locus-tag	class	description
Adeg_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Adeg_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Adeg_0005	COG0187	DNA topoisomerase II activity
Adeg_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Adeg_0007	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Adeg_0008	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Adeg_0009	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Adeg_0010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Adeg_0011	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Adeg_0012	COG0582	viral genome integration into host DNA
Adeg_0027	COG0517	IMP dehydrogenase activity
Adeg_0034	COG0247	lactate metabolic process
Adeg_0035	COG2920	part of a sulfur-relay system
Adeg_0036	COG1797	cobyrinic acid a,c-diamide synthase activity
Adeg_0037	COG1324	tolerance protein
Adeg_0042	COG3773	Cell wall hydrolase
Adeg_0042	COG3409	Peptidoglycan-binding domain 1 protein
Adeg_0046	COG3464	Transposase
Adeg_0047	COG1522	sequence-specific DNA binding
Adeg_0048	COG0436	Aminotransferase
Adeg_0050	COG0018	arginyl-trna synthetase
Adeg_0051	COG0504	CTP synthase activity
Adeg_0052	COG0616	signal peptide processing
Adeg_0054	COG2204	response regulator
Adeg_0057	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Adeg_0058	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Adeg_0061	COG0254	rRNA binding
Adeg_0062	COG3872	metal-dependent enzyme
Adeg_0063	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Adeg_0064	COG2890	protein-(glutamine-N5) methyltransferase activity
Adeg_0065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Adeg_0067	COG0009	L-threonylcarbamoyladenylate synthase
Adeg_0068	COG1971	Probably functions as a manganese efflux pump
Adeg_0070	COG0698	ribose 5-phosphate isomerase
Adeg_0071	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Adeg_0074	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Adeg_0077	COG0356	it plays a direct role in the translocation of protons across the membrane
Adeg_0078	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Adeg_0079	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Adeg_0080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Adeg_0081	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Adeg_0082	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Adeg_0083	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Adeg_0084	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Adeg_0085	COG2385	sporulation resulting in formation of a cellular spore
Adeg_0086	COG1609	Transcriptional regulator
Adeg_0087	COG3693	PFAM glycoside hydrolase, family 10
Adeg_0096	COG0109	protoheme IX farnesyltransferase activity
Adeg_0097	COG1846	Transcriptional regulator
Adeg_0098	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeg_0100	COG2814	Major facilitator Superfamily
Adeg_0104	COG0438	transferase activity, transferring glycosyl groups
Adeg_0105	COG0438	transferase activity, transferring glycosyl groups
Adeg_0111	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Adeg_0112	COG1301	dicarboxylic acid transport
Adeg_0113	COG3314	Sporulation integral membrane protein YlbJ
Adeg_0115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Adeg_0116	COG0742	ribosomal rna small subunit methyltransferase
Adeg_0117	COG1396	sequence-specific DNA binding
Adeg_0118	COG1476	TRANSCRIPTIONal
Adeg_0124	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Adeg_0126	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Adeg_0129	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Adeg_0134	COG1702	phosphate starvation-inducible protein PhoH
Adeg_0135	COG1480	7TM receptor with intracellular HD hydrolase
Adeg_0136	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Adeg_0137	COG0295	cytidine deaminase activity
Adeg_0138	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Adeg_0142	COG0537	adenosine 5'-monophosphoramidase activity
Adeg_0143	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Adeg_0144	COG0352	thiamine-phosphate diphosphorylase activity
Adeg_0145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Adeg_0146	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Adeg_0147	COG0802	atpase or kinase
Adeg_0148	COG1214	PFAM Peptidase M22, glycoprotease
Adeg_0149	COG0456	acetyltransferase
Adeg_0150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Adeg_0152	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Adeg_0156	COG3383	formate dehydrogenase (NAD+) activity
Adeg_0159	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Adeg_0161	COG0459	protein refolding
Adeg_0163	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Adeg_0166	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Adeg_0169	COG0281	malic enzyme
Adeg_0170	COG0037	tRNA processing
Adeg_0171	COG2855	membrane
Adeg_0172	COG3852	Histidine kinase
Adeg_0173	COG2204	response regulator
Adeg_0174	COG0589	response to stress
Adeg_0177	COG1067	ATP-dependent peptidase activity
Adeg_0178	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Adeg_0179	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Adeg_0180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Adeg_0181	COG1492	cobalamin metabolic process
Adeg_0182	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Adeg_0183	COG1797	cobyrinic acid a,c-diamide synthase activity
Adeg_0185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Adeg_0186	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Adeg_0188	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Adeg_0189	COG0860	N-Acetylmuramoyl-L-alanine amidase
Adeg_0190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Adeg_0191	COG0724	RNA recognition motif
Adeg_0192	COG0799	negative regulation of ribosome biogenesis
Adeg_0193	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Adeg_0197	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Adeg_0198	COG1686	Belongs to the peptidase S11 family
Adeg_0204	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Adeg_0206	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Adeg_0207	COG0010	Belongs to the arginase family
Adeg_0208	COG0482	sulfurtransferase activity
Adeg_0210	COG0557	exoribonuclease II activity
Adeg_0211	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Adeg_0212	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Adeg_0213	COG0860	N-Acetylmuramoyl-L-alanine amidase
Adeg_0218	COG3885	ferrous iron binding
Adeg_0218	COG2078	PFAM AMMECR1 domain protein
Adeg_0222	COG0129	dihydroxy-acid dehydratase activity
Adeg_0223	COG0028	Belongs to the TPP enzyme family
Adeg_0225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Adeg_0226	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Adeg_0227	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Adeg_0228	COG0066	3-isopropylmalate dehydratase activity
Adeg_0229	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Adeg_0230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Adeg_0231	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Adeg_0232	COG3546	catalase activity
Adeg_0239	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Adeg_0240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Adeg_0243	COG0835	chemotaxis
Adeg_0244	COG0643	Histidine kinase
Adeg_0244	COG2198	Histidine kinase
Adeg_0251	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Adeg_0252	COG0463	Glycosyl transferase, family 2
Adeg_0252	COG0457	Tetratricopeptide repeat
Adeg_0254	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Adeg_0278	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Adeg_0280	COG2442	InterPro IPR007367
Adeg_0281	COG1120	ATPase activity
Adeg_0282	COG3383	formate dehydrogenase (NAD+) activity
Adeg_0282	COG0243	molybdopterin cofactor binding
Adeg_0284	COG3064	Membrane
Adeg_0284	COG0437	4 iron, 4 sulfur cluster binding
Adeg_0287	COG1028	Short-chain dehydrogenase reductase Sdr
Adeg_0291	COG3064	Membrane
Adeg_0291	COG0437	4 iron, 4 sulfur cluster binding
Adeg_0292	COG5557	Pfam Polysulphide reductase, NrfD
Adeg_0293	COG3344	reverse transcriptase
Adeg_0294	COG0525	valine-tRNA ligase activity
Adeg_0295	COG0285	dihydrofolate synthase activity
Adeg_0297	COG0697	spore germination
Adeg_0300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Adeg_0301	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Adeg_0307	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Adeg_0308	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Adeg_0310	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Adeg_0311	COG0138	bifunctional purine biosynthesis protein purh
Adeg_0312	COG0151	Belongs to the GarS family
Adeg_0314	COG0131	Imidazoleglycerol-phosphate dehydratase
Adeg_0315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Adeg_0316	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Adeg_0317	COG0107	imidazoleglycerol-phosphate synthase activity
Adeg_0323	COG1032	radical SAM domain protein
Adeg_0335	COG1151	hydroxylamine reductase activity
Adeg_0342	COG3573	Dehydrogenase
Adeg_0345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Adeg_0345	COG0646	methionine synthase
Adeg_0347	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Adeg_0348	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Adeg_0349	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Adeg_0350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Adeg_0351	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Adeg_0353	COG1116	anion transmembrane transporter activity
Adeg_0362	COG2252	PERMEase
Adeg_0363	COG3464	Transposase
Adeg_0369	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Adeg_0370	COG0540	Belongs to the ATCase OTCase family
Adeg_0371	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Adeg_0372	COG0505	Belongs to the CarA family
Adeg_0373	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Adeg_0374	COG0543	2 iron, 2 sulfur cluster binding
Adeg_0375	COG0167	dihydroorotate dehydrogenase activity
Adeg_0376	COG0284	orotidine-5'-phosphate decarboxylase activity
Adeg_0377	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Adeg_0378	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Adeg_0378	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Adeg_0379	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Adeg_0380	COG1490	D-aminoacyl-tRNA deacylase activity
Adeg_0381	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Adeg_0384	COG0069	glutamate synthase activity
Adeg_0384	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Adeg_0386	COG0174	glutamine synthetase
Adeg_0387	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Adeg_0393	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Adeg_0394	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Adeg_0395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Adeg_0396	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Adeg_0397	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Adeg_0399	COG1329	Transcriptional regulator
Adeg_0400	COG4956	integral membrane protein (PIN domain superfamily)
Adeg_0401	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Adeg_0401	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Adeg_0402	COG1045	serine acetyltransferase
Adeg_0403	COG0215	cysteine-tRNA ligase activity
Adeg_0404	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Adeg_0405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Adeg_0406	COG3688	RNA-binding protein containing a PIN domain
Adeg_0409	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Adeg_0419	COG0582	viral genome integration into host DNA
Adeg_0420	COG3464	Transposase
Adeg_0421	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Adeg_0422	COG0822	iron-sulfur transferase activity
Adeg_0423	COG1104	cysteine desulfurase activity
Adeg_0425	COG1959	2 iron, 2 sulfur cluster binding
Adeg_0429	COG1543	Belongs to the glycosyl hydrolase 57 family
Adeg_0433	COG0791	NLP P60 protein
Adeg_0438	COG0825	malonyl-CoA metabolic process
Adeg_0439	COG0205	6-phosphofructokinase activity
Adeg_0445	COG0071	Belongs to the small heat shock protein (HSP20) family
Adeg_0447	COG0494	nUDIX hydrolase
Adeg_0449	COG0850	regulation of cytokinetic process
Adeg_0451	COG0297	glycogen (starch) synthase activity
Adeg_0453	COG2719	SpoVR family
Adeg_0454	COG0581	inorganic phosphate transmembrane transporter activity
Adeg_0455	COG0573	inorganic phosphate transmembrane transporter activity
Adeg_0456	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Adeg_0458	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Adeg_0458	COG2199	diguanylate cyclase activity
Adeg_0460	COG3679	Belongs to the UPF0342 family
Adeg_0461	COG2199	diguanylate cyclase activity
Adeg_0464	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Adeg_0466	COG0653	protein targeting
Adeg_0468	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Adeg_0469	COG3959	Transketolase, thiamine diphosphate binding domain
Adeg_0470	COG3958	Transketolase
Adeg_0471	COG2884	Cell division ATP-binding protein ftsE
Adeg_0472	COG2177	Part of the ABC transporter FtsEX involved in
Adeg_0473	COG4942	peptidase
Adeg_0474	COG0793	Belongs to the peptidase S41A family
Adeg_0474	COG3409	Peptidoglycan-binding domain 1 protein
Adeg_0476	COG1376	ErfK ybiS ycfS ynhG family protein
Adeg_0477	COG0860	N-Acetylmuramoyl-L-alanine amidase
Adeg_0478	COG3852	Histidine kinase
Adeg_0479	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Adeg_0481	COG3464	Transposase
Adeg_0487	COG2002	toxin-antitoxin pair type II binding
Adeg_0488	COG0544	peptidyl-prolyl cis-trans isomerase activity
Adeg_0489	COG0740	serine-type endopeptidase activity
Adeg_0490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Adeg_0491	COG0675	Transposase, IS605 OrfB family
Adeg_0492	COG0470	DNA polymerase III
Adeg_0492	COG1067	ATP-dependent peptidase activity
Adeg_0493	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Adeg_0496	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Adeg_0504	COG0438	transferase activity, transferring glycosyl groups
Adeg_0511	COG3464	Transposase
Adeg_0517	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Adeg_0526	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Adeg_0531	COG3852	Histidine kinase
Adeg_0534	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Adeg_0535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Adeg_0536	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Adeg_0540	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Adeg_0541	COG0072	phenylalanine-tRNA ligase activity
Adeg_0541	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Adeg_0542	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Adeg_0545	COG1193	negative regulation of DNA recombination
Adeg_0547	COG0396	ATPase activity
Adeg_0548	COG1372	Participates in initiation and elongation during chromosome replication
Adeg_0548	COG0719	Fe-S assembly protein
Adeg_0550	COG0650	Formate hydrogenlyase subunit 4
Adeg_0551	COG3260	NADH ubiquinone oxidoreductase 20
Adeg_0552	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeg_0553	COG0649	NAD binding
Adeg_0556	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Adeg_0557	COG1131	(ABC) transporter
Adeg_0558	COG0842	Transport permease protein
Adeg_0562	COG0277	FAD linked oxidase domain protein
Adeg_0563	COG2186	Transcriptional regulator
Adeg_0564	COG1620	l-lactate permease
Adeg_0566	COG1139	Iron-sulfur cluster binding protein
Adeg_0567	COG0012	GTP binding
Adeg_0569	COG0861	Integral membrane protein TerC family
Adeg_0570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Adeg_0571	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Adeg_0571	COG0758	DNA mediated transformation
Adeg_0572	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Adeg_0573	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Adeg_0574	COG4974	Belongs to the 'phage' integrase family
Adeg_0576	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Adeg_0577	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Adeg_0578	COG0052	Belongs to the universal ribosomal protein uS2 family
Adeg_0579	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Adeg_0580	COG0528	UMP kinase activity
Adeg_0581	COG0233	cytoplasmic translational termination
Adeg_0584	COG4589	Belongs to the CDS family
Adeg_0585	COG0628	permease
Adeg_0586	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Adeg_0587	COG0750	zinc metalloprotease
Adeg_0588	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Adeg_0589	COG0442	prolyl-tRNA aminoacylation
Adeg_0591	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Adeg_0593	COG0602	queuosine metabolic process
Adeg_0594	COG0302	gtp cyclohydrolase
Adeg_0596	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Adeg_0598	COG2244	polysaccharide biosynthetic process
Adeg_0601	COG0860	N-Acetylmuramoyl-L-alanine amidase
Adeg_0602	COG0481	GTPase activity
Adeg_0603	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Adeg_0604	COG1420	regulation of RNA biosynthetic process
Adeg_0607	COG0443	Heat shock 70 kDa protein
Adeg_0608	COG0484	heat shock protein binding
Adeg_0609	COG2264	protein methyltransferase activity
Adeg_0610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Adeg_0611	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Adeg_0612	COG2359	stage V sporulation protein S
Adeg_0614	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
Adeg_0616	COG0726	polysaccharide deacetylase
Adeg_0620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Adeg_0621	COG0047	phosphoribosylformylglycinamidine synthase activity
Adeg_0622	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Adeg_0625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Adeg_0626	COG1546	Belongs to the CinA family
Adeg_0626	COG1058	Belongs to the CinA family
Adeg_0628	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Adeg_0631	COG0589	response to stress
Adeg_0633	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Adeg_0633	COG1918	ferrous iron import across plasma membrane
Adeg_0635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Adeg_0635	COG1918	ferrous iron import across plasma membrane
Adeg_0640	COG0725	ABC transporter, periplasmic molybdate-binding protein
Adeg_0642	COG3842	ATPase activity
Adeg_0643	COG3464	Transposase
Adeg_0644	COG0745	RESPONSE REGULATOR receiver
Adeg_0645	COG5002	protein histidine kinase activity
Adeg_0645	COG3850	Histidine kinase
Adeg_0647	COG0726	polysaccharide deacetylase
Adeg_0648	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Adeg_0650	COG1877	trehalose-phosphatase activity
Adeg_0655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Adeg_0656	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Adeg_0657	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Adeg_0658	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Adeg_0659	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Adeg_0660	COG0312	modulator of DNA gyrase
Adeg_0661	COG0312	modulator of DNA gyrase
Adeg_0662	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Adeg_0663	COG0006	proline dipeptidase activity
Adeg_0664	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Adeg_0665	COG1980	fructose-bisphosphate aldolase activity
Adeg_0666	COG0671	phosphoesterase, PA-phosphatase related
Adeg_0668	COG1518	maintenance of DNA repeat elements
Adeg_0669	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Adeg_0670	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Adeg_0671	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Adeg_0672	COG1921	L-seryl-tRNASec selenium transferase activity
Adeg_0681	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Adeg_0688	COG0629	single-stranded DNA binding
Adeg_0693	COG0358	DNA primase activity
Adeg_0697	COG1396	sequence-specific DNA binding
Adeg_0712	COG4974	Belongs to the 'phage' integrase family
Adeg_0740	COG2199	diguanylate cyclase activity
Adeg_0740	COG2203	Gaf domain
Adeg_0751	COG2199	diguanylate cyclase activity
Adeg_0751	COG2200	EAL domain
Adeg_0751	COG3287	FIST C domain
Adeg_0763	COG1215	transferase activity, transferring glycosyl groups
Adeg_0776	COG0489	protein tyrosine kinase activity
Adeg_0791	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Adeg_0797	COG2199	diguanylate cyclase activity
Adeg_0797	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Adeg_0831	COG0582	viral genome integration into host DNA
Adeg_0839	COG2052	Domain of unknown function (DUF370)
Adeg_0840	COG0194	GDP metabolic process
Adeg_0845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Adeg_0847	COG1215	transferase activity, transferring glycosyl groups
Adeg_0856	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Adeg_0857	COG0242	peptide deformylase activity
Adeg_0858	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Adeg_0859	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Adeg_0859	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Adeg_0860	COG1686	Belongs to the peptidase S11 family
Adeg_0861	COG1366	Belongs to the anti-sigma-factor antagonist family
Adeg_0862	COG2172	sigma factor antagonist activity
Adeg_0863	COG1191	sigma factor activity
Adeg_0864	COG2861	carbohydrate metabolic process
Adeg_0868	COG0726	polysaccharide deacetylase
Adeg_0869	COG1686	Belongs to the peptidase S11 family
Adeg_0882	COG0460	homoserine dehydrogenase
Adeg_0883	COG0083	homoserine kinase activity
Adeg_0887	COG0519	Catalyzes the synthesis of GMP from XMP
Adeg_0887	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Adeg_0889	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Adeg_0892	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Adeg_0892	COG1328	CTP reductase activity
Adeg_0897	COG1966	Carbon starvation protein
Adeg_0899	COG3275	phosphorelay sensor kinase activity
Adeg_0902	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Adeg_0903	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Adeg_0904	COG0860	N-Acetylmuramoyl-L-alanine amidase
Adeg_0909	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Adeg_0915	COG1337	RAMP superfamily
Adeg_0919	COG0303	'Molybdopterin
Adeg_0920	COG1910	domain protein
Adeg_0921	COG0315	cyclic pyranopterin monophosphate synthase activity
Adeg_0922	COG0521	Mo-molybdopterin cofactor biosynthetic process
Adeg_0923	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Adeg_0924	COG1053	succinate dehydrogenase
Adeg_0926	COG0010	Belongs to the arginase family
Adeg_0927	COG0310	cobalt ion transport
Adeg_0930	COG1122	ATPase activity
Adeg_0931	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Adeg_0934	COG2875	Belongs to the precorrin methyltransferase family
Adeg_0940	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Adeg_0941	COG1030	water channel activity
Adeg_0942	COG0330	HflC and HflK could
Adeg_0944	COG1773	rubredoxin
Adeg_0945	COG2033	superoxide reductase activity
Adeg_0947	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Adeg_0952	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Adeg_0955	COG0416	fatty acid biosynthetic process
Adeg_0956	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Adeg_0957	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Adeg_0958	COG1028	Short-chain dehydrogenase reductase Sdr
Adeg_0959	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Adeg_0960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Adeg_0961	COG0571	ribonuclease III activity
Adeg_0962	COG0552	protein localization to endoplasmic reticulum
Adeg_0963	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Adeg_0964	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Adeg_0965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Adeg_0967	COG0402	S-adenosylhomocysteine deaminase activity
Adeg_0968	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Adeg_0991	COG1268	BioY protein
Adeg_0994	COG1309	transcriptional regulator
Adeg_0996	COG2210	Belongs to the sulfur carrier protein TusA family
Adeg_0999	COG0145	ligase activity
Adeg_1001	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Adeg_1008	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Adeg_1011	COG0745	RESPONSE REGULATOR receiver
Adeg_1012	COG5002	protein histidine kinase activity
Adeg_1013	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Adeg_1015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Adeg_1016	COG1799	cell septum assembly
Adeg_1017	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Adeg_1018	COG0762	integral membrane protein
Adeg_1019	COG1872	DUF167
Adeg_1020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Adeg_1021	COG0741	lytic transglycosylase activity
Adeg_1022	COG0237	dephospho-CoA kinase activity
Adeg_1023	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Adeg_1027	COG5002	protein histidine kinase activity
Adeg_1028	COG0745	RESPONSE REGULATOR receiver
Adeg_1030	COG0586	Pfam SNARE associated Golgi protein
Adeg_1032	COG0438	transferase activity, transferring glycosyl groups
Adeg_1040	COG2197	response regulator
Adeg_1070	COG3344	reverse transcriptase
Adeg_1071	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Adeg_1073	COG2766	serine protein kinase
Adeg_1074	COG2718	Belongs to the UPF0229 family
Adeg_1082	COG0501	Belongs to the peptidase M48B family
Adeg_1089	COG0489	protein tyrosine kinase activity
Adeg_1090	COG2894	cell division
Adeg_1094	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Adeg_1095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Adeg_1096	COG0154	amidase activity
Adeg_1097	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Adeg_1099	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Adeg_1100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Adeg_1101	COG0066	3-isopropylmalate dehydratase activity
Adeg_1102	COG0473	3-isopropylmalate dehydrogenase activity
Adeg_1103	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Adeg_1104	COG1116	anion transmembrane transporter activity
Adeg_1106	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Adeg_1107	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Adeg_1108	COG1181	Belongs to the D-alanine--D-alanine ligase family
Adeg_1109	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Adeg_1121	COG1695	Transcriptional regulator
Adeg_1122	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Adeg_1126	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Adeg_1128	COG0457	Tetratricopeptide repeat
Adeg_1128	COG0463	Glycosyl transferase, family 2
Adeg_1129	COG1215	transferase activity, transferring glycosyl groups
Adeg_1131	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Adeg_1136	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Adeg_1137	COG0517	IMP dehydrogenase activity
Adeg_1137	COG0516	GMP reductase activity
Adeg_1139	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Adeg_1139	COG1918	ferrous iron import across plasma membrane
Adeg_1146	COG0539	negative regulation of cytoplasmic translation
Adeg_1146	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Adeg_1147	COG0204	Acyl-transferase
Adeg_1148	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Adeg_1149	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Adeg_1150	COG0287	Prephenate dehydrogenase
Adeg_1153	COG0077	Prephenate dehydratase
Adeg_1154	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Adeg_1155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Adeg_1156	COG0159	tryptophan synthase activity
Adeg_1157	COG0133	tryptophan synthase activity
Adeg_1158	COG0135	phosphoribosylanthranilate isomerase activity
Adeg_1159	COG0134	indole-3-glycerol-phosphate synthase activity
Adeg_1160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Adeg_1161	COG0512	Glutamine amidotransferase of anthranilate synthase
Adeg_1163	COG3464	Transposase
Adeg_1170	COG0482	sulfurtransferase activity
Adeg_1171	COG1683	Conserved Protein
Adeg_1188	COG2855	membrane
Adeg_1193	COG1120	ATPase activity
Adeg_1194	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Adeg_1198	COG5557	Pfam Polysulphide reductase, NrfD
Adeg_1199	COG0437	4 iron, 4 sulfur cluster binding
Adeg_1199	COG3064	Membrane
Adeg_1204	COG1573	uracil-dna glycosylase
Adeg_1205	COG1122	ATPase activity
Adeg_1207	COG0475	glutathione-regulated potassium exporter activity
Adeg_1209	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Adeg_1211	COG0432	Pfam Uncharacterised protein family UPF0047
Adeg_1213	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Adeg_1214	COG1121	(ABC) transporter
Adeg_1215	COG0803	Belongs to the bacterial solute-binding protein 9 family
Adeg_1216	COG0735	belongs to the Fur family
Adeg_1220	COG0084	hydrolase, TatD family'
Adeg_1222	COG2146	nitrite reductase [NAD(P)H] activity
Adeg_1222	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Adeg_1223	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Adeg_1224	COG1160	GTP binding
Adeg_1225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Adeg_1228	COG3290	protein histidine kinase activity
Adeg_1228	COG0840	transmembrane signaling receptor activity
Adeg_1229	COG0805	protein transport
Adeg_1230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Adeg_1233	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Adeg_1234	COG0205	6-phosphofructokinase activity
Adeg_1237	COG0563	adenylate kinase activity
Adeg_1240	COG1027	Aspartate ammonia-lyase
Adeg_1243	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Adeg_1244	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Adeg_1245	COG0697	spore germination
Adeg_1247	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Adeg_1251	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeg_1253	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Adeg_1256	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Adeg_1257	COG0113	porphobilinogen synthase activity
Adeg_1259	COG0181	hydroxymethylbilane synthase activity
Adeg_1260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Adeg_1261	COG1648	precorrin-2 dehydrogenase activity
Adeg_1261	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Adeg_1263	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Adeg_1266	COG0740	serine-type endopeptidase activity
Adeg_1267	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Adeg_1267	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Adeg_1269	COG2848	UPF0210 protein
Adeg_1270	COG3830	Belongs to the UPF0237 family
Adeg_1271	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Adeg_1272	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Adeg_1274	COG1862	Preprotein translocase
Adeg_1275	COG0343	queuine tRNA-ribosyltransferase activity
Adeg_1276	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Adeg_1278	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Adeg_1279	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Adeg_1282	COG1302	Protein conserved in bacteria
Adeg_1283	COG0439	Biotin carboxylase
Adeg_1284	COG0511	ligase activity, forming carbon-carbon bonds
Adeg_1284	COG5016	pyruvate
Adeg_1287	COG0438	transferase activity, transferring glycosyl groups
Adeg_1292	COG1187	pseudouridine synthase activity
Adeg_1293	COG0700	Nucleoside recognition
Adeg_1294	COG0741	lytic transglycosylase activity
Adeg_1296	COG2715	membrane protein required for spore maturation
Adeg_1297	COG3874	Sporulation protein YtfJ
Adeg_1300	COG0180	Tryptophanyl-tRNA synthetase
Adeg_1301	COG1994	Peptidase M50
Adeg_1303	COG0019	diaminopimelate decarboxylase activity
Adeg_1306	COG3706	GGDEF domain
Adeg_1308	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Adeg_1309	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Adeg_1310	COG1162	GTPase activity
Adeg_1311	COG2815	serine threonine protein kinase
Adeg_1311	COG0515	serine threonine protein kinase
Adeg_1312	COG0631	protein serine/threonine phosphatase activity
Adeg_1313	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Adeg_1319	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Adeg_1326	COG1694	Mazg nucleotide pyrophosphohydrolase
Adeg_1329	COG2871	sodium ion transport
Adeg_1334	COG2048	Heterodisulfide reductase, subunit B
Adeg_1336	COG0582	viral genome integration into host DNA
Adeg_1345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Adeg_1370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Adeg_1379	COG0450	alkyl hydroperoxide reductase
Adeg_1381	COG0436	Aminotransferase
Adeg_1382	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Adeg_1389	COG0463	Glycosyl transferase, family 2
Adeg_1392	COG0745	RESPONSE REGULATOR receiver
Adeg_1393	COG0750	zinc metalloprotease
Adeg_1394	COG0497	DNA recombination
Adeg_1395	COG1438	arginine binding
Adeg_1396	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Adeg_1397	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Adeg_1398	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Adeg_1401	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Adeg_1402	COG1342	Belongs to the UPF0251 family
Adeg_1405	COG0675	Transposase, IS605 OrfB family
Adeg_1406	COG0792	nuclease activity
Adeg_1407	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Adeg_1409	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Adeg_1410	COG0681	Belongs to the peptidase S26 family
Adeg_1411	COG0335	large ribosomal subunit rRNA binding
Adeg_1412	COG0336	Belongs to the RNA methyltransferase TrmD family
Adeg_1413	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Adeg_1416	COG0228	four-way junction DNA binding
Adeg_1417	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Adeg_1418	COG1110	DNA topoisomerase II activity
Adeg_1425	COG0446	pyridine nucleotide-disulphide oxidoreductase
Adeg_1429	COG2146	nitrite reductase [NAD(P)H] activity
Adeg_1429	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Adeg_1431	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Adeg_1434	COG0768	penicillin binding
Adeg_1435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Adeg_1436	COG2720	vancomycin resistance protein
Adeg_1437	COG3906	Belongs to the UPF0473 family
Adeg_1438	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Adeg_1439	COG4472	Bacterial protein of unknown function (DUF965)
Adeg_1440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Adeg_1445	COG0653	protein targeting
Adeg_1447	COG0038	chloride channel
Adeg_1449	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Adeg_1450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Adeg_1452	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Adeg_1453	COG2226	methyltransferase
Adeg_1455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Adeg_1459	COG0589	response to stress
Adeg_1464	COG0668	transmembrane transport
Adeg_1466	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Adeg_1467	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Adeg_1473	COG2359	stage V sporulation protein S
Adeg_1474	COG1692	metallophosphoesterase
Adeg_1475	COG1418	mRNA catabolic process
Adeg_1476	COG3706	GGDEF domain
Adeg_1477	COG0438	transferase activity, transferring glycosyl groups
Adeg_1481	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Adeg_1482	COG2205	protein histidine kinase activity
Adeg_1483	COG2333	competence protein COMEC
Adeg_1483	COG0658	competence protein
Adeg_1485	COG2323	membrane
Adeg_1493	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Adeg_1494	COG0101	tRNA pseudouridine synthase activity
Adeg_1495	COG0203	ribosomal protein L17
Adeg_1496	COG0202	RNA polymerase activity
Adeg_1497	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Adeg_1498	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Adeg_1499	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Adeg_1501	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Adeg_1503	COG0024	Methionine aminopeptidase
Adeg_1504	COG0201	protein transport
Adeg_1505	COG0200	Binds to the 23S rRNA
Adeg_1506	COG1841	ribosomal large subunit assembly
Adeg_1507	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Adeg_1508	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Adeg_1509	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Adeg_1510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Adeg_1511	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Adeg_1512	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Adeg_1513	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Adeg_1514	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Adeg_1515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Adeg_1516	COG0255	Belongs to the universal ribosomal protein uL29 family
Adeg_1517	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Adeg_1518	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Adeg_1519	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Adeg_1520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Adeg_1521	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Adeg_1522	COG0089	rRNA binding
Adeg_1523	COG0088	Forms part of the polypeptide exit tunnel
Adeg_1524	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Adeg_1525	COG0051	transcription antitermination factor activity, RNA binding
Adeg_1526	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Adeg_1527	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Adeg_1528	COG0049	tRNA binding
Adeg_1529	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Adeg_1531	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Adeg_1532	COG0085	RNA polymerase activity
Adeg_1533	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Adeg_1534	COG2894	cell division
Adeg_1535	COG0850	regulation of cytokinetic process
Adeg_1536	COG0735	belongs to the Fur family
Adeg_1540	COG1077	Cell shape determining protein MreB Mrl
Adeg_1541	COG2003	Belongs to the UPF0758 family
Adeg_1542	COG0424	maF-like protein
Adeg_1547	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Adeg_1549	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Adeg_1550	COG1873	PFAM PRC-barrel domain
Adeg_1552	COG1191	sigma factor activity
Adeg_1553	COG1191	sigma factor activity
Adeg_1555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Adeg_1556	COG3856	small basic protein
Adeg_1561	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Adeg_1562	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Adeg_1563	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Adeg_1564	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Adeg_1565	COG0772	Belongs to the SEDS family
Adeg_1566	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Adeg_1567	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Adeg_1568	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Adeg_1569	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Adeg_1570	COG0768	penicillin binding
Adeg_1572	COG0275	rRNA processing
Adeg_1573	COG2001	Belongs to the MraZ family
Adeg_1576	COG0268	Binds directly to 16S ribosomal RNA
Adeg_1578	COG0011	TIGRFAM Protein of
Adeg_1581	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Adeg_1582	COG0039	L-malate dehydrogenase activity
Adeg_1584	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Adeg_1585	COG0589	response to stress
Adeg_1590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Adeg_1593	COG0410	ABC transporter
Adeg_1594	COG0683	leucine binding
Adeg_1596	COG0559	Belongs to the binding-protein-dependent transport system permease family
Adeg_1597	COG1022	Amp-dependent synthetase and ligase
Adeg_1600	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Adeg_1602	COG2814	Major facilitator Superfamily
Adeg_1603	COG1809	phosphosulfolactate synthase activity
Adeg_1604	COG0564	pseudouridine synthase activity
Adeg_1605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Adeg_1609	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Adeg_1610	COG2226	methyltransferase
Adeg_1611	COG0772	Belongs to the SEDS family
Adeg_1613	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Adeg_1614	COG0148	phosphopyruvate hydratase activity
Adeg_1615	COG0149	triose-phosphate isomerase activity
Adeg_1616	COG0126	phosphoglycerate kinase activity
Adeg_1619	COG1481	regulation of sporulation
Adeg_1620	COG0726	polysaccharide deacetylase
Adeg_1621	COG1660	Displays ATPase and GTPase activities
Adeg_1622	COG0166	Belongs to the GPI family
Adeg_1623	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Adeg_1624	COG5002	protein histidine kinase activity
Adeg_1624	COG5001	Diguanylate cyclase
Adeg_1626	COG0791	NLP P60 protein
Adeg_1626	COG1388	LysM domain
Adeg_1627	COG2385	sporulation resulting in formation of a cellular spore
Adeg_1627	COG2247	cell wall binding repeat
Adeg_1629	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Adeg_1630	COG2255	four-way junction helicase activity
Adeg_1631	COG0632	four-way junction helicase activity
Adeg_1632	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Adeg_1634	COG0217	transcriptional regulatory protein
Adeg_1635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Adeg_1638	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Adeg_1644	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Adeg_1645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Adeg_1647	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Adeg_1648	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Adeg_1649	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Adeg_1652	COG0756	dUTP diphosphatase activity
Adeg_1653	COG0612	Peptidase, M16
Adeg_1654	COG0860	N-Acetylmuramoyl-L-alanine amidase
Adeg_1655	COG0726	polysaccharide deacetylase
Adeg_1656	COG1185	polyribonucleotide nucleotidyltransferase activity
Adeg_1657	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Adeg_1658	COG0196	riboflavin kinase activity
Adeg_1659	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Adeg_1661	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Adeg_1662	COG3064	Membrane
Adeg_1662	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Adeg_1664	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Adeg_1665	COG0195	Participates in both transcription termination and antitermination
Adeg_1666	COG0779	Required for maturation of 30S ribosomal subunits
Adeg_1667	COG3118	belongs to the thioredoxin family
Adeg_1668	COG1396	sequence-specific DNA binding
Adeg_1669	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Adeg_1670	COG0456	acetyltransferase
Adeg_1672	COG1283	sodium-dependent phosphate transmembrane transporter activity
Adeg_1673	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Adeg_1674	COG0124	histidyl-tRNA synthetase
Adeg_1675	COG1215	transferase activity, transferring glycosyl groups
Adeg_1676	COG1090	epimerase
Adeg_1678	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Adeg_1686	COG3854	ATPases associated with a variety of cellular activities
Adeg_1690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Adeg_1695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Adeg_1696	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Adeg_1697	COG1461	Dihydroxyacetone kinase
Adeg_1698	COG1307	EDD domain protein, DegV family
Adeg_1699	COG0857	belongs to the CobB CobQ family
Adeg_1700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Adeg_1700	COG0045	succinate-CoA ligase (ADP-forming) activity
Adeg_1700	COG1042	CoA-binding domain protein
Adeg_1701	COG3773	Cell wall hydrolase
Adeg_1703	COG3935	DnaD domain protein
Adeg_1709	COG0037	tRNA processing
Adeg_1712	COG2046	Belongs to the sulfate adenylyltransferase family
Adeg_1715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Adeg_1725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Adeg_1726	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Adeg_1727	COG0358	DNA primase activity
Adeg_1728	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Adeg_1729	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Adeg_1730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Adeg_1730	COG0574	Belongs to the PEP-utilizing enzyme family
Adeg_1731	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Adeg_1732	COG0517	IMP dehydrogenase activity
Adeg_1733	COG0751	glycine-tRNA ligase activity
Adeg_1734	COG0752	glycyl-tRNA synthetase alpha subunit
Adeg_1735	COG1381	Involved in DNA repair and RecF pathway recombination
Adeg_1743	COG2414	aldehyde ferredoxin oxidoreductase
Adeg_1744	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Adeg_1747	COG1937	Protein conserved in bacteria
Adeg_1755	COG0791	NLP P60 protein
Adeg_1755	COG1388	LysM domain
Adeg_1756	COG0617	tRNA 3'-terminal CCA addition
Adeg_1758	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Adeg_1759	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Adeg_1759	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Adeg_1760	COG0736	holo-[acyl-carrier-protein] synthase activity
Adeg_1761	COG3279	Response regulator of the LytR AlgR family
Adeg_1762	COG3275	phosphorelay sensor kinase activity
Adeg_1763	COG2217	Heavy metal translocating P-type atpase
Adeg_1766	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Adeg_1767	COG1468	defense response to virus
Adeg_1767	COG1518	maintenance of DNA repeat elements
Adeg_1778	COG2378	regulation of single-species biofilm formation
Adeg_1780	COG3546	catalase activity
Adeg_1784	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Adeg_1792	COG1796	DNA polymerase
Adeg_1792	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Adeg_1795	COG2814	Major facilitator Superfamily
Adeg_1796	COG1254	Belongs to the acylphosphatase family
Adeg_1798	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Adeg_1804	COG0495	leucyl-tRNA aminoacylation
Adeg_1809	COG2198	Histidine kinase
Adeg_1809	COG0643	Histidine kinase
Adeg_1810	COG1366	Belongs to the anti-sigma-factor antagonist family
Adeg_1811	COG1366	Belongs to the anti-sigma-factor antagonist family
Adeg_1818	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Adeg_1821	COG1940	carbohydrate kinase activity
Adeg_1822	COG0561	phosphatase activity
Adeg_1823	COG0322	excinuclease ABC activity
Adeg_1824	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Adeg_1825	COG0556	nucleotide-excision repair
Adeg_1827	COG0165	Argininosuccinate lyase
Adeg_1828	COG0137	argininosuccinate synthase activity
Adeg_1829	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Adeg_1830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Adeg_1831	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Adeg_1832	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Adeg_1833	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Adeg_1835	COG0156	8-amino-7-oxononanoate synthase activity
Adeg_1837	COG3464	Transposase
Adeg_1845	COG1968	undecaprenyl-diphosphatase activity
Adeg_1846	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Adeg_1850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Adeg_1852	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Adeg_1853	COG0492	ferredoxin-NADP+ reductase activity
Adeg_1854	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Adeg_1855	COG1414	Transcriptional regulator
Adeg_1858	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Adeg_1859	COG1980	fructose-bisphosphate aldolase activity
Adeg_1860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Adeg_1861	COG3959	Transketolase, thiamine diphosphate binding domain
Adeg_1862	COG0572	uridine kinase
Adeg_1863	COG1850	ribulose-bisphosphate carboxylase activity
Adeg_1864	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Adeg_1868	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Adeg_1873	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Adeg_1874	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Adeg_1875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Adeg_1876	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Adeg_1877	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Adeg_1879	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Adeg_1880	COG0535	radical SAM domain protein
Adeg_1881	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Adeg_1883	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Adeg_1884	COG0247	lactate metabolic process
Adeg_1885	COG0446	pyridine nucleotide-disulphide oxidoreductase
Adeg_1887	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Adeg_1888	COG0347	Belongs to the P(II) protein family
Adeg_1889	COG0004	ammonium transporteR
Adeg_1892	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Adeg_1893	COG3005	denitrification pathway
Adeg_1894	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Adeg_1895	COG1333	cytochrome c biogenesis protein
Adeg_1897	COG0745	RESPONSE REGULATOR receiver
Adeg_1902	COG1140	nitrate reductase beta subunit
Adeg_1903	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Adeg_1904	COG0348	domain, Protein
Adeg_1905	COG1151	hydroxylamine reductase activity
Adeg_1906	COG1959	2 iron, 2 sulfur cluster binding
Adeg_1909	COG1309	transcriptional regulator
Adeg_1912	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Adeg_1915	COG3344	reverse transcriptase
Adeg_1916	COG0500	methyltransferase
Adeg_1917	COG5416	Lipopolysaccharide assembly protein A domain
Adeg_1918	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Adeg_1919	COG0492	ferredoxin-NADP+ reductase activity
Adeg_1920	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Adeg_1921	COG1923	regulation of RNA biosynthetic process
Adeg_1922	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Adeg_1923	COG2521	methyltransferase
Adeg_1923	COG2136	Putative SAM-dependent methyltransferase
Adeg_1924	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Adeg_1925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Adeg_1926	COG0222	ribosome binding
Adeg_1927	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Adeg_1928	COG0081	regulation of translation
Adeg_1929	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Adeg_1930	COG0250	Participates in transcription elongation, termination and antitermination
Adeg_1932	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Adeg_1934	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Adeg_1937	COG0798	PFAM Bile acid sodium symporter
Adeg_1940	COG0640	Transcriptional regulator
Adeg_1941	COG0537	adenosine 5'-monophosphoramidase activity
Adeg_1942	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Adeg_1943	COG1426	Protein conserved in bacteria
Adeg_1944	COG1674	ftsk spoiiie
Adeg_1948	COG0542	response to heat
Adeg_1949	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Adeg_1950	COG3880	PFAM UvrB UvrC protein
Adeg_1952	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Adeg_1953	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Adeg_1955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Adeg_1959	COG0310	cobalt ion transport
Adeg_1960	COG0310	cobalt ion transport
Adeg_1961	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Adeg_1962	COG0473	3-isopropylmalate dehydrogenase activity
Adeg_1963	COG5278	phosphoserine phosphatase activity
Adeg_1963	COG0840	transmembrane signaling receptor activity
Adeg_1966	COG0728	peptidoglycan biosynthetic process
Adeg_1967	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Adeg_1968	COG2323	membrane
Adeg_1969	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Adeg_1970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Adeg_1971	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Adeg_1972	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Adeg_1973	COG1316	TRANSCRIPTIONal
Adeg_1977	COG1924	4 iron, 4 sulfur cluster binding
Adeg_1978	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Adeg_1979	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Adeg_1980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Adeg_1980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Adeg_1982	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Adeg_1982	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Adeg_1983	COG0577	efflux transmembrane transporter activity
Adeg_1984	COG1136	(ABC) transporter
Adeg_1985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeg_1989	COG0640	Transcriptional regulator
Adeg_1993	COG3464	Transposase
Adeg_2006	COG0309	Hydrogenase expression formation protein (HypE)
Adeg_2008	COG0298	carbon dioxide binding
Adeg_2009	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Adeg_2010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Adeg_2011	COG0375	protein maturation
Adeg_2013	COG3259	Nickel-dependent hydrogenase
Adeg_2017	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Adeg_2017	COG1776	CheC inhibitor of MCP methylation
Adeg_2018	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Adeg_2019	COG2201	protein-glutamate methylesterase activity
Adeg_2020	COG1776	CheC inhibitor of MCP methylation
Adeg_2021	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Adeg_2022	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Adeg_2023	COG4786	Flagellar basal body rod
Adeg_2025	COG1191	sigma factor activity
Adeg_2027	COG0455	bacterial-type flagellum organization
Adeg_2028	COG1419	protein localization to endoplasmic reticulum
Adeg_2029	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Adeg_2030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Adeg_2031	COG1684	flagellar biosynthetic protein fliR
Adeg_2032	COG1987	bacterial-type flagellum assembly
Adeg_2033	COG1338	Plays a role in the flagellum-specific transport system
Adeg_2035	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Adeg_2035	COG1776	CheC inhibitor of MCP methylation
Adeg_2037	COG4786	Flagellar basal body rod
Adeg_2041	COG1157	protein secretion by the type III secretion system
Adeg_2043	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Adeg_2044	COG1766	The M ring may be actively involved in energy transduction
Adeg_2045	COG1677	Flagellar hook-basal body complex protein FliE
Adeg_2047	COG1815	bacterial-type flagellum-dependent cell motility
Adeg_2049	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Adeg_2053	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Adeg_2054	COG0765	amino acid transport
Adeg_2055	COG1126	abc transporter atp-binding protein
Adeg_2057	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Adeg_2058	COG0105	UTP biosynthetic process
Adeg_2059	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Adeg_2060	COG0037	tRNA processing
Adeg_2063	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Adeg_2070	COG3956	TIGRFAM MazG family protein
Adeg_2071	COG2002	toxin-antitoxin pair type II binding
Adeg_2072	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Adeg_2073	COG0193	aminoacyl-tRNA hydrolase activity
Adeg_2074	COG1333	cytochrome c biogenesis protein
Adeg_2075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Adeg_2078	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Adeg_2079	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Adeg_2081	COG2391	methyltransferase activity
Adeg_2082	COG0425	Belongs to the sulfur carrier protein TusA family
Adeg_2093	COG2221	Nitrite and sulphite reductase 4Fe-4S
Adeg_2094	COG2221	Nitrite and sulphite reductase 4Fe-4S
Adeg_2095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Adeg_2096	COG1802	Transcriptional regulator
Adeg_2097	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Adeg_2110	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Adeg_2111	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Adeg_2112	COG3583	domain protein
Adeg_2112	COG3584	3D domain protein
Adeg_2113	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Adeg_2114	COG0084	hydrolase, TatD family'
Adeg_2115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Adeg_2115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Adeg_2116	COG2002	toxin-antitoxin pair type II binding
Adeg_2117	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Adeg_2118	COG1774	PSP1 C-terminal conserved region
Adeg_2120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Adeg_2121	COG1982	Orn Lys Arg decarboxylase major
Adeg_2125	COG0674	pyruvate-flavodoxin oxidoreductase activity
Adeg_2125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Adeg_2128	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Adeg_2129	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Adeg_2130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Adeg_2131	COG0590	tRNA wobble adenosine to inosine editing
Adeg_2132	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Adeg_2133	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Adeg_2134	COG0305	Participates in initiation and elongation during chromosome replication
Adeg_2135	COG0359	binds to the 23S rRNA
Adeg_2136	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Adeg_2137	COG0629	single-stranded DNA binding
Adeg_2138	COG0360	Binds together with S18 to 16S ribosomal RNA
Adeg_2145	COG1475	DNA binding
Adeg_2146	COG1192	Involved in chromosome partitioning
Adeg_2147	COG0357	Ribosomal RNA small subunit methyltransferase G
Adeg_2148	COG1847	R3H domain protein
Adeg_2149	COG0706	membrane insertase activity
Adeg_2150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Adeg_2151	COG0594	ribonuclease P activity
Adeg_2152	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Adeg_2179	COG4974	Belongs to the 'phage' integrase family