locus-tag	class	description
A4R43_00015	COG2080	2 iron, 2 sulfur cluster binding
A4R43_00045	COG2801	Transposase and inactivated derivatives
A4R43_00045	COG3415	Transposase
A4R43_00055	COG1414	Transcriptional regulator
A4R43_00085	COG2124	cytochrome p450
A4R43_00095	COG5001	Diguanylate cyclase
A4R43_00100	COG1309	transcriptional regulator
A4R43_00110	COG0740	serine-type endopeptidase activity
A4R43_00115	COG0456	acetyltransferase
A4R43_00160	COG4941	Belongs to the sigma-70 factor family
A4R43_00165	COG1959	2 iron, 2 sulfur cluster binding
A4R43_00185	COG0395	ABC-type sugar transport system, permease component
A4R43_00220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_00230	COG2079	MmgE PrpD family protein
A4R43_00240	COG2301	Belongs to the HpcH HpaI aldolase family
A4R43_00245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_00255	COG0559	Belongs to the binding-protein-dependent transport system permease family
A4R43_00270	COG0410	ABC transporter
A4R43_00290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_00310	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_00315	COG1024	Enoyl-CoA hydratase
A4R43_00325	COG1024	Enoyl-CoA hydratase
A4R43_00330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R43_00340	COG2271	Major facilitator Superfamily
A4R43_00345	COG0745	RESPONSE REGULATOR receiver
A4R43_00350	COG2205	protein histidine kinase activity
A4R43_00425	COG1802	Transcriptional regulator
A4R43_00435	COG2376	Dihydroxyacetone kinase
A4R43_00440	COG0698	ribose 5-phosphate isomerase
A4R43_00445	COG0149	triose-phosphate isomerase activity
A4R43_00465	COG0583	DNA-binding transcription factor activity
A4R43_00565	COG2205	protein histidine kinase activity
A4R43_00570	COG0745	RESPONSE REGULATOR receiver
A4R43_00575	COG1113	amino acid transport
A4R43_00585	COG1695	Transcriptional regulator
A4R43_00605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4R43_00620	COG0025	NhaP-type Na H and K H
A4R43_00630	COG1595	DNA-templated transcription, initiation
A4R43_00635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_00650	COG0789	Transcriptional regulator
A4R43_00655	COG2084	Dehydrogenase
A4R43_00715	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A4R43_00785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_00825	COG2318	DinB family
A4R43_00855	COG2197	response regulator
A4R43_00875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A4R43_00885	COG0837	glucose binding
A4R43_00885	COG1737	Transcriptional regulator
A4R43_00920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R43_00930	COG4977	sequence-specific DNA binding
A4R43_00980	COG4978	Transcriptional regulator
A4R43_00980	COG0789	Transcriptional regulator
A4R43_00985	COG0583	DNA-binding transcription factor activity
A4R43_01030	COG5377	YqaJ viral recombinase family
A4R43_01035	COG3723	Recombinational DNA repair protein, rece pathway
A4R43_01295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_01340	COG2010	Cytochrome c
A4R43_01340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_01345	COG2080	2 iron, 2 sulfur cluster binding
A4R43_01375	COG2207	Transcriptional regulator
A4R43_01380	COG2223	nitrite transmembrane transporter activity
A4R43_01390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4R43_01390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4R43_01480	COG1309	transcriptional regulator
A4R43_01500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_01520	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_01530	COG0659	secondary active sulfate transmembrane transporter activity
A4R43_01535	COG0288	reversible hydration of carbon dioxide
A4R43_01550	COG1278	Cold shock
A4R43_01565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_01575	COG1733	regulation of RNA biosynthetic process
A4R43_01595	COG0640	Transcriptional regulator
A4R43_01625	COG1960	acyl-CoA dehydrogenase activity
A4R43_01650	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_01665	COG2814	Major facilitator Superfamily
A4R43_01685	COG0640	Transcriptional regulator
A4R43_01705	COG1309	transcriptional regulator
A4R43_01720	COG2315	Protein conserved in bacteria
A4R43_01730	COG0640	Transcriptional regulator
A4R43_01745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R43_01760	COG2226	methyltransferase
A4R43_01790	COG1802	Transcriptional regulator
A4R43_01795	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_01820	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A4R43_01840	COG1595	DNA-templated transcription, initiation
A4R43_01845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_01885	COG0640	Transcriptional regulator
A4R43_01895	COG0569	domain protein
A4R43_01900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4R43_01915	COG0574	Belongs to the PEP-utilizing enzyme family
A4R43_01915	COG3848	Pyruvate phosphate dikinase
A4R43_01955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_02030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R43_02055	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_02065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R43_02070	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R43_02075	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_02080	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_02090	COG2851	Citrate transporter
A4R43_02110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R43_02115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4R43_02120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R43_02125	COG1414	Transcriptional regulator
A4R43_02150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R43_02150	COG0515	serine threonine protein kinase
A4R43_02160	COG3415	Transposase
A4R43_02160	COG2801	Transposase and inactivated derivatives
A4R43_02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_02170	COG2188	Transcriptional regulator
A4R43_02190	COG3251	PFAM MbtH domain protein
A4R43_02195	COG1132	(ABC) transporter
A4R43_02200	COG1132	(ABC) transporter
A4R43_02310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A4R43_02390	COG0246	Mannitol dehydrogenase
A4R43_02395	COG0477	Major facilitator Superfamily
A4R43_02400	COG1063	alcohol dehydrogenase
A4R43_02410	COG1522	sequence-specific DNA binding
A4R43_02420	COG0667	Aldo Keto reductase
A4R43_02425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A4R43_02450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4R43_02465	COG0494	nUDIX hydrolase
A4R43_02490	COG0494	nUDIX hydrolase
A4R43_02525	COG0395	ABC-type sugar transport system, permease component
A4R43_02545	COG1522	sequence-specific DNA binding
A4R43_02580	COG2815	serine threonine protein kinase
A4R43_02580	COG0515	serine threonine protein kinase
A4R43_02595	COG0443	Heat shock 70 kDa protein
A4R43_02615	COG2205	protein histidine kinase activity
A4R43_02620	COG0745	RESPONSE REGULATOR receiver
A4R43_02625	COG2259	Doxx family
A4R43_02645	COG1309	transcriptional regulator
A4R43_02650	COG2080	2 iron, 2 sulfur cluster binding
A4R43_02655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R43_02660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_02665	COG0673	inositol 2-dehydrogenase activity
A4R43_02680	COG0463	Glycosyl transferase, family 2
A4R43_02695	COG0596	Alpha beta hydrolase
A4R43_02710	COG1115	amino acid carrier protein
A4R43_02715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R43_02720	COG1819	glycosyl
A4R43_02740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_02800	COG1063	alcohol dehydrogenase
A4R43_02805	COG0477	Major facilitator Superfamily
A4R43_02815	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_02885	COG1937	Protein conserved in bacteria
A4R43_02935	COG1073	alpha beta
A4R43_02945	COG0798	PFAM Bile acid sodium symporter
A4R43_02965	COG2072	flavoprotein involved in K transport
A4R43_02975	COG0640	Transcriptional regulator
A4R43_02980	COG0583	DNA-binding transcription factor activity
A4R43_02990	COG3485	protocatechuate 3,4-dioxygenase
A4R43_03005	COG0477	Major facilitator Superfamily
A4R43_03025	COG2807	transmembrane transport
A4R43_03030	COG0583	DNA-binding transcription factor activity
A4R43_03060	COG2070	2-Nitropropane dioxygenase
A4R43_03065	COG4221	oxidoreductase activity
A4R43_03110	COG2172	sigma factor antagonist activity
A4R43_03115	COG1366	Belongs to the anti-sigma-factor antagonist family
A4R43_03120	COG1366	Belongs to the anti-sigma-factor antagonist family
A4R43_03150	COG0477	Major facilitator Superfamily
A4R43_03175	COG1309	transcriptional regulator
A4R43_03190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_03265	COG1595	DNA-templated transcription, initiation
A4R43_03280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4R43_03330	COG1595	DNA-templated transcription, initiation
A4R43_03345	COG0583	DNA-binding transcription factor activity
A4R43_03350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_03375	COG2124	cytochrome p450
A4R43_03405	COG3629	intracellular signal transduction
A4R43_03405	COG3903	Transcriptional regulator
A4R43_03415	COG0300	oxidoreductase activity
A4R43_03420	COG0583	DNA-binding transcription factor activity
A4R43_03425	COG2226	methyltransferase
A4R43_03430	COG0477	Major facilitator Superfamily
A4R43_03445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_03455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4R43_03460	COG0277	FAD linked oxidase domain protein
A4R43_03460	COG0247	lactate metabolic process
A4R43_03465	COG3622	Belongs to the hyi family
A4R43_03470	COG2084	Dehydrogenase
A4R43_03475	COG3960	tartronate-semialdehyde synthase activity
A4R43_03535	COG0583	DNA-binding transcription factor activity
A4R43_03540	COG0667	Aldo Keto reductase
A4R43_03550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4R43_03555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_03590	COG1846	Transcriptional regulator
A4R43_03595	COG0697	spore germination
A4R43_03605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4R43_03610	COG0747	negative chemotaxis
A4R43_03625	COG0444	Belongs to the ABC transporter superfamily
A4R43_03630	COG4608	Belongs to the ABC transporter superfamily
A4R43_03640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R43_03645	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_03650	COG1414	Transcriptional regulator
A4R43_03660	COG1309	transcriptional regulator
A4R43_03670	COG1024	Enoyl-CoA hydratase
A4R43_03675	COG3903	Transcriptional regulator
A4R43_03675	COG3629	intracellular signal transduction
A4R43_03690	COG4585	Histidine kinase
A4R43_03690	COG2203	Gaf domain
A4R43_03705	COG3903	Transcriptional regulator
A4R43_03705	COG3629	intracellular signal transduction
A4R43_03710	COG0488	(ABC) transporter
A4R43_03725	COG0247	lactate metabolic process
A4R43_03730	COG0277	FAD linked oxidase domain protein
A4R43_03745	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_03755	COG1063	alcohol dehydrogenase
A4R43_03760	COG2188	Transcriptional regulator
A4R43_03765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_03770	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A4R43_03780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_03785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_03790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R43_03795	COG2080	2 iron, 2 sulfur cluster binding
A4R43_03800	COG1309	transcriptional regulator
A4R43_03815	COG2814	Major facilitator Superfamily
A4R43_03835	COG3540	Alkaline phosphatase
A4R43_03855	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_03885	COG2197	response regulator
A4R43_03895	COG0577	efflux transmembrane transporter activity
A4R43_03895	COG1136	(ABC) transporter
A4R43_03900	COG0577	efflux transmembrane transporter activity
A4R43_03915	COG0302	gtp cyclohydrolase
A4R43_03925	COG1120	ATPase activity
A4R43_03930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R43_03955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_03975	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R43_03975	COG0515	serine threonine protein kinase
A4R43_04015	COG1914	H( )-stimulated, divalent metal cation uptake system
A4R43_04020	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_04025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R43_04040	COG0667	Aldo Keto reductase
A4R43_04045	COG4608	Belongs to the ABC transporter superfamily
A4R43_04050	COG0444	Belongs to the ABC transporter superfamily
A4R43_04060	COG0601	transmembrane transport
A4R43_04075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4R43_04080	COG1349	DNA-binding transcription factor activity
A4R43_04085	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_04095	COG2746	aminoglycoside 3-N-acetyltransferase activity
A4R43_04100	COG1120	ATPase activity
A4R43_04125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_04140	COG2076	Multidrug Resistance protein
A4R43_04150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4R43_04155	COG0778	Nitroreductase
A4R43_04160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4R43_04185	COG1560	Kdo2-lipid A biosynthetic process
A4R43_04190	COG0438	transferase activity, transferring glycosyl groups
A4R43_04205	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A4R43_04235	COG3629	intracellular signal transduction
A4R43_04235	COG3903	Transcriptional regulator
A4R43_04245	COG2197	response regulator
A4R43_04255	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A4R43_04270	COG3903	Transcriptional regulator
A4R43_04270	COG3629	intracellular signal transduction
A4R43_04275	COG0640	Transcriptional regulator
A4R43_04305	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A4R43_04310	COG0217	transcriptional regulatory protein
A4R43_04320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4R43_04325	COG0632	four-way junction helicase activity
A4R43_04330	COG2255	four-way junction helicase activity
A4R43_04345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R43_04350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4R43_04355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R43_04360	COG1024	Enoyl-CoA hydratase
A4R43_04365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R43_04390	COG1414	Transcriptional regulator
A4R43_04410	COG4172	Belongs to the ABC transporter superfamily
A4R43_04415	COG0673	inositol 2-dehydrogenase activity
A4R43_04430	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_04465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4R43_04495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R43_04510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4R43_04530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4R43_04545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4R43_04550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4R43_04570	COG0275	rRNA processing
A4R43_04575	COG2124	cytochrome p450
A4R43_04595	COG2124	cytochrome p450
A4R43_04605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_04610	COG2190	(PTS) system
A4R43_04610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R43_04610	COG1263	PTS System
A4R43_04620	COG1263	PTS System
A4R43_04620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R43_04655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4R43_04660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4R43_04665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4R43_04670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4R43_04675	COG0346	lactoylglutathione lyase activity
A4R43_04690	COG0006	proline dipeptidase activity
A4R43_04695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4R43_04700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4R43_04715	COG0540	Belongs to the ATCase OTCase family
A4R43_04730	COG0505	Belongs to the CarA family
A4R43_04740	COG0284	orotidine-5'-phosphate decarboxylase activity
A4R43_04755	COG1758	RNA polymerase activity
A4R43_04765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4R43_04770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4R43_04780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_04785	COG0405	Gamma-glutamyltransferase
A4R43_04790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4R43_04820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_04820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_04845	COG0322	excinuclease ABC activity
A4R43_04850	COG1660	Displays ATPase and GTPase activities
A4R43_04855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4R43_04860	COG1481	regulation of sporulation
A4R43_04915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4R43_04920	COG0126	phosphoglycerate kinase activity
A4R43_04925	COG0149	triose-phosphate isomerase activity
A4R43_04940	COG3850	Histidine kinase
A4R43_04945	COG0363	glucosamine-6-phosphate deaminase activity
A4R43_04960	COG0166	Belongs to the GPI family
A4R43_04965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R43_04975	COG0109	protoheme IX farnesyltransferase activity
A4R43_04985	COG1733	regulation of RNA biosynthetic process
A4R43_04990	COG3973	AAA domain
A4R43_04995	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4R43_05005	COG0604	alcohol dehydrogenase
A4R43_05055	COG0396	ATPase activity
A4R43_05065	COG0822	iron-sulfur transferase activity
A4R43_05075	COG0504	CTP synthase activity
A4R43_05085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4R43_05090	COG4585	Histidine kinase
A4R43_05095	COG2197	response regulator
A4R43_05100	COG3447	MASE1 domain protein
A4R43_05100	COG5001	Diguanylate cyclase
A4R43_05100	COG5002	protein histidine kinase activity
A4R43_05120	COG0488	(ABC) transporter
A4R43_05135	COG1132	(ABC) transporter
A4R43_05150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_05155	COG1316	TRANSCRIPTIONal
A4R43_05165	COG5001	Diguanylate cyclase
A4R43_05165	COG3300	MHYT domain
A4R43_05175	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4R43_05180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_05185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_05185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4R43_05195	COG1024	Enoyl-CoA hydratase
A4R43_05215	COG1960	acyl-CoA dehydrogenase activity
A4R43_05235	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_05240	COG1309	transcriptional regulator
A4R43_05270	COG0596	Alpha beta hydrolase
A4R43_05280	COG1309	transcriptional regulator
A4R43_05285	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_05290	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_05295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_05305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R43_05310	COG1024	Enoyl-CoA hydratase
A4R43_05325	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_05330	COG1960	acyl-CoA dehydrogenase activity
A4R43_05335	COG1960	acyl-CoA dehydrogenase activity
A4R43_05365	COG2186	Transcriptional regulator
A4R43_05370	COG2197	response regulator
A4R43_05375	COG3903	Transcriptional regulator
A4R43_05375	COG3629	intracellular signal transduction
A4R43_05420	COG1793	dna ligase
A4R43_05420	COG3285	dna ligase
A4R43_05425	COG0704	Plays a role in the regulation of phosphate uptake
A4R43_05435	COG2197	response regulator
A4R43_05475	COG0542	response to heat
A4R43_05520	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_05525	COG1070	Carbohydrate kinase
A4R43_05530	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_05530	COG3347	Dehydrogenase
A4R43_05535	COG1609	Transcriptional regulator
A4R43_05575	COG4335	DNA alkylation repair
A4R43_05625	COG2124	cytochrome p450
A4R43_05635	COG0009	L-threonylcarbamoyladenylate synthase
A4R43_05650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_05660	COG0477	Major facilitator Superfamily
A4R43_05670	COG1131	(ABC) transporter
A4R43_05680	COG2197	response regulator
A4R43_05715	COG2271	Major facilitator Superfamily
A4R43_05720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_05760	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R43_05770	COG2084	Dehydrogenase
A4R43_05780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4R43_05785	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4R43_05800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_05820	COG0861	Integral membrane protein TerC family
A4R43_05830	COG1802	Transcriptional regulator
A4R43_05840	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_05855	COG3383	formate dehydrogenase (NAD+) activity
A4R43_05895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_05905	COG1414	Transcriptional regulator
A4R43_05925	COG0435	Glutathione S-transferase
A4R43_05955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_05960	COG0277	FAD linked oxidase domain protein
A4R43_05970	COG2124	cytochrome p450
A4R43_05985	COG1929	Belongs to the glycerate kinase type-1 family
A4R43_05990	COG3960	tartronate-semialdehyde synthase activity
A4R43_05995	COG2084	Dehydrogenase
A4R43_06000	COG3622	Belongs to the hyi family
A4R43_06010	COG2252	PERMEase
A4R43_06015	COG0590	tRNA wobble adenosine to inosine editing
A4R43_06020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_06040	COG3835	regulator
A4R43_06060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A4R43_06080	COG0028	Belongs to the TPP enzyme family
A4R43_06085	COG0583	DNA-binding transcription factor activity
A4R43_06095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R43_06100	COG1053	succinate dehydrogenase
A4R43_06110	COG0583	DNA-binding transcription factor activity
A4R43_06115	COG2040	homocysteine
A4R43_06135	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_06155	COG3706	GGDEF domain
A4R43_06155	COG0745	RESPONSE REGULATOR receiver
A4R43_06170	COG1846	Transcriptional regulator
A4R43_06205	COG2814	Major facilitator Superfamily
A4R43_06215	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_06230	COG2936	dipeptidyl-peptidase activity
A4R43_06235	COG0723	plastoquinol--plastocyanin reductase activity
A4R43_06260	COG0248	Ppx GppA phosphatase
A4R43_06280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_06285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R43_06290	COG2080	2 iron, 2 sulfur cluster binding
A4R43_06295	COG0693	protein deglycase activity
A4R43_06310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R43_06310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R43_06345	COG4209	transmembrane transport
A4R43_06350	COG0395	ABC-type sugar transport system, permease component
A4R43_06360	COG3415	Transposase
A4R43_06360	COG2801	Transposase and inactivated derivatives
A4R43_06390	COG1609	Transcriptional regulator
A4R43_06400	COG1175	transmembrane transport
A4R43_06405	COG0395	ABC-type sugar transport system, permease component
A4R43_06420	COG4733	cellulase activity
A4R43_06420	COG5297	Belongs to the glycosyl hydrolase family 6
A4R43_06445	COG3842	ATPase activity
A4R43_06450	COG2723	6-phospho-beta-galactosidase activity
A4R43_06455	COG0395	ABC-type sugar transport system, permease component
A4R43_06460	COG1175	transmembrane transport
A4R43_06490	COG1335	isochorismatase
A4R43_06540	COG1595	DNA-templated transcription, initiation
A4R43_06590	COG3265	gluconokinase activity
A4R43_06610	COG0477	Major facilitator Superfamily
A4R43_06640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4R43_06685	COG2124	cytochrome p450
A4R43_06710	COG5002	protein histidine kinase activity
A4R43_06720	COG1185	polyribonucleotide nucleotidyltransferase activity
A4R43_06765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_06775	COG0444	Belongs to the ABC transporter superfamily
A4R43_06785	COG0747	negative chemotaxis
A4R43_06790	COG2186	Transcriptional regulator
A4R43_06810	COG0583	DNA-binding transcription factor activity
A4R43_06830	COG0431	NADPH-dependent FMN reductase
A4R43_06830	COG3976	FMN-binding domain protein
A4R43_06830	COG1053	succinate dehydrogenase
A4R43_06835	COG1802	Transcriptional regulator
A4R43_06840	COG2356	endonuclease I
A4R43_06845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4R43_06845	COG3291	Pkd domain containing protein
A4R43_06905	COG2814	Major facilitator Superfamily
A4R43_06915	COG1253	flavin adenine dinucleotide binding
A4R43_06920	COG1253	flavin adenine dinucleotide binding
A4R43_06985	COG1522	sequence-specific DNA binding
A4R43_06990	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4R43_07005	COG1335	isochorismatase
A4R43_07020	COG1609	Transcriptional regulator
A4R43_07025	COG1175	transmembrane transport
A4R43_07050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_07065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_07075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_07095	COG3938	Belongs to the proline racemase family
A4R43_07105	COG1024	Enoyl-CoA hydratase
A4R43_07120	COG0667	Aldo Keto reductase
A4R43_07135	COG4585	Histidine kinase
A4R43_07140	COG2197	response regulator
A4R43_07150	COG0583	DNA-binding transcription factor activity
A4R43_07155	COG2814	Major facilitator Superfamily
A4R43_07165	COG0583	DNA-binding transcription factor activity
A4R43_07180	COG3401	FG-GAP repeat protein
A4R43_07245	COG4941	Belongs to the sigma-70 factor family
A4R43_07250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4R43_07275	COG2197	response regulator
A4R43_07285	COG1131	(ABC) transporter
A4R43_07340	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_07365	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_07395	COG1486	melibiose metabolic process
A4R43_07400	COG1349	DNA-binding transcription factor activity
A4R43_07405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_07410	COG1653	transport
A4R43_07420	COG0395	ABC-type sugar transport system, permease component
A4R43_07450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_07475	COG1088	dTDP-glucose 4,6-dehydratase activity
A4R43_07490	COG1215	transferase activity, transferring glycosyl groups
A4R43_07500	COG0438	transferase activity, transferring glycosyl groups
A4R43_07505	COG2192	nodulation
A4R43_07510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4R43_07515	COG0859	PFAM glycosyl transferase family 9
A4R43_07520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4R43_07525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4R43_07525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4R43_07530	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_07540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4R43_07550	COG0300	oxidoreductase activity
A4R43_07560	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_07575	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_07580	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_07605	COG3546	catalase activity
A4R43_07640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_07655	COG4585	Histidine kinase
A4R43_07660	COG2197	response regulator
A4R43_07665	COG0402	S-adenosylhomocysteine deaminase activity
A4R43_07670	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_07675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A4R43_07695	COG1064	alcohol dehydrogenase
A4R43_07700	COG1309	transcriptional regulator
A4R43_07740	COG2318	DinB family
A4R43_07760	COG0583	DNA-binding transcription factor activity
A4R43_07795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4R43_07815	COG0640	Transcriptional regulator
A4R43_07820	COG0583	DNA-binding transcription factor activity
A4R43_07830	COG4638	Rieske (2fe-2S)
A4R43_07860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_07865	COG1024	Enoyl-CoA hydratase
A4R43_07875	COG0028	Belongs to the TPP enzyme family
A4R43_07890	COG1024	Enoyl-CoA hydratase
A4R43_07895	COG1024	Enoyl-CoA hydratase
A4R43_07905	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_07950	COG2226	methyltransferase
A4R43_07965	COG3693	PFAM glycoside hydrolase, family 10
A4R43_08005	COG0659	secondary active sulfate transmembrane transporter activity
A4R43_08030	COG2197	response regulator
A4R43_08040	COG3903	Transcriptional regulator
A4R43_08040	COG3629	intracellular signal transduction
A4R43_08065	COG0583	DNA-binding transcription factor activity
A4R43_08080	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_08085	COG1309	transcriptional regulator
A4R43_08090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R43_08100	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_08110	COG0477	Major facilitator Superfamily
A4R43_08120	COG1733	regulation of RNA biosynthetic process
A4R43_08170	COG2318	DinB family
A4R43_08200	COG1136	(ABC) transporter
A4R43_08205	COG0577	efflux transmembrane transporter activity
A4R43_08205	COG1136	(ABC) transporter
A4R43_08220	COG0436	Aminotransferase
A4R43_08230	COG0596	Alpha beta hydrolase
A4R43_08255	COG0477	Major facilitator Superfamily
A4R43_08295	COG2124	cytochrome p450
A4R43_08310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R43_08340	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_08360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_08370	COG0463	Glycosyl transferase, family 2
A4R43_08390	COG1435	thymidine kinase activity
A4R43_08415	COG0640	Transcriptional regulator
A4R43_08445	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_08470	COG3795	YCII-related domain
A4R43_08475	COG4941	Belongs to the sigma-70 factor family
A4R43_08495	COG0702	epimerase
A4R43_08520	COG3795	YCII-related domain
A4R43_08525	COG4941	Belongs to the sigma-70 factor family
A4R43_08535	COG1733	regulation of RNA biosynthetic process
A4R43_08550	COG0640	Transcriptional regulator
A4R43_08560	COG1131	(ABC) transporter
A4R43_08565	COG1725	Transcriptional regulator
A4R43_08585	COG4221	oxidoreductase activity
A4R43_08595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4R43_08630	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
A4R43_08635	COG1846	Transcriptional regulator
A4R43_08645	COG1024	Enoyl-CoA hydratase
A4R43_08675	COG4974	Belongs to the 'phage' integrase family
A4R43_08690	COG4941	Belongs to the sigma-70 factor family
A4R43_08695	COG3795	YCII-related domain
A4R43_08760	COG4941	Belongs to the sigma-70 factor family
A4R43_08770	COG1522	sequence-specific DNA binding
A4R43_08780	COG0590	tRNA wobble adenosine to inosine editing
A4R43_08795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4R43_08805	COG0596	Alpha beta hydrolase
A4R43_08830	COG0596	Alpha beta hydrolase
A4R43_08840	COG0667	Aldo Keto reductase
A4R43_08845	COG4941	Belongs to the sigma-70 factor family
A4R43_08855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R43_08870	COG0431	NADPH-dependent FMN reductase
A4R43_08875	COG0477	Major facilitator Superfamily
A4R43_08950	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4R43_08980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R43_08985	COG0601	transmembrane transport
A4R43_08990	COG4166	transmembrane transport
A4R43_09000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_09005	COG3537	Alpha-1,2-mannosidase
A4R43_09020	COG0039	L-malate dehydrogenase activity
A4R43_09025	COG3104	oligopeptide transport
A4R43_09030	COG0339	signal peptide processing
A4R43_09040	COG1968	undecaprenyl-diphosphatase activity
A4R43_09045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_09050	COG0667	Aldo Keto reductase
A4R43_09065	COG0506	proline dehydrogenase activity
A4R43_09070	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_09085	COG0673	inositol 2-dehydrogenase activity
A4R43_09090	COG1470	cell adhesion involved in biofilm formation
A4R43_09090	COG0366	Alpha amylase catalytic
A4R43_09095	COG1349	DNA-binding transcription factor activity
A4R43_09110	COG0395	ABC-type sugar transport system, permease component
A4R43_09115	COG3833	ABC-type maltose transport systems, permease component
A4R43_09125	COG1349	DNA-binding transcription factor activity
A4R43_09135	COG1105	Belongs to the carbohydrate kinase PfkB family
A4R43_09140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_09145	COG1733	regulation of RNA biosynthetic process
A4R43_09155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_09160	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_09195	COG3795	YCII-related domain
A4R43_09200	COG4941	Belongs to the sigma-70 factor family
A4R43_09205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_09240	COG1201	RNA secondary structure unwinding
A4R43_09265	COG0515	serine threonine protein kinase
A4R43_09265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R43_09300	COG1733	regulation of RNA biosynthetic process
A4R43_09315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R43_09320	COG2124	cytochrome p450
A4R43_09335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4R43_09375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_09390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_09415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R43_09440	COG2211	Major facilitator Superfamily
A4R43_09450	COG2271	Major facilitator Superfamily
A4R43_09480	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_09495	COG1295	ribonuclease BN
A4R43_09505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_09510	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A4R43_09525	COG4608	Belongs to the ABC transporter superfamily
A4R43_09530	COG0444	Belongs to the ABC transporter superfamily
A4R43_09555	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_09565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R43_09570	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_09590	COG0596	Alpha beta hydrolase
A4R43_09615	COG1760	l-serine dehydratase
A4R43_09650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4R43_09655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_09670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_09675	COG2146	nitrite reductase [NAD(P)H] activity
A4R43_09680	COG1414	Transcriptional regulator
A4R43_09685	COG0477	Major facilitator Superfamily
A4R43_09695	COG0789	Transcriptional regulator
A4R43_09710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_09720	COG2226	methyltransferase
A4R43_09725	COG0604	alcohol dehydrogenase
A4R43_09750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_09770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4R43_09800	COG2814	Major facilitator Superfamily
A4R43_09810	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_09815	COG2197	response regulator
A4R43_09820	COG4585	Histidine kinase
A4R43_09830	COG2378	regulation of single-species biofilm formation
A4R43_09835	COG0596	Alpha beta hydrolase
A4R43_09860	COG3903	Transcriptional regulator
A4R43_09860	COG3629	intracellular signal transduction
A4R43_09865	COG1309	transcriptional regulator
A4R43_09875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R43_09880	COG0477	Major facilitator Superfamily
A4R43_09890	COG1120	ATPase activity
A4R43_09895	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_09900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_09905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R43_09910	COG2375	cellular response to nickel ion
A4R43_09915	COG1535	isochorismatase
A4R43_09915	COG3433	isochorismatase activity
A4R43_09920	COG3433	isochorismatase activity
A4R43_09920	COG1535	isochorismatase
A4R43_09925	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4R43_09930	COG1169	isochorismate synthase
A4R43_09935	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_09955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_09985	COG0667	Aldo Keto reductase
A4R43_09995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_10000	COG0346	lactoylglutathione lyase activity
A4R43_10015	COG0277	FAD linked oxidase domain protein
A4R43_10030	COG0477	Major facilitator Superfamily
A4R43_10060	COG2226	methyltransferase
A4R43_10065	COG4977	sequence-specific DNA binding
A4R43_10105	COG0583	DNA-binding transcription factor activity
A4R43_10110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_10150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_10180	COG0454	-acetyltransferase
A4R43_10180	COG0456	acetyltransferase
A4R43_10185	COG1136	(ABC) transporter
A4R43_10215	COG0745	RESPONSE REGULATOR receiver
A4R43_10230	COG3395	kinase activity
A4R43_10235	COG0235	Class ii aldolase
A4R43_10240	COG1349	DNA-binding transcription factor activity
A4R43_10315	COG1414	Transcriptional regulator
A4R43_10325	COG0477	Major facilitator Superfamily
A4R43_10330	COG1846	Transcriptional regulator
A4R43_10335	COG1764	response to oxidative stress
A4R43_10345	COG1280	lysine exporter protein (LysE YggA)
A4R43_10350	COG0726	polysaccharide deacetylase
A4R43_10355	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_10365	COG3386	PFAM SMP-30 Gluconolaconase
A4R43_10375	COG1414	Transcriptional regulator
A4R43_10380	COG2017	converts alpha-aldose to the beta-anomer
A4R43_10385	COG3940	Belongs to the glycosyl hydrolase 43 family
A4R43_10400	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_10405	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_10415	COG1879	ABC-type sugar transport system periplasmic component
A4R43_10420	COG1609	Transcriptional regulator
A4R43_10465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4R43_10475	COG3226	Transcriptional regulator
A4R43_10480	COG0738	Major facilitator superfamily
A4R43_10510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_10515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4R43_10530	COG2315	Protein conserved in bacteria
A4R43_10550	COG2755	lipolytic protein G-D-S-L family
A4R43_10550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4R43_10565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R43_10575	COG0789	Transcriptional regulator
A4R43_10625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_10635	COG0477	Major facilitator Superfamily
A4R43_10690	COG4552	Acetyltransferase involved in intracellular survival and related
A4R43_10710	COG4581	dead DEAH box helicase
A4R43_10730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R43_10740	COG2378	regulation of single-species biofilm formation
A4R43_10750	COG4447	cellulose binding
A4R43_10760	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4R43_10770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4R43_10775	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4R43_10815	COG1222	aaa ATPase
A4R43_10835	COG0517	IMP dehydrogenase activity
A4R43_10835	COG1994	Peptidase M50
A4R43_10855	COG0679	Auxin Efflux Carrier
A4R43_10860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4R43_10865	COG0140	phosphoribosyl-ATP diphosphatase activity
A4R43_10875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_10880	COG0646	methionine synthase
A4R43_10880	COG1410	methionine synthase
A4R43_10895	COG0477	Major facilitator Superfamily
A4R43_10900	COG2226	methyltransferase
A4R43_10925	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_10950	COG0488	(ABC) transporter
A4R43_10955	COG0488	(ABC) transporter
A4R43_10960	COG0215	cysteine-tRNA ligase activity
A4R43_10965	COG0789	Transcriptional regulator
A4R43_10995	COG4867	von Willebrand factor, type A
A4R43_11010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4R43_11020	COG1309	transcriptional regulator
A4R43_11040	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4R43_11050	COG0745	RESPONSE REGULATOR receiver
A4R43_11055	COG2205	protein histidine kinase activity
A4R43_11065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_11075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4R43_11080	COG2304	oxidoreductase activity
A4R43_11090	COG0714	Associated with various cellular activities
A4R43_11105	COG3883	PFAM NLP P60 protein
A4R43_11105	COG0791	NLP P60 protein
A4R43_11120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R43_11125	COG1285	pathogenesis
A4R43_11135	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A4R43_11140	COG0121	glutamine amidotransferase
A4R43_11145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4R43_11155	COG0583	DNA-binding transcription factor activity
A4R43_11160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4R43_11185	COG1309	transcriptional regulator
A4R43_11255	COG1716	ATPase activity
A4R43_11260	COG0509	glycine decarboxylation via glycine cleavage system
A4R43_11280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_11290	COG2267	carboxylic ester hydrolase activity
A4R43_11295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4R43_11295	COG1648	precorrin-2 dehydrogenase activity
A4R43_11325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4R43_11335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4R43_11340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4R43_11375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_11410	COG1132	(ABC) transporter
A4R43_11415	COG1309	transcriptional regulator
A4R43_11420	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_11425	COG1477	protein flavinylation
A4R43_11440	COG0745	RESPONSE REGULATOR receiver
A4R43_11445	COG2205	protein histidine kinase activity
A4R43_11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_11465	COG3842	ATPase activity
A4R43_11475	COG1486	melibiose metabolic process
A4R43_11480	COG0395	ABC-type sugar transport system, permease component
A4R43_11485	COG1175	transmembrane transport
A4R43_11505	COG0488	(ABC) transporter
A4R43_11510	COG0640	Transcriptional regulator
A4R43_11530	COG3706	GGDEF domain
A4R43_11555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R43_11560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R43_11595	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A4R43_11620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4R43_11640	COG4585	Histidine kinase
A4R43_11645	COG2197	response regulator
A4R43_11650	COG0439	Biotin carboxylase
A4R43_11655	COG5650	phosphatidylinositol metabolic process
A4R43_11670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4R43_11690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_11695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4R43_11705	COG0515	serine threonine protein kinase
A4R43_11725	COG1595	DNA-templated transcription, initiation
A4R43_11730	COG0477	Major facilitator Superfamily
A4R43_11735	COG0583	DNA-binding transcription factor activity
A4R43_11745	COG0154	amidase activity
A4R43_11755	COG1252	NADH dehydrogenase
A4R43_11810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_11825	COG1960	acyl-CoA dehydrogenase activity
A4R43_11840	COG1357	PFAM Pentapeptide repeats (8 copies)
A4R43_11895	COG0410	ABC transporter
A4R43_11915	COG1309	transcriptional regulator
A4R43_11925	COG3629	intracellular signal transduction
A4R43_11925	COG3903	Transcriptional regulator
A4R43_11930	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4R43_11975	COG1846	Transcriptional regulator
A4R43_11980	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_11985	COG1940	carbohydrate kinase activity
A4R43_11985	COG1846	Transcriptional regulator
A4R43_11990	COG0395	ABC-type sugar transport system, permease component
A4R43_11995	COG1175	transmembrane transport
A4R43_12010	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_12030	COG2267	carboxylic ester hydrolase activity
A4R43_12045	COG0583	DNA-binding transcription factor activity
A4R43_12050	COG2851	Citrate transporter
A4R43_12070	COG1653	transport
A4R43_12085	COG0515	serine threonine protein kinase
A4R43_12120	COG3345	alpha-galactosidase
A4R43_12140	COG2197	response regulator
A4R43_12265	COG1674	ftsk spoiiie
A4R43_12280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4R43_12300	COG0515	serine threonine protein kinase
A4R43_12355	COG3629	intracellular signal transduction
A4R43_12355	COG3903	Transcriptional regulator
A4R43_12460	COG1278	Cold shock
A4R43_12470	COG0697	spore germination
A4R43_12485	COG2226	methyltransferase
A4R43_12500	COG0154	amidase activity
A4R43_12520	COG2234	aminopeptidase activity
A4R43_12545	COG1309	transcriptional regulator
A4R43_12575	COG1819	glycosyl
A4R43_12580	COG1505	serine-type exopeptidase activity
A4R43_12590	COG1819	glycosyl
A4R43_12595	COG2124	cytochrome p450
A4R43_12600	COG0515	serine threonine protein kinase
A4R43_12615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4R43_12620	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_12625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R43_12625	COG3321	synthase
A4R43_12645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4R43_12655	COG0028	Belongs to the TPP enzyme family
A4R43_12665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_12695	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_12705	COG1960	acyl-CoA dehydrogenase activity
A4R43_12715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R43_12725	COG1119	ATPase activity
A4R43_12730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_12740	COG0477	Major facilitator Superfamily
A4R43_12750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_12770	COG0484	heat shock protein binding
A4R43_12775	COG0484	heat shock protein binding
A4R43_12825	COG1595	DNA-templated transcription, initiation
A4R43_12905	COG1120	ATPase activity
A4R43_12910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_12915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_12920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R43_12940	COG0477	Major facilitator Superfamily
A4R43_12965	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_12970	COG1129	ABC transporter
A4R43_13025	COG2072	flavoprotein involved in K transport
A4R43_13045	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_13080	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_13100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_13110	COG0477	Major facilitator Superfamily
A4R43_13115	COG1846	Transcriptional regulator
A4R43_13125	COG3226	Transcriptional regulator
A4R43_13140	COG1959	2 iron, 2 sulfur cluster binding
A4R43_13145	COG2815	serine threonine protein kinase
A4R43_13145	COG0515	serine threonine protein kinase
A4R43_13160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_13230	COG1929	Belongs to the glycerate kinase type-1 family
A4R43_13240	COG1408	metallophosphoesterase
A4R43_13245	COG1063	alcohol dehydrogenase
A4R43_13250	COG0129	dihydroxy-acid dehydratase activity
A4R43_13285	COG0454	-acetyltransferase
A4R43_13310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4R43_13315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_13325	COG1609	Transcriptional regulator
A4R43_13335	COG1733	regulation of RNA biosynthetic process
A4R43_13340	COG0222	ribosome binding
A4R43_13365	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_13370	COG0477	Major facilitator Superfamily
A4R43_13425	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_13440	COG1228	amidohydrolase
A4R43_13460	COG4172	Belongs to the ABC transporter superfamily
A4R43_13465	COG0747	negative chemotaxis
A4R43_13470	COG0601	transmembrane transport
A4R43_13495	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_13505	COG1063	alcohol dehydrogenase
A4R43_13510	COG0667	Aldo Keto reductase
A4R43_13525	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_13530	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_13535	COG1802	Transcriptional regulator
A4R43_13540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_13585	COG0596	Alpha beta hydrolase
A4R43_13595	COG5650	phosphatidylinositol metabolic process
A4R43_13600	COG0174	glutamine synthetase
A4R43_13620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4R43_13625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4R43_13640	COG2326	polyphosphate kinase activity
A4R43_13645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R43_13660	COG0488	(ABC) transporter
A4R43_13680	COG1595	DNA-templated transcription, initiation
A4R43_13690	COG1302	Protein conserved in bacteria
A4R43_13730	COG1793	dna ligase
A4R43_13755	COG0398	Pfam SNARE associated Golgi protein
A4R43_13770	COG0174	glutamine synthetase
A4R43_13780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4R43_13800	COG3220	belongs to the UPF0276 family
A4R43_13810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_13830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4R43_13840	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A4R43_13845	COG3766	membrane
A4R43_13865	COG2197	response regulator
A4R43_13890	COG0183	Belongs to the thiolase family
A4R43_13895	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_13895	COG1024	Enoyl-CoA hydratase
A4R43_13915	COG2205	protein histidine kinase activity
A4R43_13920	COG0745	RESPONSE REGULATOR receiver
A4R43_13945	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_13975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4R43_13985	COG2755	lipolytic protein G-D-S-L family
A4R43_13985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4R43_14005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4R43_14010	COG0531	amino acid
A4R43_14015	COG0569	domain protein
A4R43_14055	COG0756	dUTP diphosphatase activity
A4R43_14075	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_14095	COG1733	regulation of RNA biosynthetic process
A4R43_14100	COG0488	(ABC) transporter
A4R43_14105	COG1940	carbohydrate kinase activity
A4R43_14110	COG1309	transcriptional regulator
A4R43_14115	COG2124	cytochrome p450
A4R43_14135	COG1160	GTP binding
A4R43_14155	COG0475	glutathione-regulated potassium exporter activity
A4R43_14165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4R43_14170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4R43_14205	COG0504	CTP synthase activity
A4R43_14210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4R43_14230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4R43_14245	COG0647	UMP catabolic process
A4R43_14270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4R43_14275	COG2094	Belongs to the DNA glycosylase MPG family
A4R43_14300	COG0165	Argininosuccinate lyase
A4R43_14305	COG1438	arginine binding
A4R43_14315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R43_14320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4R43_14325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4R43_14330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4R43_14345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4R43_14345	COG0072	phenylalanine-tRNA ligase activity
A4R43_14350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4R43_14355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_14360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4R43_14365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4R43_14385	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A4R43_14410	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A4R43_14415	COG2610	gluconate transmembrane transporter activity
A4R43_14420	COG2706	6-phosphogluconolactonase activity
A4R43_14425	COG2801	Transposase and inactivated derivatives
A4R43_14425	COG3415	Transposase
A4R43_14445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4R43_14450	COG1316	TRANSCRIPTIONal
A4R43_14465	COG3290	protein histidine kinase activity
A4R43_14470	COG1301	dicarboxylic acid transport
A4R43_14490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_14520	COG1793	dna ligase
A4R43_14520	COG3285	dna ligase
A4R43_14540	COG0640	Transcriptional regulator
A4R43_14550	COG1126	abc transporter atp-binding protein
A4R43_14555	COG0765	amino acid transport
A4R43_14560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_14575	COG0390	transport system, permease component
A4R43_14585	COG0702	epimerase
A4R43_14590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_14610	COG0667	Aldo Keto reductase
A4R43_14615	COG1070	Carbohydrate kinase
A4R43_14625	COG1609	Transcriptional regulator
A4R43_14630	COG1879	ABC-type sugar transport system periplasmic component
A4R43_14635	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_14640	COG1129	ABC transporter
A4R43_14660	COG1396	sequence-specific DNA binding
A4R43_14670	COG4946	Tricorn protease homolog
A4R43_14670	COG1506	peptidase
A4R43_14670	COG0823	Involved in the tonB-independent uptake of proteins
A4R43_14675	COG0861	Integral membrane protein TerC family
A4R43_14680	COG1131	(ABC) transporter
A4R43_14710	COG1515	deoxyribonuclease V activity
A4R43_14715	COG1131	(ABC) transporter
A4R43_14730	COG4585	Histidine kinase
A4R43_14735	COG2197	response regulator
A4R43_14740	COG0237	dephospho-CoA kinase activity
A4R43_14740	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4R43_14755	COG3321	synthase
A4R43_14755	COG0604	alcohol dehydrogenase
A4R43_14755	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_14760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R43_14760	COG3321	synthase
A4R43_14765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_14790	COG0539	negative regulation of cytoplasmic translation
A4R43_14795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4R43_14815	COG1511	domain protein
A4R43_14850	COG2207	Transcriptional regulator
A4R43_14850	COG1917	Cupin 2, conserved barrel domain protein
A4R43_14880	COG0411	ABC transporter
A4R43_15000	COG3103	Sh3 type 3 domain protein
A4R43_15000	COG0791	NLP P60 protein
A4R43_15000	COG1388	LysM domain
A4R43_15025	COG4585	Histidine kinase
A4R43_15030	COG2197	response regulator
A4R43_15040	COG1136	(ABC) transporter
A4R43_15045	COG0494	nUDIX hydrolase
A4R43_15055	COG3629	intracellular signal transduction
A4R43_15055	COG3903	Transcriptional regulator
A4R43_15075	COG3209	COG3209 Rhs family protein
A4R43_15155	COG4585	Histidine kinase
A4R43_15160	COG2197	response regulator
A4R43_15175	COG0697	spore germination
A4R43_15190	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_15195	COG0784	Response regulator, receiver
A4R43_15200	COG4251	negative regulation of phosphorylation
A4R43_15215	COG1302	Protein conserved in bacteria
A4R43_15275	COG0583	DNA-binding transcription factor activity
A4R43_15285	COG0596	Alpha beta hydrolase
A4R43_15305	COG1063	alcohol dehydrogenase
A4R43_15330	COG1309	transcriptional regulator
A4R43_15360	COG1309	transcriptional regulator
A4R43_15375	COG2409	Drug exporters of the RND superfamily
A4R43_15380	COG2197	response regulator
A4R43_15390	COG1131	(ABC) transporter
A4R43_15425	COG0702	epimerase
A4R43_15445	COG1522	sequence-specific DNA binding
A4R43_15450	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4R43_15475	COG1309	transcriptional regulator
A4R43_15510	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4R43_15520	COG0714	Associated with various cellular activities
A4R43_15540	COG1573	uracil-dna glycosylase
A4R43_15580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A4R43_15585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4R43_15595	COG0028	Belongs to the TPP enzyme family
A4R43_15635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4R43_15645	COG3345	alpha-galactosidase
A4R43_15665	COG5492	domain, Protein
A4R43_15680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_15685	COG1414	Transcriptional regulator
A4R43_15690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R43_15740	COG2197	response regulator
A4R43_15760	COG4214	carbohydrate transport
A4R43_15770	COG4213	ABC transporter substrate-binding protein
A4R43_15790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R43_15810	COG2313	pseudouridylate synthase activity
A4R43_15825	COG1473	amidohydrolase
A4R43_15835	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_15840	COG1490	D-aminoacyl-tRNA deacylase activity
A4R43_15865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_15870	COG2188	Transcriptional regulator
A4R43_15880	COG2070	2-Nitropropane dioxygenase
A4R43_15890	COG1024	Enoyl-CoA hydratase
A4R43_15895	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4R43_15920	COG2226	methyltransferase
A4R43_15925	COG2124	cytochrome p450
A4R43_15930	COG0183	Belongs to the thiolase family
A4R43_15940	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_15945	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_15950	COG1024	Enoyl-CoA hydratase
A4R43_15970	COG0596	Alpha beta hydrolase
A4R43_15975	COG0110	maltose O-acetyltransferase activity
A4R43_15980	COG0183	Belongs to the thiolase family
A4R43_15985	COG1309	transcriptional regulator
A4R43_15990	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_15995	COG1960	acyl-CoA dehydrogenase activity
A4R43_16000	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_16005	COG1024	Enoyl-CoA hydratase
A4R43_16010	COG1960	acyl-CoA dehydrogenase activity
A4R43_16015	COG1960	acyl-CoA dehydrogenase activity
A4R43_16030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4R43_16035	COG0346	lactoylglutathione lyase activity
A4R43_16040	COG2267	carboxylic ester hydrolase activity
A4R43_16045	COG1960	acyl-CoA dehydrogenase activity
A4R43_16055	COG1053	succinate dehydrogenase
A4R43_16070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R43_16095	COG1960	acyl-CoA dehydrogenase activity
A4R43_16100	COG1960	acyl-CoA dehydrogenase activity
A4R43_16105	COG4977	sequence-specific DNA binding
A4R43_16110	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4R43_16120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4R43_16125	COG1960	acyl-CoA dehydrogenase activity
A4R43_16130	COG1309	transcriptional regulator
A4R43_16140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_16160	COG1703	isobutyryl-CoA mutase activity
A4R43_16160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R43_16160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R43_16175	COG2018	Roadblock/LC7 domain
A4R43_16190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_16195	COG0019	diaminopimelate decarboxylase activity
A4R43_16200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A4R43_16225	COG1566	PFAM secretion protein HlyD family protein
A4R43_16240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_16245	COG1960	acyl-CoA dehydrogenase activity
A4R43_16260	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_16270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_16270	COG1672	PFAM Archaeal ATPase
A4R43_16290	COG1946	Acyl-CoA thioesterase
A4R43_16325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R43_16350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_16360	COG1940	carbohydrate kinase activity
A4R43_16370	COG0003	Pfam Anion-transporting ATPase
A4R43_16455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_16465	COG3263	regulation of cellular component size
A4R43_16470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4R43_16495	COG1799	cell septum assembly
A4R43_16535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_16545	COG2318	DinB family
A4R43_16555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4R43_16560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4R43_16565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4R43_16575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4R43_16580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4R43_16635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_16640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_16650	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_16655	COG1960	acyl-CoA dehydrogenase activity
A4R43_16660	COG1960	acyl-CoA dehydrogenase activity
A4R43_16675	COG0123	including yeast histone deacetylase and acetoin utilization protein
A4R43_16690	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4R43_16695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4R43_16710	COG2936	dipeptidyl-peptidase activity
A4R43_16735	COG0596	Alpha beta hydrolase
A4R43_16745	COG2321	neutral zinc metallopeptidase
A4R43_16750	COG1505	serine-type exopeptidase activity
A4R43_16760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4R43_16770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4R43_16775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4R43_16780	COG4279	zinc finger
A4R43_16810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4R43_16830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4R43_16845	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4R43_16850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4R43_16860	COG1196	nuclear chromosome segregation
A4R43_16875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4R43_16880	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4R43_16885	COG3609	addiction module antidote protein, CC2985 family
A4R43_16895	COG2205	protein histidine kinase activity
A4R43_16900	COG0745	RESPONSE REGULATOR receiver
A4R43_16905	COG1126	abc transporter atp-binding protein
A4R43_16910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_16915	COG0765	amino acid transport
A4R43_16920	COG0765	amino acid transport
A4R43_16930	COG1053	succinate dehydrogenase
A4R43_16950	COG0800	Aldolase
A4R43_16960	COG2137	regulation of response to DNA damage stimulus
A4R43_16965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4R43_16975	COG0443	Heat shock 70 kDa protein
A4R43_16980	COG1201	RNA secondary structure unwinding
A4R43_16985	COG0242	peptide deformylase activity
A4R43_17025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_17030	COG0583	DNA-binding transcription factor activity
A4R43_17075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_17090	COG0515	serine threonine protein kinase
A4R43_17090	COG2815	serine threonine protein kinase
A4R43_17100	COG2268	Band 7 protein
A4R43_17120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A4R43_17135	COG0583	DNA-binding transcription factor activity
A4R43_17155	COG0070	glutamate synthase
A4R43_17155	COG0067	glutamate synthase
A4R43_17155	COG0069	glutamate synthase activity
A4R43_17160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4R43_17195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R43_17205	COG1124	(ABC) transporter
A4R43_17215	COG0601	transmembrane transport
A4R43_17225	COG0159	tryptophan synthase activity
A4R43_17230	COG0133	tryptophan synthase activity
A4R43_17235	COG0134	indole-3-glycerol-phosphate synthase activity
A4R43_17245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4R43_17250	COG1309	transcriptional regulator
A4R43_17255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4R43_17265	COG0107	imidazoleglycerol-phosphate synthase activity
A4R43_17290	COG3629	intracellular signal transduction
A4R43_17290	COG3903	Transcriptional regulator
A4R43_17300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4R43_17305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4R43_17320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_17325	COG1174	glycine betaine transport
A4R43_17330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_17340	COG2018	Roadblock/LC7 domain
A4R43_17350	COG1960	acyl-CoA dehydrogenase activity
A4R43_17365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_17375	COG0513	Belongs to the DEAD box helicase family
A4R43_17390	COG2843	Capsule synthesis protein
A4R43_17410	COG3958	Transketolase
A4R43_17415	COG3959	Transketolase, thiamine diphosphate binding domain
A4R43_17440	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A4R43_17445	COG0131	Imidazoleglycerol-phosphate dehydratase
A4R43_17450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4R43_17455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_17460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4R43_17470	COG2197	response regulator
A4R43_17490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4R43_17505	COG1674	ftsk spoiiie
A4R43_17530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R43_17530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R43_17545	COG1404	Belongs to the peptidase S8 family
A4R43_17550	COG0157	Belongs to the NadC ModD family
A4R43_17555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4R43_17575	COG0501	Belongs to the peptidase M48B family
A4R43_17590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4R43_17595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R43_17600	COG0659	secondary active sulfate transmembrane transporter activity
A4R43_17605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R43_17610	COG2124	cytochrome p450
A4R43_17630	COG1595	DNA-templated transcription, initiation
A4R43_17635	COG0438	transferase activity, transferring glycosyl groups
A4R43_17650	COG1876	peptidase activity
A4R43_17660	COG1136	(ABC) transporter
A4R43_17685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4R43_17695	COG2010	Cytochrome c
A4R43_17700	COG1845	cytochrome c oxidase, subunit III
A4R43_17710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4R43_17720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4R43_17735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_17745	COG1414	Transcriptional regulator
A4R43_17770	COG0667	Aldo Keto reductase
A4R43_17775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4R43_17785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R43_17820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R43_17825	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_17830	COG1309	transcriptional regulator
A4R43_17860	COG0321	lipoyl(octanoyl) transferase activity
A4R43_17885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4R43_17890	COG0586	Pfam SNARE associated Golgi protein
A4R43_17930	COG0587	DNA-directed DNA polymerase activity
A4R43_17935	COG2188	Transcriptional regulator
A4R43_17940	COG1113	amino acid transport
A4R43_17970	COG2267	carboxylic ester hydrolase activity
A4R43_17985	COG0596	Alpha beta hydrolase
A4R43_18030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4R43_18040	COG1620	l-lactate permease
A4R43_18045	COG3201	nicotinamide mononucleotide transporter
A4R43_18050	COG0668	transmembrane transport
A4R43_18070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4R43_18075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R43_18080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_18115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4R43_18120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4R43_18125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4R43_18155	COG2197	response regulator
A4R43_18160	COG0432	Pfam Uncharacterised protein family UPF0047
A4R43_18180	COG0442	prolyl-tRNA aminoacylation
A4R43_18200	COG3022	response to hydroperoxide
A4R43_18205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_18225	COG0513	Belongs to the DEAD box helicase family
A4R43_18260	COG2807	transmembrane transport
A4R43_18265	COG2186	Transcriptional regulator
A4R43_18270	COG1733	regulation of RNA biosynthetic process
A4R43_18290	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_18310	COG0454	-acetyltransferase
A4R43_18310	COG0456	acetyltransferase
A4R43_18325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4R43_18330	COG0750	zinc metalloprotease
A4R43_18335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4R43_18355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4R43_18360	COG1695	Transcriptional regulator
A4R43_18380	COG0233	cytoplasmic translational termination
A4R43_18385	COG0528	UMP kinase activity
A4R43_18390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4R43_18395	COG0052	Belongs to the universal ribosomal protein uS2 family
A4R43_18405	COG1191	sigma factor activity
A4R43_18420	COG0606	chelatase, subunit chli
A4R43_18425	COG0792	nuclease activity
A4R43_18435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4R43_18440	COG0681	Belongs to the peptidase S26 family
A4R43_18445	COG0335	large ribosomal subunit rRNA binding
A4R43_18450	COG0336	Belongs to the RNA methyltransferase TrmD family
A4R43_18465	COG0228	four-way junction DNA binding
A4R43_18490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4R43_18500	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4R43_18530	COG0667	Aldo Keto reductase
A4R43_18540	COG1832	CoA-binding protein
A4R43_18545	COG4266	Belongs to the allantoicase family
A4R43_18550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_18580	COG2233	PERMEase
A4R43_18585	COG1309	transcriptional regulator
A4R43_18600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_18620	COG3835	regulator
A4R43_18635	COG1414	Transcriptional regulator
A4R43_18640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R43_18650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A4R43_18655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_18675	COG1254	Belongs to the acylphosphatase family
A4R43_18695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4R43_18700	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4R43_18705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4R43_18715	COG0367	asparagine synthase
A4R43_18720	COG1940	carbohydrate kinase activity
A4R43_18755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4R43_18760	COG0571	ribonuclease III activity
A4R43_18765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4R43_18785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4R43_18790	COG0742	ribosomal rna small subunit methyltransferase
A4R43_18795	COG3973	AAA domain
A4R43_18800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_18845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_18895	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4R43_18900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_18910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_18920	COG3279	Response regulator of the LytR AlgR family
A4R43_18925	COG3275	phosphorelay sensor kinase activity
A4R43_18935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_18965	COG3507	Belongs to the glycosyl hydrolase 43 family
A4R43_18975	COG0673	inositol 2-dehydrogenase activity
A4R43_18980	COG1116	anion transmembrane transporter activity
A4R43_18980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_18990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_19015	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_19045	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_19060	COG1643	Atp-dependent helicase
A4R43_19075	COG0475	glutathione-regulated potassium exporter activity
A4R43_19085	COG2814	Major facilitator Superfamily
A4R43_19090	COG2910	NAD(P)H-binding
A4R43_19110	COG4221	oxidoreductase activity
A4R43_19115	COG1120	ATPase activity
A4R43_19125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4R43_19130	COG2186	Transcriptional regulator
A4R43_19135	COG1760	l-serine dehydratase
A4R43_19140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4R43_19145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4R43_19150	COG0509	glycine decarboxylation via glycine cleavage system
A4R43_19155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4R43_19160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4R43_19160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4R43_19170	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_19175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4R43_19185	COG0531	amino acid
A4R43_19190	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_19205	COG0673	inositol 2-dehydrogenase activity
A4R43_19210	COG1609	Transcriptional regulator
A4R43_19215	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_19220	COG1879	ABC-type sugar transport system periplasmic component
A4R43_19235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_19245	COG3718	enzyme involved in inositol metabolism
A4R43_19250	COG3962	Belongs to the TPP enzyme family
A4R43_19260	COG3795	YCII-related domain
A4R43_19300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4R43_19310	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_19315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R43_19320	COG1063	alcohol dehydrogenase
A4R43_19325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_19325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_19330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_19330	COG2213	PTS system mannitol-specific
A4R43_19340	COG1105	Belongs to the carbohydrate kinase PfkB family
A4R43_19345	COG1349	DNA-binding transcription factor activity
A4R43_19355	COG1414	Transcriptional regulator
A4R43_19360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_19365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4R43_19370	COG3485	protocatechuate 3,4-dioxygenase
A4R43_19375	COG3485	protocatechuate 3,4-dioxygenase
A4R43_19385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4R43_19390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4R43_19405	COG1929	Belongs to the glycerate kinase type-1 family
A4R43_19445	COG1984	allophanate hydrolase subunit 2
A4R43_19450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4R43_19455	COG4336	lyase activity
A4R43_19495	COG1461	Dihydroxyacetone kinase
A4R43_19500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4R43_19505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4R43_19535	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_19540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_19555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4R43_19580	COG3629	intracellular signal transduction
A4R43_19580	COG3903	Transcriptional regulator
A4R43_19590	COG0066	3-isopropylmalate dehydratase activity
A4R43_19595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4R43_19605	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_19620	COG0183	Belongs to the thiolase family
A4R43_19630	COG2205	protein histidine kinase activity
A4R43_19660	COG2409	Drug exporters of the RND superfamily
A4R43_19705	COG1131	(ABC) transporter
A4R43_19715	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A4R43_19740	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4R43_19745	COG1733	regulation of RNA biosynthetic process
A4R43_19750	COG2132	Multicopper oxidase
A4R43_19760	COG0583	DNA-binding transcription factor activity
A4R43_19770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_19775	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_19800	COG3959	Transketolase, thiamine diphosphate binding domain
A4R43_19805	COG3958	Transketolase
A4R43_19810	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_19820	COG1309	transcriptional regulator
A4R43_19845	COG2226	methyltransferase
A4R43_19850	COG1937	Protein conserved in bacteria
A4R43_19855	COG1309	transcriptional regulator
A4R43_19860	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_19880	COG0640	Transcriptional regulator
A4R43_19930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4R43_19940	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_19945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R43_19950	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_19955	COG1404	Belongs to the peptidase S8 family
A4R43_19990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4R43_19995	COG0440	acetolactate synthase activity
A4R43_20010	COG0129	dihydroxy-acid dehydratase activity
A4R43_20040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4R43_20050	COG0154	amidase activity
A4R43_20055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4R43_20065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_20070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4R43_20085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4R43_20085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_20095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_20100	COG3386	PFAM SMP-30 Gluconolaconase
A4R43_20115	COG0482	sulfurtransferase activity
A4R43_20125	COG0477	Major facilitator Superfamily
A4R43_20140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4R43_20150	COG1307	EDD domain protein, DegV family
A4R43_20160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4R43_20170	COG0386	Belongs to the glutathione peroxidase family
A4R43_20240	COG0110	maltose O-acetyltransferase activity
A4R43_20250	COG3103	Sh3 type 3 domain protein
A4R43_20250	COG0791	NLP P60 protein
A4R43_20250	COG1388	LysM domain
A4R43_20280	COG0346	lactoylglutathione lyase activity
A4R43_20290	COG0640	Transcriptional regulator
A4R43_20305	COG2814	Major facilitator Superfamily
A4R43_20310	COG0789	Transcriptional regulator
A4R43_20315	COG1846	Transcriptional regulator
A4R43_20320	COG0596	Alpha beta hydrolase
A4R43_20330	COG0640	Transcriptional regulator
A4R43_20335	COG2267	carboxylic ester hydrolase activity
A4R43_20360	COG0346	lactoylglutathione lyase activity
A4R43_20375	COG4195	phage-related replication protein
A4R43_20400	COG4585	Histidine kinase
A4R43_20405	COG2197	response regulator
A4R43_20425	COG1119	ATPase activity
A4R43_20440	COG0010	Belongs to the arginase family
A4R43_20460	COG0058	SHG alpha-glucan phosphorylase activity
A4R43_20485	COG1846	Transcriptional regulator
A4R43_20490	COG2409	Drug exporters of the RND superfamily
A4R43_20495	COG1609	Transcriptional regulator
A4R43_20520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4R43_20525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_20530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_20535	COG0300	oxidoreductase activity
A4R43_20540	COG1309	transcriptional regulator
A4R43_20555	COG0183	Belongs to the thiolase family
A4R43_20590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_20605	COG1418	mRNA catabolic process
A4R43_20615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4R43_20635	COG2226	methyltransferase
A4R43_20645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_20660	COG0433	COG0433 Predicted ATPase
A4R43_20665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4R43_20705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4R43_20720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_20730	COG3903	Transcriptional regulator
A4R43_20730	COG3629	intracellular signal transduction
A4R43_20745	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_20750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_20750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_20760	COG0297	glycogen (starch) synthase activity
A4R43_20780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_20790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_20790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_20795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_20815	COG3903	Transcriptional regulator
A4R43_20815	COG3629	intracellular signal transduction
A4R43_20820	COG2197	response regulator
A4R43_20830	COG0531	amino acid
A4R43_20875	COG1121	(ABC) transporter
A4R43_20895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R43_20910	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_20915	COG0387	Pfam Sodium calcium exchanger
A4R43_20950	COG2018	Roadblock/LC7 domain
A4R43_20955	COG2205	protein histidine kinase activity
A4R43_20980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R43_20985	COG1595	DNA-templated transcription, initiation
A4R43_21000	COG2018	Roadblock/LC7 domain
A4R43_21010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_21015	COG1116	anion transmembrane transporter activity
A4R43_21020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_21025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_21035	COG1309	transcriptional regulator
A4R43_21045	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_21055	COG3706	GGDEF domain
A4R43_21055	COG0745	RESPONSE REGULATOR receiver
A4R43_21060	COG3629	intracellular signal transduction
A4R43_21060	COG3903	Transcriptional regulator
A4R43_21075	COG1316	TRANSCRIPTIONal
A4R43_21110	COG0017	Asparaginyl-tRNA synthetase
A4R43_21125	COG1131	(ABC) transporter
A4R43_21135	COG0745	RESPONSE REGULATOR receiver
A4R43_21140	COG2205	protein histidine kinase activity
A4R43_21165	COG4977	sequence-specific DNA binding
A4R43_21185	COG0583	DNA-binding transcription factor activity
A4R43_21200	COG2610	gluconate transmembrane transporter activity
A4R43_21260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4R43_21285	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_21305	COG0477	Major facilitator Superfamily
A4R43_21310	COG0583	DNA-binding transcription factor activity
A4R43_21315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4R43_21320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4R43_21325	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_21330	COG1960	acyl-CoA dehydrogenase activity
A4R43_21340	COG1940	carbohydrate kinase activity
A4R43_21340	COG1846	Transcriptional regulator
A4R43_21395	COG0443	Heat shock 70 kDa protein
A4R43_21410	COG0745	RESPONSE REGULATOR receiver
A4R43_21415	COG2205	protein histidine kinase activity
A4R43_21420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4R43_21430	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A4R43_21435	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_21505	COG2409	Drug exporters of the RND superfamily
A4R43_21535	COG1960	acyl-CoA dehydrogenase activity
A4R43_21540	COG2897	thiosulfate sulfurtransferase activity
A4R43_21545	COG2814	Major facilitator Superfamily
A4R43_21565	COG0406	alpha-ribazole phosphatase activity
A4R43_21575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_21585	COG0583	DNA-binding transcription factor activity
A4R43_21595	COG1090	epimerase
A4R43_21630	COG0402	S-adenosylhomocysteine deaminase activity
A4R43_21690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4R43_21735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_21775	COG0791	NLP P60 protein
A4R43_21775	COG3883	PFAM NLP P60 protein
A4R43_21790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_21795	COG1643	Atp-dependent helicase
A4R43_21805	COG1131	(ABC) transporter
A4R43_21810	COG0671	phosphoesterase, PA-phosphatase related
A4R43_21830	COG2197	response regulator
A4R43_21835	COG4585	Histidine kinase
A4R43_21840	COG1819	glycosyl
A4R43_21860	COG1228	amidohydrolase
A4R43_21875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4R43_21880	COG2986	histidine ammonia-lyase
A4R43_21905	COG1937	Protein conserved in bacteria
A4R43_21945	COG4585	Histidine kinase
A4R43_21950	COG2197	response regulator
A4R43_21960	COG1846	Transcriptional regulator
A4R43_21980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4R43_21985	COG2177	Part of the ABC transporter FtsEX involved in
A4R43_21990	COG2884	Cell division ATP-binding protein ftsE
A4R43_21995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R43_22015	COG2378	regulation of single-species biofilm formation
A4R43_22025	COG1615	UPF0182 protein
A4R43_22035	COG3480	Lon protease (S16) C-terminal proteolytic domain
A4R43_22055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4R43_22115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4R43_22150	COG0174	glutamine synthetase
A4R43_22180	COG0653	protein targeting
A4R43_22190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_22190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4R43_22200	COG0519	Catalyzes the synthesis of GMP from XMP
A4R43_22215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_22235	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_22245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_22245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R43_22255	COG2376	Dihydroxyacetone kinase
A4R43_22275	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A4R43_22295	COG1024	Enoyl-CoA hydratase
A4R43_22305	COG1674	ftsk spoiiie
A4R43_22315	COG1280	lysine exporter protein (LysE YggA)
A4R43_22350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4R43_22355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4R43_22360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4R43_22365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4R43_22370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4R43_22375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4R43_22380	COG0356	it plays a direct role in the translocation of protons across the membrane
A4R43_22390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4R43_22400	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_22405	COG0789	Transcriptional regulator
A4R43_22410	COG0596	Alpha beta hydrolase
A4R43_22415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_22425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4R43_22430	COG0254	rRNA binding
A4R43_22445	COG0083	homoserine kinase activity
A4R43_22450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4R43_22460	COG0019	diaminopimelate decarboxylase activity
A4R43_22465	COG0018	arginyl-trna synthetase
A4R43_22485	COG0129	dihydroxy-acid dehydratase activity
A4R43_22500	COG4941	Belongs to the sigma-70 factor family
A4R43_22515	COG1280	lysine exporter protein (LysE YggA)
A4R43_22520	COG0667	Aldo Keto reductase
A4R43_22550	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_22555	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_22560	COG1129	ABC transporter
A4R43_22565	COG1879	ABC-type sugar transport system periplasmic component
A4R43_22580	COG4952	isomerase
A4R43_22595	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_22600	COG1129	ABC transporter
A4R43_22620	COG2267	carboxylic ester hydrolase activity
A4R43_22635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_22680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_22700	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_22735	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A4R43_22740	COG0535	radical SAM domain protein
A4R43_22750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4R43_22755	COG0667	Aldo Keto reductase
A4R43_22770	COG0154	amidase activity
A4R43_22795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4R43_22800	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_22810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4R43_22825	COG0028	Belongs to the TPP enzyme family
A4R43_22850	COG1024	Enoyl-CoA hydratase
A4R43_22850	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_22855	COG0183	Belongs to the thiolase family
A4R43_22870	COG1960	acyl-CoA dehydrogenase activity
A4R43_22880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4R43_22900	COG4221	oxidoreductase activity
A4R43_22915	COG1960	acyl-CoA dehydrogenase activity
A4R43_22925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_22950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4R43_22965	COG2508	Transcriptional regulator
A4R43_22965	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4R43_22985	COG0686	Belongs to the AlaDH PNT family
A4R43_22995	COG0477	Major facilitator Superfamily
A4R43_23010	COG1132	(ABC) transporter
A4R43_23015	COG3547	Transposase (IS116 IS110 IS902 family)
A4R43_23050	COG0567	Dehydrogenase, E1 component
A4R43_23050	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_23070	COG1174	glycine betaine transport
A4R43_23075	COG1174	glycine betaine transport
A4R43_23080	COG0517	IMP dehydrogenase activity
A4R43_23080	COG1125	glycine betaine transport
A4R43_23105	COG0406	alpha-ribazole phosphatase activity
A4R43_23120	COG1597	lipid kinase activity
A4R43_23135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A4R43_23145	COG1595	DNA-templated transcription, initiation
A4R43_23150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4R43_23160	COG2135	peptidase activity
A4R43_23165	COG1162	GTPase activity
A4R43_23175	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_23190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_23205	COG0653	protein targeting
A4R43_23210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4R43_23215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4R43_23220	COG5401	PFAM Sporulation and spore germination
A4R43_23225	COG5002	protein histidine kinase activity
A4R43_23230	COG0745	RESPONSE REGULATOR receiver
A4R43_23235	COG1414	Transcriptional regulator
A4R43_23245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4R43_23255	COG0531	amino acid
A4R43_23270	COG1482	cell wall glycoprotein biosynthetic process
A4R43_23280	COG2835	tetraacyldisaccharide 4'-kinase activity
A4R43_23310	COG1994	Peptidase M50
A4R43_23325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_23355	COG0747	negative chemotaxis
A4R43_23370	COG0180	Tryptophanyl-tRNA synthetase
A4R43_23385	COG0745	RESPONSE REGULATOR receiver
A4R43_23395	COG1131	(ABC) transporter
A4R43_23405	COG3842	ATPase activity
A4R43_23420	COG2154	pterin-4-alpha-carbinolamine dehydratase
A4R43_23450	COG0012	GTP binding
A4R43_23460	COG0419	ATPase involved in DNA repair
A4R43_23465	COG0420	3'-5' exonuclease activity
A4R43_23480	COG0667	Aldo Keto reductase
A4R43_23485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4R43_23495	COG1570	exodeoxyribonuclease VII activity
A4R43_23505	COG1722	exodeoxyribonuclease VII activity
A4R43_23520	COG0492	ferredoxin-NADP+ reductase activity
A4R43_23525	COG0114	fumarate hydratase activity
A4R43_23550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_23555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4R43_23560	COG1793	dna ligase
A4R43_23600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_23610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4R43_23630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_23655	COG1331	Highly conserved protein containing a thioredoxin domain
A4R43_23665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R43_23675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_23685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R43_23690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_23700	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A4R43_23705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_23745	COG0183	Belongs to the thiolase family
A4R43_23750	COG2391	methyltransferase activity
A4R43_23770	COG1902	pentaerythritol trinitrate reductase activity
A4R43_23775	COG0789	Transcriptional regulator
A4R43_23785	COG1802	Transcriptional regulator
A4R43_23790	COG1953	Uracil, thiamine, allantoin
A4R43_23810	COG1733	regulation of RNA biosynthetic process
A4R43_23820	COG4585	Histidine kinase
A4R43_23825	COG2197	response regulator
A4R43_23840	COG1252	NADH dehydrogenase
A4R43_23865	COG1404	Belongs to the peptidase S8 family
A4R43_23870	COG4608	Belongs to the ABC transporter superfamily
A4R43_23885	COG0601	transmembrane transport
A4R43_23890	COG0747	negative chemotaxis
A4R43_23920	COG0148	phosphopyruvate hydratase activity
A4R43_23945	COG0500	methyltransferase
A4R43_23975	COG2133	pyrroloquinoline quinone binding
A4R43_24010	COG3706	GGDEF domain
A4R43_24010	COG0745	RESPONSE REGULATOR receiver
A4R43_24015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4R43_24040	COG0193	aminoacyl-tRNA hydrolase activity
A4R43_24055	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_24060	COG0488	(ABC) transporter
A4R43_24065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4R43_24070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4R43_24075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_24080	COG3583	domain protein
A4R43_24085	COG0084	hydrolase, TatD family'
A4R43_24090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4R43_24175	COG2258	MOSC domain
A4R43_24185	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_24215	COG1309	transcriptional regulator
A4R43_24220	COG2910	NAD(P)H-binding
A4R43_24245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R43_24255	COG4942	peptidase
A4R43_24275	COG1609	Transcriptional regulator
A4R43_24285	COG2723	6-phospho-beta-galactosidase activity
A4R43_24300	COG3250	beta-galactosidase activity
A4R43_24305	COG3507	Belongs to the glycosyl hydrolase 43 family
A4R43_24335	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_24350	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_24365	COG1960	acyl-CoA dehydrogenase activity
A4R43_24370	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_24470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4R43_24480	COG0640	Transcriptional regulator
A4R43_24495	COG3261	NADH dehydrogenase
A4R43_24495	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A4R43_24500	COG0651	ATP synthesis coupled electron transport
A4R43_24510	COG0650	Formate hydrogenlyase subunit 4
A4R43_24520	COG3260	NADH ubiquinone oxidoreductase 20
A4R43_24570	COG3903	Transcriptional regulator
A4R43_24570	COG3629	intracellular signal transduction
A4R43_24590	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_24600	COG0720	synthase
A4R43_24625	COG0390	transport system, permease component
A4R43_24630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4R43_24640	COG0745	RESPONSE REGULATOR receiver
A4R43_24685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_24710	COG1051	belongs to the nudix hydrolase family
A4R43_24740	COG0285	dihydrofolate synthase activity
A4R43_24745	COG0009	L-threonylcarbamoyladenylate synthase
A4R43_24770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4R43_24775	COG3002	Belongs to the UPF0753 family
A4R43_24785	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_24790	COG0129	dihydroxy-acid dehydratase activity
A4R43_24800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R43_24825	COG3547	Transposase (IS116 IS110 IS902 family)
A4R43_24875	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A4R43_24950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4R43_24955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4R43_24970	COG1970	mechanosensitive ion channel activity
A4R43_24975	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4R43_24975	COG0315	cyclic pyranopterin monophosphate synthase activity
A4R43_24990	COG5002	protein histidine kinase activity
A4R43_24995	COG0745	RESPONSE REGULATOR receiver
A4R43_25035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_25045	COG1349	DNA-binding transcription factor activity
A4R43_25060	COG2860	membrane
A4R43_25065	COG2197	response regulator
A4R43_25130	COG0596	Alpha beta hydrolase
A4R43_25155	COG4585	Histidine kinase
A4R43_25155	COG2203	Gaf domain
A4R43_25160	COG0577	efflux transmembrane transporter activity
A4R43_25165	COG1136	(ABC) transporter
A4R43_25165	COG0577	efflux transmembrane transporter activity
A4R43_25180	COG0745	RESPONSE REGULATOR receiver
A4R43_25185	COG2205	protein histidine kinase activity
A4R43_25195	COG3177	Filamentation induced by cAMP protein fic
A4R43_25295	COG1335	isochorismatase
A4R43_25315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_25325	COG4221	oxidoreductase activity
A4R43_25330	COG2801	Transposase and inactivated derivatives
A4R43_25330	COG3415	Transposase
A4R43_25345	COG0745	RESPONSE REGULATOR receiver
A4R43_25350	COG2205	protein histidine kinase activity
A4R43_25355	COG2409	Drug exporters of the RND superfamily
A4R43_25370	COG1063	alcohol dehydrogenase
A4R43_25375	COG1113	amino acid transport
A4R43_25380	COG1321	iron dependent repressor
A4R43_25390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4R43_25395	COG1024	Enoyl-CoA hydratase
A4R43_25400	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_25420	COG1960	acyl-CoA dehydrogenase activity
A4R43_25425	COG1301	dicarboxylic acid transport
A4R43_25450	COG1169	isochorismate synthase
A4R43_25495	COG0277	FAD linked oxidase domain protein
A4R43_25520	COG4152	abc transporter atp-binding protein
A4R43_25525	COG1668	transmembrane transport
A4R43_25530	COG0415	Belongs to the DNA photolyase family
A4R43_25550	COG1960	acyl-CoA dehydrogenase activity
A4R43_25560	COG1228	amidohydrolase
A4R43_25565	COG2017	converts alpha-aldose to the beta-anomer
A4R43_25585	COG0259	pyridoxamine-phosphate oxidase activity
A4R43_25605	COG0829	nickel cation binding
A4R43_25610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4R43_25620	COG0804	urea catabolic process
A4R43_25625	COG0832	Belongs to the urease beta subunit family
A4R43_25630	COG0831	urea catabolic process
A4R43_25660	COG1131	(ABC) transporter
A4R43_25670	COG4585	Histidine kinase
A4R43_25675	COG2197	response regulator
A4R43_25690	COG5650	phosphatidylinositol metabolic process
A4R43_25705	COG1136	(ABC) transporter
A4R43_25705	COG0577	efflux transmembrane transporter activity
A4R43_25720	COG0745	RESPONSE REGULATOR receiver
A4R43_25725	COG2205	protein histidine kinase activity
A4R43_25745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_25760	COG5398	heme oxygenase
A4R43_25770	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4R43_25780	COG2814	Major facilitator Superfamily
A4R43_25790	COG2252	PERMEase
A4R43_25805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_25825	COG2814	Major facilitator Superfamily
A4R43_25835	COG1278	Cold shock
A4R43_25855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_25860	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_25865	COG0384	phenazine biosynthesis protein PhzF
A4R43_25870	COG3304	Inner membrane component domain
A4R43_25885	COG2175	clavaminate synthase activity
A4R43_25935	COG3415	Transposase
A4R43_25935	COG2801	Transposase and inactivated derivatives
A4R43_25960	COG2018	Roadblock/LC7 domain
A4R43_25975	COG2018	Roadblock/LC7 domain
A4R43_25990	COG0765	amino acid transport
A4R43_26005	COG3142	Participates in the control of copper homeostasis
A4R43_26025	COG1061	Type III restriction enzyme res subunit
A4R43_26045	COG3903	Transcriptional regulator
A4R43_26045	COG3629	intracellular signal transduction
A4R43_26050	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_26070	COG0459	protein refolding
A4R43_26080	COG1278	Cold shock
A4R43_26100	COG0688	phosphatidylethanolamine metabolic process
A4R43_26110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_26125	COG0242	peptide deformylase activity
A4R43_26140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4R43_26145	COG0351	phosphomethylpyrimidine kinase
A4R43_26170	COG2022	thiamine diphosphate biosynthetic process
A4R43_26180	COG2022	thiamine diphosphate biosynthetic process
A4R43_26180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_26185	COG0352	thiamine-phosphate diphosphorylase activity
A4R43_26200	COG0477	Major facilitator Superfamily
A4R43_26205	COG2188	Transcriptional regulator
A4R43_26210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_26215	COG2971	BadF BadG BcrA BcrD
A4R43_26225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4R43_26245	COG2885	chlorophyll binding
A4R43_26245	COG3047	cAMP biosynthetic process
A4R43_26265	COG3629	intracellular signal transduction
A4R43_26265	COG3903	Transcriptional regulator
A4R43_26270	COG5285	phytanoyl-CoA dioxygenase
A4R43_26275	COG1917	Cupin 2, conserved barrel domain protein
A4R43_26285	COG0456	acetyltransferase
A4R43_26295	COG4399	Belongs to the UPF0754 family
A4R43_26305	COG0400	carboxylic ester hydrolase activity
A4R43_26310	COG0346	lactoylglutathione lyase activity
A4R43_26345	COG0129	dihydroxy-acid dehydratase activity
A4R43_26365	COG0477	Major facilitator Superfamily
A4R43_26370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R43_26375	COG2151	metal-sulfur cluster biosynthetic enzyme
A4R43_26380	COG3396	Phenylacetate-CoA oxygenase
A4R43_26385	COG3460	Phenylacetate-CoA oxygenase
A4R43_26390	COG3396	Phenylacetate-CoA oxygenase
A4R43_26395	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_26395	COG2030	dehydratase
A4R43_26405	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_26420	COG1309	transcriptional regulator
A4R43_26440	COG1832	CoA-binding protein
A4R43_26470	COG2197	response regulator
A4R43_26490	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4R43_26490	COG1902	pentaerythritol trinitrate reductase activity
A4R43_26495	COG1695	Transcriptional regulator
A4R43_26500	COG0583	DNA-binding transcription factor activity
A4R43_26505	COG0384	phenazine biosynthesis protein PhzF
A4R43_26520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_26530	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A4R43_26565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4R43_26570	COG2847	Copper chaperone PCu(A)C
A4R43_26575	COG1329	Transcriptional regulator
A4R43_26585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4R43_26595	COG0215	cysteine-tRNA ligase activity
A4R43_26655	COG4399	Belongs to the UPF0754 family
A4R43_26670	COG1120	ATPase activity
A4R43_26680	COG1609	Transcriptional regulator
A4R43_26690	COG1194	a g-specific adenine glycosylase
A4R43_26700	COG0596	Alpha beta hydrolase
A4R43_26715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4R43_26740	COG0542	response to heat
A4R43_26765	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4R43_26770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4R43_26795	COG0789	Transcriptional regulator
A4R43_26815	COG0302	gtp cyclohydrolase
A4R43_26820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_26850	COG0037	tRNA processing
A4R43_26870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4R43_26895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4R43_26905	COG0471	metal ion transport
A4R43_26915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4R43_26935	COG3550	peptidyl-serine autophosphorylation
A4R43_26950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4R43_26965	COG1754	DNA topoisomerase type I activity
A4R43_26965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4R43_26990	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A4R43_26995	COG1111	helicase
A4R43_26995	COG1205	dead DEAH box helicase
A4R43_27045	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_27050	COG3876	Protein conserved in bacteria
A4R43_27055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_27060	COG1737	Transcriptional regulator
A4R43_27065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4R43_27075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A4R43_27085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_27125	COG3104	oligopeptide transport
A4R43_27130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R43_27140	COG0596	Alpha beta hydrolase
A4R43_27155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R43_27225	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4R43_27270	COG2226	methyltransferase
A4R43_27285	COG1764	response to oxidative stress
A4R43_27325	COG1690	Belongs to the RtcB family
A4R43_27365	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_27375	COG0583	DNA-binding transcription factor activity
A4R43_27385	COG0702	epimerase
A4R43_27390	COG4608	Belongs to the ABC transporter superfamily
A4R43_27395	COG0444	Belongs to the ABC transporter superfamily
A4R43_27410	COG0747	negative chemotaxis
A4R43_27420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4R43_27425	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4R43_27430	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R43_27435	COG1733	regulation of RNA biosynthetic process
A4R43_27440	COG3467	pyridoxamine 5'-phosphate
A4R43_27455	COG3540	Alkaline phosphatase
A4R43_27460	COG2205	protein histidine kinase activity
A4R43_27465	COG0745	RESPONSE REGULATOR receiver
A4R43_27475	COG2197	response regulator
A4R43_27515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4R43_27555	COG1739	Uncharacterized protein family UPF0029
A4R43_27580	COG0745	RESPONSE REGULATOR receiver
A4R43_27585	COG2205	protein histidine kinase activity
A4R43_27610	COG1674	ftsk spoiiie
A4R43_27660	COG0287	Prephenate dehydrogenase
A4R43_27685	COG1131	(ABC) transporter
A4R43_27690	COG3559	Exporter of polyketide antibiotics
A4R43_27700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_27700	COG2010	Cytochrome c
A4R43_27705	COG2080	2 iron, 2 sulfur cluster binding
A4R43_27720	COG2183	response to ionizing radiation
A4R43_27725	COG2197	response regulator
A4R43_27730	COG4585	Histidine kinase
A4R43_27770	COG0667	Aldo Keto reductase
A4R43_27845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_27865	COG0412	Dienelactone hydrolase
A4R43_27870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4R43_27890	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A4R43_27900	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4R43_27920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R43_27925	COG2197	response regulator
A4R43_27930	COG4585	Histidine kinase
A4R43_27970	COG1960	acyl-CoA dehydrogenase activity
A4R43_27980	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_27980	COG1672	PFAM Archaeal ATPase
A4R43_28080	COG1216	Glycosyl transferase, family 2
A4R43_28120	COG1216	Glycosyl transferase, family 2
A4R43_28130	COG0277	FAD linked oxidase domain protein
A4R43_28135	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_28160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4R43_28180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_28185	COG0561	phosphatase activity
A4R43_28230	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_28235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_28255	COG0673	inositol 2-dehydrogenase activity
A4R43_28300	COG0438	transferase activity, transferring glycosyl groups
A4R43_28310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_28340	COG0579	oxidoreductase
A4R43_28355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4R43_28360	COG0596	Alpha beta hydrolase
A4R43_28365	COG3766	membrane
A4R43_28370	COG0754	glutathionylspermidine amidase activity
A4R43_28420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4R43_28435	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R43_28440	COG1072	(Pantothenic acid kinase))
A4R43_28450	COG4715	Zinc finger, swim domain protein
A4R43_28510	COG4988	ABC transporter
A4R43_28515	COG1294	oxidase, subunit
A4R43_28520	COG1271	oxidase subunit
A4R43_28580	COG2235	arginine
A4R43_28585	COG1528	Iron-storage protein
A4R43_28595	COG1191	sigma factor activity
A4R43_28625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_28635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_28670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4R43_28690	COG3397	chitin binding
A4R43_28710	COG2234	aminopeptidase activity
A4R43_28715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4R43_28760	COG0438	transferase activity, transferring glycosyl groups
A4R43_28780	COG2197	response regulator
A4R43_28785	COG4585	Histidine kinase
A4R43_28795	COG0477	Major facilitator Superfamily
A4R43_28830	COG0697	spore germination
A4R43_28835	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4R43_28870	COG1174	glycine betaine transport
A4R43_28880	COG1174	glycine betaine transport
A4R43_28885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4R43_28935	COG2211	Major facilitator Superfamily
A4R43_28940	COG2723	6-phospho-beta-galactosidase activity
A4R43_28960	COG0702	epimerase
A4R43_28975	COG0515	serine threonine protein kinase
A4R43_28985	COG2301	Belongs to the HpcH HpaI aldolase family
A4R43_29000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_29010	COG0154	amidase activity
A4R43_29015	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_29020	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_29025	COG4608	Belongs to the ABC transporter superfamily
A4R43_29045	COG0747	negative chemotaxis
A4R43_29090	COG1716	ATPase activity
A4R43_29095	COG1716	ATPase activity
A4R43_29110	COG0768	penicillin binding
A4R43_29115	COG0515	serine threonine protein kinase
A4R43_29120	COG0515	serine threonine protein kinase
A4R43_29120	COG2815	serine threonine protein kinase
A4R43_29135	COG3764	Sortase (surface protein transpeptidase)
A4R43_29265	COG3629	intracellular signal transduction
A4R43_29265	COG3903	Transcriptional regulator
A4R43_29285	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_29330	COG3118	belongs to the thioredoxin family
A4R43_29360	COG0484	heat shock protein binding
A4R43_29435	COG0443	Heat shock 70 kDa protein
A4R43_29440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4R43_29445	COG0484	heat shock protein binding
A4R43_29455	COG0542	response to heat
A4R43_29460	COG0501	Belongs to the peptidase M48B family
A4R43_29465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_29495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R43_29515	COG0602	queuosine metabolic process
A4R43_29575	COG0438	transferase activity, transferring glycosyl groups
A4R43_29585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4R43_29600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4R43_29610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4R43_29630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4R43_29760	COG3328	transposase activity
A4R43_29770	COG1063	alcohol dehydrogenase
A4R43_29780	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_29790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_29790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_29795	COG1024	Enoyl-CoA hydratase
A4R43_29805	COG1960	acyl-CoA dehydrogenase activity
A4R43_29825	COG1309	transcriptional regulator
A4R43_29865	COG2409	Drug exporters of the RND superfamily
A4R43_29940	COG0477	Major facilitator Superfamily
A4R43_29980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_30010	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_30030	COG3344	reverse transcriptase
A4R43_30060	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_30070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4R43_30075	COG0492	ferredoxin-NADP+ reductase activity
A4R43_30080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_30090	COG4191	Histidine kinase
A4R43_30095	COG2197	response regulator
A4R43_30145	COG1127	ABC transporter
A4R43_30175	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_30210	COG1960	acyl-CoA dehydrogenase activity
A4R43_30235	COG3328	transposase activity
A4R43_30405	COG0187	DNA topoisomerase II activity
A4R43_30410	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A4R43_30415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4R43_30420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A4R43_30425	COG0592	DNA-directed DNA polymerase activity
A4R43_30435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4R43_30440	COG0706	membrane insertase activity
A4R43_30450	COG0357	Ribosomal RNA small subunit methyltransferase G
A4R43_30455	COG1192	Involved in chromosome partitioning
A4R43_30465	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_30480	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R43_30480	COG3409	Peptidoglycan-binding domain 1 protein
A4R43_30485	COG3118	belongs to the thioredoxin family
A4R43_30485	COG0492	ferredoxin-NADP+ reductase activity
A4R43_30500	COG1595	DNA-templated transcription, initiation
A4R43_30515	COG0765	amino acid transport
A4R43_30520	COG0765	amino acid transport
A4R43_30545	COG4585	Histidine kinase
A4R43_30600	COG1678	Uncharacterized ACR, COG1678
A4R43_30615	COG0495	leucyl-tRNA aminoacylation
A4R43_30640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_30650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R43_30665	COG2197	response regulator
A4R43_30690	COG3384	dioxygenase
A4R43_30755	COG0359	binds to the 23S rRNA
A4R43_30760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4R43_30770	COG0360	Binds together with S18 to 16S ribosomal RNA
A4R43_30805	COG1940	carbohydrate kinase activity
A4R43_30810	COG0673	inositol 2-dehydrogenase activity
A4R43_30815	COG1228	amidohydrolase
A4R43_30820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4R43_30830	COG1695	Transcriptional regulator
A4R43_30845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_30850	COG2814	Major facilitator Superfamily
A4R43_30865	COG0842	Transport permease protein
A4R43_30885	COG4221	oxidoreductase activity
A4R43_30895	COG4585	Histidine kinase
A4R43_30900	COG2197	response regulator
A4R43_30905	COG0402	S-adenosylhomocysteine deaminase activity
A4R43_30910	COG2197	response regulator
A4R43_30920	COG1136	(ABC) transporter
A4R43_30930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4R43_30950	COG2197	response regulator
A4R43_30955	COG4585	Histidine kinase
A4R43_30995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4R43_31000	COG4133	protoheme IX ABC transporter activity
A4R43_31055	COG0456	acetyltransferase
A4R43_31055	COG1846	Transcriptional regulator
A4R43_31065	COG0789	Transcriptional regulator
A4R43_31075	COG0584	glycerophosphoryl diester phosphodiesterase
A4R43_31085	COG0183	Belongs to the thiolase family
A4R43_31090	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_31095	COG2030	dehydratase
A4R43_31100	COG1309	transcriptional regulator
A4R43_31115	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4R43_31125	COG1132	(ABC) transporter
A4R43_31140	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_31145	COG0022	dehydrogenase e1 component
A4R43_31155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_31170	COG0765	amino acid transport
A4R43_31190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R43_31195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4R43_31205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4R43_31225	COG1960	acyl-CoA dehydrogenase activity
A4R43_31230	COG2197	response regulator
A4R43_31250	COG0737	Belongs to the 5'-nucleotidase family
A4R43_31265	COG1742	UPF0060 membrane protein
A4R43_31300	COG2340	Cysteine-rich secretory protein family
A4R43_31305	COG1024	Enoyl-CoA hydratase
A4R43_31310	COG1960	acyl-CoA dehydrogenase activity
A4R43_31315	COG1309	transcriptional regulator
A4R43_31335	COG1522	sequence-specific DNA binding
A4R43_31355	COG2181	nitrate reductase activity
A4R43_31355	COG0247	lactate metabolic process
A4R43_31395	COG0443	Heat shock 70 kDa protein
A4R43_31400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4R43_31405	COG0484	heat shock protein binding
A4R43_31410	COG0789	Transcriptional regulator
A4R43_31430	COG0542	response to heat
A4R43_31440	COG0300	oxidoreductase activity
A4R43_31460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_31465	COG0243	molybdopterin cofactor binding
A4R43_31480	COG1609	Transcriptional regulator
A4R43_31510	COG1072	(Pantothenic acid kinase))
A4R43_31515	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_31520	COG2188	Transcriptional regulator
A4R43_31525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_31535	COG0586	Pfam SNARE associated Golgi protein
A4R43_31540	COG2353	YceI-like domain
A4R43_31560	COG0477	Major facilitator Superfamily
A4R43_31575	COG0277	FAD linked oxidase domain protein
A4R43_31580	COG0586	Pfam SNARE associated Golgi protein
A4R43_31615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R43_31655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4R43_31665	COG0584	glycerophosphoryl diester phosphodiesterase
A4R43_31710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R43_31710	COG0515	serine threonine protein kinase
A4R43_31725	COG3953	SLT domain
A4R43_31725	COG5280	Phage tail tape measure protein TP901
A4R43_31735	COG0436	Aminotransferase
A4R43_31775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4R43_31785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_31790	COG0765	amino acid transport
A4R43_31795	COG1126	abc transporter atp-binding protein
A4R43_31805	COG0730	response to heat
A4R43_31845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4R43_31850	COG0047	phosphoribosylformylglycinamidine synthase activity
A4R43_31855	COG1132	(ABC) transporter
A4R43_31860	COG1132	(ABC) transporter
A4R43_31935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4R43_31940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R43_31950	COG4565	transcriptional regulatory protein
A4R43_31955	COG3290	protein histidine kinase activity
A4R43_31995	COG3845	ABC transporter
A4R43_32035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R43_32045	COG1984	allophanate hydrolase subunit 2
A4R43_32050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4R43_32055	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A4R43_32075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R43_32085	COG0745	RESPONSE REGULATOR receiver
A4R43_32090	COG0454	-acetyltransferase
A4R43_32090	COG0456	acetyltransferase
A4R43_32110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4R43_32130	COG2508	Transcriptional regulator
A4R43_32130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4R43_32135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_32155	COG1309	transcriptional regulator
A4R43_32180	COG2272	Belongs to the type-B carboxylesterase lipase family
A4R43_32205	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_32235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R43_32280	COG1316	TRANSCRIPTIONal
A4R43_32290	COG2199	diguanylate cyclase activity
A4R43_32290	COG2203	Gaf domain
A4R43_32300	COG0204	Acyl-transferase
A4R43_32300	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_32345	COG0443	Heat shock 70 kDa protein
A4R43_32385	COG0515	serine threonine protein kinase
A4R43_32390	COG1132	(ABC) transporter
A4R43_32395	COG1132	(ABC) transporter
A4R43_32430	COG4585	Histidine kinase
A4R43_32435	COG2197	response regulator
A4R43_32445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_32450	COG1414	Transcriptional regulator
A4R43_32455	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_32460	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_32470	COG0515	serine threonine protein kinase
A4R43_32475	COG1408	metallophosphoesterase
A4R43_32495	COG1595	DNA-templated transcription, initiation
A4R43_32510	COG1278	Cold shock
A4R43_32540	COG1027	Aspartate ammonia-lyase
A4R43_32610	COG2364	Membrane
A4R43_32615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_32635	COG2733	membrane
A4R43_32645	COG3795	YCII-related domain
A4R43_32650	COG4941	Belongs to the sigma-70 factor family
A4R43_32670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4R43_32675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_32705	COG2130	NADP-dependent
A4R43_32715	COG0788	formyltetrahydrofolate deformylase activity
A4R43_32735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4R43_32750	COG0438	transferase activity, transferring glycosyl groups
A4R43_32785	COG0667	Aldo Keto reductase
A4R43_32790	COG5002	protein histidine kinase activity
A4R43_32815	COG0506	proline dehydrogenase activity
A4R43_32825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4R43_32855	COG0560	Phosphoserine phosphatase
A4R43_32865	COG1595	DNA-templated transcription, initiation
A4R43_32870	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_32910	COG3629	intracellular signal transduction
A4R43_32910	COG3903	Transcriptional regulator
A4R43_32915	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4R43_32920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4R43_32925	COG0181	hydroxymethylbilane synthase activity
A4R43_32930	COG1648	precorrin-2 dehydrogenase activity
A4R43_32930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4R43_32955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4R43_32960	COG0406	alpha-ribazole phosphatase activity
A4R43_32980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R43_33000	COG1522	sequence-specific DNA binding
A4R43_33035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4R43_33040	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4R43_33055	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_33065	COG0438	transferase activity, transferring glycosyl groups
A4R43_33070	COG2226	methyltransferase
A4R43_33085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R43_33090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R43_33095	COG0649	NAD binding
A4R43_33110	COG1034	ATP synthesis coupled electron transport
A4R43_33115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4R43_33120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R43_33125	COG0839	Belongs to the complex I subunit 6 family
A4R43_33130	COG0713	ATP synthesis coupled electron transport
A4R43_33145	COG1007	ATP synthesis coupled electron transport
A4R43_33235	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4R43_33240	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4R43_33240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4R43_33250	COG1522	sequence-specific DNA binding
A4R43_33255	COG1834	amidinotransferase
A4R43_33260	COG1215	transferase activity, transferring glycosyl groups
A4R43_33335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_33350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_33355	COG0438	transferase activity, transferring glycosyl groups
A4R43_33370	COG0673	inositol 2-dehydrogenase activity
A4R43_33390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4R43_33395	COG0596	Alpha beta hydrolase
A4R43_33400	COG1309	transcriptional regulator
A4R43_33410	COG1666	GTP binding
A4R43_33450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4R43_33455	COG2197	response regulator
A4R43_33460	COG4585	Histidine kinase
A4R43_33470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4R43_33500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4R43_33510	COG2030	dehydratase
A4R43_33530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_33540	COG0436	Aminotransferase
A4R43_33560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4R43_33565	COG0081	regulation of translation
A4R43_33585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4R43_33590	COG0222	ribosome binding
A4R43_33605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_33655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4R43_33660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4R43_33680	COG4585	Histidine kinase
A4R43_33685	COG2197	response regulator
A4R43_33690	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A4R43_33740	COG1940	carbohydrate kinase activity
A4R43_33750	COG1129	ABC transporter
A4R43_33755	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_33765	COG0673	inositol 2-dehydrogenase activity
A4R43_33780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4R43_33790	COG0084	hydrolase, TatD family'
A4R43_33815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4R43_33820	COG0049	tRNA binding
A4R43_33825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4R43_33840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4R43_33845	COG0088	Forms part of the polypeptide exit tunnel
A4R43_33850	COG0089	rRNA binding
A4R43_33855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4R43_33860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4R43_33865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4R43_33870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4R43_33875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4R43_33880	COG0255	Belongs to the universal ribosomal protein uL29 family
A4R43_33885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4R43_33890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4R43_33895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4R43_33900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4R43_33910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4R43_33915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4R43_33920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4R43_33925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4R43_33930	COG1841	ribosomal large subunit assembly
A4R43_33935	COG0200	Binds to the 23S rRNA
A4R43_33945	COG1280	lysine exporter protein (LysE YggA)
A4R43_33955	COG0563	adenylate kinase activity
A4R43_33965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4R43_33970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4R43_33975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4R43_33985	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4R43_33990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4R43_33995	COG0202	RNA polymerase activity
A4R43_34000	COG0203	ribosomal protein L17
A4R43_34005	COG0101	tRNA pseudouridine synthase activity
A4R43_34040	COG1404	Belongs to the peptidase S8 family
A4R43_34050	COG1674	ftsk spoiiie
A4R43_34055	COG0443	Heat shock 70 kDa protein
A4R43_34095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4R43_34100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4R43_34105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4R43_34125	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_34155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_34175	COG0395	ABC-type sugar transport system, permease component
A4R43_34180	COG1063	alcohol dehydrogenase
A4R43_34185	COG1349	DNA-binding transcription factor activity
A4R43_34190	COG1063	alcohol dehydrogenase
A4R43_34195	COG1070	Carbohydrate kinase
A4R43_34200	COG3842	ATPase activity
A4R43_34205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4R43_34215	COG0802	atpase or kinase
A4R43_34220	COG3458	cephalosporin-C deacetylase activity
A4R43_34225	COG0154	amidase activity
A4R43_34230	COG0825	malonyl-CoA metabolic process
A4R43_34230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4R43_34235	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_34245	COG2186	Transcriptional regulator
A4R43_34250	COG3209	COG3209 Rhs family protein
A4R43_34270	COG0456	acetyltransferase
A4R43_34275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4R43_34285	COG3540	Alkaline phosphatase
A4R43_34290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4R43_34295	COG0459	protein refolding
A4R43_34300	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_34305	COG1309	transcriptional regulator
A4R43_34350	COG0516	GMP reductase activity
A4R43_34370	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_34375	COG0519	Catalyzes the synthesis of GMP from XMP
A4R43_34375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4R43_34405	COG0583	DNA-binding transcription factor activity
A4R43_34410	COG0515	serine threonine protein kinase
A4R43_34410	COG2815	serine threonine protein kinase
A4R43_34465	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R43_34490	COG0138	bifunctional purine biosynthesis protein purh
A4R43_34530	COG0587	DNA-directed DNA polymerase activity
A4R43_34550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4R43_34560	COG2814	Major facilitator Superfamily
A4R43_34565	COG0640	Transcriptional regulator
A4R43_34570	COG2814	Major facilitator Superfamily
A4R43_34610	COG0708	Exodeoxyribonuclease III
A4R43_34615	COG2801	Transposase and inactivated derivatives
A4R43_34615	COG3415	Transposase
A4R43_34635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4R43_34645	COG0180	Tryptophanyl-tRNA synthetase
A4R43_34665	COG1295	ribonuclease BN
A4R43_34670	COG2814	Major facilitator Superfamily
A4R43_34675	COG1686	Belongs to the peptidase S11 family
A4R43_34720	COG1609	Transcriptional regulator
A4R43_34730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R43_34745	COG2009	succinate dehydrogenase
A4R43_34785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4R43_34790	COG2271	Major facilitator Superfamily
A4R43_34835	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_34840	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_34845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4R43_34895	COG0667	Aldo Keto reductase
A4R43_34900	COG0667	Aldo Keto reductase
A4R43_34910	COG0477	Major facilitator Superfamily
A4R43_34940	COG0706	membrane insertase activity
A4R43_34945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4R43_34960	COG0515	serine threonine protein kinase
A4R43_34985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_34985	COG1473	amidohydrolase
A4R43_35010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4R43_35015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4R43_35020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4R43_35025	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_35035	COG2197	response regulator
A4R43_35040	COG3851	Histidine kinase
A4R43_35050	COG4770	biotin carboxylase activity
A4R43_35055	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A4R43_35060	COG0235	Class ii aldolase
A4R43_35065	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A4R43_35070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4R43_35080	COG0813	purine-nucleoside phosphorylase activity
A4R43_35115	COG1301	dicarboxylic acid transport
A4R43_35120	COG0424	maF-like protein
A4R43_35135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_35155	COG0596	Alpha beta hydrolase
A4R43_35175	COG1725	Transcriptional regulator
A4R43_35210	COG1388	LysM domain
A4R43_35210	COG0791	NLP P60 protein
A4R43_35210	COG3103	Sh3 type 3 domain protein
A4R43_35215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4R43_35215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4R43_35255	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_35260	COG0745	RESPONSE REGULATOR receiver
A4R43_35265	COG2205	protein histidine kinase activity
A4R43_35315	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_35320	COG1960	acyl-CoA dehydrogenase activity
A4R43_35335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_35345	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_35355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_35360	COG5479	isomerase activity
A4R43_35360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A4R43_35370	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_35395	COG2259	Doxx family
A4R43_35405	COG1316	TRANSCRIPTIONal
A4R43_35410	COG1316	TRANSCRIPTIONal
A4R43_35440	COG0438	transferase activity, transferring glycosyl groups
A4R43_35475	COG1725	Transcriptional regulator
A4R43_35495	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A4R43_35495	COG0778	Nitroreductase
A4R43_35555	COG1611	Belongs to the LOG family
A4R43_35570	COG0463	Glycosyl transferase, family 2
A4R43_35580	COG4988	ABC transporter
A4R43_35585	COG1294	oxidase, subunit
A4R43_35590	COG1271	oxidase subunit
A4R43_35615	COG0519	Catalyzes the synthesis of GMP from XMP
A4R43_35625	COG1024	Enoyl-CoA hydratase
A4R43_35635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4R43_35640	COG0583	DNA-binding transcription factor activity
A4R43_35645	COG2814	Major facilitator Superfamily
A4R43_35650	COG4122	O-methyltransferase activity
A4R43_35665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_35670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R43_35685	COG2239	Acts as a magnesium transporter
A4R43_35690	COG0330	HflC and HflK could
A4R43_35735	COG1309	transcriptional regulator
A4R43_35765	COG0598	Magnesium transport protein CorA
A4R43_35795	COG0613	PHP domain protein
A4R43_35800	COG2095	MarC family integral membrane protein
A4R43_35825	COG0513	Belongs to the DEAD box helicase family
A4R43_35860	COG2267	carboxylic ester hydrolase activity
A4R43_35870	COG0596	Alpha beta hydrolase
A4R43_35890	COG0243	molybdopterin cofactor binding
A4R43_35895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_35905	COG2146	nitrite reductase [NAD(P)H] activity
A4R43_35905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_35910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_35910	COG2146	nitrite reductase [NAD(P)H] activity
A4R43_35935	COG2378	regulation of single-species biofilm formation
A4R43_35955	COG0210	DNA helicase
A4R43_35995	COG0714	Associated with various cellular activities
A4R43_36030	COG0612	Peptidase, M16
A4R43_36040	COG0328	RNA-DNA hybrid ribonuclease activity
A4R43_36040	COG0406	alpha-ribazole phosphatase activity
A4R43_36090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A4R43_36095	COG3265	gluconokinase activity
A4R43_36100	COG2197	response regulator
A4R43_36200	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A4R43_36210	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_36230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4R43_36235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4R43_36235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4R43_36245	COG2318	DinB family
A4R43_36250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4R43_36255	COG3830	Belongs to the UPF0237 family
A4R43_36255	COG0560	Phosphoserine phosphatase
A4R43_36300	COG1335	isochorismatase
A4R43_36305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4R43_36310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A4R43_36320	COG3191	aminopeptidase activity
A4R43_36340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R43_36345	COG0705	Rhomboid family
A4R43_36360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4R43_36365	COG1234	tRNA 3'-trailer cleavage
A4R43_36375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4R43_36380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4R43_36405	COG1733	regulation of RNA biosynthetic process
A4R43_36455	COG0243	molybdopterin cofactor binding
A4R43_36485	COG2261	transglycosylase associated protein
A4R43_36505	COG0587	DNA-directed DNA polymerase activity
A4R43_36510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4R43_36515	COG1309	transcriptional regulator
A4R43_36525	COG2124	cytochrome p450
A4R43_36530	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
A4R43_36560	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4R43_36565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R43_36575	COG1609	Transcriptional regulator
A4R43_36580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4R43_36590	COG2223	nitrite transmembrane transporter activity
A4R43_36815	COG1309	transcriptional regulator
A4R43_36820	COG2272	Belongs to the type-B carboxylesterase lipase family
A4R43_36830	COG1295	ribonuclease BN
A4R43_36850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_36860	COG1733	regulation of RNA biosynthetic process
A4R43_36865	COG1070	Carbohydrate kinase
A4R43_36870	COG2814	Major facilitator Superfamily
A4R43_36875	COG1349	DNA-binding transcription factor activity
A4R43_36880	COG0588	phosphoglycerate mutase activity
A4R43_36885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_36890	COG2376	Dihydroxyacetone kinase
A4R43_36895	COG0698	ribose 5-phosphate isomerase
A4R43_36900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R43_36910	COG0235	Class ii aldolase
A4R43_36915	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_36920	COG0640	Transcriptional regulator
A4R43_36970	COG3706	GGDEF domain
A4R43_36970	COG0745	RESPONSE REGULATOR receiver
A4R43_36980	COG5002	protein histidine kinase activity
A4R43_36995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4R43_37005	COG0367	asparagine synthase
A4R43_37010	COG1045	serine acetyltransferase
A4R43_37015	COG1733	regulation of RNA biosynthetic process
A4R43_37020	COG3629	intracellular signal transduction
A4R43_37035	COG4585	Histidine kinase
A4R43_37045	COG2197	response regulator
A4R43_37055	COG1917	Cupin 2, conserved barrel domain protein
A4R43_37055	COG4977	sequence-specific DNA binding
A4R43_37080	COG2124	cytochrome p450
A4R43_37115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_37135	COG0477	Major facilitator Superfamily
A4R43_37145	COG1960	acyl-CoA dehydrogenase activity
A4R43_37150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_37205	COG1960	acyl-CoA dehydrogenase activity
A4R43_37210	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_37215	COG1960	acyl-CoA dehydrogenase activity
A4R43_37220	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_37230	COG1794	racemase activity, acting on amino acids and derivatives
A4R43_37245	COG0367	asparagine synthase
A4R43_37250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_37325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_37340	COG1846	Transcriptional regulator
A4R43_37395	COG3012	SEC-C Motif Domain Protein
A4R43_37405	COG0515	serine threonine protein kinase
A4R43_37430	COG0187	DNA topoisomerase II activity
A4R43_37435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4R43_37450	COG0583	DNA-binding transcription factor activity
A4R43_37470	COG0175	sulfate reduction
A4R43_37480	COG0745	RESPONSE REGULATOR receiver
A4R43_37490	COG3629	intracellular signal transduction
A4R43_37490	COG3903	Transcriptional regulator
A4R43_37500	COG2205	protein histidine kinase activity
A4R43_37510	COG0714	Associated with various cellular activities
A4R43_37555	COG3831	ATPase activity
A4R43_37560	COG0714	Associated with various cellular activities
A4R43_37565	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4R43_37570	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4R43_37575	COG4715	Zinc finger, swim domain protein
A4R43_37600	COG1522	sequence-specific DNA binding
A4R43_37615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4R43_37620	COG3629	intracellular signal transduction
A4R43_37620	COG3903	Transcriptional regulator
A4R43_37635	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_37655	COG0745	RESPONSE REGULATOR receiver
A4R43_37660	COG2205	protein histidine kinase activity
A4R43_37675	COG1136	(ABC) transporter
A4R43_37680	COG0577	efflux transmembrane transporter activity
A4R43_37765	COG0300	oxidoreductase activity
A4R43_37790	COG4991	sh3 domain protein
A4R43_37795	COG3903	Transcriptional regulator
A4R43_37795	COG3629	intracellular signal transduction
A4R43_37800	COG4991	sh3 domain protein
A4R43_37805	COG3540	Alkaline phosphatase
A4R43_37810	COG1278	Cold shock
A4R43_37825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4R43_37830	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A4R43_37845	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A4R43_37850	COG1132	(ABC) transporter
A4R43_37860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_37865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_37880	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_37890	COG0070	glutamate synthase
A4R43_37890	COG0069	glutamate synthase activity
A4R43_37890	COG0067	glutamate synthase
A4R43_37895	COG0247	lactate metabolic process
A4R43_37895	COG0277	FAD linked oxidase domain protein
A4R43_37910	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4R43_37910	COG0235	Class ii aldolase
A4R43_37915	COG0471	metal ion transport
A4R43_37920	COG0583	DNA-binding transcription factor activity
A4R43_37935	COG1960	acyl-CoA dehydrogenase activity
A4R43_37945	COG1024	Enoyl-CoA hydratase
A4R43_37950	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_37980	COG3483	tryptophan 2,3-dioxygenase activity
A4R43_38015	COG0596	Alpha beta hydrolase
A4R43_38015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4R43_38015	COG2226	methyltransferase
A4R43_38045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4R43_38065	COG2072	flavoprotein involved in K transport
A4R43_38100	COG1175	transmembrane transport
A4R43_38110	COG0366	Alpha amylase catalytic
A4R43_38120	COG1796	DNA polymerase
A4R43_38120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4R43_38130	COG3268	Saccharopine dehydrogenase
A4R43_38150	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_38155	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_38160	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_38170	COG1129	ABC transporter
A4R43_38175	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_38180	COG2186	Transcriptional regulator
A4R43_38200	COG2197	response regulator
A4R43_38245	COG0246	Mannitol dehydrogenase
A4R43_38260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A4R43_38295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_38300	COG0531	amino acid
A4R43_38335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_38335	COG1672	PFAM Archaeal ATPase
A4R43_38345	COG0667	Aldo Keto reductase
A4R43_38350	COG0583	DNA-binding transcription factor activity
A4R43_38370	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_38375	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_38380	COG0656	L-ascorbic acid biosynthetic process
A4R43_38385	COG2814	Major facilitator Superfamily
A4R43_38395	COG1793	dna ligase
A4R43_38410	COG0596	Alpha beta hydrolase
A4R43_38475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_38490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_38515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4R43_38555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4R43_38560	COG3467	pyridoxamine 5'-phosphate
A4R43_38565	COG0326	Molecular chaperone. Has ATPase activity
A4R43_38595	COG2197	response regulator
A4R43_38620	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_38640	COG0492	ferredoxin-NADP+ reductase activity
A4R43_38645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_38660	COG0640	Transcriptional regulator
A4R43_38700	COG1846	Transcriptional regulator
A4R43_38710	COG5006	permease, DMT superfamily
A4R43_38725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4R43_38740	COG1695	Transcriptional regulator
A4R43_38785	COG2223	nitrite transmembrane transporter activity
A4R43_38800	COG0629	single-stranded DNA binding
A4R43_38815	COG2902	Dehydrogenase
A4R43_38845	COG0366	Alpha amylase catalytic
A4R43_38855	COG0668	transmembrane transport
A4R43_38875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4R43_38885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4R43_38890	COG0477	Major facilitator Superfamily
A4R43_38900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_38930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4R43_39040	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4R43_39050	COG0740	serine-type endopeptidase activity
A4R43_39075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4R43_39110	COG0525	valine-tRNA ligase activity
A4R43_39130	COG2755	lipolytic protein G-D-S-L family
A4R43_39140	COG1129	ABC transporter
A4R43_39145	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_39160	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_39185	COG0285	dihydrofolate synthase activity
A4R43_39195	COG2366	antibiotic biosynthetic process
A4R43_39205	COG0105	UTP biosynthetic process
A4R43_39215	COG2186	Transcriptional regulator
A4R43_39230	COG1131	(ABC) transporter
A4R43_39240	COG0842	Transport permease protein
A4R43_39250	COG1530	ribonuclease E activity
A4R43_39250	COG1530	ribonuclease E activity
A4R43_39255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4R43_39260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4R43_39265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4R43_39290	COG1136	(ABC) transporter
A4R43_39290	COG0577	efflux transmembrane transporter activity
A4R43_39300	COG1309	transcriptional regulator
A4R43_39310	COG0477	Major facilitator Superfamily
A4R43_39315	COG0514	ATP-dependent DNA helicase (RecQ)
A4R43_39315	COG0514	ATP-dependent DNA helicase (RecQ)
A4R43_39320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4R43_39325	COG0799	negative regulation of ribosome biogenesis
A4R43_39330	COG0406	alpha-ribazole phosphatase activity
A4R43_39340	COG1307	EDD domain protein, DegV family
A4R43_39365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_39370	COG1596	polysaccharide export
A4R43_39370	COG1555	photosystem II stabilization
A4R43_39390	COG0268	Binds directly to 16S ribosomal RNA
A4R43_39430	COG0481	GTPase activity
A4R43_39450	COG2070	2-Nitropropane dioxygenase
A4R43_39455	COG0531	amino acid
A4R43_39460	COG2267	carboxylic ester hydrolase activity
A4R43_39465	COG0604	alcohol dehydrogenase
A4R43_39475	COG4290	ribonuclease
A4R43_39480	COG2732	(Barnase) inhibitor
A4R43_39485	COG1024	Enoyl-CoA hydratase
A4R43_39525	COG2197	response regulator
A4R43_39530	COG4585	Histidine kinase
A4R43_39535	COG2409	Drug exporters of the RND superfamily
A4R43_39550	COG2226	methyltransferase
A4R43_39565	COG0640	Transcriptional regulator
A4R43_39600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_39610	COG1953	Uracil, thiamine, allantoin
A4R43_39625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R43_39635	COG1420	regulation of RNA biosynthetic process
A4R43_39640	COG0484	heat shock protein binding
A4R43_39650	COG0537	adenosine 5'-monophosphoramidase activity
A4R43_39660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4R43_39675	COG3629	intracellular signal transduction
A4R43_39675	COG3903	Transcriptional regulator
A4R43_39680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4R43_39705	COG1381	Involved in DNA repair and RecF pathway recombination
A4R43_39710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4R43_39720	COG0701	Predicted permease
A4R43_39760	COG0423	glycine-tRNA ligase activity
A4R43_39765	COG1131	(ABC) transporter
A4R43_39775	COG4585	Histidine kinase
A4R43_39785	COG2197	response regulator
A4R43_39820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_39825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_39830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_39835	COG1595	DNA-templated transcription, initiation
A4R43_39850	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_39880	COG2815	serine threonine protein kinase
A4R43_39880	COG0515	serine threonine protein kinase
A4R43_39905	COG3209	COG3209 Rhs family protein
A4R43_39915	COG0583	DNA-binding transcription factor activity
A4R43_39920	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_39930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_39965	COG3848	Pyruvate phosphate dikinase
A4R43_39965	COG0574	Belongs to the PEP-utilizing enzyme family
A4R43_39970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_39990	COG0481	GTPase activity
A4R43_39990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4R43_39995	COG1414	Transcriptional regulator
A4R43_40005	COG0800	Aldolase
A4R43_40010	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_40015	COG2271	Major facilitator Superfamily
A4R43_40035	COG2272	Belongs to the type-B carboxylesterase lipase family
A4R43_40055	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_40070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4R43_40110	COG0137	argininosuccinate synthase activity
A4R43_40120	COG1309	transcriptional regulator
A4R43_40150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_40155	COG1802	Transcriptional regulator
A4R43_40185	COG2072	flavoprotein involved in K transport
A4R43_40215	COG0477	Major facilitator Superfamily
A4R43_40230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4R43_40245	COG4941	Belongs to the sigma-70 factor family
A4R43_40270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_40275	COG1120	ATPase activity
A4R43_40295	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_40320	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_40325	COG1309	transcriptional regulator
A4R43_40350	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A4R43_40350	COG0778	Nitroreductase
A4R43_40425	COG1454	alcohol dehydrogenase
A4R43_40530	COG0395	ABC-type sugar transport system, permease component
A4R43_40580	COG2072	flavoprotein involved in K transport
A4R43_40600	COG0583	DNA-binding transcription factor activity
A4R43_40660	COG1793	dna ligase
A4R43_40660	COG3285	dna ligase
A4R43_40680	COG0367	asparagine synthase
A4R43_40695	COG1940	carbohydrate kinase activity
A4R43_40700	COG2115	Belongs to the xylose isomerase family
A4R43_40745	COG0328	RNA-DNA hybrid ribonuclease activity
A4R43_40755	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_40760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_40770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_40805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_40860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4R43_40865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_40885	COG0626	cystathionine gamma-synthase activity
A4R43_40915	COG0646	methionine synthase
A4R43_40915	COG1410	methionine synthase
A4R43_40930	COG2022	thiamine diphosphate biosynthetic process
A4R43_40950	COG0667	Aldo Keto reductase
A4R43_40970	COG0702	epimerase
A4R43_40975	COG1733	regulation of RNA biosynthetic process
A4R43_40985	COG2197	response regulator
A4R43_41010	COG4942	peptidase
A4R43_41015	COG3226	Transcriptional regulator
A4R43_41030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_41045	COG0779	Required for maturation of 30S ribosomal subunits
A4R43_41060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4R43_41070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4R43_41090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4R43_41130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4R43_41150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4R43_41155	COG1185	polyribonucleotide nucleotidyltransferase activity
A4R43_41160	COG0612	Peptidase, M16
A4R43_41165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4R43_41190	COG3214	Protein conserved in bacteria
A4R43_41195	COG0477	Major facilitator Superfamily
A4R43_41205	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_41205	COG1672	PFAM Archaeal ATPase
A4R43_41235	COG0515	serine threonine protein kinase
A4R43_41235	COG2815	serine threonine protein kinase
A4R43_41240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_41245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4R43_41270	COG1674	ftsk spoiiie
A4R43_41290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4R43_41295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4R43_41305	COG1546	Belongs to the CinA family
A4R43_41305	COG1058	Belongs to the CinA family
A4R43_41310	COG1396	sequence-specific DNA binding
A4R43_41330	COG0167	dihydroorotate dehydrogenase activity
A4R43_41340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4R43_41345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4R43_41350	COG2151	metal-sulfur cluster biosynthetic enzyme
A4R43_41350	COG0489	protein tyrosine kinase activity
A4R43_41370	COG1305	Transglutaminase-like
A4R43_41380	COG0714	Associated with various cellular activities
A4R43_41405	COG2001	Belongs to the MraZ family
A4R43_41410	COG0275	rRNA processing
A4R43_41420	COG0768	penicillin binding
A4R43_41435	COG0248	Ppx GppA phosphatase
A4R43_41485	COG1476	TRANSCRIPTIONal
A4R43_41500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_41550	COG1797	cobyrinic acid a,c-diamide synthase activity
A4R43_41560	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A4R43_41575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A4R43_41580	COG1492	cobalamin metabolic process
A4R43_41605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4R43_41630	COG1522	sequence-specific DNA binding
A4R43_41645	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_41665	COG2226	methyltransferase
A4R43_41670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_41685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R43_41700	COG1132	(ABC) transporter
A4R43_41705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R43_41720	COG3537	Alpha-1,2-mannosidase
A4R43_41730	COG0514	ATP-dependent DNA helicase (RecQ)
A4R43_41745	COG4221	oxidoreductase activity
A4R43_41750	COG3199	ATP-NAD kinase
A4R43_41755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4R43_41770	COG1063	alcohol dehydrogenase
A4R43_41830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_41835	COG2318	DinB family