locus-tag	class	description
AMES_0002	COG0592	DNA-directed DNA polymerase activity
AMES_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMES_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMES_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AMES_0006	COG0187	DNA topoisomerase II activity
AMES_0025	COG0596	Alpha beta hydrolase
AMES_0034	COG0705	Rhomboid family
AMES_0034	COG0457	Tetratricopeptide repeat
AMES_0036	COG3764	Sortase (surface protein transpeptidase)
AMES_0048	COG0515	serine threonine protein kinase
AMES_0048	COG2815	serine threonine protein kinase
AMES_0049	COG0515	serine threonine protein kinase
AMES_0050	COG0768	penicillin binding
AMES_0053	COG1716	ATPase activity
AMES_0054	COG1716	ATPase activity
AMES_0059	COG0626	cystathionine gamma-synthase activity
AMES_0063	COG2186	Transcriptional regulator
AMES_0064	COG0747	negative chemotaxis
AMES_0067	COG0444	Belongs to the ABC transporter superfamily
AMES_0068	COG4608	Belongs to the ABC transporter superfamily
AMES_0069	COG1012	belongs to the aldehyde dehydrogenase family
AMES_0070	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_0071	COG0154	amidase activity
AMES_0076	COG2301	Belongs to the HpcH HpaI aldolase family
AMES_0078	COG0702	epimerase
AMES_0080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMES_0082	COG1309	transcriptional regulator
AMES_0084	COG2211	Major facilitator Superfamily
AMES_0090	COG2372	response to copper ion
AMES_0090	COG1276	copper resistance
AMES_0093	COG1174	glycine betaine transport
AMES_0095	COG1174	glycine betaine transport
AMES_0100	COG2226	methyltransferase
AMES_0102	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMES_0104	COG0405	Gamma-glutamyltransferase
AMES_0105	COG5433	transposase activity
AMES_0108	COG0477	Major facilitator Superfamily
AMES_0110	COG4585	Histidine kinase
AMES_0111	COG2197	response regulator
AMES_0117	COG0438	transferase activity, transferring glycosyl groups
AMES_0127	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMES_0128	COG3275	phosphorelay sensor kinase activity
AMES_0133	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMES_0134	COG0425	Belongs to the sulfur carrier protein TusA family
AMES_0134	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMES_0138	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMES_0142	COG1191	sigma factor activity
AMES_0145	COG2235	arginine
AMES_0160	COG1271	oxidase subunit
AMES_0161	COG1294	oxidase, subunit
AMES_0162	COG4988	ABC transporter
AMES_0173	COG4715	Zinc finger, swim domain protein
AMES_0175	COG1072	(Pantothenic acid kinase))
AMES_0176	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMES_0178	COG0406	alpha-ribazole phosphatase activity
AMES_0185	COG0754	glutathionylspermidine amidase activity
AMES_0187	COG0596	Alpha beta hydrolase
AMES_0188	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMES_0189	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMES_0190	COG0579	oxidoreductase
AMES_0196	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AMES_0199	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMES_0205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMES_0207	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_0208	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_0216	COG0561	phosphatase activity
AMES_0217	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_0221	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMES_0224	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_0225	COG0277	FAD linked oxidase domain protein
AMES_0227	COG1216	Glycosyl transferase, family 2
AMES_0233	COG1216	Glycosyl transferase, family 2
AMES_0237	COG0604	alcohol dehydrogenase
AMES_0237	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_0237	COG3321	synthase
AMES_0239	COG2234	aminopeptidase activity
AMES_0250	COG4565	transcriptional regulatory protein
AMES_0251	COG3290	protein histidine kinase activity
AMES_0252	COG1116	anion transmembrane transporter activity
AMES_0257	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMES_0257	COG1672	PFAM Archaeal ATPase
AMES_0260	COG1522	sequence-specific DNA binding
AMES_0262	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMES_0263	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMES_0264	COG2186	Transcriptional regulator
AMES_0267	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMES_0269	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMES_0273	COG3469	chitinase activity
AMES_0274	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AMES_0279	COG3583	domain protein
AMES_0279	COG3584	3D domain protein
AMES_0292	COG3559	Exporter of polyketide antibiotics
AMES_0294	COG1131	(ABC) transporter
AMES_0305	COG0287	Prephenate dehydrogenase
AMES_0306	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMES_0306	COG1902	pentaerythritol trinitrate reductase activity
AMES_0310	COG1846	Transcriptional regulator
AMES_0316	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMES_0318	COG2318	DinB family
AMES_0320	COG0194	GDP metabolic process
AMES_0331	COG0515	serine threonine protein kinase
AMES_0334	COG0028	Belongs to the TPP enzyme family
AMES_0337	COG3199	ATP-NAD kinase
AMES_0338	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMES_0341	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMES_0342	COG0515	serine threonine protein kinase
AMES_0344	COG0477	Major facilitator Superfamily
AMES_0345	COG1595	DNA-templated transcription, initiation
AMES_0348	COG1278	Cold shock
AMES_0379	COG2226	methyltransferase
AMES_0386	COG2233	PERMEase
AMES_0388	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMES_0390	COG1414	Transcriptional regulator
AMES_0394	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AMES_0412	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AMES_0415	COG2364	Membrane
AMES_0417	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_0420	COG2733	membrane
AMES_0425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMES_0431	COG2986	histidine ammonia-lyase
AMES_0436	COG1174	glycine betaine transport
AMES_0439	COG1846	Transcriptional regulator
AMES_0442	COG2130	NADP-dependent
AMES_0444	COG1064	alcohol dehydrogenase
AMES_0450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMES_0453	COG0438	transferase activity, transferring glycosyl groups
AMES_0456	COG0588	phosphoglycerate mutase activity
AMES_0458	COG0667	Aldo Keto reductase
AMES_0459	COG5002	protein histidine kinase activity
AMES_0465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMES_0469	COG4585	Histidine kinase
AMES_0472	COG0560	Phosphoserine phosphatase
AMES_0474	COG1595	DNA-templated transcription, initiation
AMES_0475	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_0478	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMES_0479	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMES_0480	COG0181	hydroxymethylbilane synthase activity
AMES_0481	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMES_0481	COG1648	precorrin-2 dehydrogenase activity
AMES_0488	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMES_0489	COG0577	efflux transmembrane transporter activity
AMES_0489	COG1136	(ABC) transporter
AMES_0490	COG0577	efflux transmembrane transporter activity
AMES_0490	COG1136	(ABC) transporter
AMES_0493	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMES_0494	COG0406	alpha-ribazole phosphatase activity
AMES_0495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMES_0496	COG0785	Cytochrome C biogenesis protein
AMES_0498	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMES_0502	COG1522	sequence-specific DNA binding
AMES_0508	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AMES_0513	COG0438	transferase activity, transferring glycosyl groups
AMES_0516	COG2226	methyltransferase
AMES_0517	COG0644	oxidoreductase
AMES_0519	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMES_0520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMES_0521	COG0649	NAD binding
AMES_0524	COG1034	ATP synthesis coupled electron transport
AMES_0525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMES_0526	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMES_0527	COG0839	Belongs to the complex I subunit 6 family
AMES_0528	COG0713	ATP synthesis coupled electron transport
AMES_0529	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMES_0531	COG1007	ATP synthesis coupled electron transport
AMES_0538	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMES_0539	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMES_0539	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMES_0541	COG1522	sequence-specific DNA binding
AMES_0542	COG1834	amidinotransferase
AMES_0545	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMES_0546	COG0438	transferase activity, transferring glycosyl groups
AMES_0549	COG0367	asparagine synthase
AMES_0558	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMES_0559	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMES_0561	COG1215	transferase activity, transferring glycosyl groups
AMES_0563	COG4310	Domain of unknown function (DUF2172)
AMES_0566	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMES_0569	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_0577	COG1666	GTP binding
AMES_0580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMES_0584	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMES_0585	COG2030	dehydratase
AMES_0589	COG1725	Transcriptional regulator
AMES_0593	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMES_0594	COG0081	regulation of translation
AMES_0597	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMES_0601	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMES_0606	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMES_0611	COG0673	inositol 2-dehydrogenase activity
AMES_0623	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMES_0624	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMES_0627	COG0546	phosphoglycolate phosphatase activity
AMES_0629	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMES_0631	COG0477	Major facilitator Superfamily
AMES_0634	COG2124	cytochrome p450
AMES_0635	COG2124	cytochrome p450
AMES_0639	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMES_0642	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_0647	COG2124	cytochrome p450
AMES_0649	COG3959	Transketolase, thiamine diphosphate binding domain
AMES_0650	COG3958	Transketolase
AMES_0652	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMES_0655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMES_0657	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMES_0658	COG1522	sequence-specific DNA binding
AMES_0659	COG0477	Major facilitator Superfamily
AMES_0661	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_0661	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMES_0670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMES_0671	COG0049	tRNA binding
AMES_0672	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMES_0674	COG0051	transcription antitermination factor activity, RNA binding
AMES_0675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMES_0676	COG0088	Forms part of the polypeptide exit tunnel
AMES_0677	COG0089	rRNA binding
AMES_0678	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMES_0679	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMES_0680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMES_0681	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMES_0682	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMES_0683	COG0255	Belongs to the universal ribosomal protein uL29 family
AMES_0684	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMES_0685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMES_0686	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMES_0687	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMES_0689	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMES_0690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMES_0691	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMES_0692	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMES_0693	COG1841	ribosomal large subunit assembly
AMES_0694	COG0200	Binds to the 23S rRNA
AMES_0696	COG1280	lysine exporter protein (LysE YggA)
AMES_0698	COG0563	adenylate kinase activity
AMES_0701	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMES_0702	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMES_0704	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMES_0705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMES_0706	COG0202	RNA polymerase activity
AMES_0707	COG0203	ribosomal protein L17
AMES_0708	COG0101	tRNA pseudouridine synthase activity
AMES_0715	COG1404	Belongs to the peptidase S8 family
AMES_0717	COG1674	ftsk spoiiie
AMES_0718	COG0443	Heat shock 70 kDa protein
AMES_0724	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMES_0725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMES_0727	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMES_0736	COG1349	DNA-binding transcription factor activity
AMES_0737	COG1070	Carbohydrate kinase
AMES_0738	COG3842	ATPase activity
AMES_0739	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMES_0741	COG0802	atpase or kinase
AMES_0743	COG0825	malonyl-CoA metabolic process
AMES_0743	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMES_0744	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_0746	COG0456	acetyltransferase
AMES_0747	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMES_0748	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AMES_0752	COG1215	transferase activity, transferring glycosyl groups
AMES_0754	COG2226	methyltransferase
AMES_0757	COG0798	PFAM Bile acid sodium symporter
AMES_0758	COG0640	Transcriptional regulator
AMES_0760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMES_0761	COG0459	protein refolding
AMES_0772	COG0516	GMP reductase activity
AMES_0775	COG0277	FAD linked oxidase domain protein
AMES_0776	COG1012	belongs to the aldehyde dehydrogenase family
AMES_0780	COG0519	Catalyzes the synthesis of GMP from XMP
AMES_0780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMES_0783	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_0786	COG0697	spore germination
AMES_0789	COG0583	DNA-binding transcription factor activity
AMES_0790	COG2815	serine threonine protein kinase
AMES_0790	COG0515	serine threonine protein kinase
AMES_0800	COG0045	succinate-CoA ligase (ADP-forming) activity
AMES_0805	COG0138	bifunctional purine biosynthesis protein purh
AMES_0814	COG0587	DNA-directed DNA polymerase activity
AMES_0817	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMES_0819	COG2814	Major facilitator Superfamily
AMES_0820	COG0640	Transcriptional regulator
AMES_0822	COG2814	Major facilitator Superfamily
AMES_0823	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMES_0828	COG2226	methyltransferase
AMES_0835	COG1234	tRNA 3'-trailer cleavage
AMES_0838	COG0180	Tryptophanyl-tRNA synthetase
AMES_0840	COG1295	ribonuclease BN
AMES_0843	COG1733	regulation of RNA biosynthetic process
AMES_0847	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMES_0850	COG2009	succinate dehydrogenase
AMES_0851	COG3345	alpha-galactosidase
AMES_0852	COG1082	Xylose isomerase domain protein TIM barrel
AMES_0860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMES_0861	COG2271	Major facilitator Superfamily
AMES_0865	COG1733	regulation of RNA biosynthetic process
AMES_0867	COG1063	alcohol dehydrogenase
AMES_0870	COG0395	ABC-type sugar transport system, permease component
AMES_0877	COG1012	belongs to the aldehyde dehydrogenase family
AMES_0878	COG1012	belongs to the aldehyde dehydrogenase family
AMES_0879	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMES_0887	COG0789	Transcriptional regulator
AMES_0888	COG0667	Aldo Keto reductase
AMES_0892	COG0475	glutathione-regulated potassium exporter activity
AMES_0893	COG0745	RESPONSE REGULATOR receiver
AMES_0894	COG2205	protein histidine kinase activity
AMES_0898	COG0402	S-adenosylhomocysteine deaminase activity
AMES_0903	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMES_0908	COG0515	serine threonine protein kinase
AMES_0914	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMES_0914	COG1473	amidohydrolase
AMES_0922	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMES_0923	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMES_0924	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMES_0931	COG4770	biotin carboxylase activity
AMES_0934	COG1301	dicarboxylic acid transport
AMES_0935	COG0424	maF-like protein
AMES_0936	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_0940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_0942	COG1846	Transcriptional regulator
AMES_0943	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMES_0946	COG4585	Histidine kinase
AMES_0949	COG1309	transcriptional regulator
AMES_0951	COG1733	regulation of RNA biosynthetic process
AMES_0954	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_0956	COG0583	DNA-binding transcription factor activity
AMES_0960	COG2226	methyltransferase
AMES_0963	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMES_0963	COG1902	pentaerythritol trinitrate reductase activity
AMES_0966	COG4585	Histidine kinase
AMES_0967	COG2197	response regulator
AMES_0968	COG3103	Sh3 type 3 domain protein
AMES_0968	COG0791	NLP P60 protein
AMES_0968	COG1388	LysM domain
AMES_0971	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMES_0974	COG3537	Alpha-1,2-mannosidase
AMES_0975	COG0483	inositol monophosphate 1-phosphatase activity
AMES_0977	COG2205	protein histidine kinase activity
AMES_0978	COG2197	response regulator
AMES_0979	COG2197	response regulator
AMES_0991	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_0995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMES_1000	COG1316	TRANSCRIPTIONal
AMES_1002	COG1316	TRANSCRIPTIONal
AMES_1008	COG0438	transferase activity, transferring glycosyl groups
AMES_1015	COG1725	Transcriptional regulator
AMES_1018	COG0778	Nitroreductase
AMES_1018	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AMES_1037	COG1611	Belongs to the LOG family
AMES_1040	COG1216	Glycosyl transferase, family 2
AMES_1045	COG1132	(ABC) transporter
AMES_1046	COG0463	Glycosyl transferase, family 2
AMES_1047	COG4988	ABC transporter
AMES_1048	COG1294	oxidase, subunit
AMES_1049	COG1271	oxidase subunit
AMES_1054	COG2818	Glycosylase
AMES_1055	COG1024	Enoyl-CoA hydratase
AMES_1057	COG0583	DNA-binding transcription factor activity
AMES_1058	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMES_1059	COG2814	Major facilitator Superfamily
AMES_1061	COG4122	O-methyltransferase activity
AMES_1062	COG1595	DNA-templated transcription, initiation
AMES_1064	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMES_1065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMES_1068	COG2239	Acts as a magnesium transporter
AMES_1071	COG0330	HflC and HflK could
AMES_1081	COG1309	transcriptional regulator
AMES_1083	COG2197	response regulator
AMES_1084	COG4585	Histidine kinase
AMES_1090	COG0598	Magnesium transport protein CorA
AMES_1096	COG0613	PHP domain protein
AMES_1097	COG2095	MarC family integral membrane protein
AMES_1102	COG0513	Belongs to the DEAD box helicase family
AMES_1108	COG2267	carboxylic ester hydrolase activity
AMES_1109	COG1309	transcriptional regulator
AMES_1110	COG2267	carboxylic ester hydrolase activity
AMES_1114	COG0243	molybdopterin cofactor binding
AMES_1115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMES_1117	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMES_1117	COG2146	nitrite reductase [NAD(P)H] activity
AMES_1118	COG2146	nitrite reductase [NAD(P)H] activity
AMES_1118	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMES_1123	COG2378	regulation of single-species biofilm formation
AMES_1135	COG0714	Associated with various cellular activities
AMES_1140	COG2321	neutral zinc metallopeptidase
AMES_1144	COG0612	Peptidase, M16
AMES_1148	COG1175	transmembrane transport
AMES_1149	COG0395	ABC-type sugar transport system, permease component
AMES_1150	COG1486	melibiose metabolic process
AMES_1153	COG0640	Transcriptional regulator
AMES_1156	COG3265	gluconokinase activity
AMES_1158	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMES_1165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMES_1167	COG0406	alpha-ribazole phosphatase activity
AMES_1167	COG0328	RNA-DNA hybrid ribonuclease activity
AMES_1168	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AMES_1187	COG1012	belongs to the aldehyde dehydrogenase family
AMES_1194	COG1012	belongs to the aldehyde dehydrogenase family
AMES_1195	COG3842	ATPase activity
AMES_1196	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMES_1197	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMES_1198	COG1177	transmembrane transport
AMES_1199	COG0596	Alpha beta hydrolase
AMES_1200	COG1968	undecaprenyl-diphosphatase activity
AMES_1202	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMES_1203	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMES_1203	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMES_1205	COG2318	DinB family
AMES_1207	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMES_1207	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMES_1209	COG0653	protein targeting
AMES_1213	COG0174	glutamine synthetase
AMES_1214	COG0154	amidase activity
AMES_1215	COG1522	sequence-specific DNA binding
AMES_1217	COG0519	Catalyzes the synthesis of GMP from XMP
AMES_1217	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMES_1220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMES_1222	COG0174	glutamine synthetase
AMES_1233	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMES_1238	COG3480	Lon protease (S16) C-terminal proteolytic domain
AMES_1239	COG1615	UPF0182 protein
AMES_1243	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMES_1244	COG2884	Cell division ATP-binding protein ftsE
AMES_1245	COG2177	Part of the ABC transporter FtsEX involved in
AMES_1246	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMES_1250	COG2197	response regulator
AMES_1252	COG4585	Histidine kinase
AMES_1254	COG3706	GGDEF domain
AMES_1257	COG2986	histidine ammonia-lyase
AMES_1258	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMES_1260	COG0402	S-adenosylhomocysteine deaminase activity
AMES_1261	COG1228	amidohydrolase
AMES_1263	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_1269	COG4585	Histidine kinase
AMES_1275	COG1131	(ABC) transporter
AMES_1276	COG1643	Atp-dependent helicase
AMES_1277	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMES_1281	COG3883	PFAM NLP P60 protein
AMES_1281	COG0791	NLP P60 protein
AMES_1283	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_1286	COG2318	DinB family
AMES_1287	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_1289	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMES_1290	COG0187	DNA topoisomerase II activity
AMES_1299	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_1300	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_1301	COG1129	ABC transporter
AMES_1302	COG1879	ABC-type sugar transport system periplasmic component
AMES_1303	COG1609	Transcriptional regulator
AMES_1304	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMES_1306	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_1310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMES_1316	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMES_1322	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_1324	COG0017	Asparaginyl-tRNA synthetase
AMES_1328	COG0596	Alpha beta hydrolase
AMES_1333	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMES_1335	COG1486	melibiose metabolic process
AMES_1336	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_1337	COG1053	succinate dehydrogenase
AMES_1338	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMES_1340	COG0596	Alpha beta hydrolase
AMES_1357	COG0697	spore germination
AMES_1358	COG1846	Transcriptional regulator
AMES_1365	COG3629	intracellular signal transduction
AMES_1365	COG3903	Transcriptional regulator
AMES_1367	COG2211	Major facilitator Superfamily
AMES_1368	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMES_1369	COG0411	ABC transporter
AMES_1370	COG0410	ABC transporter
AMES_1374	COG1309	transcriptional regulator
AMES_1380	COG1136	(ABC) transporter
AMES_1390	COG0477	Major facilitator Superfamily
AMES_1394	COG3387	PFAM Glycoside hydrolase 15-related
AMES_1395	COG1063	alcohol dehydrogenase
AMES_1399	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_1409	COG3209	COG3209 Rhs family protein
AMES_1416	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_1416	COG0604	alcohol dehydrogenase
AMES_1416	COG3321	synthase
AMES_1422	COG2018	Roadblock/LC7 domain
AMES_1427	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_1428	COG0583	DNA-binding transcription factor activity
AMES_1429	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_1430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_1438	COG0667	Aldo Keto reductase
AMES_1440	COG1595	DNA-templated transcription, initiation
AMES_1444	COG3903	Transcriptional regulator
AMES_1444	COG3629	intracellular signal transduction
AMES_1446	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AMES_1452	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMES_1453	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_1461	COG1234	tRNA 3'-trailer cleavage
AMES_1463	COG3852	Histidine kinase
AMES_1464	COG2272	Belongs to the type-B carboxylesterase lipase family
AMES_1474	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMES_1490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMES_1491	COG0765	amino acid transport
AMES_1492	COG1126	abc transporter atp-binding protein
AMES_1493	COG2964	Protein conserved in bacteria
AMES_1496	COG0596	Alpha beta hydrolase
AMES_1497	COG1131	(ABC) transporter
AMES_1503	COG2186	Transcriptional regulator
AMES_1504	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_1505	COG1129	ABC transporter
AMES_1509	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_1509	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_1510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_1513	COG1879	ABC-type sugar transport system periplasmic component
AMES_1517	COG3629	intracellular signal transduction
AMES_1517	COG3903	Transcriptional regulator
AMES_1519	COG3540	Alkaline phosphatase
AMES_1521	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AMES_1523	COG3408	Glycogen debranching enzyme
AMES_1523	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AMES_1524	COG1940	carbohydrate kinase activity
AMES_1528	COG4221	oxidoreductase activity
AMES_1529	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMES_1533	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMES_1536	COG0513	Belongs to the DEAD box helicase family
AMES_1541	COG2183	response to ionizing radiation
AMES_1544	COG2072	flavoprotein involved in K transport
AMES_1553	COG2030	dehydratase
AMES_1553	COG1012	belongs to the aldehyde dehydrogenase family
AMES_1554	COG3396	Phenylacetate-CoA oxygenase
AMES_1555	COG3460	Phenylacetate-CoA oxygenase
AMES_1556	COG3396	Phenylacetate-CoA oxygenase
AMES_1557	COG2151	metal-sulfur cluster biosynthetic enzyme
AMES_1559	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMES_1561	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMES_1568	COG0183	Belongs to the thiolase family
AMES_1571	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_1572	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMES_1573	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AMES_1574	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMES_1576	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMES_1578	COG3279	Response regulator of the LytR AlgR family
AMES_1579	COG3275	phosphorelay sensor kinase activity
AMES_1581	COG1879	ABC-type sugar transport system periplasmic component
AMES_1582	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_1585	COG1609	Transcriptional regulator
AMES_1586	COG3537	Alpha-1,2-mannosidase
AMES_1587	COG3537	Alpha-1,2-mannosidase
AMES_1589	COG1846	Transcriptional regulator
AMES_1594	COG0058	SHG alpha-glucan phosphorylase activity
AMES_1599	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_1602	COG1119	ATPase activity
AMES_1603	COG1024	Enoyl-CoA hydratase
AMES_1604	COG2226	methyltransferase
AMES_1608	COG3979	chitinase
AMES_1610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_1617	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_1618	COG0667	Aldo Keto reductase
AMES_1619	COG0791	NLP P60 protein
AMES_1619	COG3883	PFAM NLP P60 protein
AMES_1620	COG1957	nucleoside hydrolase
AMES_1621	COG0110	maltose O-acetyltransferase activity
AMES_1635	COG3250	beta-galactosidase activity
AMES_1636	COG0386	Belongs to the glutathione peroxidase family
AMES_1638	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMES_1639	COG1307	EDD domain protein, DegV family
AMES_1642	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMES_1646	COG2197	response regulator
AMES_1649	COG0482	sulfurtransferase activity
AMES_1653	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMES_1657	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMES_1660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMES_1661	COG0154	amidase activity
AMES_1662	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMES_1667	COG0673	inositol 2-dehydrogenase activity
AMES_1669	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMES_1671	COG0129	dihydroxy-acid dehydratase activity
AMES_1674	COG0440	acetolactate synthase activity
AMES_1675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMES_1683	COG1404	Belongs to the peptidase S8 family
AMES_1684	COG0473	3-isopropylmalate dehydrogenase activity
AMES_1685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMES_1686	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMES_1690	COG3903	Transcriptional regulator
AMES_1690	COG3629	intracellular signal transduction
AMES_1700	COG0776	regulation of translation
AMES_1702	COG0420	3'-5' exonuclease activity
AMES_1703	COG0419	ATPase involved in DNA repair
AMES_1710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMES_1711	COG0066	3-isopropylmalate dehydratase activity
AMES_1713	COG3903	Transcriptional regulator
AMES_1713	COG3629	intracellular signal transduction
AMES_1718	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMES_1720	COG0252	asparaginase activity
AMES_1722	COG1477	protein flavinylation
AMES_1725	COG0745	RESPONSE REGULATOR receiver
AMES_1727	COG2205	protein histidine kinase activity
AMES_1728	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_1733	COG3345	alpha-galactosidase
AMES_1735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMES_1736	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMES_1738	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMES_1739	COG1461	Dihydroxyacetone kinase
AMES_1745	COG1404	Belongs to the peptidase S8 family
AMES_1746	COG5433	transposase activity
AMES_1748	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AMES_1762	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMES_1767	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMES_1769	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_1770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_1772	COG0542	response to heat
AMES_1773	COG2319	Wd-40 repeat
AMES_1773	COG4249	Peptidase C14 caspase catalytic subunit p20
AMES_1774	COG3973	AAA domain
AMES_1775	COG0742	ribosomal rna small subunit methyltransferase
AMES_1776	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMES_1782	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMES_1783	COG0571	ribonuclease III activity
AMES_1785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMES_1789	COG3386	PFAM SMP-30 Gluconolaconase
AMES_1795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMES_1796	COG1012	belongs to the aldehyde dehydrogenase family
AMES_1800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMES_1800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMES_1801	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMES_1802	COG0509	glycine decarboxylation via glycine cleavage system
AMES_1803	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMES_1804	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMES_1805	COG1760	l-serine dehydratase
AMES_1806	COG2442	InterPro IPR007367
AMES_1808	COG2186	Transcriptional regulator
AMES_1809	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMES_1811	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_1816	COG0789	Transcriptional regulator
AMES_1818	COG2814	Major facilitator Superfamily
AMES_1820	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMES_1821	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_1822	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_1824	COG1129	ABC transporter
AMES_1825	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_1826	COG2186	Transcriptional regulator
AMES_1835	COG1929	Belongs to the glycerate kinase type-1 family
AMES_1836	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMES_1838	COG1940	carbohydrate kinase activity
AMES_1839	COG1653	transport
AMES_1841	COG0395	ABC-type sugar transport system, permease component
AMES_1842	COG3345	alpha-galactosidase
AMES_1843	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMES_1844	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMES_1845	COG0183	Belongs to the thiolase family
AMES_1846	COG3485	protocatechuate 3,4-dioxygenase
AMES_1847	COG3485	protocatechuate 3,4-dioxygenase
AMES_1848	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMES_1850	COG1414	Transcriptional regulator
AMES_1851	COG0746	molybdenum cofactor guanylyltransferase activity
AMES_1852	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMES_1860	COG3706	GGDEF domain
AMES_1862	COG0667	Aldo Keto reductase
AMES_1866	COG3962	Belongs to the TPP enzyme family
AMES_1868	COG3718	enzyme involved in inositol metabolism
AMES_1870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMES_1874	COG1082	Xylose isomerase domain protein TIM barrel
AMES_1876	COG0673	inositol 2-dehydrogenase activity
AMES_1877	COG0367	asparagine synthase
AMES_1878	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMES_1879	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMES_1880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMES_1887	COG1254	Belongs to the acylphosphatase family
AMES_1890	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMES_1891	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMES_1895	COG1414	Transcriptional regulator
AMES_1903	COG3835	regulator
AMES_1907	COG3345	alpha-galactosidase
AMES_1908	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMES_1909	COG1309	transcriptional regulator
AMES_1915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMES_1916	COG4266	Belongs to the allantoicase family
AMES_1917	COG1832	CoA-binding protein
AMES_1923	COG1595	DNA-templated transcription, initiation
AMES_1927	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMES_1931	COG3706	GGDEF domain
AMES_1932	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_1933	COG1309	transcriptional regulator
AMES_1935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMES_1937	COG1132	(ABC) transporter
AMES_1942	COG0228	four-way junction DNA binding
AMES_1946	COG0336	Belongs to the RNA methyltransferase TrmD family
AMES_1947	COG0335	large ribosomal subunit rRNA binding
AMES_1948	COG0681	Belongs to the peptidase S26 family
AMES_1949	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMES_1951	COG0792	nuclease activity
AMES_1952	COG0606	chelatase, subunit chli
AMES_1956	COG1191	sigma factor activity
AMES_1958	COG0052	Belongs to the universal ribosomal protein uS2 family
AMES_1959	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMES_1960	COG0528	UMP kinase activity
AMES_1961	COG0233	cytoplasmic translational termination
AMES_1964	COG1695	Transcriptional regulator
AMES_1966	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMES_1967	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMES_1968	COG1120	ATPase activity
AMES_1969	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AMES_1971	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMES_1972	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMES_1982	COG0402	S-adenosylhomocysteine deaminase activity
AMES_1985	COG0402	S-adenosylhomocysteine deaminase activity
AMES_1993	COG0789	Transcriptional regulator
AMES_1997	COG3795	YCII-related domain
AMES_2001	COG1476	TRANSCRIPTIONal
AMES_2003	COG3795	YCII-related domain
AMES_2004	COG4941	Belongs to the sigma-70 factor family
AMES_2007	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMES_2010	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_2015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMES_2018	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMES_2020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMES_2022	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMES_2028	COG0456	acetyltransferase
AMES_2028	COG0454	-acetyltransferase
AMES_2035	COG2186	Transcriptional regulator
AMES_2042	COG0513	Belongs to the DEAD box helicase family
AMES_2049	COG0583	DNA-binding transcription factor activity
AMES_2051	COG3022	response to hydroperoxide
AMES_2052	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMES_2059	COG0442	prolyl-tRNA aminoacylation
AMES_2061	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMES_2071	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMES_2071	COG1017	nitric oxide dioxygenase activity
AMES_2073	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMES_2074	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMES_2075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMES_2084	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMES_2088	COG4152	abc transporter atp-binding protein
AMES_2089	COG1668	transmembrane transport
AMES_2091	COG1620	l-lactate permease
AMES_2092	COG3201	nicotinamide mononucleotide transporter
AMES_2095	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_2096	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AMES_2115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMES_2120	COG0477	Major facilitator Superfamily
AMES_2124	COG1960	acyl-CoA dehydrogenase activity
AMES_2125	COG1104	cysteine desulfurase activity
AMES_2129	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMES_2132	COG1113	amino acid transport
AMES_2133	COG2186	Transcriptional regulator
AMES_2134	COG0587	DNA-directed DNA polymerase activity
AMES_2135	COG0477	Major facilitator Superfamily
AMES_2139	COG0586	Pfam SNARE associated Golgi protein
AMES_2140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMES_2143	COG1309	transcriptional regulator
AMES_2145	COG0321	lipoyl(octanoyl) transferase activity
AMES_2147	COG1090	epimerase
AMES_2149	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMES_2159	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMES_2162	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMES_2162	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMES_2164	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMES_2165	COG0667	Aldo Keto reductase
AMES_2171	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMES_2178	COG1845	cytochrome c oxidase, subunit III
AMES_2179	COG2010	Cytochrome c
AMES_2181	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMES_2188	COG0438	transferase activity, transferring glycosyl groups
AMES_2190	COG2124	cytochrome p450
AMES_2191	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMES_2192	COG0659	secondary active sulfate transmembrane transporter activity
AMES_2193	COG0659	secondary active sulfate transmembrane transporter activity
AMES_2194	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMES_2197	COG0501	Belongs to the peptidase M48B family
AMES_2198	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMES_2200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AMES_2201	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AMES_2202	COG0157	Belongs to the NadC ModD family
AMES_2203	COG1404	Belongs to the peptidase S8 family
AMES_2211	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_2214	COG1674	ftsk spoiiie
AMES_2219	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMES_2221	COG5520	Belongs to the glycosyl hydrolase 30 family
AMES_2224	COG4566	intracellular signal transduction
AMES_2225	COG2197	response regulator
AMES_2227	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMES_2230	COG0131	Imidazoleglycerol-phosphate dehydratase
AMES_2232	COG2267	carboxylic ester hydrolase activity
AMES_2233	COG2409	Drug exporters of the RND superfamily
AMES_2234	COG1309	transcriptional regulator
AMES_2235	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AMES_2237	COG3959	Transketolase, thiamine diphosphate binding domain
AMES_2238	COG3958	Transketolase
AMES_2241	COG1960	acyl-CoA dehydrogenase activity
AMES_2243	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMES_2245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMES_2256	COG0107	imidazoleglycerol-phosphate synthase activity
AMES_2258	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMES_2265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMES_2267	COG0134	indole-3-glycerol-phosphate synthase activity
AMES_2268	COG0133	tryptophan synthase activity
AMES_2269	COG0159	tryptophan synthase activity
AMES_2270	COG0789	Transcriptional regulator
AMES_2274	COG0174	glutamine synthetase
AMES_2277	COG1473	amidohydrolase
AMES_2278	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMES_2280	COG0067	glutamate synthase
AMES_2280	COG0070	glutamate synthase
AMES_2280	COG0069	glutamate synthase activity
AMES_2284	COG0596	Alpha beta hydrolase
AMES_2285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMES_2288	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_2290	COG2268	Band 7 protein
AMES_2292	COG0515	serine threonine protein kinase
AMES_2292	COG2815	serine threonine protein kinase
AMES_2309	COG0242	peptide deformylase activity
AMES_2310	COG1201	RNA secondary structure unwinding
AMES_2311	COG1349	DNA-binding transcription factor activity
AMES_2313	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMES_2317	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMES_2318	COG2137	regulation of response to DNA damage stimulus
AMES_2322	COG0800	Aldolase
AMES_2326	COG1053	succinate dehydrogenase
AMES_2332	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_2333	COG0765	amino acid transport
AMES_2334	COG0765	amino acid transport
AMES_2335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMES_2336	COG1126	abc transporter atp-binding protein
AMES_2337	COG0745	RESPONSE REGULATOR receiver
AMES_2339	COG3850	Histidine kinase
AMES_2339	COG0642	Histidine kinase
AMES_2340	COG1733	regulation of RNA biosynthetic process
AMES_2353	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMES_2356	COG1196	nuclear chromosome segregation
AMES_2357	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMES_2359	COG0525	valine-tRNA ligase activity
AMES_2362	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMES_2366	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMES_2367	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMES_2371	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMES_2372	COG1505	serine-type exopeptidase activity
AMES_2380	COG2936	dipeptidyl-peptidase activity
AMES_2381	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AMES_2383	COG2197	response regulator
AMES_2384	COG4585	Histidine kinase
AMES_2387	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMES_2388	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AMES_2391	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMES_2393	COG1960	acyl-CoA dehydrogenase activity
AMES_2395	COG1960	acyl-CoA dehydrogenase activity
AMES_2397	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_2399	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMES_2400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMES_2410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_2413	COG1609	Transcriptional regulator
AMES_2416	COG0395	ABC-type sugar transport system, permease component
AMES_2417	COG2723	6-phospho-beta-galactosidase activity
AMES_2422	COG0003	Pfam Anion-transporting ATPase
AMES_2424	COG1940	carbohydrate kinase activity
AMES_2426	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMES_2432	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMES_2439	COG0640	Transcriptional regulator
AMES_2443	COG1946	Acyl-CoA thioesterase
AMES_2447	COG2197	response regulator
AMES_2448	COG1012	belongs to the aldehyde dehydrogenase family
AMES_2451	COG1960	acyl-CoA dehydrogenase activity
AMES_2452	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_2457	COG1566	PFAM secretion protein HlyD family protein
AMES_2460	COG1309	transcriptional regulator
AMES_2461	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMES_2464	COG2018	Roadblock/LC7 domain
AMES_2471	COG1703	isobutyryl-CoA mutase activity
AMES_2471	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMES_2471	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMES_2472	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_2473	COG1309	transcriptional regulator
AMES_2474	COG1960	acyl-CoA dehydrogenase activity
AMES_2475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMES_2478	COG0748	coenzyme F420 binding
AMES_2479	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_2481	COG1960	acyl-CoA dehydrogenase activity
AMES_2482	COG1960	acyl-CoA dehydrogenase activity
AMES_2483	COG2030	dehydratase
AMES_2487	COG0196	riboflavin kinase activity
AMES_2494	COG1960	acyl-CoA dehydrogenase activity
AMES_2495	COG2267	carboxylic ester hydrolase activity
AMES_2496	COG0346	lactoylglutathione lyase activity
AMES_2497	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMES_2502	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMES_2506	COG0583	DNA-binding transcription factor activity
AMES_2508	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMES_2520	COG1228	amidohydrolase
AMES_2521	COG0596	Alpha beta hydrolase
AMES_2522	COG0183	Belongs to the thiolase family
AMES_2524	COG2124	cytochrome p450
AMES_2526	COG1295	ribonuclease BN
AMES_2532	COG2070	2-Nitropropane dioxygenase
AMES_2535	COG2188	Transcriptional regulator
AMES_2539	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMES_2539	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AMES_2541	COG1490	D-aminoacyl-tRNA deacylase activity
AMES_2542	COG2890	protein-(glutamine-N5) methyltransferase activity
AMES_2543	COG1473	amidohydrolase
AMES_2546	COG2313	pseudouridylate synthase activity
AMES_2551	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMES_2554	COG4213	ABC transporter substrate-binding protein
AMES_2556	COG4214	carbohydrate transport
AMES_2561	COG0531	amino acid
AMES_2568	COG0366	Alpha amylase catalytic
AMES_2569	COG0366	Alpha amylase catalytic
AMES_2571	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMES_2574	COG1940	carbohydrate kinase activity
AMES_2575	COG0483	inositol monophosphate 1-phosphatase activity
AMES_2579	COG0756	dUTP diphosphatase activity
AMES_2585	COG0569	domain protein
AMES_2586	COG0531	amino acid
AMES_2587	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMES_2590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMES_2592	COG1012	belongs to the aldehyde dehydrogenase family
AMES_2593	COG0028	Belongs to the TPP enzyme family
AMES_2597	COG0745	RESPONSE REGULATOR receiver
AMES_2598	COG2205	protein histidine kinase activity
AMES_2601	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_2601	COG1024	Enoyl-CoA hydratase
AMES_2603	COG0183	Belongs to the thiolase family
AMES_2610	COG0531	amino acid
AMES_2613	COG2197	response regulator
AMES_2615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMES_2618	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_2620	COG3220	belongs to the UPF0276 family
AMES_2623	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMES_2629	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_2630	COG0539	negative regulation of cytoplasmic translation
AMES_2632	COG2508	Transcriptional regulator
AMES_2632	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMES_2633	COG1012	belongs to the aldehyde dehydrogenase family
AMES_2634	COG0506	proline dehydrogenase activity
AMES_2635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMES_2637	COG3795	YCII-related domain
AMES_2639	COG4941	Belongs to the sigma-70 factor family
AMES_2641	COG1793	dna ligase
AMES_2646	COG1302	Protein conserved in bacteria
AMES_2648	COG1595	DNA-templated transcription, initiation
AMES_2655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMES_2656	COG0640	Transcriptional regulator
AMES_2658	COG2326	polyphosphate kinase activity
AMES_2661	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMES_2662	COG1993	acr, cog1993
AMES_2663	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMES_2669	COG1672	PFAM Archaeal ATPase
AMES_2669	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMES_2673	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMES_2678	COG2124	cytochrome p450
AMES_2682	COG2084	Dehydrogenase
AMES_2685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMES_2687	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMES_2688	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMES_2689	COG1309	transcriptional regulator
AMES_2690	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMES_2692	COG1073	alpha beta
AMES_2694	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMES_2696	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMES_2697	COG1263	PTS System
AMES_2697	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMES_2699	COG1263	PTS System
AMES_2699	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMES_2700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMES_2700	COG2190	(PTS) system
AMES_2700	COG1263	PTS System
AMES_2705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMES_2706	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMES_2707	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMES_2708	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMES_2709	COG0346	lactoylglutathione lyase activity
AMES_2712	COG0006	proline dipeptidase activity
AMES_2713	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMES_2714	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMES_2718	COG0540	Belongs to the ATCase OTCase family
AMES_2721	COG0505	Belongs to the CarA family
AMES_2722	COG0419	ATPase involved in DNA repair
AMES_2725	COG0284	orotidine-5'-phosphate decarboxylase activity
AMES_2727	COG0194	GDP metabolic process
AMES_2728	COG1758	RNA polymerase activity
AMES_2730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMES_2735	COG0405	Gamma-glutamyltransferase
AMES_2736	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMES_2741	COG2197	response regulator
AMES_2742	COG4585	Histidine kinase
AMES_2745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMES_2745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMES_2746	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMES_2750	COG0322	excinuclease ABC activity
AMES_2751	COG1660	Displays ATPase and GTPase activities
AMES_2753	COG1481	regulation of sporulation
AMES_2754	COG0463	Glycosyl transferase, family 2
AMES_2759	COG3250	beta-galactosidase activity
AMES_2760	COG0408	coproporphyrinogen oxidase activity
AMES_2767	COG1280	lysine exporter protein (LysE YggA)
AMES_2770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMES_2771	COG0126	phosphoglycerate kinase activity
AMES_2772	COG0149	triose-phosphate isomerase activity
AMES_2776	COG0363	glucosamine-6-phosphate deaminase activity
AMES_2779	COG0166	Belongs to the GPI family
AMES_2780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMES_2782	COG0109	protoheme IX farnesyltransferase activity
AMES_2803	COG0396	ATPase activity
AMES_2806	COG2151	metal-sulfur cluster biosynthetic enzyme
AMES_2808	COG1742	UPF0060 membrane protein
AMES_2810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMES_2812	COG4585	Histidine kinase
AMES_2814	COG2226	methyltransferase
AMES_2822	COG0457	Tetratricopeptide repeat
AMES_2837	COG1132	(ABC) transporter
AMES_2839	COG4821	SIS domain
AMES_2841	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMES_2842	COG1316	TRANSCRIPTIONal
AMES_2844	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMES_2845	COG3300	MHYT domain
AMES_2845	COG5001	Diguanylate cyclase
AMES_2848	COG1051	belongs to the nudix hydrolase family
AMES_2850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMES_2850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMES_2852	COG1024	Enoyl-CoA hydratase
AMES_2857	COG1960	acyl-CoA dehydrogenase activity
AMES_2858	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMES_2861	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_2866	COG3469	chitinase activity
AMES_2874	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMES_2876	COG3693	PFAM glycoside hydrolase, family 10
AMES_2880	COG1309	transcriptional regulator
AMES_2881	COG0789	Transcriptional regulator
AMES_2884	COG2319	Wd-40 repeat
AMES_2884	COG4249	Peptidase C14 caspase catalytic subunit p20
AMES_2887	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_2900	COG2197	response regulator
AMES_2913	COG0300	oxidoreductase activity
AMES_2915	COG1846	Transcriptional regulator
AMES_2918	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMES_2921	COG1595	DNA-templated transcription, initiation
AMES_2925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMES_2926	COG1799	cell septum assembly
AMES_2928	COG3599	regulation of cell shape
AMES_2930	COG0640	Transcriptional regulator
AMES_2931	COG0477	Major facilitator Superfamily
AMES_2932	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMES_2934	COG0640	Transcriptional regulator
AMES_2935	COG3263	regulation of cellular component size
AMES_2936	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMES_2938	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMES_2943	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_2945	COG0248	Ppx GppA phosphatase
AMES_2952	COG1846	Transcriptional regulator
AMES_2952	COG1940	carbohydrate kinase activity
AMES_2955	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AMES_2960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMES_2960	COG2010	Cytochrome c
AMES_2965	COG1309	transcriptional regulator
AMES_2966	COG4221	oxidoreductase activity
AMES_2967	COG0667	Aldo Keto reductase
AMES_2968	COG0542	response to heat
AMES_2969	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMES_2972	COG0514	ATP-dependent DNA helicase (RecQ)
AMES_2974	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_2981	COG2205	protein histidine kinase activity
AMES_2982	COG0745	RESPONSE REGULATOR receiver
AMES_2985	COG0076	glutamate decarboxylase activity
AMES_2995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMES_2997	COG1131	(ABC) transporter
AMES_3001	COG0604	alcohol dehydrogenase
AMES_3003	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AMES_3005	COG4585	Histidine kinase
AMES_3007	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMES_3008	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMES_3009	COG2080	2 iron, 2 sulfur cluster binding
AMES_3014	COG2188	Transcriptional regulator
AMES_3016	COG1063	alcohol dehydrogenase
AMES_3019	COG2172	sigma factor antagonist activity
AMES_3020	COG1366	Belongs to the anti-sigma-factor antagonist family
AMES_3021	COG1366	Belongs to the anti-sigma-factor antagonist family
AMES_3026	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3027	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMES_3029	COG3546	catalase activity
AMES_3031	COG0702	epimerase
AMES_3032	COG1733	regulation of RNA biosynthetic process
AMES_3036	COG1609	Transcriptional regulator
AMES_3038	COG1175	transmembrane transport
AMES_3039	COG0395	ABC-type sugar transport system, permease component
AMES_3043	COG0667	Aldo Keto reductase
AMES_3044	COG0667	Aldo Keto reductase
AMES_3047	COG2378	regulation of single-species biofilm formation
AMES_3049	COG1691	(AIR) carboxylase
AMES_3050	COG3875	lactate racemase activity
AMES_3051	COG3618	amidohydrolase
AMES_3052	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMES_3053	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_3056	COG1129	ABC transporter
AMES_3064	COG1609	Transcriptional regulator
AMES_3065	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3069	COG3251	PFAM MbtH domain protein
AMES_3073	COG2124	cytochrome p450
AMES_3077	COG0604	alcohol dehydrogenase
AMES_3081	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMES_3092	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3096	COG3250	beta-galactosidase activity
AMES_3098	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3099	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3101	COG1309	transcriptional regulator
AMES_3104	COG1960	acyl-CoA dehydrogenase activity
AMES_3105	COG1960	acyl-CoA dehydrogenase activity
AMES_3110	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_3113	COG0395	ABC-type sugar transport system, permease component
AMES_3114	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMES_3115	COG0515	serine threonine protein kinase
AMES_3122	COG2814	Major facilitator Superfamily
AMES_3124	COG5002	protein histidine kinase activity
AMES_3125	COG0745	RESPONSE REGULATOR receiver
AMES_3128	COG1131	(ABC) transporter
AMES_3132	COG1309	transcriptional regulator
AMES_3137	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMES_3138	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_3140	COG1595	DNA-templated transcription, initiation
AMES_3144	COG0596	Alpha beta hydrolase
AMES_3146	COG0477	Major facilitator Superfamily
AMES_3155	COG0366	Alpha amylase catalytic
AMES_3159	COG1175	transmembrane transport
AMES_3162	COG1349	DNA-binding transcription factor activity
AMES_3164	COG1609	Transcriptional regulator
AMES_3165	COG0515	serine threonine protein kinase
AMES_3165	COG2815	serine threonine protein kinase
AMES_3166	COG0515	serine threonine protein kinase
AMES_3166	COG2815	serine threonine protein kinase
AMES_3169	COG0437	4 iron, 4 sulfur cluster binding
AMES_3171	COG2271	Major facilitator Superfamily
AMES_3174	COG2318	DinB family
AMES_3180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMES_3182	COG0583	DNA-binding transcription factor activity
AMES_3183	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_3185	COG1053	succinate dehydrogenase
AMES_3186	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMES_3193	COG3511	phospholipase C
AMES_3200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMES_3202	COG3938	Belongs to the proline racemase family
AMES_3203	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_3203	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_3204	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_3206	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMES_3207	COG0395	ABC-type sugar transport system, permease component
AMES_3208	COG1175	transmembrane transport
AMES_3218	COG0628	permease
AMES_3219	COG3507	Belongs to the glycosyl hydrolase 43 family
AMES_3220	COG1793	dna ligase
AMES_3220	COG3285	dna ligase
AMES_3223	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMES_3224	COG2226	methyltransferase
AMES_3231	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_3232	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMES_3233	COG1024	Enoyl-CoA hydratase
AMES_3236	COG1012	belongs to the aldehyde dehydrogenase family
AMES_3250	COG3507	Belongs to the glycosyl hydrolase 43 family
AMES_3264	COG1309	transcriptional regulator
AMES_3265	COG1595	DNA-templated transcription, initiation
AMES_3268	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3269	COG0028	Belongs to the TPP enzyme family
AMES_3273	COG2018	Roadblock/LC7 domain
AMES_3277	COG2188	Transcriptional regulator
AMES_3278	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AMES_3279	COG0395	ABC-type sugar transport system, permease component
AMES_3280	COG1175	transmembrane transport
AMES_3283	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMES_3290	COG3706	GGDEF domain
AMES_3290	COG0745	RESPONSE REGULATOR receiver
AMES_3291	COG1609	Transcriptional regulator
AMES_3297	COG3591	Belongs to the peptidase S1B family
AMES_3302	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMES_3307	COG2267	carboxylic ester hydrolase activity
AMES_3315	COG2357	RelA SpoT domain protein
AMES_3319	COG1280	lysine exporter protein (LysE YggA)
AMES_3320	COG0484	heat shock protein binding
AMES_3321	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMES_3326	COG2409	Drug exporters of the RND superfamily
AMES_3328	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMES_3338	COG1024	Enoyl-CoA hydratase
AMES_3342	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_3343	COG0183	Belongs to the thiolase family
AMES_3345	COG1960	acyl-CoA dehydrogenase activity
AMES_3346	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3347	COG1024	Enoyl-CoA hydratase
AMES_3348	COG1960	acyl-CoA dehydrogenase activity
AMES_3349	COG1960	acyl-CoA dehydrogenase activity
AMES_3351	COG1960	acyl-CoA dehydrogenase activity
AMES_3353	COG1802	Transcriptional regulator
AMES_3354	COG3591	Belongs to the peptidase S1B family
AMES_3354	COG1864	DNA RNA non-specific endonuclease
AMES_3357	COG1063	alcohol dehydrogenase
AMES_3358	COG2267	carboxylic ester hydrolase activity
AMES_3362	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMES_3363	COG1309	transcriptional regulator
AMES_3367	COG3345	alpha-galactosidase
AMES_3369	COG1175	transmembrane transport
AMES_3370	COG0395	ABC-type sugar transport system, permease component
AMES_3377	COG0477	Major facilitator Superfamily
AMES_3379	COG1940	carbohydrate kinase activity
AMES_3380	COG0531	amino acid
AMES_3381	COG3250	beta-galactosidase activity
AMES_3382	COG1940	carbohydrate kinase activity
AMES_3384	COG1609	Transcriptional regulator
AMES_3387	COG2124	cytochrome p450
AMES_3395	COG1846	Transcriptional regulator
AMES_3397	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_3406	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3412	COG0702	epimerase
AMES_3417	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMES_3420	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_3424	COG0601	transmembrane transport
AMES_3425	COG0444	Belongs to the ABC transporter superfamily
AMES_3426	COG4608	Belongs to the ABC transporter superfamily
AMES_3428	COG0477	Major facilitator Superfamily
AMES_3433	COG0477	Major facilitator Superfamily
AMES_3435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMES_3439	COG3507	Belongs to the glycosyl hydrolase 43 family
AMES_3442	COG1231	oxidoreductase activity
AMES_3444	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMES_3444	COG0235	Class ii aldolase
AMES_3447	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3448	COG0701	Predicted permease
AMES_3453	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3455	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3457	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3459	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMES_3466	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMES_3472	COG0501	Belongs to the peptidase M48B family
AMES_3479	COG0475	glutathione-regulated potassium exporter activity
AMES_3479	COG0569	domain protein
AMES_3486	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMES_3487	COG4279	zinc finger
AMES_3495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_3500	COG0069	glutamate synthase activity
AMES_3501	COG0745	RESPONSE REGULATOR receiver
AMES_3502	COG5002	protein histidine kinase activity
AMES_3505	COG0577	efflux transmembrane transporter activity
AMES_3505	COG1136	(ABC) transporter
AMES_3506	COG1136	(ABC) transporter
AMES_3506	COG0577	efflux transmembrane transporter activity
AMES_3509	COG2814	Major facilitator Superfamily
AMES_3510	COG0596	Alpha beta hydrolase
AMES_3512	COG4585	Histidine kinase
AMES_3518	COG4585	Histidine kinase
AMES_3526	COG4221	oxidoreductase activity
AMES_3527	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AMES_3541	COG0745	RESPONSE REGULATOR receiver
AMES_3542	COG2205	protein histidine kinase activity
AMES_3546	COG0726	polysaccharide deacetylase
AMES_3568	COG4221	oxidoreductase activity
AMES_3569	COG4249	Peptidase C14 caspase catalytic subunit p20
AMES_3569	COG2319	Wd-40 repeat
AMES_3582	COG2197	response regulator
AMES_3583	COG0736	holo-[acyl-carrier-protein] synthase activity
AMES_3587	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMES_3598	COG1834	amidinotransferase
AMES_3600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMES_3601	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMES_3602	COG2080	2 iron, 2 sulfur cluster binding
AMES_3604	COG3345	alpha-galactosidase
AMES_3611	COG1309	transcriptional regulator
AMES_3617	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3618	COG0583	DNA-binding transcription factor activity
AMES_3632	COG0583	DNA-binding transcription factor activity
AMES_3649	COG2205	protein histidine kinase activity
AMES_3655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_3663	COG1522	sequence-specific DNA binding
AMES_3676	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMES_3678	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMES_3679	COG2080	2 iron, 2 sulfur cluster binding
AMES_3684	COG0631	protein serine/threonine phosphatase activity
AMES_3693	COG3509	depolymerase
AMES_3697	COG0601	transmembrane transport
AMES_3699	COG4608	Belongs to the ABC transporter superfamily
AMES_3701	COG1609	Transcriptional regulator
AMES_3702	COG4124	Belongs to the glycosyl hydrolase 26 family
AMES_3704	COG1846	Transcriptional regulator
AMES_3704	COG1940	carbohydrate kinase activity
AMES_3706	COG1960	acyl-CoA dehydrogenase activity
AMES_3707	COG2207	Transcriptional regulator
AMES_3721	COG0745	RESPONSE REGULATOR receiver
AMES_3722	COG2205	protein histidine kinase activity
AMES_3723	COG2755	lipolytic protein G-D-S-L family
AMES_3723	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMES_3729	COG2267	carboxylic ester hydrolase activity
AMES_3730	COG2226	methyltransferase
AMES_3732	COG0640	Transcriptional regulator
AMES_3740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AMES_3741	COG0375	protein maturation
AMES_3743	COG0409	Hydrogenase expression formation protein
AMES_3752	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMES_3754	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMES_3761	COG3629	intracellular signal transduction
AMES_3761	COG3903	Transcriptional regulator
AMES_3762	COG0596	Alpha beta hydrolase
AMES_3763	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_3763	COG1024	Enoyl-CoA hydratase
AMES_3764	COG1733	regulation of RNA biosynthetic process
AMES_3770	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3771	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_3772	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3773	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3779	COG0411	ABC transporter
AMES_3781	COG1024	Enoyl-CoA hydratase
AMES_3782	COG1960	acyl-CoA dehydrogenase activity
AMES_3783	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3784	COG1946	Acyl-CoA thioesterase
AMES_3786	COG1024	Enoyl-CoA hydratase
AMES_3787	COG1960	acyl-CoA dehydrogenase activity
AMES_3788	COG1012	belongs to the aldehyde dehydrogenase family
AMES_3790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_3791	COG0183	Belongs to the thiolase family
AMES_3799	COG1946	Acyl-CoA thioesterase
AMES_3803	COG1960	acyl-CoA dehydrogenase activity
AMES_3807	COG0183	Belongs to the thiolase family
AMES_3810	COG0183	Belongs to the thiolase family
AMES_3811	COG1024	Enoyl-CoA hydratase
AMES_3814	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3817	COG1024	Enoyl-CoA hydratase
AMES_3819	COG1960	acyl-CoA dehydrogenase activity
AMES_3820	COG1960	acyl-CoA dehydrogenase activity
AMES_3821	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3826	COG1960	acyl-CoA dehydrogenase activity
AMES_3829	COG1012	belongs to the aldehyde dehydrogenase family
AMES_3830	COG1960	acyl-CoA dehydrogenase activity
AMES_3831	COG1960	acyl-CoA dehydrogenase activity
AMES_3832	COG1024	Enoyl-CoA hydratase
AMES_3833	COG2188	Transcriptional regulator
AMES_3834	COG0300	oxidoreductase activity
AMES_3835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMES_3841	COG1309	transcriptional regulator
AMES_3843	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMES_3844	COG3903	Transcriptional regulator
AMES_3844	COG3629	intracellular signal transduction
AMES_3848	COG1017	nitric oxide dioxygenase activity
AMES_3848	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMES_3849	COG1846	Transcriptional regulator
AMES_3849	COG1940	carbohydrate kinase activity
AMES_3851	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMES_3853	COG0531	amino acid
AMES_3854	COG3387	PFAM Glycoside hydrolase 15-related
AMES_3855	COG2814	Major facilitator Superfamily
AMES_3857	COG2197	response regulator
AMES_3864	COG0628	permease
AMES_3867	COG1486	melibiose metabolic process
AMES_3868	COG0395	ABC-type sugar transport system, permease component
AMES_3872	COG1349	DNA-binding transcription factor activity
AMES_3873	COG2222	sugar isomerase
AMES_3876	COG1105	Belongs to the carbohydrate kinase PfkB family
AMES_3889	COG0596	Alpha beta hydrolase
AMES_3891	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMES_3891	COG1024	Enoyl-CoA hydratase
AMES_3893	COG3903	Transcriptional regulator
AMES_3893	COG3629	intracellular signal transduction
AMES_3894	COG1132	(ABC) transporter
AMES_3899	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3903	COG4221	oxidoreductase activity
AMES_3904	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_3905	COG0395	ABC-type sugar transport system, permease component
AMES_3906	COG3833	ABC-type maltose transport systems, permease component
AMES_3913	COG2124	cytochrome p450
AMES_3914	COG2175	clavaminate synthase activity
AMES_3915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_3915	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3915	COG4221	oxidoreductase activity
AMES_3915	COG3321	synthase
AMES_3916	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_3917	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3926	COG1940	carbohydrate kinase activity
AMES_3927	COG1846	Transcriptional regulator
AMES_3927	COG1940	carbohydrate kinase activity
AMES_3928	COG1129	ABC transporter
AMES_3929	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_3931	COG0673	inositol 2-dehydrogenase activity
AMES_3933	COG0604	alcohol dehydrogenase
AMES_3948	COG1064	alcohol dehydrogenase
AMES_3949	COG1309	transcriptional regulator
AMES_3950	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3953	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMES_3954	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_3958	COG2508	Transcriptional regulator
AMES_3959	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMES_3961	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMES_3962	COG0463	Glycosyl transferase, family 2
AMES_3964	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_3966	COG3629	intracellular signal transduction
AMES_3967	COG0583	DNA-binding transcription factor activity
AMES_3969	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3970	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3972	COG1846	Transcriptional regulator
AMES_3973	COG3903	Transcriptional regulator
AMES_3973	COG3629	intracellular signal transduction
AMES_3974	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMES_3977	COG2197	response regulator
AMES_3979	COG0577	efflux transmembrane transporter activity
AMES_3979	COG1136	(ABC) transporter
AMES_3985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMES_3991	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMES_3994	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_3996	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMES_3997	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMES_3998	COG3629	intracellular signal transduction
AMES_3998	COG3903	Transcriptional regulator
AMES_3999	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMES_4003	COG3509	depolymerase
AMES_4004	COG2205	protein histidine kinase activity
AMES_4005	COG0745	RESPONSE REGULATOR receiver
AMES_4006	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMES_4008	COG0583	DNA-binding transcription factor activity
AMES_4012	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_4019	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMES_4037	COG0395	ABC-type sugar transport system, permease component
AMES_4040	COG1609	Transcriptional regulator
AMES_4046	COG0653	protein targeting
AMES_4055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_4057	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMES_4061	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMES_4062	COG1012	belongs to the aldehyde dehydrogenase family
AMES_4063	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMES_4070	COG3661	Belongs to the glycosyl hydrolase 67 family
AMES_4073	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_4082	COG2201	protein-glutamate methylesterase activity
AMES_4083	COG2201	protein-glutamate methylesterase activity
AMES_4087	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMES_4096	COG0477	Major facilitator Superfamily
AMES_4099	COG2318	DinB family
AMES_4100	COG1793	dna ligase
AMES_4106	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AMES_4108	COG2814	Major facilitator Superfamily
AMES_4110	COG2855	membrane
AMES_4111	COG0583	DNA-binding transcription factor activity
AMES_4118	COG0439	Biotin carboxylase
AMES_4126	COG0477	Major facilitator Superfamily
AMES_4131	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_4135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMES_4140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMES_4147	COG1793	dna ligase
AMES_4147	COG3285	dna ligase
AMES_4152	COG2267	carboxylic ester hydrolase activity
AMES_4160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMES_4162	COG3634	alkyl hydroperoxide reductase activity
AMES_4166	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMES_4178	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMES_4181	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMES_4183	COG2890	protein-(glutamine-N5) methyltransferase activity
AMES_4187	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMES_4188	COG2124	cytochrome p450
AMES_4190	COG2201	protein-glutamate methylesterase activity
AMES_4193	COG2815	serine threonine protein kinase
AMES_4193	COG0515	serine threonine protein kinase
AMES_4195	COG0326	Molecular chaperone. Has ATPase activity
AMES_4197	COG3794	PFAM blue (type 1) copper domain protein
AMES_4210	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_4213	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMES_4218	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMES_4220	COG0300	oxidoreductase activity
AMES_4221	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMES_4221	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMES_4222	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMES_4223	COG2192	nodulation
AMES_4224	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMES_4227	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AMES_4227	COG0463	Glycosyl transferase, family 2
AMES_4228	COG0297	glycogen (starch) synthase activity
AMES_4237	COG1295	ribonuclease BN
AMES_4237	COG1959	2 iron, 2 sulfur cluster binding
AMES_4242	COG0723	plastoquinol--plastocyanin reductase activity
AMES_4242	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMES_4243	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMES_4244	COG2890	protein-(glutamine-N5) methyltransferase activity
AMES_4247	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMES_4249	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMES_4251	COG1982	Orn Lys Arg decarboxylase major
AMES_4255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMES_4260	COG0596	Alpha beta hydrolase
AMES_4265	COG3835	regulator
AMES_4270	COG3284	Transcriptional regulator
AMES_4279	COG0459	protein refolding
AMES_4283	COG0596	Alpha beta hydrolase
AMES_4285	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_4286	COG0435	Glutathione S-transferase
AMES_4288	COG2353	YceI-like domain
AMES_4289	COG1309	transcriptional regulator
AMES_4292	COG0395	ABC-type sugar transport system, permease component
AMES_4295	COG1609	Transcriptional regulator
AMES_4296	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_4298	COG2124	cytochrome p450
AMES_4300	COG1716	ATPase activity
AMES_4300	COG5001	Diguanylate cyclase
AMES_4303	COG2181	nitrate reductase activity
AMES_4303	COG0247	lactate metabolic process
AMES_4304	COG1716	ATPase activity
AMES_4305	COG0477	Major facilitator Superfamily
AMES_4308	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMES_4313	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_4315	COG4991	sh3 domain protein
AMES_4330	COG0302	gtp cyclohydrolase
AMES_4333	COG1609	Transcriptional regulator
AMES_4337	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_4340	COG1686	Belongs to the peptidase S11 family
AMES_4342	COG1609	Transcriptional regulator
AMES_4343	COG1879	ABC-type sugar transport system periplasmic component
AMES_4345	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_4346	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_4350	COG2160	L-arabinose isomerase activity
AMES_4352	COG1129	ABC transporter
AMES_4353	COG4214	carbohydrate transport
AMES_4355	COG1609	Transcriptional regulator
AMES_4357	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMES_4358	COG1414	Transcriptional regulator
AMES_4360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMES_4361	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMES_4363	COG0137	argininosuccinate synthase activity
AMES_4372	COG0277	FAD linked oxidase domain protein
AMES_4373	COG1609	Transcriptional regulator
AMES_4375	COG1653	transport
AMES_4376	COG1175	transmembrane transport
AMES_4377	COG0395	ABC-type sugar transport system, permease component
AMES_4379	COG0673	inositol 2-dehydrogenase activity
AMES_4380	COG0673	inositol 2-dehydrogenase activity
AMES_4382	COG3866	Pectate lyase
AMES_4387	COG3629	intracellular signal transduction
AMES_4387	COG3903	Transcriptional regulator
AMES_4391	COG0589	response to stress
AMES_4392	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMES_4404	COG1090	epimerase
AMES_4409	COG0297	glycogen (starch) synthase activity
AMES_4414	COG3250	beta-galactosidase activity
AMES_4417	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMES_4426	COG0477	Major facilitator Superfamily
AMES_4427	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_4427	COG3321	synthase
AMES_4428	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_4431	COG0300	oxidoreductase activity
AMES_4432	COG1819	glycosyl
AMES_4435	COG3285	dna ligase
AMES_4435	COG1793	dna ligase
AMES_4436	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMES_4439	COG2267	carboxylic ester hydrolase activity
AMES_4442	COG3903	Transcriptional regulator
AMES_4442	COG3629	intracellular signal transduction
AMES_4443	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMES_4445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMES_4445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMES_4445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMES_4448	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMES_4452	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_4453	COG1609	Transcriptional regulator
AMES_4456	COG0395	ABC-type sugar transport system, permease component
AMES_4458	COG1609	Transcriptional regulator
AMES_4462	COG1278	Cold shock
AMES_4463	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMES_4473	COG0387	Pfam Sodium calcium exchanger
AMES_4474	COG0583	DNA-binding transcription factor activity
AMES_4475	COG0028	Belongs to the TPP enzyme family
AMES_4483	COG1609	Transcriptional regulator
AMES_4484	COG1129	ABC transporter
AMES_4485	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_4486	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_4488	COG3254	rhamnose metabolic process
AMES_4490	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_4490	COG3347	Dehydrogenase
AMES_4492	COG1070	Carbohydrate kinase
AMES_4493	COG2197	response regulator
AMES_4494	COG4585	Histidine kinase
AMES_4497	COG3250	beta-galactosidase activity
AMES_4508	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMES_4509	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMES_4513	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMES_4515	COG0045	succinate-CoA ligase (ADP-forming) activity
AMES_4517	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_4518	COG1042	CoA-binding domain protein
AMES_4518	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMES_4518	COG0045	succinate-CoA ligase (ADP-forming) activity
AMES_4519	COG2223	nitrite transmembrane transporter activity
AMES_4520	COG1802	Transcriptional regulator
AMES_4521	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMES_4522	COG3383	formate dehydrogenase (NAD+) activity
AMES_4523	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMES_4524	COG1034	ATP synthesis coupled electron transport
AMES_4525	COG3622	Belongs to the hyi family
AMES_4526	COG2084	Dehydrogenase
AMES_4527	COG3960	tartronate-semialdehyde synthase activity
AMES_4530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMES_4531	COG0590	tRNA wobble adenosine to inosine editing
AMES_4532	COG2252	PERMEase
AMES_4534	COG1929	Belongs to the glycerate kinase type-1 family
AMES_4545	COG2066	Belongs to the glutaminase family
AMES_4548	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMES_4551	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMES_4552	COG0596	Alpha beta hydrolase
AMES_4554	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_4557	COG1793	dna ligase
AMES_4557	COG3285	dna ligase
AMES_4558	COG0183	Belongs to the thiolase family
AMES_4559	COG1733	regulation of RNA biosynthetic process
AMES_4566	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_4567	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_4568	COG1609	Transcriptional regulator
AMES_4570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMES_4571	COG2267	carboxylic ester hydrolase activity
AMES_4578	COG0667	Aldo Keto reductase
AMES_4579	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_4580	COG1968	undecaprenyl-diphosphatase activity
AMES_4582	COG0339	signal peptide processing
AMES_4583	COG0740	serine-type endopeptidase activity
AMES_4584	COG0039	L-malate dehydrogenase activity
AMES_4591	COG3537	Alpha-1,2-mannosidase
AMES_4599	COG0747	negative chemotaxis
AMES_4600	COG0601	transmembrane transport
AMES_4602	COG4172	Belongs to the ABC transporter superfamily
AMES_4605	COG1619	proteins homologs of microcin C7 resistance protein MccF
AMES_4606	COG1506	peptidase
AMES_4606	COG4946	Tricorn protease homolog
AMES_4606	COG0823	Involved in the tonB-independent uptake of proteins
AMES_4618	COG0477	Major facilitator Superfamily
AMES_4622	COG0640	Transcriptional regulator
AMES_4631	COG4941	Belongs to the sigma-70 factor family
AMES_4644	COG4941	Belongs to the sigma-70 factor family
AMES_4647	COG2124	cytochrome p450
AMES_4650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMES_4653	COG1309	transcriptional regulator
AMES_4654	COG1960	acyl-CoA dehydrogenase activity
AMES_4656	COG1309	transcriptional regulator
AMES_4658	COG1396	sequence-specific DNA binding
AMES_4661	COG0640	Transcriptional regulator
AMES_4663	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AMES_4668	COG1435	thymidine kinase activity
AMES_4670	COG0494	nUDIX hydrolase
AMES_4671	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMES_4673	COG0463	Glycosyl transferase, family 2
AMES_4675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMES_4679	COG4977	sequence-specific DNA binding
AMES_4680	COG1733	regulation of RNA biosynthetic process
AMES_4684	COG3903	Transcriptional regulator
AMES_4684	COG3629	intracellular signal transduction
AMES_4691	COG4865	methylaspartate mutase activity
AMES_4692	COG0017	Asparaginyl-tRNA synthetase
AMES_4693	COG0069	glutamate synthase activity
AMES_4696	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMES_4706	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_4711	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_4716	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_4728	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_4729	COG2186	Transcriptional regulator
AMES_4730	COG0395	ABC-type sugar transport system, permease component
AMES_4731	COG1175	transmembrane transport
AMES_4732	COG3293	Transposase
AMES_4736	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMES_4738	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMES_4739	COG4865	methylaspartate mutase activity
AMES_4741	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_4750	COG0789	Transcriptional regulator
AMES_4760	COG2124	cytochrome p450
AMES_4767	COG2197	response regulator
AMES_4768	COG2197	response regulator
AMES_4770	COG0823	Involved in the tonB-independent uptake of proteins
AMES_4791	COG0402	S-adenosylhomocysteine deaminase activity
AMES_4792	COG1414	Transcriptional regulator
AMES_4793	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_4795	COG3485	protocatechuate 3,4-dioxygenase
AMES_4799	COG3979	chitinase
AMES_4801	COG1136	(ABC) transporter
AMES_4805	COG4221	oxidoreductase activity
AMES_4807	COG0583	DNA-binding transcription factor activity
AMES_4808	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMES_4817	COG4552	Acetyltransferase involved in intracellular survival and related
AMES_4820	COG1597	lipid kinase activity
AMES_4823	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMES_4825	COG2378	regulation of single-species biofilm formation
AMES_4827	COG1733	regulation of RNA biosynthetic process
AMES_4830	COG4221	oxidoreductase activity
AMES_4831	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMES_4834	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMES_4835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMES_4842	COG0640	Transcriptional regulator
AMES_4845	COG0697	spore germination
AMES_4846	COG1222	aaa ATPase
AMES_4851	COG1994	Peptidase M50
AMES_4851	COG0517	IMP dehydrogenase activity
AMES_4854	COG1192	Involved in chromosome partitioning
AMES_4855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMES_4856	COG0140	phosphoribosyl-ATP diphosphatase activity
AMES_4859	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMES_4860	COG1410	methionine synthase
AMES_4860	COG0646	methionine synthase
AMES_4866	COG2814	Major facilitator Superfamily
AMES_4870	COG0488	(ABC) transporter
AMES_4871	COG0215	cysteine-tRNA ligase activity
AMES_4872	COG0789	Transcriptional regulator
AMES_4873	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMES_4874	COG4867	von Willebrand factor, type A
AMES_4881	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMES_4883	COG0477	Major facilitator Superfamily
AMES_4884	COG0745	RESPONSE REGULATOR receiver
AMES_4885	COG2205	protein histidine kinase activity
AMES_4888	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMES_4890	COG2304	oxidoreductase activity
AMES_4892	COG0714	Associated with various cellular activities
AMES_4893	COG0746	molybdenum cofactor guanylyltransferase activity
AMES_4894	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMES_4895	COG0791	NLP P60 protein
AMES_4895	COG3883	PFAM NLP P60 protein
AMES_4896	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMES_4897	COG1285	pathogenesis
AMES_4899	COG1309	transcriptional regulator
AMES_4902	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AMES_4904	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMES_4905	COG3572	ergothioneine biosynthetic process
AMES_4907	COG2267	carboxylic ester hydrolase activity
AMES_4908	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMES_4913	COG1309	transcriptional regulator
AMES_4921	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMES_4924	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMES_4924	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMES_4928	COG0789	Transcriptional regulator
AMES_4931	COG1716	ATPase activity
AMES_4937	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMES_4938	COG1024	Enoyl-CoA hydratase
AMES_4939	COG2267	carboxylic ester hydrolase activity
AMES_4940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMES_4940	COG1648	precorrin-2 dehydrogenase activity
AMES_4943	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMES_4944	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMES_4945	COG0254	rRNA binding
AMES_4953	COG2211	Major facilitator Superfamily
AMES_4954	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_4960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_4963	COG1116	anion transmembrane transporter activity
AMES_4964	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMES_4965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMES_4966	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMES_4970	COG1132	(ABC) transporter
AMES_4973	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMES_4975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMES_4976	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMES_4977	COG1120	ATPase activity
AMES_4978	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AMES_4986	COG0488	(ABC) transporter
AMES_4994	COG3293	Transposase
AMES_5007	COG3250	beta-galactosidase activity
AMES_5011	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_5013	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_5014	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMES_5016	COG1116	anion transmembrane transporter activity
AMES_5017	COG2205	protein histidine kinase activity
AMES_5018	COG0745	RESPONSE REGULATOR receiver
AMES_5024	COG1846	Transcriptional regulator
AMES_5025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMES_5027	COG0028	Belongs to the TPP enzyme family
AMES_5028	COG1073	alpha beta
AMES_5029	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5030	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMES_5032	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_5036	COG1129	ABC transporter
AMES_5037	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMES_5040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMES_5046	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMES_5047	COG0463	Glycosyl transferase, family 2
AMES_5054	COG4221	oxidoreductase activity
AMES_5057	COG1921	L-seryl-tRNASec selenium transferase activity
AMES_5058	COG0709	Synthesizes selenophosphate from selenide and ATP
AMES_5064	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMES_5065	COG2367	Beta-lactamase
AMES_5068	COG2267	carboxylic ester hydrolase activity
AMES_5075	COG0596	Alpha beta hydrolase
AMES_5077	COG1309	transcriptional regulator
AMES_5085	COG2409	Drug exporters of the RND superfamily
AMES_5089	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMES_5090	COG0019	diaminopimelate decarboxylase activity
AMES_5099	COG2201	protein-glutamate methylesterase activity
AMES_5100	COG4585	Histidine kinase
AMES_5102	COG2197	response regulator
AMES_5105	COG1324	tolerance protein
AMES_5116	COG2814	Major facilitator Superfamily
AMES_5123	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMES_5124	COG0667	Aldo Keto reductase
AMES_5129	COG5297	Belongs to the glycosyl hydrolase family 6
AMES_5130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMES_5131	COG4733	cellulase activity
AMES_5131	COG5297	Belongs to the glycosyl hydrolase family 6
AMES_5135	COG0395	ABC-type sugar transport system, permease component
AMES_5137	COG0129	dihydroxy-acid dehydratase activity
AMES_5140	COG1573	uracil-dna glycosylase
AMES_5141	COG1793	dna ligase
AMES_5141	COG3285	dna ligase
AMES_5143	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMES_5162	COG0583	DNA-binding transcription factor activity
AMES_5164	COG0019	diaminopimelate decarboxylase activity
AMES_5168	COG0477	Major facilitator Superfamily
AMES_5170	COG0456	acetyltransferase
AMES_5172	COG4104	PAAR repeat-containing protein
AMES_5172	COG3209	COG3209 Rhs family protein
AMES_5193	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMES_5199	COG0456	acetyltransferase
AMES_5200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMES_5203	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMES_5207	COG2018	Roadblock/LC7 domain
AMES_5208	COG2205	protein histidine kinase activity
AMES_5215	COG3629	intracellular signal transduction
AMES_5215	COG3903	Transcriptional regulator
AMES_5220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMES_5223	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_5223	COG1024	Enoyl-CoA hydratase
AMES_5230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMES_5231	COG0402	S-adenosylhomocysteine deaminase activity
AMES_5232	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMES_5233	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMES_5234	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMES_5235	COG1862	Preprotein translocase
AMES_5236	COG2255	four-way junction helicase activity
AMES_5237	COG0632	four-way junction helicase activity
AMES_5238	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMES_5241	COG0217	transcriptional regulatory protein
AMES_5242	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AMES_5245	COG1396	sequence-specific DNA binding
AMES_5246	COG0644	oxidoreductase
AMES_5247	COG1960	acyl-CoA dehydrogenase activity
AMES_5251	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AMES_5253	COG0277	FAD linked oxidase domain protein
AMES_5255	COG3608	succinylglutamate desuccinylase aspartoacylase
AMES_5255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMES_5259	COG0438	transferase activity, transferring glycosyl groups
AMES_5264	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMES_5265	COG0778	Nitroreductase
AMES_5269	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMES_5270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMES_5271	COG0701	Predicted permease
AMES_5274	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5276	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMES_5279	COG1473	amidohydrolase
AMES_5282	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMES_5286	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_5288	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_5301	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMES_5302	COG0395	ABC-type sugar transport system, permease component
AMES_5303	COG1175	transmembrane transport
AMES_5306	COG2072	flavoprotein involved in K transport
AMES_5309	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5318	COG2211	Major facilitator Superfamily
AMES_5319	COG1802	Transcriptional regulator
AMES_5327	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMES_5335	COG3483	tryptophan 2,3-dioxygenase activity
AMES_5338	COG2197	response regulator
AMES_5339	COG4585	Histidine kinase
AMES_5341	COG1131	(ABC) transporter
AMES_5343	COG3510	cephalosporin hydroxylase
AMES_5344	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_5346	COG1819	glycosyl
AMES_5348	COG1819	glycosyl
AMES_5356	COG3629	intracellular signal transduction
AMES_5357	COG1819	glycosyl
AMES_5358	COG3848	Pyruvate phosphate dikinase
AMES_5358	COG0574	Belongs to the PEP-utilizing enzyme family
AMES_5361	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5365	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5367	COG2867	negative regulation of translational initiation
AMES_5368	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMES_5369	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMES_5370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMES_5371	COG0662	Cupin 2, conserved barrel domain protein
AMES_5374	COG3104	oligopeptide transport
AMES_5375	COG2345	Transcriptional regulator
AMES_5376	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_5380	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5389	COG3209	COG3209 Rhs family protein
AMES_5395	COG0659	secondary active sulfate transmembrane transporter activity
AMES_5397	COG0589	response to stress
AMES_5401	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMES_5404	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMES_5405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMES_5405	COG0045	succinate-CoA ligase (ADP-forming) activity
AMES_5405	COG1042	CoA-binding domain protein
AMES_5409	COG1271	oxidase subunit
AMES_5410	COG1294	oxidase, subunit
AMES_5411	COG4988	ABC transporter
AMES_5412	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AMES_5414	COG2239	Acts as a magnesium transporter
AMES_5420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMES_5424	COG4585	Histidine kinase
AMES_5425	COG2197	response regulator
AMES_5429	COG4585	Histidine kinase
AMES_5430	COG2197	response regulator
AMES_5441	COG2197	response regulator
AMES_5448	COG0681	Belongs to the peptidase S26 family
AMES_5449	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5462	COG0405	Gamma-glutamyltransferase
AMES_5463	COG3706	GGDEF domain
AMES_5472	COG1216	Glycosyl transferase, family 2
AMES_5473	COG1215	transferase activity, transferring glycosyl groups
AMES_5475	COG1132	(ABC) transporter
AMES_5478	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_5479	COG0596	Alpha beta hydrolase
AMES_5490	COG2814	Major facilitator Superfamily
AMES_5492	COG3629	intracellular signal transduction
AMES_5492	COG3903	Transcriptional regulator
AMES_5506	COG0330	HflC and HflK could
AMES_5521	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMES_5532	COG0297	glycogen (starch) synthase activity
AMES_5537	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5538	COG1309	transcriptional regulator
AMES_5539	COG4941	Belongs to the sigma-70 factor family
AMES_5540	COG4941	Belongs to the sigma-70 factor family
AMES_5544	COG3250	beta-galactosidase activity
AMES_5545	COG0583	DNA-binding transcription factor activity
AMES_5552	COG0515	serine threonine protein kinase
AMES_5553	COG1595	DNA-templated transcription, initiation
AMES_5554	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMES_5563	COG0596	Alpha beta hydrolase
AMES_5564	COG0596	Alpha beta hydrolase
AMES_5566	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMES_5569	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMES_5569	COG1672	PFAM Archaeal ATPase
AMES_5570	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5575	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5581	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMES_5593	COG2205	protein histidine kinase activity
AMES_5594	COG0745	RESPONSE REGULATOR receiver
AMES_5595	COG1216	Glycosyl transferase, family 2
AMES_5596	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMES_5601	COG1609	Transcriptional regulator
AMES_5603	COG1309	transcriptional regulator
AMES_5614	COG4941	Belongs to the sigma-70 factor family
AMES_5618	COG1335	isochorismatase
AMES_5623	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_5625	COG1309	transcriptional regulator
AMES_5627	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AMES_5628	COG1414	Transcriptional regulator
AMES_5629	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5633	COG1278	Cold shock
AMES_5636	COG0300	oxidoreductase activity
AMES_5638	COG3795	YCII-related domain
AMES_5641	COG3263	regulation of cellular component size
AMES_5642	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMES_5644	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMES_5652	COG0745	RESPONSE REGULATOR receiver
AMES_5653	COG5000	phosphorelay sensor kinase activity
AMES_5653	COG5002	protein histidine kinase activity
AMES_5655	COG1733	regulation of RNA biosynthetic process
AMES_5657	COG1846	Transcriptional regulator
AMES_5658	COG0038	chloride channel
AMES_5665	COG0437	4 iron, 4 sulfur cluster binding
AMES_5672	COG2116	formate transmembrane transporter activity
AMES_5673	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AMES_5677	COG0531	amino acid
AMES_5678	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMES_5681	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMES_5682	COG2080	2 iron, 2 sulfur cluster binding
AMES_5684	COG0667	Aldo Keto reductase
AMES_5687	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5696	COG1609	Transcriptional regulator
AMES_5697	COG1609	Transcriptional regulator
AMES_5701	COG1609	Transcriptional regulator
AMES_5705	COG2207	Transcriptional regulator
AMES_5705	COG1917	Cupin 2, conserved barrel domain protein
AMES_5728	COG3293	Transposase
AMES_5732	COG1857	crispr-associated protein
AMES_5748	COG4733	cellulase activity
AMES_5748	COG5297	Belongs to the glycosyl hydrolase family 6
AMES_5753	COG0154	amidase activity
AMES_5754	COG0640	Transcriptional regulator
AMES_5755	COG0789	Transcriptional regulator
AMES_5760	COG0673	inositol 2-dehydrogenase activity
AMES_5766	COG1653	transport
AMES_5772	COG3842	ATPase activity
AMES_5774	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMES_5775	COG0028	Belongs to the TPP enzyme family
AMES_5778	COG2197	response regulator
AMES_5781	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMES_5783	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMES_5785	COG0702	epimerase
AMES_5787	COG0583	DNA-binding transcription factor activity
AMES_5790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMES_5801	COG0300	oxidoreductase activity
AMES_5802	COG4221	oxidoreductase activity
AMES_5803	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMES_5804	COG0406	alpha-ribazole phosphatase activity
AMES_5804	COG0328	RNA-DNA hybrid ribonuclease activity
AMES_5815	COG2318	DinB family
AMES_5816	COG0667	Aldo Keto reductase
AMES_5820	COG2267	carboxylic ester hydrolase activity
AMES_5821	COG3629	intracellular signal transduction
AMES_5821	COG3903	Transcriptional regulator
AMES_5833	COG4974	Belongs to the 'phage' integrase family
AMES_5834	COG1012	belongs to the aldehyde dehydrogenase family
AMES_5844	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMES_5852	COG2815	serine threonine protein kinase
AMES_5852	COG0515	serine threonine protein kinase
AMES_5855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMES_5860	COG3511	phospholipase C
AMES_5870	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_5879	COG0714	Associated with various cellular activities
AMES_5881	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AMES_5882	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMES_5884	COG1733	regulation of RNA biosynthetic process
AMES_5886	COG5492	domain, Protein
AMES_5889	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_5890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMES_5892	COG1414	Transcriptional regulator
AMES_5893	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMES_5897	COG0726	polysaccharide deacetylase
AMES_5913	COG1160	GTP binding
AMES_5919	COG2936	dipeptidyl-peptidase activity
AMES_5920	COG0475	glutathione-regulated potassium exporter activity
AMES_5921	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMES_5923	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMES_5930	COG0504	CTP synthase activity
AMES_5932	COG1802	Transcriptional regulator
AMES_5933	COG1953	Uracil, thiamine, allantoin
AMES_5940	COG1063	alcohol dehydrogenase
AMES_5943	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMES_5946	COG0647	UMP catabolic process
AMES_5948	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMES_5949	COG2094	Belongs to the DNA glycosylase MPG family
AMES_5952	COG0165	Argininosuccinate lyase
AMES_5954	COG0137	argininosuccinate synthase activity
AMES_5955	COG1438	arginine binding
AMES_5956	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMES_5957	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMES_5958	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMES_5959	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMES_5960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMES_5963	COG0596	Alpha beta hydrolase
AMES_5965	COG0072	phenylalanine-tRNA ligase activity
AMES_5965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMES_5966	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMES_5968	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMES_5969	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMES_5970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMES_5979	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMES_5980	COG2610	gluconate transmembrane transporter activity
AMES_5987	COG4565	transcriptional regulatory protein
AMES_5988	COG3290	protein histidine kinase activity
AMES_5989	COG1301	dicarboxylic acid transport
AMES_5999	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMES_6004	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMES_6005	COG0328	RNA-DNA hybrid ribonuclease activity
AMES_6006	COG3012	SEC-C Motif Domain Protein
AMES_6008	COG3250	beta-galactosidase activity
AMES_6009	COG2272	Belongs to the type-B carboxylesterase lipase family
AMES_6013	COG0406	alpha-ribazole phosphatase activity
AMES_6016	COG1609	Transcriptional regulator
AMES_6020	COG0823	Involved in the tonB-independent uptake of proteins
AMES_6020	COG1506	peptidase
AMES_6020	COG4946	Tricorn protease homolog
AMES_6022	COG1131	(ABC) transporter
AMES_6027	COG1024	Enoyl-CoA hydratase
AMES_6034	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMES_6034	COG0237	dephospho-CoA kinase activity
AMES_6039	COG0539	negative regulation of cytoplasmic translation
AMES_6040	COG2226	methyltransferase
AMES_6044	COG1511	domain protein
AMES_6045	COG2207	Transcriptional regulator
AMES_6046	COG1309	transcriptional regulator
AMES_6047	COG0604	alcohol dehydrogenase
AMES_6053	COG0583	DNA-binding transcription factor activity
AMES_6055	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMES_6101	COG4585	Histidine kinase
AMES_6102	COG2197	response regulator
AMES_6106	COG2197	response regulator
AMES_6107	COG4585	Histidine kinase
AMES_6111	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMES_6112	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMES_6116	COG1454	alcohol dehydrogenase
AMES_6118	COG1012	belongs to the aldehyde dehydrogenase family
AMES_6122	COG0596	Alpha beta hydrolase
AMES_6126	COG4977	sequence-specific DNA binding
AMES_6127	COG0596	Alpha beta hydrolase
AMES_6129	COG0300	oxidoreductase activity
AMES_6137	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMES_6146	COG3251	PFAM MbtH domain protein
AMES_6158	COG2814	Major facilitator Superfamily
AMES_6160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMES_6161	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMES_6163	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMES_6164	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMES_6167	COG0768	penicillin binding
AMES_6169	COG0275	rRNA processing
AMES_6170	COG2001	Belongs to the MraZ family
AMES_6176	COG0714	Associated with various cellular activities
AMES_6178	COG1305	Transglutaminase-like
AMES_6182	COG1192	Involved in chromosome partitioning
AMES_6183	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMES_6184	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMES_6187	COG0167	dihydroorotate dehydrogenase activity
AMES_6190	COG1396	sequence-specific DNA binding
AMES_6191	COG1546	Belongs to the CinA family
AMES_6191	COG1058	Belongs to the CinA family
AMES_6193	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMES_6194	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AMES_6200	COG1674	ftsk spoiiie
AMES_6202	COG0655	NAD(P)H dehydrogenase (quinone) activity
AMES_6207	COG1113	amino acid transport
AMES_6208	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMES_6209	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMES_6217	COG3214	Protein conserved in bacteria
AMES_6225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMES_6226	COG0612	Peptidase, M16
AMES_6227	COG1185	polyribonucleotide nucleotidyltransferase activity
AMES_6228	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMES_6232	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMES_6237	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMES_6239	COG2268	Band 7 protein
AMES_6242	COG2226	methyltransferase
AMES_6249	COG0195	Participates in both transcription termination and antitermination
AMES_6250	COG0779	Required for maturation of 30S ribosomal subunits
AMES_6256	COG3226	Transcriptional regulator
AMES_6258	COG4585	Histidine kinase
AMES_6260	COG2197	response regulator
AMES_6261	COG1733	regulation of RNA biosynthetic process
AMES_6263	COG1309	transcriptional regulator
AMES_6264	COG2936	dipeptidyl-peptidase activity
AMES_6267	COG0745	RESPONSE REGULATOR receiver
AMES_6268	COG5002	protein histidine kinase activity
AMES_6270	COG3903	Transcriptional regulator
AMES_6270	COG3629	intracellular signal transduction
AMES_6274	COG0583	DNA-binding transcription factor activity
AMES_6275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_6276	COG1024	Enoyl-CoA hydratase
AMES_6278	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_6279	COG1960	acyl-CoA dehydrogenase activity
AMES_6280	COG1316	TRANSCRIPTIONal
AMES_6285	COG0583	DNA-binding transcription factor activity
AMES_6290	COG2124	cytochrome p450
AMES_6298	COG3629	intracellular signal transduction
AMES_6298	COG3903	Transcriptional regulator
AMES_6308	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMES_6316	COG1595	DNA-templated transcription, initiation
AMES_6321	COG3507	Belongs to the glycosyl hydrolase 43 family
AMES_6324	COG4941	Belongs to the sigma-70 factor family
AMES_6325	COG3795	YCII-related domain
AMES_6326	COG2267	carboxylic ester hydrolase activity
AMES_6327	COG1309	transcriptional regulator
AMES_6328	COG0604	alcohol dehydrogenase
AMES_6333	COG0443	Heat shock 70 kDa protein
AMES_6336	COG1228	amidohydrolase
AMES_6345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMES_6350	COG2197	response regulator
AMES_6356	COG2755	lipolytic protein G-D-S-L family
AMES_6356	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMES_6364	COG3629	intracellular signal transduction
AMES_6364	COG3903	Transcriptional regulator
AMES_6369	COG0667	Aldo Keto reductase
AMES_6375	COG1960	acyl-CoA dehydrogenase activity
AMES_6379	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_6381	COG0596	Alpha beta hydrolase
AMES_6382	COG2197	response regulator
AMES_6387	COG0477	Major facilitator Superfamily
AMES_6397	COG4585	Histidine kinase
AMES_6398	COG2197	response regulator
AMES_6401	COG0586	Pfam SNARE associated Golgi protein
AMES_6403	COG1968	undecaprenyl-diphosphatase activity
AMES_6411	COG4585	Histidine kinase
AMES_6412	COG2197	response regulator
AMES_6415	COG1309	transcriptional regulator
AMES_6417	COG0702	epimerase
AMES_6418	COG0702	epimerase
AMES_6423	COG2814	Major facilitator Superfamily
AMES_6428	COG4977	sequence-specific DNA binding
AMES_6439	COG1120	ATPase activity
AMES_6440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMES_6463	COG0243	molybdopterin cofactor binding
AMES_6471	COG0028	Belongs to the TPP enzyme family
AMES_6472	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_6473	COG0277	FAD linked oxidase domain protein
AMES_6473	COG0247	lactate metabolic process
AMES_6477	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMES_6478	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AMES_6480	COG1659	Linocin_M18 bacteriocin protein
AMES_6483	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AMES_6486	COG4106	trans-aconitate 2-methyltransferase activity
AMES_6490	COG1595	DNA-templated transcription, initiation
AMES_6492	COG0477	Major facilitator Superfamily
AMES_6496	COG2318	DinB family
AMES_6499	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AMES_6501	COG2197	response regulator
AMES_6502	COG4585	Histidine kinase
AMES_6504	COG1131	(ABC) transporter
AMES_6505	COG0423	glycine-tRNA ligase activity
AMES_6513	COG0701	Predicted permease
AMES_6515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMES_6516	COG1381	Involved in DNA repair and RecF pathway recombination
AMES_6522	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMES_6525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMES_6527	COG0537	adenosine 5'-monophosphoramidase activity
AMES_6529	COG0484	heat shock protein binding
AMES_6530	COG1420	regulation of RNA biosynthetic process
AMES_6534	COG0667	Aldo Keto reductase
AMES_6542	COG2205	protein histidine kinase activity
AMES_6543	COG0745	RESPONSE REGULATOR receiver
AMES_6544	COG1953	Uracil, thiamine, allantoin
AMES_6546	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMES_6564	COG0326	Molecular chaperone. Has ATPase activity
AMES_6567	COG1024	Enoyl-CoA hydratase
AMES_6568	COG2732	(Barnase) inhibitor
AMES_6569	COG4290	ribonuclease
AMES_6571	COG0604	alcohol dehydrogenase
AMES_6573	COG2070	2-Nitropropane dioxygenase
AMES_6574	COG0531	amino acid
AMES_6586	COG0268	Binds directly to 16S ribosomal RNA
AMES_6588	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMES_6590	COG2333	competence protein COMEC
AMES_6590	COG0658	competence protein
AMES_6592	COG1307	EDD domain protein, DegV family
AMES_6594	COG0406	alpha-ribazole phosphatase activity
AMES_6595	COG0799	negative regulation of ribosome biogenesis
AMES_6596	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMES_6598	COG0477	Major facilitator Superfamily
AMES_6599	COG0018	arginyl-trna synthetase
AMES_6603	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_6605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMES_6606	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMES_6607	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMES_6608	COG1530	ribonuclease E activity
AMES_6608	COG1530	ribonuclease E activity
AMES_6612	COG1131	(ABC) transporter
AMES_6615	COG0105	UTP biosynthetic process
AMES_6617	COG2366	antibiotic biosynthetic process
AMES_6619	COG0285	dihydrofolate synthase activity
AMES_6624	COG0583	DNA-binding transcription factor activity
AMES_6625	COG0525	valine-tRNA ligase activity
AMES_6627	COG1846	Transcriptional regulator
AMES_6628	COG0477	Major facilitator Superfamily
AMES_6631	COG1316	TRANSCRIPTIONal
AMES_6634	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMES_6640	COG0740	serine-type endopeptidase activity
AMES_6641	COG0740	serine-type endopeptidase activity
AMES_6642	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMES_6644	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMES_6646	COG2205	protein histidine kinase activity
AMES_6647	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMES_6658	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMES_6667	COG3537	Alpha-1,2-mannosidase
AMES_6668	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMES_6669	COG3559	Exporter of polyketide antibiotics
AMES_6670	COG1131	(ABC) transporter
AMES_6671	COG1309	transcriptional regulator
AMES_6673	COG1940	carbohydrate kinase activity
AMES_6677	COG2814	Major facilitator Superfamily
AMES_6683	COG0693	protein deglycase activity
AMES_6684	COG2208	phosphoserine phosphatase activity
AMES_6685	COG5002	protein histidine kinase activity
AMES_6685	COG0784	Response regulator, receiver
AMES_6687	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMES_6690	COG1396	sequence-specific DNA binding
AMES_6694	COG0583	DNA-binding transcription factor activity
AMES_6696	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_6698	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_6701	COG1733	regulation of RNA biosynthetic process
AMES_6702	COG3345	alpha-galactosidase
AMES_6707	COG0459	protein refolding
AMES_6709	COG0698	ribose 5-phosphate isomerase
AMES_6712	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMES_6715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AMES_6719	COG0668	transmembrane transport
AMES_6721	COG0366	Alpha amylase catalytic
AMES_6725	COG2902	Dehydrogenase
AMES_6728	COG3336	cytochrome c oxidase
AMES_6731	COG0738	Major facilitator superfamily
AMES_6733	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMES_6734	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMES_6738	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMES_6746	COG0477	Major facilitator Superfamily
AMES_6747	COG0596	Alpha beta hydrolase
AMES_6751	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMES_6755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMES_6764	COG2124	cytochrome p450
AMES_6771	COG1733	regulation of RNA biosynthetic process
AMES_6772	COG4941	Belongs to the sigma-70 factor family
AMES_6773	COG3795	YCII-related domain
AMES_6775	COG0009	L-threonylcarbamoyladenylate synthase
AMES_6778	COG2197	response regulator
AMES_6779	COG4977	sequence-specific DNA binding
AMES_6779	COG1917	Cupin 2, conserved barrel domain protein
AMES_6780	COG2197	response regulator
AMES_6781	COG4585	Histidine kinase
AMES_6784	COG1733	regulation of RNA biosynthetic process
AMES_6789	COG1937	Protein conserved in bacteria
AMES_6795	COG4221	oxidoreductase activity
AMES_6798	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMES_6807	COG0745	RESPONSE REGULATOR receiver
AMES_6808	COG2205	protein histidine kinase activity
AMES_6810	COG1609	Transcriptional regulator
AMES_6817	COG0367	asparagine synthase
AMES_6818	COG1940	carbohydrate kinase activity
AMES_6822	COG0583	DNA-binding transcription factor activity
AMES_6830	COG1609	Transcriptional regulator
AMES_6837	COG0531	amino acid
AMES_6838	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMES_6844	COG3835	regulator
AMES_6849	COG1021	2,3-dihydroxybenzoate-AMP ligase
AMES_6851	COG1733	regulation of RNA biosynthetic process
AMES_6853	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMES_6855	COG0583	DNA-binding transcription factor activity
AMES_6863	COG1024	Enoyl-CoA hydratase
AMES_6875	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_6878	COG1643	Atp-dependent helicase
AMES_6881	COG2072	flavoprotein involved in K transport
AMES_6882	COG3268	Saccharopine dehydrogenase
AMES_6885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMES_6885	COG1796	DNA polymerase
AMES_6887	COG1802	Transcriptional regulator
AMES_6892	COG3706	GGDEF domain
AMES_6894	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AMES_6897	COG4941	Belongs to the sigma-70 factor family
AMES_6901	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMES_6904	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_6906	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMES_6907	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMES_6908	COG0235	Class ii aldolase
AMES_6908	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMES_6911	COG1695	Transcriptional regulator
AMES_6913	COG3959	Transketolase, thiamine diphosphate binding domain
AMES_6914	COG1309	transcriptional regulator
AMES_6915	COG0277	FAD linked oxidase domain protein
AMES_6915	COG0247	lactate metabolic process
AMES_6917	COG2197	response regulator
AMES_6919	COG0410	ABC transporter
AMES_6921	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMES_6922	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMES_6925	COG3537	Alpha-1,2-mannosidase
AMES_6926	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMES_6927	COG1739	Uncharacterized protein family UPF0029
AMES_6928	COG0067	glutamate synthase
AMES_6928	COG0069	glutamate synthase activity
AMES_6928	COG0070	glutamate synthase
AMES_6930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMES_6936	COG1492	cobalamin metabolic process
AMES_6937	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMES_6939	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMES_6940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AMES_6942	COG2378	regulation of single-species biofilm formation
AMES_6944	COG1797	cobyrinic acid a,c-diamide synthase activity
AMES_6951	COG0778	Nitroreductase
AMES_6957	COG1131	(ABC) transporter
AMES_6960	COG1476	TRANSCRIPTIONal
AMES_6962	COG3469	chitinase activity
AMES_6966	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMES_6971	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMES_6973	COG0433	COG0433 Predicted ATPase
AMES_6974	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMES_6976	COG0477	Major facilitator Superfamily
AMES_7012	COG1960	acyl-CoA dehydrogenase activity
AMES_7014	COG0022	dehydrogenase e1 component
AMES_7015	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_7016	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7017	COG1024	Enoyl-CoA hydratase
AMES_7020	COG0477	Major facilitator Superfamily
AMES_7024	COG2186	Transcriptional regulator
AMES_7025	COG1012	belongs to the aldehyde dehydrogenase family
AMES_7026	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_7029	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7036	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMES_7038	COG1309	transcriptional regulator
AMES_7040	COG0604	alcohol dehydrogenase
AMES_7049	COG1960	acyl-CoA dehydrogenase activity
AMES_7050	COG1960	acyl-CoA dehydrogenase activity
AMES_7052	COG2186	Transcriptional regulator
AMES_7055	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7055	COG3321	synthase
AMES_7055	COG0604	alcohol dehydrogenase
AMES_7056	COG1960	acyl-CoA dehydrogenase activity
AMES_7057	COG1960	acyl-CoA dehydrogenase activity
AMES_7060	COG1024	Enoyl-CoA hydratase
AMES_7065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_7068	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7074	COG1414	Transcriptional regulator
AMES_7076	COG2267	carboxylic ester hydrolase activity
AMES_7079	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7080	COG0259	pyridoxamine-phosphate oxidase activity
AMES_7081	COG0183	Belongs to the thiolase family
AMES_7083	COG1024	Enoyl-CoA hydratase
AMES_7084	COG1960	acyl-CoA dehydrogenase activity
AMES_7088	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_7090	COG1024	Enoyl-CoA hydratase
AMES_7092	COG1024	Enoyl-CoA hydratase
AMES_7097	COG1024	Enoyl-CoA hydratase
AMES_7098	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMES_7101	COG1012	belongs to the aldehyde dehydrogenase family
AMES_7104	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMES_7111	COG1335	isochorismatase
AMES_7114	COG1309	transcriptional regulator
AMES_7116	COG0022	dehydrogenase e1 component
AMES_7122	COG1063	alcohol dehydrogenase
AMES_7124	COG4585	Histidine kinase
AMES_7125	COG2197	response regulator
AMES_7129	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_7130	COG2271	Major facilitator Superfamily
AMES_7136	COG0235	Class ii aldolase
AMES_7137	COG0477	Major facilitator Superfamily
AMES_7138	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMES_7144	COG0673	inositol 2-dehydrogenase activity
AMES_7145	COG2211	Major facilitator Superfamily
AMES_7146	COG1609	Transcriptional regulator
AMES_7147	COG1653	transport
AMES_7149	COG0395	ABC-type sugar transport system, permease component
AMES_7151	COG0596	Alpha beta hydrolase
AMES_7153	COG0596	Alpha beta hydrolase
AMES_7156	COG2084	Dehydrogenase
AMES_7158	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMES_7159	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMES_7161	COG0189	ligase activity
AMES_7164	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_7165	COG0625	glutathione transferase activity
AMES_7167	COG2271	Major facilitator Superfamily
AMES_7168	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMES_7170	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_7204	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMES_7212	COG2856	Zn peptidase
AMES_7218	COG0702	epimerase
AMES_7223	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMES_7224	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMES_7225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_7226	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7227	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMES_7227	COG2169	Transcriptional regulator
AMES_7245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMES_7253	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMES_7254	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMES_7258	COG1960	acyl-CoA dehydrogenase activity
AMES_7262	COG0154	amidase activity
AMES_7265	COG0583	DNA-binding transcription factor activity
AMES_7273	COG1131	(ABC) transporter
AMES_7275	COG3345	alpha-galactosidase
AMES_7284	COG0438	transferase activity, transferring glycosyl groups
AMES_7288	COG0297	glycogen (starch) synthase activity
AMES_7289	COG0438	transferase activity, transferring glycosyl groups
AMES_7292	COG0463	Glycosyl transferase, family 2
AMES_7299	COG3250	beta-galactosidase activity
AMES_7300	COG3401	FG-GAP repeat protein
AMES_7306	COG0395	ABC-type sugar transport system, permease component
AMES_7307	COG1175	transmembrane transport
AMES_7315	COG0596	Alpha beta hydrolase
AMES_7316	COG2770	Histidine kinase
AMES_7316	COG2208	phosphoserine phosphatase activity
AMES_7318	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMES_7319	COG2226	methyltransferase
AMES_7322	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMES_7330	COG0667	Aldo Keto reductase
AMES_7331	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_7335	COG0587	DNA-directed DNA polymerase activity
AMES_7336	COG4941	Belongs to the sigma-70 factor family
AMES_7337	COG3795	YCII-related domain
AMES_7339	COG1982	Orn Lys Arg decarboxylase major
AMES_7342	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMES_7344	COG1725	Transcriptional regulator
AMES_7345	COG1131	(ABC) transporter
AMES_7349	COG3509	depolymerase
AMES_7352	COG1528	Iron-storage protein
AMES_7357	COG2018	Roadblock/LC7 domain
AMES_7362	COG1764	response to oxidative stress
AMES_7364	COG2267	carboxylic ester hydrolase activity
AMES_7367	COG0667	Aldo Keto reductase
AMES_7368	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMES_7375	COG0395	ABC-type sugar transport system, permease component
AMES_7376	COG1175	transmembrane transport
AMES_7377	COG1609	Transcriptional regulator
AMES_7382	COG0604	alcohol dehydrogenase
AMES_7388	COG1595	DNA-templated transcription, initiation
AMES_7390	COG0129	dihydroxy-acid dehydratase activity
AMES_7391	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_7392	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMES_7403	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMES_7411	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMES_7412	COG2226	methyltransferase
AMES_7413	COG2508	Transcriptional regulator
AMES_7415	COG3655	Transcriptional regulator
AMES_7424	COG4981	capsule polysaccharide biosynthetic process
AMES_7429	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_7430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMES_7442	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMES_7445	COG3226	Transcriptional regulator
AMES_7457	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMES_7462	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_7465	COG0745	RESPONSE REGULATOR receiver
AMES_7467	COG5002	protein histidine kinase activity
AMES_7470	COG0515	serine threonine protein kinase
AMES_7470	COG2815	serine threonine protein kinase
AMES_7475	COG0640	Transcriptional regulator
AMES_7477	COG2837	iron assimilation
AMES_7478	COG3511	phospholipase C
AMES_7481	COG0784	Response regulator, receiver
AMES_7482	COG4251	negative regulation of phosphorylation
AMES_7483	COG0745	RESPONSE REGULATOR receiver
AMES_7499	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMES_7504	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMES_7519	COG1309	transcriptional regulator
AMES_7523	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AMES_7524	COG1309	transcriptional regulator
AMES_7528	COG3383	formate dehydrogenase (NAD+) activity
AMES_7529	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_7530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_7532	COG1733	regulation of RNA biosynthetic process
AMES_7539	COG2814	Major facilitator Superfamily
AMES_7546	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7551	COG0706	membrane insertase activity
AMES_7554	COG1408	metallophosphoesterase
AMES_7556	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMES_7558	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMES_7562	COG2018	Roadblock/LC7 domain
AMES_7565	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7569	COG3706	GGDEF domain
AMES_7571	COG1316	TRANSCRIPTIONal
AMES_7578	COG4977	sequence-specific DNA binding
AMES_7579	COG0667	Aldo Keto reductase
AMES_7580	COG2207	Transcriptional regulator
AMES_7585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMES_7587	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMES_7588	COG1234	tRNA 3'-trailer cleavage
AMES_7589	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMES_7591	COG1794	racemase activity, acting on amino acids and derivatives
AMES_7593	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMES_7597	COG3191	aminopeptidase activity
AMES_7601	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMES_7602	COG1335	isochorismatase
AMES_7603	COG0800	Aldolase
AMES_7605	COG1268	BioY protein
AMES_7611	COG0560	Phosphoserine phosphatase
AMES_7611	COG3830	Belongs to the UPF0237 family
AMES_7612	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMES_7613	COG2267	carboxylic ester hydrolase activity
AMES_7618	COG2801	Transposase and inactivated derivatives
AMES_7621	COG0626	cystathionine gamma-synthase activity
AMES_7622	COG1522	sequence-specific DNA binding
AMES_7624	COG1522	sequence-specific DNA binding
AMES_7631	COG2376	Dihydroxyacetone kinase
AMES_7637	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AMES_7639	COG1051	belongs to the nudix hydrolase family
AMES_7641	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AMES_7642	COG4977	sequence-specific DNA binding
AMES_7644	COG1335	isochorismatase
AMES_7647	COG1280	lysine exporter protein (LysE YggA)
AMES_7649	COG1280	lysine exporter protein (LysE YggA)
AMES_7650	COG0702	epimerase
AMES_7651	COG3631	Ketosteroid isomerase-related protein
AMES_7652	COG1309	transcriptional regulator
AMES_7654	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMES_7657	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMES_7658	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMES_7659	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMES_7660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMES_7661	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMES_7662	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMES_7663	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMES_7664	COG0356	it plays a direct role in the translocation of protons across the membrane
AMES_7666	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMES_7669	COG2890	protein-(glutamine-N5) methyltransferase activity
AMES_7670	COG0463	Glycosyl transferase, family 2
AMES_7674	COG0254	rRNA binding
AMES_7676	COG0083	homoserine kinase activity
AMES_7677	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMES_7678	COG0460	homoserine dehydrogenase
AMES_7679	COG0019	diaminopimelate decarboxylase activity
AMES_7680	COG0018	arginyl-trna synthetase
AMES_7686	COG0596	Alpha beta hydrolase
AMES_7700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMES_7702	COG3629	intracellular signal transduction
AMES_7702	COG3903	Transcriptional regulator
AMES_7703	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMES_7703	COG2124	cytochrome p450
AMES_7707	COG3345	alpha-galactosidase
AMES_7712	COG3693	PFAM glycoside hydrolase, family 10
AMES_7725	COG5433	transposase activity
AMES_7735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMES_7736	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMES_7740	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_7742	COG0145	ligase activity
AMES_7746	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AMES_7749	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMES_7752	COG0154	amidase activity
AMES_7758	COG0473	3-isopropylmalate dehydrogenase activity
AMES_7762	COG0667	Aldo Keto reductase
AMES_7766	COG0028	Belongs to the TPP enzyme family
AMES_7771	COG4585	Histidine kinase
AMES_7772	COG2197	response regulator
AMES_7773	COG3537	Alpha-1,2-mannosidase
AMES_7774	COG2409	Drug exporters of the RND superfamily
AMES_7775	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_7775	COG1024	Enoyl-CoA hydratase
AMES_7776	COG0183	Belongs to the thiolase family
AMES_7777	COG1309	transcriptional regulator
AMES_7784	COG1960	acyl-CoA dehydrogenase activity
AMES_7785	COG1960	acyl-CoA dehydrogenase activity
AMES_7796	COG4221	oxidoreductase activity
AMES_7802	COG1960	acyl-CoA dehydrogenase activity
AMES_7804	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMES_7810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMES_7812	COG0346	lactoylglutathione lyase activity
AMES_7817	COG2226	methyltransferase
AMES_7818	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMES_7818	COG2508	Transcriptional regulator
AMES_7821	COG0686	Belongs to the AlaDH PNT family
AMES_7823	COG2205	protein histidine kinase activity
AMES_7825	COG0745	RESPONSE REGULATOR receiver
AMES_7828	COG1132	(ABC) transporter
AMES_7831	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMES_7831	COG0567	Dehydrogenase, E1 component
AMES_7833	COG1216	Glycosyl transferase, family 2
AMES_7834	COG2223	nitrite transmembrane transporter activity
AMES_7836	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_7839	COG1174	glycine betaine transport
AMES_7840	COG1174	glycine betaine transport
AMES_7841	COG0517	IMP dehydrogenase activity
AMES_7841	COG1125	glycine betaine transport
AMES_7844	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMES_7846	COG1846	Transcriptional regulator
AMES_7849	COG0406	alpha-ribazole phosphatase activity
AMES_7852	COG1597	lipid kinase activity
AMES_7856	COG1595	DNA-templated transcription, initiation
AMES_7857	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMES_7859	COG2135	peptidase activity
AMES_7865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMES_7866	COG1011	Hydrolase
AMES_7869	COG0653	protein targeting
AMES_7870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AMES_7872	COG5401	PFAM Sporulation and spore germination
AMES_7873	COG5000	phosphorelay sensor kinase activity
AMES_7873	COG5002	protein histidine kinase activity
AMES_7874	COG0745	RESPONSE REGULATOR receiver
AMES_7877	COG1414	Transcriptional regulator
AMES_7890	COG0531	amino acid
AMES_7892	COG3903	Transcriptional regulator
AMES_7892	COG3629	intracellular signal transduction
AMES_7893	COG1482	cell wall glycoprotein biosynthetic process
AMES_7895	COG2835	tetraacyldisaccharide 4'-kinase activity
AMES_7896	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMES_7904	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMES_7907	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMES_7908	COG0601	transmembrane transport
AMES_7910	COG0747	negative chemotaxis
AMES_7913	COG0180	Tryptophanyl-tRNA synthetase
AMES_7915	COG2205	protein histidine kinase activity
AMES_7916	COG0745	RESPONSE REGULATOR receiver
AMES_7918	COG1131	(ABC) transporter
AMES_7920	COG3842	ATPase activity
AMES_7921	COG4149	molybdate abc transporter
AMES_7923	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMES_7927	COG0012	GTP binding
AMES_7930	COG0419	ATPase involved in DNA repair
AMES_7931	COG0420	3'-5' exonuclease activity
AMES_7933	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMES_7935	COG1570	exodeoxyribonuclease VII activity
AMES_7937	COG1722	exodeoxyribonuclease VII activity
AMES_7940	COG0492	ferredoxin-NADP+ reductase activity
AMES_7941	COG0114	fumarate hydratase activity
AMES_7943	COG1793	dna ligase
AMES_7946	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMES_7952	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMES_7957	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AMES_7963	COG1331	Highly conserved protein containing a thioredoxin domain
AMES_7965	COG2890	protein-(glutamine-N5) methyltransferase activity
AMES_7966	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMES_7968	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMES_7970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMES_7971	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMES_7973	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AMES_7979	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMES_7986	COG0183	Belongs to the thiolase family
AMES_7997	COG2723	6-phospho-beta-galactosidase activity
AMES_7998	COG3903	Transcriptional regulator
AMES_7998	COG3629	intracellular signal transduction
AMES_8000	COG1175	transmembrane transport
AMES_8003	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_8004	COG0667	Aldo Keto reductase
AMES_8005	COG0477	Major facilitator Superfamily
AMES_8012	COG2207	Transcriptional regulator
AMES_8015	COG5297	Belongs to the glycosyl hydrolase family 6
AMES_8018	COG2205	protein histidine kinase activity
AMES_8019	COG0148	phosphopyruvate hydratase activity
AMES_8021	COG1132	(ABC) transporter
AMES_8040	COG1595	DNA-templated transcription, initiation
AMES_8041	COG2815	serine threonine protein kinase
AMES_8041	COG0515	serine threonine protein kinase
AMES_8048	COG1191	sigma factor activity
AMES_8061	COG1515	deoxyribonuclease V activity
AMES_8064	COG4608	Belongs to the ABC transporter superfamily
AMES_8065	COG0444	Belongs to the ABC transporter superfamily
AMES_8073	COG0148	phosphopyruvate hydratase activity
AMES_8077	COG0672	)-iron permease
AMES_8078	COG2822	iron ion transport
AMES_8079	COG2837	iron assimilation
AMES_8085	COG1131	(ABC) transporter
AMES_8094	COG0586	Pfam SNARE associated Golgi protein
AMES_8097	COG4585	Histidine kinase
AMES_8098	COG2197	response regulator
AMES_8099	COG2133	pyrroloquinoline quinone binding
AMES_8103	COG1051	belongs to the nudix hydrolase family
AMES_8104	COG1309	transcriptional regulator
AMES_8107	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMES_8113	COG0193	aminoacyl-tRNA hydrolase activity
AMES_8116	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_8117	COG0488	(ABC) transporter
AMES_8119	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMES_8120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMES_8121	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMES_8122	COG3583	domain protein
AMES_8123	COG0084	hydrolase, TatD family'
AMES_8124	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMES_8135	COG2815	serine threonine protein kinase
AMES_8135	COG0515	serine threonine protein kinase
AMES_8136	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMES_8140	COG2258	MOSC domain
AMES_8143	COG1595	DNA-templated transcription, initiation
AMES_8151	COG5001	Diguanylate cyclase
AMES_8153	COG2124	cytochrome p450
AMES_8154	COG1192	Involved in chromosome partitioning
AMES_8159	COG0745	RESPONSE REGULATOR receiver
AMES_8160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMES_8161	COG2205	protein histidine kinase activity
AMES_8162	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMES_8164	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMES_8165	COG1733	regulation of RNA biosynthetic process
AMES_8166	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AMES_8167	COG2226	methyltransferase
AMES_8167	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMES_8167	COG3433	isochorismatase activity
AMES_8170	COG1280	lysine exporter protein (LysE YggA)
AMES_8172	COG0515	serine threonine protein kinase
AMES_8181	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMES_8183	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMES_8184	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMES_8189	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMES_8189	COG0315	cyclic pyranopterin monophosphate synthase activity
AMES_8193	COG5002	protein histidine kinase activity
AMES_8194	COG0745	RESPONSE REGULATOR receiver
AMES_8198	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMES_8203	COG1349	DNA-binding transcription factor activity
AMES_8206	COG2860	membrane
AMES_8207	COG2197	response regulator
AMES_8208	COG2264	protein methyltransferase activity
AMES_8209	COG0477	Major facilitator Superfamily
AMES_8210	COG0667	Aldo Keto reductase
AMES_8212	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMES_8215	COG0515	serine threonine protein kinase
AMES_8215	COG2815	serine threonine protein kinase
AMES_8216	COG0483	inositol monophosphate 1-phosphatase activity
AMES_8217	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMES_8221	COG0297	glycogen (starch) synthase activity
AMES_8225	COG1793	dna ligase
AMES_8225	COG3285	dna ligase
AMES_8227	COG0583	DNA-binding transcription factor activity
AMES_8230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMES_8230	COG2755	lipolytic protein G-D-S-L family
AMES_8241	COG0444	Belongs to the ABC transporter superfamily
AMES_8242	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMES_8243	COG0601	transmembrane transport
AMES_8245	COG0747	negative chemotaxis
AMES_8251	COG3469	chitinase activity
AMES_8254	COG4336	lyase activity
AMES_8255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMES_8256	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMES_8257	COG1984	allophanate hydrolase subunit 2
AMES_8265	COG1321	iron dependent repressor
AMES_8269	COG1024	Enoyl-CoA hydratase
AMES_8270	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_8274	COG1169	isochorismate synthase
AMES_8278	COG2182	Extracellular solute-binding protein
AMES_8279	COG1175	transmembrane transport
AMES_8280	COG0395	ABC-type sugar transport system, permease component
AMES_8285	COG1595	DNA-templated transcription, initiation
AMES_8287	COG0277	FAD linked oxidase domain protein
AMES_8293	COG4152	abc transporter atp-binding protein
AMES_8295	COG0415	Belongs to the DNA photolyase family
AMES_8300	COG1960	acyl-CoA dehydrogenase activity
AMES_8305	COG2017	converts alpha-aldose to the beta-anomer
AMES_8307	COG1309	transcriptional regulator
AMES_8312	COG0259	pyridoxamine-phosphate oxidase activity
AMES_8316	COG0829	nickel cation binding
AMES_8317	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AMES_8319	COG0804	urea catabolic process
AMES_8320	COG0832	Belongs to the urease beta subunit family
AMES_8321	COG0831	urea catabolic process
AMES_8328	COG2197	response regulator
AMES_8329	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMES_8331	COG5650	phosphatidylinositol metabolic process
AMES_8333	COG1228	amidohydrolase
AMES_8334	COG0577	efflux transmembrane transporter activity
AMES_8334	COG1136	(ABC) transporter
AMES_8335	COG1136	(ABC) transporter
AMES_8335	COG0577	efflux transmembrane transporter activity
AMES_8338	COG0745	RESPONSE REGULATOR receiver
AMES_8339	COG2205	protein histidine kinase activity
AMES_8344	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMES_8349	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AMES_8350	COG2814	Major facilitator Superfamily
AMES_8353	COG2252	PERMEase
AMES_8358	COG2814	Major facilitator Superfamily
AMES_8359	COG1278	Cold shock
AMES_8364	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMES_8365	COG0318	PFAM AMP-dependent synthetase and ligase
AMES_8367	COG1595	DNA-templated transcription, initiation
AMES_8369	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMES_8377	COG0384	phenazine biosynthesis protein PhzF
AMES_8378	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMES_8379	COG3304	Inner membrane component domain
AMES_8386	COG1846	Transcriptional regulator
AMES_8387	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMES_8389	COG1388	LysM domain
AMES_8398	COG2018	Roadblock/LC7 domain
AMES_8401	COG2018	Roadblock/LC7 domain
AMES_8402	COG0642	Histidine kinase
AMES_8403	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMES_8404	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMES_8405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMES_8406	COG1116	anion transmembrane transporter activity
AMES_8412	COG3142	Participates in the control of copper homeostasis
AMES_8416	COG1061	Type III restriction enzyme res subunit
AMES_8420	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_8423	COG0459	protein refolding
AMES_8425	COG1278	Cold shock
AMES_8431	COG2261	transglycosylase associated protein
AMES_8432	COG0688	phosphatidylethanolamine metabolic process
AMES_8434	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMES_8437	COG0242	peptide deformylase activity
AMES_8439	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMES_8440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMES_8441	COG0351	phosphomethylpyrimidine kinase
AMES_8445	COG2022	thiamine diphosphate biosynthetic process
AMES_8448	COG0352	thiamine-phosphate diphosphorylase activity
AMES_8450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMES_8451	COG0477	Major facilitator Superfamily
AMES_8453	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMES_8454	COG2971	BadF BadG BcrA BcrD
AMES_8456	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMES_8462	COG3903	Transcriptional regulator
AMES_8462	COG3629	intracellular signal transduction
AMES_8463	COG5285	phytanoyl-CoA dioxygenase
AMES_8464	COG1917	Cupin 2, conserved barrel domain protein
AMES_8467	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMES_8469	COG4399	Belongs to the UPF0754 family
AMES_8470	COG1733	regulation of RNA biosynthetic process
AMES_8472	COG5416	Lipopolysaccharide assembly protein A domain
AMES_8485	COG1733	regulation of RNA biosynthetic process
AMES_8493	COG0346	lactoylglutathione lyase activity
AMES_8496	COG1832	CoA-binding protein
AMES_8504	COG0745	RESPONSE REGULATOR receiver
AMES_8505	COG2205	protein histidine kinase activity
AMES_8506	COG1492	cobalamin metabolic process
AMES_8507	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMES_8509	COG1309	transcriptional regulator
AMES_8511	COG1620	l-lactate permease
AMES_8512	COG4941	Belongs to the sigma-70 factor family
AMES_8514	COG3795	YCII-related domain
AMES_8515	COG3795	YCII-related domain
AMES_8518	COG2205	protein histidine kinase activity
AMES_8525	COG1595	DNA-templated transcription, initiation
AMES_8535	COG0789	Transcriptional regulator
AMES_8538	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AMES_8545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMES_8547	COG1329	Transcriptional regulator
AMES_8548	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMES_8549	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMES_8553	COG0215	cysteine-tRNA ligase activity
AMES_8560	COG0235	Class ii aldolase
AMES_8564	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMES_8565	COG4399	Belongs to the UPF0754 family
AMES_8566	COG1121	(ABC) transporter
AMES_8567	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMES_8568	COG1609	Transcriptional regulator
AMES_8574	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMES_8577	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMES_8593	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AMES_8595	COG1396	sequence-specific DNA binding
AMES_8601	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMES_8603	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMES_8604	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMES_8605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMES_8610	COG0789	Transcriptional regulator
AMES_8613	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMES_8615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMES_8621	COG0037	tRNA processing
AMES_8624	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMES_8626	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMES_8627	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMES_8643	COG2188	Transcriptional regulator
AMES_8647	COG1674	ftsk spoiiie
AMES_8654	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMES_8655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMES_8661	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMES_8661	COG1754	DNA topoisomerase type I activity
AMES_8665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMES_8666	COG1111	helicase
AMES_8666	COG1205	dead DEAH box helicase
AMES_8675	COG1472	Belongs to the glycosyl hydrolase 3 family
AMES_8676	COG3876	Protein conserved in bacteria
AMES_8677	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMES_8678	COG1737	Transcriptional regulator
AMES_8679	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AMES_8681	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMES_8682	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AMES_8684	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMES_8688	COG3104	oligopeptide transport
AMES_8689	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AMES_8692	COG0596	Alpha beta hydrolase
AMES_8707	COG2272	Belongs to the type-B carboxylesterase lipase family
AMES_8708	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMES_8716	COG2894	cell division
AMES_8718	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMES_8720	COG1408	metallophosphoesterase
AMES_8721	COG2226	methyltransferase
AMES_8728	COG0463	Glycosyl transferase, family 2
AMES_8729	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AMES_8731	COG2192	nodulation
AMES_8734	COG0076	glutamate decarboxylase activity
AMES_8735	COG0783	Belongs to the Dps family
AMES_8736	COG1764	response to oxidative stress
AMES_8741	COG2814	Major facilitator Superfamily
AMES_8744	COG1690	Belongs to the RtcB family
AMES_8751	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMES_8756	COG0583	DNA-binding transcription factor activity
AMES_8759	COG0697	spore germination
AMES_8761	COG3795	YCII-related domain
AMES_8762	COG4941	Belongs to the sigma-70 factor family
AMES_8763	COG4608	Belongs to the ABC transporter superfamily
AMES_8767	COG0747	negative chemotaxis
AMES_8769	COG1216	Glycosyl transferase, family 2
AMES_8773	COG1215	transferase activity, transferring glycosyl groups
AMES_8775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMES_8776	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMES_8777	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMES_8778	COG1733	regulation of RNA biosynthetic process
AMES_8780	COG3467	pyridoxamine 5'-phosphate
AMES_8781	COG2801	Transposase and inactivated derivatives
AMES_8790	COG1116	anion transmembrane transporter activity
AMES_8791	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMES_8793	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMES_8794	COG2205	protein histidine kinase activity
AMES_8795	COG0745	RESPONSE REGULATOR receiver
AMES_8798	COG2197	response regulator
AMES_8802	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMES_8803	COG5479	isomerase activity
AMES_8803	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMES_8811	COG1674	ftsk spoiiie
AMES_8819	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
AMES_8820	COG2175	clavaminate synthase activity
AMES_8830	COG4702	Belongs to the UPF0303 family
AMES_8832	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMES_8833	COG0789	Transcriptional regulator
AMES_8834	COG0395	ABC-type sugar transport system, permease component
AMES_8835	COG1175	transmembrane transport
AMES_8838	COG1802	Transcriptional regulator
AMES_8844	COG3973	AAA domain
AMES_8850	COG0673	inositol 2-dehydrogenase activity
AMES_8853	COG3345	alpha-galactosidase
AMES_8856	COG2188	Transcriptional regulator
AMES_8857	COG1397	ADP-ribosylglycohydrolase
AMES_8858	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMES_8861	COG0596	Alpha beta hydrolase
AMES_8862	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AMES_8863	COG3706	GGDEF domain
AMES_8863	COG0745	RESPONSE REGULATOR receiver
AMES_8865	COG1316	TRANSCRIPTIONal
AMES_8867	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMES_8868	COG0581	inorganic phosphate transmembrane transporter activity
AMES_8870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMES_8872	COG0745	RESPONSE REGULATOR receiver
AMES_8878	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AMES_8879	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMES_8880	COG1984	allophanate hydrolase subunit 2
AMES_8890	COG3845	ABC transporter
AMES_8897	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMES_8910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMES_8912	COG1132	(ABC) transporter
AMES_8913	COG0047	phosphoribosylformylglycinamidine synthase activity
AMES_8914	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMES_8923	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMES_8925	COG1126	abc transporter atp-binding protein
AMES_8926	COG0765	amino acid transport
AMES_8928	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMES_8930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMES_8931	COG4948	Mandelate Racemase Muconate Lactonizing
AMES_8935	COG2186	Transcriptional regulator
AMES_8939	COG0546	phosphoglycolate phosphatase activity
AMES_8942	COG0436	Aminotransferase
AMES_8943	COG3953	SLT domain
AMES_8943	COG5280	Phage tail tape measure protein TP901
AMES_8950	COG0584	glycerophosphoryl diester phosphodiesterase
AMES_8955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMES_8957	COG2814	Major facilitator Superfamily
AMES_8958	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMES_8959	COG0025	NhaP-type Na H and K H
AMES_8961	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMES_8968	COG3706	GGDEF domain
AMES_8968	COG0745	RESPONSE REGULATOR receiver
AMES_8975	COG0667	Aldo Keto reductase
AMES_8976	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_8986	COG0586	Pfam SNARE associated Golgi protein
AMES_8988	COG0277	FAD linked oxidase domain protein
AMES_8989	COG3467	pyridoxamine 5'-phosphate
AMES_8993	COG0586	Pfam SNARE associated Golgi protein
AMES_8996	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_8997	COG0572	uridine kinase
AMES_8998	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMES_9005	COG0243	molybdopterin cofactor binding
AMES_9014	COG1136	(ABC) transporter
AMES_9015	COG4221	oxidoreductase activity
AMES_9018	COG0542	response to heat
AMES_9023	COG0412	Dienelactone hydrolase
AMES_9026	COG0789	Transcriptional regulator
AMES_9027	COG0484	heat shock protein binding
AMES_9028	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMES_9029	COG0443	Heat shock 70 kDa protein
AMES_9036	COG0247	lactate metabolic process
AMES_9036	COG2181	nitrate reductase activity
AMES_9039	COG2340	Cysteine-rich secretory protein family
AMES_9046	COG4941	Belongs to the sigma-70 factor family
AMES_9047	COG3795	YCII-related domain
AMES_9049	COG2124	cytochrome p450
AMES_9057	COG3663	DNA glycosylase
AMES_9058	COG2197	response regulator
AMES_9059	COG1960	acyl-CoA dehydrogenase activity
AMES_9061	COG0477	Major facilitator Superfamily
AMES_9065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMES_9070	COG1126	abc transporter atp-binding protein
AMES_9076	COG1305	Transglutaminase-like
AMES_9077	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMES_9080	COG0022	dehydrogenase e1 component
AMES_9081	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMES_9086	COG3030	protein affecting phage T7 exclusion by the F plasmid
AMES_9094	COG2030	dehydratase
AMES_9095	COG1309	transcriptional regulator
AMES_9096	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_9097	COG0183	Belongs to the thiolase family
AMES_9112	COG1131	(ABC) transporter
AMES_9115	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AMES_9118	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMES_9121	COG4585	Histidine kinase
AMES_9122	COG2197	response regulator
AMES_9123	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_9127	COG1131	(ABC) transporter
AMES_9130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMES_9132	COG1136	(ABC) transporter
AMES_9135	COG2197	response regulator
AMES_9137	COG4221	oxidoreductase activity
AMES_9138	COG0402	S-adenosylhomocysteine deaminase activity
AMES_9141	COG2814	Major facilitator Superfamily
AMES_9142	COG1846	Transcriptional regulator
AMES_9144	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMES_9145	COG1595	DNA-templated transcription, initiation
AMES_9147	COG1695	Transcriptional regulator
AMES_9149	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMES_9150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMES_9151	COG0673	inositol 2-dehydrogenase activity
AMES_9152	COG1940	carbohydrate kinase activity
AMES_9158	COG0360	Binds together with S18 to 16S ribosomal RNA
AMES_9160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMES_9161	COG0359	binds to the 23S rRNA
AMES_9169	COG3384	dioxygenase
AMES_9173	COG2197	response regulator
AMES_9176	COG0477	Major facilitator Superfamily
AMES_9177	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMES_9179	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMES_9189	COG1028	Short-chain dehydrogenase reductase Sdr
AMES_9191	COG0495	leucyl-tRNA aminoacylation
AMES_9193	COG1678	Uncharacterized ACR, COG1678
AMES_9207	COG0617	tRNA 3'-terminal CCA addition
AMES_9215	COG3118	belongs to the thioredoxin family
AMES_9215	COG0492	ferredoxin-NADP+ reductase activity
AMES_9216	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMES_9216	COG3409	Peptidoglycan-binding domain 1 protein
AMES_9219	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMES_9221	COG1192	Involved in chromosome partitioning
AMES_9222	COG0357	Ribosomal RNA small subunit methyltransferase G
AMES_9225	COG0706	membrane insertase activity
AMES_9226	COG0759	Could be involved in insertion of integral membrane proteins into the membrane