membrane
Amico_0084	COG4145	pantothenate transmembrane transporter activity
Amico_0085	COG1414	Transcriptional regulator
Amico_0086	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Amico_0087	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Amico_0088	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_0093	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Amico_0094	COG0778	Nitroreductase
Amico_0095	COG0167	dihydroorotate dehydrogenase activity
Amico_0097	COG1045	serine acetyltransferase
Amico_0098	COG0473	3-isopropylmalate dehydrogenase activity
Amico_0099	COG0066	3-isopropylmalate dehydratase activity
Amico_0100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Amico_0101	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Amico_0105	COG4656	Part of a membrane complex involved in electron transport
Amico_0106	COG4658	electron transport chain
Amico_0107	COG4659	FMN binding
Amico_0108	COG4660	Part of a membrane complex involved in electron transport
Amico_0109	COG4657	Part of a membrane complex involved in electron transport
Amico_0110	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Amico_0110	COG2878	Part of a membrane complex involved in electron transport
Amico_0113	COG1477	protein flavinylation
Amico_0114	COG1115	amino acid carrier protein
Amico_0115	COG1615	UPF0182 protein
Amico_0118	COG3681	Belongs to the UPF0597 family
Amico_0119	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Amico_0120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Amico_0127	COG1203	CRISPR-associated helicase, Cas3
Amico_0130	COG2186	Transcriptional regulator
Amico_0131	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_0137	COG0281	malic enzyme
Amico_0140	COG1752	Esterase of the alpha-beta hydrolase superfamily
Amico_0146	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Amico_0147	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Amico_0150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Amico_0150	COG0425	Belongs to the sulfur carrier protein TusA family
Amico_0152	COG1196	nuclear chromosome segregation
Amico_0152	COG3264	Mechanosensitive ion channel
Amico_0153	COG4187	Peptidase family M20/M25/M40
Amico_0156	COG0559	Belongs to the binding-protein-dependent transport system permease family
Amico_0159	COG0410	ABC transporter
Amico_0162	COG1959	2 iron, 2 sulfur cluster binding
Amico_0164	COG0822	iron-sulfur transferase activity
Amico_0166	COG2818	Glycosylase
Amico_0167	COG2414	aldehyde ferredoxin oxidoreductase
Amico_0170	COG4953	penicillin-binding protein 1C
Amico_0172	COG0542	response to heat
Amico_0174	COG3290	protein histidine kinase activity
Amico_0175	COG4565	transcriptional regulatory protein
Amico_0183	COG1254	Belongs to the acylphosphatase family
Amico_0185	COG1509	lysine 2,3-aminomutase activity
Amico_0187	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amico_0188	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amico_0190	COG1659	Linocin_M18 bacteriocin protein
Amico_0194	COG1164	Oligoendopeptidase f
Amico_0195	COG0583	DNA-binding transcription factor activity
Amico_0196	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amico_0197	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Amico_0201	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_0202	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Amico_0205	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Amico_0206	COG3835	regulator
Amico_0210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amico_0210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_0211	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Amico_0212	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Amico_0216	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Amico_0220	COG1971	Probably functions as a manganese efflux pump
Amico_0224	COG0745	RESPONSE REGULATOR receiver
Amico_0225	COG3875	lactate racemase activity
Amico_0226	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amico_0227	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amico_0228	COG0019	diaminopimelate decarboxylase activity
Amico_0229	COG1757	Na H antiporter
Amico_0230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Amico_0232	COG0297	glycogen (starch) synthase activity
Amico_0234	COG1640	4-alpha-glucanotransferase
Amico_0235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Amico_0237	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Amico_0238	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Amico_0240	COG1811	Na channel or pump
Amico_0245	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Amico_0248	COG0438	transferase activity, transferring glycosyl groups
Amico_0249	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Amico_0251	COG0778	Nitroreductase
Amico_0251	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Amico_0252	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Amico_0253	COG0688	phosphatidylethanolamine metabolic process
Amico_0254	COG1183	phosphatidylcholine synthase activity
Amico_0255	COG0352	thiamine-phosphate diphosphorylase activity
Amico_0255	COG0351	phosphomethylpyrimidine kinase
Amico_0256	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Amico_0257	COG0352	thiamine-phosphate diphosphorylase activity
Amico_0259	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Amico_0260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amico_0261	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Amico_0262	COG3859	Proton-coupled thiamine transporter YuaJ
Amico_0264	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Amico_0266	COG0346	lactoylglutathione lyase activity
Amico_0267	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Amico_0269	COG4770	biotin carboxylase activity
Amico_0270	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Amico_0276	COG0038	chloride channel
Amico_0277	COG1301	dicarboxylic acid transport
Amico_0278	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Amico_0278	COG1752	Esterase of the alpha-beta hydrolase superfamily
Amico_0279	COG0442	prolyl-tRNA aminoacylation
Amico_0280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Amico_0280	COG0248	Ppx GppA phosphatase
Amico_0281	COG1283	sodium-dependent phosphate transmembrane transporter activity
Amico_0282	COG0704	Plays a role in the regulation of phosphate uptake
Amico_0283	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Amico_0287	COG0460	homoserine dehydrogenase
Amico_0289	COG0613	PHP domain protein
Amico_0290	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Amico_0292	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amico_0294	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Amico_0295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Amico_0298	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Amico_0299	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Amico_0300	COG2239	Acts as a magnesium transporter
Amico_0301	COG1309	transcriptional regulator
Amico_0308	COG2197	response regulator
Amico_0311	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Amico_0312	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Amico_0314	COG0250	Participates in transcription elongation, termination and antitermination
Amico_0315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Amico_0316	COG0081	regulation of translation
Amico_0317	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Amico_0318	COG0222	ribosome binding
Amico_0319	COG1515	deoxyribonuclease V activity
Amico_0321	COG4895	conserved protein (DUF2196)
Amico_0327	COG2962	Rard protein
Amico_0331	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Amico_0333	COG4206	TonB-dependent receptor
Amico_0335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amico_0336	COG1120	ATPase activity
Amico_0339	COG0811	peptide transport
Amico_0340	COG0733	neurotransmitter:sodium symporter activity
Amico_0341	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Amico_0344	COG0837	glucose binding
Amico_0347	COG0488	(ABC) transporter
Amico_0348	COG2271	Major facilitator Superfamily
Amico_0349	COG1278	Cold shock
Amico_0351	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Amico_0354	COG0697	spore germination
Amico_0355	COG3835	regulator
Amico_0357	COG1609	Transcriptional regulator
Amico_0358	COG1129	ABC transporter
Amico_0362	COG0778	Nitroreductase
Amico_0362	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Amico_0363	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Amico_0364	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amico_0366	COG1196	nuclear chromosome segregation
Amico_0366	COG0741	lytic transglycosylase activity
Amico_0366	COG0739	heme binding
Amico_0367	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Amico_0368	COG0436	Aminotransferase
Amico_0369	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Amico_0370	COG3481	metal-dependent phosphohydrolase, HD sub domain
Amico_0371	COG0564	pseudouridine synthase activity
Amico_0374	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Amico_0375	COG0017	Asparaginyl-tRNA synthetase
Amico_0376	COG0318	PFAM AMP-dependent synthetase and ligase
Amico_0377	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Amico_0377	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Amico_0380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amico_0382	COG1802	Transcriptional regulator
Amico_0384	COG2738	Putative neutral zinc metallopeptidase
Amico_0388	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Amico_0390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amico_0391	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Amico_0392	COG1546	Belongs to the CinA family
Amico_0392	COG1058	Belongs to the CinA family
Amico_0393	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Amico_0395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Amico_0397	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Amico_0398	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Amico_0399	COG2033	superoxide reductase activity
Amico_0402	COG0426	domain, Protein
Amico_0405	COG2270	Major facilitator Superfamily
Amico_0410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Amico_0412	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Amico_0413	COG1560	Kdo2-lipid A biosynthetic process
Amico_0415	COG0765	amino acid transport
Amico_0418	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amico_0422	COG2186	Transcriptional regulator
Amico_0423	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Amico_0424	COG1609	Transcriptional regulator
Amico_0427	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amico_0433	COG2205	protein histidine kinase activity
Amico_0434	COG2116	formate transmembrane transporter activity
Amico_0438	COG2096	Adenosyltransferase
Amico_0439	COG1414	Transcriptional regulator
Amico_0441	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Amico_0449	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Amico_0450	COG0732	type I restriction modification DNA specificity domain
Amico_0451	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Amico_0454	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Amico_0457	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_0459	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_0461	COG0626	cystathionine gamma-synthase activity
Amico_0462	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Amico_0463	COG0671	phosphoesterase, PA-phosphatase related
Amico_0465	COG0444	Belongs to the ABC transporter superfamily
Amico_0467	COG0601	transmembrane transport
Amico_0468	COG0747	negative chemotaxis
Amico_0472	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Amico_0477	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Amico_0478	COG0668	transmembrane transport
Amico_0488	COG1136	(ABC) transporter
Amico_0489	COG1136	(ABC) transporter
Amico_0489	COG0577	efflux transmembrane transporter activity
Amico_0491	COG0460	homoserine dehydrogenase
Amico_0494	COG1278	Cold shock
Amico_0496	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Amico_0497	COG1984	allophanate hydrolase subunit 2
Amico_0498	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Amico_0499	COG4336	lyase activity
Amico_0500	COG0235	Class ii aldolase
Amico_0511	COG1802	Transcriptional regulator
Amico_0515	COG0045	succinate-CoA ligase (ADP-forming) activity
Amico_0516	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Amico_0519	COG0460	homoserine dehydrogenase
Amico_0523	COG0251	oxidation-reduction process
Amico_0524	COG2855	membrane
Amico_0525	COG0583	DNA-binding transcription factor activity
Amico_0526	COG0133	tryptophan synthase activity
Amico_0528	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Amico_0530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Amico_0532	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Amico_0532	COG2199	diguanylate cyclase activity
Amico_0535	COG2183	response to ionizing radiation
Amico_0537	COG2359	stage V sporulation protein S
Amico_0538	COG0124	histidyl-tRNA synthetase
Amico_0539	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Amico_0540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Amico_0544	COG0583	DNA-binding transcription factor activity
Amico_0545	COG0442	prolyl-tRNA aminoacylation
Amico_0550	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Amico_0551	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Amico_0552	COG0228	four-way junction DNA binding
Amico_0553	COG1837	Belongs to the UPF0109 family
Amico_0554	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Amico_0555	COG4752	Belongs to the RNA methyltransferase TrmD family
Amico_0555	COG0336	Belongs to the RNA methyltransferase TrmD family
Amico_0556	COG0335	large ribosomal subunit rRNA binding
Amico_0558	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Amico_0560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amico_0560	COG1042	CoA-binding domain protein
Amico_0560	COG0045	succinate-CoA ligase (ADP-forming) activity
Amico_0561	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Amico_0562	COG4463	regulation of RNA biosynthetic process
Amico_0563	COG0542	response to heat
Amico_0568	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Amico_0570	COG0733	neurotransmitter:sodium symporter activity
Amico_0572	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Amico_0573	COG0083	homoserine kinase activity
Amico_0576	COG1137	ATPase activity
Amico_0581	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Amico_0582	COG0459	protein refolding
Amico_0583	COG0519	Catalyzes the synthesis of GMP from XMP
Amico_0583	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Amico_0584	COG0628	permease
Amico_0586	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Amico_0587	COG0358	DNA primase activity
Amico_0588	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Amico_0589	COG0148	phosphopyruvate hydratase activity
Amico_0590	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Amico_0592	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Amico_0593	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Amico_0594	COG0535	radical SAM domain protein
Amico_0596	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Amico_0596	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Amico_0599	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amico_0600	COG2003	Belongs to the UPF0758 family
Amico_0601	COG1077	Cell shape determining protein MreB Mrl
Amico_0604	COG0768	penicillin binding
Amico_0605	COG0850	regulation of cytokinetic process
Amico_0606	COG2894	cell division
Amico_0607	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Amico_0608	COG0772	Belongs to the SEDS family
Amico_0611	COG1530	ribonuclease E activity
Amico_0613	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Amico_0614	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Amico_0615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amico_0615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amico_0616	COG0084	hydrolase, TatD family'
Amico_0617	COG0343	queuine tRNA-ribosyltransferase activity
Amico_0618	COG0009	L-threonylcarbamoyladenylate synthase
Amico_0619	COG0085	RNA polymerase activity
Amico_0620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Amico_0622	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Amico_0624	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Amico_0625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Amico_0626	COG0051	transcription antitermination factor activity, RNA binding
Amico_0627	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Amico_0628	COG0088	Forms part of the polypeptide exit tunnel
Amico_0629	COG0089	rRNA binding
Amico_0630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Amico_0631	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Amico_0632	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Amico_0633	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Amico_0634	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Amico_0635	COG0255	Belongs to the universal ribosomal protein uL29 family
Amico_0636	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Amico_0637	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Amico_0638	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Amico_0639	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Amico_0640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Amico_0641	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Amico_0642	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Amico_0643	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Amico_0644	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Amico_0645	COG1841	ribosomal large subunit assembly
Amico_0647	COG0201	protein transport
Amico_0649	COG0024	Methionine aminopeptidase
Amico_0651	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Amico_0652	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Amico_0653	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Amico_0654	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Amico_0655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Amico_0656	COG0202	RNA polymerase activity
Amico_0657	COG0203	ribosomal protein L17
Amico_0658	COG1122	ATPase activity
Amico_0660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Amico_0661	COG0101	tRNA pseudouridine synthase activity
Amico_0662	COG1077	Cell shape determining protein MreB Mrl
Amico_0667	COG0454	-acetyltransferase
Amico_0677	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Amico_0677	COG0140	phosphoribosyl-ATP diphosphatase activity
Amico_0678	COG0107	imidazoleglycerol-phosphate synthase activity
Amico_0679	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Amico_0681	COG0131	Imidazoleglycerol-phosphate dehydratase
Amico_0682	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Amico_0683	COG0124	histidyl-tRNA synthetase
Amico_0684	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Amico_0685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Amico_0687	COG0330	HflC and HflK could
Amico_0690	COG0268	Binds directly to 16S ribosomal RNA
Amico_0691	COG1199	ATP-dependent helicase activity
Amico_0693	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Amico_0694	COG0706	membrane insertase activity
Amico_0695	COG1847	R3H domain protein
Amico_0699	COG0745	RESPONSE REGULATOR receiver
Amico_0700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Amico_0701	COG1185	polyribonucleotide nucleotidyltransferase activity
Amico_0702	COG0756	dUTP diphosphatase activity
Amico_0703	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Amico_0704	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Amico_0706	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Amico_0707	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Amico_0708	COG0569	domain protein
Amico_0709	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Amico_0710	COG0072	phenylalanine-tRNA ligase activity
Amico_0710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amico_0714	COG1193	negative regulation of DNA recombination
Amico_0716	COG1414	Transcriptional regulator
Amico_0722	COG0254	rRNA binding
Amico_0723	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Amico_0724	COG3872	metal-dependent enzyme
Amico_0725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Amico_0726	COG2890	protein-(glutamine-N5) methyltransferase activity
Amico_0727	COG0492	ferredoxin-NADP+ reductase activity
Amico_0731	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Amico_0735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Amico_0736	COG3457	Alanine racemase
Amico_0739	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Amico_0740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Amico_0741	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Amico_0743	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Amico_0745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Amico_0747	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Amico_0748	COG0193	aminoacyl-tRNA hydrolase activity
Amico_0749	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Amico_0750	COG3956	TIGRFAM MazG family protein
Amico_0752	COG1702	phosphate starvation-inducible protein PhoH
Amico_0753	COG1480	7TM receptor with intracellular HD hydrolase
Amico_0755	COG4536	flavin adenine dinucleotide binding
Amico_0756	COG0295	cytidine deaminase activity
Amico_0757	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Amico_0759	COG0752	glycyl-tRNA synthetase alpha subunit
Amico_0760	COG0751	glycine-tRNA ligase activity
Amico_0762	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Amico_0763	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Amico_0763	COG0574	Belongs to the PEP-utilizing enzyme family
Amico_0779	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Amico_0780	COG0556	nucleotide-excision repair
Amico_0782	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Amico_0783	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Amico_0786	COG0444	Belongs to the ABC transporter superfamily
Amico_0787	COG4608	Belongs to the ABC transporter superfamily
Amico_0790	COG0736	holo-[acyl-carrier-protein] synthase activity
Amico_0791	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Amico_0791	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Amico_0792	COG0802	atpase or kinase
Amico_0793	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Amico_0795	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amico_0795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amico_0796	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amico_0800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Amico_0802	COG1269	ATP hydrolysis coupled proton transport
Amico_0803	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Amico_0804	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Amico_0807	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Amico_0809	COG1394	ATPase activity, coupled to movement of substances
Amico_0810	COG2001	Belongs to the MraZ family
Amico_0811	COG0275	rRNA processing
Amico_0814	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Amico_0815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Amico_0816	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Amico_0817	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Amico_0819	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Amico_0820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Amico_0821	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Amico_0824	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Amico_0828	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Amico_0830	COG0521	Mo-molybdopterin cofactor biosynthetic process
Amico_0831	COG1660	Displays ATPase and GTPase activities
Amico_0832	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Amico_0833	COG1481	regulation of sporulation
Amico_0835	COG0126	phosphoglycerate kinase activity
Amico_0840	COG0799	negative regulation of ribosome biogenesis
Amico_0841	COG1316	TRANSCRIPTIONal
Amico_0842	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Amico_0843	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Amico_0846	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Amico_0847	COG0497	DNA recombination
Amico_0848	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Amico_0849	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Amico_0850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Amico_0852	COG1722	exodeoxyribonuclease VII activity
Amico_0853	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Amico_0855	COG1674	ftsk spoiiie
Amico_0856	COG0312	modulator of DNA gyrase
Amico_0858	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Amico_0860	COG3885	ferrous iron binding
Amico_0860	COG2078	PFAM AMMECR1 domain protein
Amico_0861	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Amico_0862	COG2385	sporulation resulting in formation of a cellular spore
Amico_0862	COG2247	cell wall binding repeat
Amico_0864	COG2255	four-way junction helicase activity
Amico_0865	COG0632	four-way junction helicase activity
Amico_0866	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Amico_0867	COG0217	transcriptional regulatory protein
Amico_0868	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Amico_0870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Amico_0871	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Amico_0872	COG0750	zinc metalloprotease
Amico_0873	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Amico_0874	COG0575	Belongs to the CDS family
Amico_0875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Amico_0876	COG1573	uracil-dna glycosylase
Amico_0879	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Amico_0880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Amico_0881	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Amico_0882	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Amico_0883	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Amico_0886	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Amico_0888	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Amico_0888	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Amico_0893	COG0285	dihydrofolate synthase activity
Amico_0894	COG0525	valine-tRNA ligase activity
Amico_0895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Amico_0896	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Amico_0897	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Amico_0898	COG0740	serine-type endopeptidase activity
Amico_0902	COG0402	S-adenosylhomocysteine deaminase activity
Amico_0905	COG1704	LemA family
Amico_0908	COG3842	ATPase activity
Amico_0910	COG1840	ABC-type Fe3 transport system, periplasmic component
Amico_0913	COG1760	l-serine dehydratase
Amico_0926	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_0929	COG4249	Peptidase C14 caspase catalytic subunit p20
Amico_0941	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Amico_0942	COG1408	metallophosphoesterase
Amico_0949	COG0305	Participates in initiation and elongation during chromosome replication
Amico_0956	COG4948	Mandelate Racemase Muconate Lactonizing
Amico_0960	COG0564	pseudouridine synthase activity
Amico_0961	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Amico_0964	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Amico_0966	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Amico_0967	COG0196	riboflavin kinase activity
Amico_0968	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Amico_0969	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Amico_0970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Amico_0972	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Amico_0974	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Amico_0975	COG0195	Participates in both transcription termination and antitermination
Amico_0976	COG0779	Required for maturation of 30S ribosomal subunits
Amico_0977	COG0517	IMP dehydrogenase activity
Amico_0977	COG0516	GMP reductase activity
Amico_0978	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Amico_0979	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Amico_0979	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Amico_0980	COG4956	integral membrane protein (PIN domain superfamily)
Amico_0981	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Amico_0982	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Amico_0983	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Amico_0984	COG1394	ATPase activity, coupled to movement of substances
Amico_0985	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Amico_0986	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Amico_0991	COG1269	ATP hydrolysis coupled proton transport
Amico_0994	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Amico_0995	COG1473	amidohydrolase
Amico_0996	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Amico_0998	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Amico_0998	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Amico_1000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Amico_1000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Amico_1001	COG0322	excinuclease ABC activity
Amico_1005	COG0500	methyltransferase
Amico_1008	COG1592	Rubrerythrin
Amico_1011	COG0739	heme binding
Amico_1013	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Amico_1014	COG4974	Belongs to the 'phage' integrase family
Amico_1015	COG0494	nUDIX hydrolase
Amico_1018	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amico_1021	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Amico_1023	COG0539	negative regulation of cytoplasmic translation
Amico_1024	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Amico_1025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Amico_1026	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Amico_1027	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Amico_1028	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Amico_1030	COG0402	S-adenosylhomocysteine deaminase activity
Amico_1031	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Amico_1032	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Amico_1033	COG1570	exodeoxyribonuclease VII activity
Amico_1034	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Amico_1038	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Amico_1040	COG4496	protein, YerC YecD
Amico_1042	COG1067	ATP-dependent peptidase activity
Amico_1043	COG0482	sulfurtransferase activity
Amico_1044	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Amico_1046	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Amico_1048	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Amico_1050	COG0552	protein localization to endoplasmic reticulum
Amico_1051	COG1774	PSP1 C-terminal conserved region
Amico_1052	COG0470	DNA polymerase III
Amico_1053	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Amico_1054	COG0750	zinc metalloprotease
Amico_1056	COG0709	Synthesizes selenophosphate from selenide and ATP
Amico_1059	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Amico_1060	COG0571	ribonuclease III activity
Amico_1061	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Amico_1062	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amico_1064	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Amico_1065	COG2070	2-Nitropropane dioxygenase
Amico_1066	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amico_1067	COG0416	fatty acid biosynthetic process
Amico_1068	COG2030	dehydratase
Amico_1069	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Amico_1071	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Amico_1072	COG1323	Belongs to the UPF0348 family
Amico_1073	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Amico_1074	COG0742	ribosomal rna small subunit methyltransferase
Amico_1075	COG1720	tRNA m6t6A37 methyltransferase activity
Amico_1076	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Amico_1077	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Amico_1077	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amico_1077	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amico_1077	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amico_1078	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Amico_1080	COG1160	GTP binding
Amico_1081	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Amico_1082	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Amico_1084	COG0194	GDP metabolic process
Amico_1085	COG2052	Domain of unknown function (DUF370)
Amico_1086	COG1561	YicC-like family, N-terminal region
Amico_1087	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Amico_1088	COG0318	PFAM AMP-dependent synthetase and ligase
Amico_1088	COG0204	Acyl-transferase
Amico_1089	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Amico_1090	COG1187	pseudouridine synthase activity
Amico_1091	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Amico_1093	COG0180	Tryptophanyl-tRNA synthetase
Amico_1094	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Amico_1125	COG0582	viral genome integration into host DNA
Amico_1131	COG1484	DNA-dependent DNA replication
Amico_1133	COG0756	dUTP diphosphatase activity
Amico_1142	COG1396	sequence-specific DNA binding
Amico_1147	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Amico_1151	COG0582	viral genome integration into host DNA
Amico_1152	COG1141	Ferredoxin
Amico_1153	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Amico_1154	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Amico_1157	COG1921	L-seryl-tRNASec selenium transferase activity
Amico_1161	COG0481	GTPase activity
Amico_1162	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Amico_1163	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Amico_1164	COG0047	phosphoribosylformylglycinamidine synthase activity
Amico_1166	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Amico_1167	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Amico_1168	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Amico_1169	COG0138	bifunctional purine biosynthesis protein purh
Amico_1170	COG0151	Belongs to the GarS family
Amico_1171	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Amico_1174	COG0137	argininosuccinate synthase activity
Amico_1175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Amico_1176	COG1994	Peptidase M50
Amico_1178	COG0237	dephospho-CoA kinase activity
Amico_1179	COG0210	DNA helicase
Amico_1180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Amico_1182	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Amico_1184	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Amico_1185	COG2252	PERMEase
Amico_1186	COG0233	cytoplasmic translational termination
Amico_1187	COG0528	UMP kinase activity
Amico_1188	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Amico_1189	COG0052	Belongs to the universal ribosomal protein uS2 family
Amico_1190	COG1937	Protein conserved in bacteria
Amico_1191	COG1881	PFAM PEBP family protein
Amico_1193	COG2195	Cleaves the N-terminal amino acid of tripeptides
Amico_1194	COG2239	Acts as a magnesium transporter
Amico_1200	COG2201	protein-glutamate methylesterase activity
Amico_1205	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Amico_1208	COG2197	response regulator
Amico_1209	COG2203	Gaf domain
Amico_1209	COG4585	Histidine kinase
Amico_1210	COG0183	Belongs to the thiolase family
Amico_1211	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Amico_1212	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Amico_1215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Amico_1217	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Amico_1221	COG3706	GGDEF domain
Amico_1224	COG2235	arginine
Amico_1227	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Amico_1228	COG3949	Membrane
Amico_1229	COG1592	Rubrerythrin
Amico_1234	COG0003	Pfam Anion-transporting ATPase
Amico_1238	COG1362	aminopeptidase activity
Amico_1239	COG2379	hydroxypyruvate reductase
Amico_1249	COG1335	isochorismatase
Amico_1250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Amico_1251	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amico_1252	COG2423	ornithine cyclodeaminase activity
Amico_1257	COG0494	nUDIX hydrolase
Amico_1259	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Amico_1259	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Amico_1261	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Amico_1262	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amico_1263	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Amico_1264	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Amico_1264	COG3261	NADH dehydrogenase
Amico_1265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amico_1265	COG0649	NAD binding
Amico_1266	COG3260	NADH ubiquinone oxidoreductase 20
Amico_1268	COG0651	ATP synthesis coupled electron transport
Amico_1271	COG2111	Na H antiporter
Amico_1271	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Amico_1273	COG1320	monovalent cation:proton antiporter activity
Amico_1274	COG2212	antiporter activity
Amico_1275	COG1863	multisubunit Na H antiporter MnhE subunit
Amico_1280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Amico_1281	COG0598	Magnesium transport protein CorA
Amico_1287	COG0569	domain protein
Amico_1291	COG1253	flavin adenine dinucleotide binding
Amico_1294	COG1346	cytolysis
Amico_1295	COG1380	Effector of murein hydrolase LrgA
Amico_1296	COG0251	oxidation-reduction process
Amico_1300	COG0179	Fumarylacetoacetate (FAA) hydrolase
Amico_1301	COG0473	3-isopropylmalate dehydrogenase activity
Amico_1302	COG1802	Transcriptional regulator
Amico_1303	COG1454	alcohol dehydrogenase
Amico_1304	COG3875	lactate racemase activity
Amico_1306	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amico_1307	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1309	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Amico_1310	COG2186	Transcriptional regulator
Amico_1313	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amico_1314	COG1144	Oxidoreductase
Amico_1315	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amico_1316	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amico_1321	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1324	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Amico_1325	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Amico_1332	COG0426	domain, Protein
Amico_1333	COG3189	MarR family transcriptional regulator
Amico_1334	COG3093	addiction module antidote protein HigA
Amico_1337	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Amico_1338	COG2814	Major facilitator Superfamily
Amico_1339	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Amico_1340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_1342	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1346	COG1309	transcriptional regulator
Amico_1349	COG1136	(ABC) transporter
Amico_1350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Amico_1352	COG1335	isochorismatase
Amico_1357	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Amico_1361	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Amico_1362	COG2197	response regulator
Amico_1363	COG0037	tRNA processing
Amico_1364	COG0719	Fe-S assembly protein
Amico_1365	COG0396	ATPase activity
Amico_1366	COG0166	Belongs to the GPI family
Amico_1368	COG0543	2 iron, 2 sulfur cluster binding
Amico_1371	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Amico_1372	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Amico_1373	COG0154	amidase activity
Amico_1374	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Amico_1375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Amico_1376	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Amico_1378	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Amico_1379	COG0658	competence protein
Amico_1379	COG2333	competence protein COMEC
Amico_1383	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Amico_1384	COG1773	rubredoxin
Amico_1385	COG0006	proline dipeptidase activity
Amico_1386	COG0709	Synthesizes selenophosphate from selenide and ATP
Amico_1387	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Amico_1388	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Amico_1389	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Amico_1390	COG1115	amino acid carrier protein
Amico_1394	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Amico_1400	COG0733	neurotransmitter:sodium symporter activity
Amico_1402	COG0409	Hydrogenase expression formation protein
Amico_1404	COG1692	metallophosphoesterase
Amico_1405	COG1418	mRNA catabolic process
Amico_1407	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Amico_1408	COG3599	regulation of cell shape
Amico_1410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Amico_1412	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Amico_1413	COG1469	GTP cyclohydrolase I activity
Amico_1414	COG0720	synthase
Amico_1417	COG0305	Participates in initiation and elongation during chromosome replication
Amico_1420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Amico_1421	COG0629	single-stranded DNA binding
Amico_1422	COG0360	Binds together with S18 to 16S ribosomal RNA
Amico_1424	COG0018	arginyl-trna synthetase
Amico_1426	COG0653	protein targeting
Amico_1427	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amico_1428	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Amico_1432	COG0559	Belongs to the binding-protein-dependent transport system permease family
Amico_1434	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Amico_1437	COG0537	adenosine 5'-monophosphoramidase activity
Amico_1438	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amico_1440	COG0484	heat shock protein binding
Amico_1442	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Amico_1443	COG1420	regulation of RNA biosynthetic process
Amico_1445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Amico_1446	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Amico_1449	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amico_1452	COG1966	Carbon starvation protein
Amico_1454	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Amico_1455	COG2861	carbohydrate metabolic process
Amico_1456	COG0793	Belongs to the peptidase S41A family
Amico_1457	COG0739	heme binding
Amico_1458	COG2177	Part of the ABC transporter FtsEX involved in
Amico_1459	COG2884	Cell division ATP-binding protein ftsE
Amico_1460	COG3958	Transketolase
Amico_1461	COG3959	Transketolase, thiamine diphosphate binding domain
Amico_1464	COG0424	maF-like protein
Amico_1466	COG1968	undecaprenyl-diphosphatase activity
Amico_1467	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Amico_1468	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Amico_1469	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amico_1474	COG0504	CTP synthase activity
Amico_1476	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Amico_1481	COG0205	6-phosphofructokinase activity
Amico_1484	COG0497	DNA recombination
Amico_1486	COG0859	PFAM glycosyl transferase family 9
Amico_1487	COG0438	transferase activity, transferring glycosyl groups
Amico_1488	COG0438	transferase activity, transferring glycosyl groups
Amico_1490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Amico_1492	COG1519	Transferase
Amico_1494	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Amico_1495	COG1663	tetraacyldisaccharide 4'-kinase activity
Amico_1496	COG1132	(ABC) transporter
Amico_1498	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Amico_1499	COG3494	Protein of unknown function (DUF1009)
Amico_1501	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Amico_1502	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Amico_1503	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Amico_1504	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Amico_1505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Amico_1509	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Amico_1510	COG0406	alpha-ribazole phosphatase activity
Amico_1514	COG1185	polyribonucleotide nucleotidyltransferase activity
Amico_1515	COG2201	protein-glutamate methylesterase activity
Amico_1517	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Amico_1518	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Amico_1521	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Amico_1524	COG0606	chelatase, subunit chli
Amico_1525	COG0792	nuclease activity
Amico_1526	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Amico_1527	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Amico_1528	COG0681	Belongs to the peptidase S26 family
Amico_1532	COG0824	Thioesterase
Amico_1534	COG2239	Acts as a magnesium transporter
Amico_1535	COG2423	ornithine cyclodeaminase activity
Amico_1537	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Amico_1538	COG3404	Formiminotransferase-cyclodeaminase
Amico_1540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1541	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_1542	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amico_1543	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amico_1545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Amico_1546	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Amico_1549	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Amico_1550	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Amico_1553	COG3259	Nickel-dependent hydrogenase
Amico_1554	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Amico_1555	COG3383	formate dehydrogenase (NAD+) activity
Amico_1559	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Amico_1560	COG4662	Binding-protein-dependent transport system inner membrane component
Amico_1561	COG2998	abc-type tungstate transport system, permease component
Amico_1570	COG1744	ABC transporter substrate-binding protein PnrA-like
Amico_1571	COG0737	Belongs to the 5'-nucleotidase family
Amico_1572	COG1573	uracil-dna glycosylase
Amico_1577	COG1840	ABC-type Fe3 transport system, periplasmic component
Amico_1578	COG0095	Lipoate-protein ligase
Amico_1581	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1582	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1583	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Amico_1584	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Amico_1585	COG0508	dehydrogenase complex catalyzes the overall conversion of
Amico_1588	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1590	COG0022	dehydrogenase e1 component
Amico_1591	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Amico_1593	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Amico_1596	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Amico_1597	COG0284	orotidine-5'-phosphate decarboxylase activity
Amico_1598	COG0167	dihydroorotate dehydrogenase activity
Amico_1599	COG0543	2 iron, 2 sulfur cluster binding
Amico_1600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Amico_1601	COG0540	Belongs to the ATCase OTCase family
Amico_1602	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Amico_1603	COG0436	Aminotransferase
Amico_1604	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Amico_1605	COG1414	Transcriptional regulator
Amico_1608	COG0697	spore germination
Amico_1609	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Amico_1611	COG0318	PFAM AMP-dependent synthetase and ligase
Amico_1614	COG1691	(AIR) carboxylase
Amico_1616	COG1473	amidohydrolase
Amico_1621	COG0745	RESPONSE REGULATOR receiver
Amico_1621	COG3706	GGDEF domain
Amico_1622	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Amico_1627	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Amico_1638	COG1331	Highly conserved protein containing a thioredoxin domain
Amico_1640	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Amico_1642	COG0460	homoserine dehydrogenase
Amico_1645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Amico_1647	COG0187	DNA topoisomerase II activity
Amico_1649	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Amico_1652	COG1802	Transcriptional regulator
Amico_1654	COG1473	amidohydrolase
Amico_1656	COG0747	negative chemotaxis
Amico_1658	COG4608	Belongs to the ABC transporter superfamily
Amico_1659	COG0444	Belongs to the ABC transporter superfamily
Amico_1661	COG0601	transmembrane transport
Amico_1662	COG0617	tRNA 3'-terminal CCA addition
Amico_1663	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Amico_1664	COG3875	lactate racemase activity
Amico_1665	COG0800	Aldolase
Amico_1667	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Amico_1668	COG2011	ABC-type metal ion transport system permease component
Amico_1670	COG4948	Mandelate Racemase Muconate Lactonizing
Amico_1673	COG1414	Transcriptional regulator
Amico_1676	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1677	COG2721	sulfolactate sulfo-lyase activity
Amico_1678	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Amico_1679	COG0573	inorganic phosphate transmembrane transporter activity
Amico_1680	COG0581	inorganic phosphate transmembrane transporter activity
Amico_1681	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Amico_1683	COG0745	RESPONSE REGULATOR receiver
Amico_1684	COG5002	protein histidine kinase activity
Amico_1687	COG1408	metallophosphoesterase
Amico_1688	COG1414	Transcriptional regulator
Amico_1691	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1695	COG2364	Membrane
Amico_1696	COG0405	Gamma-glutamyltransferase
Amico_1698	COG1785	Belongs to the alkaline phosphatase family
Amico_1701	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_1703	COG0066	3-isopropylmalate dehydratase activity
Amico_1716	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Amico_1717	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Amico_1723	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amico_1725	COG1028	Short-chain dehydrogenase reductase Sdr
Amico_1734	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Amico_1750	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amico_1751	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1756	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1757	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amico_1762	COG3123	guanosine phosphorylase activity
Amico_1764	COG0628	permease
Amico_1765	COG1921	L-seryl-tRNASec selenium transferase activity
Amico_1766	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Amico_1767	COG0446	pyridine nucleotide-disulphide oxidoreductase
Amico_1768	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amico_1774	COG1278	Cold shock
Amico_1776	COG1970	mechanosensitive ion channel activity
Amico_1778	COG0601	transmembrane transport
Amico_1779	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amico_1783	COG0328	RNA-DNA hybrid ribonuclease activity
Amico_1783	COG0406	alpha-ribazole phosphatase activity
Amico_1784	COG1091	dTDP-4-dehydrorhamnose reductase activity
Amico_1785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Amico_1786	COG0156	8-amino-7-oxononanoate synthase activity
Amico_1790	COG0281	malic enzyme
Amico_1791	COG0318	PFAM AMP-dependent synthetase and ligase
Amico_1792	COG0519	Catalyzes the synthesis of GMP from XMP
Amico_1792	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Amico_1793	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Amico_1795	COG1473	amidohydrolase
Amico_1800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amico_1801	COG0443	Heat shock 70 kDa protein
Amico_1809	COG0420	3'-5' exonuclease activity
Amico_1813	COG1827	regulation of RNA biosynthetic process
Amico_1815	COG2199	diguanylate cyclase activity
Amico_1815	COG2203	Gaf domain
Amico_1818	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Amico_1823	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Amico_1826	COG1047	Peptidyl-prolyl cis-trans
Amico_1829	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amico_1831	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amico_1831	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amico_1832	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Amico_1836	COG1414	Transcriptional regulator
Amico_1837	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Amico_1839	COG3426	butyrate kinase activity
Amico_1840	COG0280	phosphate acetyltransferase
Amico_1841	COG0280	phosphate acetyltransferase
Amico_1842	COG3426	butyrate kinase activity
Amico_1843	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Amico_1848	COG1739	Uncharacterized protein family UPF0029
Amico_1851	COG1475	DNA binding
Amico_1852	COG1192	Involved in chromosome partitioning
Amico_1853	COG0357	Ribosomal RNA small subunit methyltransferase G
Amico_1854	COG1525	nuclease
Amico_1859	COG1473	amidohydrolase
Amico_1860	COG1473	amidohydrolase
Amico_1861	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Amico_1862	COG1121	(ABC) transporter
Amico_1863	COG0803	Belongs to the bacterial solute-binding protein 9 family
Amico_1871	COG4585	Histidine kinase
Amico_1873	COG2414	aldehyde ferredoxin oxidoreductase
Amico_1876	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Amico_1877	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amico_1878	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amico_1881	COG1028	Short-chain dehydrogenase reductase Sdr
Amico_1882	COG0667	Aldo Keto reductase
Amico_1885	COG1228	amidohydrolase
Amico_1886	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Amico_1888	COG1840	ABC-type Fe3 transport system, periplasmic component
Amico_1889	COG1178	ABC-type Fe3 transport system permease component
Amico_1890	COG3842	ATPase activity
Amico_1891	COG1924	4 iron, 4 sulfur cluster binding
Amico_1896	COG2217	Heavy metal translocating P-type atpase
Amico_1900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Amico_1902	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Amico_1903	COG2195	Cleaves the N-terminal amino acid of tripeptides
Amico_1905	COG2986	histidine ammonia-lyase
Amico_1906	COG1151	hydroxylamine reductase activity
Amico_1908	COG1959	2 iron, 2 sulfur cluster binding
Amico_1909	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine