locus-tag	class	description
AXY_00020	COG0592	DNA-directed DNA polymerase activity
AXY_00030	COG2501	S4 domain
AXY_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXY_00060	COG0187	DNA topoisomerase II activity
AXY_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXY_00080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AXY_00090	COG0517	IMP dehydrogenase activity
AXY_00090	COG0516	GMP reductase activity
AXY_00110	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AXY_00120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXY_00130	COG4989	oxidoreductase activity
AXY_00150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AXY_00160	COG0697	spore germination
AXY_00170	COG3858	chitin binding
AXY_00170	COG1388	LysM domain
AXY_00180	COG0590	tRNA wobble adenosine to inosine editing
AXY_00190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AXY_00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AXY_00210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXY_00250	COG4608	Belongs to the ABC transporter superfamily
AXY_00260	COG0601	transmembrane transport
AXY_00310	COG3870	Protein conserved in bacteria
AXY_00320	COG1728	Protein conserved in bacteria
AXY_00330	COG0470	DNA polymerase III
AXY_00340	COG1774	PSP1 C-terminal conserved region
AXY_00350	COG4467	Involved in initiation control of chromosome replication
AXY_00360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AXY_00370	COG2827	Endonuclease containing a URI domain
AXY_00380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXY_00390	COG2002	toxin-antitoxin pair type II binding
AXY_00400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_00400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_00410	COG0084	hydrolase, TatD family'
AXY_00420	COG3584	3D domain protein
AXY_00420	COG3583	domain protein
AXY_00430	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AXY_00440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXY_00450	COG3344	reverse transcriptase
AXY_00500	COG4466	Protein conserved in bacteria
AXY_00510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXY_00520	COG2088	sporulation resulting in formation of a cellular spore
AXY_00530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXY_00540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXY_00550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXY_00560	COG0193	aminoacyl-tRNA hydrolase activity
AXY_00580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXY_00590	COG2002	toxin-antitoxin pair type II binding
AXY_00600	COG2244	polysaccharide biosynthetic process
AXY_00610	COG3956	TIGRFAM MazG family protein
AXY_00620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AXY_00660	COG1098	S1 RNA binding domain
AXY_00750	COG1122	ATPase activity
AXY_00770	COG2208	phosphoserine phosphatase activity
AXY_00780	COG2304	oxidoreductase activity
AXY_00790	COG0515	serine threonine protein kinase
AXY_00800	COG0037	tRNA processing
AXY_00820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXY_00830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AXY_00840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AXY_00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXY_00860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AXY_00870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXY_00880	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AXY_00890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXY_00900	COG1396	sequence-specific DNA binding
AXY_00910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXY_00920	COG1307	EDD domain protein, DegV family
AXY_00930	COG1285	pathogenesis
AXY_00950	COG3880	PFAM UvrB UvrC protein
AXY_00960	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AXY_00970	COG0542	response to heat
AXY_00980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AXY_00990	COG4956	integral membrane protein (PIN domain superfamily)
AXY_01000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXY_01010	COG1045	serine acetyltransferase
AXY_01020	COG0215	cysteine-tRNA ligase activity
AXY_01030	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AXY_01040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXY_01050	COG3688	RNA-binding protein containing a PIN domain
AXY_01080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXY_01090	COG0250	Participates in transcription elongation, termination and antitermination
AXY_01100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXY_01110	COG0081	regulation of translation
AXY_01120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXY_01130	COG0222	ribosome binding
AXY_01140	COG2813	Specifically methylates the guanine in position
AXY_01150	COG0085	RNA polymerase activity
AXY_01160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXY_01170	COG1358	cellular component organization or biogenesis
AXY_01180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXY_01190	COG0049	tRNA binding
AXY_01200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXY_01210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXY_01220	COG0051	transcription antitermination factor activity, RNA binding
AXY_01230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXY_01240	COG0088	Forms part of the polypeptide exit tunnel
AXY_01250	COG0089	rRNA binding
AXY_01260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXY_01270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXY_01280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXY_01290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXY_01300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXY_01310	COG0255	Belongs to the universal ribosomal protein uL29 family
AXY_01320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXY_01330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXY_01340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXY_01350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXY_01360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXY_01370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXY_01380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXY_01390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AXY_01410	COG1841	ribosomal large subunit assembly
AXY_01430	COG0201	protein transport
AXY_01440	COG0563	adenylate kinase activity
AXY_01460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXY_01470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXY_01480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXY_01490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXY_01500	COG0202	RNA polymerase activity
AXY_01510	COG0203	ribosomal protein L17
AXY_01520	COG1122	ATPase activity
AXY_01530	COG1122	ATPase activity
AXY_01540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AXY_01550	COG0101	tRNA pseudouridine synthase activity
AXY_01560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXY_01570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXY_01670	COG0577	efflux transmembrane transporter activity
AXY_01680	COG1136	(ABC) transporter
AXY_01690	COG0515	serine threonine protein kinase
AXY_01690	COG2815	serine threonine protein kinase
AXY_01720	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AXY_01740	COG3546	catalase activity
AXY_01750	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AXY_01760	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_01770	COG0489	protein tyrosine kinase activity
AXY_01790	COG0726	polysaccharide deacetylase
AXY_01810	COG4974	Belongs to the 'phage' integrase family
AXY_01830	COG1396	sequence-specific DNA binding
AXY_01910	COG3617	BRO family, N-terminal domain
AXY_01940	COG0629	single-stranded DNA binding
AXY_02120	COG0740	serine-type endopeptidase activity
AXY_02300	COG4824	toxin secretion phage lysis holin
AXY_02310	COG0739	heme binding
AXY_02340	COG0463	Glycosyl transferase, family 2
AXY_02340	COG0457	Tetratricopeptide repeat
AXY_02360	COG0463	Glycosyl transferase, family 2
AXY_02380	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AXY_02390	COG4856	YbbR-like protein
AXY_02400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXY_02410	COG0662	Cupin 2, conserved barrel domain protein
AXY_02450	COG4684	Psort location CytoplasmicMembrane, score
AXY_02460	COG2860	membrane
AXY_02470	COG1473	amidohydrolase
AXY_02490	COG0789	Transcriptional regulator
AXY_02500	COG0789	Transcriptional regulator
AXY_02520	COG2746	aminoglycoside 3-N-acetyltransferase activity
AXY_02560	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AXY_02570	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AXY_02590	COG0295	cytidine deaminase activity
AXY_02600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AXY_02620	COG2207	Transcriptional regulator
AXY_02620	COG4753	response regulator
AXY_02630	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_02640	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AXY_02670	COG5578	integral membrane protein
AXY_02680	COG2972	Histidine kinase
AXY_02700	COG4209	transmembrane transport
AXY_02710	COG0395	ABC-type sugar transport system, permease component
AXY_02730	COG1312	Catalyzes the dehydration of D-mannonate
AXY_02740	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_02750	COG0800	Aldolase
AXY_02770	COG1904	glucuronate isomerase
AXY_02780	COG2115	Belongs to the xylose isomerase family
AXY_02790	COG1070	Carbohydrate kinase
AXY_02810	COG0351	phosphomethylpyrimidine kinase
AXY_02820	COG0083	homoserine kinase activity
AXY_02850	COG1012	belongs to the aldehyde dehydrogenase family
AXY_02860	COG0346	lactoylglutathione lyase activity
AXY_02880	COG4585	Histidine kinase
AXY_02890	COG2197	response regulator
AXY_02900	COG1131	(ABC) transporter
AXY_02930	COG1940	carbohydrate kinase activity
AXY_02940	COG1760	l-serine dehydratase
AXY_02960	COG1304	FMN binding
AXY_02980	COG4120	Belongs to the binding-protein-dependent transport system permease family
AXY_02990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXY_03000	COG1119	ATPase activity
AXY_03010	COG1012	belongs to the aldehyde dehydrogenase family
AXY_03010	COG1454	alcohol dehydrogenase
AXY_03030	COG1882	Formate acetyltransferase
AXY_03040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AXY_03050	COG1764	response to oxidative stress
AXY_03060	COG0716	FMN binding
AXY_03090	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AXY_03100	COG0352	thiamine-phosphate diphosphorylase activity
AXY_03120	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXY_03140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXY_03150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXY_03190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_03200	COG0745	RESPONSE REGULATOR receiver
AXY_03210	COG3850	Histidine kinase
AXY_03210	COG5002	protein histidine kinase activity
AXY_03230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AXY_03240	COG0573	inorganic phosphate transmembrane transporter activity
AXY_03250	COG0581	inorganic phosphate transmembrane transporter activity
AXY_03260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXY_03270	COG0577	efflux transmembrane transporter activity
AXY_03280	COG1136	(ABC) transporter
AXY_03290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXY_03340	COG1846	Transcriptional regulator
AXY_03390	COG0513	Belongs to the DEAD box helicase family
AXY_03410	COG0705	Rhomboid family
AXY_03420	COG0736	holo-[acyl-carrier-protein] synthase activity
AXY_03430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AXY_03430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AXY_03440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AXY_03460	COG0864	Transcriptional regulator
AXY_03470	COG2337	Toxic component of a toxin-antitoxin (TA) module
AXY_03480	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_03490	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_03500	COG2172	sigma factor antagonist activity
AXY_03510	COG2208	phosphoserine phosphatase activity
AXY_03520	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_03530	COG2172	sigma factor antagonist activity
AXY_03540	COG1191	sigma factor activity
AXY_03550	COG2208	phosphoserine phosphatase activity
AXY_03560	COG2183	response to ionizing radiation
AXY_03570	COG0549	Belongs to the carbamate kinase family
AXY_03580	COG3091	SprT-like family
AXY_03590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AXY_03600	COG0802	atpase or kinase
AXY_03610	COG1214	PFAM Peptidase M22, glycoprotease
AXY_03620	COG0456	acetyltransferase
AXY_03640	COG0488	(ABC) transporter
AXY_03650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AXY_03670	COG1266	CAAX protease self-immunity
AXY_03680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXY_03690	COG0459	protein refolding
AXY_03740	COG2205	protein histidine kinase activity
AXY_03740	COG0784	Response regulator, receiver
AXY_03750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AXY_03780	COG0667	Aldo Keto reductase
AXY_03830	COG0673	inositol 2-dehydrogenase activity
AXY_03850	COG0673	inositol 2-dehydrogenase activity
AXY_03860	COG1082	Xylose isomerase domain protein TIM barrel
AXY_03870	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_03870	COG2202	Pas domain
AXY_03880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXY_03890	COG0714	Associated with various cellular activities
AXY_03900	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AXY_03910	COG1305	Transglutaminase-like
AXY_03930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXY_03930	COG0519	Catalyzes the synthesis of GMP from XMP
AXY_03940	COG0622	Phosphoesterase
AXY_03960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXY_03970	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_03980	COG1801	Protein of unknown function DUF72
AXY_04010	COG1695	Transcriptional regulator
AXY_04040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXY_04040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_04040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXY_04050	COG1105	Belongs to the carbohydrate kinase PfkB family
AXY_04060	COG1349	DNA-binding transcription factor activity
AXY_04070	COG4213	ABC transporter substrate-binding protein
AXY_04090	COG4214	carbohydrate transport
AXY_04110	COG2972	Histidine kinase
AXY_04120	COG2207	Transcriptional regulator
AXY_04120	COG4753	response regulator
AXY_04130	COG4213	ABC transporter substrate-binding protein
AXY_04140	COG0840	transmembrane signaling receptor activity
AXY_04170	COG1131	(ABC) transporter
AXY_04200	COG1063	alcohol dehydrogenase
AXY_04240	COG2252	PERMEase
AXY_04260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AXY_04270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AXY_04280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AXY_04290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXY_04300	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXY_04310	COG0047	phosphoribosylformylglycinamidine synthase activity
AXY_04320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXY_04330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AXY_04340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXY_04350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXY_04360	COG0138	bifunctional purine biosynthesis protein purh
AXY_04370	COG0151	Belongs to the GarS family
AXY_04380	COG1131	(ABC) transporter
AXY_04390	COG4555	ABC transporter
AXY_04410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXY_04430	COG1470	cell adhesion involved in biofilm formation
AXY_04440	COG4496	protein, YerC YecD
AXY_04450	COG0673	inositol 2-dehydrogenase activity
AXY_04460	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AXY_04470	COG0210	DNA helicase
AXY_04480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXY_04490	COG4851	CamS sex pheromone cAM373 precursor
AXY_04500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXY_04510	COG0154	amidase activity
AXY_04520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXY_04530	COG1597	lipid kinase activity
AXY_04540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXY_04570	COG3620	sequence-specific DNA binding
AXY_04610	COG0500	methyltransferase
AXY_04680	COG0798	PFAM Bile acid sodium symporter
AXY_04770	COG0745	RESPONSE REGULATOR receiver
AXY_04800	COG2205	protein histidine kinase activity
AXY_04890	COG0745	RESPONSE REGULATOR receiver
AXY_04900	COG0642	Histidine kinase
AXY_04910	COG1136	(ABC) transporter
AXY_04920	COG0577	efflux transmembrane transporter activity
AXY_04940	COG2801	Transposase and inactivated derivatives
AXY_04970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AXY_04980	COG1116	anion transmembrane transporter activity
AXY_04990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXY_05000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXY_05020	COG2801	Transposase and inactivated derivatives
AXY_05150	COG2207	Transcriptional regulator
AXY_05150	COG3708	Transcriptional regulator
AXY_05170	COG2205	protein histidine kinase activity
AXY_05180	COG1595	DNA-templated transcription, initiation
AXY_05190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXY_05200	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AXY_05280	COG1269	ATP hydrolysis coupled proton transport
AXY_05320	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AXY_05340	COG1394	ATPase activity, coupled to movement of substances
AXY_05360	COG0583	DNA-binding transcription factor activity
AXY_05380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXY_05400	COG1733	regulation of RNA biosynthetic process
AXY_05410	COG2514	catechol 2,3-dioxygenase activity
AXY_05430	COG2239	Acts as a magnesium transporter
AXY_05440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_05440	COG2190	(PTS) system
AXY_05440	COG1263	PTS System
AXY_05450	COG2723	6-phospho-beta-galactosidase activity
AXY_05470	COG3682	Transcriptional regulator
AXY_05480	COG2608	mercury ion transmembrane transporter activity
AXY_05500	COG1253	flavin adenine dinucleotide binding
AXY_05520	COG2801	Transposase and inactivated derivatives
AXY_05640	COG3385	transposase activity
AXY_05680	COG3250	beta-galactosidase activity
AXY_05700	COG0840	transmembrane signaling receptor activity
AXY_05720	COG2918	glutathione biosynthetic process
AXY_05770	COG1132	(ABC) transporter
AXY_05780	COG1132	(ABC) transporter
AXY_05850	COG0714	Associated with various cellular activities
AXY_05890	COG2848	UPF0210 protein
AXY_05910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AXY_05920	COG1063	alcohol dehydrogenase
AXY_05930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AXY_05940	COG0647	UMP catabolic process
AXY_05960	COG2190	(PTS) system
AXY_05970	COG1077	Cell shape determining protein MreB Mrl
AXY_06010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXY_06030	COG1295	ribonuclease BN
AXY_06040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXY_06050	COG0765	amino acid transport
AXY_06070	COG2801	Transposase and inactivated derivatives
AXY_06080	COG0477	Major facilitator Superfamily
AXY_06100	COG0668	transmembrane transport
AXY_06120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AXY_06150	COG0542	response to heat
AXY_06170	COG1131	(ABC) transporter
AXY_06190	COG5658	integral membrane protein
AXY_06200	COG0640	Transcriptional regulator
AXY_06220	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_06230	COG0840	transmembrane signaling receptor activity
AXY_06240	COG4844	belongs to the
AXY_06260	COG2137	regulation of response to DNA damage stimulus
AXY_06280	COG1988	membrane-bound metal-dependent
AXY_06290	COG1194	a g-specific adenine glycosylase
AXY_06310	COG3557	Belongs to the UPF0374 family
AXY_06320	COG4129	membrane
AXY_06340	COG2096	Adenosyltransferase
AXY_06350	COG0735	belongs to the Fur family
AXY_06470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXY_06480	COG0346	lactoylglutathione lyase activity
AXY_06510	COG0745	RESPONSE REGULATOR receiver
AXY_06520	COG2205	protein histidine kinase activity
AXY_06530	COG1136	(ABC) transporter
AXY_06540	COG0577	efflux transmembrane transporter activity
AXY_06550	COG0745	RESPONSE REGULATOR receiver
AXY_06560	COG5002	protein histidine kinase activity
AXY_06580	COG2738	Putative neutral zinc metallopeptidase
AXY_06590	COG1334	flagellar protein FlaG
AXY_06600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AXY_06610	COG1516	flagellar protein fliS
AXY_06630	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AXY_06670	COG4214	carbohydrate transport
AXY_06680	COG0653	protein targeting
AXY_06690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXY_06700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AXY_06710	COG2884	Cell division ATP-binding protein ftsE
AXY_06720	COG2177	Part of the ABC transporter FtsEX involved in
AXY_06730	COG0739	heme binding
AXY_06740	COG3409	Peptidoglycan-binding domain 1 protein
AXY_06740	COG0793	Belongs to the peptidase S41A family
AXY_06750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_06770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AXY_06780	COG0556	nucleotide-excision repair
AXY_06790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXY_06800	COG1983	PspC domain protein
AXY_06810	COG1950	PFAM Membrane protein of
AXY_06840	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AXY_06850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AXY_06860	COG0546	phosphoglycolate phosphatase activity
AXY_06870	COG0110	maltose O-acetyltransferase activity
AXY_06880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXY_06900	COG0492	ferredoxin-NADP+ reductase activity
AXY_06920	COG1486	melibiose metabolic process
AXY_06970	COG1051	belongs to the nudix hydrolase family
AXY_06980	COG1660	Displays ATPase and GTPase activities
AXY_06990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AXY_07000	COG1481	regulation of sporulation
AXY_07010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_07050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXY_07060	COG3711	transcriptional antiterminator
AXY_07070	COG2190	(PTS) system
AXY_07070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_07070	COG1263	PTS System
AXY_07190	COG2197	response regulator
AXY_07200	COG4152	abc transporter atp-binding protein
AXY_07210	COG1668	transmembrane transport
AXY_07220	COG0420	3'-5' exonuclease activity
AXY_07250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXY_07290	COG0537	adenosine 5'-monophosphoramidase activity
AXY_07300	COG1131	(ABC) transporter
AXY_07310	COG4473	ABC transporter
AXY_07330	COG4585	Histidine kinase
AXY_07340	COG2197	response regulator
AXY_07350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXY_07420	COG4133	protoheme IX ABC transporter activity
AXY_07520	COG1131	(ABC) transporter
AXY_07660	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_07670	COG1472	Belongs to the glycosyl hydrolase 3 family
AXY_07690	COG2972	Histidine kinase
AXY_07700	COG2207	Transcriptional regulator
AXY_07700	COG4753	response regulator
AXY_07730	COG4209	transmembrane transport
AXY_07740	COG0395	ABC-type sugar transport system, permease component
AXY_07770	COG1501	Belongs to the glycosyl hydrolase 31 family
AXY_07790	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_07800	COG1234	tRNA 3'-trailer cleavage
AXY_07810	COG0095	Lipoate-protein ligase
AXY_07850	COG0398	Pfam SNARE associated Golgi protein
AXY_07860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AXY_07870	COG1074	ATP-dependent DNA helicase activity
AXY_07880	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXY_07890	COG4605	iron ion homeostasis
AXY_07900	COG4604	ABC transporter, ATP-binding protein
AXY_07910	COG4607	ABC-type enterochelin transport system periplasmic component
AXY_07930	COG0835	chemotaxis
AXY_07940	COG2201	protein-glutamate methylesterase activity
AXY_07950	COG0840	transmembrane signaling receptor activity
AXY_07960	COG1960	acyl-CoA dehydrogenase activity
AXY_07980	COG0589	response to stress
AXY_07990	COG0735	belongs to the Fur family
AXY_08000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXY_08010	COG1121	(ABC) transporter
AXY_08020	COG5577	PFAM Coat F domain
AXY_08040	COG1393	Belongs to the ArsC family
AXY_08050	COG0509	glycine decarboxylation via glycine cleavage system
AXY_08060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_08070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXY_08080	COG2011	ABC-type metal ion transport system permease component
AXY_08090	COG1464	Belongs to the NlpA lipoprotein family
AXY_08100	COG0396	ATPase activity
AXY_08110	COG0719	Fe-S assembly protein
AXY_08120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AXY_08130	COG0822	iron-sulfur transferase activity
AXY_08140	COG0719	Fe-S assembly protein
AXY_08150	COG1132	(ABC) transporter
AXY_08160	COG0737	Belongs to the 5'-nucleotidase family
AXY_08270	COG0675	Transposase, IS605 OrfB family
AXY_08350	COG0733	neurotransmitter:sodium symporter activity
AXY_08370	COG0739	heme binding
AXY_08380	COG4470	Protein conserved in bacteria
AXY_08390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AXY_08400	COG0460	homoserine dehydrogenase
AXY_08410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXY_08420	COG0083	homoserine kinase activity
AXY_08430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AXY_08440	COG0316	Belongs to the HesB IscA family
AXY_08450	COG0492	ferredoxin-NADP+ reductase activity
AXY_08460	COG1252	NADH dehydrogenase
AXY_08480	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AXY_08490	COG1268	BioY protein
AXY_08500	COG0813	purine-nucleoside phosphorylase activity
AXY_08510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_08520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AXY_08530	COG1098	S1 RNA binding domain
AXY_08540	COG0166	Belongs to the GPI family
AXY_08560	COG0367	asparagine synthase
AXY_08570	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AXY_08580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXY_08610	COG0494	nUDIX hydrolase
AXY_08620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXY_08640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AXY_08650	COG0495	leucyl-tRNA aminoacylation
AXY_08670	COG1131	(ABC) transporter
AXY_08720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXY_08750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXY_08750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXY_08800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXY_08810	COG1115	amino acid carrier protein
AXY_08820	COG2081	HI0933 family
AXY_08830	COG2244	polysaccharide biosynthetic process
AXY_08840	COG1187	pseudouridine synthase activity
AXY_08850	COG1349	DNA-binding transcription factor activity
AXY_08870	COG0510	thiamine kinase activity
AXY_08890	COG1363	Peptidase, m42
AXY_08900	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AXY_08930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_08940	COG4848	Belongs to the UPF0354 family
AXY_08950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_08960	COG1674	ftsk spoiiie
AXY_08980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXY_09000	COG4980	gas vesicle protein
AXY_09020	COG0849	cell division
AXY_09030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AXY_09030	COG1605	Chorismate mutase
AXY_09080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXY_09090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXY_09100	COG2203	Gaf domain
AXY_09100	COG2199	diguanylate cyclase activity
AXY_09110	COG1956	GAF domain-containing protein
AXY_09120	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AXY_09140	COG1104	cysteine desulfurase activity
AXY_09150	COG0301	tRNA thio-modification
AXY_09180	COG3874	Sporulation protein YtfJ
AXY_09190	COG0827	DNA restriction-modification system
AXY_09200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXY_09210	COG0589	response to stress
AXY_09220	COG4109	DRTGG domain
AXY_09230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AXY_09260	COG0587	DNA-directed DNA polymerase activity
AXY_09270	COG0281	malic enzyme
AXY_09280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AXY_09300	COG0205	6-phosphofructokinase activity
AXY_09320	COG3030	protein affecting phage T7 exclusion by the F plasmid
AXY_09340	COG2707	UPF0756 membrane protein
AXY_09350	COG0372	Belongs to the citrate synthase family
AXY_09360	COG0538	isocitrate dehydrogenase activity
AXY_09370	COG0745	RESPONSE REGULATOR receiver
AXY_09380	COG5002	protein histidine kinase activity
AXY_09390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_09390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_09400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXY_09410	COG1971	Probably functions as a manganese efflux pump
AXY_09420	COG0237	dephospho-CoA kinase activity
AXY_09440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXY_09450	COG3611	Membrane attachment protein
AXY_09460	COG1484	DNA-dependent DNA replication
AXY_09480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXY_09500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXY_09510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXY_09530	COG3326	Membrane
AXY_09550	COG0756	dUTP diphosphatase activity
AXY_09560	COG1363	Peptidase, m42
AXY_09570	COG1136	(ABC) transporter
AXY_09580	COG1136	(ABC) transporter
AXY_09580	COG0577	efflux transmembrane transporter activity
AXY_09600	COG0741	lytic transglycosylase activity
AXY_09620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXY_09630	COG0791	NLP P60 protein
AXY_09630	COG1388	LysM domain
AXY_09640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXY_09650	COG0072	phenylalanine-tRNA ligase activity
AXY_09650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_09660	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXY_09670	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AXY_09680	COG1286	toxin biosynthetic process
AXY_09690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AXY_09690	COG1796	DNA polymerase
AXY_09700	COG1193	negative regulation of DNA recombination
AXY_09710	COG3118	belongs to the thioredoxin family
AXY_09720	COG0322	excinuclease ABC activity
AXY_09740	COG2197	response regulator
AXY_09780	COG2801	Transposase and inactivated derivatives
AXY_09800	COG1846	Transcriptional regulator
AXY_09810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXY_09820	COG5401	PFAM Sporulation and spore germination
AXY_09830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AXY_09840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXY_09850	COG0622	Phosphoesterase
AXY_09900	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXY_09910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXY_09950	COG1388	LysM domain
AXY_09950	COG1388	LysM domain
AXY_09970	COG0525	valine-tRNA ligase activity
AXY_09980	COG3706	GGDEF domain
AXY_09990	COG0285	dihydrofolate synthase activity
AXY_10030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXY_10070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AXY_10120	COG2003	Belongs to the UPF0758 family
AXY_10140	COG2003	Belongs to the UPF0758 family
AXY_10150	COG1077	Cell shape determining protein MreB Mrl
AXY_10160	COG1792	Involved in formation and maintenance of cell shape
AXY_10190	COG2894	cell division
AXY_10210	COG1994	Peptidase M50
AXY_10220	COG1530	ribonuclease E activity
AXY_10240	COG2868	ribosomal protein
AXY_10250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXY_10270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXY_10280	COG4492	Belongs to the UPF0735 family
AXY_10290	COG0077	Prephenate dehydratase
AXY_10300	COG1827	regulation of RNA biosynthetic process
AXY_10310	COG1388	LysM domain
AXY_10320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXY_10330	COG0217	transcriptional regulatory protein
AXY_10350	COG0632	four-way junction helicase activity
AXY_10360	COG2255	four-way junction helicase activity
AXY_10370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AXY_10390	COG1862	Preprotein translocase
AXY_10420	COG2323	membrane
AXY_10430	COG2244	polysaccharide biosynthetic process
AXY_10450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXY_10450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXY_10460	COG5416	Lipopolysaccharide assembly protein A domain
AXY_10470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AXY_10470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AXY_10480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXY_10490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXY_10500	COG1490	D-aminoacyl-tRNA deacylase activity
AXY_10510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXY_10520	COG0704	Plays a role in the regulation of phosphate uptake
AXY_10530	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_10530	COG4991	sh3 domain protein
AXY_10530	COG3103	Sh3 type 3 domain protein
AXY_10540	COG0124	histidyl-tRNA synthetase
AXY_10550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXY_10570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXY_10580	COG1959	2 iron, 2 sulfur cluster binding
AXY_10590	COG1104	cysteine desulfurase activity
AXY_10600	COG0482	sulfurtransferase activity
AXY_10650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXY_10670	COG0628	permease
AXY_10680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXY_10690	COG4472	Bacterial protein of unknown function (DUF965)
AXY_10700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXY_10710	COG3906	Belongs to the UPF0473 family
AXY_10730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXY_10750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXY_10770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AXY_10780	COG1191	sigma factor activity
AXY_10800	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AXY_10810	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AXY_10820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXY_10830	COG1534	Rna-binding protein
AXY_10840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXY_10850	COG1713	HD superfamily hydrolase involved in NAD metabolism
AXY_10860	COG0799	negative regulation of ribosome biogenesis
AXY_10870	COG2226	methyltransferase
AXY_10890	COG2131	deaminase
AXY_10900	COG0658	competence protein
AXY_10900	COG2333	competence protein COMEC
AXY_10910	COG1466	dna polymerase III delta subunit
AXY_10920	COG0268	Binds directly to 16S ribosomal RNA
AXY_10930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AXY_10940	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_10960	COG0481	GTPase activity
AXY_10970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXY_10980	COG1420	regulation of RNA biosynthetic process
AXY_11000	COG0443	Heat shock 70 kDa protein
AXY_11010	COG0484	heat shock protein binding
AXY_11020	COG2264	protein methyltransferase activity
AXY_11030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXY_11040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AXY_11050	COG1610	YqeY-like protein
AXY_11060	COG1030	water channel activity
AXY_11070	COG4864	UPF0365 protein
AXY_11110	COG1702	phosphate starvation-inducible protein PhoH
AXY_11120	COG1480	7TM receptor with intracellular HD hydrolase
AXY_11130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXY_11140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AXY_11150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXY_11160	COG1381	Involved in DNA repair and RecF pathway recombination
AXY_11170	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AXY_11180	COG0752	glycyl-tRNA synthetase alpha subunit
AXY_11190	COG0751	glycine-tRNA ligase activity
AXY_11200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AXY_11210	COG0358	DNA primase activity
AXY_11220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXY_11240	COG2384	SAM-dependent methyltransferase
AXY_11250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXY_11270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AXY_11320	COG0704	Plays a role in the regulation of phosphate uptake
AXY_11330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AXY_11340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AXY_11390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXY_11400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXY_11420	COG1940	carbohydrate kinase activity
AXY_11430	COG1368	sulfuric ester hydrolase activity
AXY_11440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXY_11490	COG4537	Required for transformation and DNA binding
AXY_11500	COG1459	type II secretion system
AXY_11510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXY_11550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AXY_11560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXY_11570	COG1321	iron dependent repressor
AXY_11580	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXY_11610	COG0006	proline dipeptidase activity
AXY_11620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXY_11630	COG3854	ATPases associated with a variety of cellular activities
AXY_11710	COG0511	ligase activity, forming carbon-carbon bonds
AXY_11720	COG0439	Biotin carboxylase
AXY_11730	COG1302	Protein conserved in bacteria
AXY_11740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXY_11750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXY_11780	COG0142	geranyltranstransferase activity
AXY_11790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AXY_11810	COG0497	DNA recombination
AXY_11820	COG0750	zinc metalloprotease
AXY_11840	COG2340	Cysteine-rich secretory protein family
AXY_11850	COG0527	aspartate kinase activity
AXY_11860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXY_11870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AXY_11880	COG0022	dehydrogenase e1 component
AXY_11890	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXY_11900	COG4129	membrane
AXY_11920	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXY_11930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXY_11940	COG1234	tRNA 3'-trailer cleavage
AXY_11950	COG0584	glycerophosphoryl diester phosphodiesterase
AXY_11960	COG0300	oxidoreductase activity
AXY_11970	COG0494	nUDIX hydrolase
AXY_11980	COG1379	DNA repair
AXY_11990	COG1300	Membrane
AXY_12000	COG0735	belongs to the Fur family
AXY_12010	COG4974	Belongs to the 'phage' integrase family
AXY_12020	COG1686	Belongs to the peptidase S11 family
AXY_12060	COG0697	spore germination
AXY_12080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXY_12090	COG0456	acetyltransferase
AXY_12100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AXY_12110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AXY_12120	COG1686	Belongs to the peptidase S11 family
AXY_12130	COG2715	membrane protein required for spore maturation
AXY_12140	COG0700	Nucleoside recognition
AXY_12150	COG1187	pseudouridine synthase activity
AXY_12160	COG0745	RESPONSE REGULATOR receiver
AXY_12170	COG5002	protein histidine kinase activity
AXY_12180	COG1595	DNA-templated transcription, initiation
AXY_12210	COG4955	Helix-turn-helix domain
AXY_12220	COG0514	ATP-dependent DNA helicase (RecQ)
AXY_12240	COG4862	establishment of competence for transformation
AXY_12250	COG3773	Cell wall hydrolase
AXY_12250	COG3409	Peptidoglycan-binding domain 1 protein
AXY_12260	COG2959	enzyme of heme biosynthesis
AXY_12270	COG3344	reverse transcriptase
AXY_12280	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AXY_12310	COG0539	negative regulation of cytoplasmic translation
AXY_12330	COG1160	GTP binding
AXY_12340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXY_12360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AXY_12370	COG0776	regulation of translation
AXY_12400	COG0142	geranyltranstransferase activity
AXY_12410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AXY_12430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXY_12440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXY_12450	COG4401	Chorismate mutase type I
AXY_12460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXY_12470	COG0287	Prephenate dehydrogenase
AXY_12480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXY_12510	COG0457	Tetratricopeptide repeat
AXY_12520	COG5582	Belongs to the UPF0302 family
AXY_12530	COG4347	Protein of unknown function (DUF1405)
AXY_12550	COG1694	Mazg nucleotide pyrophosphohydrolase
AXY_12560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXY_12570	COG1803	Methylglyoxal synthase
AXY_12580	COG0617	tRNA 3'-terminal CCA addition
AXY_12590	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AXY_12590	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AXY_12610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXY_12620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXY_12630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXY_12630	COG1199	ATP-dependent helicase activity
AXY_12650	COG0436	Aminotransferase
AXY_12660	COG0017	Asparaginyl-tRNA synthetase
AXY_12670	COG3935	DnaD domain protein
AXY_12680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXY_12690	COG4499	WXG100 protein secretion system (Wss), protein YukC
AXY_12690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXY_12700	COG3331	DNA recombination
AXY_12740	COG4474	Belongs to the UPF0398 family
AXY_12750	COG3599	regulation of cell shape
AXY_12760	COG0116	Belongs to the methyltransferase superfamily
AXY_12770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AXY_12790	COG0328	RNA-DNA hybrid ribonuclease activity
AXY_12800	COG1278	Cold shock
AXY_12810	COG0791	NLP P60 protein
AXY_12810	COG1388	LysM domain
AXY_12820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXY_12830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXY_12850	COG0420	3'-5' exonuclease activity
AXY_12860	COG0419	ATPase involved in DNA repair
AXY_12890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXY_12890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXY_12930	COG1254	Belongs to the acylphosphatase family
AXY_12940	COG5646	InterPro IPR014922
AXY_13010	COG0346	lactoylglutathione lyase activity
AXY_13020	COG1307	EDD domain protein, DegV family
AXY_13050	COG0723	plastoquinol--plastocyanin reductase activity
AXY_13050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXY_13080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXY_13090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXY_13110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AXY_13120	COG0628	permease
AXY_13130	COG2814	Major facilitator Superfamily
AXY_13150	COG3425	synthase
AXY_13170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AXY_13190	COG2059	Chromate
AXY_13210	COG0326	Molecular chaperone. Has ATPase activity
AXY_13230	COG1394	ATPase activity, coupled to movement of substances
AXY_13240	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AXY_13250	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AXY_13260	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AXY_13270	COG1527	subunit (C
AXY_13290	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXY_13300	COG1269	ATP hydrolysis coupled proton transport
AXY_13320	COG2996	Protein conserved in bacteria
AXY_13340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXY_13350	COG1227	inorganic diphosphatase activity
AXY_13370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXY_13380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXY_13390	COG0583	DNA-binding transcription factor activity
AXY_13400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXY_13410	COG0140	phosphoribosyl-ATP diphosphatase activity
AXY_13410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXY_13420	COG0107	imidazoleglycerol-phosphate synthase activity
AXY_13440	COG0131	Imidazoleglycerol-phosphate dehydratase
AXY_13450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXY_13470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AXY_13480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AXY_13500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXY_13510	COG0187	DNA topoisomerase II activity
AXY_13520	COG1832	CoA-binding protein
AXY_13530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AXY_13540	COG1469	GTP cyclohydrolase I activity
AXY_13580	COG0824	Thioesterase
AXY_13590	COG0464	growth
AXY_13600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXY_13610	COG4191	Histidine kinase
AXY_13620	COG3763	UPF0154 protein
AXY_13650	COG4224	UPF0291 protein
AXY_13670	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_13680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXY_13690	COG0840	transmembrane signaling receptor activity
AXY_13710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AXY_13720	COG0531	amino acid
AXY_13770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXY_13800	COG2824	Alkylphosphonate utilization operon protein PhnA
AXY_13810	COG0500	methyltransferase
AXY_13910	COG3316	Transposase and inactivated derivatives
AXY_13930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_13930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_14080	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_14130	COG2207	Transcriptional regulator
AXY_14140	COG1486	melibiose metabolic process
AXY_14160	COG1064	alcohol dehydrogenase
AXY_14200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXY_14220	COG0464	growth
AXY_14240	COG1923	regulation of RNA biosynthetic process
AXY_14250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXY_14260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXY_14270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AXY_14300	COG4550	Control of competence regulator ComK, YlbF/YmcA
AXY_14320	COG2359	stage V sporulation protein S
AXY_14330	COG1692	metallophosphoesterase
AXY_14340	COG1418	mRNA catabolic process
AXY_14350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXY_14360	COG1058	Belongs to the CinA family
AXY_14360	COG1546	Belongs to the CinA family
AXY_14370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXY_14380	COG1426	Protein conserved in bacteria
AXY_14390	COG0612	Peptidase, M16
AXY_14400	COG0612	Peptidase, M16
AXY_14410	COG2188	Transcriptional regulator
AXY_14440	COG1674	ftsk spoiiie
AXY_14450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXY_14460	COG0527	aspartate kinase activity
AXY_14470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AXY_14480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXY_14490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXY_14500	COG1873	PFAM PRC-barrel domain
AXY_14520	COG1185	polyribonucleotide nucleotidyltransferase activity
AXY_14530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXY_14540	COG0196	riboflavin kinase activity
AXY_14550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXY_14560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXY_14570	COG1550	Protein conserved in bacteria
AXY_14580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXY_14590	COG1358	cellular component organization or biogenesis
AXY_14600	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AXY_14610	COG0195	Participates in both transcription termination and antitermination
AXY_14620	COG0779	Required for maturation of 30S ribosomal subunits
AXY_14630	COG2176	DNA-directed DNA polymerase activity
AXY_14640	COG0442	prolyl-tRNA aminoacylation
AXY_14650	COG0750	zinc metalloprotease
AXY_14660	COG4589	Belongs to the CDS family
AXY_14670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXY_14680	COG0233	cytoplasmic translational termination
AXY_14690	COG0528	UMP kinase activity
AXY_14700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXY_14710	COG0052	Belongs to the universal ribosomal protein uS2 family
AXY_14750	COG1191	sigma factor activity
AXY_14760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AXY_14770	COG1776	CheC inhibitor of MCP methylation
AXY_14780	COG0835	chemotaxis
AXY_14790	COG2198	Histidine kinase
AXY_14790	COG0643	Histidine kinase
AXY_14800	COG2201	protein-glutamate methylesterase activity
AXY_14810	COG0455	bacterial-type flagellum organization
AXY_14820	COG1419	protein localization to endoplasmic reticulum
AXY_14830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXY_14840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXY_14850	COG1684	flagellar biosynthetic protein fliR
AXY_14860	COG1987	bacterial-type flagellum assembly
AXY_14870	COG1338	Plays a role in the flagellum-specific transport system
AXY_14880	COG3190	flagellar
AXY_14890	COG2201	protein-glutamate methylesterase activity
AXY_14900	COG1776	CheC inhibitor of MCP methylation
AXY_14900	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXY_14910	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXY_14930	COG1582	Flagellar protein (FlbD)
AXY_14940	COG4786	Flagellar basal body rod
AXY_14960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AXY_15020	COG1157	protein secretion by the type III secretion system
AXY_15040	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXY_15050	COG1766	The M ring may be actively involved in energy transduction
AXY_15060	COG1677	Flagellar hook-basal body complex protein FliE
AXY_15070	COG1558	bacterial-type flagellum-dependent cell motility
AXY_15080	COG1815	bacterial-type flagellum-dependent cell motility
AXY_15090	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AXY_15100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AXY_15110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AXY_15120	COG4974	Belongs to the 'phage' integrase family
AXY_15130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXY_15140	COG0758	DNA mediated transformation
AXY_15150	COG2257	FlhB HrpN YscU SpaS Family
AXY_15170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXY_15180	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AXY_15200	COG0335	large ribosomal subunit rRNA binding
AXY_15210	COG0336	Belongs to the RNA methyltransferase TrmD family
AXY_15220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXY_15230	COG1837	Belongs to the UPF0109 family
AXY_15240	COG0228	four-way junction DNA binding
AXY_15250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXY_15260	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AXY_15270	COG0552	protein localization to endoplasmic reticulum
AXY_15280	COG1196	nuclear chromosome segregation
AXY_15290	COG4840	Belongs to the UPF0435 family
AXY_15300	COG0571	ribonuclease III activity
AXY_15310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXY_15320	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_15330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXY_15340	COG0416	fatty acid biosynthetic process
AXY_15350	COG1349	DNA-binding transcription factor activity
AXY_15360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXY_15370	COG1461	Dihydroxyacetone kinase
AXY_15380	COG1302	Protein conserved in bacteria
AXY_15390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXY_15400	COG1564	THIamine pyrophosphokinase
AXY_15410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXY_15420	COG1162	GTPase activity
AXY_15430	COG2815	serine threonine protein kinase
AXY_15430	COG0515	serine threonine protein kinase
AXY_15440	COG0631	protein serine/threonine phosphatase activity
AXY_15450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXY_15450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXY_15460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXY_15470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXY_15480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXY_15490	COG1758	RNA polymerase activity
AXY_15500	COG0194	GDP metabolic process
AXY_15510	COG2052	Domain of unknown function (DUF370)
AXY_15520	COG1561	YicC-like family, N-terminal region
AXY_15530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AXY_15580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXY_15600	COG0167	dihydroorotate dehydrogenase activity
AXY_15610	COG0543	2 iron, 2 sulfur cluster binding
AXY_15620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXY_15650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AXY_15660	COG0564	pseudouridine synthase activity
AXY_15680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXY_15690	COG3599	regulation of cell shape
AXY_15700	COG2302	S4 RNA-binding domain
AXY_15710	COG0762	integral membrane protein
AXY_15720	COG1799	cell septum assembly
AXY_15730	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXY_15760	COG1191	sigma factor activity
AXY_15770	COG1191	sigma factor activity
AXY_15790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AXY_15800	COG0849	cell division
AXY_15810	COG3856	small basic protein
AXY_15820	COG3879	Bacterial protein of unknown function (DUF881)
AXY_15830	COG3879	Bacterial protein of unknown function (DUF881)
AXY_15840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AXY_15860	COG1136	(ABC) transporter
AXY_15870	COG0772	Belongs to the SEDS family
AXY_15880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXY_15890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXY_15900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXY_15920	COG0768	penicillin binding
AXY_15940	COG4839	cell division protein FtsL
AXY_15950	COG0275	rRNA processing
AXY_15960	COG2001	Belongs to the MraZ family
AXY_15990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXY_16000	COG1399	metal-binding, possibly nucleic acid-binding protein
AXY_16010	COG1323	Belongs to the UPF0348 family
AXY_16020	COG3480	Lon protease (S16) C-terminal proteolytic domain
AXY_16030	COG3314	Sporulation integral membrane protein YlbJ
AXY_16040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXY_16050	COG0742	ribosomal rna small subunit methyltransferase
AXY_16060	COG4471	UPF0298 protein
AXY_16070	COG3679	Belongs to the UPF0342 family
AXY_16090	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AXY_16110	COG4838	Belongs to the UPF0358 family
AXY_16130	COG4896	Protein conserved in bacteria
AXY_16140	COG0483	inositol monophosphate 1-phosphatase activity
AXY_16150	COG4476	Belongs to the UPF0223 family
AXY_16160	COG0726	polysaccharide deacetylase
AXY_16220	COG0242	peptide deformylase activity
AXY_16240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AXY_16250	COG0569	domain protein
AXY_16260	COG1132	(ABC) transporter
AXY_16270	COG1132	(ABC) transporter
AXY_16280	COG0668	transmembrane transport
AXY_16290	COG0517	IMP dehydrogenase activity
AXY_16340	COG0681	Belongs to the peptidase S26 family
AXY_16360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_16410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXY_16450	COG0028	Belongs to the TPP enzyme family
AXY_16460	COG0440	acetolactate synthase activity
AXY_16470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXY_16480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXY_16490	COG0473	3-isopropylmalate dehydrogenase activity
AXY_16500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXY_16510	COG0066	3-isopropylmalate dehydratase activity
AXY_16530	COG2706	6-phosphogluconolactonase activity
AXY_16540	COG1595	DNA-templated transcription, initiation
AXY_16560	COG1131	(ABC) transporter
AXY_16570	COG1725	Transcriptional regulator
AXY_16580	COG0400	carboxylic ester hydrolase activity
AXY_16610	COG0714	Associated with various cellular activities
AXY_16630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AXY_16680	COG1126	abc transporter atp-binding protein
AXY_16690	COG0765	amino acid transport
AXY_16700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXY_16710	COG0561	phosphatase activity
AXY_16760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXY_16770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXY_16780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXY_16790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXY_16800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXY_16810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXY_16830	COG0356	it plays a direct role in the translocation of protons across the membrane
AXY_16870	COG1278	Cold shock
AXY_16890	COG5002	protein histidine kinase activity
AXY_16890	COG3850	Histidine kinase
AXY_16900	COG0745	RESPONSE REGULATOR receiver
AXY_16950	COG0561	phosphatase activity
AXY_16960	COG0561	phosphatase activity
AXY_16980	COG2201	protein-glutamate methylesterase activity
AXY_16990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXY_17000	COG1554	hydrolase, family 65, central catalytic
AXY_17020	COG0783	Belongs to the Dps family
AXY_17030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_17040	COG0785	Cytochrome C biogenesis protein
AXY_17050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_17100	COG0516	GMP reductase activity
AXY_17140	COG1408	metallophosphoesterase
AXY_17170	COG1363	Peptidase, m42
AXY_17190	COG4555	ABC transporter
AXY_17200	COG0166	Belongs to the GPI family
AXY_17210	COG0564	pseudouridine synthase activity
AXY_17260	COG1476	TRANSCRIPTIONal
AXY_17270	COG3711	transcriptional antiterminator
AXY_17280	COG1263	PTS System
AXY_17280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_17280	COG2190	(PTS) system
AXY_17290	COG2723	6-phospho-beta-galactosidase activity
AXY_17310	COG3693	PFAM glycoside hydrolase, family 10
AXY_17320	COG3693	PFAM glycoside hydrolase, family 10
AXY_17340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_17350	COG0366	Alpha amylase catalytic
AXY_17360	COG1523	belongs to the glycosyl hydrolase 13 family
AXY_17370	COG1523	belongs to the glycosyl hydrolase 13 family
AXY_17380	COG0366	Alpha amylase catalytic
AXY_17390	COG2203	Gaf domain
AXY_17390	COG2199	diguanylate cyclase activity
AXY_17410	COG3833	ABC-type maltose transport systems, permease component
AXY_17420	COG1175	transmembrane transport
AXY_17430	COG2182	Extracellular solute-binding protein
AXY_17450	COG1609	Transcriptional regulator
AXY_17470	COG1132	(ABC) transporter
AXY_17480	COG1132	(ABC) transporter
AXY_17500	COG0129	dihydroxy-acid dehydratase activity
AXY_17510	COG3300	MHYT domain
AXY_17510	COG5001	Diguanylate cyclase
AXY_17530	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_17540	COG0534	Mate efflux family protein
AXY_17570	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_17630	COG1132	(ABC) transporter
AXY_17640	COG0534	Mate efflux family protein
AXY_17650	COG0697	spore germination
AXY_17690	COG0772	Belongs to the SEDS family
AXY_17710	COG2153	protein acetylation
AXY_17720	COG2323	membrane
AXY_17780	COG2239	Acts as a magnesium transporter
AXY_17800	COG0564	pseudouridine synthase activity
AXY_17810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXY_17820	COG2357	RelA SpoT domain protein
AXY_17830	COG4116	CYTH
AXY_17860	COG2814	Major facilitator Superfamily
AXY_17870	COG1164	Oligoendopeptidase f
AXY_17900	COG1393	Belongs to the ArsC family
AXY_17940	COG0601	transmembrane transport
AXY_17950	COG4608	Belongs to the ABC transporter superfamily
AXY_17980	COG4841	protein insertion into membrane
AXY_17990	COG0180	Tryptophanyl-tRNA synthetase
AXY_18030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXY_18040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXY_18080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXY_18090	COG2151	metal-sulfur cluster biosynthetic enzyme
AXY_18100	COG1073	alpha beta
AXY_18110	COG0561	phosphatase activity
AXY_18130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AXY_18140	COG1307	EDD domain protein, DegV family
AXY_18160	COG3883	PFAM NLP P60 protein
AXY_18160	COG0791	NLP P60 protein
AXY_18160	COG0791	NLP P60 protein
AXY_18160	COG3883	PFAM NLP P60 protein
AXY_18170	COG0710	3-dehydroquinate dehydratase activity
AXY_18180	COG1621	beta-fructofuranosidase activity
AXY_18190	COG1263	PTS System
AXY_18190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_18220	COG0745	RESPONSE REGULATOR receiver
AXY_18220	COG2972	Histidine kinase
AXY_18230	COG3279	Response regulator of the LytR AlgR family
AXY_18250	COG0557	exoribonuclease II activity
AXY_18270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXY_18280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_18290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXY_18340	COG0148	phosphopyruvate hydratase activity
AXY_18350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AXY_18360	COG0149	triose-phosphate isomerase activity
AXY_18370	COG0126	phosphoglycerate kinase activity
AXY_18410	COG0740	serine-type endopeptidase activity
AXY_18420	COG3679	Belongs to the UPF0342 family
AXY_18440	COG2508	Transcriptional regulator
AXY_18450	COG3842	ATPase activity
AXY_18470	COG0114	fumarate hydratase activity
AXY_18480	COG1876	peptidase activity
AXY_18490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AXY_18520	COG0024	Methionine aminopeptidase
AXY_18540	COG1917	Cupin 2, conserved barrel domain protein
AXY_18540	COG2207	Transcriptional regulator
AXY_18590	COG1937	Protein conserved in bacteria
AXY_18620	COG1854	S-ribosylhomocysteine lyase activity
AXY_18650	COG0288	reversible hydration of carbon dioxide
AXY_18660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXY_18680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXY_18700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AXY_18710	COG1842	Phage shock protein A
AXY_18720	COG1842	Phage shock protein A
AXY_18770	COG5001	Diguanylate cyclase
AXY_18770	COG5002	protein histidine kinase activity
AXY_18770	COG3447	MASE1 domain protein
AXY_18780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AXY_18800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXY_18880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXY_18890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AXY_18900	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AXY_18920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXY_18930	COG4786	Flagellar basal body rod
AXY_18930	COG1256	bacterial-type flagellum assembly
AXY_18970	COG1040	competence protein
AXY_18980	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AXY_18990	COG1307	EDD domain protein, DegV family
AXY_19000	COG2197	response regulator
AXY_19010	COG4585	Histidine kinase
AXY_19020	COG5578	integral membrane protein
AXY_19030	COG0395	ABC-type sugar transport system, permease component
AXY_19040	COG1175	transmembrane transport
AXY_19050	COG1653	transport
AXY_19060	COG2207	Transcriptional regulator
AXY_19070	COG2972	Histidine kinase
AXY_19080	COG1739	Uncharacterized protein family UPF0029
AXY_19090	COG3764	Sortase (surface protein transpeptidase)
AXY_19100	COG0768	penicillin binding
AXY_19300	COG0667	Aldo Keto reductase
AXY_19310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXY_19320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AXY_19330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXY_19340	COG1874	Beta-galactosidase
AXY_19350	COG0662	Cupin 2, conserved barrel domain protein
AXY_19350	COG2207	Transcriptional regulator
AXY_19360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXY_19380	COG2357	RelA SpoT domain protein
AXY_19390	COG1272	protein, Hemolysin III
AXY_19400	COG1316	TRANSCRIPTIONal
AXY_19470	COG0840	transmembrane signaling receptor activity
AXY_19490	COG0205	6-phosphofructokinase activity
AXY_19520	COG1879	ABC-type sugar transport system periplasmic component
AXY_19530	COG1172	Belongs to the binding-protein-dependent transport system permease family
AXY_19540	COG1129	ABC transporter
AXY_19550	COG1869	D-ribose catabolic process
AXY_19560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXY_19570	COG1609	Transcriptional regulator
AXY_19610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXY_19630	COG2267	carboxylic ester hydrolase activity
AXY_19640	COG0534	Mate efflux family protein
AXY_19650	COG0840	transmembrane signaling receptor activity
AXY_19660	COG0667	Aldo Keto reductase
AXY_19690	COG1132	(ABC) transporter
AXY_19700	COG1132	(ABC) transporter
AXY_19800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXY_19820	COG1942	4-Oxalocrotonate Tautomerase
AXY_19830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXY_19840	COG0626	cystathionine gamma-synthase activity
AXY_19950	COG3192	ethanolamine utilization protein
AXY_19970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXY_19980	COG0583	DNA-binding transcription factor activity
AXY_20030	COG0438	transferase activity, transferring glycosyl groups
AXY_20050	COG0438	transferase activity, transferring glycosyl groups
AXY_20080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXY_20100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AXY_20110	COG4464	protein tyrosine phosphatase activity
AXY_20120	COG3859	Proton-coupled thiamine transporter YuaJ
AXY_20130	COG0489	protein tyrosine kinase activity
AXY_20140	COG3944	biosynthesis protein
AXY_20150	COG2200	EAL domain
AXY_20180	COG1316	TRANSCRIPTIONal
AXY_20190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXY_20210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_20230	COG1682	transport, permease protein
AXY_20250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_20260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_20280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXY_20290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_20300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXY_20330	COG0438	transferase activity, transferring glycosyl groups
AXY_20360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXY_20380	COG4786	Flagellar basal body rod
AXY_20390	COG4786	Flagellar basal body rod
AXY_20400	COG1077	Cell shape determining protein MreB Mrl
AXY_20410	COG1609	Transcriptional regulator
AXY_20440	COG0739	heme binding
AXY_20450	COG2385	sporulation resulting in formation of a cellular spore
AXY_20460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXY_20480	COG4836	Membrane
AXY_20490	COG1404	Belongs to the peptidase S8 family
AXY_20510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXY_20520	COG0698	ribose 5-phosphate isomerase
AXY_20530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXY_20540	COG1971	Probably functions as a manganese efflux pump
AXY_20550	COG0009	L-threonylcarbamoyladenylate synthase
AXY_20580	COG2890	protein-(glutamine-N5) methyltransferase activity
AXY_20590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXY_20600	COG1435	thymidine kinase activity
AXY_20610	COG0254	rRNA binding
AXY_20630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AXY_20640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXY_20650	COG0191	fructose-bisphosphate aldolase activity
AXY_20660	COG2204	response regulator
AXY_20670	COG0504	CTP synthase activity
AXY_20680	COG3343	RNA polymerase activity
AXY_20710	COG0018	arginyl-trna synthetase
AXY_20730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXY_20740	COG3465	dGTPase activity
AXY_20750	COG1078	dGTPase activity
AXY_20760	COG0095	Lipoate-protein ligase
AXY_20770	COG0280	phosphate acetyltransferase
AXY_20780	COG3773	Cell wall hydrolase
AXY_20800	COG2801	Transposase and inactivated derivatives
AXY_20830	COG0628	permease
AXY_20840	COG0514	ATP-dependent DNA helicase (RecQ)
AXY_20870	COG0488	(ABC) transporter
AXY_20880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXY_20910	COG2755	lipolytic protein G-D-S-L family
AXY_20950	COG2197	response regulator
AXY_20990	COG1970	mechanosensitive ion channel activity
AXY_21030	COG0488	(ABC) transporter
AXY_21040	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXY_21060	COG0159	tryptophan synthase activity
AXY_21080	COG0135	phosphoribosylanthranilate isomerase activity
AXY_21100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXY_21110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXY_21130	COG3584	3D domain protein
AXY_21130	COG1388	LysM domain
AXY_21150	COG0840	transmembrane signaling receptor activity
AXY_21170	COG5578	integral membrane protein
AXY_21180	COG0395	ABC-type sugar transport system, permease component
AXY_21190	COG1175	transmembrane transport
AXY_21220	COG2723	6-phospho-beta-galactosidase activity
AXY_21230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXY_21240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXY_21250	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AXY_21270	COG1660	Displays ATPase and GTPase activities
AXY_21290	COG1940	carbohydrate kinase activity
AXY_21330	COG0561	phosphatase activity
AXY_21350	COG0346	lactoylglutathione lyase activity
AXY_21370	COG2217	Heavy metal translocating P-type atpase
AXY_21410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AXY_21420	COG0363	glucosamine-6-phosphate deaminase activity
AXY_21440	COG3973	AAA domain
AXY_21450	COG0251	oxidation-reduction process
AXY_21460	COG0432	Pfam Uncharacterised protein family UPF0047
AXY_21470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXY_21500	COG1609	Transcriptional regulator
AXY_21530	COG0604	alcohol dehydrogenase
AXY_21550	COG0640	Transcriptional regulator
AXY_21570	COG2217	Heavy metal translocating P-type atpase
AXY_21580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXY_21590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXY_21600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AXY_21610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXY_21640	COG2966	Psort location CytoplasmicMembrane, score
AXY_21680	COG2226	methyltransferase
AXY_21720	COG1272	protein, Hemolysin III
AXY_21800	COG3458	cephalosporin-C deacetylase activity
AXY_21810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_21820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_21830	COG1447	Phosphotransferase system cellobiose-specific component IIA
AXY_21840	COG2723	6-phospho-beta-galactosidase activity
AXY_21850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_21850	COG3711	transcriptional antiterminator
AXY_21860	COG1482	cell wall glycoprotein biosynthetic process
AXY_21880	COG1131	(ABC) transporter
AXY_21910	COG2188	Transcriptional regulator
AXY_21920	COG0366	Alpha amylase catalytic
AXY_21930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_21930	COG1263	PTS System
AXY_21940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXY_21950	COG2217	Heavy metal translocating P-type atpase
AXY_21960	COG0739	heme binding
AXY_21980	COG4086	secreted protein
AXY_21990	COG0110	maltose O-acetyltransferase activity
AXY_22000	COG0450	alkyl hydroperoxide reductase
AXY_22020	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_22080	COG0157	Belongs to the NadC ModD family
AXY_22100	COG1253	flavin adenine dinucleotide binding
AXY_22110	COG0534	Mate efflux family protein
AXY_22120	COG2032	superoxide dismutase activity
AXY_22130	COG0840	transmembrane signaling receptor activity
AXY_22140	COG0656	L-ascorbic acid biosynthetic process
AXY_22180	COG2155	Conserved Protein
AXY_22190	COG1902	pentaerythritol trinitrate reductase activity
AXY_22210	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_22250	COG0561	phosphatase activity
AXY_22270	COG2801	Transposase and inactivated derivatives
AXY_22300	COG3316	Transposase and inactivated derivatives
AXY_22330	COG1132	(ABC) transporter
AXY_22340	COG3458	cephalosporin-C deacetylase activity
AXY_22350	COG0667	Aldo Keto reductase
AXY_22380	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AXY_22390	COG3833	ABC-type maltose transport systems, permease component
AXY_22400	COG1175	transmembrane transport
AXY_22420	COG3385	transposase activity
AXY_22450	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AXY_22460	COG2942	2-epimerase
AXY_22470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_22480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_22490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_22500	COG1447	Phosphotransferase system cellobiose-specific component IIA
AXY_22510	COG2723	6-phospho-beta-galactosidase activity
AXY_22520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_22520	COG3711	transcriptional antiterminator
AXY_22540	COG1482	cell wall glycoprotein biosynthetic process
AXY_22580	COG2723	6-phospho-beta-galactosidase activity
AXY_22590	COG0840	transmembrane signaling receptor activity
AXY_22620	COG0656	L-ascorbic acid biosynthetic process
AXY_22630	COG1940	carbohydrate kinase activity
AXY_22670	COG2801	Transposase and inactivated derivatives
AXY_22690	COG0726	polysaccharide deacetylase
AXY_22740	COG1216	Glycosyl transferase, family 2
AXY_22760	COG3250	beta-galactosidase activity
AXY_22800	COG3279	Response regulator of the LytR AlgR family
AXY_22810	COG0840	transmembrane signaling receptor activity
AXY_22820	COG1216	Glycosyl transferase, family 2
AXY_22880	COG1472	Belongs to the glycosyl hydrolase 3 family
AXY_22910	COG0562	UDP-galactopyranose mutase
AXY_22960	COG1464	Belongs to the NlpA lipoprotein family
AXY_22970	COG2011	ABC-type metal ion transport system permease component
AXY_22980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXY_23020	COG0726	polysaccharide deacetylase
AXY_23030	COG0564	pseudouridine synthase activity
AXY_23060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXY_23070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AXY_23110	COG1584	GPR1 FUN34 yaaH family protein
AXY_23120	COG1902	pentaerythritol trinitrate reductase activity
AXY_23130	COG2186	Transcriptional regulator
AXY_23140	COG0129	dihydroxy-acid dehydratase activity
AXY_23180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXY_23180	COG1328	CTP reductase activity
AXY_23230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AXY_23240	COG1177	transmembrane transport
AXY_23250	COG1176	ABC-type spermidine putrescine transport system, permease component I
AXY_23260	COG3842	ATPase activity
AXY_23270	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXY_23290	COG1132	(ABC) transporter
AXY_23300	COG1132	(ABC) transporter
AXY_23310	COG0625	glutathione transferase activity
AXY_23320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXY_23330	COG1215	transferase activity, transferring glycosyl groups
AXY_23340	COG5298	Protein conserved in bacteria
AXY_23360	COG0659	secondary active sulfate transmembrane transporter activity
AXY_23370	COG0840	transmembrane signaling receptor activity
AXY_23380	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXY_23410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXY_23420	COG3655	Transcriptional regulator
AXY_23440	COG0346	lactoylglutathione lyase activity
AXY_23560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXY_23570	COG0515	serine threonine protein kinase
AXY_23570	COG2815	serine threonine protein kinase
AXY_23580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AXY_23590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AXY_23630	COG1253	flavin adenine dinucleotide binding
AXY_23650	COG4720	Psort location CytoplasmicMembrane, score
AXY_23670	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AXY_23750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_23760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AXY_23770	COG4853	Protein conserved in bacteria
AXY_23780	COG4863	YycH protein
AXY_23790	COG5002	protein histidine kinase activity
AXY_23800	COG0745	RESPONSE REGULATOR receiver
AXY_23820	COG0741	lytic transglycosylase activity
AXY_23820	COG1196	nuclear chromosome segregation
AXY_23820	COG0739	heme binding
AXY_23840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXY_23850	COG0305	Participates in initiation and elongation during chromosome replication
AXY_23860	COG0359	binds to the 23S rRNA
AXY_23870	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AXY_23880	COG4241	membrane
AXY_23900	COG0584	glycerophosphoryl diester phosphodiesterase
AXY_23910	COG0534	Mate efflux family protein
AXY_23920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXY_23930	COG4658	electron transport chain
AXY_23940	COG4656	Part of a membrane complex involved in electron transport
AXY_23950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXY_23970	COG0360	Binds together with S18 to 16S ribosomal RNA
AXY_23980	COG0012	GTP binding
AXY_23990	COG4481	Protein conserved in bacteria
AXY_24000	COG3949	Membrane
AXY_24020	COG1475	DNA binding
AXY_24030	COG1192	Involved in chromosome partitioning
AXY_24040	COG1475	DNA binding
AXY_24050	COG0357	Ribosomal RNA small subunit methyltransferase G
AXY_24060	COG0445	tRNA wobble uridine modification
AXY_24070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AXY_24080	COG1847	R3H domain protein
AXY_24090	COG0706	membrane insertase activity
AXY_24100	COG0594	ribonuclease P activity
AXY_24110	COG0230	Belongs to the bacterial ribosomal protein bL34 family