locus-tag	class	description
LWP59_00010	COG0592	DNA-directed DNA polymerase activity
LWP59_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LWP59_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LWP59_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LWP59_00030	COG0187	DNA topoisomerase II activity
LWP59_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LWP59_00065	COG2318	DinB family
LWP59_00115	COG3764	Sortase (surface protein transpeptidase)
LWP59_00145	COG2815	serine threonine protein kinase
LWP59_00145	COG0515	serine threonine protein kinase
LWP59_00150	COG0515	serine threonine protein kinase
LWP59_00155	COG0768	penicillin binding
LWP59_00170	COG1716	ATPase activity
LWP59_00175	COG1716	ATPase activity
LWP59_00185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LWP59_00190	COG0583	DNA-binding transcription factor activity
LWP59_00205	COG0747	negative chemotaxis
LWP59_00215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWP59_00230	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_00235	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_00240	COG0154	amidase activity
LWP59_00255	COG2301	Belongs to the HpcH HpaI aldolase family
LWP59_00290	COG2211	Major facilitator Superfamily
LWP59_00335	COG1174	glycine betaine transport
LWP59_00345	COG1174	glycine betaine transport
LWP59_00370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LWP59_00395	COG4585	Histidine kinase
LWP59_00400	COG2197	response regulator
LWP59_00410	COG0438	transferase activity, transferring glycosyl groups
LWP59_00440	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWP59_00445	COG0022	dehydrogenase e1 component
LWP59_00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWP59_00465	COG0765	amino acid transport
LWP59_00470	COG1126	abc transporter atp-binding protein
LWP59_00505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LWP59_00510	COG3275	phosphorelay sensor kinase activity
LWP59_00520	COG3279	Response regulator of the LytR AlgR family
LWP59_00530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_00540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_00545	COG0425	Belongs to the sulfur carrier protein TusA family
LWP59_00545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWP59_00570	COG1191	sigma factor activity
LWP59_00625	COG1271	oxidase subunit
LWP59_00630	COG1294	oxidase, subunit
LWP59_00635	COG4988	ABC transporter
LWP59_00670	COG1846	Transcriptional regulator
LWP59_00690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LWP59_00710	COG4715	Zinc finger, swim domain protein
LWP59_00730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LWP59_00740	COG0406	alpha-ribazole phosphatase activity
LWP59_00770	COG0754	glutathionylspermidine amidase activity
LWP59_00775	COG3766	membrane
LWP59_00780	COG0596	Alpha beta hydrolase
LWP59_00790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LWP59_00805	COG0579	oxidoreductase
LWP59_00810	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_00825	COG0561	phosphatase activity
LWP59_00830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_00845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LWP59_00900	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_00905	COG0277	FAD linked oxidase domain protein
LWP59_00915	COG1216	Glycosyl transferase, family 2
LWP59_00945	COG1216	Glycosyl transferase, family 2
LWP59_00960	COG1216	Glycosyl transferase, family 2
LWP59_00970	COG2089	acid synthase
LWP59_00995	COG0604	alcohol dehydrogenase
LWP59_00995	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_00995	COG3321	synthase
LWP59_01030	COG2188	Transcriptional regulator
LWP59_01105	COG2329	Antibiotic biosynthesis monooxygenase
LWP59_01120	COG1522	sequence-specific DNA binding
LWP59_01140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LWP59_01170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWP59_01180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWP59_01235	COG2197	response regulator
LWP59_01265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LWP59_01270	COG1937	Protein conserved in bacteria
LWP59_01275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LWP59_01290	COG0701	Predicted permease
LWP59_01300	COG1414	Transcriptional regulator
LWP59_01310	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_01315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWP59_01320	COG0028	Belongs to the TPP enzyme family
LWP59_01325	COG0248	Ppx GppA phosphatase
LWP59_01355	COG1309	transcriptional regulator
LWP59_01385	COG3559	Exporter of polyketide antibiotics
LWP59_01390	COG1131	(ABC) transporter
LWP59_01440	COG0726	polysaccharide deacetylase
LWP59_01455	COG0287	Prephenate dehydrogenase
LWP59_01460	COG1473	amidohydrolase
LWP59_01470	COG0590	tRNA wobble adenosine to inosine editing
LWP59_01500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LWP59_01505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWP59_01520	COG1674	ftsk spoiiie
LWP59_01545	COG1234	tRNA 3'-trailer cleavage
LWP59_01570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LWP59_01575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LWP59_01580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LWP59_01585	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LWP59_01620	COG0601	transmembrane transport
LWP59_01630	COG0444	Belongs to the ABC transporter superfamily
LWP59_01635	COG4608	Belongs to the ABC transporter superfamily
LWP59_01655	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LWP59_01660	COG1414	Transcriptional regulator
LWP59_01665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LWP59_01680	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWP59_01685	COG0277	FAD linked oxidase domain protein
LWP59_01690	COG0247	lactate metabolic process
LWP59_01695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LWP59_01700	COG0622	Phosphoesterase
LWP59_01730	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LWP59_01735	COG3033	Beta-eliminating lyase
LWP59_01805	COG2364	Membrane
LWP59_01810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWP59_01835	COG2733	membrane
LWP59_01840	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_01845	COG3386	PFAM SMP-30 Gluconolaconase
LWP59_01870	COG1136	(ABC) transporter
LWP59_01910	COG2986	histidine ammonia-lyase
LWP59_01915	COG1174	glycine betaine transport
LWP59_01935	COG2130	NADP-dependent
LWP59_01985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LWP59_02000	COG0438	transferase activity, transferring glycosyl groups
LWP59_02010	COG0588	phosphoglycerate mutase activity
LWP59_02020	COG0667	Aldo Keto reductase
LWP59_02025	COG5002	protein histidine kinase activity
LWP59_02030	COG0745	RESPONSE REGULATOR receiver
LWP59_02045	COG1082	Xylose isomerase domain protein TIM barrel
LWP59_02050	COG0506	proline dehydrogenase activity
LWP59_02060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LWP59_02090	COG0560	Phosphoserine phosphatase
LWP59_02100	COG1595	DNA-templated transcription, initiation
LWP59_02120	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LWP59_02125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LWP59_02130	COG0181	hydroxymethylbilane synthase activity
LWP59_02135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LWP59_02135	COG1648	precorrin-2 dehydrogenase activity
LWP59_02160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LWP59_02165	COG0406	alpha-ribazole phosphatase activity
LWP59_02185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LWP59_02205	COG1522	sequence-specific DNA binding
LWP59_02215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LWP59_02240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LWP59_02245	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LWP59_02270	COG0438	transferase activity, transferring glycosyl groups
LWP59_02320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LWP59_02325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LWP59_02330	COG0649	NAD binding
LWP59_02345	COG1034	ATP synthesis coupled electron transport
LWP59_02350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LWP59_02355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LWP59_02360	COG0839	Belongs to the complex I subunit 6 family
LWP59_02365	COG0713	ATP synthesis coupled electron transport
LWP59_02380	COG1007	ATP synthesis coupled electron transport
LWP59_02390	COG0142	geranyltranstransferase activity
LWP59_02400	COG1013	pyruvate-flavodoxin oxidoreductase activity
LWP59_02405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LWP59_02405	COG0674	pyruvate-flavodoxin oxidoreductase activity
LWP59_02415	COG1522	sequence-specific DNA binding
LWP59_02420	COG1834	amidinotransferase
LWP59_02430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LWP59_02445	COG4310	Domain of unknown function (DUF2172)
LWP59_02455	COG1215	transferase activity, transferring glycosyl groups
LWP59_02470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LWP59_02480	COG0438	transferase activity, transferring glycosyl groups
LWP59_02505	COG0367	asparagine synthase
LWP59_02525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LWP59_02530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_02540	COG0501	Belongs to the peptidase M48B family
LWP59_02545	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LWP59_02550	COG0596	Alpha beta hydrolase
LWP59_02560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LWP59_02570	COG1666	GTP binding
LWP59_02625	COG1674	ftsk spoiiie
LWP59_02650	COG2186	Transcriptional regulator
LWP59_02700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LWP59_02710	COG2272	Belongs to the type-B carboxylesterase lipase family
LWP59_02730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LWP59_02740	COG0668	transmembrane transport
LWP59_02755	COG0668	transmembrane transport
LWP59_02760	COG1793	dna ligase
LWP59_02775	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LWP59_02785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWP59_02790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWP59_02795	COG1021	2,3-dihydroxybenzoate-AMP ligase
LWP59_02825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LWP59_02840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWP59_02845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWP59_02850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWP59_02860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LWP59_02890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LWP59_02895	COG1940	carbohydrate kinase activity
LWP59_02900	COG0531	amino acid
LWP59_02905	COG3250	beta-galactosidase activity
LWP59_02915	COG2030	dehydratase
LWP59_02930	COG0436	Aminotransferase
LWP59_02940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LWP59_02955	COG0081	regulation of translation
LWP59_02965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LWP59_02970	COG0222	ribosome binding
LWP59_02985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_03010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LWP59_03040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LWP59_03070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LWP59_03075	COG0049	tRNA binding
LWP59_03080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LWP59_03085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LWP59_03090	COG0051	transcription antitermination factor activity, RNA binding
LWP59_03095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LWP59_03100	COG0088	Forms part of the polypeptide exit tunnel
LWP59_03105	COG0089	rRNA binding
LWP59_03110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LWP59_03115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LWP59_03120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LWP59_03125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LWP59_03135	COG0255	Belongs to the universal ribosomal protein uL29 family
LWP59_03140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LWP59_03145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LWP59_03150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LWP59_03155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LWP59_03165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LWP59_03175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LWP59_03180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LWP59_03185	COG1841	ribosomal large subunit assembly
LWP59_03205	COG0563	adenylate kinase activity
LWP59_03215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LWP59_03220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LWP59_03225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LWP59_03235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LWP59_03240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LWP59_03245	COG0202	RNA polymerase activity
LWP59_03250	COG0203	ribosomal protein L17
LWP59_03280	COG1404	Belongs to the peptidase S8 family
LWP59_03290	COG1674	ftsk spoiiie
LWP59_03295	COG0443	Heat shock 70 kDa protein
LWP59_03320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LWP59_03325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LWP59_03330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWP59_03335	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_03365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LWP59_03375	COG1063	alcohol dehydrogenase
LWP59_03380	COG1349	DNA-binding transcription factor activity
LWP59_03385	COG1070	Carbohydrate kinase
LWP59_03390	COG3842	ATPase activity
LWP59_03395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LWP59_03400	COG2267	carboxylic ester hydrolase activity
LWP59_03415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LWP59_03415	COG0825	malonyl-CoA metabolic process
LWP59_03420	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_03435	COG0456	acetyltransferase
LWP59_03440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LWP59_03455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LWP59_03460	COG0459	protein refolding
LWP59_03505	COG0516	GMP reductase activity
LWP59_03515	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_03525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LWP59_03525	COG0519	Catalyzes the synthesis of GMP from XMP
LWP59_03540	COG2318	DinB family
LWP59_03560	COG2197	response regulator
LWP59_03565	COG0697	spore germination
LWP59_03625	COG0045	succinate-CoA ligase (ADP-forming) activity
LWP59_03650	COG0138	bifunctional purine biosynthesis protein purh
LWP59_03670	COG0587	DNA-directed DNA polymerase activity
LWP59_03675	COG2264	protein methyltransferase activity
LWP59_03690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LWP59_03700	COG2814	Major facilitator Superfamily
LWP59_03715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_03735	COG0708	Exodeoxyribonuclease III
LWP59_03770	COG0180	Tryptophanyl-tRNA synthetase
LWP59_03780	COG1136	(ABC) transporter
LWP59_03785	COG0577	efflux transmembrane transporter activity
LWP59_03785	COG1136	(ABC) transporter
LWP59_03805	COG1295	ribonuclease BN
LWP59_03810	COG1686	Belongs to the peptidase S11 family
LWP59_03820	COG1309	transcriptional regulator
LWP59_03845	COG2009	succinate dehydrogenase
LWP59_03850	COG1744	ABC transporter substrate-binding protein PnrA-like
LWP59_03855	COG3845	ABC transporter
LWP59_03865	COG1079	Belongs to the binding-protein-dependent transport system permease family
LWP59_03885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LWP59_03895	COG2271	Major facilitator Superfamily
LWP59_03915	COG2124	cytochrome p450
LWP59_03940	COG0395	ABC-type sugar transport system, permease component
LWP59_03950	COG2124	cytochrome p450
LWP59_03960	COG2027	D-alanyl-D-alanine carboxypeptidase
LWP59_03965	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_03970	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_03975	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LWP59_03995	COG0789	Transcriptional regulator
LWP59_04000	COG0667	Aldo Keto reductase
LWP59_04040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWP59_04050	COG0515	serine threonine protein kinase
LWP59_04075	COG1473	amidohydrolase
LWP59_04075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LWP59_04095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LWP59_04105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LWP59_04130	COG4770	biotin carboxylase activity
LWP59_04135	COG1301	dicarboxylic acid transport
LWP59_04140	COG0424	maF-like protein
LWP59_04180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LWP59_04190	COG0640	Transcriptional regulator
LWP59_04245	COG0596	Alpha beta hydrolase
LWP59_04250	COG3629	intracellular signal transduction
LWP59_04250	COG3903	Transcriptional regulator
LWP59_04270	COG0791	NLP P60 protein
LWP59_04270	COG1388	LysM domain
LWP59_04270	COG3103	Sh3 type 3 domain protein
LWP59_04315	COG0483	inositol monophosphate 1-phosphatase activity
LWP59_04320	COG0745	RESPONSE REGULATOR receiver
LWP59_04325	COG2205	protein histidine kinase activity
LWP59_04370	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_04375	COG1960	acyl-CoA dehydrogenase activity
LWP59_04395	COG1316	TRANSCRIPTIONal
LWP59_04400	COG1316	TRANSCRIPTIONal
LWP59_04415	COG0438	transferase activity, transferring glycosyl groups
LWP59_04430	COG0438	transferase activity, transferring glycosyl groups
LWP59_04450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LWP59_04460	COG1725	Transcriptional regulator
LWP59_04470	COG0778	Nitroreductase
LWP59_04470	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LWP59_04475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LWP59_04505	COG2171	N-acyltransferase activity
LWP59_04515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWP59_04520	COG1611	Belongs to the LOG family
LWP59_04550	COG0519	Catalyzes the synthesis of GMP from XMP
LWP59_04555	COG1024	Enoyl-CoA hydratase
LWP59_04565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LWP59_04570	COG0583	DNA-binding transcription factor activity
LWP59_04575	COG2814	Major facilitator Superfamily
LWP59_04585	COG4122	O-methyltransferase activity
LWP59_04600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWP59_04605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWP59_04620	COG2239	Acts as a magnesium transporter
LWP59_04630	COG0330	HflC and HflK could
LWP59_04635	COG1960	acyl-CoA dehydrogenase activity
LWP59_04670	COG4941	Belongs to the sigma-70 factor family
LWP59_04675	COG3795	YCII-related domain
LWP59_04700	COG0598	Magnesium transport protein CorA
LWP59_04715	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_04735	COG0613	PHP domain protein
LWP59_04740	COG2095	MarC family integral membrane protein
LWP59_04770	COG0513	Belongs to the DEAD box helicase family
LWP59_04800	COG2267	carboxylic ester hydrolase activity
LWP59_04810	COG0596	Alpha beta hydrolase
LWP59_04830	COG0243	molybdopterin cofactor binding
LWP59_04835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWP59_04840	COG2223	nitrite transmembrane transporter activity
LWP59_04845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWP59_04845	COG2146	nitrite reductase [NAD(P)H] activity
LWP59_04875	COG1953	Uracil, thiamine, allantoin
LWP59_04880	COG1802	Transcriptional regulator
LWP59_04895	COG2378	regulation of single-species biofilm formation
LWP59_04920	COG0210	DNA helicase
LWP59_04960	COG0714	Associated with various cellular activities
LWP59_05010	COG0612	Peptidase, M16
LWP59_05030	COG3265	gluconokinase activity
LWP59_05040	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LWP59_05050	COG3001	Fructosamine kinase
LWP59_05060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LWP59_05125	COG2814	Major facilitator Superfamily
LWP59_05140	COG0557	exoribonuclease II activity
LWP59_05150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWP59_05155	COG1968	undecaprenyl-diphosphatase activity
LWP59_05165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LWP59_05170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LWP59_05170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LWP59_05175	COG2318	DinB family
LWP59_05195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LWP59_05195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LWP59_05200	COG0653	protein targeting
LWP59_05225	COG0174	glutamine synthetase
LWP59_05245	COG0505	Belongs to the CarA family
LWP59_05250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LWP59_05260	COG0174	glutamine synthetase
LWP59_05300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LWP59_05320	COG3480	Lon protease (S16) C-terminal proteolytic domain
LWP59_05330	COG1615	UPF0182 protein
LWP59_05350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LWP59_05355	COG2884	Cell division ATP-binding protein ftsE
LWP59_05360	COG2177	Part of the ABC transporter FtsEX involved in
LWP59_05365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LWP59_05385	COG1846	Transcriptional regulator
LWP59_05395	COG2197	response regulator
LWP59_05400	COG4585	Histidine kinase
LWP59_05425	COG1414	Transcriptional regulator
LWP59_05430	COG2986	histidine ammonia-lyase
LWP59_05435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LWP59_05450	COG1228	amidohydrolase
LWP59_05475	COG0412	Dienelactone hydrolase
LWP59_05485	COG1643	Atp-dependent helicase
LWP59_05490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWP59_05530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LWP59_05555	COG1024	Enoyl-CoA hydratase
LWP59_05555	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWP59_05565	COG1960	acyl-CoA dehydrogenase activity
LWP59_05570	COG1960	acyl-CoA dehydrogenase activity
LWP59_05580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LWP59_05620	COG2124	cytochrome p450
LWP59_05640	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_05650	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_05660	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_05670	COG1024	Enoyl-CoA hydratase
LWP59_05675	COG2186	Transcriptional regulator
LWP59_05680	COG1024	Enoyl-CoA hydratase
LWP59_05685	COG1024	Enoyl-CoA hydratase
LWP59_05690	COG1960	acyl-CoA dehydrogenase activity
LWP59_05710	COG0459	protein refolding
LWP59_05715	COG1063	alcohol dehydrogenase
LWP59_05720	COG0489	protein tyrosine kinase activity
LWP59_05720	COG2151	metal-sulfur cluster biosynthetic enzyme
LWP59_05770	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_05775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_05780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_05830	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_05840	COG2124	cytochrome p450
LWP59_05855	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_05860	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_05865	COG1309	transcriptional regulator
LWP59_05890	COG2801	Transposase and inactivated derivatives
LWP59_05900	COG1024	Enoyl-CoA hydratase
LWP59_05905	COG1960	acyl-CoA dehydrogenase activity
LWP59_05910	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_05915	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWP59_05915	COG1024	Enoyl-CoA hydratase
LWP59_05920	COG0183	Belongs to the thiolase family
LWP59_05925	COG1309	transcriptional regulator
LWP59_05935	COG1024	Enoyl-CoA hydratase
LWP59_05940	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_05965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LWP59_06075	COG0640	Transcriptional regulator
LWP59_06095	COG0583	DNA-binding transcription factor activity
LWP59_06100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_06120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LWP59_06150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LWP59_06240	COG2018	Roadblock/LC7 domain
LWP59_06260	COG1119	ATPase activity
LWP59_06265	COG4221	oxidoreductase activity
LWP59_06285	COG0187	DNA topoisomerase II activity
LWP59_06285	COG1372	Participates in initiation and elongation during chromosome replication
LWP59_06290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LWP59_06290	COG1372	Participates in initiation and elongation during chromosome replication
LWP59_06300	COG1366	Belongs to the anti-sigma-factor antagonist family
LWP59_06305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_06310	COG0129	dihydroxy-acid dehydratase activity
LWP59_06370	COG4977	sequence-specific DNA binding
LWP59_06400	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_06405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LWP59_06410	COG3281	Trehalose synthase
LWP59_06415	COG0366	Alpha amylase catalytic
LWP59_06420	COG0366	Alpha amylase catalytic
LWP59_06460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LWP59_06470	COG2211	Major facilitator Superfamily
LWP59_06495	COG3973	AAA domain
LWP59_06500	COG3848	Pyruvate phosphate dikinase
LWP59_06500	COG0574	Belongs to the PEP-utilizing enzyme family
LWP59_06530	COG0018	arginyl-trna synthetase
LWP59_06535	COG0019	diaminopimelate decarboxylase activity
LWP59_06540	COG0460	homoserine dehydrogenase
LWP59_06545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LWP59_06550	COG0083	homoserine kinase activity
LWP59_06560	COG0254	rRNA binding
LWP59_06565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LWP59_06570	COG2890	protein-(glutamine-N5) methyltransferase activity
LWP59_06580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LWP59_06595	COG0356	it plays a direct role in the translocation of protons across the membrane
LWP59_06600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LWP59_06610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LWP59_06610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LWP59_06615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LWP59_06615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LWP59_06620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LWP59_06635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LWP59_06665	COG1280	lysine exporter protein (LysE YggA)
LWP59_06670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWP59_06670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWP59_06680	COG0765	amino acid transport
LWP59_06685	COG0765	amino acid transport
LWP59_06690	COG1126	abc transporter atp-binding protein
LWP59_06710	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_06715	COG3618	amidohydrolase
LWP59_06720	COG1414	Transcriptional regulator
LWP59_06730	COG1024	Enoyl-CoA hydratase
LWP59_06735	COG0494	nUDIX hydrolase
LWP59_06740	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LWP59_06765	COG2376	Dihydroxyacetone kinase
LWP59_06820	COG2267	carboxylic ester hydrolase activity
LWP59_06830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWP59_06835	COG3830	Belongs to the UPF0237 family
LWP59_06835	COG0560	Phosphoserine phosphatase
LWP59_06860	COG1268	BioY protein
LWP59_06875	COG1335	isochorismatase
LWP59_06880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LWP59_06895	COG3191	aminopeptidase activity
LWP59_06920	COG0705	Rhomboid family
LWP59_06925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LWP59_06930	COG1234	tRNA 3'-trailer cleavage
LWP59_06935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LWP59_06940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LWP59_06945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LWP59_06950	COG0477	Major facilitator Superfamily
LWP59_06980	COG1053	succinate dehydrogenase
LWP59_06980	COG3976	FMN-binding domain protein
LWP59_06985	COG0129	dihydroxy-acid dehydratase activity
LWP59_06990	COG0477	Major facilitator Superfamily
LWP59_07085	COG0110	maltose O-acetyltransferase activity
LWP59_07110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LWP59_07140	COG0411	ABC transporter
LWP59_07145	COG1414	Transcriptional regulator
LWP59_07160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LWP59_07175	COG1307	EDD domain protein, DegV family
LWP59_07185	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LWP59_07210	COG0482	sulfurtransferase activity
LWP59_07220	COG2201	protein-glutamate methylesterase activity
LWP59_07235	COG0456	acetyltransferase
LWP59_07240	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_07245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWP59_07265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LWP59_07280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LWP59_07320	COG0129	dihydroxy-acid dehydratase activity
LWP59_07335	COG2188	Transcriptional regulator
LWP59_07340	COG0154	amidase activity
LWP59_07360	COG0440	acetolactate synthase activity
LWP59_07365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LWP59_07395	COG1404	Belongs to the peptidase S8 family
LWP59_07400	COG0473	3-isopropylmalate dehydrogenase activity
LWP59_07405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LWP59_07415	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWP59_07430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWP59_07435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LWP59_07475	COG1216	Glycosyl transferase, family 2
LWP59_07485	COG3629	intracellular signal transduction
LWP59_07485	COG3903	Transcriptional regulator
LWP59_07490	COG1733	regulation of RNA biosynthetic process
LWP59_07505	COG3833	ABC-type maltose transport systems, permease component
LWP59_07580	COG1846	Transcriptional regulator
LWP59_07600	COG2197	response regulator
LWP59_07605	COG3903	Transcriptional regulator
LWP59_07605	COG3629	intracellular signal transduction
LWP59_07625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LWP59_07665	COG0477	Major facilitator Superfamily
LWP59_07695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_07700	COG0667	Aldo Keto reductase
LWP59_07710	COG0277	FAD linked oxidase domain protein
LWP59_07715	COG1316	TRANSCRIPTIONal
LWP59_07725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LWP59_07730	COG0066	3-isopropylmalate dehydratase activity
LWP59_07740	COG0406	alpha-ribazole phosphatase activity
LWP59_07740	COG0494	nUDIX hydrolase
LWP59_07750	COG1920	GTP binding
LWP59_07760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LWP59_07775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWP59_07780	COG1181	Belongs to the D-alanine--D-alanine ligase family
LWP59_07815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LWP59_07820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LWP59_07825	COG1461	Dihydroxyacetone kinase
LWP59_07840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LWP59_07845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LWP59_07850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_07855	COG3973	AAA domain
LWP59_07860	COG0742	ribosomal rna small subunit methyltransferase
LWP59_07880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LWP59_07885	COG0571	ribonuclease III activity
LWP59_07890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LWP59_07910	COG0367	asparagine synthase
LWP59_07920	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LWP59_07930	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LWP59_07950	COG1254	Belongs to the acylphosphatase family
LWP59_07985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_07990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LWP59_08000	COG1414	Transcriptional regulator
LWP59_08005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LWP59_08015	COG3835	regulator
LWP59_08020	COG0640	Transcriptional regulator
LWP59_08045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LWP59_08050	COG2252	PERMEase
LWP59_08055	COG1309	transcriptional regulator
LWP59_08060	COG2267	carboxylic ester hydrolase activity
LWP59_08065	COG2233	PERMEase
LWP59_08090	COG3622	Belongs to the hyi family
LWP59_08095	COG2084	Dehydrogenase
LWP59_08100	COG3960	tartronate-semialdehyde synthase activity
LWP59_08105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LWP59_08110	COG4266	Belongs to the allantoicase family
LWP59_08125	COG2873	o-acetylhomoserine
LWP59_08130	COG0667	Aldo Keto reductase
LWP59_08155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LWP59_08165	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LWP59_08175	COG1132	(ABC) transporter
LWP59_08200	COG0228	four-way junction DNA binding
LWP59_08210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LWP59_08215	COG0336	Belongs to the RNA methyltransferase TrmD family
LWP59_08220	COG0335	large ribosomal subunit rRNA binding
LWP59_08225	COG0681	Belongs to the peptidase S26 family
LWP59_08230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LWP59_08240	COG0792	nuclease activity
LWP59_08260	COG1191	sigma factor activity
LWP59_08270	COG0052	Belongs to the universal ribosomal protein uS2 family
LWP59_08275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LWP59_08280	COG0528	UMP kinase activity
LWP59_08285	COG0233	cytoplasmic translational termination
LWP59_08310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LWP59_08320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LWP59_08325	COG0750	zinc metalloprotease
LWP59_08330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LWP59_08345	COG0456	acetyltransferase
LWP59_08345	COG0454	-acetyltransferase
LWP59_08355	COG2186	Transcriptional regulator
LWP59_08390	COG0513	Belongs to the DEAD box helicase family
LWP59_08400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWP59_08405	COG3022	response to hydroperoxide
LWP59_08425	COG3250	beta-galactosidase activity
LWP59_08435	COG1609	Transcriptional regulator
LWP59_08465	COG2902	Dehydrogenase
LWP59_08470	COG0824	Thioesterase
LWP59_08480	COG2272	Belongs to the type-B carboxylesterase lipase family
LWP59_08495	COG0668	transmembrane transport
LWP59_08510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LWP59_08520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LWP59_08525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWP59_08530	COG0698	ribose 5-phosphate isomerase
LWP59_08620	COG0582	viral genome integration into host DNA
LWP59_08650	COG3384	dioxygenase
LWP59_08670	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_08675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWP59_08680	COG1414	Transcriptional regulator
LWP59_08685	COG2197	response regulator
LWP59_08690	COG3959	Transketolase, thiamine diphosphate binding domain
LWP59_08725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_08730	COG1127	ABC transporter
LWP59_08770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWP59_08800	COG1294	oxidase, subunit
LWP59_08805	COG1271	oxidase subunit
LWP59_08810	COG2208	phosphoserine phosphatase activity
LWP59_08810	COG2770	Histidine kinase
LWP59_08820	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_08835	COG4941	Belongs to the sigma-70 factor family
LWP59_08850	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LWP59_08925	COG0583	DNA-binding transcription factor activity
LWP59_08940	COG1309	transcriptional regulator
LWP59_08950	COG0789	Transcriptional regulator
LWP59_08970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LWP59_08975	COG2205	protein histidine kinase activity
LWP59_09000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LWP59_09015	COG0544	peptidyl-prolyl cis-trans isomerase activity
LWP59_09020	COG0740	serine-type endopeptidase activity
LWP59_09025	COG0740	serine-type endopeptidase activity
LWP59_09045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LWP59_09080	COG0477	Major facilitator Superfamily
LWP59_09085	COG1846	Transcriptional regulator
LWP59_09110	COG1960	acyl-CoA dehydrogenase activity
LWP59_09115	COG0154	amidase activity
LWP59_09125	COG0285	dihydrofolate synthase activity
LWP59_09135	COG0105	UTP biosynthetic process
LWP59_09140	COG1414	Transcriptional regulator
LWP59_09145	COG1131	(ABC) transporter
LWP59_09165	COG1530	ribonuclease E activity
LWP59_09165	COG1530	ribonuclease E activity
LWP59_09170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LWP59_09175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LWP59_09180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LWP59_09195	COG0477	Major facilitator Superfamily
LWP59_09205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LWP59_09215	COG0799	negative regulation of ribosome biogenesis
LWP59_09230	COG1307	EDD domain protein, DegV family
LWP59_09245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LWP59_09255	COG0268	Binds directly to 16S ribosomal RNA
LWP59_09290	COG0481	GTPase activity
LWP59_09300	COG2070	2-Nitropropane dioxygenase
LWP59_09310	COG0604	alcohol dehydrogenase
LWP59_09320	COG4290	ribonuclease
LWP59_09325	COG2732	(Barnase) inhibitor
LWP59_09330	COG1024	Enoyl-CoA hydratase
LWP59_09350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWP59_09355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LWP59_09375	COG0175	sulfate reduction
LWP59_09430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LWP59_09435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LWP59_09445	COG0577	efflux transmembrane transporter activity
LWP59_09445	COG1136	(ABC) transporter
LWP59_09450	COG0577	efflux transmembrane transporter activity
LWP59_09470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LWP59_09480	COG1953	Uracil, thiamine, allantoin
LWP59_09495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWP59_09515	COG0484	heat shock protein binding
LWP59_09525	COG0537	adenosine 5'-monophosphoramidase activity
LWP59_09535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LWP59_09550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LWP59_09555	COG1381	Involved in DNA repair and RecF pathway recombination
LWP59_09560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LWP59_09570	COG0701	Predicted permease
LWP59_09595	COG0423	glycine-tRNA ligase activity
LWP59_09600	COG1131	(ABC) transporter
LWP59_09610	COG4585	Histidine kinase
LWP59_09615	COG2197	response regulator
LWP59_09625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LWP59_09640	COG2267	carboxylic ester hydrolase activity
LWP59_09650	COG1595	DNA-templated transcription, initiation
LWP59_09665	COG4106	trans-aconitate 2-methyltransferase activity
LWP59_09680	COG1609	Transcriptional regulator
LWP59_09720	COG1674	ftsk spoiiie
LWP59_09770	COG1063	alcohol dehydrogenase
LWP59_09780	COG1024	Enoyl-CoA hydratase
LWP59_09795	COG0604	alcohol dehydrogenase
LWP59_09800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LWP59_09815	COG2124	cytochrome p450
LWP59_09835	COG1309	transcriptional regulator
LWP59_09845	COG1228	amidohydrolase
LWP59_09870	COG2233	PERMEase
LWP59_09895	COG0596	Alpha beta hydrolase
LWP59_09910	COG0583	DNA-binding transcription factor activity
LWP59_09915	COG1802	Transcriptional regulator
LWP59_09925	COG4977	sequence-specific DNA binding
LWP59_09930	COG1802	Transcriptional regulator
LWP59_09945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWP59_09965	COG1309	transcriptional regulator
LWP59_09975	COG2814	Major facilitator Superfamily
LWP59_09980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LWP59_09995	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_10000	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_10005	COG1960	acyl-CoA dehydrogenase activity
LWP59_10010	COG1960	acyl-CoA dehydrogenase activity
LWP59_10015	COG2030	dehydratase
LWP59_10070	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_10075	COG1316	TRANSCRIPTIONal
LWP59_10125	COG1233	COG1233 Phytoene dehydrogenase and related
LWP59_10165	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_10185	COG2318	DinB family
LWP59_10190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LWP59_10195	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LWP59_10200	COG2080	2 iron, 2 sulfur cluster binding
LWP59_10205	COG1024	Enoyl-CoA hydratase
LWP59_10225	COG4941	Belongs to the sigma-70 factor family
LWP59_10235	COG0477	Major facilitator Superfamily
LWP59_10245	COG2271	Major facilitator Superfamily
LWP59_10250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LWP59_10285	COG2188	Transcriptional regulator
LWP59_10295	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LWP59_10300	COG2301	Belongs to the HpcH HpaI aldolase family
LWP59_10305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_10310	COG0439	Biotin carboxylase
LWP59_10325	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_10330	COG0506	proline dehydrogenase activity
LWP59_10345	COG0671	phosphoesterase, PA-phosphatase related
LWP59_10360	COG0439	Biotin carboxylase
LWP59_10370	COG1984	allophanate hydrolase subunit 2
LWP59_10380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LWP59_10385	COG1984	allophanate hydrolase subunit 2
LWP59_10390	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LWP59_10405	COG0477	Major facilitator Superfamily
LWP59_10410	COG0583	DNA-binding transcription factor activity
LWP59_10415	COG0667	Aldo Keto reductase
LWP59_10435	COG2186	Transcriptional regulator
LWP59_10440	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWP59_10445	COG0596	Alpha beta hydrolase
LWP59_10450	COG1228	amidohydrolase
LWP59_10505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LWP59_10515	COG0477	Major facilitator Superfamily
LWP59_10520	COG0405	Gamma-glutamyltransferase
LWP59_10525	COG3345	alpha-galactosidase
LWP59_10530	COG1247	-acetyltransferase
LWP59_10535	COG0492	ferredoxin-NADP+ reductase activity
LWP59_10555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LWP59_10590	COG0367	asparagine synthase
LWP59_10655	COG3903	Transcriptional regulator
LWP59_10655	COG3629	intracellular signal transduction
LWP59_10660	COG0477	Major facilitator Superfamily
LWP59_10685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LWP59_10720	COG1834	amidinotransferase
LWP59_10725	COG2124	cytochrome p450
LWP59_10750	COG2124	cytochrome p450
LWP59_10765	COG2801	Transposase and inactivated derivatives
LWP59_10810	COG0252	asparaginase activity
LWP59_10835	COG0175	sulfate reduction
LWP59_10875	COG0779	Required for maturation of 30S ribosomal subunits
LWP59_10890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LWP59_10900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LWP59_10910	COG0477	Major facilitator Superfamily
LWP59_10920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LWP59_10950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LWP59_10965	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LWP59_10970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LWP59_10975	COG1185	polyribonucleotide nucleotidyltransferase activity
LWP59_10980	COG0612	Peptidase, M16
LWP59_10985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LWP59_10995	COG0596	Alpha beta hydrolase
LWP59_11025	COG3214	Protein conserved in bacteria
LWP59_11055	COG0515	serine threonine protein kinase
LWP59_11060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWP59_11065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LWP59_11075	COG5006	permease, DMT superfamily
LWP59_11080	COG0655	NAD(P)H dehydrogenase (quinone) activity
LWP59_11085	COG0477	Major facilitator Superfamily
LWP59_11100	COG1674	ftsk spoiiie
LWP59_11105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LWP59_11120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LWP59_11130	COG1546	Belongs to the CinA family
LWP59_11130	COG1058	Belongs to the CinA family
LWP59_11135	COG1396	sequence-specific DNA binding
LWP59_11140	COG1842	Phage shock protein A
LWP59_11150	COG0154	amidase activity
LWP59_11155	COG0167	dihydroorotate dehydrogenase activity
LWP59_11165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LWP59_11170	COG0455	bacterial-type flagellum organization
LWP59_11180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LWP59_11190	COG1305	Transglutaminase-like
LWP59_11200	COG0714	Associated with various cellular activities
LWP59_11225	COG2001	Belongs to the MraZ family
LWP59_11230	COG0275	rRNA processing
LWP59_11240	COG0768	penicillin binding
LWP59_11255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LWP59_11260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LWP59_11270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LWP59_11275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LWP59_11285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LWP59_11300	COG1799	cell septum assembly
LWP59_11320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LWP59_11325	COG0768	penicillin binding
LWP59_11330	COG0477	Major facilitator Superfamily
LWP59_11335	COG0640	Transcriptional regulator
LWP59_11350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LWP59_11380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_11390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LWP59_11415	COG0640	Transcriptional regulator
LWP59_11440	COG0542	response to heat
LWP59_11460	COG0297	glycogen (starch) synthase activity
LWP59_11465	COG3546	catalase activity
LWP59_11475	COG0859	PFAM glycosyl transferase family 9
LWP59_11480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LWP59_11485	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LWP59_11485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LWP59_11490	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_11525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWP59_11555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LWP59_11575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWP59_11575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWP59_11580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWP59_11580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWP59_11605	COG1129	ABC transporter
LWP59_11610	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_11620	COG2186	Transcriptional regulator
LWP59_11625	COG3386	PFAM SMP-30 Gluconolaconase
LWP59_11635	COG1316	TRANSCRIPTIONal
LWP59_11650	COG0237	dephospho-CoA kinase activity
LWP59_11650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LWP59_11655	COG2226	methyltransferase
LWP59_11705	COG1131	(ABC) transporter
LWP59_11715	COG1506	peptidase
LWP59_11715	COG4946	Tricorn protease homolog
LWP59_11715	COG0823	Involved in the tonB-independent uptake of proteins
LWP59_11735	COG1129	ABC transporter
LWP59_11740	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_11750	COG1609	Transcriptional regulator
LWP59_11755	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
LWP59_11760	COG1070	Carbohydrate kinase
LWP59_11765	COG1285	pathogenesis
LWP59_11785	COG2267	carboxylic ester hydrolase activity
LWP59_11805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWP59_11830	COG1301	dicarboxylic acid transport
LWP59_11835	COG3290	protein histidine kinase activity
LWP59_11840	COG4565	transcriptional regulatory protein
LWP59_11885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LWP59_11890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LWP59_11895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWP59_11900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LWP59_11905	COG0072	phenylalanine-tRNA ligase activity
LWP59_11905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWP59_11925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LWP59_11930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LWP59_11935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LWP59_11940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWP59_11950	COG1438	arginine binding
LWP59_11955	COG0137	argininosuccinate synthase activity
LWP59_11960	COG0165	Argininosuccinate lyase
LWP59_11975	COG2094	Belongs to the DNA glycosylase MPG family
LWP59_11980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LWP59_12010	COG0647	UMP catabolic process
LWP59_12025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LWP59_12065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LWP59_12070	COG0504	CTP synthase activity
LWP59_12075	COG0494	nUDIX hydrolase
LWP59_12095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LWP59_12100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LWP59_12110	COG0514	ATP-dependent DNA helicase (RecQ)
LWP59_12125	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_12130	COG0246	Mannitol dehydrogenase
LWP59_12135	COG1063	alcohol dehydrogenase
LWP59_12140	COG0475	glutathione-regulated potassium exporter activity
LWP59_12160	COG1160	GTP binding
LWP59_12180	COG3383	formate dehydrogenase (NAD+) activity
LWP59_12195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LWP59_12200	COG1414	Transcriptional regulator
LWP59_12215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LWP59_12230	COG0028	Belongs to the TPP enzyme family
LWP59_12240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_12250	COG1024	Enoyl-CoA hydratase
LWP59_12255	COG1960	acyl-CoA dehydrogenase activity
LWP59_12260	COG1063	alcohol dehydrogenase
LWP59_12265	COG0022	dehydrogenase e1 component
LWP59_12270	COG1309	transcriptional regulator
LWP59_12295	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_12300	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_12305	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_12310	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_12335	COG1609	Transcriptional regulator
LWP59_12350	COG0395	ABC-type sugar transport system, permease component
LWP59_12390	COG4977	sequence-specific DNA binding
LWP59_12395	COG1396	sequence-specific DNA binding
LWP59_12405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWP59_12410	COG1609	Transcriptional regulator
LWP59_12415	COG1879	ABC-type sugar transport system periplasmic component
LWP59_12420	COG1129	ABC transporter
LWP59_12425	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_12430	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_12455	COG2368	4-hydroxyphenylacetate
LWP59_12480	COG2814	Major facilitator Superfamily
LWP59_12485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWP59_12495	COG0066	3-isopropylmalate dehydratase activity
LWP59_12500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LWP59_12505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LWP59_12510	COG0066	3-isopropylmalate dehydratase activity
LWP59_12530	COG2814	Major facilitator Superfamily
LWP59_12555	COG4208	sulfate ABC transporter
LWP59_12570	COG0673	inositol 2-dehydrogenase activity
LWP59_12595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LWP59_12610	COG2814	Major facilitator Superfamily
LWP59_12645	COG0640	Transcriptional regulator
LWP59_12710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LWP59_12715	COG1595	DNA-templated transcription, initiation
LWP59_12730	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_12745	COG0604	alcohol dehydrogenase
LWP59_12745	COG4221	oxidoreductase activity
LWP59_12745	COG3321	synthase
LWP59_12745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LWP59_12750	COG1024	Enoyl-CoA hydratase
LWP59_12755	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_12760	COG2030	dehydratase
LWP59_12765	COG2030	dehydratase
LWP59_12770	COG1960	acyl-CoA dehydrogenase activity
LWP59_12775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWP59_12780	COG2186	Transcriptional regulator
LWP59_12795	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_12800	COG0183	Belongs to the thiolase family
LWP59_12805	COG0427	acetyl-CoA hydrolase
LWP59_12810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LWP59_12820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LWP59_12825	COG1024	Enoyl-CoA hydratase
LWP59_12855	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_12860	COG1960	acyl-CoA dehydrogenase activity
LWP59_12865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LWP59_12900	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_12945	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_12970	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_12975	COG1129	ABC transporter
LWP59_13005	COG1609	Transcriptional regulator
LWP59_13015	COG0395	ABC-type sugar transport system, permease component
LWP59_13020	COG1175	transmembrane transport
LWP59_13030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LWP59_13035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LWP59_13045	COG0395	ABC-type sugar transport system, permease component
LWP59_13050	COG1175	transmembrane transport
LWP59_13060	COG1501	Belongs to the glycosyl hydrolase 31 family
LWP59_13075	COG1609	Transcriptional regulator
LWP59_13085	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_13145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_13170	COG3850	Histidine kinase
LWP59_13175	COG2197	response regulator
LWP59_13185	COG0477	Major facilitator Superfamily
LWP59_13190	COG1414	Transcriptional regulator
LWP59_13200	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LWP59_13205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWP59_13210	COG1609	Transcriptional regulator
LWP59_13220	COG2030	dehydratase
LWP59_13225	COG1960	acyl-CoA dehydrogenase activity
LWP59_13230	COG1024	Enoyl-CoA hydratase
LWP59_13235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_13240	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_13245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LWP59_13250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LWP59_13255	COG2271	Major facilitator Superfamily
LWP59_13265	COG1802	Transcriptional regulator
LWP59_13270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LWP59_13295	COG0671	phosphoesterase, PA-phosphatase related
LWP59_13305	COG0726	polysaccharide deacetylase
LWP59_13320	COG2205	protein histidine kinase activity
LWP59_13335	COG0745	RESPONSE REGULATOR receiver
LWP59_13350	COG0438	transferase activity, transferring glycosyl groups
LWP59_13350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LWP59_13365	COG2205	protein histidine kinase activity
LWP59_13370	COG1492	cobalamin metabolic process
LWP59_13375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LWP59_13380	COG2197	response regulator
LWP59_13385	COG4585	Histidine kinase
LWP59_13425	COG1082	Xylose isomerase domain protein TIM barrel
LWP59_13445	COG1129	ABC transporter
LWP59_13455	COG1082	Xylose isomerase domain protein TIM barrel
LWP59_13460	COG0673	inositol 2-dehydrogenase activity
LWP59_13465	COG1082	Xylose isomerase domain protein TIM barrel
LWP59_13495	COG1940	carbohydrate kinase activity
LWP59_13505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LWP59_13515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWP59_13520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_13525	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_13530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LWP59_13605	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LWP59_13625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LWP59_13635	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_13640	COG0596	Alpha beta hydrolase
LWP59_13655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_13660	COG1802	Transcriptional regulator
LWP59_13665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LWP59_13670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_13670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_13695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LWP59_13700	COG1984	allophanate hydrolase subunit 2
LWP59_13705	COG4336	lyase activity
LWP59_13730	COG1175	transmembrane transport
LWP59_13740	COG3842	ATPase activity
LWP59_13745	COG3457	Alanine racemase
LWP59_13750	COG1940	carbohydrate kinase activity
LWP59_13755	COG2971	BadF BadG BcrA BcrD
LWP59_13760	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LWP59_13775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_13785	COG0154	amidase activity
LWP59_13815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWP59_13835	COG0477	Major facilitator Superfamily
LWP59_13855	COG1021	2,3-dihydroxybenzoate-AMP ligase
LWP59_13860	COG0183	Belongs to the thiolase family
LWP59_13865	COG1960	acyl-CoA dehydrogenase activity
LWP59_13870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWP59_13885	COG2963	transposase activity
LWP59_13905	COG1376	ErfK ybiS ycfS ynhG family protein
LWP59_13925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWP59_13930	COG1116	anion transmembrane transporter activity
LWP59_13935	COG3290	protein histidine kinase activity
LWP59_14065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LWP59_14090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LWP59_14100	COG1216	Glycosyl transferase, family 2
LWP59_14105	COG1215	transferase activity, transferring glycosyl groups
LWP59_14140	COG1215	transferase activity, transferring glycosyl groups
LWP59_14150	COG0778	Nitroreductase
LWP59_14155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LWP59_14180	COG1560	Kdo2-lipid A biosynthetic process
LWP59_14185	COG0438	transferase activity, transferring glycosyl groups
LWP59_14205	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LWP59_14215	COG0217	transcriptional regulatory protein
LWP59_14225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LWP59_14230	COG0632	four-way junction helicase activity
LWP59_14235	COG2255	four-way junction helicase activity
LWP59_14245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWP59_14250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWP59_14255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LWP59_14265	COG1024	Enoyl-CoA hydratase
LWP59_14300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWP59_14315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LWP59_14330	COG2040	homocysteine
LWP59_14370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LWP59_14415	COG1414	Transcriptional regulator
LWP59_14425	COG2124	cytochrome p450
LWP59_14430	COG0247	lactate metabolic process
LWP59_14435	COG1139	Iron-sulfur cluster binding protein
LWP59_14440	COG1556	Lactate utilization protein
LWP59_14450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWP59_14460	COG0515	serine threonine protein kinase
LWP59_14470	COG2304	oxidoreductase activity
LWP59_14480	COG2197	response regulator
LWP59_14500	COG0583	DNA-binding transcription factor activity
LWP59_14510	COG0800	Aldolase
LWP59_14520	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_14525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWP59_14545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LWP59_14590	COG1960	acyl-CoA dehydrogenase activity
LWP59_14610	COG0477	Major facilitator Superfamily
LWP59_14635	COG3104	oligopeptide transport
LWP59_14655	COG3795	YCII-related domain
LWP59_14660	COG4941	Belongs to the sigma-70 factor family
LWP59_14705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWP59_14785	COG1511	domain protein
LWP59_14800	COG2226	methyltransferase
LWP59_14805	COG0539	negative regulation of cytoplasmic translation
LWP59_14815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LWP59_14850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_14855	COG2211	Major facilitator Superfamily
LWP59_14860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWP59_14865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LWP59_14875	COG1648	precorrin-2 dehydrogenase activity
LWP59_14875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LWP59_14890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWP59_14920	COG1716	ATPase activity
LWP59_14990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LWP59_14995	COG0121	glutamine amidotransferase
LWP59_15000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LWP59_15015	COG2837	iron assimilation
LWP59_15020	COG3511	phospholipase C
LWP59_15025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LWP59_15040	COG3883	PFAM NLP P60 protein
LWP59_15040	COG0791	NLP P60 protein
LWP59_15050	COG0746	molybdenum cofactor guanylyltransferase activity
LWP59_15055	COG0714	Associated with various cellular activities
LWP59_15065	COG2304	oxidoreductase activity
LWP59_15070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LWP59_15080	COG1335	isochorismatase
LWP59_15090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LWP59_15095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LWP59_15105	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LWP59_15130	COG0215	cysteine-tRNA ligase activity
LWP59_15135	COG0488	(ABC) transporter
LWP59_15145	COG2814	Major facilitator Superfamily
LWP59_15150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LWP59_15165	COG1410	methionine synthase
LWP59_15165	COG0646	methionine synthase
LWP59_15175	COG0140	phosphoribosyl-ATP diphosphatase activity
LWP59_15185	COG4221	oxidoreductase activity
LWP59_15190	COG1192	Involved in chromosome partitioning
LWP59_15205	COG1994	Peptidase M50
LWP59_15205	COG0517	IMP dehydrogenase activity
LWP59_15225	COG1222	aaa ATPase
LWP59_15260	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LWP59_15265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LWP59_15270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LWP59_15280	COG2409	Drug exporters of the RND superfamily
LWP59_15295	COG2378	regulation of single-species biofilm formation
LWP59_15300	COG2378	regulation of single-species biofilm formation
LWP59_15310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWP59_15350	COG4152	abc transporter atp-binding protein
LWP59_15380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWP59_15405	COG0477	Major facilitator Superfamily
LWP59_15415	COG3938	Belongs to the proline racemase family
LWP59_15420	COG2423	ornithine cyclodeaminase activity
LWP59_15450	COG2018	Roadblock/LC7 domain
LWP59_15455	COG0642	Histidine kinase
LWP59_15475	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_15480	COG1129	ABC transporter
LWP59_15500	COG1228	amidohydrolase
LWP59_15515	COG2197	response regulator
LWP59_15540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LWP59_15545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWP59_15600	COG1366	Belongs to the anti-sigma-factor antagonist family
LWP59_15605	COG1366	Belongs to the anti-sigma-factor antagonist family
LWP59_15610	COG2172	sigma factor antagonist activity
LWP59_15635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LWP59_15670	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_15685	COG0306	phosphate transporter
LWP59_15690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWP59_15705	COG0667	Aldo Keto reductase
LWP59_15710	COG1968	undecaprenyl-diphosphatase activity
LWP59_15720	COG0339	signal peptide processing
LWP59_15725	COG0039	L-malate dehydrogenase activity
LWP59_15740	COG3537	Alpha-1,2-mannosidase
LWP59_15745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWP59_15750	COG2362	D-Aminopeptidase
LWP59_15770	COG0297	glycogen (starch) synthase activity
LWP59_15795	COG1024	Enoyl-CoA hydratase
LWP59_15810	COG0601	transmembrane transport
LWP59_15820	COG4608	Belongs to the ABC transporter superfamily
LWP59_15835	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_15850	COG1960	acyl-CoA dehydrogenase activity
LWP59_15855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_15880	COG2175	clavaminate synthase activity
LWP59_15885	COG0546	phosphoglycolate phosphatase activity
LWP59_15925	COG2226	methyltransferase
LWP59_15975	COG2814	Major facilitator Superfamily
LWP59_15980	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_15995	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_16010	COG2814	Major facilitator Superfamily
LWP59_16010	COG0477	Major facilitator Superfamily
LWP59_16020	COG2159	amidohydrolase
LWP59_16045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LWP59_16085	COG0431	NADPH-dependent FMN reductase
LWP59_16100	COG2837	iron assimilation
LWP59_16115	COG2301	Belongs to the HpcH HpaI aldolase family
LWP59_16125	COG0367	asparagine synthase
LWP59_16135	COG0405	Gamma-glutamyltransferase
LWP59_16145	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_16155	COG2186	Transcriptional regulator
LWP59_16165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_16205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LWP59_16280	COG5416	Lipopolysaccharide assembly protein A domain
LWP59_16295	COG0330	HflC and HflK could
LWP59_16320	COG1960	acyl-CoA dehydrogenase activity
LWP59_16340	COG1960	acyl-CoA dehydrogenase activity
LWP59_16345	COG1309	transcriptional regulator
LWP59_16380	COG1960	acyl-CoA dehydrogenase activity
LWP59_16385	COG1960	acyl-CoA dehydrogenase activity
LWP59_16395	COG1609	Transcriptional regulator
LWP59_16410	COG1024	Enoyl-CoA hydratase
LWP59_16420	COG0667	Aldo Keto reductase
LWP59_16440	COG1024	Enoyl-CoA hydratase
LWP59_16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_16460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_16465	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_16505	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_16510	COG1335	isochorismatase
LWP59_16520	COG1960	acyl-CoA dehydrogenase activity
LWP59_16525	COG1960	acyl-CoA dehydrogenase activity
LWP59_16585	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_16590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_16600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_16630	COG2124	cytochrome p450
LWP59_16635	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_16650	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_16660	COG1960	acyl-CoA dehydrogenase activity
LWP59_16675	COG1414	Transcriptional regulator
LWP59_16690	COG3158	transport of potassium into the cell
LWP59_16730	COG1082	Xylose isomerase domain protein TIM barrel
LWP59_16735	COG2706	6-phosphogluconolactonase activity
LWP59_16795	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LWP59_16800	COG1113	amino acid transport
LWP59_16810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LWP59_16815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LWP59_16820	COG2080	2 iron, 2 sulfur cluster binding
LWP59_16880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWP59_16885	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWP59_16905	COG0778	Nitroreductase
LWP59_16920	COG0038	chloride channel
LWP59_16950	COG2272	Belongs to the type-B carboxylesterase lipase family
LWP59_16970	COG2186	Transcriptional regulator
LWP59_16980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LWP59_16985	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWP59_16995	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LWP59_17000	COG0006	proline dipeptidase activity
LWP59_17010	COG0402	S-adenosylhomocysteine deaminase activity
LWP59_17015	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LWP59_17055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWP59_17060	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_17065	COG1960	acyl-CoA dehydrogenase activity
LWP59_17070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_17120	COG1960	acyl-CoA dehydrogenase activity
LWP59_17125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_17135	COG2271	Major facilitator Superfamily
LWP59_17140	COG1960	acyl-CoA dehydrogenase activity
LWP59_17155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_17200	COG1335	isochorismatase
LWP59_17215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_17220	COG1024	Enoyl-CoA hydratase
LWP59_17225	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_17230	COG1960	acyl-CoA dehydrogenase activity
LWP59_17235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_17240	COG1024	Enoyl-CoA hydratase
LWP59_17245	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_17255	COG4638	Rieske (2fe-2S)
LWP59_17275	COG2267	carboxylic ester hydrolase activity
LWP59_17280	COG3971	2-oxopent-4-enoate hydratase activity
LWP59_17290	COG1960	acyl-CoA dehydrogenase activity
LWP59_17295	COG1960	acyl-CoA dehydrogenase activity
LWP59_17305	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_17315	COG1309	transcriptional regulator
LWP59_17345	COG1024	Enoyl-CoA hydratase
LWP59_17355	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_17375	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_17390	COG2116	formate transmembrane transporter activity
LWP59_17395	COG1063	alcohol dehydrogenase
LWP59_17415	COG2814	Major facilitator Superfamily
LWP59_17420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWP59_17425	COG0583	DNA-binding transcription factor activity
LWP59_17440	COG2368	4-hydroxyphenylacetate
LWP59_17455	COG0513	Belongs to the DEAD box helicase family
LWP59_17460	COG2205	protein histidine kinase activity
LWP59_17465	COG0745	RESPONSE REGULATOR receiver
LWP59_17480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWP59_17480	COG1017	nitric oxide dioxygenase activity
LWP59_17490	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LWP59_17495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_17505	COG0477	Major facilitator Superfamily
LWP59_17525	COG0427	acetyl-CoA hydrolase
LWP59_17535	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_17550	COG0740	serine-type endopeptidase activity
LWP59_17555	COG0740	serine-type endopeptidase activity
LWP59_17560	COG2072	flavoprotein involved in K transport
LWP59_17580	COG2144	transferase activity, transferring acyl groups
LWP59_17585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LWP59_17615	COG2309	aminopeptidase activity
LWP59_17620	COG0596	Alpha beta hydrolase
LWP59_17650	COG1335	isochorismatase
LWP59_17660	COG1802	Transcriptional regulator
LWP59_17675	COG3250	beta-galactosidase activity
LWP59_17680	COG0395	ABC-type sugar transport system, permease component
LWP59_17685	COG1175	transmembrane transport
LWP59_17695	COG1609	Transcriptional regulator
LWP59_17725	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_17750	COG0837	glucose binding
LWP59_17750	COG1737	Transcriptional regulator
LWP59_17765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWP59_17800	COG0302	gtp cyclohydrolase
LWP59_17845	COG0438	transferase activity, transferring glycosyl groups
LWP59_17890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LWP59_17900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LWP59_17905	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_17910	COG4638	Rieske (2fe-2S)
LWP59_17960	COG2814	Major facilitator Superfamily
LWP59_18010	COG0701	Predicted permease
LWP59_18025	COG2909	trisaccharide binding
LWP59_18030	COG0628	permease
LWP59_18100	COG3387	PFAM Glycoside hydrolase 15-related
LWP59_18185	COG2814	Major facilitator Superfamily
LWP59_18190	COG0167	dihydroorotate dehydrogenase activity
LWP59_18195	COG2079	MmgE PrpD family protein
LWP59_18215	COG0252	asparaginase activity
LWP59_18255	COG2205	protein histidine kinase activity
LWP59_18260	COG0745	RESPONSE REGULATOR receiver
LWP59_18290	COG3344	reverse transcriptase
LWP59_18315	COG0693	protein deglycase activity
LWP59_18320	COG1063	alcohol dehydrogenase
LWP59_18325	COG2197	response regulator
LWP59_18335	COG0596	Alpha beta hydrolase
LWP59_18490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LWP59_18545	COG1674	ftsk spoiiie
LWP59_18560	COG0183	Belongs to the thiolase family
LWP59_18565	COG1960	acyl-CoA dehydrogenase activity
LWP59_18570	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWP59_18575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LWP59_18580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LWP59_18585	COG0583	DNA-binding transcription factor activity
LWP59_18590	COG0477	Major facilitator Superfamily
LWP59_18595	COG0477	Major facilitator Superfamily
LWP59_18605	COG2205	protein histidine kinase activity
LWP59_18605	COG4999	Histidine kinase
LWP59_18605	COG3850	Histidine kinase
LWP59_18605	COG3437	response regulator, receiver
LWP59_18615	COG1960	acyl-CoA dehydrogenase activity
LWP59_18620	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_18630	COG1960	acyl-CoA dehydrogenase activity
LWP59_18635	COG1960	acyl-CoA dehydrogenase activity
LWP59_18640	COG0183	Belongs to the thiolase family
LWP59_18645	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_18685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWP59_18690	COG1063	alcohol dehydrogenase
LWP59_18705	COG1024	Enoyl-CoA hydratase
LWP59_18715	COG1802	Transcriptional regulator
LWP59_18720	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_18735	COG0559	Belongs to the binding-protein-dependent transport system permease family
LWP59_18775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LWP59_18780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LWP59_18805	COG1472	Belongs to the glycosyl hydrolase 3 family
LWP59_18815	COG1522	sequence-specific DNA binding
LWP59_18835	COG1136	(ABC) transporter
LWP59_18840	COG1136	(ABC) transporter
LWP59_18855	COG0697	spore germination
LWP59_18860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LWP59_18870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LWP59_18870	COG1796	DNA polymerase
LWP59_18875	COG1357	PFAM Pentapeptide repeats (8 copies)
LWP59_18880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWP59_18885	COG1509	lysine 2,3-aminomutase activity
LWP59_18900	COG0463	Glycosyl transferase, family 2
LWP59_18910	COG1435	thymidine kinase activity
LWP59_18920	COG0584	glycerophosphoryl diester phosphodiesterase
LWP59_18955	COG2890	protein-(glutamine-N5) methyltransferase activity
LWP59_18960	COG1802	Transcriptional regulator
LWP59_18965	COG1119	ATPase activity
LWP59_18980	COG0583	DNA-binding transcription factor activity
LWP59_18990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LWP59_19015	COG2755	lipolytic protein G-D-S-L family
LWP59_19020	COG0477	Major facilitator Superfamily
LWP59_19045	COG1733	regulation of RNA biosynthetic process
LWP59_19115	COG1619	proteins homologs of microcin C7 resistance protein MccF
LWP59_19135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWP59_19140	COG0601	transmembrane transport
LWP59_19160	COG1064	alcohol dehydrogenase
LWP59_19205	COG1213	nucleotidyl transferase
LWP59_19210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LWP59_19215	COG0529	Catalyzes the synthesis of activated sulfate
LWP59_19220	COG3848	Pyruvate phosphate dikinase
LWP59_19220	COG0574	Belongs to the PEP-utilizing enzyme family
LWP59_19225	COG0477	Major facilitator Superfamily
LWP59_19230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LWP59_19235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LWP59_19255	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LWP59_19260	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_19285	COG2226	methyltransferase
LWP59_19290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_19295	COG0784	Response regulator, receiver
LWP59_19300	COG4251	negative regulation of phosphorylation
LWP59_19325	COG0657	acetylesterase activity
LWP59_19330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_19340	COG1070	Carbohydrate kinase
LWP59_19350	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_19350	COG3347	Dehydrogenase
LWP59_19370	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_19375	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_19380	COG1129	ABC transporter
LWP59_19385	COG1609	Transcriptional regulator
LWP59_19405	COG0444	Belongs to the ABC transporter superfamily
LWP59_19410	COG4608	Belongs to the ABC transporter superfamily
LWP59_19415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LWP59_19420	COG1993	acr, cog1993
LWP59_19425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LWP59_19440	COG4555	ABC transporter
LWP59_19445	COG0142	geranyltranstransferase activity
LWP59_19465	COG1472	Belongs to the glycosyl hydrolase 3 family
LWP59_19480	COG3540	Alkaline phosphatase
LWP59_19495	COG0483	inositol monophosphate 1-phosphatase activity
LWP59_19500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_19500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_19520	COG0297	glycogen (starch) synthase activity
LWP59_19615	COG1984	allophanate hydrolase subunit 2
LWP59_19625	COG1982	Orn Lys Arg decarboxylase major
LWP59_19660	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LWP59_19670	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_19675	COG0477	Major facilitator Superfamily
LWP59_19695	COG4608	Belongs to the ABC transporter superfamily
LWP59_19775	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_19795	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_19800	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_19805	COG2186	Transcriptional regulator
LWP59_19815	COG2197	response regulator
LWP59_19820	COG4585	Histidine kinase
LWP59_19870	COG1802	Transcriptional regulator
LWP59_19890	COG0667	Aldo Keto reductase
LWP59_19905	COG3953	SLT domain
LWP59_19905	COG5280	Phage tail tape measure protein TP901
LWP59_19915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_19925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_19930	COG0640	Transcriptional regulator
LWP59_19935	COG2814	Major facilitator Superfamily
LWP59_19965	COG0667	Aldo Keto reductase
LWP59_19985	COG0437	4 iron, 4 sulfur cluster binding
LWP59_19995	COG3276	selenocysteine insertion sequence binding
LWP59_20010	COG0709	Synthesizes selenophosphate from selenide and ATP
LWP59_20040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LWP59_20055	COG0375	protein maturation
LWP59_20065	COG0409	Hydrogenase expression formation protein
LWP59_20110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LWP59_20120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LWP59_20190	COG4941	Belongs to the sigma-70 factor family
LWP59_20205	COG2186	Transcriptional regulator
LWP59_20220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWP59_20225	COG1063	alcohol dehydrogenase
LWP59_20230	COG3469	chitinase activity
LWP59_20255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LWP59_20265	COG0477	Major facilitator Superfamily
LWP59_20270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LWP59_20270	COG1796	DNA polymerase
LWP59_20275	COG0459	protein refolding
LWP59_20280	COG1063	alcohol dehydrogenase
LWP59_20305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWP59_20325	COG2814	Major facilitator Superfamily
LWP59_20335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LWP59_20365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LWP59_20375	COG0439	Biotin carboxylase
LWP59_20380	COG2201	protein-glutamate methylesterase activity
LWP59_20400	COG0393	Putative heavy-metal-binding
LWP59_20410	COG1414	Transcriptional regulator
LWP59_20435	COG2814	Major facilitator Superfamily
LWP59_20450	COG1940	carbohydrate kinase activity
LWP59_20460	COG1175	transmembrane transport
LWP59_20465	COG0395	ABC-type sugar transport system, permease component
LWP59_20470	COG2723	6-phospho-beta-galactosidase activity
LWP59_20480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LWP59_20485	COG1609	Transcriptional regulator
LWP59_20490	COG2814	Major facilitator Superfamily
LWP59_20495	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_20505	COG2814	Major facilitator Superfamily
LWP59_20515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWP59_20525	COG0531	amino acid
LWP59_20530	COG0488	(ABC) transporter
LWP59_20590	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_20595	COG1301	dicarboxylic acid transport
LWP59_20600	COG3285	dna ligase
LWP59_20600	COG1793	dna ligase
LWP59_20610	COG1733	regulation of RNA biosynthetic process
LWP59_20650	COG1024	Enoyl-CoA hydratase
LWP59_20695	COG1846	Transcriptional regulator
LWP59_20725	COG1960	acyl-CoA dehydrogenase activity
LWP59_20730	COG1960	acyl-CoA dehydrogenase activity
LWP59_20735	COG1960	acyl-CoA dehydrogenase activity
LWP59_20740	COG1309	transcriptional regulator
LWP59_20745	COG1584	GPR1 FUN34 yaaH family protein
LWP59_20750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWP59_20755	COG3275	phosphorelay sensor kinase activity
LWP59_20760	COG3279	Response regulator of the LytR AlgR family
LWP59_20770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_20780	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_20785	COG1309	transcriptional regulator
LWP59_20790	COG0596	Alpha beta hydrolase
LWP59_20815	COG1309	transcriptional regulator
LWP59_20820	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_20835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LWP59_20840	COG1960	acyl-CoA dehydrogenase activity
LWP59_20855	COG1024	Enoyl-CoA hydratase
LWP59_20860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWP59_20860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LWP59_20865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWP59_20890	COG1316	TRANSCRIPTIONal
LWP59_20905	COG1132	(ABC) transporter
LWP59_20920	COG0488	(ABC) transporter
LWP59_20930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LWP59_20935	COG2203	Gaf domain
LWP59_20935	COG3706	GGDEF domain
LWP59_20935	COG4251	negative regulation of phosphorylation
LWP59_20935	COG5001	Diguanylate cyclase
LWP59_20945	COG2151	metal-sulfur cluster biosynthetic enzyme
LWP59_20950	COG0822	iron-sulfur transferase activity
LWP59_20960	COG0396	ATPase activity
LWP59_21020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LWP59_21025	COG1657	PFAM Prenyltransferase squalene oxidase
LWP59_21035	COG1233	COG1233 Phytoene dehydrogenase and related
LWP59_21050	COG3835	regulator
LWP59_21065	COG0697	spore germination
LWP59_21070	COG0300	oxidoreductase activity
LWP59_21080	COG3973	AAA domain
LWP59_21085	COG0109	protoheme IX farnesyltransferase activity
LWP59_21095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LWP59_21100	COG0166	Belongs to the GPI family
LWP59_21100	COG0166	Belongs to the GPI family
LWP59_21115	COG0363	glucosamine-6-phosphate deaminase activity
LWP59_21120	COG3850	Histidine kinase
LWP59_21135	COG0149	triose-phosphate isomerase activity
LWP59_21140	COG0126	phosphoglycerate kinase activity
LWP59_21145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LWP59_21155	COG1280	lysine exporter protein (LysE YggA)
LWP59_21195	COG0463	Glycosyl transferase, family 2
LWP59_21220	COG1481	regulation of sporulation
LWP59_21225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LWP59_21230	COG1660	Displays ATPase and GTPase activities
LWP59_21235	COG0322	excinuclease ABC activity
LWP59_21240	COG0708	Exodeoxyribonuclease III
LWP59_21250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LWP59_21255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_21255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_21280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LWP59_21295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LWP59_21305	COG1758	RNA polymerase activity
LWP59_21310	COG0194	GDP metabolic process
LWP59_21320	COG0284	orotidine-5'-phosphate decarboxylase activity
LWP59_21330	COG0505	Belongs to the CarA family
LWP59_21345	COG0540	Belongs to the ATCase OTCase family
LWP59_21350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LWP59_21360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LWP59_21365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LWP59_21370	COG0006	proline dipeptidase activity
LWP59_21385	COG0346	lactoylglutathione lyase activity
LWP59_21390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LWP59_21395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LWP59_21400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LWP59_21405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LWP59_21410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LWP59_21440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWP59_21445	COG2188	Transcriptional regulator
LWP59_21450	COG1263	PTS System
LWP59_21465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LWP59_21475	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LWP59_21480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LWP59_21485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LWP59_21495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LWP59_21510	COG2084	Dehydrogenase
LWP59_21515	COG4221	oxidoreductase activity
LWP59_21520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LWP59_21545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LWP59_21555	COG0640	Transcriptional regulator
LWP59_21570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_21590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWP59_21605	COG0386	Belongs to the glutathione peroxidase family
LWP59_21625	COG3250	beta-galactosidase activity
LWP59_21640	COG1414	Transcriptional regulator
LWP59_21655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWP59_21660	COG1609	Transcriptional regulator
LWP59_21700	COG1414	Transcriptional regulator
LWP59_21720	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_21735	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_21745	COG2814	Major facilitator Superfamily
LWP59_21760	COG2018	Roadblock/LC7 domain
LWP59_21785	COG1742	UPF0060 membrane protein
LWP59_21790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWP59_21795	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_21815	COG0596	Alpha beta hydrolase
LWP59_21830	COG4214	carbohydrate transport
LWP59_21840	COG4213	ABC transporter substrate-binding protein
LWP59_21845	COG0583	DNA-binding transcription factor activity
LWP59_21850	COG0405	Gamma-glutamyltransferase
LWP59_21865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWP59_21900	COG2186	Transcriptional regulator
LWP59_21910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LWP59_21920	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_21930	COG1809	phosphosulfolactate synthase activity
LWP59_21960	COG0009	L-threonylcarbamoyladenylate synthase
LWP59_22005	COG2353	YceI-like domain
LWP59_22040	COG3852	Histidine kinase
LWP59_22075	COG4221	oxidoreductase activity
LWP59_22090	COG2315	Protein conserved in bacteria
LWP59_22110	COG0519	Catalyzes the synthesis of GMP from XMP
LWP59_22115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LWP59_22120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LWP59_22120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LWP59_22140	COG0583	DNA-binding transcription factor activity
LWP59_22145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LWP59_22150	COG0823	Involved in the tonB-independent uptake of proteins
LWP59_22150	COG1506	peptidase
LWP59_22150	COG4946	Tricorn protease homolog
LWP59_22155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWP59_22160	COG0765	amino acid transport
LWP59_22165	COG1126	abc transporter atp-binding protein
LWP59_22250	COG1414	Transcriptional regulator
LWP59_22255	COG2814	Major facilitator Superfamily
LWP59_22345	COG1414	Transcriptional regulator
LWP59_22370	COG0402	S-adenosylhomocysteine deaminase activity
LWP59_22380	COG3511	phospholipase C
LWP59_22410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWP59_22425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_22450	COG0697	spore germination
LWP59_22460	COG1842	Phage shock protein A
LWP59_22500	COG1063	alcohol dehydrogenase
LWP59_22535	COG0583	DNA-binding transcription factor activity
LWP59_22540	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_22555	COG1764	response to oxidative stress
LWP59_22575	COG0477	Major facilitator Superfamily
LWP59_22590	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LWP59_22600	COG3033	Beta-eliminating lyase
LWP59_22615	COG2018	Roadblock/LC7 domain
LWP59_22630	COG0667	Aldo Keto reductase
LWP59_22635	COG1104	cysteine desulfurase activity
LWP59_22640	COG2318	DinB family
LWP59_22645	COG0747	negative chemotaxis
LWP59_22650	COG2197	response regulator
LWP59_22675	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_22725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LWP59_22730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LWP59_22735	COG1609	Transcriptional regulator
LWP59_22780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LWP59_22805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWP59_22810	COG1309	transcriptional regulator
LWP59_22815	COG0477	Major facilitator Superfamily
LWP59_22840	COG0745	RESPONSE REGULATOR receiver
LWP59_22845	COG2205	protein histidine kinase activity
LWP59_22850	COG0586	Pfam SNARE associated Golgi protein
LWP59_22855	COG1968	undecaprenyl-diphosphatase activity
LWP59_22885	COG3629	intracellular signal transduction
LWP59_22885	COG3903	Transcriptional regulator
LWP59_22970	COG2814	Major facilitator Superfamily
LWP59_22990	COG2233	PERMEase
LWP59_23010	COG0604	alcohol dehydrogenase
LWP59_23010	COG3321	synthase
LWP59_23010	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_23015	COG1024	Enoyl-CoA hydratase
LWP59_23055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_23065	COG1116	anion transmembrane transporter activity
LWP59_23070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWP59_23090	COG1214	PFAM Peptidase M22, glycoprotease
LWP59_23090	COG0456	acetyltransferase
LWP59_23100	COG0583	DNA-binding transcription factor activity
LWP59_23145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LWP59_23150	COG2271	Major facilitator Superfamily
LWP59_23155	COG1335	isochorismatase
LWP59_23160	COG2814	Major facilitator Superfamily
LWP59_23170	COG2267	carboxylic ester hydrolase activity
LWP59_23175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LWP59_23220	COG1024	Enoyl-CoA hydratase
LWP59_23230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LWP59_23235	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_23255	COG1686	Belongs to the peptidase S11 family
LWP59_23260	COG2205	protein histidine kinase activity
LWP59_23265	COG0745	RESPONSE REGULATOR receiver
LWP59_23280	COG2186	Transcriptional regulator
LWP59_23285	COG2159	amidohydrolase
LWP59_23290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LWP59_23300	COG1663	tetraacyldisaccharide 4'-kinase activity
LWP59_23310	COG2267	carboxylic ester hydrolase activity
LWP59_23315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LWP59_23350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWP59_23360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWP59_23370	COG2814	Major facilitator Superfamily
LWP59_23375	COG3842	ATPase activity
LWP59_23380	COG1178	ABC-type Fe3 transport system permease component
LWP59_23405	COG0235	Class ii aldolase
LWP59_23475	COG2814	Major facilitator Superfamily
LWP59_23475	COG0477	Major facilitator Superfamily
LWP59_23485	COG2828	Protein conserved in bacteria
LWP59_23505	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LWP59_23515	COG2207	Transcriptional regulator
LWP59_23520	COG0667	Aldo Keto reductase
LWP59_23525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LWP59_23530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LWP59_23560	COG2018	Roadblock/LC7 domain
LWP59_23570	COG1959	2 iron, 2 sulfur cluster binding
LWP59_23580	COG1335	isochorismatase
LWP59_23595	COG0277	FAD linked oxidase domain protein
LWP59_23595	COG0247	lactate metabolic process
LWP59_23605	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_23610	COG1063	alcohol dehydrogenase
LWP59_23615	COG3387	PFAM Glycoside hydrolase 15-related
LWP59_23625	COG2188	Transcriptional regulator
LWP59_23645	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_23655	COG1024	Enoyl-CoA hydratase
LWP59_23675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWP59_23675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWP59_23680	COG1620	l-lactate permease
LWP59_23690	COG2186	Transcriptional regulator
LWP59_23695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LWP59_23700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LWP59_23735	COG3395	kinase activity
LWP59_23740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LWP59_23750	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LWP59_23770	COG0640	Transcriptional regulator
LWP59_23775	COG0640	Transcriptional regulator
LWP59_23780	COG1024	Enoyl-CoA hydratase
LWP59_23785	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWP59_23790	COG0022	dehydrogenase e1 component
LWP59_23795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LWP59_23860	COG1960	acyl-CoA dehydrogenase activity
LWP59_23865	COG1960	acyl-CoA dehydrogenase activity
LWP59_23870	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_23875	COG1024	Enoyl-CoA hydratase
LWP59_23880	COG1024	Enoyl-CoA hydratase
LWP59_23890	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_23895	COG1024	Enoyl-CoA hydratase
LWP59_23900	COG1960	acyl-CoA dehydrogenase activity
LWP59_23905	COG1960	acyl-CoA dehydrogenase activity
LWP59_23915	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_23930	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_23945	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_23955	COG0300	oxidoreductase activity
LWP59_23990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_24010	COG1024	Enoyl-CoA hydratase
LWP59_24015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LWP59_24080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_24085	COG2188	Transcriptional regulator
LWP59_24130	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_24145	COG1960	acyl-CoA dehydrogenase activity
LWP59_24150	COG2814	Major facilitator Superfamily
LWP59_24155	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_24160	COG0183	Belongs to the thiolase family
LWP59_24165	COG0427	acetyl-CoA hydrolase
LWP59_24170	COG1960	acyl-CoA dehydrogenase activity
LWP59_24180	COG1960	acyl-CoA dehydrogenase activity
LWP59_24190	COG1960	acyl-CoA dehydrogenase activity
LWP59_24210	COG1309	transcriptional regulator
LWP59_24220	COG1024	Enoyl-CoA hydratase
LWP59_24240	COG5000	phosphorelay sensor kinase activity
LWP59_24245	COG2188	Transcriptional regulator
LWP59_24255	COG1024	Enoyl-CoA hydratase
LWP59_24280	COG1960	acyl-CoA dehydrogenase activity
LWP59_24295	COG1946	Acyl-CoA thioesterase
LWP59_24300	COG1960	acyl-CoA dehydrogenase activity
LWP59_24305	COG1960	acyl-CoA dehydrogenase activity
LWP59_24310	COG1024	Enoyl-CoA hydratase
LWP59_24325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_24360	COG1024	Enoyl-CoA hydratase
LWP59_24380	COG1024	Enoyl-CoA hydratase
LWP59_24395	COG1960	acyl-CoA dehydrogenase activity
LWP59_24400	COG1960	acyl-CoA dehydrogenase activity
LWP59_24405	COG1960	acyl-CoA dehydrogenase activity
LWP59_24410	COG0183	Belongs to the thiolase family
LWP59_24415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_24425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_24440	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_24455	COG0542	response to heat
LWP59_24460	COG1024	Enoyl-CoA hydratase
LWP59_24470	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWP59_24475	COG0247	lactate metabolic process
LWP59_24475	COG0277	FAD linked oxidase domain protein
LWP59_24485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LWP59_24495	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_24500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LWP59_24525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LWP59_24530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_24535	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_24540	COG0778	Nitroreductase
LWP59_24555	COG1116	anion transmembrane transporter activity
LWP59_24560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWP59_24565	COG2391	methyltransferase activity
LWP59_24590	COG1595	DNA-templated transcription, initiation
LWP59_24595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWP59_24625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWP59_24630	COG0277	FAD linked oxidase domain protein
LWP59_24635	COG0277	FAD linked oxidase domain protein
LWP59_24640	COG0247	lactate metabolic process
LWP59_24645	COG1620	l-lactate permease
LWP59_24690	COG1105	Belongs to the carbohydrate kinase PfkB family
LWP59_24695	COG1349	DNA-binding transcription factor activity
LWP59_24705	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWP59_24715	COG1070	Carbohydrate kinase
LWP59_24760	COG0477	Major facilitator Superfamily
LWP59_24765	COG0167	dihydroorotate dehydrogenase activity
LWP59_24780	COG0514	ATP-dependent DNA helicase (RecQ)
LWP59_24785	COG0514	ATP-dependent DNA helicase (RecQ)
LWP59_24800	COG2814	Major facilitator Superfamily
LWP59_24810	COG0039	L-malate dehydrogenase activity
LWP59_24820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_24835	COG1309	transcriptional regulator
LWP59_24875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LWP59_24905	COG0604	alcohol dehydrogenase
LWP59_24920	COG1620	l-lactate permease
LWP59_24925	COG1063	alcohol dehydrogenase
LWP59_24975	COG2169	Transcriptional regulator
LWP59_24975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LWP59_24985	COG3663	DNA glycosylase
LWP59_24990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LWP59_25020	COG1309	transcriptional regulator
LWP59_25025	COG0542	response to heat
LWP59_25065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LWP59_25075	COG3226	Transcriptional regulator
LWP59_25080	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_25085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LWP59_25090	COG2124	cytochrome p450
LWP59_25115	COG4585	Histidine kinase
LWP59_25120	COG2197	response regulator
LWP59_25125	COG0154	amidase activity
LWP59_25135	COG0702	epimerase
LWP59_25155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWP59_25165	COG1595	DNA-templated transcription, initiation
LWP59_25180	COG1595	DNA-templated transcription, initiation
LWP59_25185	COG1942	4-Oxalocrotonate Tautomerase
LWP59_25205	COG4585	Histidine kinase
LWP59_25220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LWP59_25230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LWP59_25230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LWP59_25235	COG0667	Aldo Keto reductase
LWP59_25255	COG0667	Aldo Keto reductase
LWP59_25285	COG2201	protein-glutamate methylesterase activity
LWP59_25290	COG4585	Histidine kinase
LWP59_25295	COG2197	response regulator
LWP59_25305	COG0515	serine threonine protein kinase
LWP59_25340	COG1960	acyl-CoA dehydrogenase activity
LWP59_25365	COG3384	dioxygenase
LWP59_25390	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_25400	COG2909	trisaccharide binding
LWP59_25415	COG0633	Ferredoxin
LWP59_25465	COG1733	regulation of RNA biosynthetic process
LWP59_25470	COG1414	Transcriptional regulator
LWP59_25485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LWP59_25490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LWP59_25500	COG0800	Aldolase
LWP59_25505	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_25530	COG0693	protein deglycase activity
LWP59_25540	COG2186	Transcriptional regulator
LWP59_25550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_25550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_25560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LWP59_25565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_25580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_25630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_25650	COG4191	Histidine kinase
LWP59_25655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWP59_25660	COG0492	ferredoxin-NADP+ reductase activity
LWP59_25665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LWP59_25670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWP59_25700	COG1063	alcohol dehydrogenase
LWP59_25715	COG1960	acyl-CoA dehydrogenase activity
LWP59_25720	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_25725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_25730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LWP59_25780	COG0438	transferase activity, transferring glycosyl groups
LWP59_25795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWP59_25825	COG0542	response to heat
LWP59_25840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LWP59_25845	COG0443	Heat shock 70 kDa protein
LWP59_25915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LWP59_25935	COG0662	Cupin 2, conserved barrel domain protein
LWP59_25935	COG2207	Transcriptional regulator
LWP59_25945	COG2151	metal-sulfur cluster biosynthetic enzyme
LWP59_25975	COG3350	monooxygenase activity
LWP59_26005	COG0346	lactoylglutathione lyase activity
LWP59_26010	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_26025	COG0145	ligase activity
LWP59_26035	COG1309	transcriptional regulator
LWP59_26045	COG0183	Belongs to the thiolase family
LWP59_26050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_26060	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_26090	COG4829	muconolactone delta-isomerase
LWP59_26095	COG3485	protocatechuate 3,4-dioxygenase
LWP59_26135	COG0583	DNA-binding transcription factor activity
LWP59_26145	COG0154	amidase activity
LWP59_26185	COG1063	alcohol dehydrogenase
LWP59_26210	COG2801	Transposase and inactivated derivatives
LWP59_26220	COG0367	asparagine synthase
LWP59_26245	COG2018	Roadblock/LC7 domain
LWP59_26260	COG1830	Aldolase
LWP59_26265	COG1063	alcohol dehydrogenase
LWP59_26270	COG1349	DNA-binding transcription factor activity
LWP59_26280	COG2814	Major facilitator Superfamily
LWP59_26290	COG3180	Ammonia monooxygenase
LWP59_26295	COG0367	asparagine synthase
LWP59_26310	COG0748	coenzyme F420 binding
LWP59_26375	COG4211	Belongs to the binding-protein-dependent transport system permease family
LWP59_26430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LWP59_26445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWP59_26455	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_26495	COG0633	Ferredoxin
LWP59_26560	COG1127	ABC transporter
LWP59_26565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_26575	COG2197	response regulator
LWP59_26580	COG1960	acyl-CoA dehydrogenase activity
LWP59_26585	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_26595	COG1024	Enoyl-CoA hydratase
LWP59_26640	COG1595	DNA-templated transcription, initiation
LWP59_26660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWP59_26700	COG1127	ABC transporter
LWP59_26705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_26710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_26735	COG0702	epimerase
LWP59_26745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_26745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWP59_26775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LWP59_26780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_26785	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWP59_26805	COG1021	2,3-dihydroxybenzoate-AMP ligase
LWP59_26825	COG1960	acyl-CoA dehydrogenase activity
LWP59_26840	COG1309	transcriptional regulator
LWP59_26850	COG2814	Major facilitator Superfamily
LWP59_26890	COG1349	DNA-binding transcription factor activity
LWP59_26900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LWP59_26905	COG3457	Alanine racemase
LWP59_26945	COG3457	Alanine racemase
LWP59_26950	COG0531	amino acid
LWP59_26975	COG0604	alcohol dehydrogenase
LWP59_26995	COG3971	2-oxopent-4-enoate hydratase activity
LWP59_27000	COG3971	2-oxopent-4-enoate hydratase activity
LWP59_27005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LWP59_27010	COG2086	electron transfer activity
LWP59_27035	COG4638	Rieske (2fe-2S)
LWP59_27050	COG2267	carboxylic ester hydrolase activity
LWP59_27055	COG2368	4-hydroxyphenylacetate
LWP59_27090	COG2197	response regulator
LWP59_27100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWP59_27140	COG1127	ABC transporter
LWP59_27145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_27150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_27160	COG2197	response regulator
LWP59_27165	COG4191	Histidine kinase
LWP59_27200	COG2368	4-hydroxyphenylacetate
LWP59_27215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LWP59_27215	COG0596	Alpha beta hydrolase
LWP59_27235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LWP59_27250	COG1201	RNA secondary structure unwinding
LWP59_27285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LWP59_27300	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_27310	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_27365	COG0183	Belongs to the thiolase family
LWP59_27370	COG1024	Enoyl-CoA hydratase
LWP59_27385	COG2267	carboxylic ester hydrolase activity
LWP59_27430	COG0574	Belongs to the PEP-utilizing enzyme family
LWP59_27430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LWP59_27475	COG1609	Transcriptional regulator
LWP59_27500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LWP59_27595	COG1609	Transcriptional regulator
LWP59_27620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LWP59_27705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_27710	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_27735	COG2815	serine threonine protein kinase
LWP59_27735	COG0515	serine threonine protein kinase
LWP59_27775	COG0477	Major facilitator Superfamily
LWP59_27795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWP59_27815	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LWP59_27845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LWP59_27855	COG0477	Major facilitator Superfamily
LWP59_27865	COG0531	amino acid
LWP59_27870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LWP59_27885	COG0726	polysaccharide deacetylase
LWP59_27890	COG0477	Major facilitator Superfamily
LWP59_27895	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_27900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWP59_27915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWP59_27920	COG0596	Alpha beta hydrolase
LWP59_27920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LWP59_27955	COG2814	Major facilitator Superfamily
LWP59_27965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWP59_27970	COG2151	metal-sulfur cluster biosynthetic enzyme
LWP59_27975	COG3396	Phenylacetate-CoA oxygenase
LWP59_27980	COG3460	Phenylacetate-CoA oxygenase
LWP59_27985	COG3396	Phenylacetate-CoA oxygenase
LWP59_27990	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_27990	COG2030	dehydratase
LWP59_28005	COG1309	transcriptional regulator
LWP59_28060	COG2116	formate transmembrane transporter activity
LWP59_28125	COG0473	3-isopropylmalate dehydrogenase activity
LWP59_28130	COG1902	pentaerythritol trinitrate reductase activity
LWP59_28145	COG0477	Major facilitator Superfamily
LWP59_28155	COG3321	synthase
LWP59_28155	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_28155	COG0604	alcohol dehydrogenase
LWP59_28190	COG2208	phosphoserine phosphatase activity
LWP59_28190	COG2770	Histidine kinase
LWP59_28255	COG3012	SEC-C Motif Domain Protein
LWP59_28265	COG2072	flavoprotein involved in K transport
LWP59_28275	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_28305	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_28310	COG1846	Transcriptional regulator
LWP59_28315	COG1063	alcohol dehydrogenase
LWP59_28385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_28415	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_28445	COG0596	Alpha beta hydrolase
LWP59_28480	COG1366	Belongs to the anti-sigma-factor antagonist family
LWP59_28490	COG0702	epimerase
LWP59_28500	COG0174	glutamine synthetase
LWP59_28535	COG0640	Transcriptional regulator
LWP59_28550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWP59_28575	COG1793	dna ligase
LWP59_28590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_28605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWP59_28625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWP59_28630	COG3253	May function as heme-dependent peroxidase
LWP59_28640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LWP59_28650	COG2197	response regulator
LWP59_28660	COG0183	Belongs to the thiolase family
LWP59_28665	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWP59_28665	COG1024	Enoyl-CoA hydratase
LWP59_28680	COG0656	L-ascorbic acid biosynthetic process
LWP59_28690	COG2205	protein histidine kinase activity
LWP59_28695	COG0745	RESPONSE REGULATOR receiver
LWP59_28780	COG0768	penicillin binding
LWP59_28790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LWP59_28795	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_28810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LWP59_28815	COG0531	amino acid
LWP59_28820	COG0569	domain protein
LWP59_28850	COG0756	dUTP diphosphatase activity
LWP59_28870	COG0483	inositol monophosphate 1-phosphatase activity
LWP59_28885	COG0531	amino acid
LWP59_28895	COG0174	glutamine synthetase
LWP59_28930	COG2313	pseudouridylate synthase activity
LWP59_28950	COG2318	DinB family
LWP59_28965	COG1490	D-aminoacyl-tRNA deacylase activity
LWP59_28975	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LWP59_28975	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LWP59_28990	COG2070	2-Nitropropane dioxygenase
LWP59_29000	COG1024	Enoyl-CoA hydratase
LWP59_29010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LWP59_29020	COG1819	glycosyl
LWP59_29050	COG2124	cytochrome p450
LWP59_29055	COG0183	Belongs to the thiolase family
LWP59_29065	COG1733	regulation of RNA biosynthetic process
LWP59_29070	COG0702	epimerase
LWP59_29075	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_29085	COG1024	Enoyl-CoA hydratase
LWP59_29105	COG0596	Alpha beta hydrolase
LWP59_29110	COG0110	maltose O-acetyltransferase activity
LWP59_29120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_29130	COG1473	amidohydrolase
LWP59_29140	COG0183	Belongs to the thiolase family
LWP59_29145	COG1309	transcriptional regulator
LWP59_29150	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_29155	COG1960	acyl-CoA dehydrogenase activity
LWP59_29160	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_29165	COG1024	Enoyl-CoA hydratase
LWP59_29170	COG1960	acyl-CoA dehydrogenase activity
LWP59_29175	COG1960	acyl-CoA dehydrogenase activity
LWP59_29180	COG1960	acyl-CoA dehydrogenase activity
LWP59_29185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LWP59_29190	COG0346	lactoylglutathione lyase activity
LWP59_29195	COG2267	carboxylic ester hydrolase activity
LWP59_29200	COG1960	acyl-CoA dehydrogenase activity
LWP59_29210	COG1053	succinate dehydrogenase
LWP59_29230	COG2030	dehydratase
LWP59_29255	COG1960	acyl-CoA dehydrogenase activity
LWP59_29260	COG1960	acyl-CoA dehydrogenase activity
LWP59_29270	COG0657	acetylesterase activity
LWP59_29280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LWP59_29285	COG1960	acyl-CoA dehydrogenase activity
LWP59_29290	COG1309	transcriptional regulator
LWP59_29300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_29320	COG1703	isobutyryl-CoA mutase activity
LWP59_29320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWP59_29320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWP59_29335	COG2018	Roadblock/LC7 domain
LWP59_29350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWP59_29355	COG0019	diaminopimelate decarboxylase activity
LWP59_29365	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LWP59_29375	COG1566	PFAM secretion protein HlyD family protein
LWP59_29395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_29400	COG1960	acyl-CoA dehydrogenase activity
LWP59_29415	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_29420	COG1672	PFAM Archaeal ATPase
LWP59_29420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LWP59_29445	COG1946	Acyl-CoA thioesterase
LWP59_29470	COG2267	carboxylic ester hydrolase activity
LWP59_29495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LWP59_29520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LWP59_29525	COG1929	Belongs to the glycerate kinase type-1 family
LWP59_29530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWP59_29570	COG2890	protein-(glutamine-N5) methyltransferase activity
LWP59_29585	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LWP59_29590	COG0723	plastoquinol--plastocyanin reductase activity
LWP59_29625	COG1573	uracil-dna glycosylase
LWP59_29660	COG2080	2 iron, 2 sulfur cluster binding
LWP59_29665	COG2010	Cytochrome c
LWP59_29665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LWP59_29700	COG0644	oxidoreductase
LWP59_29705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LWP59_29715	COG1902	pentaerythritol trinitrate reductase activity
LWP59_29715	COG0446	pyridine nucleotide-disulphide oxidoreductase
LWP59_29725	COG0535	radical SAM domain protein
LWP59_29750	COG1940	carbohydrate kinase activity
LWP59_29780	COG1022	Amp-dependent synthetase and ligase
LWP59_29830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_29835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_29845	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_29860	COG1960	acyl-CoA dehydrogenase activity
LWP59_29865	COG1960	acyl-CoA dehydrogenase activity
LWP59_29870	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_29885	COG0123	including yeast histone deacetylase and acetoin utilization protein
LWP59_29895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LWP59_29915	COG4585	Histidine kinase
LWP59_29920	COG2197	response regulator
LWP59_29940	COG1505	serine-type exopeptidase activity
LWP59_29945	COG0702	epimerase
LWP59_29950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWP59_29955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LWP59_29965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LWP59_29975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LWP59_29995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LWP59_30005	COG1196	nuclear chromosome segregation
LWP59_30015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LWP59_30025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_30035	COG1802	Transcriptional regulator
LWP59_30040	COG0045	succinate-CoA ligase (ADP-forming) activity
LWP59_30075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LWP59_30080	COG2337	Toxic component of a toxin-antitoxin (TA) module
LWP59_30090	COG1126	abc transporter atp-binding protein
LWP59_30095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWP59_30100	COG0765	amino acid transport
LWP59_30105	COG0765	amino acid transport
LWP59_30110	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LWP59_30115	COG1940	carbohydrate kinase activity
LWP59_30135	COG1053	succinate dehydrogenase
LWP59_30155	COG0800	Aldolase
LWP59_30170	COG2137	regulation of response to DNA damage stimulus
LWP59_30175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LWP59_30185	COG0443	Heat shock 70 kDa protein
LWP59_30190	COG1201	RNA secondary structure unwinding
LWP59_30195	COG0242	peptide deformylase activity
LWP59_30245	COG0697	spore germination
LWP59_30265	COG0583	DNA-binding transcription factor activity
LWP59_30280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LWP59_30285	COG0142	geranyltranstransferase activity
LWP59_30315	COG0515	serine threonine protein kinase
LWP59_30315	COG2815	serine threonine protein kinase
LWP59_30330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LWP59_30335	COG2409	Drug exporters of the RND superfamily
LWP59_30345	COG0070	glutamate synthase
LWP59_30345	COG0067	glutamate synthase
LWP59_30345	COG0069	glutamate synthase activity
LWP59_30355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWP59_30360	COG1120	ATPase activity
LWP59_30365	COG4221	oxidoreductase activity
LWP59_30395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LWP59_30405	COG0159	tryptophan synthase activity
LWP59_30410	COG0133	tryptophan synthase activity
LWP59_30415	COG0134	indole-3-glycerol-phosphate synthase activity
LWP59_30425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LWP59_30430	COG1309	transcriptional regulator
LWP59_30450	COG0107	imidazoleglycerol-phosphate synthase activity
LWP59_30455	COG1309	transcriptional regulator
LWP59_30480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LWP59_30485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LWP59_30495	COG3958	Transketolase
LWP59_30500	COG3959	Transketolase, thiamine diphosphate binding domain
LWP59_30510	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LWP59_30520	COG1309	transcriptional regulator
LWP59_30525	COG2409	Drug exporters of the RND superfamily
LWP59_30540	COG0131	Imidazoleglycerol-phosphate dehydratase
LWP59_30545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWP59_30550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LWP59_30560	COG0697	spore germination
LWP59_30585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LWP59_30590	COG4585	Histidine kinase
LWP59_30600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LWP59_30605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LWP59_30615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LWP59_30630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LWP59_30635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LWP59_30640	COG0659	secondary active sulfate transmembrane transporter activity
LWP59_30645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LWP59_30650	COG2124	cytochrome p450
LWP59_30660	COG0438	transferase activity, transferring glycosyl groups
LWP59_30665	COG0791	NLP P60 protein
LWP59_30700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LWP59_30715	COG1845	cytochrome c oxidase, subunit III
LWP59_30735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LWP59_30745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LWP59_30755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWP59_30775	COG0667	Aldo Keto reductase
LWP59_30780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LWP59_30790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LWP59_30815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LWP59_30820	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWP59_30835	COG0321	lipoyl(octanoyl) transferase activity
LWP59_30860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LWP59_30865	COG0586	Pfam SNARE associated Golgi protein
LWP59_30870	COG3142	Participates in the control of copper homeostasis
LWP59_30885	COG1376	ErfK ybiS ycfS ynhG family protein
LWP59_30890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LWP59_30900	COG0477	Major facilitator Superfamily
LWP59_30910	COG0587	DNA-directed DNA polymerase activity
LWP59_30920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LWP59_30925	COG1472	Belongs to the glycosyl hydrolase 3 family
LWP59_30930	COG1609	Transcriptional regulator
LWP59_30940	COG1175	transmembrane transport
LWP59_30955	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LWP59_30975	COG0517	IMP dehydrogenase activity
LWP59_30975	COG4175	Glycine betaine
LWP59_30980	COG1414	Transcriptional regulator
LWP59_30985	COG2146	nitrite reductase [NAD(P)H] activity
LWP59_30990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWP59_30995	COG4638	Rieske (2fe-2S)
LWP59_31010	COG0656	L-ascorbic acid biosynthetic process
LWP59_31025	COG0583	DNA-binding transcription factor activity
LWP59_31045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LWP59_31055	COG1620	l-lactate permease
LWP59_31060	COG3201	nicotinamide mononucleotide transporter
LWP59_31080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LWP59_31125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LWP59_31135	COG1309	transcriptional regulator
LWP59_31160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_31170	COG2197	response regulator
LWP59_31175	COG0432	Pfam Uncharacterised protein family UPF0047
LWP59_31190	COG0442	prolyl-tRNA aminoacylation
LWP59_31195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LWP59_31200	COG3903	Transcriptional regulator
LWP59_31200	COG3629	intracellular signal transduction
LWP59_31210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LWP59_31235	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWP59_31250	COG4221	oxidoreductase activity
LWP59_31270	COG0542	response to heat
LWP59_31295	COG0183	Belongs to the thiolase family
LWP59_31300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_31325	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_31360	COG1404	Belongs to the peptidase S8 family
LWP59_31370	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_31380	COG1643	Atp-dependent helicase
LWP59_31390	COG2814	Major facilitator Superfamily
LWP59_31405	COG1120	ATPase activity
LWP59_31410	COG2186	Transcriptional regulator
LWP59_31415	COG1760	l-serine dehydratase
LWP59_31420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LWP59_31425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LWP59_31425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LWP59_31435	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_31520	COG0746	molybdenum cofactor guanylyltransferase activity
LWP59_31525	COG1414	Transcriptional regulator
LWP59_31530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWP59_31535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LWP59_31545	COG3485	protocatechuate 3,4-dioxygenase
LWP59_31550	COG3485	protocatechuate 3,4-dioxygenase
LWP59_31555	COG0183	Belongs to the thiolase family
LWP59_31560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LWP59_31565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LWP59_31620	COG3268	Saccharopine dehydrogenase
LWP59_31665	COG0247	lactate metabolic process
LWP59_31665	COG0277	FAD linked oxidase domain protein
LWP59_31670	COG3971	2-oxopent-4-enoate hydratase activity
LWP59_31690	COG0067	glutamate synthase
LWP59_31690	COG0069	glutamate synthase activity
LWP59_31690	COG0070	glutamate synthase
LWP59_31700	COG0697	spore germination
LWP59_31720	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_31725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LWP59_31745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LWP59_31760	COG1349	DNA-binding transcription factor activity
LWP59_31765	COG1492	cobalamin metabolic process
LWP59_31770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LWP59_31780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LWP59_31785	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LWP59_31790	COG2186	Transcriptional regulator
LWP59_31800	COG0531	amino acid
LWP59_31810	COG1797	cobyrinic acid a,c-diamide synthase activity
LWP59_31845	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LWP59_31855	COG0778	Nitroreductase
LWP59_31885	COG1131	(ABC) transporter
LWP59_31895	COG1476	TRANSCRIPTIONal
LWP59_31915	COG0745	RESPONSE REGULATOR receiver
LWP59_31930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LWP59_31960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWP59_31965	COG0163	prenyltransferase activity
LWP59_31975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LWP59_31990	COG2183	response to ionizing radiation
LWP59_32010	COG1522	sequence-specific DNA binding
LWP59_32020	COG2268	Band 7 protein
LWP59_32040	COG0277	FAD linked oxidase domain protein
LWP59_32065	COG1725	Transcriptional regulator
LWP59_32070	COG0515	serine threonine protein kinase
LWP59_32070	COG2815	serine threonine protein kinase
LWP59_32085	COG2226	methyltransferase
LWP59_32095	COG1119	ATPase activity
LWP59_32110	COG0058	SHG alpha-glucan phosphorylase activity
LWP59_32130	COG1846	Transcriptional regulator
LWP59_32140	COG3537	Alpha-1,2-mannosidase
LWP59_32145	COG3537	Alpha-1,2-mannosidase
LWP59_32150	COG1609	Transcriptional regulator
LWP59_32170	COG1879	ABC-type sugar transport system periplasmic component
LWP59_32180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWP59_32185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWP59_32195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LWP59_32195	COG0456	acetyltransferase
LWP59_32205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LWP59_32215	COG0183	Belongs to the thiolase family
LWP59_32220	COG0346	lactoylglutathione lyase activity
LWP59_32250	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LWP59_32255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LWP59_32270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LWP59_32280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWP59_32285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LWP59_32305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWP59_32310	COG2814	Major facilitator Superfamily
LWP59_32315	COG2188	Transcriptional regulator
LWP59_32320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_32325	COG1914	H( )-stimulated, divalent metal cation uptake system
LWP59_32330	COG4336	lyase activity
LWP59_32350	COG1136	(ABC) transporter
LWP59_32350	COG0577	efflux transmembrane transporter activity
LWP59_32365	COG4585	Histidine kinase
LWP59_32370	COG2197	response regulator
LWP59_32425	COG2072	flavoprotein involved in K transport
LWP59_32445	COG0477	Major facilitator Superfamily
LWP59_32465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LWP59_32465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LWP59_32475	COG2226	methyltransferase
LWP59_32500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWP59_32520	COG0366	Alpha amylase catalytic
LWP59_32530	COG0514	ATP-dependent DNA helicase (RecQ)
LWP59_32540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LWP59_32545	COG3844	kynureninase activity
LWP59_32555	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_32575	COG1316	TRANSCRIPTIONal
LWP59_32590	COG1309	transcriptional regulator
LWP59_32620	COG2828	Protein conserved in bacteria
LWP59_32625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LWP59_32655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LWP59_32665	COG1595	DNA-templated transcription, initiation
LWP59_32670	COG0583	DNA-binding transcription factor activity
LWP59_32675	COG1082	Xylose isomerase domain protein TIM barrel
LWP59_32675	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LWP59_32680	COG1309	transcriptional regulator
LWP59_32685	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_32710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWP59_32725	COG0484	heat shock protein binding
LWP59_32755	COG3340	Belongs to the peptidase S51 family
LWP59_32780	COG1414	Transcriptional regulator
LWP59_32795	COG0596	Alpha beta hydrolase
LWP59_32805	COG0655	NAD(P)H dehydrogenase (quinone) activity
LWP59_32820	COG0435	Glutathione S-transferase
LWP59_32835	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LWP59_32845	COG0477	Major facilitator Superfamily
LWP59_32850	COG0473	3-isopropylmalate dehydrogenase activity
LWP59_32860	COG0667	Aldo Keto reductase
LWP59_32875	COG3654	unkown
LWP59_32910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LWP59_32915	COG0473	3-isopropylmalate dehydrogenase activity
LWP59_32925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LWP59_32945	COG0028	Belongs to the TPP enzyme family
LWP59_32950	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWP59_32950	COG1024	Enoyl-CoA hydratase
LWP59_32955	COG0183	Belongs to the thiolase family
LWP59_32960	COG1309	transcriptional regulator
LWP59_32970	COG1960	acyl-CoA dehydrogenase activity
LWP59_32990	COG3903	Transcriptional regulator
LWP59_32990	COG3629	intracellular signal transduction
LWP59_32995	COG1960	acyl-CoA dehydrogenase activity
LWP59_33005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LWP59_33010	COG2755	lipolytic protein G-D-S-L family
LWP59_33025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LWP59_33040	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LWP59_33040	COG2508	Transcriptional regulator
LWP59_33055	COG0686	Belongs to the AlaDH PNT family
LWP59_33070	COG1132	(ABC) transporter
LWP59_33080	COG0277	FAD linked oxidase domain protein
LWP59_33085	COG0567	Dehydrogenase, E1 component
LWP59_33085	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWP59_33095	COG0517	IMP dehydrogenase activity
LWP59_33095	COG1125	glycine betaine transport
LWP59_33100	COG0281	malic enzyme
LWP59_33120	COG0406	alpha-ribazole phosphatase activity
LWP59_33140	COG1597	lipid kinase activity
LWP59_33160	COG1595	DNA-templated transcription, initiation
LWP59_33165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LWP59_33175	COG2135	peptidase activity
LWP59_33180	COG1162	GTPase activity
LWP59_33200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWP59_33205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LWP59_33215	COG0653	protein targeting
LWP59_33220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LWP59_33225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LWP59_33235	COG5000	phosphorelay sensor kinase activity
LWP59_33235	COG5002	protein histidine kinase activity
LWP59_33240	COG0745	RESPONSE REGULATOR receiver
LWP59_33260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LWP59_33275	COG0531	amino acid
LWP59_33285	COG1482	cell wall glycoprotein biosynthetic process
LWP59_33295	COG2835	tetraacyldisaccharide 4'-kinase activity
LWP59_33325	COG1994	Peptidase M50
LWP59_33340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LWP59_33355	COG0601	transmembrane transport
LWP59_33365	COG0747	negative chemotaxis
LWP59_33370	COG1217	gtp-binding protein TYPA
LWP59_33380	COG0180	Tryptophanyl-tRNA synthetase
LWP59_33395	COG0745	RESPONSE REGULATOR receiver
LWP59_33405	COG1131	(ABC) transporter
LWP59_33415	COG3842	ATPase activity
LWP59_33420	COG4149	molybdate abc transporter
LWP59_33430	COG2154	pterin-4-alpha-carbinolamine dehydratase
LWP59_33450	COG0012	GTP binding
LWP59_33465	COG0419	ATPase involved in DNA repair
LWP59_33470	COG0420	3'-5' exonuclease activity
LWP59_33485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LWP59_33500	COG1570	exodeoxyribonuclease VII activity
LWP59_33510	COG1722	exodeoxyribonuclease VII activity
LWP59_33525	COG0492	ferredoxin-NADP+ reductase activity
LWP59_33530	COG0114	fumarate hydratase activity
LWP59_33550	COG1793	dna ligase
LWP59_33565	COG2205	protein histidine kinase activity
LWP59_33570	COG0745	RESPONSE REGULATOR receiver
LWP59_33575	COG0667	Aldo Keto reductase
LWP59_33580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWP59_33595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LWP59_33625	COG1331	Highly conserved protein containing a thioredoxin domain
LWP59_33635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LWP59_33645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LWP59_33650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWP59_33660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LWP59_33695	COG0183	Belongs to the thiolase family
LWP59_33720	COG2814	Major facilitator Superfamily
LWP59_33735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWP59_33755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LWP59_33780	COG4941	Belongs to the sigma-70 factor family
LWP59_33800	COG3655	Transcriptional regulator
LWP59_33850	COG1196	nuclear chromosome segregation
LWP59_33885	COG1073	alpha beta
LWP59_33900	COG2188	Transcriptional regulator
LWP59_33965	COG1252	NADH dehydrogenase
LWP59_34010	COG0148	phosphopyruvate hydratase activity
LWP59_34040	COG0672	)-iron permease
LWP59_34050	COG2837	iron assimilation
LWP59_34075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_34085	COG2133	pyrroloquinoline quinone binding
LWP59_34125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LWP59_34150	COG0193	aminoacyl-tRNA hydrolase activity
LWP59_34160	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_34165	COG0488	(ABC) transporter
LWP59_34170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LWP59_34185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LWP59_34190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LWP59_34195	COG3583	domain protein
LWP59_34200	COG0084	hydrolase, TatD family'
LWP59_34205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWP59_34240	COG4565	transcriptional regulatory protein
LWP59_34245	COG3290	protein histidine kinase activity
LWP59_34290	COG0515	serine threonine protein kinase
LWP59_34330	COG0640	Transcriptional regulator
LWP59_34370	COG4977	sequence-specific DNA binding
LWP59_34395	COG0748	coenzyme F420 binding
LWP59_34450	COG2267	carboxylic ester hydrolase activity
LWP59_34465	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_34500	COG2818	Glycosylase
LWP59_34560	COG0582	viral genome integration into host DNA
LWP59_34590	COG2801	Transposase and inactivated derivatives
LWP59_34605	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LWP59_34610	COG3321	synthase
LWP59_34610	COG0604	alcohol dehydrogenase
LWP59_34795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWP59_34805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LWP59_34810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LWP59_34835	COG0521	Mo-molybdopterin cofactor biosynthetic process
LWP59_34835	COG0315	cyclic pyranopterin monophosphate synthase activity
LWP59_34845	COG5002	protein histidine kinase activity
LWP59_34850	COG0745	RESPONSE REGULATOR receiver
LWP59_34875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWP59_34885	COG1349	DNA-binding transcription factor activity
LWP59_34900	COG2197	response regulator
LWP59_34940	COG4638	Rieske (2fe-2S)
LWP59_34945	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LWP59_34975	COG3586	endonuclease activity
LWP59_34990	COG0525	valine-tRNA ligase activity
LWP59_35000	COG0022	dehydrogenase e1 component
LWP59_35005	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWP59_35010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LWP59_35015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWP59_35050	COG1234	tRNA 3'-trailer cleavage
LWP59_35055	COG3795	YCII-related domain
LWP59_35060	COG4941	Belongs to the sigma-70 factor family
LWP59_35090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWP59_35135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LWP59_35160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_35170	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWP59_35175	COG1960	acyl-CoA dehydrogenase activity
LWP59_35180	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LWP59_35180	COG5479	isomerase activity
LWP59_35200	COG1321	iron dependent repressor
LWP59_35215	COG1024	Enoyl-CoA hydratase
LWP59_35220	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_35250	COG1169	isochorismate synthase
LWP59_35275	COG1309	transcriptional regulator
LWP59_35310	COG4152	abc transporter atp-binding protein
LWP59_35315	COG1668	transmembrane transport
LWP59_35330	COG1309	transcriptional regulator
LWP59_35335	COG1960	acyl-CoA dehydrogenase activity
LWP59_35340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LWP59_35350	COG2017	converts alpha-aldose to the beta-anomer
LWP59_35355	COG1309	transcriptional regulator
LWP59_35375	COG3883	PFAM NLP P60 protein
LWP59_35375	COG0791	NLP P60 protein
LWP59_35390	COG0259	pyridoxamine-phosphate oxidase activity
LWP59_35395	COG0829	nickel cation binding
LWP59_35400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LWP59_35410	COG0804	urea catabolic process
LWP59_35415	COG0832	Belongs to the urease beta subunit family
LWP59_35420	COG0831	urea catabolic process
LWP59_35435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LWP59_35455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWP59_35465	COG5398	heme oxygenase
LWP59_35475	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LWP59_35485	COG2814	Major facilitator Superfamily
LWP59_35495	COG2252	PERMEase
LWP59_35520	COG2814	Major facilitator Superfamily
LWP59_35530	COG1278	Cold shock
LWP59_35550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWP59_35560	COG0318	PFAM AMP-dependent synthetase and ligase
LWP59_35565	COG0384	phenazine biosynthesis protein PhzF
LWP59_35570	COG3304	Inner membrane component domain
LWP59_35605	COG1846	Transcriptional regulator
LWP59_35620	COG1388	LysM domain
LWP59_35655	COG2018	Roadblock/LC7 domain
LWP59_35670	COG2018	Roadblock/LC7 domain
LWP59_35680	COG1116	anion transmembrane transporter activity
LWP59_35690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWP59_35695	COG1174	glycine betaine transport
LWP59_35715	COG1061	Type III restriction enzyme res subunit
LWP59_35740	COG0693	protein deglycase activity
LWP59_35745	COG1737	Transcriptional regulator
LWP59_35750	COG2195	Cleaves the N-terminal amino acid of tripeptides
LWP59_35755	COG1063	alcohol dehydrogenase
LWP59_35760	COG4948	Mandelate Racemase Muconate Lactonizing
LWP59_35775	COG0459	protein refolding
LWP59_35785	COG1278	Cold shock
LWP59_35800	COG2261	transglycosylase associated protein
LWP59_35810	COG0688	phosphatidylethanolamine metabolic process
LWP59_35820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LWP59_35835	COG0242	peptide deformylase activity
LWP59_35840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWP59_35850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LWP59_35855	COG0351	phosphomethylpyrimidine kinase
LWP59_35870	COG2022	thiamine diphosphate biosynthetic process
LWP59_35880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWP59_35880	COG2022	thiamine diphosphate biosynthetic process
LWP59_35885	COG0352	thiamine-phosphate diphosphorylase activity
LWP59_35895	COG0477	Major facilitator Superfamily
LWP59_35900	COG2188	Transcriptional regulator
LWP59_35905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LWP59_35910	COG2971	BadF BadG BcrA BcrD
LWP59_35925	COG2885	chlorophyll binding
LWP59_35925	COG3047	cAMP biosynthetic process
LWP59_35945	COG5285	phytanoyl-CoA dioxygenase
LWP59_35950	COG1917	Cupin 2, conserved barrel domain protein
LWP59_35960	COG0456	acetyltransferase
LWP59_35980	COG0400	carboxylic ester hydrolase activity
LWP59_35985	COG0346	lactoylglutathione lyase activity
LWP59_36030	COG1832	CoA-binding protein
LWP59_36035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LWP59_36065	COG0640	Transcriptional regulator
LWP59_36100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LWP59_36105	COG2847	Copper chaperone PCu(A)C
LWP59_36110	COG1329	Transcriptional regulator
LWP59_36115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LWP59_36130	COG0215	cysteine-tRNA ligase activity
LWP59_36135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWP59_36155	COG0531	amino acid
LWP59_36170	COG4399	Belongs to the UPF0754 family
LWP59_36185	COG3842	ATPase activity
LWP59_36190	COG0803	Belongs to the bacterial solute-binding protein 9 family
LWP59_36195	COG1609	Transcriptional regulator
LWP59_36205	COG1194	a g-specific adenine glycosylase
LWP59_36210	COG2267	carboxylic ester hydrolase activity
LWP59_36220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LWP59_36230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWP59_36255	COG0542	response to heat
LWP59_36270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LWP59_36280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LWP59_36285	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LWP59_36290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LWP59_36315	COG0789	Transcriptional regulator
LWP59_36330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LWP59_36345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LWP59_36375	COG0037	tRNA processing
LWP59_36385	COG2027	D-alanyl-D-alanine carboxypeptidase
LWP59_36390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LWP59_36395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LWP59_36420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LWP59_36425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LWP59_36440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LWP59_36440	COG1754	DNA topoisomerase type I activity
LWP59_36465	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LWP59_36470	COG1111	helicase
LWP59_36470	COG1205	dead DEAH box helicase
LWP59_36520	COG1472	Belongs to the glycosyl hydrolase 3 family
LWP59_36525	COG3876	Protein conserved in bacteria
LWP59_36530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LWP59_36535	COG1737	Transcriptional regulator
LWP59_36540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LWP59_36550	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LWP59_36555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWP59_36580	COG3104	oligopeptide transport
LWP59_36585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LWP59_36595	COG0596	Alpha beta hydrolase
LWP59_36635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWP59_36680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWP59_36685	COG1408	metallophosphoesterase
LWP59_36695	COG2226	methyltransferase
LWP59_36705	COG0745	RESPONSE REGULATOR receiver
LWP59_36710	COG2205	protein histidine kinase activity
LWP59_36720	COG0076	glutamate decarboxylase activity
LWP59_36725	COG0783	Belongs to the Dps family
LWP59_36730	COG1764	response to oxidative stress
LWP59_36740	COG0657	acetylesterase activity
LWP59_36765	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LWP59_36815	COG0583	DNA-binding transcription factor activity
LWP59_36820	COG0697	spore germination
LWP59_36830	COG4608	Belongs to the ABC transporter superfamily
LWP59_36835	COG0444	Belongs to the ABC transporter superfamily
LWP59_36840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWP59_36845	COG0601	transmembrane transport
LWP59_36850	COG0747	negative chemotaxis
LWP59_36855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LWP59_36855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LWP59_36860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LWP59_36865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LWP59_36870	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWP59_36885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LWP59_36895	COG2205	protein histidine kinase activity
LWP59_36900	COG0745	RESPONSE REGULATOR receiver
LWP59_36930	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LWP59_36950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LWP59_36960	COG3300	MHYT domain
LWP59_36960	COG5001	Diguanylate cyclase
LWP59_36975	COG2249	NAD(P)H dehydrogenase (quinone) activity
LWP59_37020	COG1609	Transcriptional regulator
LWP59_37075	COG1278	Cold shock
LWP59_37100	COG0515	serine threonine protein kinase
LWP59_37105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWP59_37120	COG0022	dehydrogenase e1 component
LWP59_37125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LWP59_37145	COG0028	Belongs to the TPP enzyme family
LWP59_37160	COG1132	(ABC) transporter
LWP59_37165	COG1132	(ABC) transporter
LWP59_37175	COG0515	serine threonine protein kinase
LWP59_37270	COG3547	Transposase (IS116 IS110 IS902 family)
LWP59_37335	COG4974	Belongs to the 'phage' integrase family
LWP59_37355	COG3103	Sh3 type 3 domain protein
LWP59_37355	COG0791	NLP P60 protein
LWP59_37355	COG1388	LysM domain
LWP59_37460	COG2255	four-way junction helicase activity
LWP59_37515	COG4974	Belongs to the 'phage' integrase family
LWP59_37625	COG1396	sequence-specific DNA binding
LWP59_37645	COG1011	Hydrolase
LWP59_37705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LWP59_37775	COG2132	Multicopper oxidase
LWP59_37815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWP59_37820	COG1141	Ferredoxin
LWP59_37840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWP59_37845	COG4221	oxidoreductase activity
LWP59_37870	COG0477	Major facilitator Superfamily
LWP59_37895	COG3344	reverse transcriptase
LWP59_37950	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LWP59_37955	COG4638	Rieske (2fe-2S)
LWP59_37995	COG2801	Transposase and inactivated derivatives
LWP59_38020	COG3344	reverse transcriptase
LWP59_38040	COG1063	alcohol dehydrogenase
LWP59_38045	COG2871	sodium ion transport
LWP59_38090	COG1414	Transcriptional regulator
LWP59_38095	COG2871	sodium ion transport
LWP59_38125	COG3971	2-oxopent-4-enoate hydratase activity
LWP59_38145	COG0574	Belongs to the PEP-utilizing enzyme family
LWP59_38145	COG3848	Pyruvate phosphate dikinase
LWP59_38160	COG1414	Transcriptional regulator
LWP59_38165	COG3971	2-oxopent-4-enoate hydratase activity
LWP59_38185	COG1942	4-Oxalocrotonate Tautomerase
LWP59_38205	COG4638	Rieske (2fe-2S)
LWP59_38270	COG2826	transposase and inactivated derivatives, IS30 family
LWP59_38355	COG4974	Belongs to the 'phage' integrase family
LWP59_38415	COG2826	transposase and inactivated derivatives, IS30 family
LWP59_38430	COG3344	reverse transcriptase
LWP59_38495	COG4974	Belongs to the 'phage' integrase family
LWP59_38530	COG1012	belongs to the aldehyde dehydrogenase family
LWP59_38540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LWP59_38545	COG0492	ferredoxin-NADP+ reductase activity
LWP59_38550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWP59_38565	COG2197	response regulator
LWP59_38570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWP59_38615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWP59_38640	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LWP59_38655	COG3261	NADH dehydrogenase
LWP59_38655	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LWP59_38660	COG0651	ATP synthesis coupled electron transport
LWP59_38675	COG0650	Formate hydrogenlyase subunit 4
LWP59_38685	COG3260	NADH ubiquinone oxidoreductase 20
LWP59_38735	COG0582	viral genome integration into host DNA
LWP59_38770	COG2188	Transcriptional regulator
LWP59_38775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LWP59_38810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWP59_38820	COG3718	enzyme involved in inositol metabolism
LWP59_38825	COG3962	Belongs to the TPP enzyme family
LWP59_38830	COG1082	Xylose isomerase domain protein TIM barrel
LWP59_38835	COG0673	inositol 2-dehydrogenase activity
LWP59_38845	COG0412	Dienelactone hydrolase
LWP59_38860	COG1473	amidohydrolase
LWP59_38875	COG1609	Transcriptional regulator
LWP59_38890	COG2186	Transcriptional regulator
LWP59_38900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWP59_38910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LWP59_38930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LWP59_39020	COG0717	Belongs to the dCTP deaminase family
LWP59_39025	COG0477	Major facilitator Superfamily
LWP59_39030	COG1960	acyl-CoA dehydrogenase activity
LWP59_39035	COG1309	transcriptional regulator
LWP59_39050	COG0247	lactate metabolic process
LWP59_39050	COG2181	nitrate reductase activity
LWP59_39055	COG2076	Multidrug Resistance protein
LWP59_39065	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LWP59_39080	COG0443	Heat shock 70 kDa protein
LWP59_39090	COG0484	heat shock protein binding
LWP59_39095	COG0789	Transcriptional regulator
LWP59_39125	COG0542	response to heat
LWP59_39135	COG4221	oxidoreductase activity
LWP59_39150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWP59_39185	COG1072	(Pantothenic acid kinase))
LWP59_39190	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_39205	COG0586	Pfam SNARE associated Golgi protein
LWP59_39225	COG3467	pyridoxamine 5'-phosphate
LWP59_39230	COG0277	FAD linked oxidase domain protein
LWP59_39235	COG0586	Pfam SNARE associated Golgi protein
LWP59_39260	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_39265	COG0667	Aldo Keto reductase
LWP59_39310	COG2124	cytochrome p450
LWP59_39335	COG5002	protein histidine kinase activity
LWP59_39345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LWP59_39370	COG0477	Major facilitator Superfamily
LWP59_39375	COG0584	glycerophosphoryl diester phosphodiesterase
LWP59_39410	COG3953	SLT domain
LWP59_39410	COG5280	Phage tail tape measure protein TP901
LWP59_39415	COG0436	Aminotransferase
LWP59_39450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LWP59_39460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LWP59_39480	COG1414	Transcriptional regulator
LWP59_39490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LWP59_39495	COG0047	phosphoribosylformylglycinamidine synthase activity
LWP59_39500	COG1132	(ABC) transporter
LWP59_39505	COG1132	(ABC) transporter
LWP59_39510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LWP59_39575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LWP59_39615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LWP59_39620	COG1984	allophanate hydrolase subunit 2
LWP59_39625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LWP59_39630	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LWP59_39660	COG0745	RESPONSE REGULATOR receiver
LWP59_39665	COG0456	acetyltransferase
LWP59_39665	COG0454	-acetyltransferase
LWP59_39685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LWP59_39715	COG4085	toxin activity
LWP59_39715	COG1525	nuclease
LWP59_39715	COG0737	Belongs to the 5'-nucleotidase family
LWP59_39725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LWP59_39740	COG2197	response regulator
LWP59_39745	COG1960	acyl-CoA dehydrogenase activity
LWP59_39770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LWP59_39785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWP59_39800	COG1309	transcriptional regulator
LWP59_39805	COG2030	dehydratase
LWP59_39810	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_39815	COG0183	Belongs to the thiolase family
LWP59_39875	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LWP59_39890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LWP59_39900	COG4585	Histidine kinase
LWP59_39905	COG2197	response regulator
LWP59_39910	COG1028	Short-chain dehydrogenase reductase Sdr
LWP59_39930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LWP59_39940	COG1136	(ABC) transporter
LWP59_39950	COG2197	response regulator
LWP59_39955	COG0402	S-adenosylhomocysteine deaminase activity
LWP59_39960	COG4221	oxidoreductase activity
LWP59_39970	COG2814	Major facilitator Superfamily
LWP59_39980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LWP59_39985	COG1309	transcriptional regulator
LWP59_39995	COG1695	Transcriptional regulator
LWP59_40005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWP59_40035	COG0360	Binds together with S18 to 16S ribosomal RNA
LWP59_40045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LWP59_40050	COG0359	binds to the 23S rRNA
LWP59_40085	COG3384	dioxygenase
LWP59_40105	COG2205	protein histidine kinase activity
LWP59_40110	COG2197	response regulator
LWP59_40120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LWP59_40130	COG0495	leucyl-tRNA aminoacylation
LWP59_40165	COG4585	Histidine kinase
LWP59_40170	COG0617	tRNA 3'-terminal CCA addition
LWP59_40195	COG1595	DNA-templated transcription, initiation
LWP59_40210	COG0492	ferredoxin-NADP+ reductase activity
LWP59_40210	COG3118	belongs to the thioredoxin family
LWP59_40215	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWP59_40215	COG3409	Peptidoglycan-binding domain 1 protein
LWP59_40230	COG1181	Belongs to the D-alanine--D-alanine ligase family
LWP59_40240	COG1192	Involved in chromosome partitioning
LWP59_40245	COG0357	Ribosomal RNA small subunit methyltransferase G
LWP59_40260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane