locus-tag class description AXY_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AXY_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AXY_00030 ENOG410848D S4 domain protein YaaA AXY_00040 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AXY_00060 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXY_00070 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXY_00080 ENOG4105DHT Metal Dependent Phosphohydrolase AXY_00090 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AXY_00110 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AXY_00120 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AXY_00130 ENOG4107QM2 Aldo Keto reductase AXY_00160 ENOG4105E1K spore germination protein AXY_00170 ENOG4105VRS hydrolase family 18 AXY_00180 ENOG4108Z6B deaminase AXY_00190 ENOG4105C6E dna polymerase iii AXY_00200 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AXY_00210 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AXY_00250 ENOG4108JQ7 (ABC) transporter AXY_00260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AXY_00300 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AXY_00310 ENOG4105X0R protein from nitrogen regulatory protein P-II AXY_00320 ENOG4105XVJ Protein of unknown function (DUF327) AXY_00330 ENOG4105FA2 dna polymerase iii AXY_00340 ENOG4105MA4 psp1 domain protein AXY_00350 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) AXY_00360 ENOG41060K3 Methyltransferase AXY_00370 ENOG4105VC4 domain protein AXY_00380 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AXY_00390 ENOG4105KRN Transcriptional regulator, abrb family AXY_00400 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AXY_00410 ENOG4105F8V Hydrolase, tatD family AXY_00420 ENOG41069ER domain protein AXY_00440 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AXY_00450 ENOG4105EKQ RNA-directed DNA polymerase AXY_00490 ENOG4105XFA sporulation peptidase YabG AXY_00500 ENOG4105W42 Veg protein AXY_00510 ENOG4105DFT pur operon repressor AXY_00520 ENOG4105K4W Could be involved in septation (By similarity) AXY_00530 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AXY_00540 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AXY_00550 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AXY_00560 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AXY_00580 ENOG4108JA2 transcriptioN-repair coupling factor AXY_00590 ENOG4108M14 stage v sporulation protein t AXY_00610 ENOG4108IY2 MazG family AXY_00620 ENOG41082I2 s4 domain protein AXY_00630 ENOG4105VYY sporulation protein yabp AXY_00660 ENOG41060GV RNA binding s1 domain protein AXY_00740 ENOG4108JJB ABC transporter AXY_00750 ENOG4108JJB ABC transporter AXY_00800 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AXY_00810 ENOG4108UGV hypoxanthine phosphoribosyltransferase AXY_00820 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AXY_00830 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AXY_00840 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AXY_00850 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AXY_00860 ENOG4105C6T cysteine synthase AXY_00870 ENOG4105EEI dihydropteroate synthase AXY_00880 ENOG4105KRF dihydroneopterin aldolase AXY_00890 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AXY_00910 ENOG4105CRK lysyL-tRNA synthetase AXY_00920 ENOG4105EPR degv family AXY_00930 ENOG4105KT7 mgtC SapB transporter AXY_00950 ENOG4108Z0C Uvrb UvrC protein AXY_00960 ENOG41066A3 ATP guanido phosphotransferase AXY_00970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AXY_00980 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AXY_00990 ENOG4105CTP PilT protein domain protein AXY_01000 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AXY_01010 ENOG4105D7W serine acetyltransferase AXY_01020 ENOG4105C8N cysteinyl-tRNA synthetase AXY_01030 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) AXY_01040 ENOG4105C2N RNA methyltransferase TrmH family group 3 AXY_01050 ENOG4105M0M Tetracycline resistance protein AXY_01060 ENOG4105QIV RNA polymerase AXY_01070 ENOG4107FTN 50S ribosomal protein L33 AXY_01080 ENOG410683Z Preprotein translocase SecE subunit AXY_01090 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AXY_01100 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AXY_01110 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AXY_01120 ENOG4108VZM 50s ribosomal protein L10 AXY_01130 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AXY_01140 ENOG4107Y49 methyltransferase AXY_01150 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AXY_01160 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AXY_01170 ENOG4105XPM ribosomal protein AXY_01180 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AXY_01190 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AXY_01200 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AXY_01210 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AXY_01220 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AXY_01230 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AXY_01240 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AXY_01250 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AXY_01260 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AXY_01270 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AXY_01280 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AXY_01290 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AXY_01300 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AXY_01310 ENOG41082SA 50s ribosomal protein l29 AXY_01320 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AXY_01330 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AXY_01340 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AXY_01350 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AXY_01360 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AXY_01370 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AXY_01380 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AXY_01390 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AXY_01400 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AXY_01410 ENOG4105VPB 50S ribosomal protein L30 AXY_01430 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AXY_01440 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AXY_01460 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AXY_01480 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AXY_01490 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AXY_01500 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AXY_01510 ENOG4108ZT0 50S ribosomal protein l17 AXY_01520 ENOG4108JJB ABC transporter AXY_01530 ENOG4108JJB ABC transporter AXY_01540 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AXY_01550 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AXY_01560 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AXY_01570 ENOG4108UJD 30S ribosomal protein S9 AXY_01590 ENOG4105EN2 IstB domain-containing protein ATP-binding protein AXY_01670 ENOG4107WD8 ABC transporter, permease AXY_01690 ENOG4105D9P serine threonine protein kinase AXY_01720 ENOG4107ZXU DSBA oxidoreductase AXY_01740 ENOG4105WEF catalase AXY_01750 ENOG4105D58 Diguanylate phosphodiesterase AXY_01770 ENOG4105D1F ATP-binding protein AXY_01790 ENOG4108NMV polysaccharide deacetylase AXY_01810 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXY_01910 ENOG4105WXW Antirepressor AXY_01940 ENOG4108UUM single-stranded DNA-binding protein AXY_02120 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AXY_02310 ENOG4105DR5 peptidase AXY_02340 ENOG4107TVC Glycosyl transferase, family 2 AXY_02360 ENOG4106WTF Glycosyl transferase, family 2 AXY_02380 ENOG4105C8B TIGR00159 family AXY_02390 ENOG4107U5W ybbr family AXY_02400 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AXY_02410 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein AXY_02450 ENOG4105FH5 Membrane AXY_02460 ENOG4105EN6 Membrane AXY_02490 ENOG4107TXC Transcriptional regulator AXY_02500 ENOG4107TXC Transcriptional regulator AXY_02520 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AXY_02560 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AXY_02570 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AXY_02590 ENOG4105KG3 cytidine deaminase AXY_02600 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AXY_02620 ENOG4107VQW regulatoR AXY_02630 ENOG4105DSG hydrolase family 43 AXY_02640 ENOG4105EK5 Glycoside hydrolase family 8 AXY_02670 ENOG4105MU9 integral membrane protein AXY_02680 ENOG4105C2F Histidine kinase AXY_02710 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AXY_02730 