locus-tag	class	description
AMED_0002	COG0592	DNA-directed DNA polymerase activity
AMED_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMED_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMED_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AMED_0006	COG0187	DNA topoisomerase II activity
AMED_0029	COG0596	Alpha beta hydrolase
AMED_0036	COG0457	Tetratricopeptide repeat
AMED_0036	COG0705	Rhomboid family
AMED_0039	COG3764	Sortase (surface protein transpeptidase)
AMED_0051	COG2815	serine threonine protein kinase
AMED_0051	COG0515	serine threonine protein kinase
AMED_0052	COG0515	serine threonine protein kinase
AMED_0053	COG0768	penicillin binding
AMED_0056	COG1716	ATPase activity
AMED_0057	COG1716	ATPase activity
AMED_0062	COG0626	cystathionine gamma-synthase activity
AMED_0066	COG2186	Transcriptional regulator
AMED_0067	COG0747	negative chemotaxis
AMED_0070	COG0444	Belongs to the ABC transporter superfamily
AMED_0071	COG4608	Belongs to the ABC transporter superfamily
AMED_0072	COG1012	belongs to the aldehyde dehydrogenase family
AMED_0073	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_0074	COG0154	amidase activity
AMED_0079	COG2301	Belongs to the HpcH HpaI aldolase family
AMED_0081	COG0702	epimerase
AMED_0082	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMED_0085	COG1309	transcriptional regulator
AMED_0087	COG2211	Major facilitator Superfamily
AMED_0093	COG2372	response to copper ion
AMED_0093	COG1276	copper resistance
AMED_0096	COG1174	glycine betaine transport
AMED_0098	COG1174	glycine betaine transport
AMED_0103	COG2226	methyltransferase
AMED_0105	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMED_0106	COG0405	Gamma-glutamyltransferase
AMED_0108	COG5433	transposase activity
AMED_0111	COG0477	Major facilitator Superfamily
AMED_0113	COG4585	Histidine kinase
AMED_0114	COG2197	response regulator
AMED_0120	COG0438	transferase activity, transferring glycosyl groups
AMED_0130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMED_0131	COG3275	phosphorelay sensor kinase activity
AMED_0136	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMED_0137	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMED_0137	COG0425	Belongs to the sulfur carrier protein TusA family
AMED_0141	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMED_0145	COG1191	sigma factor activity
AMED_0148	COG2235	arginine
AMED_0163	COG1271	oxidase subunit
AMED_0164	COG1294	oxidase, subunit
AMED_0165	COG4988	ABC transporter
AMED_0176	COG4715	Zinc finger, swim domain protein
AMED_0179	COG1072	(Pantothenic acid kinase))
AMED_0180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMED_0182	COG0406	alpha-ribazole phosphatase activity
AMED_0189	COG0754	glutathionylspermidine amidase activity
AMED_0191	COG0596	Alpha beta hydrolase
AMED_0192	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMED_0193	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMED_0195	COG0579	oxidoreductase
AMED_0200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AMED_0203	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMED_0209	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMED_0211	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_0212	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_0221	COG0561	phosphatase activity
AMED_0222	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_0226	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMED_0229	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_0230	COG0277	FAD linked oxidase domain protein
AMED_0232	COG1216	Glycosyl transferase, family 2
AMED_0238	COG1216	Glycosyl transferase, family 2
AMED_0243	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_0243	COG0604	alcohol dehydrogenase
AMED_0243	COG3321	synthase
AMED_0244	COG2234	aminopeptidase activity
AMED_0255	COG4565	transcriptional regulatory protein
AMED_0256	COG3290	protein histidine kinase activity
AMED_0257	COG1116	anion transmembrane transporter activity
AMED_0262	COG1672	PFAM Archaeal ATPase
AMED_0262	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMED_0265	COG1522	sequence-specific DNA binding
AMED_0266	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMED_0268	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMED_0269	COG2186	Transcriptional regulator
AMED_0272	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMED_0274	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMED_0278	COG3469	chitinase activity
AMED_0279	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AMED_0284	COG3583	domain protein
AMED_0284	COG3584	3D domain protein
AMED_0298	COG3559	Exporter of polyketide antibiotics
AMED_0299	COG1131	(ABC) transporter
AMED_0310	COG0287	Prephenate dehydrogenase
AMED_0311	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMED_0311	COG1902	pentaerythritol trinitrate reductase activity
AMED_0315	COG1846	Transcriptional regulator
AMED_0321	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMED_0323	COG2318	DinB family
AMED_0325	COG0194	GDP metabolic process
AMED_0336	COG0515	serine threonine protein kinase
AMED_0339	COG0028	Belongs to the TPP enzyme family
AMED_0343	COG3199	ATP-NAD kinase
AMED_0344	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMED_0347	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMED_0348	COG0515	serine threonine protein kinase
AMED_0379	COG2226	methyltransferase
AMED_0387	COG2233	PERMEase
AMED_0388	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMED_0390	COG1414	Transcriptional regulator
AMED_0394	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AMED_0412	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AMED_0416	COG2364	Membrane
AMED_0417	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_0420	COG2733	membrane
AMED_0424	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMED_0431	COG2986	histidine ammonia-lyase
AMED_0436	COG1174	glycine betaine transport
AMED_0439	COG1846	Transcriptional regulator
AMED_0441	COG2130	NADP-dependent
AMED_0444	COG1064	alcohol dehydrogenase
AMED_0450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMED_0453	COG0438	transferase activity, transferring glycosyl groups
AMED_0456	COG0588	phosphoglycerate mutase activity
AMED_0458	COG0667	Aldo Keto reductase
AMED_0459	COG5002	protein histidine kinase activity
AMED_0466	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMED_0470	COG4585	Histidine kinase
AMED_0473	COG0560	Phosphoserine phosphatase
AMED_0475	COG1595	DNA-templated transcription, initiation
AMED_0476	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_0479	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMED_0480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMED_0481	COG0181	hydroxymethylbilane synthase activity
AMED_0482	COG1648	precorrin-2 dehydrogenase activity
AMED_0482	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMED_0489	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMED_0490	COG1136	(ABC) transporter
AMED_0490	COG0577	efflux transmembrane transporter activity
AMED_0491	COG0577	efflux transmembrane transporter activity
AMED_0491	COG1136	(ABC) transporter
AMED_0494	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMED_0495	COG0406	alpha-ribazole phosphatase activity
AMED_0496	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMED_0497	COG0785	Cytochrome C biogenesis protein
AMED_0499	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMED_0503	COG1522	sequence-specific DNA binding
AMED_0510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AMED_0515	COG0438	transferase activity, transferring glycosyl groups
AMED_0518	COG2226	methyltransferase
AMED_0519	COG0644	oxidoreductase
AMED_0521	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMED_0522	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMED_0523	COG0649	NAD binding
AMED_0526	COG1034	ATP synthesis coupled electron transport
AMED_0527	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMED_0528	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMED_0529	COG0839	Belongs to the complex I subunit 6 family
AMED_0530	COG0713	ATP synthesis coupled electron transport
AMED_0531	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMED_0533	COG1007	ATP synthesis coupled electron transport
AMED_0540	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMED_0541	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMED_0541	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMED_0543	COG1522	sequence-specific DNA binding
AMED_0544	COG1834	amidinotransferase
AMED_0547	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMED_0548	COG0438	transferase activity, transferring glycosyl groups
AMED_0551	COG0367	asparagine synthase
AMED_0560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMED_0561	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMED_0563	COG1215	transferase activity, transferring glycosyl groups
AMED_0565	COG4310	Domain of unknown function (DUF2172)
AMED_0568	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMED_0571	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_0579	COG1666	GTP binding
AMED_0582	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMED_0586	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMED_0587	COG2030	dehydratase
AMED_0591	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_0595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMED_0596	COG0081	regulation of translation
AMED_0599	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMED_0603	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMED_0608	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMED_0613	COG0673	inositol 2-dehydrogenase activity
AMED_0625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMED_0626	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMED_0629	COG0546	phosphoglycolate phosphatase activity
AMED_0631	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMED_0633	COG0477	Major facilitator Superfamily
AMED_0636	COG2124	cytochrome p450
AMED_0637	COG2124	cytochrome p450
AMED_0641	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMED_0644	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_0649	COG2124	cytochrome p450
AMED_0651	COG3959	Transketolase, thiamine diphosphate binding domain
AMED_0652	COG3958	Transketolase
AMED_0654	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMED_0657	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMED_0659	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMED_0660	COG1522	sequence-specific DNA binding
AMED_0661	COG0477	Major facilitator Superfamily
AMED_0663	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMED_0663	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_0672	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMED_0673	COG0049	tRNA binding
AMED_0674	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMED_0676	COG0051	transcription antitermination factor activity, RNA binding
AMED_0677	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMED_0678	COG0088	Forms part of the polypeptide exit tunnel
AMED_0679	COG0089	rRNA binding
AMED_0680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMED_0681	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMED_0682	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMED_0683	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMED_0684	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMED_0685	COG0255	Belongs to the universal ribosomal protein uL29 family
AMED_0686	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMED_0687	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMED_0688	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMED_0689	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMED_0691	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMED_0692	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMED_0693	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMED_0694	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMED_0695	COG1841	ribosomal large subunit assembly
AMED_0696	COG0200	Binds to the 23S rRNA
AMED_0698	COG1280	lysine exporter protein (LysE YggA)
AMED_0700	COG0563	adenylate kinase activity
AMED_0703	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMED_0704	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMED_0706	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMED_0707	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMED_0708	COG0202	RNA polymerase activity
AMED_0709	COG0203	ribosomal protein L17
AMED_0710	COG0101	tRNA pseudouridine synthase activity
AMED_0717	COG1404	Belongs to the peptidase S8 family
AMED_0719	COG1674	ftsk spoiiie
AMED_0720	COG0443	Heat shock 70 kDa protein
AMED_0726	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMED_0727	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMED_0728	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMED_0738	COG1349	DNA-binding transcription factor activity
AMED_0739	COG1070	Carbohydrate kinase
AMED_0740	COG3842	ATPase activity
AMED_0741	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMED_0743	COG0802	atpase or kinase
AMED_0745	COG0825	malonyl-CoA metabolic process
AMED_0745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMED_0746	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_0748	COG0456	acetyltransferase
AMED_0749	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMED_0750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AMED_0754	COG1215	transferase activity, transferring glycosyl groups
AMED_0756	COG2226	methyltransferase
AMED_0759	COG0798	PFAM Bile acid sodium symporter
AMED_0760	COG0640	Transcriptional regulator
AMED_0762	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMED_0763	COG0459	protein refolding
AMED_0773	COG0516	GMP reductase activity
AMED_0777	COG0277	FAD linked oxidase domain protein
AMED_0778	COG1012	belongs to the aldehyde dehydrogenase family
AMED_0782	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMED_0782	COG0519	Catalyzes the synthesis of GMP from XMP
AMED_0785	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_0789	COG0697	spore germination
AMED_0790	COG0583	DNA-binding transcription factor activity
AMED_0792	COG0515	serine threonine protein kinase
AMED_0792	COG2815	serine threonine protein kinase
AMED_0802	COG0045	succinate-CoA ligase (ADP-forming) activity
AMED_0807	COG0138	bifunctional purine biosynthesis protein purh
AMED_0815	COG0587	DNA-directed DNA polymerase activity
AMED_0819	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMED_0821	COG2814	Major facilitator Superfamily
AMED_0822	COG0640	Transcriptional regulator
AMED_0823	COG2814	Major facilitator Superfamily
AMED_0825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMED_0830	COG2226	methyltransferase
AMED_0837	COG1234	tRNA 3'-trailer cleavage
AMED_0840	COG0180	Tryptophanyl-tRNA synthetase
AMED_0842	COG1295	ribonuclease BN
AMED_0844	COG1733	regulation of RNA biosynthetic process
AMED_0849	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMED_0852	COG2009	succinate dehydrogenase
AMED_0853	COG3345	alpha-galactosidase
AMED_0854	COG1082	Xylose isomerase domain protein TIM barrel
AMED_0862	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMED_0863	COG2271	Major facilitator Superfamily
AMED_0868	COG1733	regulation of RNA biosynthetic process
AMED_0870	COG1063	alcohol dehydrogenase
AMED_0873	COG0395	ABC-type sugar transport system, permease component
AMED_0880	COG1012	belongs to the aldehyde dehydrogenase family
AMED_0881	COG1012	belongs to the aldehyde dehydrogenase family
AMED_0882	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMED_0890	COG0789	Transcriptional regulator
AMED_0891	COG0667	Aldo Keto reductase
AMED_0895	COG0475	glutathione-regulated potassium exporter activity
AMED_0896	COG0745	RESPONSE REGULATOR receiver
AMED_0897	COG2205	protein histidine kinase activity
AMED_0901	COG0402	S-adenosylhomocysteine deaminase activity
AMED_0906	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMED_0912	COG0515	serine threonine protein kinase
AMED_0917	COG1473	amidohydrolase
AMED_0917	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMED_0925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMED_0926	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMED_0927	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMED_0934	COG4770	biotin carboxylase activity
AMED_0937	COG1301	dicarboxylic acid transport
AMED_0938	COG0424	maF-like protein
AMED_0939	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_0943	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_0944	COG1846	Transcriptional regulator
AMED_0946	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMED_0949	COG4585	Histidine kinase
AMED_0953	COG1309	transcriptional regulator
AMED_0955	COG1733	regulation of RNA biosynthetic process
AMED_0957	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_0960	COG0583	DNA-binding transcription factor activity
AMED_0963	COG2226	methyltransferase
AMED_0966	COG1902	pentaerythritol trinitrate reductase activity
AMED_0966	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMED_0970	COG4585	Histidine kinase
AMED_0971	COG2197	response regulator
AMED_0972	COG3103	Sh3 type 3 domain protein
AMED_0972	COG1388	LysM domain
AMED_0972	COG0791	NLP P60 protein
AMED_0975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMED_0978	COG3537	Alpha-1,2-mannosidase
AMED_0979	COG0483	inositol monophosphate 1-phosphatase activity
AMED_0981	COG2205	protein histidine kinase activity
AMED_0982	COG2197	response regulator
AMED_0983	COG2197	response regulator
AMED_0996	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_0999	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMED_1005	COG1316	TRANSCRIPTIONal
AMED_1006	COG1316	TRANSCRIPTIONal
AMED_1012	COG0438	transferase activity, transferring glycosyl groups
AMED_1019	COG1725	Transcriptional regulator
AMED_1022	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AMED_1022	COG0778	Nitroreductase
AMED_1041	COG1611	Belongs to the LOG family
AMED_1045	COG1216	Glycosyl transferase, family 2
AMED_1050	COG0463	Glycosyl transferase, family 2
AMED_1051	COG1132	(ABC) transporter
AMED_1052	COG4988	ABC transporter
AMED_1053	COG1294	oxidase, subunit
AMED_1054	COG1271	oxidase subunit
AMED_1059	COG2818	Glycosylase
AMED_1060	COG1024	Enoyl-CoA hydratase
AMED_1062	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMED_1063	COG0583	DNA-binding transcription factor activity
AMED_1064	COG2814	Major facilitator Superfamily
AMED_1066	COG4122	O-methyltransferase activity
AMED_1067	COG1595	DNA-templated transcription, initiation
AMED_1069	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMED_1070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMED_1073	COG2239	Acts as a magnesium transporter
AMED_1075	COG0330	HflC and HflK could
AMED_1086	COG1309	transcriptional regulator
AMED_1088	COG2197	response regulator
AMED_1089	COG4585	Histidine kinase
AMED_1096	COG0598	Magnesium transport protein CorA
AMED_1102	COG0613	PHP domain protein
AMED_1103	COG2095	MarC family integral membrane protein
AMED_1108	COG0513	Belongs to the DEAD box helicase family
AMED_1115	COG2267	carboxylic ester hydrolase activity
AMED_1116	COG1309	transcriptional regulator
AMED_1117	COG2267	carboxylic ester hydrolase activity
AMED_1121	COG0243	molybdopterin cofactor binding
AMED_1122	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMED_1124	COG2146	nitrite reductase [NAD(P)H] activity
AMED_1124	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMED_1125	COG2146	nitrite reductase [NAD(P)H] activity
AMED_1125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMED_1130	COG2378	regulation of single-species biofilm formation
AMED_1142	COG0714	Associated with various cellular activities
AMED_1147	COG2321	neutral zinc metallopeptidase
AMED_1151	COG0612	Peptidase, M16
AMED_1155	COG1175	transmembrane transport
AMED_1156	COG0395	ABC-type sugar transport system, permease component
AMED_1157	COG1486	melibiose metabolic process
AMED_1160	COG0640	Transcriptional regulator
AMED_1163	COG3265	gluconokinase activity
AMED_1165	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMED_1172	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMED_1174	COG0328	RNA-DNA hybrid ribonuclease activity
AMED_1174	COG0406	alpha-ribazole phosphatase activity
AMED_1195	COG1012	belongs to the aldehyde dehydrogenase family
AMED_1201	COG1012	belongs to the aldehyde dehydrogenase family
AMED_1202	COG3842	ATPase activity
AMED_1203	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMED_1204	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMED_1205	COG1177	transmembrane transport
AMED_1206	COG0596	Alpha beta hydrolase
AMED_1207	COG1968	undecaprenyl-diphosphatase activity
AMED_1209	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMED_1210	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMED_1210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMED_1212	COG2318	DinB family
AMED_1215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMED_1215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMED_1216	COG0653	protein targeting
AMED_1220	COG0174	glutamine synthetase
AMED_1221	COG0154	amidase activity
AMED_1222	COG1522	sequence-specific DNA binding
AMED_1224	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMED_1224	COG0519	Catalyzes the synthesis of GMP from XMP
AMED_1227	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMED_1229	COG0174	glutamine synthetase
AMED_1240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMED_1244	COG3480	Lon protease (S16) C-terminal proteolytic domain
AMED_1246	COG1615	UPF0182 protein
AMED_1250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMED_1251	COG2884	Cell division ATP-binding protein ftsE
AMED_1252	COG2177	Part of the ABC transporter FtsEX involved in
AMED_1253	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMED_1258	COG2197	response regulator
AMED_1259	COG4585	Histidine kinase
AMED_1262	COG3706	GGDEF domain
AMED_1265	COG2986	histidine ammonia-lyase
AMED_1266	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMED_1268	COG0402	S-adenosylhomocysteine deaminase activity
AMED_1269	COG1228	amidohydrolase
AMED_1270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_1277	COG4585	Histidine kinase
AMED_1283	COG1131	(ABC) transporter
AMED_1284	COG1643	Atp-dependent helicase
AMED_1285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMED_1289	COG3883	PFAM NLP P60 protein
AMED_1289	COG0791	NLP P60 protein
AMED_1292	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_1294	COG2318	DinB family
AMED_1295	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_1297	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMED_1298	COG0187	DNA topoisomerase II activity
AMED_1307	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_1308	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_1309	COG1129	ABC transporter
AMED_1310	COG1879	ABC-type sugar transport system periplasmic component
AMED_1311	COG1609	Transcriptional regulator
AMED_1312	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMED_1314	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_1318	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMED_1324	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMED_1330	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_1332	COG0017	Asparaginyl-tRNA synthetase
AMED_1336	COG0596	Alpha beta hydrolase
AMED_1341	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMED_1342	COG1486	melibiose metabolic process
AMED_1344	COG1053	succinate dehydrogenase
AMED_1345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_1346	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMED_1348	COG0596	Alpha beta hydrolase
AMED_1365	COG0697	spore germination
AMED_1366	COG1846	Transcriptional regulator
AMED_1373	COG3629	intracellular signal transduction
AMED_1373	COG3903	Transcriptional regulator
AMED_1375	COG2211	Major facilitator Superfamily
AMED_1376	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMED_1377	COG0411	ABC transporter
AMED_1378	COG0410	ABC transporter
AMED_1382	COG1309	transcriptional regulator
AMED_1388	COG1136	(ABC) transporter
AMED_1400	COG0477	Major facilitator Superfamily
AMED_1403	COG3387	PFAM Glycoside hydrolase 15-related
AMED_1404	COG1063	alcohol dehydrogenase
AMED_1408	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_1418	COG3209	COG3209 Rhs family protein
AMED_1425	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_1425	COG0604	alcohol dehydrogenase
AMED_1425	COG3321	synthase
AMED_1431	COG2018	Roadblock/LC7 domain
AMED_1436	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_1437	COG0583	DNA-binding transcription factor activity
AMED_1438	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_1440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_1447	COG0667	Aldo Keto reductase
AMED_1449	COG1595	DNA-templated transcription, initiation
AMED_1454	COG3903	Transcriptional regulator
AMED_1454	COG3629	intracellular signal transduction
AMED_1456	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AMED_1462	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMED_1463	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_1471	COG1234	tRNA 3'-trailer cleavage
AMED_1473	COG3852	Histidine kinase
AMED_1474	COG2272	Belongs to the type-B carboxylesterase lipase family
AMED_1484	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMED_1500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMED_1501	COG0765	amino acid transport
AMED_1502	COG1126	abc transporter atp-binding protein
AMED_1503	COG2964	Protein conserved in bacteria
AMED_1506	COG0596	Alpha beta hydrolase
AMED_1507	COG1131	(ABC) transporter
AMED_1513	COG2186	Transcriptional regulator
AMED_1514	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_1515	COG1129	ABC transporter
AMED_1519	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_1519	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_1520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_1523	COG1879	ABC-type sugar transport system periplasmic component
AMED_1527	COG3629	intracellular signal transduction
AMED_1527	COG3903	Transcriptional regulator
AMED_1529	COG3540	Alkaline phosphatase
AMED_1531	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AMED_1533	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AMED_1533	COG3408	Glycogen debranching enzyme
AMED_1534	COG1940	carbohydrate kinase activity
AMED_1538	COG4221	oxidoreductase activity
AMED_1539	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMED_1543	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMED_1546	COG0513	Belongs to the DEAD box helicase family
AMED_1551	COG2183	response to ionizing radiation
AMED_1554	COG2072	flavoprotein involved in K transport
AMED_1563	COG1012	belongs to the aldehyde dehydrogenase family
AMED_1563	COG2030	dehydratase
AMED_1564	COG3396	Phenylacetate-CoA oxygenase
AMED_1565	COG3460	Phenylacetate-CoA oxygenase
AMED_1566	COG3396	Phenylacetate-CoA oxygenase
AMED_1567	COG2151	metal-sulfur cluster biosynthetic enzyme
AMED_1568	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMED_1571	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMED_1578	COG0183	Belongs to the thiolase family
AMED_1581	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_1582	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMED_1583	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AMED_1584	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMED_1586	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMED_1588	COG3279	Response regulator of the LytR AlgR family
AMED_1589	COG3275	phosphorelay sensor kinase activity
AMED_1591	COG1879	ABC-type sugar transport system periplasmic component
AMED_1592	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_1595	COG1609	Transcriptional regulator
AMED_1596	COG3537	Alpha-1,2-mannosidase
AMED_1597	COG3537	Alpha-1,2-mannosidase
AMED_1599	COG1846	Transcriptional regulator
AMED_1604	COG0058	SHG alpha-glucan phosphorylase activity
AMED_1609	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_1613	COG1119	ATPase activity
AMED_1614	COG1024	Enoyl-CoA hydratase
AMED_1615	COG2226	methyltransferase
AMED_1619	COG3979	chitinase
AMED_1621	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_1628	COG0667	Aldo Keto reductase
AMED_1629	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_1630	COG0791	NLP P60 protein
AMED_1630	COG3883	PFAM NLP P60 protein
AMED_1631	COG1957	nucleoside hydrolase
AMED_1632	COG0110	maltose O-acetyltransferase activity
AMED_1647	COG3250	beta-galactosidase activity
AMED_1648	COG0386	Belongs to the glutathione peroxidase family
AMED_1650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMED_1652	COG1307	EDD domain protein, DegV family
AMED_1654	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMED_1658	COG2197	response regulator
AMED_1661	COG0482	sulfurtransferase activity
AMED_1665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMED_1669	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMED_1672	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMED_1673	COG0154	amidase activity
AMED_1674	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMED_1679	COG0673	inositol 2-dehydrogenase activity
AMED_1681	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMED_1683	COG0129	dihydroxy-acid dehydratase activity
AMED_1686	COG0440	acetolactate synthase activity
AMED_1687	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMED_1695	COG1404	Belongs to the peptidase S8 family
AMED_1696	COG0473	3-isopropylmalate dehydrogenase activity
AMED_1697	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMED_1698	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMED_1702	COG3629	intracellular signal transduction
AMED_1702	COG3903	Transcriptional regulator
AMED_1712	COG0776	regulation of translation
AMED_1714	COG0420	3'-5' exonuclease activity
AMED_1715	COG0419	ATPase involved in DNA repair
AMED_1716	COG0419	ATPase involved in DNA repair
AMED_1723	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMED_1724	COG0066	3-isopropylmalate dehydratase activity
AMED_1726	COG3903	Transcriptional regulator
AMED_1726	COG3629	intracellular signal transduction
AMED_1731	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMED_1733	COG0252	asparaginase activity
AMED_1735	COG1477	protein flavinylation
AMED_1738	COG0745	RESPONSE REGULATOR receiver
AMED_1739	COG2205	protein histidine kinase activity
AMED_1741	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_1747	COG3345	alpha-galactosidase
AMED_1748	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMED_1749	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMED_1751	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMED_1752	COG1461	Dihydroxyacetone kinase
AMED_1758	COG1404	Belongs to the peptidase S8 family
AMED_1759	COG5433	transposase activity
AMED_1761	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AMED_1775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMED_1780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMED_1782	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_1783	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_1785	COG0542	response to heat
AMED_1786	COG4249	Peptidase C14 caspase catalytic subunit p20
AMED_1786	COG2319	Wd-40 repeat
AMED_1787	COG3973	AAA domain
AMED_1788	COG0742	ribosomal rna small subunit methyltransferase
AMED_1789	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMED_1795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMED_1796	COG0571	ribonuclease III activity
AMED_1798	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMED_1802	COG3386	PFAM SMP-30 Gluconolaconase
AMED_1808	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMED_1809	COG1012	belongs to the aldehyde dehydrogenase family
AMED_1813	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMED_1813	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMED_1814	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMED_1815	COG0509	glycine decarboxylation via glycine cleavage system
AMED_1816	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMED_1817	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMED_1818	COG1760	l-serine dehydratase
AMED_1819	COG2442	InterPro IPR007367
AMED_1821	COG2186	Transcriptional regulator
AMED_1822	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMED_1824	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_1830	COG0789	Transcriptional regulator
AMED_1832	COG2814	Major facilitator Superfamily
AMED_1833	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMED_1834	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_1835	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_1837	COG1129	ABC transporter
AMED_1838	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_1839	COG2186	Transcriptional regulator
AMED_1849	COG1929	Belongs to the glycerate kinase type-1 family
AMED_1850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMED_1852	COG1940	carbohydrate kinase activity
AMED_1853	COG1653	transport
AMED_1855	COG0395	ABC-type sugar transport system, permease component
AMED_1856	COG3345	alpha-galactosidase
AMED_1857	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMED_1858	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMED_1859	COG0183	Belongs to the thiolase family
AMED_1860	COG3485	protocatechuate 3,4-dioxygenase
AMED_1861	COG3485	protocatechuate 3,4-dioxygenase
AMED_1862	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMED_1864	COG1414	Transcriptional regulator
AMED_1865	COG0746	molybdenum cofactor guanylyltransferase activity
AMED_1866	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMED_1874	COG3706	GGDEF domain
AMED_1876	COG0667	Aldo Keto reductase
AMED_1881	COG3962	Belongs to the TPP enzyme family
AMED_1882	COG3718	enzyme involved in inositol metabolism
AMED_1884	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMED_1888	COG1082	Xylose isomerase domain protein TIM barrel
AMED_1890	COG0673	inositol 2-dehydrogenase activity
AMED_1891	COG0367	asparagine synthase
AMED_1893	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMED_1894	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMED_1895	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMED_1902	COG1254	Belongs to the acylphosphatase family
AMED_1905	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMED_1906	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMED_1910	COG1414	Transcriptional regulator
AMED_1918	COG3835	regulator
AMED_1922	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMED_1923	COG3345	alpha-galactosidase
AMED_1924	COG1309	transcriptional regulator
AMED_1930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMED_1931	COG4266	Belongs to the allantoicase family
AMED_1933	COG1832	CoA-binding protein
AMED_1938	COG1595	DNA-templated transcription, initiation
AMED_1943	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMED_1947	COG3706	GGDEF domain
AMED_1948	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_1949	COG1309	transcriptional regulator
AMED_1951	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMED_1953	COG1132	(ABC) transporter
AMED_1958	COG0228	four-way junction DNA binding
AMED_1962	COG0336	Belongs to the RNA methyltransferase TrmD family
AMED_1963	COG0335	large ribosomal subunit rRNA binding
AMED_1964	COG0681	Belongs to the peptidase S26 family
AMED_1965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMED_1967	COG0792	nuclease activity
AMED_1968	COG0606	chelatase, subunit chli
AMED_1971	COG1191	sigma factor activity
AMED_1973	COG0052	Belongs to the universal ribosomal protein uS2 family
AMED_1974	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMED_1975	COG0528	UMP kinase activity
AMED_1976	COG0233	cytoplasmic translational termination
AMED_1980	COG1695	Transcriptional regulator
AMED_1981	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMED_1982	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMED_1983	COG1120	ATPase activity
AMED_1984	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AMED_1985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMED_1987	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMED_1997	COG0402	S-adenosylhomocysteine deaminase activity
AMED_2000	COG0402	S-adenosylhomocysteine deaminase activity
AMED_2008	COG0789	Transcriptional regulator
AMED_2012	COG3795	YCII-related domain
AMED_2016	COG1476	TRANSCRIPTIONal
AMED_2018	COG3795	YCII-related domain
AMED_2019	COG4941	Belongs to the sigma-70 factor family
AMED_2023	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMED_2025	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_2031	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMED_2034	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMED_2036	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMED_2038	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMED_2044	COG0454	-acetyltransferase
AMED_2044	COG0456	acetyltransferase
AMED_2051	COG2186	Transcriptional regulator
AMED_2058	COG0513	Belongs to the DEAD box helicase family
AMED_2066	COG0583	DNA-binding transcription factor activity
AMED_2068	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMED_2069	COG3022	response to hydroperoxide
AMED_2076	COG0442	prolyl-tRNA aminoacylation
AMED_2079	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMED_2088	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMED_2088	COG1017	nitric oxide dioxygenase activity
AMED_2090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMED_2091	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMED_2092	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMED_2101	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMED_2105	COG4152	abc transporter atp-binding protein
AMED_2106	COG1668	transmembrane transport
AMED_2108	COG3201	nicotinamide mononucleotide transporter
AMED_2109	COG1620	l-lactate permease
AMED_2111	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_2113	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AMED_2134	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMED_2139	COG0477	Major facilitator Superfamily
AMED_2143	COG1960	acyl-CoA dehydrogenase activity
AMED_2145	COG1104	cysteine desulfurase activity
AMED_2147	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMED_2151	COG1113	amino acid transport
AMED_2152	COG2186	Transcriptional regulator
AMED_2153	COG0587	DNA-directed DNA polymerase activity
AMED_2154	COG0477	Major facilitator Superfamily
AMED_2158	COG0586	Pfam SNARE associated Golgi protein
AMED_2159	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMED_2162	COG1309	transcriptional regulator
AMED_2164	COG0321	lipoyl(octanoyl) transferase activity
AMED_2166	COG1090	epimerase
AMED_2169	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMED_2179	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMED_2181	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMED_2181	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMED_2184	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMED_2185	COG0667	Aldo Keto reductase
AMED_2193	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMED_2200	COG1845	cytochrome c oxidase, subunit III
AMED_2201	COG2010	Cytochrome c
AMED_2203	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMED_2210	COG0438	transferase activity, transferring glycosyl groups
AMED_2213	COG2124	cytochrome p450
AMED_2214	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMED_2215	COG0659	secondary active sulfate transmembrane transporter activity
AMED_2216	COG0659	secondary active sulfate transmembrane transporter activity
AMED_2217	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMED_2220	COG0501	Belongs to the peptidase M48B family
AMED_2221	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMED_2223	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AMED_2224	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AMED_2225	COG0157	Belongs to the NadC ModD family
AMED_2226	COG1404	Belongs to the peptidase S8 family
AMED_2234	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_2238	COG1674	ftsk spoiiie
AMED_2243	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMED_2245	COG5520	Belongs to the glycosyl hydrolase 30 family
AMED_2248	COG4566	intracellular signal transduction
AMED_2249	COG2197	response regulator
AMED_2251	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMED_2253	COG0131	Imidazoleglycerol-phosphate dehydratase
AMED_2257	COG2267	carboxylic ester hydrolase activity
AMED_2258	COG2409	Drug exporters of the RND superfamily
AMED_2259	COG1309	transcriptional regulator
AMED_2260	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AMED_2262	COG3959	Transketolase, thiamine diphosphate binding domain
AMED_2263	COG3958	Transketolase
AMED_2266	COG1960	acyl-CoA dehydrogenase activity
AMED_2269	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMED_2270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMED_2282	COG0107	imidazoleglycerol-phosphate synthase activity
AMED_2284	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMED_2291	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMED_2293	COG0134	indole-3-glycerol-phosphate synthase activity
AMED_2294	COG0133	tryptophan synthase activity
AMED_2295	COG0159	tryptophan synthase activity
AMED_2296	COG0789	Transcriptional regulator
AMED_2300	COG0174	glutamine synthetase
AMED_2303	COG1473	amidohydrolase
AMED_2304	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMED_2306	COG0069	glutamate synthase activity
AMED_2306	COG0067	glutamate synthase
AMED_2306	COG0070	glutamate synthase
AMED_2310	COG0596	Alpha beta hydrolase
AMED_2311	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMED_2314	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_2316	COG2268	Band 7 protein
AMED_2318	COG0515	serine threonine protein kinase
AMED_2318	COG2815	serine threonine protein kinase
AMED_2335	COG0242	peptide deformylase activity
AMED_2336	COG1201	RNA secondary structure unwinding
AMED_2337	COG1349	DNA-binding transcription factor activity
AMED_2339	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMED_2343	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMED_2344	COG2137	regulation of response to DNA damage stimulus
AMED_2348	COG0800	Aldolase
AMED_2352	COG1053	succinate dehydrogenase
AMED_2359	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_2360	COG0765	amino acid transport
AMED_2361	COG0765	amino acid transport
AMED_2362	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMED_2363	COG1126	abc transporter atp-binding protein
AMED_2364	COG0745	RESPONSE REGULATOR receiver
AMED_2365	COG0642	Histidine kinase
AMED_2365	COG3850	Histidine kinase
AMED_2367	COG1733	regulation of RNA biosynthetic process
AMED_2380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMED_2383	COG1196	nuclear chromosome segregation
AMED_2384	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMED_2386	COG0525	valine-tRNA ligase activity
AMED_2389	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMED_2393	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMED_2394	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMED_2398	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMED_2400	COG1505	serine-type exopeptidase activity
AMED_2407	COG2936	dipeptidyl-peptidase activity
AMED_2408	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AMED_2410	COG2197	response regulator
AMED_2411	COG4585	Histidine kinase
AMED_2414	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMED_2415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AMED_2418	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMED_2421	COG1960	acyl-CoA dehydrogenase activity
AMED_2422	COG1960	acyl-CoA dehydrogenase activity
AMED_2424	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_2426	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMED_2427	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMED_2437	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_2440	COG1609	Transcriptional regulator
AMED_2443	COG0395	ABC-type sugar transport system, permease component
AMED_2444	COG2723	6-phospho-beta-galactosidase activity
AMED_2449	COG0003	Pfam Anion-transporting ATPase
AMED_2451	COG1940	carbohydrate kinase activity
AMED_2454	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMED_2459	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMED_2466	COG0640	Transcriptional regulator
AMED_2470	COG1946	Acyl-CoA thioesterase
AMED_2474	COG2197	response regulator
AMED_2475	COG1012	belongs to the aldehyde dehydrogenase family
AMED_2478	COG1960	acyl-CoA dehydrogenase activity
AMED_2479	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_2485	COG1566	PFAM secretion protein HlyD family protein
AMED_2488	COG1309	transcriptional regulator
AMED_2489	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMED_2492	COG2018	Roadblock/LC7 domain
AMED_2498	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMED_2498	COG1703	isobutyryl-CoA mutase activity
AMED_2498	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMED_2500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_2501	COG1309	transcriptional regulator
AMED_2502	COG1960	acyl-CoA dehydrogenase activity
AMED_2503	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMED_2506	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_2507	COG0748	coenzyme F420 binding
AMED_2509	COG1960	acyl-CoA dehydrogenase activity
AMED_2510	COG1960	acyl-CoA dehydrogenase activity
AMED_2511	COG2030	dehydratase
AMED_2515	COG0196	riboflavin kinase activity
AMED_2522	COG1960	acyl-CoA dehydrogenase activity
AMED_2523	COG2267	carboxylic ester hydrolase activity
AMED_2524	COG0346	lactoylglutathione lyase activity
AMED_2525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMED_2530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMED_2534	COG0583	DNA-binding transcription factor activity
AMED_2536	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMED_2548	COG1228	amidohydrolase
AMED_2549	COG0596	Alpha beta hydrolase
AMED_2550	COG0183	Belongs to the thiolase family
AMED_2551	COG2124	cytochrome p450
AMED_2554	COG1295	ribonuclease BN
AMED_2560	COG2070	2-Nitropropane dioxygenase
AMED_2563	COG2188	Transcriptional regulator
AMED_2567	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AMED_2567	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMED_2569	COG1490	D-aminoacyl-tRNA deacylase activity
AMED_2570	COG2890	protein-(glutamine-N5) methyltransferase activity
AMED_2571	COG1473	amidohydrolase
AMED_2574	COG2313	pseudouridylate synthase activity
AMED_2579	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMED_2582	COG4213	ABC transporter substrate-binding protein
AMED_2584	COG4214	carbohydrate transport
AMED_2590	COG0531	amino acid
AMED_2596	COG0366	Alpha amylase catalytic
AMED_2597	COG0366	Alpha amylase catalytic
AMED_2599	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMED_2602	COG1940	carbohydrate kinase activity
AMED_2603	COG0483	inositol monophosphate 1-phosphatase activity
AMED_2607	COG0756	dUTP diphosphatase activity
AMED_2613	COG0569	domain protein
AMED_2614	COG0531	amino acid
AMED_2615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMED_2618	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMED_2620	COG1012	belongs to the aldehyde dehydrogenase family
AMED_2621	COG0028	Belongs to the TPP enzyme family
AMED_2625	COG0745	RESPONSE REGULATOR receiver
AMED_2626	COG2205	protein histidine kinase activity
AMED_2630	COG1024	Enoyl-CoA hydratase
AMED_2630	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_2631	COG0183	Belongs to the thiolase family
AMED_2638	COG0531	amino acid
AMED_2641	COG2197	response regulator
AMED_2643	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMED_2646	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_2648	COG3220	belongs to the UPF0276 family
AMED_2651	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMED_2657	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_2658	COG0539	negative regulation of cytoplasmic translation
AMED_2660	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMED_2660	COG2508	Transcriptional regulator
AMED_2661	COG1012	belongs to the aldehyde dehydrogenase family
AMED_2662	COG0506	proline dehydrogenase activity
AMED_2663	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMED_2665	COG3795	YCII-related domain
AMED_2667	COG4941	Belongs to the sigma-70 factor family
AMED_2669	COG1793	dna ligase
AMED_2674	COG1302	Protein conserved in bacteria
AMED_2676	COG1595	DNA-templated transcription, initiation
AMED_2683	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMED_2684	COG0640	Transcriptional regulator
AMED_2686	COG2326	polyphosphate kinase activity
AMED_2689	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMED_2690	COG1993	acr, cog1993
AMED_2691	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMED_2697	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMED_2697	COG1672	PFAM Archaeal ATPase
AMED_2701	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMED_2706	COG2124	cytochrome p450
AMED_2710	COG2084	Dehydrogenase
AMED_2713	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMED_2715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMED_2716	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMED_2717	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMED_2718	COG1309	transcriptional regulator
AMED_2720	COG1073	alpha beta
AMED_2722	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMED_2724	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMED_2725	COG1263	PTS System
AMED_2725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMED_2727	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMED_2727	COG1263	PTS System
AMED_2728	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMED_2728	COG1263	PTS System
AMED_2728	COG2190	(PTS) system
AMED_2733	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMED_2734	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMED_2735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMED_2736	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMED_2737	COG0346	lactoylglutathione lyase activity
AMED_2740	COG0006	proline dipeptidase activity
AMED_2741	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMED_2742	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMED_2746	COG0540	Belongs to the ATCase OTCase family
AMED_2749	COG0505	Belongs to the CarA family
AMED_2750	COG0419	ATPase involved in DNA repair
AMED_2753	COG0284	orotidine-5'-phosphate decarboxylase activity
AMED_2755	COG0194	GDP metabolic process
AMED_2756	COG1758	RNA polymerase activity
AMED_2758	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMED_2763	COG0405	Gamma-glutamyltransferase
AMED_2764	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMED_2769	COG2197	response regulator
AMED_2770	COG4585	Histidine kinase
AMED_2773	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMED_2773	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMED_2774	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMED_2778	COG0322	excinuclease ABC activity
AMED_2779	COG1660	Displays ATPase and GTPase activities
AMED_2781	COG1481	regulation of sporulation
AMED_2782	COG0463	Glycosyl transferase, family 2
AMED_2787	COG3250	beta-galactosidase activity
AMED_2788	COG0408	coproporphyrinogen oxidase activity
AMED_2796	COG1280	lysine exporter protein (LysE YggA)
AMED_2798	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMED_2799	COG0126	phosphoglycerate kinase activity
AMED_2800	COG0149	triose-phosphate isomerase activity
AMED_2804	COG0363	glucosamine-6-phosphate deaminase activity
AMED_2807	COG0166	Belongs to the GPI family
AMED_2808	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMED_2810	COG0109	protoheme IX farnesyltransferase activity
AMED_2832	COG0396	ATPase activity
AMED_2835	COG2151	metal-sulfur cluster biosynthetic enzyme
AMED_2837	COG1742	UPF0060 membrane protein
AMED_2839	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMED_2841	COG4585	Histidine kinase
AMED_2843	COG2226	methyltransferase
AMED_2850	COG0457	Tetratricopeptide repeat
AMED_2866	COG1132	(ABC) transporter
AMED_2868	COG4821	SIS domain
AMED_2870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMED_2871	COG1316	TRANSCRIPTIONal
AMED_2872	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMED_2874	COG5001	Diguanylate cyclase
AMED_2874	COG3300	MHYT domain
AMED_2877	COG1051	belongs to the nudix hydrolase family
AMED_2879	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMED_2879	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMED_2881	COG1024	Enoyl-CoA hydratase
AMED_2886	COG1960	acyl-CoA dehydrogenase activity
AMED_2887	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMED_2890	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_2895	COG3469	chitinase activity
AMED_2905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMED_2907	COG3693	PFAM glycoside hydrolase, family 10
AMED_2911	COG1309	transcriptional regulator
AMED_2912	COG0789	Transcriptional regulator
AMED_2915	COG4249	Peptidase C14 caspase catalytic subunit p20
AMED_2915	COG2319	Wd-40 repeat
AMED_2918	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_2931	COG2197	response regulator
AMED_2945	COG0300	oxidoreductase activity
AMED_2947	COG1846	Transcriptional regulator
AMED_2950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMED_2953	COG1595	DNA-templated transcription, initiation
AMED_2957	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMED_2958	COG1799	cell septum assembly
AMED_2960	COG3599	regulation of cell shape
AMED_2962	COG0640	Transcriptional regulator
AMED_2963	COG0477	Major facilitator Superfamily
AMED_2964	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMED_2966	COG0640	Transcriptional regulator
AMED_2967	COG3263	regulation of cellular component size
AMED_2968	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMED_2970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMED_2975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_2977	COG0248	Ppx GppA phosphatase
AMED_2985	COG1940	carbohydrate kinase activity
AMED_2985	COG1846	Transcriptional regulator
AMED_2987	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AMED_2992	COG2010	Cytochrome c
AMED_2992	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMED_2997	COG1309	transcriptional regulator
AMED_2998	COG4221	oxidoreductase activity
AMED_2999	COG0667	Aldo Keto reductase
AMED_3000	COG0542	response to heat
AMED_3002	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMED_3004	COG0514	ATP-dependent DNA helicase (RecQ)
AMED_3006	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3013	COG2205	protein histidine kinase activity
AMED_3014	COG0745	RESPONSE REGULATOR receiver
AMED_3016	COG0076	glutamate decarboxylase activity
AMED_3027	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMED_3029	COG1131	(ABC) transporter
AMED_3033	COG0604	alcohol dehydrogenase
AMED_3035	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AMED_3037	COG4585	Histidine kinase
AMED_3039	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMED_3040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMED_3041	COG2080	2 iron, 2 sulfur cluster binding
AMED_3046	COG2188	Transcriptional regulator
AMED_3048	COG1063	alcohol dehydrogenase
AMED_3051	COG2172	sigma factor antagonist activity
AMED_3052	COG1366	Belongs to the anti-sigma-factor antagonist family
AMED_3053	COG1366	Belongs to the anti-sigma-factor antagonist family
AMED_3058	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3059	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMED_3061	COG3546	catalase activity
AMED_3063	COG0702	epimerase
AMED_3064	COG1733	regulation of RNA biosynthetic process
AMED_3070	COG1609	Transcriptional regulator
AMED_3072	COG1175	transmembrane transport
AMED_3073	COG0395	ABC-type sugar transport system, permease component
AMED_3077	COG0667	Aldo Keto reductase
AMED_3079	COG0667	Aldo Keto reductase
AMED_3081	COG2378	regulation of single-species biofilm formation
AMED_3083	COG1691	(AIR) carboxylase
AMED_3084	COG3875	lactate racemase activity
AMED_3085	COG3618	amidohydrolase
AMED_3086	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMED_3087	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_3090	COG1129	ABC transporter
AMED_3098	COG1609	Transcriptional regulator
AMED_3099	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3103	COG3251	PFAM MbtH domain protein
AMED_3107	COG2124	cytochrome p450
AMED_3112	COG0604	alcohol dehydrogenase
AMED_3115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMED_3126	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3130	COG3250	beta-galactosidase activity
AMED_3132	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3133	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3135	COG1309	transcriptional regulator
AMED_3138	COG1960	acyl-CoA dehydrogenase activity
AMED_3139	COG1960	acyl-CoA dehydrogenase activity
AMED_3144	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_3147	COG0395	ABC-type sugar transport system, permease component
AMED_3148	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMED_3149	COG0515	serine threonine protein kinase
AMED_3156	COG2814	Major facilitator Superfamily
AMED_3158	COG5002	protein histidine kinase activity
AMED_3159	COG0745	RESPONSE REGULATOR receiver
AMED_3162	COG1131	(ABC) transporter
AMED_3166	COG1309	transcriptional regulator
AMED_3171	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMED_3172	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_3174	COG1595	DNA-templated transcription, initiation
AMED_3178	COG0596	Alpha beta hydrolase
AMED_3180	COG0477	Major facilitator Superfamily
AMED_3189	COG0366	Alpha amylase catalytic
AMED_3193	COG1175	transmembrane transport
AMED_3196	COG1349	DNA-binding transcription factor activity
AMED_3198	COG1609	Transcriptional regulator
AMED_3199	COG2815	serine threonine protein kinase
AMED_3199	COG0515	serine threonine protein kinase
AMED_3200	COG0515	serine threonine protein kinase
AMED_3200	COG2815	serine threonine protein kinase
AMED_3203	COG0437	4 iron, 4 sulfur cluster binding
AMED_3206	COG2271	Major facilitator Superfamily
AMED_3209	COG2318	DinB family
AMED_3215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMED_3217	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_3218	COG0583	DNA-binding transcription factor activity
AMED_3220	COG1053	succinate dehydrogenase
AMED_3221	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMED_3228	COG3511	phospholipase C
AMED_3235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMED_3236	COG3938	Belongs to the proline racemase family
AMED_3238	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_3238	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_3239	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_3241	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMED_3242	COG0395	ABC-type sugar transport system, permease component
AMED_3243	COG1175	transmembrane transport
AMED_3253	COG0628	permease
AMED_3254	COG3507	Belongs to the glycosyl hydrolase 43 family
AMED_3255	COG1793	dna ligase
AMED_3255	COG3285	dna ligase
AMED_3258	COG2226	methyltransferase
AMED_3259	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMED_3267	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_3268	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMED_3269	COG1024	Enoyl-CoA hydratase
AMED_3272	COG1012	belongs to the aldehyde dehydrogenase family
AMED_3286	COG3507	Belongs to the glycosyl hydrolase 43 family
AMED_3300	COG1309	transcriptional regulator
AMED_3301	COG1595	DNA-templated transcription, initiation
AMED_3304	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3305	COG0028	Belongs to the TPP enzyme family
AMED_3309	COG2018	Roadblock/LC7 domain
AMED_3313	COG2188	Transcriptional regulator
AMED_3314	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AMED_3315	COG0395	ABC-type sugar transport system, permease component
AMED_3316	COG1175	transmembrane transport
AMED_3319	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMED_3326	COG0745	RESPONSE REGULATOR receiver
AMED_3326	COG3706	GGDEF domain
AMED_3327	COG1609	Transcriptional regulator
AMED_3335	COG3591	Belongs to the peptidase S1B family
AMED_3340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMED_3347	COG2267	carboxylic ester hydrolase activity
AMED_3353	COG2357	RelA SpoT domain protein
AMED_3358	COG1280	lysine exporter protein (LysE YggA)
AMED_3359	COG0484	heat shock protein binding
AMED_3360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMED_3365	COG2409	Drug exporters of the RND superfamily
AMED_3367	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3369	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMED_3377	COG1024	Enoyl-CoA hydratase
AMED_3381	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_3382	COG0183	Belongs to the thiolase family
AMED_3384	COG1960	acyl-CoA dehydrogenase activity
AMED_3385	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3386	COG1024	Enoyl-CoA hydratase
AMED_3387	COG1960	acyl-CoA dehydrogenase activity
AMED_3388	COG1960	acyl-CoA dehydrogenase activity
AMED_3389	COG1960	acyl-CoA dehydrogenase activity
AMED_3392	COG1802	Transcriptional regulator
AMED_3393	COG3591	Belongs to the peptidase S1B family
AMED_3393	COG1864	DNA RNA non-specific endonuclease
AMED_3396	COG1063	alcohol dehydrogenase
AMED_3397	COG2267	carboxylic ester hydrolase activity
AMED_3401	COG1309	transcriptional regulator
AMED_3402	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMED_3405	COG3345	alpha-galactosidase
AMED_3408	COG1175	transmembrane transport
AMED_3409	COG0395	ABC-type sugar transport system, permease component
AMED_3416	COG0477	Major facilitator Superfamily
AMED_3418	COG1940	carbohydrate kinase activity
AMED_3419	COG0531	amino acid
AMED_3420	COG3250	beta-galactosidase activity
AMED_3421	COG1940	carbohydrate kinase activity
AMED_3423	COG1609	Transcriptional regulator
AMED_3426	COG2124	cytochrome p450
AMED_3434	COG1846	Transcriptional regulator
AMED_3435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_3445	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3451	COG0702	epimerase
AMED_3456	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMED_3459	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_3463	COG0601	transmembrane transport
AMED_3464	COG0444	Belongs to the ABC transporter superfamily
AMED_3465	COG4608	Belongs to the ABC transporter superfamily
AMED_3467	COG0477	Major facilitator Superfamily
AMED_3472	COG0477	Major facilitator Superfamily
AMED_3474	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMED_3478	COG3507	Belongs to the glycosyl hydrolase 43 family
AMED_3481	COG1231	oxidoreductase activity
AMED_3483	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMED_3483	COG0235	Class ii aldolase
AMED_3486	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3487	COG0701	Predicted permease
AMED_3492	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3494	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3496	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3498	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMED_3505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMED_3511	COG0501	Belongs to the peptidase M48B family
AMED_3518	COG0569	domain protein
AMED_3518	COG0475	glutathione-regulated potassium exporter activity
AMED_3525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMED_3526	COG4279	zinc finger
AMED_3533	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_3539	COG0069	glutamate synthase activity
AMED_3540	COG0745	RESPONSE REGULATOR receiver
AMED_3541	COG5002	protein histidine kinase activity
AMED_3544	COG1136	(ABC) transporter
AMED_3544	COG0577	efflux transmembrane transporter activity
AMED_3545	COG1136	(ABC) transporter
AMED_3545	COG0577	efflux transmembrane transporter activity
AMED_3548	COG2814	Major facilitator Superfamily
AMED_3549	COG0596	Alpha beta hydrolase
AMED_3551	COG4585	Histidine kinase
AMED_3557	COG4585	Histidine kinase
AMED_3565	COG4221	oxidoreductase activity
AMED_3566	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AMED_3581	COG0745	RESPONSE REGULATOR receiver
AMED_3582	COG2205	protein histidine kinase activity
AMED_3586	COG0726	polysaccharide deacetylase
AMED_3610	COG4221	oxidoreductase activity
AMED_3611	COG4249	Peptidase C14 caspase catalytic subunit p20
AMED_3611	COG2319	Wd-40 repeat
AMED_3623	COG2197	response regulator
AMED_3624	COG0736	holo-[acyl-carrier-protein] synthase activity
AMED_3628	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMED_3639	COG1834	amidinotransferase
AMED_3641	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMED_3642	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMED_3643	COG2080	2 iron, 2 sulfur cluster binding
AMED_3645	COG3345	alpha-galactosidase
AMED_3652	COG1309	transcriptional regulator
AMED_3658	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3659	COG0583	DNA-binding transcription factor activity
AMED_3673	COG0583	DNA-binding transcription factor activity
AMED_3690	COG2205	protein histidine kinase activity
AMED_3697	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_3706	COG1522	sequence-specific DNA binding
AMED_3719	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMED_3721	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMED_3722	COG2080	2 iron, 2 sulfur cluster binding
AMED_3728	COG0631	protein serine/threonine phosphatase activity
AMED_3738	COG3509	depolymerase
AMED_3742	COG0601	transmembrane transport
AMED_3744	COG4608	Belongs to the ABC transporter superfamily
AMED_3746	COG1609	Transcriptional regulator
AMED_3747	COG4124	Belongs to the glycosyl hydrolase 26 family
AMED_3749	COG1846	Transcriptional regulator
AMED_3749	COG1940	carbohydrate kinase activity
AMED_3751	COG1960	acyl-CoA dehydrogenase activity
AMED_3752	COG2207	Transcriptional regulator
AMED_3766	COG0745	RESPONSE REGULATOR receiver
AMED_3767	COG2205	protein histidine kinase activity
AMED_3769	COG2755	lipolytic protein G-D-S-L family
AMED_3769	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMED_3774	COG2267	carboxylic ester hydrolase activity
AMED_3775	COG2226	methyltransferase
AMED_3777	COG0640	Transcriptional regulator
AMED_3784	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AMED_3786	COG0375	protein maturation
AMED_3788	COG0409	Hydrogenase expression formation protein
AMED_3797	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMED_3799	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMED_3806	COG3629	intracellular signal transduction
AMED_3806	COG3903	Transcriptional regulator
AMED_3807	COG0596	Alpha beta hydrolase
AMED_3808	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_3808	COG1024	Enoyl-CoA hydratase
AMED_3809	COG1733	regulation of RNA biosynthetic process
AMED_3815	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3816	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_3817	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3818	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3824	COG0411	ABC transporter
AMED_3826	COG1024	Enoyl-CoA hydratase
AMED_3827	COG1960	acyl-CoA dehydrogenase activity
AMED_3828	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3829	COG1946	Acyl-CoA thioesterase
AMED_3831	COG1024	Enoyl-CoA hydratase
AMED_3832	COG1960	acyl-CoA dehydrogenase activity
AMED_3833	COG1012	belongs to the aldehyde dehydrogenase family
AMED_3835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_3836	COG0183	Belongs to the thiolase family
AMED_3844	COG1946	Acyl-CoA thioesterase
AMED_3848	COG1960	acyl-CoA dehydrogenase activity
AMED_3852	COG0183	Belongs to the thiolase family
AMED_3855	COG0183	Belongs to the thiolase family
AMED_3856	COG1024	Enoyl-CoA hydratase
AMED_3859	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3862	COG1024	Enoyl-CoA hydratase
AMED_3864	COG1960	acyl-CoA dehydrogenase activity
AMED_3865	COG1960	acyl-CoA dehydrogenase activity
AMED_3866	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3871	COG1960	acyl-CoA dehydrogenase activity
AMED_3874	COG1012	belongs to the aldehyde dehydrogenase family
AMED_3875	COG1960	acyl-CoA dehydrogenase activity
AMED_3876	COG1960	acyl-CoA dehydrogenase activity
AMED_3877	COG1024	Enoyl-CoA hydratase
AMED_3878	COG2188	Transcriptional regulator
AMED_3879	COG0300	oxidoreductase activity
AMED_3880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMED_3886	COG1309	transcriptional regulator
AMED_3888	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMED_3889	COG3629	intracellular signal transduction
AMED_3889	COG3903	Transcriptional regulator
AMED_3893	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMED_3893	COG1017	nitric oxide dioxygenase activity
AMED_3894	COG1940	carbohydrate kinase activity
AMED_3894	COG1846	Transcriptional regulator
AMED_3897	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMED_3899	COG0531	amino acid
AMED_3900	COG3387	PFAM Glycoside hydrolase 15-related
AMED_3901	COG2814	Major facilitator Superfamily
AMED_3903	COG2197	response regulator
AMED_3910	COG0628	permease
AMED_3913	COG1486	melibiose metabolic process
AMED_3914	COG0395	ABC-type sugar transport system, permease component
AMED_3918	COG1349	DNA-binding transcription factor activity
AMED_3919	COG2222	sugar isomerase
AMED_3922	COG1105	Belongs to the carbohydrate kinase PfkB family
AMED_3935	COG0596	Alpha beta hydrolase
AMED_3937	COG1024	Enoyl-CoA hydratase
AMED_3937	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMED_3938	COG3903	Transcriptional regulator
AMED_3938	COG3629	intracellular signal transduction
AMED_3940	COG1132	(ABC) transporter
AMED_3946	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_3950	COG4221	oxidoreductase activity
AMED_3951	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_3952	COG0395	ABC-type sugar transport system, permease component
AMED_3953	COG3833	ABC-type maltose transport systems, permease component
AMED_3960	COG2124	cytochrome p450
AMED_3961	COG2175	clavaminate synthase activity
AMED_3962	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_3962	COG3321	synthase
AMED_3962	COG4221	oxidoreductase activity
AMED_3962	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3963	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_3964	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_3973	COG1940	carbohydrate kinase activity
AMED_3974	COG1940	carbohydrate kinase activity
AMED_3974	COG1846	Transcriptional regulator
AMED_3975	COG1129	ABC transporter
AMED_3976	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_3978	COG0673	inositol 2-dehydrogenase activity
AMED_3980	COG0604	alcohol dehydrogenase
AMED_3996	COG1064	alcohol dehydrogenase
AMED_3997	COG1309	transcriptional regulator
AMED_3998	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_4001	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMED_4002	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_4006	COG2508	Transcriptional regulator
AMED_4007	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMED_4009	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMED_4010	COG0463	Glycosyl transferase, family 2
AMED_4012	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_4014	COG3629	intracellular signal transduction
AMED_4015	COG0583	DNA-binding transcription factor activity
AMED_4017	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4019	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4020	COG1846	Transcriptional regulator
AMED_4021	COG3903	Transcriptional regulator
AMED_4021	COG3629	intracellular signal transduction
AMED_4022	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMED_4025	COG2197	response regulator
AMED_4027	COG0577	efflux transmembrane transporter activity
AMED_4027	COG1136	(ABC) transporter
AMED_4033	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMED_4039	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMED_4042	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4044	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMED_4045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMED_4046	COG3629	intracellular signal transduction
AMED_4046	COG3903	Transcriptional regulator
AMED_4047	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMED_4051	COG3509	depolymerase
AMED_4052	COG2205	protein histidine kinase activity
AMED_4053	COG0745	RESPONSE REGULATOR receiver
AMED_4054	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMED_4056	COG0583	DNA-binding transcription factor activity
AMED_4061	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_4067	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMED_4085	COG0395	ABC-type sugar transport system, permease component
AMED_4088	COG1609	Transcriptional regulator
AMED_4094	COG0653	protein targeting
AMED_4103	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_4105	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMED_4109	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMED_4110	COG1012	belongs to the aldehyde dehydrogenase family
AMED_4111	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMED_4118	COG3661	Belongs to the glycosyl hydrolase 67 family
AMED_4121	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4130	COG2201	protein-glutamate methylesterase activity
AMED_4131	COG2201	protein-glutamate methylesterase activity
AMED_4135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMED_4144	COG0477	Major facilitator Superfamily
AMED_4147	COG2318	DinB family
AMED_4148	COG1793	dna ligase
AMED_4154	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AMED_4156	COG2814	Major facilitator Superfamily
AMED_4158	COG2855	membrane
AMED_4160	COG0583	DNA-binding transcription factor activity
AMED_4166	COG0439	Biotin carboxylase
AMED_4174	COG0477	Major facilitator Superfamily
AMED_4179	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_4184	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMED_4190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMED_4197	COG1793	dna ligase
AMED_4197	COG3285	dna ligase
AMED_4203	COG2267	carboxylic ester hydrolase activity
AMED_4209	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMED_4212	COG3634	alkyl hydroperoxide reductase activity
AMED_4216	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMED_4228	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMED_4231	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMED_4233	COG2890	protein-(glutamine-N5) methyltransferase activity
AMED_4237	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMED_4238	COG2124	cytochrome p450
AMED_4240	COG2201	protein-glutamate methylesterase activity
AMED_4244	COG0515	serine threonine protein kinase
AMED_4244	COG2815	serine threonine protein kinase
AMED_4246	COG0326	Molecular chaperone. Has ATPase activity
AMED_4248	COG3794	PFAM blue (type 1) copper domain protein
AMED_4261	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4264	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMED_4269	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMED_4271	COG0300	oxidoreductase activity
AMED_4272	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMED_4272	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMED_4273	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMED_4274	COG2192	nodulation
AMED_4275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMED_4278	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AMED_4278	COG0463	Glycosyl transferase, family 2
AMED_4279	COG0297	glycogen (starch) synthase activity
AMED_4288	COG1295	ribonuclease BN
AMED_4288	COG1959	2 iron, 2 sulfur cluster binding
AMED_4293	COG0723	plastoquinol--plastocyanin reductase activity
AMED_4293	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMED_4294	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMED_4296	COG2890	protein-(glutamine-N5) methyltransferase activity
AMED_4299	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMED_4301	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMED_4303	COG1982	Orn Lys Arg decarboxylase major
AMED_4307	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMED_4312	COG0596	Alpha beta hydrolase
AMED_4317	COG3835	regulator
AMED_4322	COG3284	Transcriptional regulator
AMED_4331	COG0459	protein refolding
AMED_4336	COG0596	Alpha beta hydrolase
AMED_4337	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4338	COG0435	Glutathione S-transferase
AMED_4340	COG2353	YceI-like domain
AMED_4341	COG1309	transcriptional regulator
AMED_4344	COG0395	ABC-type sugar transport system, permease component
AMED_4347	COG1609	Transcriptional regulator
AMED_4348	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_4350	COG2124	cytochrome p450
AMED_4352	COG1716	ATPase activity
AMED_4352	COG5001	Diguanylate cyclase
AMED_4355	COG0247	lactate metabolic process
AMED_4355	COG2181	nitrate reductase activity
AMED_4356	COG1716	ATPase activity
AMED_4358	COG0477	Major facilitator Superfamily
AMED_4360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMED_4365	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_4367	COG4991	sh3 domain protein
AMED_4384	COG0302	gtp cyclohydrolase
AMED_4387	COG1609	Transcriptional regulator
AMED_4391	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4394	COG1686	Belongs to the peptidase S11 family
AMED_4396	COG1609	Transcriptional regulator
AMED_4397	COG1879	ABC-type sugar transport system periplasmic component
AMED_4399	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_4400	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_4404	COG2160	L-arabinose isomerase activity
AMED_4406	COG1129	ABC transporter
AMED_4407	COG4214	carbohydrate transport
AMED_4409	COG1609	Transcriptional regulator
AMED_4411	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMED_4412	COG1414	Transcriptional regulator
AMED_4414	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMED_4415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMED_4417	COG0137	argininosuccinate synthase activity
AMED_4426	COG0277	FAD linked oxidase domain protein
AMED_4427	COG1609	Transcriptional regulator
AMED_4429	COG1653	transport
AMED_4430	COG1175	transmembrane transport
AMED_4431	COG0395	ABC-type sugar transport system, permease component
AMED_4433	COG0673	inositol 2-dehydrogenase activity
AMED_4434	COG0673	inositol 2-dehydrogenase activity
AMED_4436	COG3866	Pectate lyase
AMED_4442	COG3903	Transcriptional regulator
AMED_4442	COG3629	intracellular signal transduction
AMED_4445	COG0589	response to stress
AMED_4446	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMED_4458	COG1090	epimerase
AMED_4464	COG0297	glycogen (starch) synthase activity
AMED_4469	COG3250	beta-galactosidase activity
AMED_4472	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMED_4481	COG0477	Major facilitator Superfamily
AMED_4482	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_4482	COG3321	synthase
AMED_4483	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_4486	COG0300	oxidoreductase activity
AMED_4487	COG1819	glycosyl
AMED_4489	COG1793	dna ligase
AMED_4489	COG3285	dna ligase
AMED_4491	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMED_4494	COG2267	carboxylic ester hydrolase activity
AMED_4497	COG3903	Transcriptional regulator
AMED_4497	COG3629	intracellular signal transduction
AMED_4498	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMED_4500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMED_4500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMED_4500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMED_4503	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMED_4507	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_4508	COG1609	Transcriptional regulator
AMED_4511	COG0395	ABC-type sugar transport system, permease component
AMED_4513	COG1609	Transcriptional regulator
AMED_4517	COG1278	Cold shock
AMED_4518	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMED_4528	COG0387	Pfam Sodium calcium exchanger
AMED_4529	COG0583	DNA-binding transcription factor activity
AMED_4530	COG0028	Belongs to the TPP enzyme family
AMED_4538	COG1609	Transcriptional regulator
AMED_4539	COG1129	ABC transporter
AMED_4540	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_4541	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_4543	COG3254	rhamnose metabolic process
AMED_4545	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4545	COG3347	Dehydrogenase
AMED_4547	COG1070	Carbohydrate kinase
AMED_4548	COG2197	response regulator
AMED_4549	COG4585	Histidine kinase
AMED_4552	COG3250	beta-galactosidase activity
AMED_4563	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMED_4564	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMED_4567	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMED_4570	COG0045	succinate-CoA ligase (ADP-forming) activity
AMED_4572	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_4573	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMED_4573	COG1042	CoA-binding domain protein
AMED_4573	COG0045	succinate-CoA ligase (ADP-forming) activity
AMED_4574	COG2223	nitrite transmembrane transporter activity
AMED_4575	COG1802	Transcriptional regulator
AMED_4576	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMED_4577	COG3383	formate dehydrogenase (NAD+) activity
AMED_4578	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMED_4579	COG1034	ATP synthesis coupled electron transport
AMED_4580	COG3622	Belongs to the hyi family
AMED_4581	COG2084	Dehydrogenase
AMED_4582	COG3960	tartronate-semialdehyde synthase activity
AMED_4585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMED_4586	COG0590	tRNA wobble adenosine to inosine editing
AMED_4587	COG2252	PERMEase
AMED_4589	COG1929	Belongs to the glycerate kinase type-1 family
AMED_4600	COG2066	Belongs to the glutaminase family
AMED_4603	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMED_4606	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMED_4607	COG0596	Alpha beta hydrolase
AMED_4609	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_4612	COG3285	dna ligase
AMED_4612	COG1793	dna ligase
AMED_4613	COG0183	Belongs to the thiolase family
AMED_4614	COG1733	regulation of RNA biosynthetic process
AMED_4622	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_4623	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_4624	COG1609	Transcriptional regulator
AMED_4626	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMED_4627	COG2267	carboxylic ester hydrolase activity
AMED_4634	COG0667	Aldo Keto reductase
AMED_4635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_4636	COG1968	undecaprenyl-diphosphatase activity
AMED_4638	COG0339	signal peptide processing
AMED_4639	COG0740	serine-type endopeptidase activity
AMED_4640	COG0039	L-malate dehydrogenase activity
AMED_4647	COG3537	Alpha-1,2-mannosidase
AMED_4655	COG0747	negative chemotaxis
AMED_4656	COG0601	transmembrane transport
AMED_4658	COG4172	Belongs to the ABC transporter superfamily
AMED_4661	COG1619	proteins homologs of microcin C7 resistance protein MccF
AMED_4662	COG4946	Tricorn protease homolog
AMED_4662	COG0823	Involved in the tonB-independent uptake of proteins
AMED_4662	COG1506	peptidase
AMED_4674	COG0477	Major facilitator Superfamily
AMED_4678	COG0640	Transcriptional regulator
AMED_4689	COG4941	Belongs to the sigma-70 factor family
AMED_4702	COG4941	Belongs to the sigma-70 factor family
AMED_4704	COG2124	cytochrome p450
AMED_4708	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMED_4711	COG1309	transcriptional regulator
AMED_4713	COG1960	acyl-CoA dehydrogenase activity
AMED_4714	COG1309	transcriptional regulator
AMED_4717	COG1396	sequence-specific DNA binding
AMED_4720	COG0640	Transcriptional regulator
AMED_4722	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AMED_4727	COG1435	thymidine kinase activity
AMED_4729	COG0494	nUDIX hydrolase
AMED_4731	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMED_4732	COG0463	Glycosyl transferase, family 2
AMED_4734	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMED_4738	COG4977	sequence-specific DNA binding
AMED_4739	COG1733	regulation of RNA biosynthetic process
AMED_4743	COG3903	Transcriptional regulator
AMED_4743	COG3629	intracellular signal transduction
AMED_4750	COG4865	methylaspartate mutase activity
AMED_4751	COG0017	Asparaginyl-tRNA synthetase
AMED_4752	COG0069	glutamate synthase activity
AMED_4755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMED_4765	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_4770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_4775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_4787	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_4788	COG2186	Transcriptional regulator
AMED_4789	COG0395	ABC-type sugar transport system, permease component
AMED_4790	COG1175	transmembrane transport
AMED_4791	COG3293	Transposase
AMED_4795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMED_4797	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMED_4798	COG4865	methylaspartate mutase activity
AMED_4800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_4809	COG0789	Transcriptional regulator
AMED_4819	COG2124	cytochrome p450
AMED_4826	COG2197	response regulator
AMED_4827	COG2197	response regulator
AMED_4829	COG0823	Involved in the tonB-independent uptake of proteins
AMED_4850	COG0402	S-adenosylhomocysteine deaminase activity
AMED_4851	COG1414	Transcriptional regulator
AMED_4852	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_4854	COG3485	protocatechuate 3,4-dioxygenase
AMED_4858	COG3979	chitinase
AMED_4860	COG1136	(ABC) transporter
AMED_4864	COG4221	oxidoreductase activity
AMED_4865	COG0583	DNA-binding transcription factor activity
AMED_4867	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMED_4876	COG4552	Acetyltransferase involved in intracellular survival and related
AMED_4880	COG1597	lipid kinase activity
AMED_4882	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMED_4884	COG2378	regulation of single-species biofilm formation
AMED_4886	COG1733	regulation of RNA biosynthetic process
AMED_4888	COG4221	oxidoreductase activity
AMED_4890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMED_4893	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMED_4894	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMED_4901	COG0640	Transcriptional regulator
AMED_4904	COG0697	spore germination
AMED_4905	COG1222	aaa ATPase
AMED_4910	COG0517	IMP dehydrogenase activity
AMED_4910	COG1994	Peptidase M50
AMED_4913	COG1192	Involved in chromosome partitioning
AMED_4914	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMED_4915	COG0140	phosphoribosyl-ATP diphosphatase activity
AMED_4918	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMED_4919	COG0646	methionine synthase
AMED_4919	COG1410	methionine synthase
AMED_4926	COG2814	Major facilitator Superfamily
AMED_4929	COG0488	(ABC) transporter
AMED_4930	COG0215	cysteine-tRNA ligase activity
AMED_4931	COG0789	Transcriptional regulator
AMED_4932	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMED_4933	COG4867	von Willebrand factor, type A
AMED_4940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMED_4942	COG0477	Major facilitator Superfamily
AMED_4943	COG0745	RESPONSE REGULATOR receiver
AMED_4944	COG2205	protein histidine kinase activity
AMED_4947	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMED_4949	COG2304	oxidoreductase activity
AMED_4951	COG0714	Associated with various cellular activities
AMED_4952	COG0746	molybdenum cofactor guanylyltransferase activity
AMED_4953	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMED_4954	COG3883	PFAM NLP P60 protein
AMED_4954	COG0791	NLP P60 protein
AMED_4955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMED_4956	COG1285	pathogenesis
AMED_4958	COG1309	transcriptional regulator
AMED_4961	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AMED_4963	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMED_4964	COG3572	ergothioneine biosynthetic process
AMED_4966	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMED_4967	COG2267	carboxylic ester hydrolase activity
AMED_4972	COG1309	transcriptional regulator
AMED_4980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMED_4983	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMED_4983	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMED_4987	COG0789	Transcriptional regulator
AMED_4990	COG1716	ATPase activity
AMED_4996	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMED_4997	COG1024	Enoyl-CoA hydratase
AMED_4998	COG2267	carboxylic ester hydrolase activity
AMED_4999	COG1648	precorrin-2 dehydrogenase activity
AMED_4999	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMED_5002	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMED_5003	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMED_5005	COG0254	rRNA binding
AMED_5013	COG2211	Major facilitator Superfamily
AMED_5014	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_5021	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_5023	COG1116	anion transmembrane transporter activity
AMED_5024	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMED_5025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMED_5026	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMED_5030	COG1132	(ABC) transporter
AMED_5033	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMED_5035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMED_5036	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMED_5037	COG1120	ATPase activity
AMED_5039	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AMED_5046	COG0488	(ABC) transporter
AMED_5054	COG3293	Transposase
AMED_5067	COG3250	beta-galactosidase activity
AMED_5071	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_5073	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_5074	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMED_5076	COG1116	anion transmembrane transporter activity
AMED_5077	COG2205	protein histidine kinase activity
AMED_5078	COG0745	RESPONSE REGULATOR receiver
AMED_5084	COG1846	Transcriptional regulator
AMED_5085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMED_5087	COG0028	Belongs to the TPP enzyme family
AMED_5088	COG1073	alpha beta
AMED_5089	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5090	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMED_5092	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_5096	COG1129	ABC transporter
AMED_5097	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMED_5101	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMED_5106	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMED_5107	COG0463	Glycosyl transferase, family 2
AMED_5114	COG4221	oxidoreductase activity
AMED_5117	COG1921	L-seryl-tRNASec selenium transferase activity
AMED_5118	COG0709	Synthesizes selenophosphate from selenide and ATP
AMED_5124	COG2367	Beta-lactamase
AMED_5125	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMED_5128	COG2267	carboxylic ester hydrolase activity
AMED_5135	COG0596	Alpha beta hydrolase
AMED_5136	COG1309	transcriptional regulator
AMED_5146	COG2409	Drug exporters of the RND superfamily
AMED_5151	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMED_5152	COG0019	diaminopimelate decarboxylase activity
AMED_5161	COG2201	protein-glutamate methylesterase activity
AMED_5162	COG4585	Histidine kinase
AMED_5164	COG2197	response regulator
AMED_5167	COG1324	tolerance protein
AMED_5178	COG2814	Major facilitator Superfamily
AMED_5185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMED_5186	COG0667	Aldo Keto reductase
AMED_5191	COG5297	Belongs to the glycosyl hydrolase family 6
AMED_5192	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMED_5193	COG4733	cellulase activity
AMED_5193	COG5297	Belongs to the glycosyl hydrolase family 6
AMED_5197	COG0395	ABC-type sugar transport system, permease component
AMED_5199	COG0129	dihydroxy-acid dehydratase activity
AMED_5202	COG1573	uracil-dna glycosylase
AMED_5203	COG3285	dna ligase
AMED_5203	COG1793	dna ligase
AMED_5205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMED_5225	COG0583	DNA-binding transcription factor activity
AMED_5226	COG0019	diaminopimelate decarboxylase activity
AMED_5231	COG0477	Major facilitator Superfamily
AMED_5232	COG0456	acetyltransferase
AMED_5234	COG4104	PAAR repeat-containing protein
AMED_5234	COG3209	COG3209 Rhs family protein
AMED_5256	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMED_5262	COG0456	acetyltransferase
AMED_5263	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMED_5266	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMED_5270	COG2018	Roadblock/LC7 domain
AMED_5271	COG2205	protein histidine kinase activity
AMED_5278	COG3629	intracellular signal transduction
AMED_5278	COG3903	Transcriptional regulator
AMED_5283	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMED_5287	COG1024	Enoyl-CoA hydratase
AMED_5287	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_5293	COG0402	S-adenosylhomocysteine deaminase activity
AMED_5294	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMED_5295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMED_5296	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMED_5297	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMED_5298	COG1862	Preprotein translocase
AMED_5299	COG2255	four-way junction helicase activity
AMED_5300	COG0632	four-way junction helicase activity
AMED_5301	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMED_5304	COG0217	transcriptional regulatory protein
AMED_5305	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AMED_5308	COG1396	sequence-specific DNA binding
AMED_5309	COG0644	oxidoreductase
AMED_5310	COG1960	acyl-CoA dehydrogenase activity
AMED_5314	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AMED_5316	COG0277	FAD linked oxidase domain protein
AMED_5318	COG3608	succinylglutamate desuccinylase aspartoacylase
AMED_5318	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMED_5322	COG0438	transferase activity, transferring glycosyl groups
AMED_5327	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMED_5328	COG0778	Nitroreductase
AMED_5332	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMED_5333	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMED_5334	COG0701	Predicted permease
AMED_5338	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMED_5343	COG1473	amidohydrolase
AMED_5346	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMED_5351	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_5353	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_5366	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMED_5367	COG0395	ABC-type sugar transport system, permease component
AMED_5368	COG1175	transmembrane transport
AMED_5371	COG2072	flavoprotein involved in K transport
AMED_5374	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5383	COG2211	Major facilitator Superfamily
AMED_5384	COG1802	Transcriptional regulator
AMED_5392	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMED_5400	COG3483	tryptophan 2,3-dioxygenase activity
AMED_5403	COG2197	response regulator
AMED_5404	COG4585	Histidine kinase
AMED_5406	COG1131	(ABC) transporter
AMED_5408	COG3510	cephalosporin hydroxylase
AMED_5409	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_5411	COG1819	glycosyl
AMED_5413	COG1819	glycosyl
AMED_5421	COG3629	intracellular signal transduction
AMED_5422	COG1819	glycosyl
AMED_5423	COG0574	Belongs to the PEP-utilizing enzyme family
AMED_5423	COG3848	Pyruvate phosphate dikinase
AMED_5426	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5430	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5432	COG2867	negative regulation of translational initiation
AMED_5433	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMED_5434	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMED_5435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMED_5436	COG0662	Cupin 2, conserved barrel domain protein
AMED_5439	COG3104	oligopeptide transport
AMED_5440	COG2345	Transcriptional regulator
AMED_5441	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_5445	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5454	COG3209	COG3209 Rhs family protein
AMED_5460	COG0659	secondary active sulfate transmembrane transporter activity
AMED_5462	COG0589	response to stress
AMED_5466	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMED_5469	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMED_5470	COG1042	CoA-binding domain protein
AMED_5470	COG0045	succinate-CoA ligase (ADP-forming) activity
AMED_5470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMED_5474	COG1271	oxidase subunit
AMED_5475	COG1294	oxidase, subunit
AMED_5476	COG4988	ABC transporter
AMED_5477	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AMED_5479	COG2239	Acts as a magnesium transporter
AMED_5486	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMED_5491	COG4585	Histidine kinase
AMED_5492	COG2197	response regulator
AMED_5496	COG4585	Histidine kinase
AMED_5497	COG2197	response regulator
AMED_5508	COG2197	response regulator
AMED_5515	COG0681	Belongs to the peptidase S26 family
AMED_5516	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5529	COG0405	Gamma-glutamyltransferase
AMED_5530	COG3706	GGDEF domain
AMED_5539	COG1216	Glycosyl transferase, family 2
AMED_5540	COG1215	transferase activity, transferring glycosyl groups
AMED_5542	COG1132	(ABC) transporter
AMED_5545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_5546	COG0596	Alpha beta hydrolase
AMED_5557	COG2814	Major facilitator Superfamily
AMED_5559	COG3629	intracellular signal transduction
AMED_5559	COG3903	Transcriptional regulator
AMED_5575	COG0330	HflC and HflK could
AMED_5592	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMED_5604	COG0297	glycogen (starch) synthase activity
AMED_5609	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5610	COG1309	transcriptional regulator
AMED_5611	COG4941	Belongs to the sigma-70 factor family
AMED_5612	COG4941	Belongs to the sigma-70 factor family
AMED_5616	COG3250	beta-galactosidase activity
AMED_5617	COG0583	DNA-binding transcription factor activity
AMED_5624	COG0515	serine threonine protein kinase
AMED_5625	COG1595	DNA-templated transcription, initiation
AMED_5626	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMED_5635	COG0596	Alpha beta hydrolase
AMED_5636	COG0596	Alpha beta hydrolase
AMED_5638	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMED_5641	COG1672	PFAM Archaeal ATPase
AMED_5641	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMED_5642	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5647	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5654	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMED_5666	COG2205	protein histidine kinase activity
AMED_5667	COG0745	RESPONSE REGULATOR receiver
AMED_5668	COG1216	Glycosyl transferase, family 2
AMED_5669	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMED_5675	COG1609	Transcriptional regulator
AMED_5677	COG1309	transcriptional regulator
AMED_5688	COG4941	Belongs to the sigma-70 factor family
AMED_5692	COG1335	isochorismatase
AMED_5697	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_5698	COG1309	transcriptional regulator
AMED_5701	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AMED_5702	COG1414	Transcriptional regulator
AMED_5703	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5707	COG1278	Cold shock
AMED_5710	COG0300	oxidoreductase activity
AMED_5712	COG3795	YCII-related domain
AMED_5715	COG3263	regulation of cellular component size
AMED_5716	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMED_5718	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMED_5726	COG0745	RESPONSE REGULATOR receiver
AMED_5727	COG5000	phosphorelay sensor kinase activity
AMED_5727	COG5002	protein histidine kinase activity
AMED_5729	COG1733	regulation of RNA biosynthetic process
AMED_5731	COG1846	Transcriptional regulator
AMED_5732	COG0038	chloride channel
AMED_5740	COG0437	4 iron, 4 sulfur cluster binding
AMED_5747	COG2116	formate transmembrane transporter activity
AMED_5749	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AMED_5753	COG0531	amino acid
AMED_5754	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMED_5757	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMED_5758	COG2080	2 iron, 2 sulfur cluster binding
AMED_5760	COG0667	Aldo Keto reductase
AMED_5762	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5772	COG1609	Transcriptional regulator
AMED_5773	COG1609	Transcriptional regulator
AMED_5777	COG1609	Transcriptional regulator
AMED_5781	COG2207	Transcriptional regulator
AMED_5781	COG1917	Cupin 2, conserved barrel domain protein
AMED_5806	COG3293	Transposase
AMED_5810	COG1857	crispr-associated protein
AMED_5827	COG5297	Belongs to the glycosyl hydrolase family 6
AMED_5827	COG4733	cellulase activity
AMED_5833	COG0154	amidase activity
AMED_5834	COG0789	Transcriptional regulator
AMED_5835	COG0640	Transcriptional regulator
AMED_5841	COG0673	inositol 2-dehydrogenase activity
AMED_5846	COG1653	transport
AMED_5852	COG3842	ATPase activity
AMED_5854	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMED_5855	COG0028	Belongs to the TPP enzyme family
AMED_5859	COG2197	response regulator
AMED_5861	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMED_5863	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMED_5865	COG0702	epimerase
AMED_5867	COG0583	DNA-binding transcription factor activity
AMED_5869	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMED_5882	COG0300	oxidoreductase activity
AMED_5883	COG4221	oxidoreductase activity
AMED_5884	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMED_5885	COG0406	alpha-ribazole phosphatase activity
AMED_5885	COG0328	RNA-DNA hybrid ribonuclease activity
AMED_5896	COG2318	DinB family
AMED_5897	COG0667	Aldo Keto reductase
AMED_5900	COG2267	carboxylic ester hydrolase activity
AMED_5903	COG3903	Transcriptional regulator
AMED_5903	COG3629	intracellular signal transduction
AMED_5915	COG4974	Belongs to the 'phage' integrase family
AMED_5916	COG1012	belongs to the aldehyde dehydrogenase family
AMED_5926	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMED_5934	COG0515	serine threonine protein kinase
AMED_5934	COG2815	serine threonine protein kinase
AMED_5937	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMED_5943	COG3511	phospholipase C
AMED_5954	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_5963	COG0714	Associated with various cellular activities
AMED_5965	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AMED_5966	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMED_5968	COG1733	regulation of RNA biosynthetic process
AMED_5970	COG5492	domain, Protein
AMED_5973	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_5974	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMED_5976	COG1414	Transcriptional regulator
AMED_5977	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMED_5980	COG0726	polysaccharide deacetylase
AMED_5997	COG1160	GTP binding
AMED_6003	COG0475	glutathione-regulated potassium exporter activity
AMED_6004	COG2936	dipeptidyl-peptidase activity
AMED_6005	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMED_6007	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMED_6014	COG0504	CTP synthase activity
AMED_6016	COG1802	Transcriptional regulator
AMED_6017	COG1953	Uracil, thiamine, allantoin
AMED_6024	COG1063	alcohol dehydrogenase
AMED_6027	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMED_6030	COG0647	UMP catabolic process
AMED_6032	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMED_6033	COG2094	Belongs to the DNA glycosylase MPG family
AMED_6037	COG0165	Argininosuccinate lyase
AMED_6038	COG0137	argininosuccinate synthase activity
AMED_6039	COG1438	arginine binding
AMED_6040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMED_6041	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMED_6042	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMED_6043	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMED_6044	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMED_6048	COG0596	Alpha beta hydrolase
AMED_6050	COG0072	phenylalanine-tRNA ligase activity
AMED_6050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMED_6051	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMED_6053	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMED_6054	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMED_6055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMED_6064	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMED_6065	COG2610	gluconate transmembrane transporter activity
AMED_6072	COG4565	transcriptional regulatory protein
AMED_6073	COG3290	protein histidine kinase activity
AMED_6074	COG1301	dicarboxylic acid transport
AMED_6084	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMED_6090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMED_6091	COG0328	RNA-DNA hybrid ribonuclease activity
AMED_6092	COG3012	SEC-C Motif Domain Protein
AMED_6094	COG3250	beta-galactosidase activity
AMED_6095	COG2272	Belongs to the type-B carboxylesterase lipase family
AMED_6098	COG0406	alpha-ribazole phosphatase activity
AMED_6102	COG1609	Transcriptional regulator
AMED_6107	COG0823	Involved in the tonB-independent uptake of proteins
AMED_6107	COG4946	Tricorn protease homolog
AMED_6107	COG1506	peptidase
AMED_6109	COG1131	(ABC) transporter
AMED_6113	COG1024	Enoyl-CoA hydratase
AMED_6122	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMED_6122	COG0237	dephospho-CoA kinase activity
AMED_6127	COG0539	negative regulation of cytoplasmic translation
AMED_6128	COG2226	methyltransferase
AMED_6132	COG1511	domain protein
AMED_6133	COG1309	transcriptional regulator
AMED_6134	COG2207	Transcriptional regulator
AMED_6135	COG0604	alcohol dehydrogenase
AMED_6140	COG0583	DNA-binding transcription factor activity
AMED_6143	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMED_6191	COG4585	Histidine kinase
AMED_6192	COG2197	response regulator
AMED_6196	COG2197	response regulator
AMED_6197	COG4585	Histidine kinase
AMED_6201	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMED_6202	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMED_6206	COG1454	alcohol dehydrogenase
AMED_6208	COG1012	belongs to the aldehyde dehydrogenase family
AMED_6212	COG0596	Alpha beta hydrolase
AMED_6216	COG4977	sequence-specific DNA binding
AMED_6217	COG0596	Alpha beta hydrolase
AMED_6219	COG0300	oxidoreductase activity
AMED_6227	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMED_6236	COG3251	PFAM MbtH domain protein
AMED_6247	COG2814	Major facilitator Superfamily
AMED_6250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMED_6251	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMED_6253	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMED_6254	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMED_6258	COG0768	penicillin binding
AMED_6260	COG0275	rRNA processing
AMED_6261	COG2001	Belongs to the MraZ family
AMED_6267	COG0714	Associated with various cellular activities
AMED_6269	COG1305	Transglutaminase-like
AMED_6273	COG1192	Involved in chromosome partitioning
AMED_6274	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMED_6275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMED_6277	COG0167	dihydroorotate dehydrogenase activity
AMED_6281	COG1396	sequence-specific DNA binding
AMED_6282	COG1546	Belongs to the CinA family
AMED_6282	COG1058	Belongs to the CinA family
AMED_6284	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMED_6285	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AMED_6291	COG1674	ftsk spoiiie
AMED_6293	COG0655	NAD(P)H dehydrogenase (quinone) activity
AMED_6297	COG1113	amino acid transport
AMED_6299	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMED_6300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMED_6308	COG3214	Protein conserved in bacteria
AMED_6316	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMED_6317	COG0612	Peptidase, M16
AMED_6318	COG1185	polyribonucleotide nucleotidyltransferase activity
AMED_6319	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMED_6323	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMED_6328	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMED_6330	COG2268	Band 7 protein
AMED_6333	COG2226	methyltransferase
AMED_6340	COG0195	Participates in both transcription termination and antitermination
AMED_6341	COG0779	Required for maturation of 30S ribosomal subunits
AMED_6347	COG3226	Transcriptional regulator
AMED_6349	COG4585	Histidine kinase
AMED_6350	COG2197	response regulator
AMED_6352	COG1733	regulation of RNA biosynthetic process
AMED_6354	COG1309	transcriptional regulator
AMED_6355	COG2936	dipeptidyl-peptidase activity
AMED_6358	COG0745	RESPONSE REGULATOR receiver
AMED_6359	COG5002	protein histidine kinase activity
AMED_6361	COG3629	intracellular signal transduction
AMED_6361	COG3903	Transcriptional regulator
AMED_6365	COG0583	DNA-binding transcription factor activity
AMED_6366	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_6367	COG1024	Enoyl-CoA hydratase
AMED_6369	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_6370	COG1960	acyl-CoA dehydrogenase activity
AMED_6371	COG1316	TRANSCRIPTIONal
AMED_6377	COG0583	DNA-binding transcription factor activity
AMED_6381	COG2124	cytochrome p450
AMED_6389	COG3903	Transcriptional regulator
AMED_6389	COG3629	intracellular signal transduction
AMED_6400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMED_6408	COG1595	DNA-templated transcription, initiation
AMED_6414	COG3507	Belongs to the glycosyl hydrolase 43 family
AMED_6417	COG4941	Belongs to the sigma-70 factor family
AMED_6418	COG3795	YCII-related domain
AMED_6419	COG2267	carboxylic ester hydrolase activity
AMED_6420	COG1309	transcriptional regulator
AMED_6421	COG0604	alcohol dehydrogenase
AMED_6426	COG0443	Heat shock 70 kDa protein
AMED_6429	COG1228	amidohydrolase
AMED_6437	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMED_6443	COG2197	response regulator
AMED_6449	COG2755	lipolytic protein G-D-S-L family
AMED_6449	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMED_6457	COG3629	intracellular signal transduction
AMED_6457	COG3903	Transcriptional regulator
AMED_6463	COG0667	Aldo Keto reductase
AMED_6469	COG1960	acyl-CoA dehydrogenase activity
AMED_6472	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_6475	COG0596	Alpha beta hydrolase
AMED_6476	COG2197	response regulator
AMED_6481	COG0477	Major facilitator Superfamily
AMED_6491	COG4585	Histidine kinase
AMED_6492	COG2197	response regulator
AMED_6495	COG0586	Pfam SNARE associated Golgi protein
AMED_6497	COG1968	undecaprenyl-diphosphatase activity
AMED_6505	COG4585	Histidine kinase
AMED_6506	COG2197	response regulator
AMED_6510	COG1309	transcriptional regulator
AMED_6511	COG0702	epimerase
AMED_6512	COG0702	epimerase
AMED_6517	COG2814	Major facilitator Superfamily
AMED_6522	COG4977	sequence-specific DNA binding
AMED_6533	COG1120	ATPase activity
AMED_6534	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMED_6558	COG0243	molybdopterin cofactor binding
AMED_6568	COG0028	Belongs to the TPP enzyme family
AMED_6569	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_6570	COG0247	lactate metabolic process
AMED_6570	COG0277	FAD linked oxidase domain protein
AMED_6574	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMED_6575	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AMED_6577	COG1659	Linocin_M18 bacteriocin protein
AMED_6581	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AMED_6585	COG4106	trans-aconitate 2-methyltransferase activity
AMED_6588	COG1595	DNA-templated transcription, initiation
AMED_6591	COG0477	Major facilitator Superfamily
AMED_6595	COG2318	DinB family
AMED_6598	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AMED_6600	COG2197	response regulator
AMED_6601	COG4585	Histidine kinase
AMED_6603	COG1131	(ABC) transporter
AMED_6604	COG0423	glycine-tRNA ligase activity
AMED_6612	COG0701	Predicted permease
AMED_6614	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMED_6615	COG1381	Involved in DNA repair and RecF pathway recombination
AMED_6621	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMED_6624	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMED_6626	COG0537	adenosine 5'-monophosphoramidase activity
AMED_6628	COG0484	heat shock protein binding
AMED_6629	COG1420	regulation of RNA biosynthetic process
AMED_6634	COG0667	Aldo Keto reductase
AMED_6641	COG2205	protein histidine kinase activity
AMED_6642	COG0745	RESPONSE REGULATOR receiver
AMED_6643	COG1953	Uracil, thiamine, allantoin
AMED_6645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMED_6663	COG0326	Molecular chaperone. Has ATPase activity
AMED_6666	COG1024	Enoyl-CoA hydratase
AMED_6667	COG2732	(Barnase) inhibitor
AMED_6668	COG4290	ribonuclease
AMED_6670	COG0604	alcohol dehydrogenase
AMED_6672	COG0531	amino acid
AMED_6673	COG2070	2-Nitropropane dioxygenase
AMED_6685	COG0268	Binds directly to 16S ribosomal RNA
AMED_6687	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMED_6689	COG2333	competence protein COMEC
AMED_6689	COG0658	competence protein
AMED_6691	COG1307	EDD domain protein, DegV family
AMED_6693	COG0406	alpha-ribazole phosphatase activity
AMED_6694	COG0799	negative regulation of ribosome biogenesis
AMED_6695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMED_6697	COG0477	Major facilitator Superfamily
AMED_6698	COG0018	arginyl-trna synthetase
AMED_6702	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_6704	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMED_6705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMED_6706	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMED_6707	COG1530	ribonuclease E activity
AMED_6707	COG1530	ribonuclease E activity
AMED_6711	COG1131	(ABC) transporter
AMED_6714	COG0105	UTP biosynthetic process
AMED_6716	COG2366	antibiotic biosynthetic process
AMED_6718	COG0285	dihydrofolate synthase activity
AMED_6723	COG0583	DNA-binding transcription factor activity
AMED_6724	COG0525	valine-tRNA ligase activity
AMED_6726	COG1846	Transcriptional regulator
AMED_6727	COG0477	Major facilitator Superfamily
AMED_6730	COG1316	TRANSCRIPTIONal
AMED_6733	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMED_6740	COG0740	serine-type endopeptidase activity
AMED_6741	COG0740	serine-type endopeptidase activity
AMED_6742	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMED_6744	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMED_6746	COG2205	protein histidine kinase activity
AMED_6747	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMED_6759	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMED_6767	COG3629	intracellular signal transduction
AMED_6767	COG3903	Transcriptional regulator
AMED_6769	COG3537	Alpha-1,2-mannosidase
AMED_6770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMED_6771	COG3559	Exporter of polyketide antibiotics
AMED_6772	COG1131	(ABC) transporter
AMED_6773	COG1309	transcriptional regulator
AMED_6775	COG1940	carbohydrate kinase activity
AMED_6779	COG2814	Major facilitator Superfamily
AMED_6785	COG0693	protein deglycase activity
AMED_6786	COG2208	phosphoserine phosphatase activity
AMED_6787	COG5002	protein histidine kinase activity
AMED_6787	COG0784	Response regulator, receiver
AMED_6789	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMED_6792	COG1396	sequence-specific DNA binding
AMED_6796	COG0583	DNA-binding transcription factor activity
AMED_6798	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_6800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_6803	COG1733	regulation of RNA biosynthetic process
AMED_6804	COG3345	alpha-galactosidase
AMED_6809	COG0459	protein refolding
AMED_6811	COG0698	ribose 5-phosphate isomerase
AMED_6814	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMED_6817	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AMED_6821	COG0668	transmembrane transport
AMED_6823	COG0366	Alpha amylase catalytic
AMED_6827	COG2902	Dehydrogenase
AMED_6830	COG3336	cytochrome c oxidase
AMED_6833	COG0738	Major facilitator superfamily
AMED_6836	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMED_6837	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMED_6841	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMED_6849	COG0477	Major facilitator Superfamily
AMED_6850	COG0596	Alpha beta hydrolase
AMED_6854	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMED_6859	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMED_6869	COG2124	cytochrome p450
AMED_6876	COG1733	regulation of RNA biosynthetic process
AMED_6877	COG4941	Belongs to the sigma-70 factor family
AMED_6878	COG3795	YCII-related domain
AMED_6880	COG0009	L-threonylcarbamoyladenylate synthase
AMED_6883	COG2197	response regulator
AMED_6885	COG1917	Cupin 2, conserved barrel domain protein
AMED_6885	COG4977	sequence-specific DNA binding
AMED_6886	COG2197	response regulator
AMED_6887	COG4585	Histidine kinase
AMED_6890	COG1733	regulation of RNA biosynthetic process
AMED_6896	COG1937	Protein conserved in bacteria
AMED_6901	COG4221	oxidoreductase activity
AMED_6904	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMED_6913	COG0745	RESPONSE REGULATOR receiver
AMED_6914	COG2205	protein histidine kinase activity
AMED_6916	COG1609	Transcriptional regulator
AMED_6923	COG0367	asparagine synthase
AMED_6925	COG1940	carbohydrate kinase activity
AMED_6929	COG0583	DNA-binding transcription factor activity
AMED_6937	COG1609	Transcriptional regulator
AMED_6944	COG0531	amino acid
AMED_6945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMED_6951	COG3835	regulator
AMED_6956	COG1021	2,3-dihydroxybenzoate-AMP ligase
AMED_6958	COG1733	regulation of RNA biosynthetic process
AMED_6960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMED_6961	COG0583	DNA-binding transcription factor activity
AMED_6970	COG1024	Enoyl-CoA hydratase
AMED_6982	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_6985	COG1643	Atp-dependent helicase
AMED_6988	COG3268	Saccharopine dehydrogenase
AMED_6989	COG2072	flavoprotein involved in K transport
AMED_6992	COG1796	DNA polymerase
AMED_6992	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMED_6994	COG1802	Transcriptional regulator
AMED_6999	COG3706	GGDEF domain
AMED_7001	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AMED_7004	COG4941	Belongs to the sigma-70 factor family
AMED_7008	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMED_7011	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_7013	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMED_7014	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMED_7015	COG0235	Class ii aldolase
AMED_7015	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMED_7019	COG1695	Transcriptional regulator
AMED_7021	COG3959	Transketolase, thiamine diphosphate binding domain
AMED_7022	COG1309	transcriptional regulator
AMED_7023	COG0277	FAD linked oxidase domain protein
AMED_7023	COG0247	lactate metabolic process
AMED_7025	COG2197	response regulator
AMED_7027	COG0410	ABC transporter
AMED_7029	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMED_7030	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMED_7033	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMED_7034	COG3537	Alpha-1,2-mannosidase
AMED_7035	COG1739	Uncharacterized protein family UPF0029
AMED_7036	COG0069	glutamate synthase activity
AMED_7036	COG0067	glutamate synthase
AMED_7036	COG0070	glutamate synthase
AMED_7038	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMED_7044	COG1492	cobalamin metabolic process
AMED_7045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMED_7047	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMED_7048	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AMED_7049	COG2378	regulation of single-species biofilm formation
AMED_7052	COG1797	cobyrinic acid a,c-diamide synthase activity
AMED_7059	COG0778	Nitroreductase
AMED_7065	COG1131	(ABC) transporter
AMED_7067	COG1476	TRANSCRIPTIONal
AMED_7070	COG3469	chitinase activity
AMED_7074	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMED_7079	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMED_7081	COG0433	COG0433 Predicted ATPase
AMED_7082	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMED_7083	COG0477	Major facilitator Superfamily
AMED_7120	COG1960	acyl-CoA dehydrogenase activity
AMED_7122	COG0022	dehydrogenase e1 component
AMED_7123	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_7124	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7125	COG1024	Enoyl-CoA hydratase
AMED_7129	COG0477	Major facilitator Superfamily
AMED_7133	COG2186	Transcriptional regulator
AMED_7134	COG1012	belongs to the aldehyde dehydrogenase family
AMED_7135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_7138	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMED_7147	COG1309	transcriptional regulator
AMED_7149	COG0604	alcohol dehydrogenase
AMED_7158	COG1960	acyl-CoA dehydrogenase activity
AMED_7159	COG1960	acyl-CoA dehydrogenase activity
AMED_7161	COG2186	Transcriptional regulator
AMED_7164	COG0604	alcohol dehydrogenase
AMED_7164	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7164	COG3321	synthase
AMED_7165	COG1960	acyl-CoA dehydrogenase activity
AMED_7166	COG1960	acyl-CoA dehydrogenase activity
AMED_7169	COG1024	Enoyl-CoA hydratase
AMED_7174	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_7177	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7183	COG1414	Transcriptional regulator
AMED_7185	COG2267	carboxylic ester hydrolase activity
AMED_7188	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7189	COG0259	pyridoxamine-phosphate oxidase activity
AMED_7190	COG0183	Belongs to the thiolase family
AMED_7192	COG1024	Enoyl-CoA hydratase
AMED_7193	COG1960	acyl-CoA dehydrogenase activity
AMED_7197	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_7199	COG1024	Enoyl-CoA hydratase
AMED_7201	COG1024	Enoyl-CoA hydratase
AMED_7205	COG1024	Enoyl-CoA hydratase
AMED_7207	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMED_7209	COG1012	belongs to the aldehyde dehydrogenase family
AMED_7213	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMED_7220	COG1335	isochorismatase
AMED_7223	COG1309	transcriptional regulator
AMED_7225	COG0022	dehydrogenase e1 component
AMED_7231	COG1063	alcohol dehydrogenase
AMED_7233	COG4585	Histidine kinase
AMED_7234	COG2197	response regulator
AMED_7238	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_7239	COG2271	Major facilitator Superfamily
AMED_7246	COG0235	Class ii aldolase
AMED_7247	COG0477	Major facilitator Superfamily
AMED_7248	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMED_7254	COG0673	inositol 2-dehydrogenase activity
AMED_7255	COG2211	Major facilitator Superfamily
AMED_7256	COG1609	Transcriptional regulator
AMED_7257	COG1653	transport
AMED_7259	COG0395	ABC-type sugar transport system, permease component
AMED_7261	COG0596	Alpha beta hydrolase
AMED_7263	COG0596	Alpha beta hydrolase
AMED_7266	COG2084	Dehydrogenase
AMED_7268	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMED_7269	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMED_7271	COG0189	ligase activity
AMED_7274	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_7275	COG0625	glutathione transferase activity
AMED_7277	COG2271	Major facilitator Superfamily
AMED_7278	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMED_7280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_7315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMED_7323	COG2856	Zn peptidase
AMED_7328	COG0702	epimerase
AMED_7334	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMED_7335	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMED_7336	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_7337	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7338	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMED_7338	COG2169	Transcriptional regulator
AMED_7357	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMED_7364	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMED_7365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMED_7369	COG1960	acyl-CoA dehydrogenase activity
AMED_7373	COG0154	amidase activity
AMED_7376	COG0583	DNA-binding transcription factor activity
AMED_7384	COG1131	(ABC) transporter
AMED_7386	COG3345	alpha-galactosidase
AMED_7395	COG0438	transferase activity, transferring glycosyl groups
AMED_7399	COG0297	glycogen (starch) synthase activity
AMED_7400	COG0438	transferase activity, transferring glycosyl groups
AMED_7403	COG0463	Glycosyl transferase, family 2
AMED_7410	COG3250	beta-galactosidase activity
AMED_7411	COG3401	FG-GAP repeat protein
AMED_7417	COG0395	ABC-type sugar transport system, permease component
AMED_7418	COG1175	transmembrane transport
AMED_7426	COG0596	Alpha beta hydrolase
AMED_7427	COG2770	Histidine kinase
AMED_7427	COG2208	phosphoserine phosphatase activity
AMED_7429	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMED_7431	COG2226	methyltransferase
AMED_7433	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMED_7441	COG0667	Aldo Keto reductase
AMED_7442	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_7446	COG0587	DNA-directed DNA polymerase activity
AMED_7447	COG4941	Belongs to the sigma-70 factor family
AMED_7448	COG3795	YCII-related domain
AMED_7450	COG1982	Orn Lys Arg decarboxylase major
AMED_7453	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMED_7455	COG1725	Transcriptional regulator
AMED_7456	COG1131	(ABC) transporter
AMED_7460	COG3509	depolymerase
AMED_7463	COG1528	Iron-storage protein
AMED_7468	COG2018	Roadblock/LC7 domain
AMED_7473	COG1764	response to oxidative stress
AMED_7475	COG2267	carboxylic ester hydrolase activity
AMED_7478	COG0667	Aldo Keto reductase
AMED_7479	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMED_7486	COG0395	ABC-type sugar transport system, permease component
AMED_7487	COG1175	transmembrane transport
AMED_7488	COG1609	Transcriptional regulator
AMED_7493	COG0604	alcohol dehydrogenase
AMED_7499	COG1595	DNA-templated transcription, initiation
AMED_7501	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_7502	COG0129	dihydroxy-acid dehydratase activity
AMED_7503	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMED_7515	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMED_7522	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMED_7524	COG2226	methyltransferase
AMED_7525	COG2508	Transcriptional regulator
AMED_7527	COG3655	Transcriptional regulator
AMED_7536	COG4981	capsule polysaccharide biosynthetic process
AMED_7541	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_7542	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMED_7554	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMED_7557	COG3226	Transcriptional regulator
AMED_7569	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMED_7574	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_7577	COG0745	RESPONSE REGULATOR receiver
AMED_7578	COG5002	protein histidine kinase activity
AMED_7583	COG0515	serine threonine protein kinase
AMED_7583	COG2815	serine threonine protein kinase
AMED_7587	COG0640	Transcriptional regulator
AMED_7589	COG2837	iron assimilation
AMED_7590	COG3511	phospholipase C
AMED_7593	COG0784	Response regulator, receiver
AMED_7594	COG4251	negative regulation of phosphorylation
AMED_7595	COG0745	RESPONSE REGULATOR receiver
AMED_7612	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMED_7617	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMED_7633	COG1309	transcriptional regulator
AMED_7639	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AMED_7640	COG1309	transcriptional regulator
AMED_7644	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_7645	COG3383	formate dehydrogenase (NAD+) activity
AMED_7646	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_7648	COG1733	regulation of RNA biosynthetic process
AMED_7655	COG2814	Major facilitator Superfamily
AMED_7669	COG0706	membrane insertase activity
AMED_7671	COG1408	metallophosphoesterase
AMED_7673	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMED_7674	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMED_7679	COG2018	Roadblock/LC7 domain
AMED_7683	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7685	COG3706	GGDEF domain
AMED_7688	COG1316	TRANSCRIPTIONal
AMED_7695	COG4977	sequence-specific DNA binding
AMED_7696	COG0667	Aldo Keto reductase
AMED_7697	COG2207	Transcriptional regulator
AMED_7703	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMED_7704	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMED_7705	COG1234	tRNA 3'-trailer cleavage
AMED_7706	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMED_7709	COG1794	racemase activity, acting on amino acids and derivatives
AMED_7710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMED_7715	COG3191	aminopeptidase activity
AMED_7718	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMED_7719	COG1335	isochorismatase
AMED_7720	COG0800	Aldolase
AMED_7722	COG1268	BioY protein
AMED_7728	COG0560	Phosphoserine phosphatase
AMED_7728	COG3830	Belongs to the UPF0237 family
AMED_7729	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMED_7731	COG2267	carboxylic ester hydrolase activity
AMED_7735	COG2801	Transposase and inactivated derivatives
AMED_7738	COG0626	cystathionine gamma-synthase activity
AMED_7739	COG1522	sequence-specific DNA binding
AMED_7741	COG1522	sequence-specific DNA binding
AMED_7748	COG2376	Dihydroxyacetone kinase
AMED_7754	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AMED_7755	COG1051	belongs to the nudix hydrolase family
AMED_7758	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AMED_7759	COG4977	sequence-specific DNA binding
AMED_7760	COG1335	isochorismatase
AMED_7764	COG1280	lysine exporter protein (LysE YggA)
AMED_7765	COG1280	lysine exporter protein (LysE YggA)
AMED_7767	COG0702	epimerase
AMED_7768	COG3631	Ketosteroid isomerase-related protein
AMED_7769	COG1309	transcriptional regulator
AMED_7772	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMED_7774	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMED_7775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMED_7776	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMED_7777	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMED_7778	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMED_7779	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMED_7780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMED_7781	COG0356	it plays a direct role in the translocation of protons across the membrane
AMED_7783	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMED_7786	COG2890	protein-(glutamine-N5) methyltransferase activity
AMED_7787	COG0463	Glycosyl transferase, family 2
AMED_7791	COG0254	rRNA binding
AMED_7793	COG0083	homoserine kinase activity
AMED_7794	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMED_7795	COG0460	homoserine dehydrogenase
AMED_7796	COG0019	diaminopimelate decarboxylase activity
AMED_7797	COG0018	arginyl-trna synthetase
AMED_7804	COG0596	Alpha beta hydrolase
AMED_7816	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMED_7818	COG3629	intracellular signal transduction
AMED_7818	COG3903	Transcriptional regulator
AMED_7819	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMED_7819	COG2124	cytochrome p450
AMED_7823	COG3345	alpha-galactosidase
AMED_7828	COG3693	PFAM glycoside hydrolase, family 10
AMED_7842	COG5433	transposase activity
AMED_7852	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMED_7853	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMED_7857	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_7859	COG0145	ligase activity
AMED_7864	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AMED_7867	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMED_7870	COG0154	amidase activity
AMED_7876	COG0473	3-isopropylmalate dehydrogenase activity
AMED_7880	COG0667	Aldo Keto reductase
AMED_7884	COG0028	Belongs to the TPP enzyme family
AMED_7889	COG4585	Histidine kinase
AMED_7890	COG2197	response regulator
AMED_7891	COG2409	Drug exporters of the RND superfamily
AMED_7892	COG3537	Alpha-1,2-mannosidase
AMED_7893	COG1024	Enoyl-CoA hydratase
AMED_7893	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_7894	COG0183	Belongs to the thiolase family
AMED_7895	COG1309	transcriptional regulator
AMED_7903	COG1960	acyl-CoA dehydrogenase activity
AMED_7904	COG1960	acyl-CoA dehydrogenase activity
AMED_7914	COG4221	oxidoreductase activity
AMED_7920	COG1960	acyl-CoA dehydrogenase activity
AMED_7922	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMED_7928	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMED_7931	COG0346	lactoylglutathione lyase activity
AMED_7935	COG2226	methyltransferase
AMED_7936	COG2508	Transcriptional regulator
AMED_7936	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMED_7939	COG0686	Belongs to the AlaDH PNT family
AMED_7941	COG2205	protein histidine kinase activity
AMED_7943	COG0745	RESPONSE REGULATOR receiver
AMED_7946	COG1132	(ABC) transporter
AMED_7949	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMED_7949	COG0567	Dehydrogenase, E1 component
AMED_7951	COG1216	Glycosyl transferase, family 2
AMED_7952	COG2223	nitrite transmembrane transporter activity
AMED_7954	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_7957	COG1174	glycine betaine transport
AMED_7958	COG1174	glycine betaine transport
AMED_7959	COG1125	glycine betaine transport
AMED_7959	COG0517	IMP dehydrogenase activity
AMED_7962	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMED_7964	COG1846	Transcriptional regulator
AMED_7967	COG0406	alpha-ribazole phosphatase activity
AMED_7970	COG1597	lipid kinase activity
AMED_7975	COG1595	DNA-templated transcription, initiation
AMED_7976	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMED_7978	COG2135	peptidase activity
AMED_7984	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMED_7985	COG1011	Hydrolase
AMED_7988	COG0653	protein targeting
AMED_7989	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AMED_7991	COG5401	PFAM Sporulation and spore germination
AMED_7992	COG5000	phosphorelay sensor kinase activity
AMED_7992	COG5002	protein histidine kinase activity
AMED_7993	COG0745	RESPONSE REGULATOR receiver
AMED_7995	COG1414	Transcriptional regulator
AMED_8009	COG0531	amino acid
AMED_8011	COG3903	Transcriptional regulator
AMED_8011	COG3629	intracellular signal transduction
AMED_8012	COG1482	cell wall glycoprotein biosynthetic process
AMED_8014	COG2835	tetraacyldisaccharide 4'-kinase activity
AMED_8015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMED_8023	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMED_8026	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMED_8027	COG0601	transmembrane transport
AMED_8029	COG0747	negative chemotaxis
AMED_8033	COG0180	Tryptophanyl-tRNA synthetase
AMED_8035	COG2205	protein histidine kinase activity
AMED_8036	COG0745	RESPONSE REGULATOR receiver
AMED_8038	COG1131	(ABC) transporter
AMED_8040	COG3842	ATPase activity
AMED_8041	COG4149	molybdate abc transporter
AMED_8043	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMED_8047	COG0012	GTP binding
AMED_8050	COG0419	ATPase involved in DNA repair
AMED_8051	COG0420	3'-5' exonuclease activity
AMED_8054	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMED_8056	COG1570	exodeoxyribonuclease VII activity
AMED_8058	COG1722	exodeoxyribonuclease VII activity
AMED_8061	COG0492	ferredoxin-NADP+ reductase activity
AMED_8062	COG0114	fumarate hydratase activity
AMED_8064	COG1793	dna ligase
AMED_8067	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMED_8074	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMED_8079	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AMED_8085	COG1331	Highly conserved protein containing a thioredoxin domain
AMED_8087	COG2890	protein-(glutamine-N5) methyltransferase activity
AMED_8088	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMED_8090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMED_8092	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMED_8093	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMED_8095	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AMED_8101	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMED_8108	COG0183	Belongs to the thiolase family
AMED_8119	COG3629	intracellular signal transduction
AMED_8119	COG3903	Transcriptional regulator
AMED_8120	COG2723	6-phospho-beta-galactosidase activity
AMED_8122	COG1175	transmembrane transport
AMED_8125	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_8126	COG0667	Aldo Keto reductase
AMED_8128	COG0477	Major facilitator Superfamily
AMED_8136	COG2207	Transcriptional regulator
AMED_8139	COG5297	Belongs to the glycosyl hydrolase family 6
AMED_8142	COG2205	protein histidine kinase activity
AMED_8143	COG0148	phosphopyruvate hydratase activity
AMED_8145	COG1132	(ABC) transporter
AMED_8165	COG1595	DNA-templated transcription, initiation
AMED_8166	COG2815	serine threonine protein kinase
AMED_8166	COG0515	serine threonine protein kinase
AMED_8173	COG1191	sigma factor activity
AMED_8188	COG1515	deoxyribonuclease V activity
AMED_8191	COG4608	Belongs to the ABC transporter superfamily
AMED_8192	COG0444	Belongs to the ABC transporter superfamily
AMED_8200	COG0148	phosphopyruvate hydratase activity
AMED_8204	COG0672	)-iron permease
AMED_8205	COG2822	iron ion transport
AMED_8206	COG2837	iron assimilation
AMED_8212	COG1131	(ABC) transporter
AMED_8222	COG0586	Pfam SNARE associated Golgi protein
AMED_8224	COG4585	Histidine kinase
AMED_8225	COG2197	response regulator
AMED_8226	COG2133	pyrroloquinoline quinone binding
AMED_8230	COG1051	belongs to the nudix hydrolase family
AMED_8231	COG1309	transcriptional regulator
AMED_8234	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMED_8240	COG0193	aminoacyl-tRNA hydrolase activity
AMED_8243	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_8244	COG0488	(ABC) transporter
AMED_8246	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMED_8247	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMED_8248	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMED_8249	COG3583	domain protein
AMED_8250	COG0084	hydrolase, TatD family'
AMED_8251	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMED_8262	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMED_8263	COG2815	serine threonine protein kinase
AMED_8263	COG0515	serine threonine protein kinase
AMED_8267	COG2258	MOSC domain
AMED_8270	COG1595	DNA-templated transcription, initiation
AMED_8278	COG5001	Diguanylate cyclase
AMED_8280	COG2124	cytochrome p450
AMED_8281	COG1192	Involved in chromosome partitioning
AMED_8286	COG0745	RESPONSE REGULATOR receiver
AMED_8287	COG2205	protein histidine kinase activity
AMED_8288	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMED_8289	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMED_8291	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMED_8292	COG1733	regulation of RNA biosynthetic process
AMED_8293	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AMED_8294	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMED_8294	COG3433	isochorismatase activity
AMED_8294	COG2226	methyltransferase
AMED_8297	COG1280	lysine exporter protein (LysE YggA)
AMED_8299	COG0515	serine threonine protein kinase
AMED_8309	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMED_8311	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMED_8312	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMED_8317	COG0315	cyclic pyranopterin monophosphate synthase activity
AMED_8317	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMED_8321	COG5002	protein histidine kinase activity
AMED_8322	COG0745	RESPONSE REGULATOR receiver
AMED_8326	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMED_8331	COG1349	DNA-binding transcription factor activity
AMED_8334	COG2860	membrane
AMED_8335	COG2197	response regulator
AMED_8338	COG0477	Major facilitator Superfamily
AMED_8340	COG0667	Aldo Keto reductase
AMED_8341	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMED_8344	COG0515	serine threonine protein kinase
AMED_8344	COG2815	serine threonine protein kinase
AMED_8345	COG0483	inositol monophosphate 1-phosphatase activity
AMED_8347	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMED_8350	COG0297	glycogen (starch) synthase activity
AMED_8354	COG3285	dna ligase
AMED_8354	COG1793	dna ligase
AMED_8356	COG0583	DNA-binding transcription factor activity
AMED_8358	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMED_8358	COG2755	lipolytic protein G-D-S-L family
AMED_8370	COG0444	Belongs to the ABC transporter superfamily
AMED_8371	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMED_8372	COG0601	transmembrane transport
AMED_8374	COG0747	negative chemotaxis
AMED_8380	COG3469	chitinase activity
AMED_8383	COG4336	lyase activity
AMED_8384	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMED_8385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMED_8386	COG1984	allophanate hydrolase subunit 2
AMED_8394	COG1321	iron dependent repressor
AMED_8398	COG1024	Enoyl-CoA hydratase
AMED_8399	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_8404	COG1169	isochorismate synthase
AMED_8407	COG2182	Extracellular solute-binding protein
AMED_8408	COG1175	transmembrane transport
AMED_8409	COG0395	ABC-type sugar transport system, permease component
AMED_8414	COG1595	DNA-templated transcription, initiation
AMED_8417	COG0277	FAD linked oxidase domain protein
AMED_8422	COG4152	abc transporter atp-binding protein
AMED_8425	COG0415	Belongs to the DNA photolyase family
AMED_8429	COG1960	acyl-CoA dehydrogenase activity
AMED_8434	COG2017	converts alpha-aldose to the beta-anomer
AMED_8436	COG1309	transcriptional regulator
AMED_8441	COG0259	pyridoxamine-phosphate oxidase activity
AMED_8445	COG0829	nickel cation binding
AMED_8446	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AMED_8448	COG0804	urea catabolic process
AMED_8449	COG0832	Belongs to the urease beta subunit family
AMED_8450	COG0831	urea catabolic process
AMED_8457	COG2197	response regulator
AMED_8458	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMED_8461	COG5650	phosphatidylinositol metabolic process
AMED_8462	COG1228	amidohydrolase
AMED_8463	COG0577	efflux transmembrane transporter activity
AMED_8463	COG1136	(ABC) transporter
AMED_8464	COG0577	efflux transmembrane transporter activity
AMED_8464	COG1136	(ABC) transporter
AMED_8467	COG0745	RESPONSE REGULATOR receiver
AMED_8468	COG2205	protein histidine kinase activity
AMED_8473	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMED_8478	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AMED_8479	COG2814	Major facilitator Superfamily
AMED_8482	COG2252	PERMEase
AMED_8487	COG2814	Major facilitator Superfamily
AMED_8489	COG1278	Cold shock
AMED_8493	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMED_8494	COG0318	PFAM AMP-dependent synthetase and ligase
AMED_8496	COG1595	DNA-templated transcription, initiation
AMED_8498	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMED_8506	COG0384	phenazine biosynthesis protein PhzF
AMED_8507	COG3304	Inner membrane component domain
AMED_8508	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMED_8515	COG1846	Transcriptional regulator
AMED_8516	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMED_8518	COG1388	LysM domain
AMED_8528	COG2018	Roadblock/LC7 domain
AMED_8531	COG2018	Roadblock/LC7 domain
AMED_8532	COG0642	Histidine kinase
AMED_8533	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMED_8534	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMED_8535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMED_8536	COG1116	anion transmembrane transporter activity
AMED_8543	COG3142	Participates in the control of copper homeostasis
AMED_8547	COG1061	Type III restriction enzyme res subunit
AMED_8551	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_8554	COG0459	protein refolding
AMED_8556	COG1278	Cold shock
AMED_8562	COG2261	transglycosylase associated protein
AMED_8563	COG0688	phosphatidylethanolamine metabolic process
AMED_8565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMED_8568	COG0242	peptide deformylase activity
AMED_8570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMED_8571	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMED_8572	COG0351	phosphomethylpyrimidine kinase
AMED_8576	COG2022	thiamine diphosphate biosynthetic process
AMED_8579	COG0352	thiamine-phosphate diphosphorylase activity
AMED_8581	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMED_8582	COG0477	Major facilitator Superfamily
AMED_8584	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMED_8585	COG2971	BadF BadG BcrA BcrD
AMED_8587	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMED_8593	COG3629	intracellular signal transduction
AMED_8593	COG3903	Transcriptional regulator
AMED_8594	COG5285	phytanoyl-CoA dioxygenase
AMED_8595	COG1917	Cupin 2, conserved barrel domain protein
AMED_8598	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMED_8600	COG1733	regulation of RNA biosynthetic process
AMED_8601	COG4399	Belongs to the UPF0754 family
AMED_8604	COG5416	Lipopolysaccharide assembly protein A domain
AMED_8616	COG1733	regulation of RNA biosynthetic process
AMED_8624	COG0346	lactoylglutathione lyase activity
AMED_8626	COG1832	CoA-binding protein
AMED_8635	COG0745	RESPONSE REGULATOR receiver
AMED_8636	COG2205	protein histidine kinase activity
AMED_8637	COG1492	cobalamin metabolic process
AMED_8638	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMED_8640	COG1309	transcriptional regulator
AMED_8642	COG1620	l-lactate permease
AMED_8644	COG4941	Belongs to the sigma-70 factor family
AMED_8645	COG3795	YCII-related domain
AMED_8646	COG3795	YCII-related domain
AMED_8649	COG2205	protein histidine kinase activity
AMED_8657	COG1595	DNA-templated transcription, initiation
AMED_8665	COG0789	Transcriptional regulator
AMED_8669	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AMED_8676	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMED_8678	COG1329	Transcriptional regulator
AMED_8679	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMED_8680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMED_8684	COG0215	cysteine-tRNA ligase activity
AMED_8692	COG0235	Class ii aldolase
AMED_8695	COG4399	Belongs to the UPF0754 family
AMED_8696	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMED_8697	COG1121	(ABC) transporter
AMED_8698	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMED_8699	COG1609	Transcriptional regulator
AMED_8706	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMED_8708	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMED_8723	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AMED_8726	COG1396	sequence-specific DNA binding
AMED_8734	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMED_8736	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMED_8737	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMED_8738	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMED_8743	COG0789	Transcriptional regulator
AMED_8746	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMED_8748	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMED_8754	COG0037	tRNA processing
AMED_8757	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMED_8759	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMED_8760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMED_8777	COG2188	Transcriptional regulator
AMED_8780	COG1674	ftsk spoiiie
AMED_8787	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMED_8788	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMED_8794	COG1754	DNA topoisomerase type I activity
AMED_8794	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMED_8798	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMED_8799	COG1111	helicase
AMED_8799	COG1205	dead DEAH box helicase
AMED_8808	COG1472	Belongs to the glycosyl hydrolase 3 family
AMED_8809	COG3876	Protein conserved in bacteria
AMED_8810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMED_8811	COG1737	Transcriptional regulator
AMED_8812	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AMED_8813	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMED_8815	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AMED_8817	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMED_8821	COG3104	oligopeptide transport
AMED_8822	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AMED_8824	COG0596	Alpha beta hydrolase
AMED_8841	COG2272	Belongs to the type-B carboxylesterase lipase family
AMED_8843	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMED_8851	COG2894	cell division
AMED_8853	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMED_8855	COG1408	metallophosphoesterase
AMED_8856	COG2226	methyltransferase
AMED_8863	COG0463	Glycosyl transferase, family 2
AMED_8864	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AMED_8866	COG2192	nodulation
AMED_8869	COG0076	glutamate decarboxylase activity
AMED_8870	COG0783	Belongs to the Dps family
AMED_8871	COG1764	response to oxidative stress
AMED_8876	COG2814	Major facilitator Superfamily
AMED_8879	COG1690	Belongs to the RtcB family
AMED_8886	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMED_8892	COG0583	DNA-binding transcription factor activity
AMED_8893	COG0697	spore germination
AMED_8896	COG3795	YCII-related domain
AMED_8897	COG4941	Belongs to the sigma-70 factor family
AMED_8898	COG4608	Belongs to the ABC transporter superfamily
AMED_8902	COG0747	negative chemotaxis
AMED_8904	COG1216	Glycosyl transferase, family 2
AMED_8908	COG1215	transferase activity, transferring glycosyl groups
AMED_8910	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMED_8911	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMED_8912	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMED_8914	COG1733	regulation of RNA biosynthetic process
AMED_8915	COG3467	pyridoxamine 5'-phosphate
AMED_8916	COG2801	Transposase and inactivated derivatives
AMED_8925	COG1116	anion transmembrane transporter activity
AMED_8926	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMED_8928	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMED_8929	COG2205	protein histidine kinase activity
AMED_8930	COG0745	RESPONSE REGULATOR receiver
AMED_8933	COG2197	response regulator
AMED_8937	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMED_8938	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMED_8938	COG5479	isomerase activity
AMED_8946	COG1674	ftsk spoiiie
AMED_8954	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
AMED_8955	COG2175	clavaminate synthase activity
AMED_8966	COG4702	Belongs to the UPF0303 family
AMED_8968	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMED_8969	COG0789	Transcriptional regulator
AMED_8970	COG0395	ABC-type sugar transport system, permease component
AMED_8971	COG1175	transmembrane transport
AMED_8974	COG1802	Transcriptional regulator
AMED_8980	COG3973	AAA domain
AMED_8986	COG0673	inositol 2-dehydrogenase activity
AMED_8989	COG3345	alpha-galactosidase
AMED_8992	COG2188	Transcriptional regulator
AMED_8993	COG1397	ADP-ribosylglycohydrolase
AMED_8994	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMED_8997	COG0596	Alpha beta hydrolase
AMED_8998	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AMED_8999	COG3706	GGDEF domain
AMED_8999	COG0745	RESPONSE REGULATOR receiver
AMED_9001	COG1316	TRANSCRIPTIONal
AMED_9003	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMED_9004	COG0581	inorganic phosphate transmembrane transporter activity
AMED_9006	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMED_9008	COG0745	RESPONSE REGULATOR receiver
AMED_9015	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AMED_9016	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMED_9017	COG1984	allophanate hydrolase subunit 2
AMED_9027	COG3845	ABC transporter
AMED_9034	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMED_9047	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMED_9049	COG1132	(ABC) transporter
AMED_9050	COG0047	phosphoribosylformylglycinamidine synthase activity
AMED_9051	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMED_9060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMED_9062	COG1126	abc transporter atp-binding protein
AMED_9063	COG0765	amino acid transport
AMED_9065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMED_9067	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMED_9068	COG4948	Mandelate Racemase Muconate Lactonizing
AMED_9071	COG2186	Transcriptional regulator
AMED_9076	COG0546	phosphoglycolate phosphatase activity
AMED_9079	COG0436	Aminotransferase
AMED_9080	COG5280	Phage tail tape measure protein TP901
AMED_9080	COG3953	SLT domain
AMED_9087	COG0584	glycerophosphoryl diester phosphodiesterase
AMED_9092	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMED_9094	COG2814	Major facilitator Superfamily
AMED_9095	COG0025	NhaP-type Na H and K H
AMED_9096	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMED_9098	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMED_9105	COG0745	RESPONSE REGULATOR receiver
AMED_9105	COG3706	GGDEF domain
AMED_9112	COG0667	Aldo Keto reductase
AMED_9113	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_9122	COG0586	Pfam SNARE associated Golgi protein
AMED_9125	COG0277	FAD linked oxidase domain protein
AMED_9126	COG3467	pyridoxamine 5'-phosphate
AMED_9130	COG0586	Pfam SNARE associated Golgi protein
AMED_9133	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_9134	COG0572	uridine kinase
AMED_9135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMED_9142	COG0243	molybdopterin cofactor binding
AMED_9151	COG1136	(ABC) transporter
AMED_9152	COG4221	oxidoreductase activity
AMED_9155	COG0542	response to heat
AMED_9160	COG0412	Dienelactone hydrolase
AMED_9163	COG0789	Transcriptional regulator
AMED_9164	COG0484	heat shock protein binding
AMED_9165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMED_9166	COG0443	Heat shock 70 kDa protein
AMED_9173	COG0247	lactate metabolic process
AMED_9173	COG2181	nitrate reductase activity
AMED_9176	COG2340	Cysteine-rich secretory protein family
AMED_9183	COG4941	Belongs to the sigma-70 factor family
AMED_9184	COG3795	YCII-related domain
AMED_9185	COG2124	cytochrome p450
AMED_9194	COG3663	DNA glycosylase
AMED_9195	COG2197	response regulator
AMED_9196	COG1960	acyl-CoA dehydrogenase activity
AMED_9198	COG0477	Major facilitator Superfamily
AMED_9202	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMED_9207	COG1126	abc transporter atp-binding protein
AMED_9212	COG1305	Transglutaminase-like
AMED_9215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMED_9217	COG0022	dehydrogenase e1 component
AMED_9218	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMED_9223	COG3030	protein affecting phage T7 exclusion by the F plasmid
AMED_9231	COG1309	transcriptional regulator
AMED_9232	COG2030	dehydratase
AMED_9233	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_9234	COG0183	Belongs to the thiolase family
AMED_9250	COG1131	(ABC) transporter
AMED_9253	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AMED_9256	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMED_9259	COG4585	Histidine kinase
AMED_9260	COG2197	response regulator
AMED_9261	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_9265	COG1131	(ABC) transporter
AMED_9268	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMED_9270	COG1136	(ABC) transporter
AMED_9272	COG2197	response regulator
AMED_9275	COG0402	S-adenosylhomocysteine deaminase activity
AMED_9276	COG4221	oxidoreductase activity
AMED_9279	COG2814	Major facilitator Superfamily
AMED_9280	COG1846	Transcriptional regulator
AMED_9281	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMED_9283	COG1595	DNA-templated transcription, initiation
AMED_9285	COG1695	Transcriptional regulator
AMED_9287	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMED_9288	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMED_9289	COG0673	inositol 2-dehydrogenase activity
AMED_9290	COG1940	carbohydrate kinase activity
AMED_9296	COG0360	Binds together with S18 to 16S ribosomal RNA
AMED_9298	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMED_9299	COG0359	binds to the 23S rRNA
AMED_9307	COG3384	dioxygenase
AMED_9312	COG2197	response regulator
AMED_9315	COG0477	Major facilitator Superfamily
AMED_9316	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMED_9318	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMED_9329	COG1028	Short-chain dehydrogenase reductase Sdr
AMED_9330	COG0495	leucyl-tRNA aminoacylation
AMED_9333	COG1678	Uncharacterized ACR, COG1678
AMED_9346	COG0617	tRNA 3'-terminal CCA addition
AMED_9354	COG3118	belongs to the thioredoxin family
AMED_9354	COG0492	ferredoxin-NADP+ reductase activity
AMED_9355	COG3409	Peptidoglycan-binding domain 1 protein
AMED_9355	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMED_9358	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMED_9360	COG1192	Involved in chromosome partitioning
AMED_9361	COG0357	Ribosomal RNA small subunit methyltransferase G
AMED_9364	COG0706	membrane insertase activity
AMED_9365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane