locus-tag	class	description
B737_0002	COG0592	DNA-directed DNA polymerase activity
B737_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B737_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B737_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B737_0006	COG0187	DNA topoisomerase II activity
B737_0026	COG0596	Alpha beta hydrolase
B737_0035	COG0705	Rhomboid family
B737_0035	COG0457	Tetratricopeptide repeat
B737_0037	COG3764	Sortase (surface protein transpeptidase)
B737_0049	COG2815	serine threonine protein kinase
B737_0049	COG0515	serine threonine protein kinase
B737_0050	COG0515	serine threonine protein kinase
B737_0051	COG0768	penicillin binding
B737_0054	COG1716	ATPase activity
B737_0055	COG1716	ATPase activity
B737_0060	COG0626	cystathionine gamma-synthase activity
B737_0064	COG2186	Transcriptional regulator
B737_0065	COG0747	negative chemotaxis
B737_0068	COG0444	Belongs to the ABC transporter superfamily
B737_0069	COG4608	Belongs to the ABC transporter superfamily
B737_0070	COG1012	belongs to the aldehyde dehydrogenase family
B737_0071	COG1028	Short-chain dehydrogenase reductase Sdr
B737_0072	COG0154	amidase activity
B737_0077	COG2301	Belongs to the HpcH HpaI aldolase family
B737_0079	COG0702	epimerase
B737_0081	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B737_0083	COG1309	transcriptional regulator
B737_0085	COG2211	Major facilitator Superfamily
B737_0091	COG1276	copper resistance
B737_0091	COG2372	response to copper ion
B737_0094	COG1174	glycine betaine transport
B737_0096	COG1174	glycine betaine transport
B737_0101	COG2226	methyltransferase
B737_0103	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B737_0105	COG0405	Gamma-glutamyltransferase
B737_0106	COG5433	transposase activity
B737_0109	COG0477	Major facilitator Superfamily
B737_0111	COG4585	Histidine kinase
B737_0112	COG2197	response regulator
B737_0118	COG0438	transferase activity, transferring glycosyl groups
B737_0128	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B737_0129	COG3275	phosphorelay sensor kinase activity
B737_0134	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B737_0135	COG0425	Belongs to the sulfur carrier protein TusA family
B737_0135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B737_0139	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B737_0143	COG1191	sigma factor activity
B737_0146	COG2235	arginine
B737_0161	COG1271	oxidase subunit
B737_0162	COG1294	oxidase, subunit
B737_0163	COG4988	ABC transporter
B737_0174	COG4715	Zinc finger, swim domain protein
B737_0176	COG1072	(Pantothenic acid kinase))
B737_0177	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B737_0179	COG0406	alpha-ribazole phosphatase activity
B737_0186	COG0754	glutathionylspermidine amidase activity
B737_0188	COG0596	Alpha beta hydrolase
B737_0189	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B737_0190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B737_0191	COG0579	oxidoreductase
B737_0197	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B737_0200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B737_0206	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B737_0208	COG1028	Short-chain dehydrogenase reductase Sdr
B737_0209	COG0318	PFAM AMP-dependent synthetase and ligase
B737_0217	COG0561	phosphatase activity
B737_0218	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_0222	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B737_0225	COG1028	Short-chain dehydrogenase reductase Sdr
B737_0226	COG0277	FAD linked oxidase domain protein
B737_0228	COG1216	Glycosyl transferase, family 2
B737_0234	COG1216	Glycosyl transferase, family 2
B737_0238	COG3321	synthase
B737_0238	COG0604	alcohol dehydrogenase
B737_0238	COG1028	Short-chain dehydrogenase reductase Sdr
B737_0240	COG2234	aminopeptidase activity
B737_0251	COG4565	transcriptional regulatory protein
B737_0252	COG3290	protein histidine kinase activity
B737_0253	COG1116	anion transmembrane transporter activity
B737_0258	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B737_0258	COG1672	PFAM Archaeal ATPase
B737_0261	COG1522	sequence-specific DNA binding
B737_0263	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B737_0264	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B737_0265	COG2186	Transcriptional regulator
B737_0268	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B737_0270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B737_0274	COG3469	chitinase activity
B737_0275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B737_0280	COG3584	3D domain protein
B737_0280	COG3583	domain protein
B737_0293	COG3559	Exporter of polyketide antibiotics
B737_0295	COG1131	(ABC) transporter
B737_0306	COG0287	Prephenate dehydrogenase
B737_0307	COG0446	pyridine nucleotide-disulphide oxidoreductase
B737_0307	COG1902	pentaerythritol trinitrate reductase activity
B737_0311	COG1846	Transcriptional regulator
B737_0317	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B737_0319	COG2318	DinB family
B737_0321	COG0194	GDP metabolic process
B737_0332	COG0515	serine threonine protein kinase
B737_0335	COG0028	Belongs to the TPP enzyme family
B737_0338	COG3199	ATP-NAD kinase
B737_0339	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B737_0342	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B737_0343	COG0515	serine threonine protein kinase
B737_0345	COG0477	Major facilitator Superfamily
B737_0346	COG1595	DNA-templated transcription, initiation
B737_0349	COG1278	Cold shock
B737_0380	COG2226	methyltransferase
B737_0387	COG2233	PERMEase
B737_0389	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B737_0391	COG1414	Transcriptional regulator
B737_0395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B737_0413	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B737_0416	COG2364	Membrane
B737_0418	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_0421	COG2733	membrane
B737_0426	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B737_0432	COG2986	histidine ammonia-lyase
B737_0437	COG1174	glycine betaine transport
B737_0440	COG1846	Transcriptional regulator
B737_0443	COG2130	NADP-dependent
B737_0445	COG1064	alcohol dehydrogenase
B737_0451	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B737_0454	COG0438	transferase activity, transferring glycosyl groups
B737_0457	COG0588	phosphoglycerate mutase activity
B737_0459	COG0667	Aldo Keto reductase
B737_0460	COG5002	protein histidine kinase activity
B737_0466	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B737_0470	COG4585	Histidine kinase
B737_0473	COG0560	Phosphoserine phosphatase
B737_0475	COG1595	DNA-templated transcription, initiation
B737_0476	COG0318	PFAM AMP-dependent synthetase and ligase
B737_0479	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B737_0480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B737_0481	COG0181	hydroxymethylbilane synthase activity
B737_0482	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B737_0482	COG1648	precorrin-2 dehydrogenase activity
B737_0489	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B737_0490	COG1136	(ABC) transporter
B737_0490	COG0577	efflux transmembrane transporter activity
B737_0491	COG1136	(ABC) transporter
B737_0491	COG0577	efflux transmembrane transporter activity
B737_0494	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B737_0495	COG0406	alpha-ribazole phosphatase activity
B737_0496	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B737_0497	COG0785	Cytochrome C biogenesis protein
B737_0499	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B737_0503	COG1522	sequence-specific DNA binding
B737_0509	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B737_0514	COG0438	transferase activity, transferring glycosyl groups
B737_0517	COG2226	methyltransferase
B737_0518	COG0644	oxidoreductase
B737_0520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B737_0521	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B737_0522	COG0649	NAD binding
B737_0525	COG1034	ATP synthesis coupled electron transport
B737_0526	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B737_0527	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B737_0528	COG0839	Belongs to the complex I subunit 6 family
B737_0529	COG0713	ATP synthesis coupled electron transport
B737_0530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B737_0532	COG1007	ATP synthesis coupled electron transport
B737_0539	COG1013	pyruvate-flavodoxin oxidoreductase activity
B737_0540	COG0674	pyruvate-flavodoxin oxidoreductase activity
B737_0540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B737_0542	COG1522	sequence-specific DNA binding
B737_0543	COG1834	amidinotransferase
B737_0546	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B737_0547	COG0438	transferase activity, transferring glycosyl groups
B737_0550	COG0367	asparagine synthase
B737_0559	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B737_0560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B737_0562	COG1215	transferase activity, transferring glycosyl groups
B737_0564	COG4310	Domain of unknown function (DUF2172)
B737_0567	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B737_0570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_0578	COG1666	GTP binding
B737_0581	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B737_0585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B737_0586	COG2030	dehydratase
B737_0590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_0594	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B737_0595	COG0081	regulation of translation
B737_0598	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B737_0602	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B737_0607	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B737_0612	COG0673	inositol 2-dehydrogenase activity
B737_0624	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B737_0625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B737_0628	COG0546	phosphoglycolate phosphatase activity
B737_0630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B737_0632	COG0477	Major facilitator Superfamily
B737_0635	COG2124	cytochrome p450
B737_0636	COG2124	cytochrome p450
B737_0640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B737_0643	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_0648	COG2124	cytochrome p450
B737_0650	COG3959	Transketolase, thiamine diphosphate binding domain
B737_0651	COG3958	Transketolase
B737_0653	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B737_0656	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B737_0658	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B737_0659	COG1522	sequence-specific DNA binding
B737_0660	COG0477	Major facilitator Superfamily
B737_0662	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B737_0662	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_0671	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B737_0672	COG0049	tRNA binding
B737_0673	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B737_0675	COG0051	transcription antitermination factor activity, RNA binding
B737_0676	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B737_0677	COG0088	Forms part of the polypeptide exit tunnel
B737_0678	COG0089	rRNA binding
B737_0679	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B737_0680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B737_0681	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B737_0682	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B737_0683	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B737_0684	COG0255	Belongs to the universal ribosomal protein uL29 family
B737_0685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B737_0686	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B737_0687	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B737_0688	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B737_0690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B737_0691	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B737_0692	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B737_0693	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B737_0694	COG1841	ribosomal large subunit assembly
B737_0695	COG0200	Binds to the 23S rRNA
B737_0697	COG1280	lysine exporter protein (LysE YggA)
B737_0699	COG0563	adenylate kinase activity
B737_0702	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B737_0703	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B737_0705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B737_0706	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B737_0707	COG0202	RNA polymerase activity
B737_0708	COG0203	ribosomal protein L17
B737_0709	COG0101	tRNA pseudouridine synthase activity
B737_0716	COG1404	Belongs to the peptidase S8 family
B737_0718	COG1674	ftsk spoiiie
B737_0719	COG0443	Heat shock 70 kDa protein
B737_0725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B737_0726	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B737_0728	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B737_0737	COG1349	DNA-binding transcription factor activity
B737_0738	COG1070	Carbohydrate kinase
B737_0739	COG3842	ATPase activity
B737_0740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B737_0742	COG0802	atpase or kinase
B737_0744	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B737_0744	COG0825	malonyl-CoA metabolic process
B737_0745	COG0318	PFAM AMP-dependent synthetase and ligase
B737_0747	COG0456	acetyltransferase
B737_0748	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B737_0749	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B737_0753	COG1215	transferase activity, transferring glycosyl groups
B737_0755	COG2226	methyltransferase
B737_0758	COG0798	PFAM Bile acid sodium symporter
B737_0759	COG0640	Transcriptional regulator
B737_0761	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B737_0762	COG0459	protein refolding
B737_0773	COG0516	GMP reductase activity
B737_0776	COG0277	FAD linked oxidase domain protein
B737_0777	COG1012	belongs to the aldehyde dehydrogenase family
B737_0781	COG0519	Catalyzes the synthesis of GMP from XMP
B737_0781	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B737_0784	COG1028	Short-chain dehydrogenase reductase Sdr
B737_0787	COG0697	spore germination
B737_0790	COG0583	DNA-binding transcription factor activity
B737_0791	COG0515	serine threonine protein kinase
B737_0791	COG2815	serine threonine protein kinase
B737_0801	COG0045	succinate-CoA ligase (ADP-forming) activity
B737_0806	COG0138	bifunctional purine biosynthesis protein purh
B737_0815	COG0587	DNA-directed DNA polymerase activity
B737_0818	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B737_0820	COG2814	Major facilitator Superfamily
B737_0821	COG0640	Transcriptional regulator
B737_0823	COG2814	Major facilitator Superfamily
B737_0824	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B737_0829	COG2226	methyltransferase
B737_0836	COG1234	tRNA 3'-trailer cleavage
B737_0839	COG0180	Tryptophanyl-tRNA synthetase
B737_0841	COG1295	ribonuclease BN
B737_0844	COG1733	regulation of RNA biosynthetic process
B737_0848	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B737_0851	COG2009	succinate dehydrogenase
B737_0852	COG3345	alpha-galactosidase
B737_0853	COG1082	Xylose isomerase domain protein TIM barrel
B737_0861	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B737_0862	COG2271	Major facilitator Superfamily
B737_0866	COG1733	regulation of RNA biosynthetic process
B737_0868	COG1063	alcohol dehydrogenase
B737_0871	COG0395	ABC-type sugar transport system, permease component
B737_0878	COG1012	belongs to the aldehyde dehydrogenase family
B737_0879	COG1012	belongs to the aldehyde dehydrogenase family
B737_0880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B737_0888	COG0789	Transcriptional regulator
B737_0889	COG0667	Aldo Keto reductase
B737_0893	COG0475	glutathione-regulated potassium exporter activity
B737_0894	COG0745	RESPONSE REGULATOR receiver
B737_0895	COG2205	protein histidine kinase activity
B737_0899	COG0402	S-adenosylhomocysteine deaminase activity
B737_0904	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B737_0909	COG0515	serine threonine protein kinase
B737_0915	COG1473	amidohydrolase
B737_0915	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B737_0923	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B737_0924	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B737_0925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B737_0932	COG4770	biotin carboxylase activity
B737_0935	COG1301	dicarboxylic acid transport
B737_0936	COG0424	maF-like protein
B737_0937	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_0941	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_0943	COG1846	Transcriptional regulator
B737_0944	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B737_0947	COG4585	Histidine kinase
B737_0950	COG1309	transcriptional regulator
B737_0952	COG1733	regulation of RNA biosynthetic process
B737_0955	COG1028	Short-chain dehydrogenase reductase Sdr
B737_0957	COG0583	DNA-binding transcription factor activity
B737_0961	COG2226	methyltransferase
B737_0964	COG0446	pyridine nucleotide-disulphide oxidoreductase
B737_0964	COG1902	pentaerythritol trinitrate reductase activity
B737_0967	COG4585	Histidine kinase
B737_0968	COG2197	response regulator
B737_0969	COG0791	NLP P60 protein
B737_0969	COG1388	LysM domain
B737_0969	COG3103	Sh3 type 3 domain protein
B737_0972	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B737_0975	COG3537	Alpha-1,2-mannosidase
B737_0976	COG0483	inositol monophosphate 1-phosphatase activity
B737_0978	COG2205	protein histidine kinase activity
B737_0979	COG2197	response regulator
B737_0980	COG2197	response regulator
B737_0992	COG0318	PFAM AMP-dependent synthetase and ligase
B737_0996	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B737_1001	COG1316	TRANSCRIPTIONal
B737_1003	COG1316	TRANSCRIPTIONal
B737_1009	COG0438	transferase activity, transferring glycosyl groups
B737_1016	COG1725	Transcriptional regulator
B737_1019	COG0778	Nitroreductase
B737_1019	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B737_1038	COG1611	Belongs to the LOG family
B737_1041	COG1216	Glycosyl transferase, family 2
B737_1046	COG1132	(ABC) transporter
B737_1047	COG0463	Glycosyl transferase, family 2
B737_1048	COG4988	ABC transporter
B737_1049	COG1294	oxidase, subunit
B737_1050	COG1271	oxidase subunit
B737_1055	COG2818	Glycosylase
B737_1056	COG1024	Enoyl-CoA hydratase
B737_1058	COG0583	DNA-binding transcription factor activity
B737_1059	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B737_1060	COG2814	Major facilitator Superfamily
B737_1062	COG4122	O-methyltransferase activity
B737_1063	COG1595	DNA-templated transcription, initiation
B737_1065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B737_1066	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B737_1069	COG2239	Acts as a magnesium transporter
B737_1072	COG0330	HflC and HflK could
B737_1082	COG1309	transcriptional regulator
B737_1084	COG2197	response regulator
B737_1085	COG4585	Histidine kinase
B737_1091	COG0598	Magnesium transport protein CorA
B737_1097	COG0613	PHP domain protein
B737_1098	COG2095	MarC family integral membrane protein
B737_1103	COG0513	Belongs to the DEAD box helicase family
B737_1109	COG2267	carboxylic ester hydrolase activity
B737_1110	COG1309	transcriptional regulator
B737_1111	COG2267	carboxylic ester hydrolase activity
B737_1115	COG0243	molybdopterin cofactor binding
B737_1116	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B737_1118	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B737_1118	COG2146	nitrite reductase [NAD(P)H] activity
B737_1119	COG2146	nitrite reductase [NAD(P)H] activity
B737_1119	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B737_1124	COG2378	regulation of single-species biofilm formation
B737_1136	COG0714	Associated with various cellular activities
B737_1141	COG2321	neutral zinc metallopeptidase
B737_1145	COG0612	Peptidase, M16
B737_1149	COG1175	transmembrane transport
B737_1150	COG0395	ABC-type sugar transport system, permease component
B737_1151	COG1486	melibiose metabolic process
B737_1154	COG0640	Transcriptional regulator
B737_1157	COG3265	gluconokinase activity
B737_1159	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B737_1166	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B737_1168	COG0328	RNA-DNA hybrid ribonuclease activity
B737_1168	COG0406	alpha-ribazole phosphatase activity
B737_1169	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B737_1188	COG1012	belongs to the aldehyde dehydrogenase family
B737_1195	COG1012	belongs to the aldehyde dehydrogenase family
B737_1196	COG3842	ATPase activity
B737_1197	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B737_1198	COG1176	ABC-type spermidine putrescine transport system, permease component I
B737_1199	COG1177	transmembrane transport
B737_1200	COG0596	Alpha beta hydrolase
B737_1201	COG1968	undecaprenyl-diphosphatase activity
B737_1203	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B737_1204	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B737_1204	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B737_1206	COG2318	DinB family
B737_1208	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B737_1208	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B737_1210	COG0653	protein targeting
B737_1214	COG0174	glutamine synthetase
B737_1215	COG0154	amidase activity
B737_1216	COG1522	sequence-specific DNA binding
B737_1218	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B737_1218	COG0519	Catalyzes the synthesis of GMP from XMP
B737_1221	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B737_1223	COG0174	glutamine synthetase
B737_1234	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B737_1239	COG3480	Lon protease (S16) C-terminal proteolytic domain
B737_1240	COG1615	UPF0182 protein
B737_1244	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B737_1245	COG2884	Cell division ATP-binding protein ftsE
B737_1246	COG2177	Part of the ABC transporter FtsEX involved in
B737_1247	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B737_1251	COG2197	response regulator
B737_1253	COG4585	Histidine kinase
B737_1255	COG3706	GGDEF domain
B737_1258	COG2986	histidine ammonia-lyase
B737_1259	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B737_1261	COG0402	S-adenosylhomocysteine deaminase activity
B737_1262	COG1228	amidohydrolase
B737_1264	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_1270	COG4585	Histidine kinase
B737_1276	COG1131	(ABC) transporter
B737_1277	COG1643	Atp-dependent helicase
B737_1278	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B737_1282	COG0791	NLP P60 protein
B737_1282	COG3883	PFAM NLP P60 protein
B737_1284	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_1287	COG2318	DinB family
B737_1288	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_1290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B737_1291	COG0187	DNA topoisomerase II activity
B737_1300	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_1301	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_1302	COG1129	ABC transporter
B737_1303	COG1879	ABC-type sugar transport system periplasmic component
B737_1304	COG1609	Transcriptional regulator
B737_1305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B737_1307	COG1028	Short-chain dehydrogenase reductase Sdr
B737_1311	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B737_1317	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B737_1323	COG1028	Short-chain dehydrogenase reductase Sdr
B737_1325	COG0017	Asparaginyl-tRNA synthetase
B737_1329	COG0596	Alpha beta hydrolase
B737_1334	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B737_1336	COG1486	melibiose metabolic process
B737_1337	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_1338	COG1053	succinate dehydrogenase
B737_1339	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B737_1341	COG0596	Alpha beta hydrolase
B737_1358	COG0697	spore germination
B737_1359	COG1846	Transcriptional regulator
B737_1366	COG3629	intracellular signal transduction
B737_1366	COG3903	Transcriptional regulator
B737_1368	COG2211	Major facilitator Superfamily
B737_1369	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B737_1370	COG0411	ABC transporter
B737_1371	COG0410	ABC transporter
B737_1375	COG1309	transcriptional regulator
B737_1381	COG1136	(ABC) transporter
B737_1391	COG0477	Major facilitator Superfamily
B737_1395	COG3387	PFAM Glycoside hydrolase 15-related
B737_1396	COG1063	alcohol dehydrogenase
B737_1400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_1410	COG3209	COG3209 Rhs family protein
B737_1417	COG3321	synthase
B737_1417	COG1028	Short-chain dehydrogenase reductase Sdr
B737_1417	COG0604	alcohol dehydrogenase
B737_1423	COG2018	Roadblock/LC7 domain
B737_1428	COG1028	Short-chain dehydrogenase reductase Sdr
B737_1429	COG0583	DNA-binding transcription factor activity
B737_1430	COG1028	Short-chain dehydrogenase reductase Sdr
B737_1431	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_1439	COG0667	Aldo Keto reductase
B737_1441	COG1595	DNA-templated transcription, initiation
B737_1445	COG3903	Transcriptional regulator
B737_1445	COG3629	intracellular signal transduction
B737_1447	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B737_1453	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B737_1454	COG0318	PFAM AMP-dependent synthetase and ligase
B737_1462	COG1234	tRNA 3'-trailer cleavage
B737_1464	COG3852	Histidine kinase
B737_1465	COG2272	Belongs to the type-B carboxylesterase lipase family
B737_1475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B737_1491	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B737_1492	COG0765	amino acid transport
B737_1493	COG1126	abc transporter atp-binding protein
B737_1494	COG2964	Protein conserved in bacteria
B737_1497	COG0596	Alpha beta hydrolase
B737_1498	COG1131	(ABC) transporter
B737_1504	COG2186	Transcriptional regulator
B737_1505	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_1506	COG1129	ABC transporter
B737_1510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_1510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_1511	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_1514	COG1879	ABC-type sugar transport system periplasmic component
B737_1518	COG3629	intracellular signal transduction
B737_1518	COG3903	Transcriptional regulator
B737_1520	COG3540	Alkaline phosphatase
B737_1522	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B737_1524	COG3408	Glycogen debranching enzyme
B737_1524	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B737_1525	COG1940	carbohydrate kinase activity
B737_1529	COG4221	oxidoreductase activity
B737_1530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B737_1534	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B737_1537	COG0513	Belongs to the DEAD box helicase family
B737_1542	COG2183	response to ionizing radiation
B737_1545	COG2072	flavoprotein involved in K transport
B737_1554	COG1012	belongs to the aldehyde dehydrogenase family
B737_1554	COG2030	dehydratase
B737_1555	COG3396	Phenylacetate-CoA oxygenase
B737_1556	COG3460	Phenylacetate-CoA oxygenase
B737_1557	COG3396	Phenylacetate-CoA oxygenase
B737_1558	COG2151	metal-sulfur cluster biosynthetic enzyme
B737_1560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B737_1562	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B737_1569	COG0183	Belongs to the thiolase family
B737_1572	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_1573	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B737_1574	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B737_1575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B737_1577	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B737_1579	COG3279	Response regulator of the LytR AlgR family
B737_1580	COG3275	phosphorelay sensor kinase activity
B737_1582	COG1879	ABC-type sugar transport system periplasmic component
B737_1583	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_1586	COG1609	Transcriptional regulator
B737_1587	COG3537	Alpha-1,2-mannosidase
B737_1588	COG3537	Alpha-1,2-mannosidase
B737_1590	COG1846	Transcriptional regulator
B737_1595	COG0058	SHG alpha-glucan phosphorylase activity
B737_1600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_1603	COG1119	ATPase activity
B737_1604	COG1024	Enoyl-CoA hydratase
B737_1605	COG2226	methyltransferase
B737_1609	COG3979	chitinase
B737_1611	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_1618	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_1619	COG0667	Aldo Keto reductase
B737_1620	COG0791	NLP P60 protein
B737_1620	COG3883	PFAM NLP P60 protein
B737_1621	COG1957	nucleoside hydrolase
B737_1622	COG0110	maltose O-acetyltransferase activity
B737_1636	COG3250	beta-galactosidase activity
B737_1637	COG0386	Belongs to the glutathione peroxidase family
B737_1639	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B737_1640	COG1307	EDD domain protein, DegV family
B737_1643	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B737_1647	COG2197	response regulator
B737_1650	COG0482	sulfurtransferase activity
B737_1654	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B737_1658	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B737_1661	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B737_1662	COG0154	amidase activity
B737_1663	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B737_1668	COG0673	inositol 2-dehydrogenase activity
B737_1670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B737_1672	COG0129	dihydroxy-acid dehydratase activity
B737_1675	COG0440	acetolactate synthase activity
B737_1676	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B737_1684	COG1404	Belongs to the peptidase S8 family
B737_1685	COG0473	3-isopropylmalate dehydrogenase activity
B737_1686	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B737_1687	COG0179	Fumarylacetoacetate (FAA) hydrolase
B737_1691	COG3903	Transcriptional regulator
B737_1691	COG3629	intracellular signal transduction
B737_1701	COG0776	regulation of translation
B737_1703	COG0420	3'-5' exonuclease activity
B737_1704	COG0419	ATPase involved in DNA repair
B737_1711	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B737_1712	COG0066	3-isopropylmalate dehydratase activity
B737_1714	COG3629	intracellular signal transduction
B737_1714	COG3903	Transcriptional regulator
B737_1719	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B737_1721	COG0252	asparaginase activity
B737_1723	COG1477	protein flavinylation
B737_1726	COG0745	RESPONSE REGULATOR receiver
B737_1728	COG2205	protein histidine kinase activity
B737_1729	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_1734	COG3345	alpha-galactosidase
B737_1736	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B737_1737	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B737_1739	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B737_1740	COG1461	Dihydroxyacetone kinase
B737_1746	COG1404	Belongs to the peptidase S8 family
B737_1747	COG5433	transposase activity
B737_1749	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B737_1763	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B737_1768	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B737_1770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_1771	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_1773	COG0542	response to heat
B737_1774	COG4249	Peptidase C14 caspase catalytic subunit p20
B737_1774	COG2319	Wd-40 repeat
B737_1775	COG3973	AAA domain
B737_1776	COG0742	ribosomal rna small subunit methyltransferase
B737_1777	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B737_1783	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B737_1784	COG0571	ribonuclease III activity
B737_1786	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B737_1790	COG3386	PFAM SMP-30 Gluconolaconase
B737_1796	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B737_1797	COG1012	belongs to the aldehyde dehydrogenase family
B737_1801	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B737_1801	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B737_1802	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B737_1803	COG0509	glycine decarboxylation via glycine cleavage system
B737_1804	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B737_1805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B737_1806	COG1760	l-serine dehydratase
B737_1807	COG2442	InterPro IPR007367
B737_1809	COG2186	Transcriptional regulator
B737_1810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B737_1812	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_1817	COG0789	Transcriptional regulator
B737_1819	COG2814	Major facilitator Superfamily
B737_1821	COG0179	Fumarylacetoacetate (FAA) hydrolase
B737_1822	COG4948	Mandelate Racemase Muconate Lactonizing
B737_1823	COG1028	Short-chain dehydrogenase reductase Sdr
B737_1825	COG1129	ABC transporter
B737_1826	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_1827	COG2186	Transcriptional regulator
B737_1836	COG1929	Belongs to the glycerate kinase type-1 family
B737_1837	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B737_1839	COG1940	carbohydrate kinase activity
B737_1840	COG1653	transport
B737_1842	COG0395	ABC-type sugar transport system, permease component
B737_1843	COG3345	alpha-galactosidase
B737_1844	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B737_1845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B737_1846	COG0183	Belongs to the thiolase family
B737_1847	COG3485	protocatechuate 3,4-dioxygenase
B737_1848	COG3485	protocatechuate 3,4-dioxygenase
B737_1849	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B737_1851	COG1414	Transcriptional regulator
B737_1852	COG0746	molybdenum cofactor guanylyltransferase activity
B737_1853	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B737_1861	COG3706	GGDEF domain
B737_1863	COG0667	Aldo Keto reductase
B737_1867	COG3962	Belongs to the TPP enzyme family
B737_1869	COG3718	enzyme involved in inositol metabolism
B737_1871	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B737_1875	COG1082	Xylose isomerase domain protein TIM barrel
B737_1877	COG0673	inositol 2-dehydrogenase activity
B737_1878	COG0367	asparagine synthase
B737_1879	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B737_1880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B737_1881	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B737_1888	COG1254	Belongs to the acylphosphatase family
B737_1891	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B737_1892	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B737_1896	COG1414	Transcriptional regulator
B737_1904	COG3835	regulator
B737_1908	COG3345	alpha-galactosidase
B737_1909	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B737_1910	COG1309	transcriptional regulator
B737_1916	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B737_1917	COG4266	Belongs to the allantoicase family
B737_1918	COG1832	CoA-binding protein
B737_1924	COG1595	DNA-templated transcription, initiation
B737_1928	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B737_1932	COG3706	GGDEF domain
B737_1933	COG1028	Short-chain dehydrogenase reductase Sdr
B737_1934	COG1309	transcriptional regulator
B737_1936	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B737_1938	COG1132	(ABC) transporter
B737_1943	COG0228	four-way junction DNA binding
B737_1947	COG0336	Belongs to the RNA methyltransferase TrmD family
B737_1948	COG0335	large ribosomal subunit rRNA binding
B737_1949	COG0681	Belongs to the peptidase S26 family
B737_1950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B737_1952	COG0792	nuclease activity
B737_1953	COG0606	chelatase, subunit chli
B737_1957	COG1191	sigma factor activity
B737_1959	COG0052	Belongs to the universal ribosomal protein uS2 family
B737_1960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B737_1961	COG0528	UMP kinase activity
B737_1962	COG0233	cytoplasmic translational termination
B737_1965	COG1695	Transcriptional regulator
B737_1967	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B737_1968	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B737_1969	COG1120	ATPase activity
B737_1970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B737_1972	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B737_1973	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B737_1983	COG0402	S-adenosylhomocysteine deaminase activity
B737_1986	COG0402	S-adenosylhomocysteine deaminase activity
B737_1994	COG0789	Transcriptional regulator
B737_1998	COG3795	YCII-related domain
B737_2002	COG1476	TRANSCRIPTIONal
B737_2004	COG3795	YCII-related domain
B737_2005	COG4941	Belongs to the sigma-70 factor family
B737_2008	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B737_2011	COG1028	Short-chain dehydrogenase reductase Sdr
B737_2016	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B737_2019	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B737_2021	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B737_2023	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B737_2029	COG0454	-acetyltransferase
B737_2029	COG0456	acetyltransferase
B737_2036	COG2186	Transcriptional regulator
B737_2043	COG0513	Belongs to the DEAD box helicase family
B737_2050	COG0583	DNA-binding transcription factor activity
B737_2052	COG3022	response to hydroperoxide
B737_2053	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B737_2060	COG0442	prolyl-tRNA aminoacylation
B737_2062	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B737_2072	COG1017	nitric oxide dioxygenase activity
B737_2072	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B737_2074	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B737_2075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B737_2076	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B737_2085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B737_2089	COG4152	abc transporter atp-binding protein
B737_2090	COG1668	transmembrane transport
B737_2092	COG1620	l-lactate permease
B737_2093	COG3201	nicotinamide mononucleotide transporter
B737_2096	COG1028	Short-chain dehydrogenase reductase Sdr
B737_2097	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B737_2116	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B737_2121	COG0477	Major facilitator Superfamily
B737_2125	COG1960	acyl-CoA dehydrogenase activity
B737_2126	COG1104	cysteine desulfurase activity
B737_2130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B737_2133	COG1113	amino acid transport
B737_2134	COG2186	Transcriptional regulator
B737_2135	COG0587	DNA-directed DNA polymerase activity
B737_2136	COG0477	Major facilitator Superfamily
B737_2140	COG0586	Pfam SNARE associated Golgi protein
B737_2141	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B737_2144	COG1309	transcriptional regulator
B737_2146	COG0321	lipoyl(octanoyl) transferase activity
B737_2148	COG1090	epimerase
B737_2150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B737_2160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B737_2163	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B737_2163	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B737_2165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B737_2166	COG0667	Aldo Keto reductase
B737_2172	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B737_2179	COG1845	cytochrome c oxidase, subunit III
B737_2180	COG2010	Cytochrome c
B737_2182	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B737_2189	COG0438	transferase activity, transferring glycosyl groups
B737_2191	COG2124	cytochrome p450
B737_2192	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B737_2193	COG0659	secondary active sulfate transmembrane transporter activity
B737_2194	COG0659	secondary active sulfate transmembrane transporter activity
B737_2195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B737_2198	COG0501	Belongs to the peptidase M48B family
B737_2199	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B737_2201	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B737_2202	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B737_2203	COG0157	Belongs to the NadC ModD family
B737_2204	COG1404	Belongs to the peptidase S8 family
B737_2212	COG0318	PFAM AMP-dependent synthetase and ligase
B737_2215	COG1674	ftsk spoiiie
B737_2220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B737_2222	COG5520	Belongs to the glycosyl hydrolase 30 family
B737_2225	COG4566	intracellular signal transduction
B737_2226	COG2197	response regulator
B737_2228	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B737_2231	COG0131	Imidazoleglycerol-phosphate dehydratase
B737_2233	COG2267	carboxylic ester hydrolase activity
B737_2234	COG2409	Drug exporters of the RND superfamily
B737_2235	COG1309	transcriptional regulator
B737_2236	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B737_2238	COG3959	Transketolase, thiamine diphosphate binding domain
B737_2239	COG3958	Transketolase
B737_2242	COG1960	acyl-CoA dehydrogenase activity
B737_2244	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B737_2246	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B737_2257	COG0107	imidazoleglycerol-phosphate synthase activity
B737_2259	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B737_2266	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B737_2268	COG0134	indole-3-glycerol-phosphate synthase activity
B737_2269	COG0133	tryptophan synthase activity
B737_2270	COG0159	tryptophan synthase activity
B737_2271	COG0789	Transcriptional regulator
B737_2275	COG0174	glutamine synthetase
B737_2278	COG1473	amidohydrolase
B737_2279	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B737_2281	COG0069	glutamate synthase activity
B737_2281	COG0070	glutamate synthase
B737_2281	COG0067	glutamate synthase
B737_2285	COG0596	Alpha beta hydrolase
B737_2286	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B737_2289	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_2291	COG2268	Band 7 protein
B737_2293	COG0515	serine threonine protein kinase
B737_2293	COG2815	serine threonine protein kinase
B737_2310	COG0242	peptide deformylase activity
B737_2311	COG1201	RNA secondary structure unwinding
B737_2312	COG1349	DNA-binding transcription factor activity
B737_2314	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B737_2318	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B737_2319	COG2137	regulation of response to DNA damage stimulus
B737_2323	COG0800	Aldolase
B737_2327	COG1053	succinate dehydrogenase
B737_2333	COG1028	Short-chain dehydrogenase reductase Sdr
B737_2334	COG0765	amino acid transport
B737_2335	COG0765	amino acid transport
B737_2336	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B737_2337	COG1126	abc transporter atp-binding protein
B737_2338	COG0745	RESPONSE REGULATOR receiver
B737_2340	COG3850	Histidine kinase
B737_2340	COG0642	Histidine kinase
B737_2341	COG1733	regulation of RNA biosynthetic process
B737_2354	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B737_2357	COG1196	nuclear chromosome segregation
B737_2358	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B737_2360	COG0525	valine-tRNA ligase activity
B737_2363	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B737_2367	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B737_2368	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B737_2372	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B737_2373	COG1505	serine-type exopeptidase activity
B737_2381	COG2936	dipeptidyl-peptidase activity
B737_2382	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B737_2384	COG2197	response regulator
B737_2385	COG4585	Histidine kinase
B737_2388	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B737_2389	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B737_2392	COG0123	including yeast histone deacetylase and acetoin utilization protein
B737_2394	COG1960	acyl-CoA dehydrogenase activity
B737_2396	COG1960	acyl-CoA dehydrogenase activity
B737_2398	COG1028	Short-chain dehydrogenase reductase Sdr
B737_2400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B737_2401	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B737_2411	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_2414	COG1609	Transcriptional regulator
B737_2417	COG0395	ABC-type sugar transport system, permease component
B737_2418	COG2723	6-phospho-beta-galactosidase activity
B737_2423	COG0003	Pfam Anion-transporting ATPase
B737_2425	COG1940	carbohydrate kinase activity
B737_2427	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B737_2433	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B737_2440	COG0640	Transcriptional regulator
B737_2444	COG1946	Acyl-CoA thioesterase
B737_2448	COG2197	response regulator
B737_2449	COG1012	belongs to the aldehyde dehydrogenase family
B737_2452	COG1960	acyl-CoA dehydrogenase activity
B737_2453	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_2458	COG1566	PFAM secretion protein HlyD family protein
B737_2461	COG1309	transcriptional regulator
B737_2462	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B737_2465	COG2018	Roadblock/LC7 domain
B737_2472	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B737_2472	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B737_2472	COG1703	isobutyryl-CoA mutase activity
B737_2473	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_2474	COG1309	transcriptional regulator
B737_2475	COG1960	acyl-CoA dehydrogenase activity
B737_2476	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B737_2479	COG0748	coenzyme F420 binding
B737_2480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_2482	COG1960	acyl-CoA dehydrogenase activity
B737_2483	COG1960	acyl-CoA dehydrogenase activity
B737_2484	COG2030	dehydratase
B737_2488	COG0196	riboflavin kinase activity
B737_2495	COG1960	acyl-CoA dehydrogenase activity
B737_2496	COG2267	carboxylic ester hydrolase activity
B737_2497	COG0346	lactoylglutathione lyase activity
B737_2498	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B737_2503	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B737_2507	COG0583	DNA-binding transcription factor activity
B737_2509	COG0446	pyridine nucleotide-disulphide oxidoreductase
B737_2521	COG1228	amidohydrolase
B737_2522	COG0596	Alpha beta hydrolase
B737_2523	COG0183	Belongs to the thiolase family
B737_2525	COG2124	cytochrome p450
B737_2527	COG1295	ribonuclease BN
B737_2533	COG2070	2-Nitropropane dioxygenase
B737_2536	COG2188	Transcriptional regulator
B737_2540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B737_2540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B737_2542	COG1490	D-aminoacyl-tRNA deacylase activity
B737_2543	COG2890	protein-(glutamine-N5) methyltransferase activity
B737_2544	COG1473	amidohydrolase
B737_2547	COG2313	pseudouridylate synthase activity
B737_2552	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B737_2555	COG4213	ABC transporter substrate-binding protein
B737_2557	COG4214	carbohydrate transport
B737_2562	COG0531	amino acid
B737_2569	COG0366	Alpha amylase catalytic
B737_2570	COG0366	Alpha amylase catalytic
B737_2572	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B737_2575	COG1940	carbohydrate kinase activity
B737_2576	COG0483	inositol monophosphate 1-phosphatase activity
B737_2580	COG0756	dUTP diphosphatase activity
B737_2586	COG0569	domain protein
B737_2587	COG0531	amino acid
B737_2588	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B737_2591	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B737_2593	COG1012	belongs to the aldehyde dehydrogenase family
B737_2594	COG0028	Belongs to the TPP enzyme family
B737_2598	COG0745	RESPONSE REGULATOR receiver
B737_2599	COG2205	protein histidine kinase activity
B737_2602	COG1024	Enoyl-CoA hydratase
B737_2602	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_2604	COG0183	Belongs to the thiolase family
B737_2611	COG0531	amino acid
B737_2614	COG2197	response regulator
B737_2616	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B737_2619	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_2621	COG3220	belongs to the UPF0276 family
B737_2624	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B737_2630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_2631	COG0539	negative regulation of cytoplasmic translation
B737_2633	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B737_2633	COG2508	Transcriptional regulator
B737_2634	COG1012	belongs to the aldehyde dehydrogenase family
B737_2635	COG0506	proline dehydrogenase activity
B737_2636	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B737_2638	COG3795	YCII-related domain
B737_2640	COG4941	Belongs to the sigma-70 factor family
B737_2642	COG1793	dna ligase
B737_2647	COG1302	Protein conserved in bacteria
B737_2649	COG1595	DNA-templated transcription, initiation
B737_2656	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B737_2657	COG0640	Transcriptional regulator
B737_2659	COG2326	polyphosphate kinase activity
B737_2662	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B737_2663	COG1993	acr, cog1993
B737_2664	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B737_2670	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B737_2670	COG1672	PFAM Archaeal ATPase
B737_2674	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B737_2679	COG2124	cytochrome p450
B737_2683	COG2084	Dehydrogenase
B737_2686	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B737_2688	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B737_2689	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B737_2690	COG1309	transcriptional regulator
B737_2691	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B737_2693	COG1073	alpha beta
B737_2695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B737_2697	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B737_2698	COG1263	PTS System
B737_2698	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B737_2700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B737_2700	COG1263	PTS System
B737_2701	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B737_2701	COG1263	PTS System
B737_2701	COG2190	(PTS) system
B737_2706	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B737_2707	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B737_2708	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B737_2709	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B737_2710	COG0346	lactoylglutathione lyase activity
B737_2713	COG0006	proline dipeptidase activity
B737_2714	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B737_2715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B737_2719	COG0540	Belongs to the ATCase OTCase family
B737_2722	COG0505	Belongs to the CarA family
B737_2723	COG0419	ATPase involved in DNA repair
B737_2726	COG0284	orotidine-5'-phosphate decarboxylase activity
B737_2728	COG0194	GDP metabolic process
B737_2729	COG1758	RNA polymerase activity
B737_2731	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B737_2736	COG0405	Gamma-glutamyltransferase
B737_2737	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B737_2742	COG2197	response regulator
B737_2743	COG4585	Histidine kinase
B737_2746	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B737_2746	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B737_2747	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B737_2751	COG0322	excinuclease ABC activity
B737_2752	COG1660	Displays ATPase and GTPase activities
B737_2754	COG1481	regulation of sporulation
B737_2755	COG0463	Glycosyl transferase, family 2
B737_2760	COG3250	beta-galactosidase activity
B737_2761	COG0408	coproporphyrinogen oxidase activity
B737_2768	COG1280	lysine exporter protein (LysE YggA)
B737_2771	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B737_2772	COG0126	phosphoglycerate kinase activity
B737_2773	COG0149	triose-phosphate isomerase activity
B737_2777	COG0363	glucosamine-6-phosphate deaminase activity
B737_2780	COG0166	Belongs to the GPI family
B737_2781	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B737_2783	COG0109	protoheme IX farnesyltransferase activity
B737_2804	COG0396	ATPase activity
B737_2807	COG2151	metal-sulfur cluster biosynthetic enzyme
B737_2809	COG1742	UPF0060 membrane protein
B737_2811	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B737_2813	COG4585	Histidine kinase
B737_2815	COG2226	methyltransferase
B737_2823	COG0457	Tetratricopeptide repeat
B737_2838	COG1132	(ABC) transporter
B737_2840	COG4821	SIS domain
B737_2842	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B737_2843	COG1316	TRANSCRIPTIONal
B737_2845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B737_2846	COG5001	Diguanylate cyclase
B737_2846	COG3300	MHYT domain
B737_2849	COG1051	belongs to the nudix hydrolase family
B737_2851	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B737_2851	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B737_2853	COG1024	Enoyl-CoA hydratase
B737_2858	COG1960	acyl-CoA dehydrogenase activity
B737_2859	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B737_2862	COG1028	Short-chain dehydrogenase reductase Sdr
B737_2867	COG3469	chitinase activity
B737_2875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B737_2877	COG3693	PFAM glycoside hydrolase, family 10
B737_2881	COG1309	transcriptional regulator
B737_2882	COG0789	Transcriptional regulator
B737_2885	COG4249	Peptidase C14 caspase catalytic subunit p20
B737_2885	COG2319	Wd-40 repeat
B737_2888	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_2901	COG2197	response regulator
B737_2914	COG0300	oxidoreductase activity
B737_2916	COG1846	Transcriptional regulator
B737_2919	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B737_2922	COG1595	DNA-templated transcription, initiation
B737_2926	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B737_2927	COG1799	cell septum assembly
B737_2929	COG3599	regulation of cell shape
B737_2931	COG0640	Transcriptional regulator
B737_2932	COG0477	Major facilitator Superfamily
B737_2933	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B737_2935	COG0640	Transcriptional regulator
B737_2936	COG3263	regulation of cellular component size
B737_2937	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B737_2939	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B737_2944	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_2946	COG0248	Ppx GppA phosphatase
B737_2953	COG1940	carbohydrate kinase activity
B737_2953	COG1846	Transcriptional regulator
B737_2956	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B737_2961	COG2010	Cytochrome c
B737_2961	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B737_2966	COG1309	transcriptional regulator
B737_2967	COG4221	oxidoreductase activity
B737_2968	COG0667	Aldo Keto reductase
B737_2969	COG0542	response to heat
B737_2970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B737_2973	COG0514	ATP-dependent DNA helicase (RecQ)
B737_2975	COG1028	Short-chain dehydrogenase reductase Sdr
B737_2982	COG2205	protein histidine kinase activity
B737_2983	COG0745	RESPONSE REGULATOR receiver
B737_2986	COG0076	glutamate decarboxylase activity
B737_2996	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B737_2998	COG1131	(ABC) transporter
B737_3002	COG0604	alcohol dehydrogenase
B737_3004	COG2764	glyoxalase bleomycin resistance protein dioxygenase
B737_3006	COG4585	Histidine kinase
B737_3008	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B737_3009	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B737_3010	COG2080	2 iron, 2 sulfur cluster binding
B737_3015	COG2188	Transcriptional regulator
B737_3017	COG1063	alcohol dehydrogenase
B737_3020	COG2172	sigma factor antagonist activity
B737_3021	COG1366	Belongs to the anti-sigma-factor antagonist family
B737_3022	COG1366	Belongs to the anti-sigma-factor antagonist family
B737_3027	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3028	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B737_3030	COG3546	catalase activity
B737_3032	COG0702	epimerase
B737_3033	COG1733	regulation of RNA biosynthetic process
B737_3037	COG1609	Transcriptional regulator
B737_3039	COG1175	transmembrane transport
B737_3040	COG0395	ABC-type sugar transport system, permease component
B737_3044	COG0667	Aldo Keto reductase
B737_3045	COG0667	Aldo Keto reductase
B737_3048	COG2378	regulation of single-species biofilm formation
B737_3050	COG1691	(AIR) carboxylase
B737_3051	COG3875	lactate racemase activity
B737_3052	COG3618	amidohydrolase
B737_3053	COG0179	Fumarylacetoacetate (FAA) hydrolase
B737_3054	COG4948	Mandelate Racemase Muconate Lactonizing
B737_3057	COG1129	ABC transporter
B737_3065	COG1609	Transcriptional regulator
B737_3066	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3070	COG3251	PFAM MbtH domain protein
B737_3074	COG2124	cytochrome p450
B737_3078	COG0604	alcohol dehydrogenase
B737_3082	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B737_3093	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3097	COG3250	beta-galactosidase activity
B737_3099	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3100	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3102	COG1309	transcriptional regulator
B737_3105	COG1960	acyl-CoA dehydrogenase activity
B737_3106	COG1960	acyl-CoA dehydrogenase activity
B737_3111	COG4948	Mandelate Racemase Muconate Lactonizing
B737_3114	COG0395	ABC-type sugar transport system, permease component
B737_3115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B737_3116	COG0515	serine threonine protein kinase
B737_3123	COG2814	Major facilitator Superfamily
B737_3125	COG5002	protein histidine kinase activity
B737_3128	COG1131	(ABC) transporter
B737_3132	COG1309	transcriptional regulator
B737_3137	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B737_3138	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_3140	COG1595	DNA-templated transcription, initiation
B737_3144	COG0596	Alpha beta hydrolase
B737_3146	COG0477	Major facilitator Superfamily
B737_3155	COG0366	Alpha amylase catalytic
B737_3159	COG1175	transmembrane transport
B737_3162	COG1349	DNA-binding transcription factor activity
B737_3164	COG1609	Transcriptional regulator
B737_3165	COG2815	serine threonine protein kinase
B737_3165	COG0515	serine threonine protein kinase
B737_3166	COG2815	serine threonine protein kinase
B737_3166	COG0515	serine threonine protein kinase
B737_3169	COG0437	4 iron, 4 sulfur cluster binding
B737_3171	COG2271	Major facilitator Superfamily
B737_3174	COG2318	DinB family
B737_3180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B737_3182	COG0583	DNA-binding transcription factor activity
B737_3183	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_3185	COG1053	succinate dehydrogenase
B737_3186	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B737_3193	COG3511	phospholipase C
B737_3200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B737_3202	COG3938	Belongs to the proline racemase family
B737_3203	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_3203	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_3204	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_3206	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B737_3207	COG0395	ABC-type sugar transport system, permease component
B737_3208	COG1175	transmembrane transport
B737_3218	COG0628	permease
B737_3219	COG3507	Belongs to the glycosyl hydrolase 43 family
B737_3220	COG3285	dna ligase
B737_3220	COG1793	dna ligase
B737_3223	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B737_3224	COG2226	methyltransferase
B737_3231	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_3232	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B737_3233	COG1024	Enoyl-CoA hydratase
B737_3236	COG1012	belongs to the aldehyde dehydrogenase family
B737_3250	COG3507	Belongs to the glycosyl hydrolase 43 family
B737_3264	COG1309	transcriptional regulator
B737_3265	COG1595	DNA-templated transcription, initiation
B737_3268	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3269	COG0028	Belongs to the TPP enzyme family
B737_3273	COG2018	Roadblock/LC7 domain
B737_3277	COG2188	Transcriptional regulator
B737_3278	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B737_3279	COG0395	ABC-type sugar transport system, permease component
B737_3280	COG1175	transmembrane transport
B737_3283	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B737_3290	COG0745	RESPONSE REGULATOR receiver
B737_3290	COG3706	GGDEF domain
B737_3291	COG1609	Transcriptional regulator
B737_3297	COG3591	Belongs to the peptidase S1B family
B737_3302	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B737_3307	COG2267	carboxylic ester hydrolase activity
B737_3315	COG2357	RelA SpoT domain protein
B737_3319	COG1280	lysine exporter protein (LysE YggA)
B737_3320	COG0484	heat shock protein binding
B737_3321	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B737_3326	COG2409	Drug exporters of the RND superfamily
B737_3328	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B737_3338	COG1024	Enoyl-CoA hydratase
B737_3342	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_3343	COG0183	Belongs to the thiolase family
B737_3345	COG1960	acyl-CoA dehydrogenase activity
B737_3346	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3347	COG1024	Enoyl-CoA hydratase
B737_3348	COG1960	acyl-CoA dehydrogenase activity
B737_3349	COG1960	acyl-CoA dehydrogenase activity
B737_3351	COG1960	acyl-CoA dehydrogenase activity
B737_3353	COG1802	Transcriptional regulator
B737_3354	COG1864	DNA RNA non-specific endonuclease
B737_3354	COG3591	Belongs to the peptidase S1B family
B737_3357	COG1063	alcohol dehydrogenase
B737_3358	COG2267	carboxylic ester hydrolase activity
B737_3362	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B737_3363	COG1309	transcriptional regulator
B737_3367	COG3345	alpha-galactosidase
B737_3369	COG1175	transmembrane transport
B737_3370	COG0395	ABC-type sugar transport system, permease component
B737_3377	COG0477	Major facilitator Superfamily
B737_3379	COG1940	carbohydrate kinase activity
B737_3380	COG0531	amino acid
B737_3381	COG3250	beta-galactosidase activity
B737_3382	COG1940	carbohydrate kinase activity
B737_3384	COG1609	Transcriptional regulator
B737_3387	COG2124	cytochrome p450
B737_3395	COG1846	Transcriptional regulator
B737_3397	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_3406	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3412	COG0702	epimerase
B737_3417	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B737_3420	COG4948	Mandelate Racemase Muconate Lactonizing
B737_3424	COG0601	transmembrane transport
B737_3425	COG0444	Belongs to the ABC transporter superfamily
B737_3426	COG4608	Belongs to the ABC transporter superfamily
B737_3428	COG0477	Major facilitator Superfamily
B737_3433	COG0477	Major facilitator Superfamily
B737_3435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B737_3438	COG0604	alcohol dehydrogenase
B737_3438	COG3321	synthase
B737_3439	COG3507	Belongs to the glycosyl hydrolase 43 family
B737_3442	COG1231	oxidoreductase activity
B737_3444	COG0235	Class ii aldolase
B737_3444	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B737_3447	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3448	COG0701	Predicted permease
B737_3453	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3455	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3457	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3459	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B737_3466	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B737_3472	COG0501	Belongs to the peptidase M48B family
B737_3479	COG0475	glutathione-regulated potassium exporter activity
B737_3479	COG0569	domain protein
B737_3486	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B737_3487	COG4279	zinc finger
B737_3495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_3500	COG0069	glutamate synthase activity
B737_3501	COG0745	RESPONSE REGULATOR receiver
B737_3502	COG5002	protein histidine kinase activity
B737_3505	COG0577	efflux transmembrane transporter activity
B737_3505	COG1136	(ABC) transporter
B737_3506	COG0577	efflux transmembrane transporter activity
B737_3506	COG1136	(ABC) transporter
B737_3509	COG2814	Major facilitator Superfamily
B737_3510	COG0596	Alpha beta hydrolase
B737_3512	COG4585	Histidine kinase
B737_3518	COG4585	Histidine kinase
B737_3526	COG4221	oxidoreductase activity
B737_3527	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B737_3541	COG0745	RESPONSE REGULATOR receiver
B737_3542	COG2205	protein histidine kinase activity
B737_3546	COG0726	polysaccharide deacetylase
B737_3568	COG4221	oxidoreductase activity
B737_3569	COG4249	Peptidase C14 caspase catalytic subunit p20
B737_3569	COG2319	Wd-40 repeat
B737_3582	COG2197	response regulator
B737_3583	COG0736	holo-[acyl-carrier-protein] synthase activity
B737_3587	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B737_3598	COG1834	amidinotransferase
B737_3600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B737_3601	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B737_3602	COG2080	2 iron, 2 sulfur cluster binding
B737_3604	COG3345	alpha-galactosidase
B737_3611	COG1309	transcriptional regulator
B737_3617	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3618	COG0583	DNA-binding transcription factor activity
B737_3632	COG0583	DNA-binding transcription factor activity
B737_3649	COG2205	protein histidine kinase activity
B737_3655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_3663	COG1522	sequence-specific DNA binding
B737_3676	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B737_3678	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B737_3679	COG2080	2 iron, 2 sulfur cluster binding
B737_3684	COG0631	protein serine/threonine phosphatase activity
B737_3693	COG3509	depolymerase
B737_3697	COG0601	transmembrane transport
B737_3699	COG4608	Belongs to the ABC transporter superfamily
B737_3701	COG1609	Transcriptional regulator
B737_3702	COG4124	Belongs to the glycosyl hydrolase 26 family
B737_3704	COG1846	Transcriptional regulator
B737_3704	COG1940	carbohydrate kinase activity
B737_3706	COG1960	acyl-CoA dehydrogenase activity
B737_3707	COG2207	Transcriptional regulator
B737_3721	COG0745	RESPONSE REGULATOR receiver
B737_3722	COG2205	protein histidine kinase activity
B737_3723	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B737_3723	COG2755	lipolytic protein G-D-S-L family
B737_3729	COG2267	carboxylic ester hydrolase activity
B737_3730	COG2226	methyltransferase
B737_3732	COG0640	Transcriptional regulator
B737_3740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B737_3741	COG0375	protein maturation
B737_3743	COG0409	Hydrogenase expression formation protein
B737_3752	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B737_3754	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B737_3761	COG3629	intracellular signal transduction
B737_3761	COG3903	Transcriptional regulator
B737_3762	COG0596	Alpha beta hydrolase
B737_3763	COG1024	Enoyl-CoA hydratase
B737_3763	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_3764	COG1733	regulation of RNA biosynthetic process
B737_3770	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3771	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_3772	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3773	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3779	COG0411	ABC transporter
B737_3781	COG1024	Enoyl-CoA hydratase
B737_3782	COG1960	acyl-CoA dehydrogenase activity
B737_3783	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3784	COG1946	Acyl-CoA thioesterase
B737_3786	COG1024	Enoyl-CoA hydratase
B737_3787	COG1960	acyl-CoA dehydrogenase activity
B737_3788	COG1012	belongs to the aldehyde dehydrogenase family
B737_3790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_3791	COG0183	Belongs to the thiolase family
B737_3799	COG1946	Acyl-CoA thioesterase
B737_3803	COG1960	acyl-CoA dehydrogenase activity
B737_3807	COG0183	Belongs to the thiolase family
B737_3810	COG0183	Belongs to the thiolase family
B737_3811	COG1024	Enoyl-CoA hydratase
B737_3814	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3817	COG1024	Enoyl-CoA hydratase
B737_3819	COG1960	acyl-CoA dehydrogenase activity
B737_3820	COG1960	acyl-CoA dehydrogenase activity
B737_3821	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3826	COG1960	acyl-CoA dehydrogenase activity
B737_3829	COG1012	belongs to the aldehyde dehydrogenase family
B737_3830	COG1960	acyl-CoA dehydrogenase activity
B737_3831	COG1960	acyl-CoA dehydrogenase activity
B737_3832	COG1024	Enoyl-CoA hydratase
B737_3833	COG2188	Transcriptional regulator
B737_3834	COG0300	oxidoreductase activity
B737_3835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B737_3841	COG1309	transcriptional regulator
B737_3843	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B737_3844	COG3629	intracellular signal transduction
B737_3844	COG3903	Transcriptional regulator
B737_3848	COG1017	nitric oxide dioxygenase activity
B737_3848	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B737_3849	COG1846	Transcriptional regulator
B737_3849	COG1940	carbohydrate kinase activity
B737_3851	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B737_3853	COG0531	amino acid
B737_3854	COG3387	PFAM Glycoside hydrolase 15-related
B737_3855	COG2814	Major facilitator Superfamily
B737_3857	COG2197	response regulator
B737_3864	COG0628	permease
B737_3867	COG1486	melibiose metabolic process
B737_3868	COG0395	ABC-type sugar transport system, permease component
B737_3872	COG1349	DNA-binding transcription factor activity
B737_3873	COG2222	sugar isomerase
B737_3876	COG1105	Belongs to the carbohydrate kinase PfkB family
B737_3889	COG0596	Alpha beta hydrolase
B737_3891	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B737_3891	COG1024	Enoyl-CoA hydratase
B737_3893	COG3903	Transcriptional regulator
B737_3893	COG3629	intracellular signal transduction
B737_3894	COG1132	(ABC) transporter
B737_3899	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3903	COG4221	oxidoreductase activity
B737_3904	COG4948	Mandelate Racemase Muconate Lactonizing
B737_3905	COG0395	ABC-type sugar transport system, permease component
B737_3906	COG3833	ABC-type maltose transport systems, permease component
B737_3913	COG2124	cytochrome p450
B737_3914	COG2175	clavaminate synthase activity
B737_3915	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3915	COG3321	synthase
B737_3915	COG4221	oxidoreductase activity
B737_3915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_3916	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_3917	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3926	COG1940	carbohydrate kinase activity
B737_3927	COG1940	carbohydrate kinase activity
B737_3927	COG1846	Transcriptional regulator
B737_3928	COG1129	ABC transporter
B737_3929	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_3931	COG0673	inositol 2-dehydrogenase activity
B737_3933	COG0604	alcohol dehydrogenase
B737_3948	COG1064	alcohol dehydrogenase
B737_3949	COG1309	transcriptional regulator
B737_3950	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3953	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B737_3954	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_3958	COG2508	Transcriptional regulator
B737_3959	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B737_3961	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B737_3962	COG0463	Glycosyl transferase, family 2
B737_3964	COG0318	PFAM AMP-dependent synthetase and ligase
B737_3966	COG3629	intracellular signal transduction
B737_3967	COG0583	DNA-binding transcription factor activity
B737_3969	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3970	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3972	COG1846	Transcriptional regulator
B737_3973	COG3903	Transcriptional regulator
B737_3973	COG3629	intracellular signal transduction
B737_3974	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B737_3977	COG2197	response regulator
B737_3979	COG0577	efflux transmembrane transporter activity
B737_3979	COG1136	(ABC) transporter
B737_3985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B737_3991	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B737_3994	COG1028	Short-chain dehydrogenase reductase Sdr
B737_3996	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B737_3997	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B737_3998	COG3903	Transcriptional regulator
B737_3998	COG3629	intracellular signal transduction
B737_3999	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B737_4003	COG3509	depolymerase
B737_4004	COG2205	protein histidine kinase activity
B737_4005	COG0745	RESPONSE REGULATOR receiver
B737_4006	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B737_4008	COG0583	DNA-binding transcription factor activity
B737_4012	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_4019	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B737_4037	COG0395	ABC-type sugar transport system, permease component
B737_4040	COG1609	Transcriptional regulator
B737_4046	COG0653	protein targeting
B737_4055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_4057	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B737_4061	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B737_4062	COG1012	belongs to the aldehyde dehydrogenase family
B737_4063	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B737_4070	COG3661	Belongs to the glycosyl hydrolase 67 family
B737_4073	COG1028	Short-chain dehydrogenase reductase Sdr
B737_4082	COG2201	protein-glutamate methylesterase activity
B737_4083	COG2201	protein-glutamate methylesterase activity
B737_4087	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B737_4096	COG0477	Major facilitator Superfamily
B737_4099	COG2318	DinB family
B737_4100	COG1793	dna ligase
B737_4106	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B737_4108	COG2814	Major facilitator Superfamily
B737_4110	COG2855	membrane
B737_4111	COG0583	DNA-binding transcription factor activity
B737_4118	COG0439	Biotin carboxylase
B737_4126	COG0477	Major facilitator Superfamily
B737_4131	COG0318	PFAM AMP-dependent synthetase and ligase
B737_4135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B737_4140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B737_4147	COG1793	dna ligase
B737_4147	COG3285	dna ligase
B737_4152	COG2267	carboxylic ester hydrolase activity
B737_4160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B737_4162	COG3634	alkyl hydroperoxide reductase activity
B737_4166	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B737_4178	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B737_4181	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B737_4183	COG2890	protein-(glutamine-N5) methyltransferase activity
B737_4187	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B737_4188	COG2124	cytochrome p450
B737_4190	COG2201	protein-glutamate methylesterase activity
B737_4193	COG2815	serine threonine protein kinase
B737_4193	COG0515	serine threonine protein kinase
B737_4195	COG0326	Molecular chaperone. Has ATPase activity
B737_4197	COG3794	PFAM blue (type 1) copper domain protein
B737_4210	COG1028	Short-chain dehydrogenase reductase Sdr
B737_4213	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B737_4218	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B737_4220	COG0300	oxidoreductase activity
B737_4221	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B737_4221	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B737_4222	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B737_4223	COG2192	nodulation
B737_4224	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B737_4227	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B737_4227	COG0463	Glycosyl transferase, family 2
B737_4228	COG0297	glycogen (starch) synthase activity
B737_4237	COG1959	2 iron, 2 sulfur cluster binding
B737_4237	COG1295	ribonuclease BN
B737_4242	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B737_4242	COG0723	plastoquinol--plastocyanin reductase activity
B737_4243	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B737_4244	COG2890	protein-(glutamine-N5) methyltransferase activity
B737_4247	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B737_4249	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B737_4251	COG1982	Orn Lys Arg decarboxylase major
B737_4255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B737_4260	COG0596	Alpha beta hydrolase
B737_4265	COG3835	regulator
B737_4270	COG3284	Transcriptional regulator
B737_4279	COG0459	protein refolding
B737_4283	COG0596	Alpha beta hydrolase
B737_4285	COG1028	Short-chain dehydrogenase reductase Sdr
B737_4286	COG0435	Glutathione S-transferase
B737_4288	COG2353	YceI-like domain
B737_4289	COG1309	transcriptional regulator
B737_4292	COG0395	ABC-type sugar transport system, permease component
B737_4295	COG1609	Transcriptional regulator
B737_4296	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_4298	COG2124	cytochrome p450
B737_4300	COG1716	ATPase activity
B737_4300	COG5001	Diguanylate cyclase
B737_4303	COG2181	nitrate reductase activity
B737_4303	COG0247	lactate metabolic process
B737_4304	COG1716	ATPase activity
B737_4305	COG0477	Major facilitator Superfamily
B737_4308	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B737_4313	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_4315	COG4991	sh3 domain protein
B737_4330	COG0302	gtp cyclohydrolase
B737_4333	COG1609	Transcriptional regulator
B737_4337	COG1028	Short-chain dehydrogenase reductase Sdr
B737_4340	COG1686	Belongs to the peptidase S11 family
B737_4342	COG1609	Transcriptional regulator
B737_4343	COG1879	ABC-type sugar transport system periplasmic component
B737_4345	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_4346	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_4350	COG2160	L-arabinose isomerase activity
B737_4352	COG1129	ABC transporter
B737_4353	COG4214	carbohydrate transport
B737_4355	COG1609	Transcriptional regulator
B737_4357	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B737_4358	COG1414	Transcriptional regulator
B737_4360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B737_4361	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B737_4363	COG0137	argininosuccinate synthase activity
B737_4372	COG0277	FAD linked oxidase domain protein
B737_4373	COG1609	Transcriptional regulator
B737_4375	COG1653	transport
B737_4376	COG1175	transmembrane transport
B737_4377	COG0395	ABC-type sugar transport system, permease component
B737_4379	COG0673	inositol 2-dehydrogenase activity
B737_4380	COG0673	inositol 2-dehydrogenase activity
B737_4382	COG3866	Pectate lyase
B737_4387	COG3629	intracellular signal transduction
B737_4387	COG3903	Transcriptional regulator
B737_4391	COG0589	response to stress
B737_4392	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B737_4404	COG1090	epimerase
B737_4409	COG0297	glycogen (starch) synthase activity
B737_4414	COG3250	beta-galactosidase activity
B737_4417	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B737_4426	COG0477	Major facilitator Superfamily
B737_4427	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_4427	COG3321	synthase
B737_4428	COG0318	PFAM AMP-dependent synthetase and ligase
B737_4431	COG0300	oxidoreductase activity
B737_4432	COG1819	glycosyl
B737_4435	COG3285	dna ligase
B737_4435	COG1793	dna ligase
B737_4436	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B737_4439	COG2267	carboxylic ester hydrolase activity
B737_4442	COG3903	Transcriptional regulator
B737_4442	COG3629	intracellular signal transduction
B737_4443	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B737_4445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B737_4445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B737_4445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B737_4448	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B737_4452	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_4453	COG1609	Transcriptional regulator
B737_4456	COG0395	ABC-type sugar transport system, permease component
B737_4458	COG1609	Transcriptional regulator
B737_4462	COG1278	Cold shock
B737_4463	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B737_4473	COG0387	Pfam Sodium calcium exchanger
B737_4474	COG0583	DNA-binding transcription factor activity
B737_4475	COG0028	Belongs to the TPP enzyme family
B737_4483	COG1609	Transcriptional regulator
B737_4484	COG1129	ABC transporter
B737_4485	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_4486	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_4488	COG3254	rhamnose metabolic process
B737_4490	COG1028	Short-chain dehydrogenase reductase Sdr
B737_4490	COG3347	Dehydrogenase
B737_4492	COG1070	Carbohydrate kinase
B737_4493	COG2197	response regulator
B737_4494	COG4585	Histidine kinase
B737_4497	COG3250	beta-galactosidase activity
B737_4508	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B737_4509	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B737_4513	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B737_4515	COG0045	succinate-CoA ligase (ADP-forming) activity
B737_4517	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_4518	COG0045	succinate-CoA ligase (ADP-forming) activity
B737_4518	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B737_4518	COG1042	CoA-binding domain protein
B737_4519	COG2223	nitrite transmembrane transporter activity
B737_4520	COG1802	Transcriptional regulator
B737_4521	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B737_4522	COG3383	formate dehydrogenase (NAD+) activity
B737_4523	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B737_4524	COG1034	ATP synthesis coupled electron transport
B737_4525	COG3622	Belongs to the hyi family
B737_4526	COG2084	Dehydrogenase
B737_4527	COG3960	tartronate-semialdehyde synthase activity
B737_4530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B737_4531	COG0590	tRNA wobble adenosine to inosine editing
B737_4532	COG2252	PERMEase
B737_4534	COG1929	Belongs to the glycerate kinase type-1 family
B737_4545	COG2066	Belongs to the glutaminase family
B737_4548	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B737_4551	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B737_4552	COG0596	Alpha beta hydrolase
B737_4554	COG1028	Short-chain dehydrogenase reductase Sdr
B737_4557	COG3285	dna ligase
B737_4557	COG1793	dna ligase
B737_4558	COG0183	Belongs to the thiolase family
B737_4559	COG1733	regulation of RNA biosynthetic process
B737_4566	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_4567	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_4568	COG1609	Transcriptional regulator
B737_4570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B737_4571	COG2267	carboxylic ester hydrolase activity
B737_4578	COG0667	Aldo Keto reductase
B737_4579	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_4580	COG1968	undecaprenyl-diphosphatase activity
B737_4582	COG0339	signal peptide processing
B737_4583	COG0740	serine-type endopeptidase activity
B737_4584	COG0039	L-malate dehydrogenase activity
B737_4591	COG3537	Alpha-1,2-mannosidase
B737_4599	COG0747	negative chemotaxis
B737_4600	COG0601	transmembrane transport
B737_4602	COG4172	Belongs to the ABC transporter superfamily
B737_4605	COG1619	proteins homologs of microcin C7 resistance protein MccF
B737_4606	COG4946	Tricorn protease homolog
B737_4606	COG0823	Involved in the tonB-independent uptake of proteins
B737_4606	COG1506	peptidase
B737_4618	COG0477	Major facilitator Superfamily
B737_4622	COG0640	Transcriptional regulator
B737_4631	COG4941	Belongs to the sigma-70 factor family
B737_4644	COG4941	Belongs to the sigma-70 factor family
B737_4647	COG2124	cytochrome p450
B737_4650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B737_4653	COG1309	transcriptional regulator
B737_4654	COG1960	acyl-CoA dehydrogenase activity
B737_4656	COG1309	transcriptional regulator
B737_4658	COG1396	sequence-specific DNA binding
B737_4661	COG0640	Transcriptional regulator
B737_4663	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B737_4668	COG1435	thymidine kinase activity
B737_4670	COG0494	nUDIX hydrolase
B737_4671	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B737_4673	COG0463	Glycosyl transferase, family 2
B737_4675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B737_4679	COG4977	sequence-specific DNA binding
B737_4680	COG1733	regulation of RNA biosynthetic process
B737_4684	COG3903	Transcriptional regulator
B737_4684	COG3629	intracellular signal transduction
B737_4691	COG4865	methylaspartate mutase activity
B737_4692	COG0017	Asparaginyl-tRNA synthetase
B737_4693	COG0069	glutamate synthase activity
B737_4696	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B737_4706	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_4711	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_4716	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_4728	COG4948	Mandelate Racemase Muconate Lactonizing
B737_4729	COG2186	Transcriptional regulator
B737_4730	COG0395	ABC-type sugar transport system, permease component
B737_4731	COG1175	transmembrane transport
B737_4732	COG3293	Transposase
B737_4736	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B737_4738	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B737_4739	COG4865	methylaspartate mutase activity
B737_4741	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_4750	COG0789	Transcriptional regulator
B737_4760	COG2124	cytochrome p450
B737_4767	COG2197	response regulator
B737_4768	COG2197	response regulator
B737_4770	COG0823	Involved in the tonB-independent uptake of proteins
B737_4791	COG0402	S-adenosylhomocysteine deaminase activity
B737_4792	COG1414	Transcriptional regulator
B737_4793	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_4795	COG3485	protocatechuate 3,4-dioxygenase
B737_4799	COG3979	chitinase
B737_4801	COG1136	(ABC) transporter
B737_4805	COG4221	oxidoreductase activity
B737_4807	COG0583	DNA-binding transcription factor activity
B737_4808	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B737_4817	COG4552	Acetyltransferase involved in intracellular survival and related
B737_4820	COG1597	lipid kinase activity
B737_4823	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B737_4825	COG2378	regulation of single-species biofilm formation
B737_4827	COG1733	regulation of RNA biosynthetic process
B737_4830	COG4221	oxidoreductase activity
B737_4831	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B737_4834	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B737_4835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B737_4842	COG0640	Transcriptional regulator
B737_4845	COG0697	spore germination
B737_4846	COG1222	aaa ATPase
B737_4851	COG0517	IMP dehydrogenase activity
B737_4851	COG1994	Peptidase M50
B737_4854	COG1192	Involved in chromosome partitioning
B737_4855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B737_4856	COG0140	phosphoribosyl-ATP diphosphatase activity
B737_4859	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B737_4860	COG1410	methionine synthase
B737_4860	COG0646	methionine synthase
B737_4866	COG2814	Major facilitator Superfamily
B737_4870	COG0488	(ABC) transporter
B737_4871	COG0215	cysteine-tRNA ligase activity
B737_4872	COG0789	Transcriptional regulator
B737_4873	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B737_4874	COG4867	von Willebrand factor, type A
B737_4881	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B737_4883	COG0477	Major facilitator Superfamily
B737_4884	COG0745	RESPONSE REGULATOR receiver
B737_4885	COG2205	protein histidine kinase activity
B737_4888	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B737_4890	COG2304	oxidoreductase activity
B737_4892	COG0714	Associated with various cellular activities
B737_4893	COG0746	molybdenum cofactor guanylyltransferase activity
B737_4894	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B737_4895	COG0791	NLP P60 protein
B737_4895	COG3883	PFAM NLP P60 protein
B737_4896	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B737_4897	COG1285	pathogenesis
B737_4899	COG1309	transcriptional regulator
B737_4902	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B737_4904	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B737_4905	COG3572	ergothioneine biosynthetic process
B737_4907	COG2267	carboxylic ester hydrolase activity
B737_4908	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B737_4913	COG1309	transcriptional regulator
B737_4921	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B737_4924	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B737_4924	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B737_4928	COG0789	Transcriptional regulator
B737_4931	COG1716	ATPase activity
B737_4937	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B737_4938	COG1024	Enoyl-CoA hydratase
B737_4939	COG2267	carboxylic ester hydrolase activity
B737_4940	COG1648	precorrin-2 dehydrogenase activity
B737_4940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B737_4943	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B737_4944	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B737_4945	COG0254	rRNA binding
B737_4953	COG2211	Major facilitator Superfamily
B737_4954	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_4960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_4963	COG1116	anion transmembrane transporter activity
B737_4964	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B737_4965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B737_4966	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B737_4970	COG1132	(ABC) transporter
B737_4973	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B737_4975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B737_4976	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B737_4977	COG1120	ATPase activity
B737_4978	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B737_4986	COG0488	(ABC) transporter
B737_4994	COG3293	Transposase
B737_5007	COG3250	beta-galactosidase activity
B737_5011	COG4948	Mandelate Racemase Muconate Lactonizing
B737_5013	COG4948	Mandelate Racemase Muconate Lactonizing
B737_5014	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B737_5016	COG1116	anion transmembrane transporter activity
B737_5017	COG2205	protein histidine kinase activity
B737_5018	COG0745	RESPONSE REGULATOR receiver
B737_5024	COG1846	Transcriptional regulator
B737_5025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B737_5027	COG0028	Belongs to the TPP enzyme family
B737_5028	COG1073	alpha beta
B737_5029	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5030	COG0179	Fumarylacetoacetate (FAA) hydrolase
B737_5032	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_5036	COG1129	ABC transporter
B737_5037	COG1172	Belongs to the binding-protein-dependent transport system permease family
B737_5040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B737_5046	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B737_5047	COG0463	Glycosyl transferase, family 2
B737_5054	COG4221	oxidoreductase activity
B737_5057	COG1921	L-seryl-tRNASec selenium transferase activity
B737_5058	COG0709	Synthesizes selenophosphate from selenide and ATP
B737_5064	COG2249	NAD(P)H dehydrogenase (quinone) activity
B737_5065	COG2367	Beta-lactamase
B737_5068	COG2267	carboxylic ester hydrolase activity
B737_5075	COG0596	Alpha beta hydrolase
B737_5077	COG1309	transcriptional regulator
B737_5085	COG2409	Drug exporters of the RND superfamily
B737_5089	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B737_5090	COG0019	diaminopimelate decarboxylase activity
B737_5099	COG2201	protein-glutamate methylesterase activity
B737_5100	COG4585	Histidine kinase
B737_5102	COG2197	response regulator
B737_5105	COG1324	tolerance protein
B737_5116	COG2814	Major facilitator Superfamily
B737_5123	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B737_5124	COG0667	Aldo Keto reductase
B737_5129	COG5297	Belongs to the glycosyl hydrolase family 6
B737_5130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B737_5131	COG4733	cellulase activity
B737_5131	COG5297	Belongs to the glycosyl hydrolase family 6
B737_5135	COG0395	ABC-type sugar transport system, permease component
B737_5137	COG0129	dihydroxy-acid dehydratase activity
B737_5140	COG1573	uracil-dna glycosylase
B737_5141	COG1793	dna ligase
B737_5141	COG3285	dna ligase
B737_5143	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B737_5162	COG0583	DNA-binding transcription factor activity
B737_5164	COG0019	diaminopimelate decarboxylase activity
B737_5168	COG0477	Major facilitator Superfamily
B737_5170	COG0456	acetyltransferase
B737_5172	COG4104	PAAR repeat-containing protein
B737_5172	COG3209	COG3209 Rhs family protein
B737_5193	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B737_5199	COG0456	acetyltransferase
B737_5200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B737_5203	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B737_5207	COG2018	Roadblock/LC7 domain
B737_5208	COG2205	protein histidine kinase activity
B737_5215	COG3629	intracellular signal transduction
B737_5215	COG3903	Transcriptional regulator
B737_5220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B737_5223	COG1024	Enoyl-CoA hydratase
B737_5223	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_5230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B737_5231	COG0402	S-adenosylhomocysteine deaminase activity
B737_5232	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B737_5233	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B737_5234	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B737_5235	COG1862	Preprotein translocase
B737_5236	COG2255	four-way junction helicase activity
B737_5237	COG0632	four-way junction helicase activity
B737_5238	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B737_5241	COG0217	transcriptional regulatory protein
B737_5242	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B737_5245	COG1396	sequence-specific DNA binding
B737_5246	COG0644	oxidoreductase
B737_5247	COG1960	acyl-CoA dehydrogenase activity
B737_5251	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B737_5253	COG0277	FAD linked oxidase domain protein
B737_5255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B737_5255	COG3608	succinylglutamate desuccinylase aspartoacylase
B737_5259	COG0438	transferase activity, transferring glycosyl groups
B737_5264	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B737_5265	COG0778	Nitroreductase
B737_5269	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B737_5270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B737_5271	COG0701	Predicted permease
B737_5274	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5276	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B737_5279	COG1473	amidohydrolase
B737_5282	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B737_5286	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_5288	COG0318	PFAM AMP-dependent synthetase and ligase
B737_5301	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B737_5302	COG0395	ABC-type sugar transport system, permease component
B737_5303	COG1175	transmembrane transport
B737_5306	COG2072	flavoprotein involved in K transport
B737_5309	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5318	COG2211	Major facilitator Superfamily
B737_5319	COG1802	Transcriptional regulator
B737_5327	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B737_5335	COG3483	tryptophan 2,3-dioxygenase activity
B737_5338	COG2197	response regulator
B737_5339	COG4585	Histidine kinase
B737_5341	COG1131	(ABC) transporter
B737_5343	COG3510	cephalosporin hydroxylase
B737_5344	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_5346	COG1819	glycosyl
B737_5348	COG1819	glycosyl
B737_5356	COG3629	intracellular signal transduction
B737_5357	COG1819	glycosyl
B737_5358	COG3848	Pyruvate phosphate dikinase
B737_5358	COG0574	Belongs to the PEP-utilizing enzyme family
B737_5361	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5365	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5367	COG2867	negative regulation of translational initiation
B737_5368	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B737_5369	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B737_5370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B737_5371	COG0662	Cupin 2, conserved barrel domain protein
B737_5374	COG3104	oligopeptide transport
B737_5375	COG2345	Transcriptional regulator
B737_5376	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_5380	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5389	COG3209	COG3209 Rhs family protein
B737_5395	COG0659	secondary active sulfate transmembrane transporter activity
B737_5397	COG0589	response to stress
B737_5401	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B737_5404	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B737_5405	COG1042	CoA-binding domain protein
B737_5405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B737_5405	COG0045	succinate-CoA ligase (ADP-forming) activity
B737_5409	COG1271	oxidase subunit
B737_5410	COG1294	oxidase, subunit
B737_5411	COG4988	ABC transporter
B737_5412	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B737_5414	COG2239	Acts as a magnesium transporter
B737_5420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B737_5424	COG4585	Histidine kinase
B737_5425	COG2197	response regulator
B737_5429	COG4585	Histidine kinase
B737_5430	COG2197	response regulator
B737_5441	COG2197	response regulator
B737_5448	COG0681	Belongs to the peptidase S26 family
B737_5449	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5462	COG0405	Gamma-glutamyltransferase
B737_5463	COG3706	GGDEF domain
B737_5472	COG1216	Glycosyl transferase, family 2
B737_5473	COG1215	transferase activity, transferring glycosyl groups
B737_5475	COG1132	(ABC) transporter
B737_5478	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_5479	COG0596	Alpha beta hydrolase
B737_5490	COG2814	Major facilitator Superfamily
B737_5492	COG3629	intracellular signal transduction
B737_5492	COG3903	Transcriptional regulator
B737_5506	COG0330	HflC and HflK could
B737_5521	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B737_5532	COG0297	glycogen (starch) synthase activity
B737_5537	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5538	COG1309	transcriptional regulator
B737_5539	COG4941	Belongs to the sigma-70 factor family
B737_5540	COG4941	Belongs to the sigma-70 factor family
B737_5544	COG3250	beta-galactosidase activity
B737_5545	COG0583	DNA-binding transcription factor activity
B737_5552	COG0515	serine threonine protein kinase
B737_5553	COG1595	DNA-templated transcription, initiation
B737_5554	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B737_5563	COG0596	Alpha beta hydrolase
B737_5564	COG0596	Alpha beta hydrolase
B737_5566	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B737_5569	COG1672	PFAM Archaeal ATPase
B737_5569	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B737_5570	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5575	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5581	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B737_5593	COG2205	protein histidine kinase activity
B737_5594	COG0745	RESPONSE REGULATOR receiver
B737_5595	COG1216	Glycosyl transferase, family 2
B737_5596	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B737_5601	COG1609	Transcriptional regulator
B737_5603	COG1309	transcriptional regulator
B737_5614	COG4941	Belongs to the sigma-70 factor family
B737_5618	COG1335	isochorismatase
B737_5623	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_5625	COG1309	transcriptional regulator
B737_5627	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B737_5628	COG1414	Transcriptional regulator
B737_5629	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5633	COG1278	Cold shock
B737_5636	COG0300	oxidoreductase activity
B737_5638	COG3795	YCII-related domain
B737_5641	COG3263	regulation of cellular component size
B737_5642	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B737_5644	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B737_5652	COG0745	RESPONSE REGULATOR receiver
B737_5653	COG5002	protein histidine kinase activity
B737_5653	COG5000	phosphorelay sensor kinase activity
B737_5655	COG1733	regulation of RNA biosynthetic process
B737_5657	COG1846	Transcriptional regulator
B737_5658	COG0038	chloride channel
B737_5665	COG0437	4 iron, 4 sulfur cluster binding
B737_5672	COG2116	formate transmembrane transporter activity
B737_5673	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B737_5677	COG0531	amino acid
B737_5678	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B737_5681	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B737_5682	COG2080	2 iron, 2 sulfur cluster binding
B737_5684	COG0667	Aldo Keto reductase
B737_5687	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5696	COG1609	Transcriptional regulator
B737_5697	COG1609	Transcriptional regulator
B737_5701	COG1609	Transcriptional regulator
B737_5705	COG1917	Cupin 2, conserved barrel domain protein
B737_5705	COG2207	Transcriptional regulator
B737_5728	COG3293	Transposase
B737_5732	COG1857	crispr-associated protein
B737_5748	COG5297	Belongs to the glycosyl hydrolase family 6
B737_5748	COG4733	cellulase activity
B737_5753	COG0154	amidase activity
B737_5754	COG0640	Transcriptional regulator
B737_5755	COG0789	Transcriptional regulator
B737_5760	COG0673	inositol 2-dehydrogenase activity
B737_5766	COG1653	transport
B737_5772	COG3842	ATPase activity
B737_5774	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B737_5775	COG0028	Belongs to the TPP enzyme family
B737_5778	COG2197	response regulator
B737_5781	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B737_5783	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B737_5785	COG0702	epimerase
B737_5787	COG0583	DNA-binding transcription factor activity
B737_5790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B737_5801	COG0300	oxidoreductase activity
B737_5802	COG4221	oxidoreductase activity
B737_5803	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B737_5804	COG0406	alpha-ribazole phosphatase activity
B737_5804	COG0328	RNA-DNA hybrid ribonuclease activity
B737_5815	COG2318	DinB family
B737_5816	COG0667	Aldo Keto reductase
B737_5820	COG2267	carboxylic ester hydrolase activity
B737_5821	COG3629	intracellular signal transduction
B737_5821	COG3903	Transcriptional regulator
B737_5833	COG4974	Belongs to the 'phage' integrase family
B737_5834	COG1012	belongs to the aldehyde dehydrogenase family
B737_5844	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B737_5852	COG0515	serine threonine protein kinase
B737_5852	COG2815	serine threonine protein kinase
B737_5855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B737_5860	COG3511	phospholipase C
B737_5870	COG1028	Short-chain dehydrogenase reductase Sdr
B737_5879	COG0714	Associated with various cellular activities
B737_5881	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B737_5882	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B737_5884	COG1733	regulation of RNA biosynthetic process
B737_5886	COG5492	domain, Protein
B737_5889	COG4948	Mandelate Racemase Muconate Lactonizing
B737_5890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B737_5892	COG1414	Transcriptional regulator
B737_5893	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B737_5897	COG0726	polysaccharide deacetylase
B737_5913	COG1160	GTP binding
B737_5919	COG2936	dipeptidyl-peptidase activity
B737_5920	COG0475	glutathione-regulated potassium exporter activity
B737_5921	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B737_5923	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B737_5930	COG0504	CTP synthase activity
B737_5932	COG1802	Transcriptional regulator
B737_5933	COG1953	Uracil, thiamine, allantoin
B737_5940	COG1063	alcohol dehydrogenase
B737_5943	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B737_5946	COG0647	UMP catabolic process
B737_5948	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B737_5949	COG2094	Belongs to the DNA glycosylase MPG family
B737_5952	COG0165	Argininosuccinate lyase
B737_5954	COG0137	argininosuccinate synthase activity
B737_5955	COG1438	arginine binding
B737_5956	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B737_5957	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B737_5958	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B737_5959	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B737_5960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B737_5963	COG0596	Alpha beta hydrolase
B737_5965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B737_5965	COG0072	phenylalanine-tRNA ligase activity
B737_5966	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B737_5968	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B737_5969	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B737_5970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B737_5979	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B737_5980	COG2610	gluconate transmembrane transporter activity
B737_5987	COG4565	transcriptional regulatory protein
B737_5988	COG3290	protein histidine kinase activity
B737_5989	COG1301	dicarboxylic acid transport
B737_5999	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B737_6004	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B737_6005	COG0328	RNA-DNA hybrid ribonuclease activity
B737_6006	COG3012	SEC-C Motif Domain Protein
B737_6008	COG3250	beta-galactosidase activity
B737_6009	COG2272	Belongs to the type-B carboxylesterase lipase family
B737_6013	COG0406	alpha-ribazole phosphatase activity
B737_6016	COG1609	Transcriptional regulator
B737_6020	COG4946	Tricorn protease homolog
B737_6020	COG1506	peptidase
B737_6020	COG0823	Involved in the tonB-independent uptake of proteins
B737_6022	COG1131	(ABC) transporter
B737_6027	COG1024	Enoyl-CoA hydratase
B737_6034	COG0237	dephospho-CoA kinase activity
B737_6034	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B737_6039	COG0539	negative regulation of cytoplasmic translation
B737_6040	COG2226	methyltransferase
B737_6044	COG1511	domain protein
B737_6045	COG2207	Transcriptional regulator
B737_6046	COG1309	transcriptional regulator
B737_6047	COG0604	alcohol dehydrogenase
B737_6053	COG0583	DNA-binding transcription factor activity
B737_6055	COG0559	Belongs to the binding-protein-dependent transport system permease family
B737_6101	COG4585	Histidine kinase
B737_6102	COG2197	response regulator
B737_6106	COG2197	response regulator
B737_6107	COG4585	Histidine kinase
B737_6111	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B737_6112	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B737_6116	COG1454	alcohol dehydrogenase
B737_6118	COG1012	belongs to the aldehyde dehydrogenase family
B737_6122	COG0596	Alpha beta hydrolase
B737_6126	COG4977	sequence-specific DNA binding
B737_6127	COG0596	Alpha beta hydrolase
B737_6129	COG0300	oxidoreductase activity
B737_6137	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B737_6146	COG3251	PFAM MbtH domain protein
B737_6158	COG2814	Major facilitator Superfamily
B737_6160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B737_6161	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B737_6163	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B737_6164	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B737_6167	COG0768	penicillin binding
B737_6169	COG0275	rRNA processing
B737_6170	COG2001	Belongs to the MraZ family
B737_6176	COG0714	Associated with various cellular activities
B737_6178	COG1305	Transglutaminase-like
B737_6182	COG1192	Involved in chromosome partitioning
B737_6183	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B737_6184	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B737_6187	COG0167	dihydroorotate dehydrogenase activity
B737_6190	COG1396	sequence-specific DNA binding
B737_6191	COG1546	Belongs to the CinA family
B737_6191	COG1058	Belongs to the CinA family
B737_6193	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B737_6194	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B737_6200	COG1674	ftsk spoiiie
B737_6202	COG0655	NAD(P)H dehydrogenase (quinone) activity
B737_6207	COG1113	amino acid transport
B737_6208	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B737_6209	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B737_6217	COG3214	Protein conserved in bacteria
B737_6225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B737_6226	COG0612	Peptidase, M16
B737_6227	COG1185	polyribonucleotide nucleotidyltransferase activity
B737_6228	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B737_6232	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B737_6237	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B737_6239	COG2268	Band 7 protein
B737_6242	COG2226	methyltransferase
B737_6249	COG0195	Participates in both transcription termination and antitermination
B737_6250	COG0779	Required for maturation of 30S ribosomal subunits
B737_6256	COG3226	Transcriptional regulator
B737_6258	COG4585	Histidine kinase
B737_6260	COG2197	response regulator
B737_6261	COG1733	regulation of RNA biosynthetic process
B737_6263	COG1309	transcriptional regulator
B737_6264	COG2936	dipeptidyl-peptidase activity
B737_6267	COG0745	RESPONSE REGULATOR receiver
B737_6268	COG5002	protein histidine kinase activity
B737_6270	COG3629	intracellular signal transduction
B737_6270	COG3903	Transcriptional regulator
B737_6274	COG0583	DNA-binding transcription factor activity
B737_6275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_6276	COG1024	Enoyl-CoA hydratase
B737_6278	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_6279	COG1960	acyl-CoA dehydrogenase activity
B737_6280	COG1316	TRANSCRIPTIONal
B737_6285	COG0583	DNA-binding transcription factor activity
B737_6290	COG2124	cytochrome p450
B737_6298	COG3629	intracellular signal transduction
B737_6298	COG3903	Transcriptional regulator
B737_6308	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B737_6316	COG1595	DNA-templated transcription, initiation
B737_6321	COG3507	Belongs to the glycosyl hydrolase 43 family
B737_6324	COG4941	Belongs to the sigma-70 factor family
B737_6325	COG3795	YCII-related domain
B737_6326	COG2267	carboxylic ester hydrolase activity
B737_6327	COG1309	transcriptional regulator
B737_6328	COG0604	alcohol dehydrogenase
B737_6333	COG0443	Heat shock 70 kDa protein
B737_6336	COG1228	amidohydrolase
B737_6345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B737_6350	COG2197	response regulator
B737_6356	COG2755	lipolytic protein G-D-S-L family
B737_6356	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B737_6364	COG3903	Transcriptional regulator
B737_6364	COG3629	intracellular signal transduction
B737_6369	COG0667	Aldo Keto reductase
B737_6375	COG1960	acyl-CoA dehydrogenase activity
B737_6379	COG0318	PFAM AMP-dependent synthetase and ligase
B737_6381	COG0596	Alpha beta hydrolase
B737_6382	COG2197	response regulator
B737_6387	COG0477	Major facilitator Superfamily
B737_6397	COG4585	Histidine kinase
B737_6398	COG2197	response regulator
B737_6401	COG0586	Pfam SNARE associated Golgi protein
B737_6403	COG1968	undecaprenyl-diphosphatase activity
B737_6411	COG4585	Histidine kinase
B737_6412	COG2197	response regulator
B737_6415	COG1309	transcriptional regulator
B737_6417	COG0702	epimerase
B737_6418	COG0702	epimerase
B737_6423	COG2814	Major facilitator Superfamily
B737_6428	COG4977	sequence-specific DNA binding
B737_6439	COG1120	ATPase activity
B737_6440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B737_6463	COG0243	molybdopterin cofactor binding
B737_6471	COG0028	Belongs to the TPP enzyme family
B737_6472	COG4948	Mandelate Racemase Muconate Lactonizing
B737_6473	COG0277	FAD linked oxidase domain protein
B737_6473	COG0247	lactate metabolic process
B737_6477	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B737_6478	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B737_6480	COG1659	Linocin_M18 bacteriocin protein
B737_6483	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B737_6486	COG4106	trans-aconitate 2-methyltransferase activity
B737_6490	COG1595	DNA-templated transcription, initiation
B737_6492	COG0477	Major facilitator Superfamily
B737_6496	COG2318	DinB family
B737_6499	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B737_6501	COG2197	response regulator
B737_6502	COG4585	Histidine kinase
B737_6504	COG1131	(ABC) transporter
B737_6505	COG0423	glycine-tRNA ligase activity
B737_6513	COG0701	Predicted permease
B737_6515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B737_6516	COG1381	Involved in DNA repair and RecF pathway recombination
B737_6522	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B737_6525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B737_6527	COG0537	adenosine 5'-monophosphoramidase activity
B737_6529	COG0484	heat shock protein binding
B737_6530	COG1420	regulation of RNA biosynthetic process
B737_6534	COG0667	Aldo Keto reductase
B737_6542	COG2205	protein histidine kinase activity
B737_6543	COG0745	RESPONSE REGULATOR receiver
B737_6544	COG1953	Uracil, thiamine, allantoin
B737_6546	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B737_6564	COG0326	Molecular chaperone. Has ATPase activity
B737_6567	COG1024	Enoyl-CoA hydratase
B737_6568	COG2732	(Barnase) inhibitor
B737_6569	COG4290	ribonuclease
B737_6571	COG0604	alcohol dehydrogenase
B737_6573	COG2070	2-Nitropropane dioxygenase
B737_6574	COG0531	amino acid
B737_6586	COG0268	Binds directly to 16S ribosomal RNA
B737_6588	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B737_6590	COG2333	competence protein COMEC
B737_6590	COG0658	competence protein
B737_6592	COG1307	EDD domain protein, DegV family
B737_6594	COG0406	alpha-ribazole phosphatase activity
B737_6595	COG0799	negative regulation of ribosome biogenesis
B737_6596	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B737_6598	COG0477	Major facilitator Superfamily
B737_6599	COG0018	arginyl-trna synthetase
B737_6603	COG1028	Short-chain dehydrogenase reductase Sdr
B737_6605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B737_6606	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B737_6607	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B737_6608	COG1530	ribonuclease E activity
B737_6608	COG1530	ribonuclease E activity
B737_6612	COG1131	(ABC) transporter
B737_6615	COG0105	UTP biosynthetic process
B737_6617	COG2366	antibiotic biosynthetic process
B737_6619	COG0285	dihydrofolate synthase activity
B737_6624	COG0583	DNA-binding transcription factor activity
B737_6625	COG0525	valine-tRNA ligase activity
B737_6627	COG1846	Transcriptional regulator
B737_6628	COG0477	Major facilitator Superfamily
B737_6631	COG1316	TRANSCRIPTIONal
B737_6634	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B737_6640	COG0740	serine-type endopeptidase activity
B737_6641	COG0740	serine-type endopeptidase activity
B737_6642	COG0544	peptidyl-prolyl cis-trans isomerase activity
B737_6644	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B737_6646	COG2205	protein histidine kinase activity
B737_6647	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B737_6658	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B737_6667	COG3537	Alpha-1,2-mannosidase
B737_6668	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B737_6669	COG3559	Exporter of polyketide antibiotics
B737_6670	COG1131	(ABC) transporter
B737_6671	COG1309	transcriptional regulator
B737_6673	COG1940	carbohydrate kinase activity
B737_6677	COG2814	Major facilitator Superfamily
B737_6683	COG0693	protein deglycase activity
B737_6684	COG2208	phosphoserine phosphatase activity
B737_6685	COG5002	protein histidine kinase activity
B737_6685	COG0784	Response regulator, receiver
B737_6687	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B737_6690	COG1396	sequence-specific DNA binding
B737_6694	COG0583	DNA-binding transcription factor activity
B737_6696	COG1028	Short-chain dehydrogenase reductase Sdr
B737_6698	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_6701	COG1733	regulation of RNA biosynthetic process
B737_6702	COG3345	alpha-galactosidase
B737_6707	COG0459	protein refolding
B737_6709	COG0698	ribose 5-phosphate isomerase
B737_6712	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B737_6715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B737_6719	COG0668	transmembrane transport
B737_6721	COG0366	Alpha amylase catalytic
B737_6725	COG2902	Dehydrogenase
B737_6728	COG3336	cytochrome c oxidase
B737_6731	COG0738	Major facilitator superfamily
B737_6733	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B737_6734	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B737_6738	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B737_6746	COG0477	Major facilitator Superfamily
B737_6747	COG0596	Alpha beta hydrolase
B737_6751	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B737_6755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B737_6764	COG2124	cytochrome p450
B737_6771	COG1733	regulation of RNA biosynthetic process
B737_6772	COG4941	Belongs to the sigma-70 factor family
B737_6773	COG3795	YCII-related domain
B737_6775	COG0009	L-threonylcarbamoyladenylate synthase
B737_6778	COG2197	response regulator
B737_6779	COG1917	Cupin 2, conserved barrel domain protein
B737_6779	COG4977	sequence-specific DNA binding
B737_6780	COG2197	response regulator
B737_6781	COG4585	Histidine kinase
B737_6784	COG1733	regulation of RNA biosynthetic process
B737_6789	COG1937	Protein conserved in bacteria
B737_6795	COG4221	oxidoreductase activity
B737_6798	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B737_6807	COG0745	RESPONSE REGULATOR receiver
B737_6808	COG2205	protein histidine kinase activity
B737_6810	COG1609	Transcriptional regulator
B737_6817	COG0367	asparagine synthase
B737_6818	COG1940	carbohydrate kinase activity
B737_6822	COG0583	DNA-binding transcription factor activity
B737_6830	COG1609	Transcriptional regulator
B737_6837	COG0531	amino acid
B737_6838	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B737_6844	COG3835	regulator
B737_6849	COG1021	2,3-dihydroxybenzoate-AMP ligase
B737_6851	COG1733	regulation of RNA biosynthetic process
B737_6853	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B737_6855	COG0583	DNA-binding transcription factor activity
B737_6863	COG1024	Enoyl-CoA hydratase
B737_6875	COG0318	PFAM AMP-dependent synthetase and ligase
B737_6878	COG1643	Atp-dependent helicase
B737_6881	COG2072	flavoprotein involved in K transport
B737_6882	COG3268	Saccharopine dehydrogenase
B737_6885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B737_6885	COG1796	DNA polymerase
B737_6887	COG1802	Transcriptional regulator
B737_6892	COG3706	GGDEF domain
B737_6894	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B737_6897	COG4941	Belongs to the sigma-70 factor family
B737_6901	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B737_6904	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_6906	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B737_6907	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B737_6908	COG0235	Class ii aldolase
B737_6908	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B737_6911	COG1695	Transcriptional regulator
B737_6913	COG3959	Transketolase, thiamine diphosphate binding domain
B737_6914	COG1309	transcriptional regulator
B737_6915	COG0247	lactate metabolic process
B737_6915	COG0277	FAD linked oxidase domain protein
B737_6917	COG2197	response regulator
B737_6919	COG0410	ABC transporter
B737_6921	COG0559	Belongs to the binding-protein-dependent transport system permease family
B737_6922	COG0559	Belongs to the binding-protein-dependent transport system permease family
B737_6925	COG3537	Alpha-1,2-mannosidase
B737_6926	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B737_6927	COG1739	Uncharacterized protein family UPF0029
B737_6928	COG0070	glutamate synthase
B737_6928	COG0067	glutamate synthase
B737_6928	COG0069	glutamate synthase activity
B737_6930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B737_6936	COG1492	cobalamin metabolic process
B737_6937	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B737_6939	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B737_6940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B737_6942	COG2378	regulation of single-species biofilm formation
B737_6944	COG1797	cobyrinic acid a,c-diamide synthase activity
B737_6951	COG0778	Nitroreductase
B737_6957	COG1131	(ABC) transporter
B737_6960	COG1476	TRANSCRIPTIONal
B737_6962	COG3469	chitinase activity
B737_6966	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B737_6971	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B737_6973	COG0433	COG0433 Predicted ATPase
B737_6974	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B737_6976	COG0477	Major facilitator Superfamily
B737_7012	COG1960	acyl-CoA dehydrogenase activity
B737_7014	COG0022	dehydrogenase e1 component
B737_7015	COG0318	PFAM AMP-dependent synthetase and ligase
B737_7016	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7017	COG1024	Enoyl-CoA hydratase
B737_7020	COG0477	Major facilitator Superfamily
B737_7024	COG2186	Transcriptional regulator
B737_7025	COG1012	belongs to the aldehyde dehydrogenase family
B737_7026	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_7029	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7036	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B737_7038	COG1309	transcriptional regulator
B737_7040	COG0604	alcohol dehydrogenase
B737_7049	COG1960	acyl-CoA dehydrogenase activity
B737_7050	COG1960	acyl-CoA dehydrogenase activity
B737_7052	COG2186	Transcriptional regulator
B737_7055	COG0604	alcohol dehydrogenase
B737_7055	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7055	COG3321	synthase
B737_7056	COG1960	acyl-CoA dehydrogenase activity
B737_7057	COG1960	acyl-CoA dehydrogenase activity
B737_7060	COG1024	Enoyl-CoA hydratase
B737_7065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_7068	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7074	COG1414	Transcriptional regulator
B737_7076	COG2267	carboxylic ester hydrolase activity
B737_7079	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7080	COG0259	pyridoxamine-phosphate oxidase activity
B737_7081	COG0183	Belongs to the thiolase family
B737_7083	COG1024	Enoyl-CoA hydratase
B737_7084	COG1960	acyl-CoA dehydrogenase activity
B737_7088	COG0318	PFAM AMP-dependent synthetase and ligase
B737_7090	COG1024	Enoyl-CoA hydratase
B737_7092	COG1024	Enoyl-CoA hydratase
B737_7097	COG1024	Enoyl-CoA hydratase
B737_7098	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B737_7101	COG1012	belongs to the aldehyde dehydrogenase family
B737_7104	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B737_7111	COG1335	isochorismatase
B737_7114	COG1309	transcriptional regulator
B737_7116	COG0022	dehydrogenase e1 component
B737_7122	COG1063	alcohol dehydrogenase
B737_7124	COG4585	Histidine kinase
B737_7125	COG2197	response regulator
B737_7129	COG4948	Mandelate Racemase Muconate Lactonizing
B737_7130	COG2271	Major facilitator Superfamily
B737_7136	COG0235	Class ii aldolase
B737_7137	COG0477	Major facilitator Superfamily
B737_7138	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B737_7144	COG0673	inositol 2-dehydrogenase activity
B737_7145	COG2211	Major facilitator Superfamily
B737_7146	COG1609	Transcriptional regulator
B737_7147	COG1653	transport
B737_7149	COG0395	ABC-type sugar transport system, permease component
B737_7151	COG0596	Alpha beta hydrolase
B737_7153	COG0596	Alpha beta hydrolase
B737_7156	COG2084	Dehydrogenase
B737_7158	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B737_7159	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B737_7161	COG0189	ligase activity
B737_7164	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_7165	COG0625	glutathione transferase activity
B737_7167	COG2271	Major facilitator Superfamily
B737_7168	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B737_7170	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_7204	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B737_7212	COG2856	Zn peptidase
B737_7218	COG0702	epimerase
B737_7223	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B737_7224	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B737_7225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_7226	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7227	COG2169	Transcriptional regulator
B737_7227	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B737_7245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B737_7253	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B737_7254	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B737_7258	COG1960	acyl-CoA dehydrogenase activity
B737_7262	COG0154	amidase activity
B737_7265	COG0583	DNA-binding transcription factor activity
B737_7273	COG1131	(ABC) transporter
B737_7275	COG3345	alpha-galactosidase
B737_7284	COG0438	transferase activity, transferring glycosyl groups
B737_7288	COG0297	glycogen (starch) synthase activity
B737_7289	COG0438	transferase activity, transferring glycosyl groups
B737_7292	COG0463	Glycosyl transferase, family 2
B737_7299	COG3250	beta-galactosidase activity
B737_7300	COG3401	FG-GAP repeat protein
B737_7306	COG0395	ABC-type sugar transport system, permease component
B737_7307	COG1175	transmembrane transport
B737_7315	COG0596	Alpha beta hydrolase
B737_7316	COG2770	Histidine kinase
B737_7316	COG2208	phosphoserine phosphatase activity
B737_7318	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B737_7319	COG2226	methyltransferase
B737_7322	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B737_7330	COG0667	Aldo Keto reductase
B737_7331	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_7335	COG0587	DNA-directed DNA polymerase activity
B737_7336	COG4941	Belongs to the sigma-70 factor family
B737_7337	COG3795	YCII-related domain
B737_7339	COG1982	Orn Lys Arg decarboxylase major
B737_7342	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B737_7344	COG1725	Transcriptional regulator
B737_7345	COG1131	(ABC) transporter
B737_7349	COG3509	depolymerase
B737_7352	COG1528	Iron-storage protein
B737_7357	COG2018	Roadblock/LC7 domain
B737_7362	COG1764	response to oxidative stress
B737_7364	COG2267	carboxylic ester hydrolase activity
B737_7367	COG0667	Aldo Keto reductase
B737_7368	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B737_7375	COG0395	ABC-type sugar transport system, permease component
B737_7376	COG1175	transmembrane transport
B737_7377	COG1609	Transcriptional regulator
B737_7382	COG0604	alcohol dehydrogenase
B737_7388	COG1595	DNA-templated transcription, initiation
B737_7390	COG0129	dihydroxy-acid dehydratase activity
B737_7391	COG0318	PFAM AMP-dependent synthetase and ligase
B737_7392	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B737_7403	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B737_7411	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B737_7412	COG2226	methyltransferase
B737_7413	COG2508	Transcriptional regulator
B737_7415	COG3655	Transcriptional regulator
B737_7424	COG4981	capsule polysaccharide biosynthetic process
B737_7429	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_7430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B737_7442	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B737_7445	COG3226	Transcriptional regulator
B737_7457	COG0508	dehydrogenase complex catalyzes the overall conversion of
B737_7462	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_7465	COG0745	RESPONSE REGULATOR receiver
B737_7467	COG5002	protein histidine kinase activity
B737_7470	COG2815	serine threonine protein kinase
B737_7470	COG0515	serine threonine protein kinase
B737_7475	COG0640	Transcriptional regulator
B737_7477	COG2837	iron assimilation
B737_7478	COG3511	phospholipase C
B737_7481	COG0784	Response regulator, receiver
B737_7482	COG4251	negative regulation of phosphorylation
B737_7483	COG0745	RESPONSE REGULATOR receiver
B737_7499	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B737_7504	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B737_7519	COG1309	transcriptional regulator
B737_7523	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B737_7524	COG1309	transcriptional regulator
B737_7528	COG3383	formate dehydrogenase (NAD+) activity
B737_7529	COG0318	PFAM AMP-dependent synthetase and ligase
B737_7530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_7532	COG1733	regulation of RNA biosynthetic process
B737_7539	COG2814	Major facilitator Superfamily
B737_7546	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7551	COG0706	membrane insertase activity
B737_7554	COG1408	metallophosphoesterase
B737_7556	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B737_7558	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B737_7562	COG2018	Roadblock/LC7 domain
B737_7565	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7569	COG3706	GGDEF domain
B737_7571	COG1316	TRANSCRIPTIONal
B737_7578	COG4977	sequence-specific DNA binding
B737_7579	COG0667	Aldo Keto reductase
B737_7580	COG2207	Transcriptional regulator
B737_7585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B737_7587	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B737_7588	COG1234	tRNA 3'-trailer cleavage
B737_7589	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B737_7591	COG1794	racemase activity, acting on amino acids and derivatives
B737_7593	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B737_7597	COG3191	aminopeptidase activity
B737_7601	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B737_7602	COG1335	isochorismatase
B737_7603	COG0800	Aldolase
B737_7605	COG1268	BioY protein
B737_7611	COG0560	Phosphoserine phosphatase
B737_7611	COG3830	Belongs to the UPF0237 family
B737_7612	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B737_7613	COG2267	carboxylic ester hydrolase activity
B737_7618	COG2801	Transposase and inactivated derivatives
B737_7621	COG0626	cystathionine gamma-synthase activity
B737_7622	COG1522	sequence-specific DNA binding
B737_7624	COG1522	sequence-specific DNA binding
B737_7631	COG2376	Dihydroxyacetone kinase
B737_7637	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B737_7639	COG1051	belongs to the nudix hydrolase family
B737_7641	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B737_7642	COG4977	sequence-specific DNA binding
B737_7644	COG1335	isochorismatase
B737_7647	COG1280	lysine exporter protein (LysE YggA)
B737_7649	COG1280	lysine exporter protein (LysE YggA)
B737_7650	COG0702	epimerase
B737_7651	COG3631	Ketosteroid isomerase-related protein
B737_7652	COG1309	transcriptional regulator
B737_7654	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B737_7657	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B737_7658	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B737_7659	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B737_7660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B737_7661	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B737_7662	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B737_7663	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B737_7664	COG0356	it plays a direct role in the translocation of protons across the membrane
B737_7666	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B737_7669	COG2890	protein-(glutamine-N5) methyltransferase activity
B737_7670	COG0463	Glycosyl transferase, family 2
B737_7674	COG0254	rRNA binding
B737_7676	COG0083	homoserine kinase activity
B737_7677	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B737_7678	COG0460	homoserine dehydrogenase
B737_7679	COG0019	diaminopimelate decarboxylase activity
B737_7680	COG0018	arginyl-trna synthetase
B737_7686	COG0596	Alpha beta hydrolase
B737_7700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B737_7702	COG3903	Transcriptional regulator
B737_7702	COG3629	intracellular signal transduction
B737_7703	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B737_7703	COG2124	cytochrome p450
B737_7707	COG3345	alpha-galactosidase
B737_7712	COG3693	PFAM glycoside hydrolase, family 10
B737_7725	COG5433	transposase activity
B737_7735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B737_7736	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B737_7740	COG1028	Short-chain dehydrogenase reductase Sdr
B737_7742	COG0145	ligase activity
B737_7746	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B737_7749	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B737_7752	COG0154	amidase activity
B737_7758	COG0473	3-isopropylmalate dehydrogenase activity
B737_7762	COG0667	Aldo Keto reductase
B737_7766	COG0028	Belongs to the TPP enzyme family
B737_7771	COG4585	Histidine kinase
B737_7772	COG2197	response regulator
B737_7773	COG3537	Alpha-1,2-mannosidase
B737_7774	COG2409	Drug exporters of the RND superfamily
B737_7775	COG1024	Enoyl-CoA hydratase
B737_7775	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_7776	COG0183	Belongs to the thiolase family
B737_7777	COG1309	transcriptional regulator
B737_7784	COG1960	acyl-CoA dehydrogenase activity
B737_7785	COG1960	acyl-CoA dehydrogenase activity
B737_7796	COG4221	oxidoreductase activity
B737_7802	COG1960	acyl-CoA dehydrogenase activity
B737_7804	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B737_7810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B737_7812	COG0346	lactoylglutathione lyase activity
B737_7817	COG2226	methyltransferase
B737_7818	COG2508	Transcriptional regulator
B737_7818	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B737_7821	COG0686	Belongs to the AlaDH PNT family
B737_7823	COG2205	protein histidine kinase activity
B737_7825	COG0745	RESPONSE REGULATOR receiver
B737_7828	COG1132	(ABC) transporter
B737_7831	COG0508	dehydrogenase complex catalyzes the overall conversion of
B737_7831	COG0567	Dehydrogenase, E1 component
B737_7833	COG1216	Glycosyl transferase, family 2
B737_7834	COG2223	nitrite transmembrane transporter activity
B737_7836	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_7839	COG1174	glycine betaine transport
B737_7840	COG1174	glycine betaine transport
B737_7841	COG0517	IMP dehydrogenase activity
B737_7841	COG1125	glycine betaine transport
B737_7844	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B737_7846	COG1846	Transcriptional regulator
B737_7849	COG0406	alpha-ribazole phosphatase activity
B737_7852	COG1597	lipid kinase activity
B737_7856	COG1595	DNA-templated transcription, initiation
B737_7857	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B737_7859	COG2135	peptidase activity
B737_7865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B737_7866	COG1011	Hydrolase
B737_7869	COG0653	protein targeting
B737_7870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B737_7872	COG5401	PFAM Sporulation and spore germination
B737_7873	COG5000	phosphorelay sensor kinase activity
B737_7873	COG5002	protein histidine kinase activity
B737_7874	COG0745	RESPONSE REGULATOR receiver
B737_7877	COG1414	Transcriptional regulator
B737_7890	COG0531	amino acid
B737_7892	COG3629	intracellular signal transduction
B737_7892	COG3903	Transcriptional regulator
B737_7893	COG1482	cell wall glycoprotein biosynthetic process
B737_7895	COG2835	tetraacyldisaccharide 4'-kinase activity
B737_7896	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B737_7904	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B737_7907	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B737_7908	COG0601	transmembrane transport
B737_7910	COG0747	negative chemotaxis
B737_7913	COG0180	Tryptophanyl-tRNA synthetase
B737_7915	COG2205	protein histidine kinase activity
B737_7916	COG0745	RESPONSE REGULATOR receiver
B737_7918	COG1131	(ABC) transporter
B737_7920	COG3842	ATPase activity
B737_7921	COG4149	molybdate abc transporter
B737_7923	COG2154	pterin-4-alpha-carbinolamine dehydratase
B737_7927	COG0012	GTP binding
B737_7930	COG0419	ATPase involved in DNA repair
B737_7931	COG0420	3'-5' exonuclease activity
B737_7934	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B737_7936	COG1570	exodeoxyribonuclease VII activity
B737_7938	COG1722	exodeoxyribonuclease VII activity
B737_7941	COG0492	ferredoxin-NADP+ reductase activity
B737_7942	COG0114	fumarate hydratase activity
B737_7944	COG1793	dna ligase
B737_7947	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B737_7953	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B737_7958	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
B737_7964	COG1331	Highly conserved protein containing a thioredoxin domain
B737_7966	COG2890	protein-(glutamine-N5) methyltransferase activity
B737_7967	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B737_7969	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B737_7971	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B737_7972	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B737_7974	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B737_7980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B737_7987	COG0183	Belongs to the thiolase family
B737_7998	COG2723	6-phospho-beta-galactosidase activity
B737_7999	COG3629	intracellular signal transduction
B737_7999	COG3903	Transcriptional regulator
B737_8001	COG1175	transmembrane transport
B737_8004	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_8005	COG0667	Aldo Keto reductase
B737_8006	COG0477	Major facilitator Superfamily
B737_8013	COG2207	Transcriptional regulator
B737_8016	COG5297	Belongs to the glycosyl hydrolase family 6
B737_8019	COG2205	protein histidine kinase activity
B737_8020	COG0148	phosphopyruvate hydratase activity
B737_8022	COG1132	(ABC) transporter
B737_8041	COG1595	DNA-templated transcription, initiation
B737_8042	COG0515	serine threonine protein kinase
B737_8042	COG2815	serine threonine protein kinase
B737_8049	COG1191	sigma factor activity
B737_8062	COG1515	deoxyribonuclease V activity
B737_8065	COG4608	Belongs to the ABC transporter superfamily
B737_8066	COG0444	Belongs to the ABC transporter superfamily
B737_8074	COG0148	phosphopyruvate hydratase activity
B737_8078	COG0672	)-iron permease
B737_8079	COG2822	iron ion transport
B737_8080	COG2837	iron assimilation
B737_8086	COG1131	(ABC) transporter
B737_8095	COG0586	Pfam SNARE associated Golgi protein
B737_8098	COG4585	Histidine kinase
B737_8099	COG2197	response regulator
B737_8100	COG2133	pyrroloquinoline quinone binding
B737_8104	COG1051	belongs to the nudix hydrolase family
B737_8105	COG1309	transcriptional regulator
B737_8108	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B737_8114	COG0193	aminoacyl-tRNA hydrolase activity
B737_8117	COG0318	PFAM AMP-dependent synthetase and ligase
B737_8118	COG0488	(ABC) transporter
B737_8120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B737_8121	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B737_8122	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B737_8123	COG3583	domain protein
B737_8124	COG0084	hydrolase, TatD family'
B737_8125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B737_8136	COG2815	serine threonine protein kinase
B737_8136	COG0515	serine threonine protein kinase
B737_8137	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B737_8141	COG2258	MOSC domain
B737_8144	COG1595	DNA-templated transcription, initiation
B737_8152	COG5001	Diguanylate cyclase
B737_8154	COG2124	cytochrome p450
B737_8155	COG1192	Involved in chromosome partitioning
B737_8160	COG0745	RESPONSE REGULATOR receiver
B737_8161	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B737_8162	COG2205	protein histidine kinase activity
B737_8163	COG1181	Belongs to the D-alanine--D-alanine ligase family
B737_8165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B737_8166	COG1733	regulation of RNA biosynthetic process
B737_8167	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B737_8168	COG3433	isochorismatase activity
B737_8168	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B737_8168	COG2226	methyltransferase
B737_8171	COG1280	lysine exporter protein (LysE YggA)
B737_8173	COG0515	serine threonine protein kinase
B737_8182	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B737_8184	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B737_8185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B737_8190	COG0521	Mo-molybdopterin cofactor biosynthetic process
B737_8190	COG0315	cyclic pyranopterin monophosphate synthase activity
B737_8194	COG5002	protein histidine kinase activity
B737_8195	COG0745	RESPONSE REGULATOR receiver
B737_8199	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B737_8204	COG1349	DNA-binding transcription factor activity
B737_8207	COG2860	membrane
B737_8208	COG2197	response regulator
B737_8209	COG2264	protein methyltransferase activity
B737_8210	COG0477	Major facilitator Superfamily
B737_8211	COG0667	Aldo Keto reductase
B737_8213	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B737_8216	COG2815	serine threonine protein kinase
B737_8216	COG0515	serine threonine protein kinase
B737_8217	COG0483	inositol monophosphate 1-phosphatase activity
B737_8218	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B737_8222	COG0297	glycogen (starch) synthase activity
B737_8226	COG1793	dna ligase
B737_8226	COG3285	dna ligase
B737_8228	COG0583	DNA-binding transcription factor activity
B737_8231	COG2755	lipolytic protein G-D-S-L family
B737_8231	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B737_8242	COG0444	Belongs to the ABC transporter superfamily
B737_8243	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B737_8244	COG0601	transmembrane transport
B737_8246	COG0747	negative chemotaxis
B737_8252	COG3469	chitinase activity
B737_8255	COG4336	lyase activity
B737_8256	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B737_8257	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B737_8258	COG1984	allophanate hydrolase subunit 2
B737_8266	COG1321	iron dependent repressor
B737_8270	COG1024	Enoyl-CoA hydratase
B737_8271	COG0318	PFAM AMP-dependent synthetase and ligase
B737_8275	COG1169	isochorismate synthase
B737_8279	COG2182	Extracellular solute-binding protein
B737_8280	COG1175	transmembrane transport
B737_8281	COG0395	ABC-type sugar transport system, permease component
B737_8286	COG1595	DNA-templated transcription, initiation
B737_8288	COG0277	FAD linked oxidase domain protein
B737_8294	COG4152	abc transporter atp-binding protein
B737_8296	COG0415	Belongs to the DNA photolyase family
B737_8301	COG1960	acyl-CoA dehydrogenase activity
B737_8306	COG2017	converts alpha-aldose to the beta-anomer
B737_8308	COG1309	transcriptional regulator
B737_8313	COG0259	pyridoxamine-phosphate oxidase activity
B737_8317	COG0829	nickel cation binding
B737_8318	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B737_8320	COG0804	urea catabolic process
B737_8321	COG0832	Belongs to the urease beta subunit family
B737_8322	COG0831	urea catabolic process
B737_8329	COG2197	response regulator
B737_8330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B737_8332	COG5650	phosphatidylinositol metabolic process
B737_8334	COG1228	amidohydrolase
B737_8335	COG0577	efflux transmembrane transporter activity
B737_8335	COG1136	(ABC) transporter
B737_8336	COG1136	(ABC) transporter
B737_8336	COG0577	efflux transmembrane transporter activity
B737_8339	COG0745	RESPONSE REGULATOR receiver
B737_8340	COG2205	protein histidine kinase activity
B737_8345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B737_8350	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B737_8351	COG2814	Major facilitator Superfamily
B737_8354	COG2252	PERMEase
B737_8359	COG2814	Major facilitator Superfamily
B737_8360	COG1278	Cold shock
B737_8365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B737_8366	COG0318	PFAM AMP-dependent synthetase and ligase
B737_8368	COG1595	DNA-templated transcription, initiation
B737_8370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B737_8378	COG0384	phenazine biosynthesis protein PhzF
B737_8379	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B737_8380	COG3304	Inner membrane component domain
B737_8387	COG1846	Transcriptional regulator
B737_8388	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B737_8390	COG1388	LysM domain
B737_8399	COG2018	Roadblock/LC7 domain
B737_8402	COG2018	Roadblock/LC7 domain
B737_8403	COG0642	Histidine kinase
B737_8404	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B737_8405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B737_8406	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B737_8407	COG1116	anion transmembrane transporter activity
B737_8413	COG3142	Participates in the control of copper homeostasis
B737_8417	COG1061	Type III restriction enzyme res subunit
B737_8421	COG4948	Mandelate Racemase Muconate Lactonizing
B737_8424	COG0459	protein refolding
B737_8426	COG1278	Cold shock
B737_8432	COG2261	transglycosylase associated protein
B737_8433	COG0688	phosphatidylethanolamine metabolic process
B737_8435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B737_8438	COG0242	peptide deformylase activity
B737_8440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B737_8441	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B737_8442	COG0351	phosphomethylpyrimidine kinase
B737_8446	COG2022	thiamine diphosphate biosynthetic process
B737_8449	COG0352	thiamine-phosphate diphosphorylase activity
B737_8451	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B737_8452	COG0477	Major facilitator Superfamily
B737_8454	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B737_8455	COG2971	BadF BadG BcrA BcrD
B737_8457	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B737_8463	COG3903	Transcriptional regulator
B737_8463	COG3629	intracellular signal transduction
B737_8464	COG5285	phytanoyl-CoA dioxygenase
B737_8465	COG1917	Cupin 2, conserved barrel domain protein
B737_8468	COG1752	Esterase of the alpha-beta hydrolase superfamily
B737_8470	COG4399	Belongs to the UPF0754 family
B737_8471	COG1733	regulation of RNA biosynthetic process
B737_8473	COG5416	Lipopolysaccharide assembly protein A domain
B737_8486	COG1733	regulation of RNA biosynthetic process
B737_8494	COG0346	lactoylglutathione lyase activity
B737_8497	COG1832	CoA-binding protein
B737_8505	COG0745	RESPONSE REGULATOR receiver
B737_8506	COG2205	protein histidine kinase activity
B737_8507	COG1492	cobalamin metabolic process
B737_8508	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B737_8510	COG1309	transcriptional regulator
B737_8512	COG1620	l-lactate permease
B737_8513	COG4941	Belongs to the sigma-70 factor family
B737_8515	COG3795	YCII-related domain
B737_8516	COG3795	YCII-related domain
B737_8519	COG2205	protein histidine kinase activity
B737_8526	COG1595	DNA-templated transcription, initiation
B737_8536	COG0789	Transcriptional regulator
B737_8539	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B737_8546	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B737_8548	COG1329	Transcriptional regulator
B737_8549	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B737_8550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B737_8554	COG0215	cysteine-tRNA ligase activity
B737_8561	COG0235	Class ii aldolase
B737_8565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B737_8566	COG4399	Belongs to the UPF0754 family
B737_8567	COG1121	(ABC) transporter
B737_8568	COG0803	Belongs to the bacterial solute-binding protein 9 family
B737_8569	COG1609	Transcriptional regulator
B737_8575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B737_8578	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B737_8594	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B737_8596	COG1396	sequence-specific DNA binding
B737_8602	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B737_8604	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B737_8605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B737_8606	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B737_8611	COG0789	Transcriptional regulator
B737_8614	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B737_8616	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B737_8622	COG0037	tRNA processing
B737_8625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B737_8627	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B737_8628	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B737_8644	COG2188	Transcriptional regulator
B737_8648	COG1674	ftsk spoiiie
B737_8655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B737_8656	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B737_8662	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B737_8662	COG1754	DNA topoisomerase type I activity
B737_8666	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B737_8667	COG1111	helicase
B737_8667	COG1205	dead DEAH box helicase
B737_8676	COG1472	Belongs to the glycosyl hydrolase 3 family
B737_8677	COG3876	Protein conserved in bacteria
B737_8678	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B737_8679	COG1737	Transcriptional regulator
B737_8680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B737_8682	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B737_8683	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B737_8685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B737_8689	COG3104	oligopeptide transport
B737_8690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B737_8693	COG0596	Alpha beta hydrolase
B737_8708	COG2272	Belongs to the type-B carboxylesterase lipase family
B737_8709	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B737_8719	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B737_8721	COG1408	metallophosphoesterase
B737_8722	COG2226	methyltransferase
B737_8729	COG0463	Glycosyl transferase, family 2
B737_8730	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B737_8732	COG2192	nodulation
B737_8735	COG0076	glutamate decarboxylase activity
B737_8736	COG0783	Belongs to the Dps family
B737_8737	COG1764	response to oxidative stress
B737_8742	COG2814	Major facilitator Superfamily
B737_8745	COG1690	Belongs to the RtcB family
B737_8752	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B737_8757	COG0583	DNA-binding transcription factor activity
B737_8760	COG0697	spore germination
B737_8762	COG3795	YCII-related domain
B737_8763	COG4941	Belongs to the sigma-70 factor family
B737_8764	COG4608	Belongs to the ABC transporter superfamily
B737_8768	COG0747	negative chemotaxis
B737_8770	COG1216	Glycosyl transferase, family 2
B737_8774	COG1215	transferase activity, transferring glycosyl groups
B737_8776	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B737_8777	COG1705	Flagellar rod assembly protein muramidase FlgJ
B737_8778	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B737_8779	COG1733	regulation of RNA biosynthetic process
B737_8781	COG3467	pyridoxamine 5'-phosphate
B737_8782	COG2801	Transposase and inactivated derivatives
B737_8791	COG1116	anion transmembrane transporter activity
B737_8792	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B737_8794	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B737_8795	COG2205	protein histidine kinase activity
B737_8796	COG0745	RESPONSE REGULATOR receiver
B737_8799	COG2197	response regulator
B737_8803	COG1250	3-hydroxyacyl-CoA dehydrogenase
B737_8804	COG5479	isomerase activity
B737_8804	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B737_8812	COG1674	ftsk spoiiie
B737_8820	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
B737_8821	COG2175	clavaminate synthase activity
B737_8831	COG4702	Belongs to the UPF0303 family
B737_8833	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B737_8834	COG0789	Transcriptional regulator
B737_8835	COG0395	ABC-type sugar transport system, permease component
B737_8836	COG1175	transmembrane transport
B737_8839	COG1802	Transcriptional regulator
B737_8845	COG3973	AAA domain
B737_8851	COG0673	inositol 2-dehydrogenase activity
B737_8854	COG3345	alpha-galactosidase
B737_8857	COG2188	Transcriptional regulator
B737_8858	COG1397	ADP-ribosylglycohydrolase
B737_8859	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B737_8862	COG0596	Alpha beta hydrolase
B737_8863	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B737_8864	COG3706	GGDEF domain
B737_8864	COG0745	RESPONSE REGULATOR receiver
B737_8866	COG1316	TRANSCRIPTIONal
B737_8868	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B737_8869	COG0581	inorganic phosphate transmembrane transporter activity
B737_8871	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B737_8873	COG0745	RESPONSE REGULATOR receiver
B737_8879	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B737_8880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B737_8881	COG1984	allophanate hydrolase subunit 2
B737_8891	COG3845	ABC transporter
B737_8898	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B737_8911	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B737_8913	COG1132	(ABC) transporter
B737_8914	COG0047	phosphoribosylformylglycinamidine synthase activity
B737_8915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B737_8924	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B737_8926	COG1126	abc transporter atp-binding protein
B737_8927	COG0765	amino acid transport
B737_8929	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B737_8931	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B737_8932	COG4948	Mandelate Racemase Muconate Lactonizing
B737_8936	COG2186	Transcriptional regulator
B737_8940	COG0546	phosphoglycolate phosphatase activity
B737_8943	COG0436	Aminotransferase
B737_8944	COG3953	SLT domain
B737_8944	COG5280	Phage tail tape measure protein TP901
B737_8951	COG0584	glycerophosphoryl diester phosphodiesterase
B737_8956	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B737_8958	COG2814	Major facilitator Superfamily
B737_8959	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B737_8960	COG0025	NhaP-type Na H and K H
B737_8962	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B737_8969	COG3706	GGDEF domain
B737_8969	COG0745	RESPONSE REGULATOR receiver
B737_8976	COG0667	Aldo Keto reductase
B737_8977	COG1028	Short-chain dehydrogenase reductase Sdr
B737_8987	COG0586	Pfam SNARE associated Golgi protein
B737_8989	COG0277	FAD linked oxidase domain protein
B737_8990	COG3467	pyridoxamine 5'-phosphate
B737_8994	COG0586	Pfam SNARE associated Golgi protein
B737_8997	COG1028	Short-chain dehydrogenase reductase Sdr
B737_8998	COG0572	uridine kinase
B737_8999	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B737_9006	COG0243	molybdopterin cofactor binding
B737_9015	COG1136	(ABC) transporter
B737_9016	COG4221	oxidoreductase activity
B737_9019	COG0542	response to heat
B737_9024	COG0412	Dienelactone hydrolase
B737_9027	COG0789	Transcriptional regulator
B737_9028	COG0484	heat shock protein binding
B737_9029	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B737_9030	COG0443	Heat shock 70 kDa protein
B737_9037	COG2181	nitrate reductase activity
B737_9037	COG0247	lactate metabolic process
B737_9040	COG2340	Cysteine-rich secretory protein family
B737_9047	COG4941	Belongs to the sigma-70 factor family
B737_9048	COG3795	YCII-related domain
B737_9050	COG2124	cytochrome p450
B737_9058	COG3663	DNA glycosylase
B737_9059	COG2197	response regulator
B737_9060	COG1960	acyl-CoA dehydrogenase activity
B737_9062	COG0477	Major facilitator Superfamily
B737_9066	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B737_9071	COG1126	abc transporter atp-binding protein
B737_9077	COG1305	Transglutaminase-like
B737_9078	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B737_9081	COG0022	dehydrogenase e1 component
B737_9082	COG0508	dehydrogenase complex catalyzes the overall conversion of
B737_9087	COG3030	protein affecting phage T7 exclusion by the F plasmid
B737_9095	COG2030	dehydratase
B737_9096	COG1309	transcriptional regulator
B737_9097	COG1028	Short-chain dehydrogenase reductase Sdr
B737_9098	COG0183	Belongs to the thiolase family
B737_9113	COG1131	(ABC) transporter
B737_9116	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B737_9119	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B737_9122	COG4585	Histidine kinase
B737_9123	COG2197	response regulator
B737_9124	COG1028	Short-chain dehydrogenase reductase Sdr
B737_9128	COG1131	(ABC) transporter
B737_9131	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B737_9133	COG1136	(ABC) transporter
B737_9136	COG2197	response regulator
B737_9138	COG4221	oxidoreductase activity
B737_9139	COG0402	S-adenosylhomocysteine deaminase activity
B737_9142	COG2814	Major facilitator Superfamily
B737_9143	COG1846	Transcriptional regulator
B737_9145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B737_9146	COG1595	DNA-templated transcription, initiation
B737_9148	COG1695	Transcriptional regulator
B737_9150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B737_9151	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B737_9152	COG0673	inositol 2-dehydrogenase activity
B737_9153	COG1940	carbohydrate kinase activity
B737_9159	COG0360	Binds together with S18 to 16S ribosomal RNA
B737_9161	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B737_9162	COG0359	binds to the 23S rRNA
B737_9170	COG3384	dioxygenase
B737_9175	COG2197	response regulator
B737_9178	COG0477	Major facilitator Superfamily
B737_9179	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B737_9181	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B737_9191	COG1028	Short-chain dehydrogenase reductase Sdr
B737_9193	COG0495	leucyl-tRNA aminoacylation
B737_9195	COG1678	Uncharacterized ACR, COG1678
B737_9209	COG0617	tRNA 3'-terminal CCA addition
B737_9217	COG0492	ferredoxin-NADP+ reductase activity
B737_9217	COG3118	belongs to the thioredoxin family
B737_9218	COG0860	N-Acetylmuramoyl-L-alanine amidase
B737_9218	COG3409	Peptidoglycan-binding domain 1 protein
B737_9221	COG1181	Belongs to the D-alanine--D-alanine ligase family
B737_9223	COG1192	Involved in chromosome partitioning
B737_9224	COG0357	Ribosomal RNA small subunit methyltransferase G
B737_9227	COG0706	membrane insertase activity
B737_9228	COG0759	Could be involved in insertion of integral membrane proteins into the membrane