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AXY_02740 ENOG4105DMW Dehydrogenase reductase AXY_02750 ENOG4108UHU Aldolase AXY_02770 ENOG4105D2H Uronic isomerase AXY_02780 ENOG4105C93 Xylose Isomerase AXY_02790 ENOG4105CMG Carbohydrate kinase AXY_02810 ENOG4105DWF phosphomethylpyrimidine kinase AXY_02820 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AXY_02850 ENOG4105C26 Dehydrogenase AXY_02880 ENOG4105BZU Histidine kinase AXY_02890 ENOG4105WH1 Two component transcriptional regulator luxr family AXY_02900 ENOG4105CJ1 ABC, transporter AXY_02930 ENOG4105DKQ ROK family AXY_02940 ENOG4105EJQ L-serine dehydratase AXY_02950 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AXY_02960 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AXY_02980 ENOG4105C7J ABC transporter, permease AXY_02990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AXY_03000 ENOG4105DKW ABC transporter AXY_03010 ENOG4108EKI Dehydrogenase AXY_03030 ENOG4105C6N Formate acetyltransferase AXY_03040 ENOG4105F1A Pyruvate formate-lyase AXY_03050 ENOG4108ZHJ Organic hydroperoxide resistance protein AXY_03070 ENOG4105C3F Signal peptidase i AXY_03090 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AXY_03100 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AXY_03120 ENOG4105CPF Cell wall formation (By similarity) AXY_03140 ENOG4105DBV ornithine carbamoyltransferase AXY_03150 ENOG4105D4A Cell wall formation (By similarity) AXY_03160 ENOG4105C72 UPF0176 protein AXY_03190 ENOG4105C0H protease AXY_03210 ENOG4105BZU Histidine kinase AXY_03220 ENOG4105CI3 gtp-binding protein typa AXY_03230 ENOG4105CVA phosphate AXY_03240 ENOG4105C8U phosphate abc transporter AXY_03250 ENOG4105E2Z phosphate ABC transporter (Permease AXY_03260 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AXY_03270 ENOG4107R34 abc transporter permease protein AXY_03280 ENOG4105C19 ABC transporter AXY_03290 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AXY_03340 ENOG41090MY MarR family Transcriptional regulator AXY_03380 ENOG4108S8M degv family AXY_03390 ENOG4105C1J atp-dependent rna helicase AXY_03420 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AXY_03430 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AXY_03440 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AXY_03470 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AXY_03480 ENOG4107MMM Anti-sigma-factor antagonist AXY_03490 ENOG4105FUA antagonist AXY_03500 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase AXY_03510 ENOG4107SGM protein serine threonine phosphatase AXY_03520 ENOG4105WN5 stage II sporulation protein AXY_03530 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AXY_03550 ENOG41064BQ Phosphatase AXY_03570 ENOG4105C5B carbamate kinase AXY_03580 ENOG410906U SprT-like AXY_03590 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AXY_03600 ENOG4105K8N protein family UPF0079, ATPase AXY_03610 ENOG41072GX Peptidase M22 Glycoprotease AXY_03620 ENOG410801F ribosomal-protein-alanine acetyltransferase AXY_03630 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AXY_03640 ENOG4105C5H ABC transporter AXY_03650 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AXY_03670 ENOG4108TYN CAAX amino terminal protease family protein AXY_03680 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AXY_03690 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AXY_03740 ENOG4105BZU Histidine kinase AXY_03750 ENOG4107RVV histidinol phosphate phosphatase, hisj family AXY_03780 ENOG4105CPC Aldo Keto reductase AXY_03830 ENOG4107RJ5 oxidoreductase AXY_03850 ENOG4105CK5 oxidoreductase AXY_03860 ENOG4107QP6 Xylose isomerase domain protein TIM barrel AXY_03870 ENOG4105BZU Histidine kinase AXY_03890 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AXY_03930 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AXY_03940 ENOG4108RE9 Phosphodiesterase AXY_03960 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AXY_03970 ENOG4105CHR reductase AXY_03980 ENOG4105I3N Conserved Protein AXY_04040 ENOG4105DM4 PTS System AXY_04050 ENOG4105DE4 1-phosphofructokinase AXY_04060 ENOG4105E98 transcriptional regulator DeoR family AXY_04070 ENOG4105DFW ABC transporter AXY_04090 ENOG4108HWW ABC transporter AXY_04110 ENOG4105C2F Histidine kinase AXY_04120 ENOG4105EQD regulatoR AXY_04130 ENOG4105DFW ABC transporter AXY_04140 ENOG4105C8Q Methyl-accepting chemotaxis AXY_04170 ENOG4105CIG ABC transporter AXY_04190 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AXY_04240 ENOG4105C7N Xanthine uracil vitamin C permease AXY_04260 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AXY_04270 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AXY_04280 ENOG4105C83 adenylosuccinate lyase AXY_04290 ENOG4105C8V SAICAR synthetase AXY_04300 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AXY_04310 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AXY_04320 ENOG4107QIK phosphoribosylformylglycinamidine synthase AXY_04340 ENOG4105CXB phosphoribosylaminoimidazole synthetase AXY_04350 ENOG4108V3E phosphoribosylglycinamide formyltransferase AXY_04360 ENOG4105DC1 bifunctional purine biosynthesis protein purh AXY_04370 ENOG4105C12 Phosphoribosylglycinamide synthetase AXY_04380 ENOG4105CJ1 ABC, transporter AXY_04390 ENOG4108IUW ABC transporter AXY_04410 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AXY_04430 ENOG4108R5T secreted protein AXY_04440 ENOG4105KGF protein, YerC YecD AXY_04450 ENOG4105EE0 oxidoreductase AXY_04460 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) AXY_04470 ENOG4105C4R Atp-dependent dna helicase AXY_04480 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AXY_04500 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AXY_04510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AXY_04520 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AXY_04530 ENOG4105CBD Diacylglycerol kinase AXY_04540 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AXY_04570 ENOG41067QW Transcriptional regulator AXY_04610 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AXY_04680 ENOG4105D6J arsenicaL-resistance protein AXY_04740 ENOG4105D7V transposase AXY_04770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXY_04890 ENOG4105CJZ response regulator AXY_04900 ENOG4105EWM Histidine kinase AXY_04910 ENOG4105C19 ABC transporter AXY_04940 ENOG4105DQ6 Transposase AXY_04970 ENOG4105ETU transcriptional activator (TenA AXY_04990 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AXY_05150 ENOG41086D8 Transcriptional regulator AXY_05180 ENOG4105EMN RNA polymerase sigma factor AXY_05190 ENOG4105C5I Dehydrogenase AXY_05200 ENOG4107QHE Choloylglycine hydrolase AXY_05250 ENOG410813F Putative esterase AXY_05280 ENOG4107WUB V-type ATPase 116 kDa subunit AXY_05320 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) AXY_05330 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) AXY_05340 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AXY_05350 ENOG4105HMI Membrane AXY_05400 ENOG4105KVH Transcriptional regulator AXY_05410 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AXY_05430 ENOG4105CJW magnesium transporter AXY_05440 ENOG4105C5Y PTS System AXY_05450 ENOG4105CS2 ec 3.2.1.21 AXY_05500 ENOG4105C37 (CBS) domain AXY_05520 ENOG4105DQ6 Transposase AXY_05680 ENOG4105CNT hydrolase family 2 AXY_05700 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AXY_05720 ENOG4105D9M gamma-glutamylcysteine synthetase AXY_05770 ENOG4105BZ1 (ABC) transporter AXY_05780 ENOG4105BZ1 (ABC) transporter AXY_05800 ENOG4105FCD Major Facilitator AXY_05850 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AXY_05890 ENOG4105CAG UPF0210 protein AXY_05910 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AXY_05920 ENOG4105CPQ Dehydrogenase AXY_05930 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AXY_05940 ENOG4105D4U had-superfamily hydrolase, subfamily iia AXY_05960 ENOG4105C5Y PTS System AXY_06000 ENOG4105BZU Histidine kinase AXY_06010 ENOG4105KJF protein tyrosine phosphatase AXY_06030 ENOG4107U9T Pfam:Ribonuclease_BN AXY_06040 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein AXY_06050 ENOG4105E5Q amino acid AbC transporter AXY_06070 ENOG4105DQ6 Transposase AXY_06080 ENOG4108ISG Major Facilitator AXY_06100 ENOG4105D8X mechanosensitive ion channel AXY_06120 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AXY_06170 ENOG4105DA5 (ABC) transporter AXY_06180 ENOG41069JR AXY_06200 ENOG41082BM Transcriptional regulator, arsr family AXY_06220 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AXY_06230 ENOG4105C8Q Methyl-accepting chemotaxis AXY_06260 ENOG410902V Modulates RecA activity (By similarity) AXY_06280 ENOG41067AE Membrane-bound metal-dependent hydrolase AXY_06290 ENOG4105CEN a g-specific adenine glycosylase AXY_06310 ENOG4105EVI UPF0374 protein AXY_06320 ENOG4107NBY Membrane AXY_06330 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AXY_06340 ENOG4108WBT adenosyltransferase AXY_06350 ENOG4105G5W regulator Fur family AXY_06470 ENOG4107XC4 flavin reductase domain protein, FMN-binding AXY_06480 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AXY_06550 ENOG4105EFI regulatoR AXY_06560 ENOG4105BZU Histidine kinase AXY_06590 ENOG41083S7 flagellar protein FlaG AXY_06600 ENOG4107RT6 flagellar hook-associated AXY_06610 ENOG4105MQ3 flagellar protein FliS AXY_06620 ENOG41069ZS flagellar protein AXY_06630 ENOG4105MS2 ribosomal subunit Interface protein AXY_06670 ENOG4107RNG ABC transporter AXY_06680 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AXY_06690 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AXY_06710 ENOG4105CAK Cell division ATP-binding protein ftsE AXY_06720 ENOG4105CRP Part of the ABC transporter FtsEX involved in AXY_06730 ENOG4105DR5 peptidase AXY_06740 ENOG4105CN1 protease AXY_06770 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AXY_06780 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AXY_06790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AXY_06800 ENOG41067S9 phage shock protein C, PspC AXY_06810 ENOG41086DT Membrane protein of unknown function AXY_06840 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AXY_06850 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AXY_06860 ENOG4107XGZ Hydrolase AXY_06870 ENOG4108S4C acetyltransferase AXY_06880 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AXY_06900 ENOG4105C3M thioredoxin reductase AXY_06920 ENOG4105F8D glycoside hydrolase family 4 AXY_06970 ENOG4108Z4K mutator MutT protein AXY_06980 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AXY_06990 ENOG4105CHW UPF0052 protein AXY_07000 ENOG4105CIE May be required for sporulation (By similarity) AXY_07010 ENOG4105KRI phosphocarrier protein (HPr AXY_07050 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AXY_07060 ENOG4105CID antiterminator AXY_07200 ENOG4108IUX (ABC) transporter AXY_07210 ENOG4105RHA ABC transporter, permease AXY_07220 ENOG4107VRP DNA repair exonuclease AXY_07250 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AXY_07280 ENOG4105NBU tryptophan transport protein AXY_07290 ENOG4105K59 histidine triad (HIT) protein AXY_07330 ENOG4105ENE Histidine kinase AXY_07340 ENOG4105WH1 Two component transcriptional regulator luxr family AXY_07350 ENOG4105BZ4 penicillin-binding protein AXY_07420 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AXY_07670 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein AXY_07690 ENOG4105C2F Histidine kinase AXY_07700 ENOG4107VQW regulatoR AXY_07740 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AXY_07770 ENOG4105CJQ hydrolase, family 31 AXY_07790 ENOG4105DSG hydrolase family 43 AXY_07800 ENOG4108RQ5 Beta-lactamase domain-containing protein AXY_07810 ENOG4105DF9 Lipoate-protein, ligase AXY_07830 ENOG41060YP AXY_07860 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AXY_07870 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AXY_07880 ENOG4105DHS permease protein AXY_07890 ENOG4105CM4 permease protein AXY_07900 ENOG4108IPW abc transporter atp-binding protein AXY_07930 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis AXY_07940 ENOG4107YTP response regulator receiver protein AXY_07950 ENOG4105C8Q Methyl-accepting chemotaxis AXY_07960 ENOG4105FDT acyl-CoA dehydrogenase AXY_07990 ENOG4105N80 Ferric uptake regulator, Fur family AXY_08010 ENOG4105FDK ABC transporter AXY_08040 ENOG41080E8 Transcriptional regulator, Spx MgsR family AXY_08050 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AXY_08060 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AXY_08070 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AXY_08080 ENOG4108UMI ABC transporter, permease AXY_08090 ENOG4105D01 (LipO)protein AXY_08100 ENOG4105C3K feS assembly ATPase SufC AXY_08110 ENOG4105JRK feS assembly protein SufD AXY_08130 ENOG4108UNV SUF system FeS assembly protein, NifU family AXY_08140 ENOG4105DIW FeS assembly protein SUFB AXY_08160 ENOG4107R8B 5'-nucleotidase AXY_08170 ENOG4105CPI Metal Dependent Phosphohydrolase AXY_08180 ENOG4108YTE sporulation protein YunB AXY_08190 ENOG4105D7V transposase AXY_08270 ENOG4105D7V transposase AXY_08280 ENOG4105D7V transposase AXY_08290 ENOG4105C88 aminopeptidase AXY_08320 ENOG4105SYT Methylenetetrahydrofolate reductase AXY_08350 ENOG4105C8J )-transporter AXY_08370 ENOG4105FAA peptidase M23 AXY_08380 ENOG4105MMD transcriptional regulator AXY_08390 ENOG4108W5N phosphatidylglycerophosphatase a AXY_08400 ENOG4105D6E homoserine dehydrogenase AXY_08410 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AXY_08430 ENOG41083MR nifu domain-containing protein AXY_08440 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AXY_08450 ENOG4105CAY ferredoxin--nadp reductase AXY_08460 ENOG4105CEP NADH dehydrogenase AXY_08490 ENOG4105VKD bioY protein AXY_08500 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AXY_08510 ENOG4105KRI phosphocarrier protein (HPr AXY_08520 ENOG4105C87 Aminotransferase class I and II AXY_08540 ENOG4107QYV phosphohexose isomerase AXY_08550 ENOG4105CN9 Peptidase m42 family protein AXY_08560 ENOG4105CAQ asparagine synthetase AXY_08570 ENOG4108SAX Membrane AXY_08580 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AXY_08620 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AXY_08650 ENOG4105C8T Leucyl-tRNA synthetase AXY_08670 ENOG4105DVE abc transporter atp-binding protein AXY_08680 ENOG4105FDP GntR family transcriptional regulator AXY_08720 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AXY_08740 ENOG4108R6K riboflavin synthase, subunit alpha AXY_08750 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AXY_08800 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AXY_08810 ENOG4105BZG amino acid carrier protein AXY_08820 ENOG4105CBX hi0933 family AXY_08850 ENOG4105YW5 deoR family transcriptional regulator AXY_08870 ENOG4108V15 phosphotransferase enzyme family AXY_08900 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AXY_08940 ENOG4108NKM UPF0354 protein AXY_08950 ENOG4108VDD TRNA binding domain protein AXY_08980 ENOG4105DFU Cell wall formation (By similarity) AXY_09020 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AXY_09030 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AXY_09040 ENOG4105ETE Transcriptional regulator (LacI family AXY_09050 ENOG4105E14 MotA TolQ exbB proton channel AXY_09060 ENOG4106VK6 Flagellar motor protein AXY_09080 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AXY_09090 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AXY_09100 ENOG4105BZU Histidine kinase AXY_09120 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) AXY_09150 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AXY_09180 ENOG4105KBJ sporulation protein ytfj AXY_09200 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AXY_09210 ENOG4107YZX Universal stress protein AXY_09230 ENOG4105SFS phosphoesterase RecJ domain protein AXY_09250 ENOG4105VV2 AXY_09260 ENOG4105C0B DNA polymerase III (alpha subunit) AXY_09270 ENOG4105C6K Malic enzyme AXY_09280 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AXY_09300 ENOG4105CTQ phosphohexokinase AXY_09310 ENOG4105CA9 Pyruvate kinase AXY_09320 ENOG4105FS0 cytoplasmic membrane protein AXY_09340 ENOG4108VMM UPF0756 membrane protein AXY_09350 ENOG4105BZN citrate synthase AXY_09360 ENOG4108HMX isocitrate dehydrogenase (NADP) AXY_09370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXY_09380 ENOG4105BZU Histidine kinase AXY_09390 ENOG4105C2M dna polymerase I AXY_09400 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AXY_09420 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AXY_09440 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AXY_09470 ENOG4108TDW sporulation protein YtxC AXY_09480 ENOG4105C22 threonyL-tRNA synthetase AXY_09500 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AXY_09510 ENOG4105VJV 50s ribosomal protein L35 AXY_09520 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AXY_09530 ENOG410696E Membrane AXY_09550 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AXY_09560 ENOG4105CN9 Peptidase m42 family protein AXY_09570 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AXY_09580 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AXY_09600 ENOG4105E4C Lytic transglycosylase catalytic AXY_09610 ENOG41067MF small acid-soluble spore protein AXY_09620 ENOG4108RWN rrna methyltransferase AXY_09640 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AXY_09650 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AXY_09660 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AXY_09670 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AXY_09690 ENOG4105DCG PHP domain protein AXY_09700 ENOG4105C98 muts2 protein AXY_09710 ENOG4105K63 Thioredoxin AXY_09720 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AXY_09740 ENOG4105PFC Transcriptional regulator AXY_09800 ENOG41067TZ transcriptional regulator, MarR family AXY_09810 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AXY_09820 ENOG4108XJQ germination protein AXY_09830 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AXY_09840 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AXY_09850 ENOG4105M59 Phosphodiesterase, mj0936 family AXY_09880 ENOG41069DP small acid-soluble spore protein AXY_09900 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AXY_09910 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AXY_09950 ENOG41068KH stage VI sporulation protein D AXY_09950 ENOG41068KH stage VI sporulation protein D AXY_09970 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AXY_09980 ENOG4105BZU Histidine kinase AXY_09990 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AXY_10030 ENOG4107QHF type ii secretion system protein e AXY_10040 ENOG4105CZX twitching motility protein AXY_10070 ENOG4106A3R peptidase AXY_10120 ENOG4105W5Q DNA repair protein (RadC AXY_10140 ENOG4105W5Q DNA repair protein (RadC AXY_10150 ENOG4105DFF Rod shape-determining protein mreb AXY_10160 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AXY_10190 ENOG4107QMS site-determining protein AXY_10220 ENOG4105C03 ribonuclease AXY_10240 ENOG4105X36 (ribosomal) protein AXY_10250 ENOG4105K46 50S ribosomal protein l27 AXY_10270 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AXY_10280 ENOG41090I5 UPF0735 ACT domain-containing protein AXY_10290 ENOG4105CQC Prephenate dehydratase AXY_10310 ENOG4106678 morphogenetic protein associated with SpoVID AXY_10320 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AXY_10330 ENOG4105CDY transcriptional regulatory protein AXY_10350 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AXY_10360 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AXY_10370 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AXY_10390 ENOG4105VIE preprotein translocase, subunit YajC AXY_10410 ENOG4105NAP AXY_10420 ENOG4108QG2 Membrane AXY_10430 ENOG4105CKP Polysaccharide Biosynthesis Protein AXY_10450 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AXY_10460 ENOG41067VP Protein of unknown function (DUF1049) AXY_10470 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AXY_10480 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AXY_10490 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AXY_10500 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AXY_10510 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AXY_10520 ENOG4108UTW Plays a role in the regulation of phosphate uptake AXY_10530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AXY_10540 ENOG4105CUT histidyl-tRNA synthetase AXY_10550 ENOG4105C9M aspartyl-trna synthetase AXY_10560 ENOG4108VCI transcription factor, rsfa family AXY_10570 ENOG4105D1H recombination factor protein RarA AXY_10590 ENOG4105C3J Cysteine desulfurase AXY_10600 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AXY_10650 ENOG4105C7H Helicase, RecD TraA family AXY_10660 ENOG41060CR AXY_10680 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AXY_10690 ENOG4105VBH UPF0297 protein AXY_10700 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AXY_10730 ENOG4105HHA aminodeoxychorismate lyase AXY_10740 ENOG4108VQJ O-methyltransferase AXY_10750 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AXY_10780 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXY_10800 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AXY_10810 ENOG4105CQW ribosome biogenesis GTPase YqeH AXY_10820 ENOG4105E2X shikimate dehydrogenase AXY_10830 ENOG410812S Rna-binding protein AXY_10840 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AXY_10850 ENOG4108WF2 Metal Dependent Phosphohydrolase AXY_10870 ENOG4108D32 Methyltransferase AXY_10890 ENOG4108UK2 deaminase AXY_10900 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AXY_10910 ENOG4105TQK DNA polymerase iii, delta' subunit AXY_10920 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AXY_10930 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) AXY_10940 ENOG4108ZRV stage ii sporulation protein p AXY_10960 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AXY_10970 ENOG4105CSA Coproporphyrinogen iii oxidase AXY_10980 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AXY_10990 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AXY_11000 ENOG4105CFG Acts as a chaperone (By similarity) AXY_11010 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AXY_11020 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AXY_11030 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AXY_11040 ENOG4105VCC 30S ribosomal protein S21 AXY_11050 ENOG4105KTH gatB Yqey AXY_11060 ENOG4105F7J membrane-bound serine protease AXY_11070 ENOG4105DI5 UPF0365 protein AXY_11090 ENOG41068P3 sporulation protein YqfC AXY_11110 ENOG4105C9A Phoh family AXY_11120 ENOG4105CTJ Metal Dependent Phosphohydrolase AXY_11130 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AXY_11140 ENOG4107YR5 Diacylglycerol kinase AXY_11150 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AXY_11160 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) AXY_11180 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AXY_11190 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AXY_11200 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AXY_11210 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AXY_11220 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXY_11250 ENOG4105EGD dinuclear metal center protein, YbgI family AXY_11270 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AXY_11320 ENOG4108UTW Plays a role in the regulation of phosphate uptake AXY_11340 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AXY_11350 ENOG4107RF6 penicillin-binding protein AXY_11390 ENOG4105WDJ 50S ribosomal protein L33 AXY_11400 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AXY_11420 ENOG4105DKQ ROK family AXY_11430 ENOG4105E0M Sulfatase AXY_11440 ENOG4105C5X domain protein AXY_11490 ENOG4106855 Competence protein AXY_11550 ENOG4105C0D helicase AXY_11560 ENOG4105WZW rhodanese family AXY_11570 ENOG4105KST dependent repressor AXY_11610 ENOG4105DC7 peptidase M24 AXY_11620 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AXY_11630 ENOG4105CD2 stage iii sporulation protein aa AXY_11650 ENOG4108CQH stage III sporulation protein AC AXY_11720 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AXY_11730 ENOG4108ZSR alkaline shock protein AXY_11740 ENOG4105M7K Involved in the transcription termination process (By similarity) AXY_11750 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AXY_11770 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AXY_11780 ENOG4105CTB Polyprenyl synthetase AXY_11790 ENOG4105DX0 Hemolysin A AXY_11810 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AXY_11820 ENOG4105S1Z Stage IV sporulation protein B AXY_11830 ENOG4107QQR Sporulation AXY_11840 ENOG4105K4I Scp-like extracellular AXY_11850 ENOG4105CFH Aspartokinase AXY_11880 ENOG4105CPP Dehydrogenase, E1 component AXY_11890 ENOG4105C7S Dehydrogenase AXY_11900 ENOG4108QEG Membrane AXY_11920 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AXY_11930 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AXY_11940 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AXY_11960 ENOG4108IXY short-chain dehydrogenase reductase AXY_11970 ENOG4108YZ4 nudix hydrolase AXY_11990 ENOG4105MZ9 stage II sporulation protein m AXY_12000 ENOG4105I3K Ferric uptake regulator, Fur family AXY_12010 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXY_12020 ENOG4105DZ1 carboxypeptidase AXY_12030 ENOG41082AN stage II sporulation protein AXY_12040 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AXY_12050 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXY_12080 ENOG4107ZE5 PPIases accelerate the folding of proteins AXY_12100 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AXY_12110 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AXY_12120 ENOG4105DZ1 carboxypeptidase AXY_12130 ENOG4108JIC nucleoside recognition domain protein AXY_12150 ENOG4105FE9 pseudouridine synthase AXY_12160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXY_12170 ENOG4105BZU Histidine kinase AXY_12210 ENOG4105T7X AXY_12220 ENOG4105C9U ATP-dependent DNA helicase RecQ AXY_12240 ENOG4108S6Z Negative regulator of genetic competence AXY_12250 ENOG4105F0V Cell wall hydrolase AXY_12260 ENOG4105MSI germination protein ypeb AXY_12270 ENOG4105EKQ RNA-directed DNA polymerase AXY_12300 ENOG4105E9Q Acyl-transferase AXY_12310 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AXY_12330 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AXY_12340 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AXY_12360 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AXY_12370 ENOG4105K70 DNA-binding protein AXY_12380 ENOG4105WP2 Tryptophan RNA-binding attenuator protein AXY_12400 ENOG4105EAH synthase AXY_12410 ENOG4105BZU Histidine kinase AXY_12430 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AXY_12440 ENOG4105D49 3-dehydroquinate synthase AXY_12450 ENOG4105KHN chorismate mutase AXY_12460 ENOG4105CIH Imidazole acetol-phosphate transaminase AXY_12480 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AXY_12510 ENOG41068YB TPR repeat-containing protein AXY_12520 ENOG4108SXZ UPF0302 protein AXY_12550 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AXY_12560 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AXY_12570 ENOG4108Z5K methylglyoxal synthase AXY_12580 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AXY_12590 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AXY_12610 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AXY_12620 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AXY_12630 ENOG4105DVT helicase AXY_12650 ENOG4105CHM Aminotransferase AXY_12660 ENOG4105C5S asparaginyl-tRNA synthetase AXY_12680 ENOG4105CSM endonuclease III AXY_12690 ENOG4105BZ4 penicillin-binding protein AXY_12700 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AXY_12740 ENOG4108UKS UPF0398 protein AXY_12750 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) AXY_12760 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AXY_12770 ENOG4105CTD carboxy-peptidase AXY_12790 ENOG41081VK Ribonuclease AXY_12800 ENOG4105VEQ Cold shock protein AXY_12820 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AXY_12830 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AXY_12850 ENOG4107RFY SbcCD D subunit AXY_12860 ENOG4105EYH Exonuclease AXY_12890 ENOG4105E0X reductase AXY_12930 ENOG410855V Acylphosphatase AXY_12940 ENOG4108ZMX Domain of unknown function (DU1801) AXY_12950 ENOG4105XYU peptidase (U32 family) AXY_12960 ENOG4105CFP Peptidase U32 AXY_13020 ENOG4105EPR degv family AXY_13070 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AXY_13080 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AXY_13090 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AXY_13110 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AXY_13120 ENOG4105C02 permease AXY_13150 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase AXY_13160 ENOG4105CHU acetyl-coa acetyltransferase AXY_13170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AXY_13190 ENOG4105CAH Chromate AXY_13210 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AXY_13240 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) AXY_13260 ENOG4105KXQ Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AXY_13320 ENOG4105QNR S1 RNA binding domain protein AXY_13340 ENOG4105C7B Threonine dehydratase AXY_13350 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AXY_13370 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AXY_13380 ENOG4105CM2 brancheD-chain amino acid aminotransferase AXY_13390 ENOG4105C5Q Transcriptional regulator AXY_13400 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AXY_13410 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AXY_13420 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AXY_13440 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AXY_13450 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AXY_13460 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AXY_13470 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AXY_13480 ENOG4108W76 histidinol phosphate phosphatase hisj family AXY_13510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXY_13520 ENOG4105K4P CoA-binding domain protein AXY_13530 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AXY_13540 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) AXY_13570 ENOG4105MI2 AXY_13590 ENOG4106F1P AAA ATPase, central domain protein AXY_13600 ENOG4108I0Z Aconitate hydratase AXY_13610 ENOG4105BZU Histidine kinase AXY_13620 ENOG4105VXM UPF0154 protein AXY_13650 ENOG4105VPS UPF0291 protein AXY_13670 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AXY_13680 ENOG4107ZE5 PPIases accelerate the folding of proteins AXY_13690 ENOG4105C8Q Methyl-accepting chemotaxis AXY_13710 ENOG4105CNG UPF0061 protein AXY_13720 ENOG4105CUB amino acid AXY_13750 ENOG4105D82 Glutamate dehydrogenase AXY_13770 ENOG4107YZP Rhodanese domain protein AXY_13800 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AXY_13810 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AXY_13930 ENOG4105C2M dna polymerase I AXY_14080 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AXY_14130 ENOG4106R3P AraC family transcriptional regulator AXY_14180 ENOG4108RU0 short-chain dehydrogenase reductase AXY_14200 ENOG4105DEN Luciferase family AXY_14210 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AXY_14220 ENOG4106F1P AAA ATPase, central domain protein AXY_14240 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AXY_14250 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AXY_14260 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AXY_14270 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AXY_14320 ENOG4105MCT stage V sporulation protein S AXY_14330 ENOG4105D48 metallophosphoesterase AXY_14340 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AXY_14350 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AXY_14360 ENOG4105CEV competence damage-inducible protein AXY_14370 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AXY_14410 ENOG4105FDP GntR family transcriptional regulator AXY_14440 ENOG4105CNU cell division protein FtsK AXY_14450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AXY_14470 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AXY_14480 ENOG4108S0H Dipicolinic acid synthetase, b subunit AXY_14490 ENOG4105E35 Dipicolinate synthase subunit A AXY_14520 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AXY_14530 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AXY_14540 ENOG4105DTN riboflavin biosynthesis protein ribF AXY_14550 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AXY_14560 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AXY_14570 ENOG4105W7A Protein of unknown function (DUF503) AXY_14580 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AXY_14590 ENOG4105VHM ribosomal protein AXY_14600 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AXY_14610 ENOG4105CHV Transcription elongation factor NusA AXY_14620 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AXY_14630 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AXY_14640 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AXY_14650 ENOG4105DZP Membrane-associated zinc metalloprotease AXY_14660 ENOG4105KNE Phosphatidate cytidylyltransferase AXY_14670 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AXY_14680 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AXY_14700 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AXY_14710 ENOG4105CE9 30S ribosomal protein S2 AXY_14750 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXY_14760 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AXY_14780 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis AXY_14790 ENOG4105CBS Chea signal transduction histidine kinase AXY_14800 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AXY_14820 ENOG4105FZW flagellar biosynthesis regulator FlhF AXY_14830 ENOG4105D7B Flagellar biosynthesis protein flha AXY_14840 ENOG4105D00 flagellar biosynthetic protein flhB AXY_14850 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AXY_14860 ENOG4105VS8 Flagellar biosynthetic protein fliq AXY_14870 ENOG4105CN7 Flagellar biosynthetic protein FliP AXY_14890 ENOG4107YTP response regulator receiver protein AXY_14900 ENOG4105DD5 Flagellar motor switch protein AXY_14910 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AXY_14930 ENOG41068WV flagellar FlbD family protein AXY_14940 ENOG4108JQA flagellar AXY_14960 ENOG410822I Flagellar hook capping protein AXY_15040 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AXY_15050 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AXY_15060 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AXY_15070 ENOG4108ZC9 flagellar basal-body rod protein flgc AXY_15080 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AXY_15090 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) AXY_15100 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AXY_15110 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AXY_15120 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXY_15130 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AXY_15140 ENOG4105C79 DNA protecting protein DprA AXY_15150 ENOG4105VM1 flagellar AXY_15170 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AXY_15180 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AXY_15190 ENOG4105C3F Signal peptidase i AXY_15200 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AXY_15210 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AXY_15220 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AXY_15230 ENOG4105VB6 UPF0109 protein AXY_15240 ENOG4105K5M 30s ribosomal protein S16 AXY_15260 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) AXY_15270 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AXY_15280 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AXY_15290 ENOG4108CPA Protein of unknown function (DUF1128) AXY_15300 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AXY_15310 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AXY_15320 ENOG4105CHR reductase AXY_15330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AXY_15340 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AXY_15350 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) AXY_15360 ENOG4105CB5 ATP-dependent DNA helicase recG AXY_15370 ENOG4105DP4 dak2 domain fusion protein ylov AXY_15380 ENOG4108ZAA Alkaline-shock protein AXY_15390 ENOG4105VB9 50S ribosomal protein l28 AXY_15400 ENOG4105FJ0 thiamine AXY_15410 ENOG4105DJV ribulose-phosphate 3-epimerase AXY_15420 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AXY_15430 ENOG4105D9P serine threonine protein kinase AXY_15440 ENOG4108ZF3 Phosphatase AXY_15450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AXY_15460 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AXY_15470 ENOG4105C25 Primosomal protein n' AXY_15480 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AXY_15490 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AXY_15500 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AXY_15510 ENOG4105KC4 UPF0296 protein AXY_15520 ENOG4105DSJ YicC domain protein AXY_15540 ENOG4105F23 Fibronectin-binding protein AXY_15600 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AXY_15610 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AXY_15620 ENOG4105CD3 dihydroorotase AXY_15630 ENOG4105CXT aspartate transcarbamylase AXY_15650 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AXY_15660 ENOG4105C34 Pseudouridine synthase AXY_15680 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AXY_15700 ENOG4105DBK s4 domain protein AXY_15710 ENOG41067XK integral membrane protein AXY_15720 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AXY_15730 ENOG4105DFA alanine racemase domain protein AXY_15740 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AXY_15770 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXY_15780 ENOG4105FFI sigma-e processing peptidase spoiiga AXY_15790 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AXY_15800 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AXY_15810 ENOG4105K67 small basic protein AXY_15830 ENOG4108R2U division initiation protein AXY_15840 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AXY_15860 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AXY_15870 ENOG4105CNI cell division protein FtsW AXY_15880 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AXY_15890 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AXY_15900 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AXY_15910 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AXY_15920 ENOG4105CJN penicillin-binding protein AXY_15930 ENOG4105CJN penicillin-binding protein AXY_15940 ENOG41068DC Essential cell division protein (By similarity) AXY_15950 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AXY_15960 ENOG4108V6E Cell division protein mraZ AXY_15980 ENOG4108VCI transcription factor, rsfa family AXY_15990 ENOG41067VY 50S ribosomal protein L32 AXY_16000 ENOG4105KNH Nucleic acid-binding protein AXY_16010 ENOG4105CDE UPF0348 protein AXY_16020 ENOG41063PX domain protein AXY_16030 ENOG4105H20 Sporulation integral membrane protein YlbJ AXY_16040 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AXY_16050 ENOG4106H78 methyltransferase AXY_16060 ENOG4105WUC UPF0298 protein AXY_16090 ENOG41080XQ Signal transduction protein with cbs domains AXY_16140 ENOG4105ECY inositol monophosphatase AXY_16150 ENOG4105WBI UPF0223 protein AXY_16160 ENOG4108ZJ4 polysaccharide deacetylase AXY_16220 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AXY_16230 ENOG4106EHS UPF0356 protein AXY_16240 ENOG4105CN5 Metallo-Beta-Lactamase AXY_16250 ENOG4107ZYR domain protein AXY_16260 ENOG4105BZ1 (ABC) transporter AXY_16270 ENOG4105BZ1 (ABC) transporter AXY_16280 ENOG4105D8X mechanosensitive ion channel AXY_16300 ENOG4105UIN AXY_16340 ENOG4105C3F Signal peptidase i AXY_16400 ENOG41090VF Stage v sporulation protein ac AXY_16410 ENOG4105CZ3 stage V sporulation protein ad AXY_16450 ENOG4105C7K acetolactate synthase AXY_16460 ENOG4108ZP8 Acetolactate synthase small subunit AXY_16470 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AXY_16480 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AXY_16490 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AXY_16500 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AXY_16510 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AXY_16530 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AXY_16540 ENOG4105EMN RNA polymerase sigma factor AXY_16560 ENOG4105DVE abc transporter atp-binding protein AXY_16570 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AXY_16580 ENOG4105FBA Phospholipase Carboxylesterase AXY_16610 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AXY_16630 ENOG4105II7 pyrroline-5-carboxylate reductase AXY_16680 ENOG4105CDA abc transporter atp-binding protein AXY_16690 ENOG4105E5Q amino acid AbC transporter AXY_16700 ENOG4108HW3 (ABC) transporter AXY_16710 ENOG4108X4Q Hydrolase AXY_16750 ENOG4105CVG Homoserine O-transsuccinylase AXY_16760 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AXY_16770 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AXY_16780 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AXY_16790 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AXY_16800 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AXY_16810 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AXY_16830 ENOG4107SM1 it plays a direct role in the translocation of protons across the membrane (By similarity) AXY_16870 ENOG4105VEQ Cold shock protein AXY_16890 ENOG41062D9 Histidine kinase AXY_16900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXY_16910 ENOG4107UWA esterase AXY_16950 ENOG4108X4Q Hydrolase AXY_16960 ENOG410667J hydrolase AXY_16990 ENOG4107URF beta-phospho-glucomutase AXY_17020 ENOG4108WPJ Ferritin-like domain AXY_17030 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AXY_17040 ENOG4107QIV Cytochrome c biogenesis protein AXY_17050 ENOG4105XXY Thioredoxin AXY_17170 ENOG4105DER m42 family AXY_17190 ENOG4108IUW ABC transporter AXY_17210 ENOG4105C34 Pseudouridine synthase AXY_17260 ENOG4105VZ8 Transcriptional regulator AXY_17270 ENOG4105CID antiterminator AXY_17280 ENOG4105C5Y PTS System AXY_17290 ENOG4105CS2 ec 3.2.1.21 AXY_17310 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AXY_17320 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AXY_17360 ENOG4108IUM Glycogen debranching enzyme AXY_17370 ENOG4108IUM Glycogen debranching enzyme AXY_17380 ENOG4107T9C Alpha amylase catalytic region AXY_17390 ENOG4105BZU Histidine kinase AXY_17410 ENOG4105EG2 ABC transporter, permease AXY_17430 ENOG4107FKK extracellular solute-binding protein family 1 AXY_17440 ENOG4107SDU Methyl-accepting chemotaxis AXY_17450 ENOG4105FKQ transcriptional regulator AXY_17470 ENOG4105BZ1 (ABC) transporter AXY_17480 ENOG4105BZ1 (ABC) transporter AXY_17500 ENOG4105C01 Dihydroxy-acid dehydratase AXY_17510 ENOG4105BZU Histidine kinase AXY_17530 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AXY_17540 ENOG4105C3S Mate efflux family protein AXY_17570 ENOG4105DSG hydrolase family 43 AXY_17630 ENOG4105BZ1 (ABC) transporter AXY_17650 ENOG4105E1K spore germination protein AXY_17690 ENOG4105CNI cell division protein FtsW AXY_17710 ENOG41082BV acetyltransferase AXY_17720 ENOG4105H67 Protein of unknown function (DUF421) AXY_17780 ENOG4105CJW magnesium transporter AXY_17800 ENOG4105EMS pseudouridine synthase AXY_17810 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AXY_17830 ENOG4105MIX Adenylate cyclase AXY_17840 ENOG4105T58 Dithiol-disulfide isomerase AXY_17860 ENOG4105CZM Major Facilitator AXY_17870 ENOG4105DPN Oligoendopeptidase f AXY_17900 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) AXY_17940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AXY_17950 ENOG4108JQ7 (ABC) transporter AXY_17990 ENOG4105C31 Tryptophanyl-tRNA synthetase AXY_18030 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AXY_18040 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AXY_18070 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AXY_18080 ENOG4107V6Q Cyclic nucleotide-binding domain AXY_18090 ENOG4105VG1 fes assembly suf system protein AXY_18100 ENOG4108MXZ Esterase AXY_18110 ENOG4108KP7 hydrolase AXY_18130 ENOG4107AYK membrAne AXY_18140 ENOG4105EPR degv family AXY_18150 ENOG4105YHS UPF0344 protein AXY_18160 ENOG4105Z8B NlpC/P60 family AXY_18160 ENOG4105Z8B NlpC/P60 family AXY_18170 ENOG4105FF2 Type I DHQase AXY_18190 ENOG4105C5Y PTS System AXY_18230 ENOG4108NEV two component transcriptional regulator, LytTR family AXY_18240 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AXY_18250 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AXY_18270 ENOG4105XZU Preprotein translocase, subunit SecG AXY_18280 ENOG4105KRI phosphocarrier protein (HPr AXY_18290 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AXY_18340 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AXY_18350 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AXY_18360 ENOG4105CP7 Triose-phosphate isomerase AXY_18370 ENOG4105BZA Phosphoglycerate kinase AXY_18410 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AXY_18420 ENOG4105WZB UPF0342 protein AXY_18470 ENOG4105C9Q fumarate hydratase class II AXY_18480 ENOG4108VXD carboxy-peptidase AXY_18520 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AXY_18540 ENOG4106HBX Transcriptional Regulator AraC Family AXY_18590 ENOG4105XTG Pfam:DUF156 AXY_18610 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AXY_18620 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AXY_18650 ENOG4108V2W Carbonate dehydratase AXY_18660 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AXY_18680 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AXY_18700 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AXY_18710 ENOG41087YS Phage shock protein A AXY_18720 ENOG41087YS Phage shock protein A AXY_18740 ENOG4105NI3 Protein of unknown function (DUF3237) AXY_18770 ENOG4105BZU Histidine kinase AXY_18780 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AXY_18800 ENOG4105I03 Flagellin AXY_18880 ENOG4105I03 Flagellin AXY_18890 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AXY_18900 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AXY_18910 ENOG4105MKD AXY_18920 ENOG4105DTJ flagellar hook-associated protein AXY_18930 ENOG4105E1Q flagellar hook-associated protein AXY_18960 ENOG4105RU3 AXY_18970 ENOG41081UC Inherit from COG: Competence protein AXY_19000 ENOG4105WH1 Two component transcriptional regulator luxr family AXY_19010 ENOG4105BZU Histidine kinase AXY_19030 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AXY_19040 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AXY_19050 ENOG4107YY3 extracellular solute-binding protein family 1 AXY_19060 ENOG41075H3 AraC family transcriptional regulator AXY_19070 ENOG4105C2F Histidine kinase AXY_19080 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AXY_19100 ENOG4107RVG penicillin-binding protein AXY_19230 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXY_19300 ENOG4107SET aldo keto reductase AXY_19310 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AXY_19320 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AXY_19340 ENOG4105C4C beta-galactosidase AXY_19350 ENOG4105FTV AraC Family Transcriptional Regulator AXY_19360 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AXY_19390 ENOG4108UT2 hemolysin iii AXY_19400 ENOG4108KGH TRANSCRIPTIONal AXY_19420 ENOG4105BZU Histidine kinase AXY_19470 ENOG4105C8Q Methyl-accepting chemotaxis AXY_19490 ENOG4105CTQ phosphohexokinase AXY_19520 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AXY_19530 ENOG4105CNN ABC, transporter AXY_19540 ENOG4105C2J ABC transporter AXY_19550 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AXY_19560 ENOG4108RVA ribokinase AXY_19570 ENOG4105ETE Transcriptional regulator (LacI family AXY_19600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AXY_19610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AXY_19630 ENOG4105E5G Alpha beta hydrolase fold AXY_19640 ENOG4105UQX Mate efflux family protein AXY_19650 ENOG4105C8Q Methyl-accepting chemotaxis AXY_19660 ENOG4107SET aldo keto reductase AXY_19690 ENOG4105BZ1 (ABC) transporter AXY_19700 ENOG4105BZ1 (ABC) transporter AXY_19740 ENOG4105C6Y Udp-glucose 6-dehydrogenase AXY_19800 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AXY_19820 ENOG41069HH 4-oxalocrotonate tautomerase AXY_19840 ENOG4105C28 cystathionine AXY_19920 ENOG4105D9M gamma-glutamylcysteine synthetase AXY_19940 ENOG4105GIG AXY_19950 ENOG4105ENY Ethanolamine utilization protein eutH AXY_20030 ENOG4108KMV Glycosyl transferase (Group 1 AXY_20050 ENOG4105CPK Glycosyl transferase (Group 1 AXY_20080 ENOG4105D3Q Sugar transferase AXY_20100 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AXY_20110 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AXY_20120 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AXY_20130 ENOG4107YJ4 chain length determinant protein AXY_20140 ENOG4105HTX biosynthesis protein AXY_20150 ENOG4105CMB EAL domain-containing protein AXY_20180 ENOG4108KGH TRANSCRIPTIONal AXY_20190 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AXY_20210 ENOG4107SJB teichoic acid biosynthesis AXY_20250 ENOG4107SJB teichoic acid biosynthesis AXY_20260 ENOG4107SJB teichoic acid biosynthesis AXY_20280 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase AXY_20290 ENOG4107RZX Teichoic acid biosynthesis protein AXY_20300 ENOG4105ESV Glycosyl transferase, family 4 AXY_20330 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AXY_20360 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AXY_20380 ENOG4105CGA flagellar basal-body rod protein FlgG AXY_20400 ENOG4105DFF Rod shape-determining protein mreb AXY_20410 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AXY_20440 ENOG4105FRN stage II sporulation protein AXY_20460 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AXY_20480 ENOG4106778 Protein of unknown function (DUF1146) AXY_20490 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AXY_20500 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AXY_20510 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AXY_20520 ENOG4108YZG isomerase AXY_20530 ENOG4107WAU Protein tyrosine phosphatase AXY_20540 ENOG410815N Probably functions as a manganese efflux pump (By similarity) AXY_20550 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AXY_20570 ENOG4108ZXQ stage ii sporulation protein r AXY_20580 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AXY_20590 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AXY_20600 ENOG4107104 thymidine kinase AXY_20610 ENOG41082DI 50s ribosomal protein l31 AXY_20630 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AXY_20640 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AXY_20650 ENOG4105D2N Aldolase AXY_20660 ENOG410812K response regulator receiver protein AXY_20670 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AXY_20680 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) AXY_20710 ENOG4105C75 arginyL-tRNA synthetase AXY_20730 ENOG4105BZ4 penicillin-binding protein AXY_20750 ENOG4105DCI Phosphohydrolase AXY_20760 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AXY_20770 ENOG4108IJ2 phosphate acetyltransferase AXY_20780 ENOG4108VKI Cell wall hydrolase AXY_20800 ENOG4105DQ6 Transposase AXY_20840 ENOG4105C9U ATP-dependent DNA helicase RecQ AXY_20870 ENOG4105C5H ABC transporter AXY_20880 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AXY_20910 ENOG41090WU lipolytic protein G-D-S-L family AXY_20950 ENOG4105WH1 Two component transcriptional regulator luxr family AXY_20990 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AXY_21030 ENOG4105C5H ABC transporter AXY_21040 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AXY_21060 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AXY_21080 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AXY_21100 ENOG4108I0Q anthranilate phosphoribosyltransferase AXY_21110 ENOG4105CRQ synthase (Component I) AXY_21130 ENOG41069ER domain protein AXY_21150 ENOG4105C8Q Methyl-accepting chemotaxis AXY_21170 ENOG4105MU9 integral membrane protein AXY_21180 ENOG4105DRS transport system, permease AXY_21220 ENOG4105CS2 ec 3.2.1.21 AXY_21230 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AXY_21240 ENOG4105CMR udp-glucose 4-epimerase AXY_21250 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase AXY_21260 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AXY_21270 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AXY_21330 ENOG410667J hydrolase AXY_21370 ENOG4105C59 p-type ATPase AXY_21410 ENOG4105CE4 GlcNAc 6-P deacetylase AXY_21420 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AXY_21430 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) AXY_21440 ENOG4105EEM helicase AXY_21450 ENOG4105KME endoribonuclease L-psp AXY_21460 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AXY_21470 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AXY_21500 ENOG4105CMD Transcriptional regulator, GntR family AXY_21550 ENOG4105KTU Transcriptional regulator, arsr family AXY_21570 ENOG4105C59 p-type ATPase AXY_21580 ENOG4105C8Y Acetylornithine aminotransferase AXY_21590 ENOG4105CAS nag kinase AXY_21600 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AXY_21610 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AXY_21640 ENOG4105DWK Membrane AXY_21720 ENOG4108UT2 hemolysin iii AXY_21780 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ AXY_21790 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AXY_21800 ENOG4105I82 acetyl xylan esterase AXY_21810 ENOG4105VZJ PTS System AXY_21820 ENOG4105CK1 PTS System AXY_21830 ENOG4105VCP PTS System AXY_21840 ENOG4105CS2 ec 3.2.1.21 AXY_21850 ENOG4105EMD TRANSCRIPTIONal AXY_21860 ENOG4105DG6 mannose-6-phosphate isomerase AXY_21880 ENOG4105CJ1 ABC, transporter AXY_21910 ENOG4107414 GntR family transcriptional regulator AXY_21920 ENOG4105CG3 alpha amylase, catalytic region AXY_21930 ENOG4105C5Y PTS System AXY_21940 ENOG4105IJJ transcriptional regulator, crp fnr family AXY_21950 ENOG4105C59 p-type ATPase AXY_21960 ENOG4105DR5 peptidase AXY_21980 ENOG4105PTM secreted protein AXY_21990 ENOG4108UW5 maltose o-acetyltransferase AXY_22020 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AXY_22070 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AXY_22080 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AXY_22120 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AXY_22130 ENOG4105C8Q Methyl-accepting chemotaxis AXY_22180 ENOG4105WG9 Conserved Protein AXY_22190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXY_22210 ENOG4105CHR reductase AXY_22250 ENOG410667J hydrolase AXY_22270 ENOG4105DQ6 Transposase AXY_22330 ENOG4105BZ1 (ABC) transporter AXY_22340 ENOG4105I82 acetyl xylan esterase AXY_22350 ENOG4105CPC Aldo Keto reductase AXY_22380 ENOG4105CKB glycosidase AXY_22390 ENOG4105EG2 ABC transporter, permease AXY_22440 ENOG4105ETE Transcriptional regulator (LacI family AXY_22450 ENOG4105HY2 Glycosidase related protein AXY_22460 ENOG4105DFY n-acylglucosamine 2-epimerase AXY_22470 ENOG4105VZJ PTS System AXY_22480 ENOG4105CK1 PTS System AXY_22490 ENOG4105CK1 PTS System AXY_22500 ENOG4105VCP PTS System AXY_22510 ENOG4105CS2 ec 3.2.1.21 AXY_22520 ENOG4105EMD TRANSCRIPTIONal AXY_22530 ENOG4105D3P Mannan endo-1,4-beta-mannosidase AXY_22540 ENOG4105DG6 mannose-6-phosphate isomerase AXY_22580 ENOG4105CS2 ec 3.2.1.21 AXY_22590 ENOG4105C8Q Methyl-accepting chemotaxis AXY_22630 ENOG4105EVU fructokinase AXY_22670 ENOG4105DQ6 Transposase AXY_22690 ENOG4108ZJ4 polysaccharide deacetylase AXY_22740 ENOG4107QRS glycosyltransferase group 2 family protein AXY_22760 ENOG4105CNT hydrolase family 2 AXY_22800 ENOG4105DY9 regulatoR AXY_22810 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AXY_22820 ENOG4107QRS glycosyltransferase group 2 family protein AXY_22860 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AXY_22880 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein AXY_22910 ENOG4105D5D udp-galactopyranose mutase AXY_22960 ENOG4105D01 (LipO)protein AXY_22970 ENOG4108UMI ABC transporter, permease AXY_22980 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AXY_23020 ENOG4108ZJ4 polysaccharide deacetylase AXY_23030 ENOG4108YBP pseudouridine synthase AXY_23060 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AXY_23070 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AXY_23100 ENOG4105BZU Histidine kinase AXY_23110 ENOG4106HK8 GPR1 FUN34 yaaH family protein AXY_23120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXY_23130 ENOG41073TP transcriptional regulator AXY_23140 ENOG4105C01 Dihydroxy-acid dehydratase AXY_23170 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AXY_23180 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AXY_23200 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AXY_23220 ENOG4105C1J atp-dependent rna helicase AXY_23230 ENOG4107RUE extracellular solute-binding protein family 1 AXY_23240 ENOG4105D38 putrescine abc transporter AXY_23250 ENOG4105F38 ABC transporter, permease AXY_23260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AXY_23270 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AXY_23290 ENOG4105BZ1 (ABC) transporter AXY_23300 ENOG4105BZ1 (ABC) transporter AXY_23320 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AXY_23330 ENOG4107R8N Glycosyl transferase, family 2 AXY_23340 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AXY_23360 ENOG4105CHH sulfate transporter AXY_23370 ENOG4105FKZ Methyl-accepting chemotaxis AXY_23410 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AXY_23420 ENOG4105VMP Transcriptional regulator AXY_23560 ENOG4105C7H Helicase, RecD TraA family AXY_23570 ENOG4105D9P serine threonine protein kinase AXY_23580 ENOG4105DZR Type I site-specific deoxyribonuclease AXY_23590 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AXY_23630 ENOG4105C37 (CBS) domain AXY_23650 ENOG4108V7D UPF0397 protein AXY_23670 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AXY_23750 ENOG4105C0H protease AXY_23760 ENOG4105Q2H domain protein AXY_23790 ENOG4105BZU Histidine kinase AXY_23800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXY_23820 ENOG4105E4C Lytic transglycosylase catalytic AXY_23840 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AXY_23850 ENOG4105CDU Replicative dna helicase AXY_23860 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AXY_23870 ENOG4105BZR domain protein AXY_23880 ENOG4108XMW Membrane AXY_23890 ENOG4105U0R haloacid dehalogenase-like hydrolase AXY_23900 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AXY_23910 ENOG4107QMU Mate efflux family protein AXY_23920 ENOG4108JQ1 Dehydrogenase AXY_23930 ENOG4105D6A Electron transport complex AXY_23940 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AXY_23950 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AXY_23960 ENOG4108UUM single-stranded DNA-binding protein AXY_23970 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AXY_23980 ENOG4105C3G gtp-binding protein AXY_23990 ENOG4105VDK protein, conserved in bacteria AXY_24010 ENOG4108ZDA Sporulation protein YyaC AXY_24020 ENOG4105FA0 parb-like partition protein AXY_24030 ENOG4107QJE Chromosome Partitioning Protein AXY_24040 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) AXY_24050 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AXY_24060 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AXY_24070 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AXY_24090 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AXY_24100 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AXY_24110 ENOG4105VG0 50S ribosomal protein l34