locus-tag class description AMETH_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AMETH_0002 ENOG4105JQN Transcriptional regulator AMETH_0005 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AMETH_0006 ENOG4108J5G 6-phosphogluconate dehydrogenase AMETH_0007 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AMETH_0008 ENOG4105K7N UPF0232 protein AMETH_0009 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AMETH_0010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AMETH_0014 ENOG4107ZVI PhiRv2 prophage protein AMETH_0030 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AMETH_0033 ENOG4108YYC ycei family AMETH_0048 ENOG4107ZXI Rhomboid family AMETH_0051 ENOG4108U4N (sortase) family AMETH_0055 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AMETH_0056 ENOG4105CIG ABC transporter AMETH_0059 ENOG4107TPY serine threonine protein kinase AMETH_0060 ENOG4105CJN penicillin-binding protein AMETH_0063 ENOG4105HZM Fha domain containing protein AMETH_0064 ENOG4105TV9 FHA Domain-Containing protein AMETH_0069 ENOG4105C7B Threonine dehydratase AMETH_0078 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AMETH_0079 ENOG41073TP transcriptional regulator AMETH_0080 ENOG4105DEF Extracellular solute-binding protein, family 5 AMETH_0082 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AMETH_0084 ENOG4108JQ7 (ABC) transporter AMETH_0086 ENOG4105CHR reductase AMETH_0087 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AMETH_0090 ENOG4105CI0 Citrate lyase AMETH_0107 ENOG4108T5E Copper resistance protein AMETH_0110 ENOG4105E90 ABC transporter AMETH_0111 ENOG4108IJ8 ABC transporter AMETH_0112 ENOG4105E90 ABC transporter AMETH_0113 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AMETH_0119 ENOG4105C6Y Udp-glucose 6-dehydrogenase AMETH_0124 ENOG4105BZU Histidine kinase AMETH_0125 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_0128 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AMETH_0129 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AMETH_0137 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AMETH_0138 ENOG4105CPP Dehydrogenase, E1 component AMETH_0140 ENOG4105CP9 extracellular ligand-binding receptor AMETH_0141 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AMETH_0142 ENOG4105C32 Amino acid ABC transporter (Permease) AMETH_0143 ENOG4108IQE Amp-dependent synthetase and ligase AMETH_0144 ENOG4105C0Z ABC transporter AMETH_0145 ENOG4108IV0 ABC, transporter AMETH_0146 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AMETH_0148 ENOG4108HW3 (ABC) transporter AMETH_0149 ENOG4105E5Q amino acid AbC transporter AMETH_0155 ENOG4108HRK Histidine kinase AMETH_0159 ENOG4107QN1 sodium solute AMETH_0161 ENOG4107QN1 sodium solute AMETH_0162 ENOG4105VFE sira family AMETH_0167 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AMETH_0170 ENOG4105CEU Arginine dihydrolase AMETH_0178 ENOG4105MSY salicylate hydroxylase AMETH_0179 ENOG41067SE Tetr family transcriptional regulator AMETH_0182 ENOG4105C4M (Ubiquinol oxidase) subunit I AMETH_0183 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AMETH_0184 ENOG4108JJ9 ABC, transporter AMETH_0187 ENOG41067TZ transcriptional regulator, MarR family AMETH_0188 ENOG4105ME7 Membrane AMETH_0191 ENOG4105EBR Carboxylesterase AMETH_0192 ENOG4105CB5 ATP-dependent DNA helicase recG AMETH_0201 ENOG4105CS9 pantothenic acid kinase AMETH_0202 ENOG4108UVJ appr-1-p processing domain protein AMETH_0204 ENOG4105GCF PGAM AMETH_0212 ENOG4106032 Glutathionylspermidine synthase AMETH_0213 ENOG4105P3N Membrane AMETH_0214 ENOG4108J2P Alpha beta hydrolase fold AMETH_0216 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AMETH_0219 ENOG4105D5U fad dependent oxidoreductase AMETH_0223 ENOG4108T5E Copper resistance protein AMETH_0233 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AMETH_0234 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_0236 ENOG4108KP7 hydrolase AMETH_0237 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_0240 ENOG4106YN8 Prenyltransferase AMETH_0241 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases AMETH_0245 ENOG410602S Transferase AMETH_0247 ENOG4105IQ5 FAD linked oxidase domain protein AMETH_0248 ENOG4108RG3 short-chain dehydrogenase reductase AMETH_0250 ENOG4108MKI Glycosyl transferase, family 2 AMETH_0254 ENOG4108VC7 Protein of unknown function (DUF2587) AMETH_0256 ENOG4105CPQ Dehydrogenase AMETH_0257 ENOG4105IIU Aminopeptidase AMETH_0261 ENOG4108X79 transcriptional regulator AMETH_0273 ENOG4105BZU Histidine kinase AMETH_0274 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_0276 ENOG4105KF0 sporulation and cell division protein, SsgA AMETH_0281 ENOG4105FDF Could be involved in DNA repair (By similarity) AMETH_0287 ENOG4105CIH Imidazole acetol-phosphate transaminase AMETH_0289 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_0290 ENOG4105CRK lysyL-tRNA synthetase AMETH_0297 ENOG4106A3M Cytochrome p-450 AMETH_0300 ENOG4105E1F short-chain dehydrogenase reductase AMETH_0302 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_0306 ENOG4108SUT Major Facilitator Superfamily AMETH_0308 ENOG4105VPX protein, conserved in bacteria AMETH_0309 ENOG4105D9G High-affinity AMETH_0312 ENOG4105H3G oxidoreductase AMETH_0315 ENOG4107R33 ppx gppa phosphatase AMETH_0316 ENOG4107R33 ppx gppa phosphatase AMETH_0319 ENOG4105CS2 ec 3.2.1.21 AMETH_0327 ENOG4105DQ5 transport system permease protein AMETH_0328 ENOG4105TVJ transport system, permease AMETH_0329 ENOG4105E0A ABC, transporter AMETH_0331 ENOG4105DIM ABC transporter AMETH_0332 ENOG4105CIG ABC transporter AMETH_0345 ENOG4105EVN Prephenate dehydrogenase AMETH_0346 ENOG4105CH2 amidohydrolase AMETH_0348 ENOG4108Z6B deaminase AMETH_0355 ENOG4105EC2 ftsk spoIIIe AMETH_0360 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold AMETH_0364 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AMETH_0368 ENOG4107XTP (EAL) domain protein AMETH_0369 ENOG4105C0F tryptophanase EC 4.1.99.1 AMETH_0370 ENOG4105C0F tryptophanase EC 4.1.99.1 AMETH_0372 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AMETH_0381 ENOG4105CHR reductase AMETH_0389 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AMETH_0393 ENOG4106BRA Membrane AMETH_0397 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AMETH_0400 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AMETH_0401 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AMETH_0403 ENOG4105V9F hemagglutinin AMETH_0404 ENOG4105TT9 Protein of unknown function (DUF2516) AMETH_0406 ENOG4105E90 ABC transporter AMETH_0407 ENOG4105R40 Glycine betaine carnitine choline AMETH_0410 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AMETH_0411 ENOG4105CIY formyltetrahydrofolate deformylase AMETH_0414 ENOG4108Z20 Acyl-transferase AMETH_0418 ENOG4107R4N Cell wall formation (By similarity) AMETH_0421 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AMETH_0423 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AMETH_0425 ENOG4105W1N transcriptional regulator AMETH_0427 ENOG4107S5I aldo keto reductase AMETH_0428 ENOG4105BZU Histidine kinase AMETH_0431 ENOG41063NU Membrane AMETH_0432 ENOG4105EY0 Xylose isomerase domain protein TIM barrel AMETH_0433 ENOG41062BK proline dehydrogenase AMETH_0435 ENOG4105II7 pyrroline-5-carboxylate reductase AMETH_0441 ENOG4108RXW HAD-superfamily subfamily IB hydrolase AMETH_0445 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_0447 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AMETH_0448 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AMETH_0449 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AMETH_0450 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AMETH_0451 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AMETH_0456 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AMETH_0457 ENOG4108RH7 phosphoglycerate mutase AMETH_0461 ENOG4105CRE cytochrome C AMETH_0471 ENOG4107SIQ Naphthoate synthase AMETH_0472 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AMETH_0477 ENOG4105ECY inositol monophosphatase AMETH_0479 ENOG4108MJN Glycosyl Transferase AMETH_0480 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_0484 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AMETH_0485 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AMETH_0486 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AMETH_0489 ENOG4108IEH NADH dehydrogenase subunit g AMETH_0490 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AMETH_0491 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AMETH_0492 ENOG41087XN oxidoreductase AMETH_0493 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AMETH_0496 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AMETH_0499 ENOG4105EAH synthase AMETH_0501 ENOG4105DQU oxidoreductase, subunit beta AMETH_0502 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AMETH_0504 ENOG4108VVK transcriptional Regulator, AsnC AMETH_0505 ENOG4105CIK Amidinotransferase AMETH_0507 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AMETH_0510 ENOG4105EQQ protein containing aminopeptidase domain AMETH_0512 ENOG4105K64 Glycosyl transferase, family 2 AMETH_0514 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AMETH_0515 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AMETH_0532 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AMETH_0533 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AMETH_0537 ENOG4107RRD Dehydrogenase AMETH_0538 ENOG4105CAQ asparagine synthetase AMETH_0542 ENOG4105C6Y Udp-glucose 6-dehydrogenase AMETH_0543 ENOG4105DYW oxidoreductase AMETH_0545 ENOG4105D0M Protease HtpX homolog AMETH_0546 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AMETH_0547 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) AMETH_0548 ENOG4108IG5 Transcriptional regulator AMETH_0549 ENOG4107ZXU DSBA oxidoreductase AMETH_0554 ENOG4108VPT UPF0234 protein AMETH_0557 ENOG4107ZVI PhiRv2 prophage protein AMETH_0558 ENOG4105KRM Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AMETH_0563 ENOG4105CNU cell division protein FtsK AMETH_0578 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AMETH_0584 ENOG4105FF5 Membrane AMETH_0585 ENOG4107RBB ABC transporter, permease AMETH_0587 ENOG4105CHP RNA polymerase AMETH_0594 ENOG4105TVJ transport system, permease AMETH_0595 ENOG4105DQ5 transport system permease protein AMETH_0596 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AMETH_0597 ENOG4105E8G Major facilitator Superfamily AMETH_0601 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_0603 ENOG4108HUF Transporter AMETH_0605 ENOG4105E2K Glycosyl transferase (Group 1 AMETH_0608 ENOG4107STQ Multicopper oxidase AMETH_0609 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_0612 ENOG4105BZU Histidine kinase AMETH_0613 ENOG4107T5V SNARE associated Golgi AMETH_0614 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AMETH_0616 ENOG4105WDJ 50S ribosomal protein L33 AMETH_0617 ENOG410900P UPF0336 protein AMETH_0621 ENOG4108VQR secreted hydrolase AMETH_0625 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AMETH_0626 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AMETH_0628 ENOG4108VZM 50s ribosomal protein L10 AMETH_0642 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AMETH_0647 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AMETH_0648 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AMETH_0649 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AMETH_0652 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AMETH_0653 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AMETH_0654 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AMETH_0655 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AMETH_0656 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AMETH_0657 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AMETH_0658 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AMETH_0659 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AMETH_0660 ENOG41082SA 50s ribosomal protein l29 AMETH_0661 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AMETH_0662 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AMETH_0663 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AMETH_0664 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AMETH_0665 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AMETH_0666 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AMETH_0667 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AMETH_0669 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AMETH_0670 ENOG410849U 50S ribosomal protein L30 AMETH_0671 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AMETH_0675 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AMETH_0677 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AMETH_0678 ENOG41067V7 50S ribosomal protein L36 AMETH_0679 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AMETH_0681 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AMETH_0682 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AMETH_0683 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AMETH_0684 ENOG4108ZT0 50S ribosomal protein l17 AMETH_0685 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AMETH_0692 ENOG4105EC2 ftsk spoIIIe AMETH_0693 ENOG4105CFG Acts as a chaperone (By similarity) AMETH_0698 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AMETH_0700 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AMETH_0705 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AMETH_0710 ENOG4105CPQ Dehydrogenase AMETH_0711 ENOG4105E98 transcriptional regulator DeoR family AMETH_0713 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AMETH_0714 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 AMETH_0715 ENOG4108097 ATP-binding protein AMETH_0717 ENOG4105D8K carboxyl transferase AMETH_0718 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_0720 ENOG41073TP transcriptional regulator AMETH_0722 ENOG41080E2 ribosomal-protein-alanine acetyltransferase AMETH_0723 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AMETH_0725 ENOG4105KVH Transcriptional regulator AMETH_0727 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AMETH_0728 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AMETH_0729 ENOG4105F6U Short-chain dehydrogenase reductase Sdr AMETH_0730 ENOG4108IND Tetr family transcriptional regulator AMETH_0731 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AMETH_0737 ENOG4108VT4 AMETH_0739 ENOG4107QVP Dehydrogenase AMETH_0748 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AMETH_0754 ENOG4107RSM transcriptional regulator AMETH_0764 ENOG4105DR5 peptidase AMETH_0766 ENOG4105CMV Succinyl-CoA synthetase subunit beta AMETH_0771 ENOG4105DC1 bifunctional purine biosynthesis protein purh AMETH_0772 ENOG4105JAB phenazine biosynthesis protein, phzf family AMETH_0777 ENOG4105C0B DNA polymerase III (alpha subunit) AMETH_0778 ENOG4105E09 nadh pyrophosphatase AMETH_0783 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AMETH_0785 ENOG4105F27 Major Facilitator AMETH_0797 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AMETH_0798 ENOG4105CGK Exodeoxyribonuclease III AMETH_0804 ENOG4105C31 Tryptophanyl-tRNA synthetase AMETH_0805 ENOG4107H3J ribonuclease AMETH_0813 ENOG4105DIH basic membrane AMETH_0814 ENOG4108JQ9 ABC transporter AMETH_0820 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AMETH_0821 ENOG4105E5T Major Facilitator Superfamily AMETH_0829 ENOG4105CPQ Dehydrogenase AMETH_0834 ENOG4106YKD Cytochrome p-450 AMETH_0837 ENOG4105C26 Dehydrogenase AMETH_0838 ENOG4105C26 Dehydrogenase AMETH_0839 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AMETH_0841 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AMETH_0845 ENOG4105CPC Aldo Keto reductase AMETH_0848 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain AMETH_0850 ENOG4107TPY serine threonine protein kinase AMETH_0855 ENOG4107RM1 amidohydrolase AMETH_0861 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AMETH_0862 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AMETH_0863 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AMETH_0868 ENOG4108JIK carboxylase AMETH_0870 ENOG4107QJT sodium dicarboxylate symporter AMETH_0871 ENOG4107WR6 Maf-like protein AMETH_0875 ENOG4107XBN GntR Family Transcriptional Regulator AMETH_0878 ENOG4105D8K carboxyl transferase AMETH_0881 ENOG41082YX Transcriptional regulator, arsr family AMETH_0882 ENOG410905P Pyridoxamine 5-phosphate AMETH_0886 ENOG4107YPT transcriptional regulator AMETH_0888 ENOG4105K4H Nlp p60 protein AMETH_0897 ENOG4107TK4 histidinol-phosphate phosphatase AMETH_0898 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AMETH_0899 ENOG41065SU Two-component system sensor kinase AMETH_0909 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_0914 ENOG4107TB5 TRANSCRIPTIONal AMETH_0915 ENOG4107TB5 TRANSCRIPTIONal AMETH_0919 ENOG4107GJV short-chain dehydrogenase reductase AMETH_0920 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AMETH_0921 ENOG4107RGC Glycosyl transferase, family 2 AMETH_0923 ENOG4105E2K Glycosyl transferase (Group 1 AMETH_0929 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AMETH_0932 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase AMETH_0934 ENOG4108Z4U Ferredoxin AMETH_0941 ENOG4107R4C succinyl-diaminopimelate desuccinylase AMETH_0943 ENOG4108URH decarboxylase AMETH_0945 ENOG4105C3Q Glycosyl transferase, family 2 AMETH_0948 ENOG4108R3E Dna-3-methyladenine glycosylase i AMETH_0949 ENOG4108UKI Enoyl-CoA hydratase AMETH_0951 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AMETH_0952 ENOG4107RSM transcriptional regulator AMETH_0955 ENOG4108DMH HTH_ARAC AMETH_0956 ENOG4107ZBN O-methyltransferase AMETH_0958 ENOG4106684 AMETH_0959 ENOG4105C0H protease AMETH_0960 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AMETH_0963 ENOG4105CJW magnesium transporter AMETH_0966 ENOG4105C1G acyl-Coa dehydrogenase AMETH_0980 ENOG4105D7N magnesium and cobalt transport protein CorA AMETH_0983 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_0987 ENOG4105DB7 PHP domain protein AMETH_0988 ENOG41081FY multiple antibiotic resistance (MarC)-related AMETH_0993 ENOG4108V0P LemA family AMETH_0994 ENOG4105D0M Protease HtpX homolog AMETH_0997 ENOG4105C1J atp-dependent rna helicase AMETH_1003 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AMETH_1005 ENOG4106HB6 Alpha beta hydrolase AMETH_1009 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AMETH_1010 ENOG4108IFG nitrite reductase, (NAD(P)H) AMETH_1011 ENOG4107QND Nitrite extrusion protein AMETH_1012 ENOG4107QZF nitrite reductase NADPH large subunit AMETH_1013 ENOG4105WZK nitrite reductase NADPH small subunit AMETH_1016 ENOG4105CHR reductase AMETH_1021 ENOG4105D29 Helix-turn-helix type 11 domain protein AMETH_1025 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AMETH_1027 ENOG4107SVH Potassium channel protein AMETH_1032 ENOG4108WQ6 secreted protein AMETH_1033 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AMETH_1040 ENOG4108JGH Tetr family transcriptional regulator AMETH_1043 ENOG4105C1V Peptidase, M16 AMETH_1048 ENOG4105C6Z Gluconate AMETH_1049 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AMETH_1051 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AMETH_1055 ENOG4105EGD dinuclear metal center protein, YbgI family AMETH_1057 ENOG4105CVJ phosphoglycerate mutase AMETH_1058 ENOG4105CF7 AraC family transcriptional regulator AMETH_1059 ENOG4105CPC Aldo Keto reductase AMETH_1063 ENOG4105FBW Monooxygenase AMETH_1077 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AMETH_1080 ENOG4105C26 Dehydrogenase AMETH_1081 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AMETH_1082 ENOG4107TYH extracellular solute-binding protein family 1 AMETH_1083 ENOG4105D81 ABC transporter, permease AMETH_1084 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component AMETH_1085 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AMETH_1086 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AMETH_1092 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AMETH_1096 ENOG4105ECQ AraC Family Transcriptional Regulator AMETH_1098 ENOG4105C5F glutamine synthetase AMETH_1100 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AMETH_1102 ENOG4105D2X ABC transporter substrate-binding protein AMETH_1103 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AMETH_1108 ENOG4108HR6 Dehydrogenase AMETH_1109 ENOG4108UTP (2Fe-2S)-binding domain protein AMETH_1110 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AMETH_1111 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AMETH_1114 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AMETH_1118 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AMETH_1122 ENOG4105C5F glutamine synthetase AMETH_1127 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AMETH_1131 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AMETH_1135 ENOG41063PX domain protein AMETH_1137 ENOG4105DJZ UPF0182 protein AMETH_1139 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AMETH_1140 ENOG4105CAK Cell division ATP-binding protein ftsE AMETH_1141 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) AMETH_1142 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AMETH_1148 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_1152 ENOG4105C84 Histidine ammonia-lyase AMETH_1153 ENOG4105CGP Urocanate hydratase AMETH_1156 ENOG4105CI2 imidazolone-5-propionate hydrolase AMETH_1163 ENOG4105BZU Histidine kinase AMETH_1164 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AMETH_1166 ENOG4105CJ1 ABC, transporter AMETH_1168 ENOG4105CQ7 ATP-dependent helicase AMETH_1171 ENOG4105C1G acyl-Coa dehydrogenase AMETH_1174 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_1177 ENOG4105CHU acetyl-coa acetyltransferase AMETH_1179 ENOG4108RZE Tetr family transcriptional regulator AMETH_1181 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) AMETH_1184 ENOG41090TK Short-chain dehydrogenase reductase Sdr AMETH_1185 ENOG4105J4Q Transcriptional regulator AMETH_1187 ENOG4105CAY ferredoxin--nadp reductase AMETH_1188 ENOG4105C1G acyl-Coa dehydrogenase AMETH_1193 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_1195 ENOG4105C1G acyl-Coa dehydrogenase AMETH_1197 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_1198 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) AMETH_1199 ENOG4105FUY alpha subunit AMETH_1200 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit AMETH_1201 ENOG4106A3M Cytochrome p-450 AMETH_1208 ENOG4105CY3 ABC transporter, permease AMETH_1209 ENOG4105DHJ ABC, transporter AMETH_1217 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AMETH_1220 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AMETH_1235 ENOG4106YT9 Enoyl-CoA hydratase AMETH_1239 ENOG4108KPJ rna polymerase sigma factor AMETH_1241 ENOG4105BZU Histidine kinase AMETH_1242 ENOG4105WN5 stage II sporulation protein AMETH_1243 ENOG4106NZI LysR family Transcriptional regulator AMETH_1244 ENOG4105D82 Glutamate dehydrogenase AMETH_1246 ENOG4105DKW ABC transporter AMETH_1247 ENOG4107RSM transcriptional regulator AMETH_1253 ENOG41080RH Thioredoxin AMETH_1254 ENOG4105DTD Dehydrogenase AMETH_1266 ENOG4105JQZ Methyltransferase AMETH_1267 ENOG4105C34 Pseudouridine synthase AMETH_1270 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AMETH_1271 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AMETH_1273 ENOG4108MJI response regulator AMETH_1274 ENOG4105WN5 stage II sporulation protein AMETH_1275 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_1279 ENOG4105C01 Dihydroxy-acid dehydratase AMETH_1284 ENOG4105CFM UPF0317 protein AMETH_1294 ENOG4105CWX Alpha-1,2-mannosidase AMETH_1301 ENOG4108PGP mmge prpd family protein AMETH_1303 ENOG4105CI0 Citrate lyase AMETH_1304 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_1306 ENOG4105C32 Amino acid ABC transporter (Permease) AMETH_1307 ENOG4108HWW ABC transporter AMETH_1308 ENOG4105C0Z ABC transporter AMETH_1309 ENOG4108IV0 ABC, transporter AMETH_1312 ENOG4107EFR Flavocytochrome c AMETH_1315 ENOG4105DQE DNA ligase AMETH_1318 ENOG4105MC2 DSBA oxidoreductase AMETH_1319 ENOG4105E2A Dehydrogenase AMETH_1326 ENOG4105KXX peptidase s58 dmpa AMETH_1329 ENOG4105ETE Transcriptional regulator (LacI family AMETH_1331 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AMETH_1336 ENOG4105C75 arginyL-tRNA synthetase AMETH_1337 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AMETH_1338 ENOG4105D6E homoserine dehydrogenase AMETH_1339 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AMETH_1340 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AMETH_1343 ENOG4105VFB Binds the 23S rRNA (By similarity) AMETH_1344 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AMETH_1345 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AMETH_1347 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AMETH_1349 ENOG4105ESV Glycosyl transferase, family 4 AMETH_1351 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) AMETH_1352 ENOG4106DE0 ATP synthase AMETH_1353 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AMETH_1354 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AMETH_1355 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AMETH_1356 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AMETH_1357 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AMETH_1358 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AMETH_1363 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AMETH_1365 ENOG4105N14 lysine exporter protein LysE YggA AMETH_1366 ENOG4105RFZ Methylmalonyl-coA mutase AMETH_1371 ENOG4108A04 Beta-lactamase AMETH_1375 ENOG4105GAK amidohydrolase 2 AMETH_1376 ENOG4107HP6 Transcriptional regulator AMETH_1378 ENOG4108IPT Naphthoate synthase AMETH_1381 ENOG4108SC4 )-transporter AMETH_1382 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) AMETH_1387 ENOG4105CMT Dihydroxyacetone kinase AMETH_1390 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AMETH_1393 ENOG41082JN Transcriptional regulator AMETH_1407 ENOG4108RWI nicotinamidase AMETH_1408 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AMETH_1409 ENOG4107RKP Nicotinate phosphoribosyltransferase AMETH_1410 ENOG4108Q7D Domain of unknown function (DUF2017) AMETH_1411 ENOG4105KXX peptidase s58 dmpa AMETH_1419 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AMETH_1420 ENOG4108RQ5 Beta-lactamase domain-containing protein AMETH_1423 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AMETH_1424 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AMETH_1425 ENOG4107R7A Allophanate hydrolase subunit 2 AMETH_1426 ENOG4105P4J Allophanate hydrolase, subunit 1 AMETH_1434 ENOG4108RG3 short-chain dehydrogenase reductase AMETH_1439 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AMETH_1444 ENOG4105EVB acetyltransferase AMETH_1445 ENOG4108YYH Nadph-dependent fmn reductase AMETH_1448 ENOG4107R9S Malate synthase AMETH_1449 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AMETH_1455 ENOG4108KQJ Type 11 methyltransferase AMETH_1459 ENOG4105EPR degv family AMETH_1461 ENOG4105C10 Electron transfer flavoprotein AMETH_1467 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AMETH_1469 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AMETH_1470 ENOG4105BZU Histidine kinase AMETH_1481 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AMETH_1485 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AMETH_1491 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AMETH_1492 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AMETH_1498 ENOG4105MGM doxx family AMETH_1499 ENOG4105C01 Dihydroxy-acid dehydratase AMETH_1501 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AMETH_1507 ENOG4108ZP8 Acetolactate synthase small subunit AMETH_1508 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AMETH_1511 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AMETH_1512 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AMETH_1513 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AMETH_1516 ENOG4105ERH Fumarylacetoacetate hydrolase AMETH_1518 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AMETH_1526 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AMETH_1527 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AMETH_1530 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AMETH_1531 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) AMETH_1533 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AMETH_1540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AMETH_1541 ENOG4105CPF Cell wall formation (By similarity) AMETH_1547 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AMETH_1548 ENOG4105VB9 50S ribosomal protein l28 AMETH_1549 ENOG4105DP4 dak2 domain fusion protein ylov AMETH_1551 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AMETH_1552 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AMETH_1554 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AMETH_1555 ENOG4105DEN Luciferase family AMETH_1557 ENOG4105CT1 (ABC) transporter AMETH_1558 ENOG4105EEM helicase AMETH_1559 ENOG4106H78 methyltransferase AMETH_1560 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AMETH_1564 ENOG41084BZ 50S ribosomal protein L32 AMETH_1565 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AMETH_1566 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AMETH_1567 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AMETH_1570 ENOG4105CAQ asparagine synthetase AMETH_1572 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AMETH_1573 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AMETH_1574 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AMETH_1578 ENOG4108375 Acylphosphatase (EC 3.6.1.7) AMETH_1582 ENOG4107RJ1 sodium solute AMETH_1583 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AMETH_1590 ENOG41069M3 Transcriptional regulator AMETH_1591 ENOG4107R9S Malate synthase AMETH_1597 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AMETH_1598 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AMETH_1601 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) AMETH_1602 ENOG4105C2W permease AMETH_1610 ENOG4105K4P CoA-binding domain protein AMETH_1618 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AMETH_1626 ENOG4105K5M 30s ribosomal protein S16 AMETH_1628 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AMETH_1629 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AMETH_1630 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AMETH_1631 ENOG4107QYR Signal peptidase i AMETH_1632 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AMETH_1634 ENOG41080R2 UPF0102 protein AMETH_1635 ENOG4105C0P Mg chelatase subunit ChlI AMETH_1638 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AMETH_1640 ENOG4105CE9 30S ribosomal protein S2 AMETH_1641 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AMETH_1642 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AMETH_1643 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AMETH_1646 ENOG4107QVI Methyltransferase, type 11 AMETH_1648 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AMETH_1650 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AMETH_1651 ENOG4105DZP Membrane-associated zinc metalloprotease AMETH_1652 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AMETH_1658 ENOG4105JXH GntR family transcriptional regulator AMETH_1659 ENOG4105DJ2 Major Facilitator Superfamily AMETH_1662 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AMETH_1664 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AMETH_1668 ENOG4105C1J atp-dependent rna helicase AMETH_1670 ENOG4107VFR oxidoreductase AMETH_1671 ENOG4107XFJ UPF0246 protein AMETH_1676 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AMETH_1685 ENOG4105C7I Dehydrogenase AMETH_1688 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_1690 ENOG4105D8X mechanosensitive ion channel AMETH_1694 ENOG4109057 AMETH_1696 ENOG4105MC2 DSBA oxidoreductase AMETH_1703 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AMETH_1706 ENOG4105GFG DUF218 domain AMETH_1712 ENOG41073TP transcriptional regulator AMETH_1717 ENOG4105BZU Histidine kinase AMETH_1718 ENOG4105DQE DNA ligase AMETH_1722 ENOG4105C26 Dehydrogenase AMETH_1725 ENOG4105ETE Transcriptional regulator (LacI family AMETH_1726 ENOG4105EDW glycosyl transferase, family 39 AMETH_1727 ENOG4105BZU Histidine kinase AMETH_1731 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AMETH_1732 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AMETH_1733 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AMETH_1734 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AMETH_1735 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AMETH_1739 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AMETH_1747 ENOG4108YYC ycei family AMETH_1748 ENOG4108UYE Lactoylglutathione lyase AMETH_1750 ENOG41080V3 Major Facilitator superfamily AMETH_1753 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AMETH_1757 ENOG4108VQR secreted hydrolase AMETH_1758 ENOG4105FDP GntR family transcriptional regulator AMETH_1759 ENOG4108KD5 ADP-ribosylation crystallin J1 AMETH_1761 ENOG4108RVA ribokinase AMETH_1762 ENOG4105C1G acyl-Coa dehydrogenase AMETH_1763 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AMETH_1766 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AMETH_1770 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AMETH_1771 ENOG4108FUF Transcriptional regulator, IclR family AMETH_1772 ENOG4105CJ1 ABC, transporter AMETH_1775 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AMETH_1776 ENOG4105C03 ribonuclease AMETH_1776 ENOG4105C03 ribonuclease AMETH_1777 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AMETH_1778 ENOG4105K46 50S ribosomal protein l27 AMETH_1779 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AMETH_1780 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AMETH_1781 ENOG4105CSH Transporter AMETH_1783 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AMETH_1784 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AMETH_1787 ENOG4105EPR degv family AMETH_1788 ENOG4105KQC Competence protein AMETH_1789 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AMETH_1790 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AMETH_1792 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AMETH_1801 ENOG4105EA8 2-Nitropropane dioxygenase AMETH_1804 ENOG4108WYP Transcriptional regulator AMETH_1805 ENOG4105C26 Dehydrogenase AMETH_1807 ENOG4105CSH Transporter AMETH_1814 ENOG4105F2Z 3-oxoadipate enol-lactonase AMETH_1816 ENOG41067HS methyltransferase AMETH_1817 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_1820 ENOG4108R85 Short chain dehydrogenase AMETH_1821 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_1828 ENOG4108IG5 Transcriptional regulator AMETH_1829 ENOG4105CPP Dehydrogenase, E1 component AMETH_1830 ENOG4105CPQ Dehydrogenase AMETH_1831 ENOG4105C1G acyl-Coa dehydrogenase AMETH_1834 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta AMETH_1835 ENOG4105BZU Histidine kinase AMETH_1836 ENOG4108Q9V regulatoR AMETH_1840 ENOG4105DHJ ABC, transporter AMETH_1849 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_1850 ENOG4105DP7 Protocatechuate 4,5-dioxygenase AMETH_1856 ENOG4105EFA 4-hydroxyphenylacetate AMETH_1857 ENOG4108JNI Alpha beta hydrolase AMETH_1860 ENOG4105FUY alpha subunit AMETH_1865 ENOG4105BZJ Electron transfer flavoprotein AMETH_1871 ENOG4105CUB amino acid AMETH_1874 ENOG4105CB2 alcohol dehydrogenase AMETH_1877 ENOG41067XF inhibitor AMETH_1880 ENOG4108M7F enoyl-CoA hydratase isomerase AMETH_1885 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AMETH_1886 ENOG4108IY8 ABC, transporter AMETH_1887 ENOG4105GVF (ABC) transporter AMETH_1896 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AMETH_1899 ENOG4105DUM transcriptional regulator, lysR family AMETH_1916 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) AMETH_1918 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AMETH_1921 ENOG4105C8Y Acetylornithine aminotransferase AMETH_1922 ENOG4105C26 Dehydrogenase AMETH_1923 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AMETH_1924 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AMETH_1926 ENOG4105K59 histidine triad (HIT) protein AMETH_1928 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AMETH_1931 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AMETH_1934 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) AMETH_1935 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AMETH_1937 ENOG4108PJD permease AMETH_1943 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AMETH_1945 ENOG4108JCI Transcriptional regulator AMETH_1946 ENOG4108M15 ABC transporter AMETH_1948 ENOG4105BZU Histidine kinase AMETH_1958 ENOG4108KPJ rna polymerase sigma factor AMETH_1959 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AMETH_1961 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AMETH_1962 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AMETH_1974 ENOG4105E2Y ABC, transporter AMETH_1979 ENOG4105TVJ transport system, permease AMETH_1980 ENOG4105DQ5 transport system permease protein AMETH_1988 ENOG4105C0Z ABC transporter AMETH_1989 ENOG4108IV0 ABC, transporter AMETH_1990 ENOG4105C32 Amino acid ABC transporter (Permease) AMETH_1991 ENOG4105C32 Amino acid ABC transporter (Permease) AMETH_1995 ENOG410905P Pyridoxamine 5-phosphate AMETH_1999 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AMETH_2010 ENOG4105CUT histidyl-tRNA synthetase AMETH_2011 ENOG4105CIR epoxide hydrolase AMETH_2012 ENOG4105C7W Xanthine dehydrogenase AMETH_2013 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding AMETH_2014 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AMETH_2015 ENOG4107XBN GntR Family Transcriptional Regulator AMETH_2017 ENOG4108JB8 alcohol dehydrogenase AMETH_2019 ENOG4105CQB FAD linked oxidase domain protein AMETH_2022 ENOG4105C26 Dehydrogenase AMETH_2024 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AMETH_2028 ENOG4105CHU acetyl-coa acetyltransferase AMETH_2029 ENOG4105CC9 acyl-Coa dehydrogenase AMETH_2030 ENOG4105D2B acyl-CoA dehydrogenase AMETH_2031 ENOG4105CGU Enoyl-CoA hydratase AMETH_2032 ENOG4108UKI Enoyl-CoA hydratase AMETH_2034 ENOG4105C1G acyl-Coa dehydrogenase AMETH_2039 ENOG4107RTD sua5 ycio yrdc ywlc family protein AMETH_2042 ENOG4105EMU Dehydrogenase AMETH_2052 ENOG4105CGU Enoyl-CoA hydratase AMETH_2054 ENOG4105CVJ phosphoglycerate mutase AMETH_2062 ENOG4105EUJ GTP cyclohydrolase i AMETH_2065 ENOG4105E39 Enoyl-CoA hydratase AMETH_2068 ENOG4105CKI cobalamin synthesis protein AMETH_2069 ENOG4108MRH transcriptional regulatory protein AMETH_2070 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AMETH_2075 ENOG4108JGH Tetr family transcriptional regulator AMETH_2076 ENOG4107TT5 NLP P60 protein AMETH_2077 ENOG4107R7A Allophanate hydrolase subunit 2 AMETH_2078 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AMETH_2085 ENOG4105EC2 ftsk spoIIIe AMETH_2101 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_2105 ENOG4105YVM Phosphoesterase, PA-phosphatase related AMETH_2112 ENOG4108KPJ rna polymerase sigma factor AMETH_2117 ENOG4108R0M Aminoglycoside AMETH_2119 ENOG4108UMI ABC transporter, permease AMETH_2120 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AMETH_2121 ENOG4105D01 (LipO)protein AMETH_2127 ENOG4107URF beta-phospho-glucomutase AMETH_2130 ENOG4105RE0 Asp Glu hydantoin racemase AMETH_2131 ENOG4106KNT transcriptional regulator AMETH_2132 ENOG4105ETE Transcriptional regulator (LacI family AMETH_2133 ENOG4105C2J ABC transporter AMETH_2134 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AMETH_2135 ENOG4105CNN ABC, transporter AMETH_2141 ENOG4105DET Rhamnulokinase AMETH_2142 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AMETH_2143 ENOG4107QR9 Iron-sulfur cluster binding protein AMETH_2144 ENOG41080R8 Conserved Protein AMETH_2146 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AMETH_2150 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AMETH_2151 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_2156 ENOG4107HP6 Transcriptional regulator AMETH_2160 ENOG4105KV4 Transcriptional regulator AMETH_2161 ENOG4105F27 Major Facilitator AMETH_2167 ENOG4105CSH Transporter AMETH_2170 ENOG410719E cytochrome p450 AMETH_2175 ENOG4108QMY dioxygenase AMETH_2176 ENOG4105DTQ mandelate racemase muconate lactonizing AMETH_2177 ENOG4106NZI LysR family Transcriptional regulator AMETH_2178 ENOG4105FUY alpha subunit AMETH_2181 ENOG4105D2S major facilitator superfamily AMETH_2183 ENOG4105DKK Benzoate AMETH_2185 ENOG4105DQE DNA ligase AMETH_2187 ENOG4105CGD Nad-dependent epimerase dehydratase AMETH_2189 ENOG4107TPY serine threonine protein kinase AMETH_2191 ENOG4105ETE Transcriptional regulator (LacI family AMETH_2194 ENOG4105D9R oxidoreductase AMETH_2196 ENOG4105CSH Transporter AMETH_2197 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AMETH_2206 ENOG4105JSC dimethylmenaquinone methyltransferase AMETH_2208 ENOG4105F0K SARP family transcriptional regulator AMETH_2220 ENOG4107S9F NmrA family AMETH_2221 ENOG4107S9F NmrA family AMETH_2224 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AMETH_2226 ENOG4105ECP epimerase AMETH_2228 ENOG4105ETE Transcriptional regulator (LacI family AMETH_2231 ENOG4105CSH Transporter AMETH_2234 ENOG4105C26 Dehydrogenase AMETH_2239 ENOG4105CSH Transporter AMETH_2242 ENOG4105CMT Dihydroxyacetone kinase AMETH_2243 ENOG4107YVI ribose 5-phosphate isomerase AMETH_2248 ENOG4105CSH Transporter AMETH_2249 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_2250 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_2251 ENOG4105WAB arsR family transcriptional regulator AMETH_2252 ENOG4105DEN Luciferase family AMETH_2257 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_2266 ENOG4108RVA ribokinase AMETH_2268 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_2269 ENOG4105CI0 Citrate lyase AMETH_2285 ENOG4105E1F short-chain dehydrogenase reductase AMETH_2294 ENOG4105CNA YD repeat protein AMETH_2295 ENOG4105MC2 DSBA oxidoreductase AMETH_2298 ENOG4108IUX (ABC) transporter AMETH_2301 ENOG4105CGK Exodeoxyribonuclease III AMETH_2302 ENOG4105DZQ phospholipase D Transphosphatidylase AMETH_2305 ENOG4105EA8 2-Nitropropane dioxygenase AMETH_2308 ENOG4107YPT transcriptional regulator AMETH_2310 ENOG4105DYW oxidoreductase AMETH_2312 ENOG4105C5H ABC transporter AMETH_2318 ENOG4108KPJ rna polymerase sigma factor AMETH_2322 ENOG4105CHR reductase AMETH_2337 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AMETH_2338 ENOG4105MWK D-amino acid dehydrogenase, small subunit AMETH_2346 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_2348 ENOG4107RN3 metallophosphoesterase AMETH_2349 ENOG4105DU1 integral membrane protein, terc AMETH_2352 ENOG4106IPI cyclase, family AMETH_2353 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AMETH_2357 ENOG4105EMU Dehydrogenase AMETH_2358 ENOG4108QBF Transcriptional regulator AMETH_2359 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AMETH_2361 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) AMETH_2364 ENOG4105CHR reductase AMETH_2370 ENOG4105CKQ methane phenol toluene hydroxylase AMETH_2371 ENOG4108ZFP monooxygenase component MmoB DmpM AMETH_2375 ENOG41070H7 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AMETH_2376 ENOG4105CGU Enoyl-CoA hydratase AMETH_2379 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_2384 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AMETH_2386 ENOG4105CPP Dehydrogenase, E1 component AMETH_2387 ENOG4107RUY (E1 component), alpha subunit AMETH_2391 ENOG4105DZY Pts system, glucitol sorbitol-specific AMETH_2392 ENOG410787A Pts system, glucitol sorbitol-specific AMETH_2393 ENOG410849S phosphocarrier protein (HPr) AMETH_2394 ENOG4105DKT Transcriptional regulator AMETH_2395 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AMETH_2401 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AMETH_2405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AMETH_2406 ENOG4105BZU Histidine kinase AMETH_2409 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) AMETH_2411 ENOG4107UB2 Alpha beta hydrolase fold AMETH_2412 ENOG4105MXW flavin reductase domain protein, FMN-binding AMETH_2413 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AMETH_2428 ENOG41076PI Short-chain dehydrogenase reductase Sdr AMETH_2429 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AMETH_2431 ENOG4105FQP Beta-lactamase AMETH_2432 ENOG4105DZC cytosine deaminase AMETH_2443 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) AMETH_2446 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AMETH_2448 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AMETH_2451 ENOG4108W6C Dehydrogenase AMETH_2456 ENOG4105SFS phosphoesterase RecJ domain protein AMETH_2459 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AMETH_2463 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AMETH_2464 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AMETH_2465 ENOG4105C1V Peptidase, M16 AMETH_2466 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AMETH_2469 ENOG4105CPC Aldo Keto reductase AMETH_2475 ENOG4105T0Z Conserved Protein AMETH_2481 ENOG4105D9P serine threonine protein kinase AMETH_2482 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AMETH_2483 ENOG4105CN5 Metallo-Beta-Lactamase AMETH_2485 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AMETH_2488 ENOG4105CSH Transporter AMETH_2492 ENOG4107QZI cell division protein FtsK AMETH_2495 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AMETH_2497 ENOG4105CEV competence damage-inducible protein AMETH_2498 ENOG4105WBV Transcriptional regulator AMETH_2502 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AMETH_2505 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) AMETH_2508 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AMETH_2510 ENOG4105ETE Transcriptional regulator (LacI family AMETH_2513 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AMETH_2518 ENOG4108V6E Cell division protein mraZ AMETH_2519 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AMETH_2521 ENOG4105CJN penicillin-binding protein AMETH_2522 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AMETH_2524 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AMETH_2525 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AMETH_2528 ENOG4105DFU Cell wall formation (By similarity) AMETH_2529 ENOG4105ME9 cell division protein FtsQ AMETH_2536 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AMETH_2541 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_2544 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AMETH_2546 ENOG4108ZHR arsR family transcriptional regulator AMETH_2547 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AMETH_2548 ENOG4105C9B Cysteine desulfurase AMETH_2551 ENOG4105KME endoribonuclease L-psp AMETH_2555 ENOG4105DYW oxidoreductase AMETH_2562 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AMETH_2565 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AMETH_2569 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AMETH_2573 ENOG4105C1B dTDP-glucose 4-6-dehydratase AMETH_2575 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AMETH_2576 ENOG4105DKP glycosyl transferase, family 9 AMETH_2577 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AMETH_2578 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AMETH_2580 ENOG4105D16 lipopolysaccharide heptosyltransferase i AMETH_2581 ENOG4105C6Y Udp-glucose 6-dehydrogenase AMETH_2587 ENOG4105BZ9 Cytochrome C oxidase, subunit I AMETH_2597 ENOG4107EJG GntR family transcriptional regulator AMETH_2598 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AMETH_2602 ENOG4107TB5 TRANSCRIPTIONal AMETH_2605 ENOG4106T9R serine protease AMETH_2607 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AMETH_2620 ENOG4105CJ1 ABC, transporter AMETH_2621 ENOG4105DU1 integral membrane protein, terc AMETH_2622 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AMETH_2625 ENOG4105C2J ABC transporter AMETH_2626 ENOG4105CNN ABC, transporter AMETH_2627 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AMETH_2628 ENOG4105ETE Transcriptional regulator (LacI family AMETH_2629 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) AMETH_2630 ENOG4105CMG Carbohydrate kinase AMETH_2631 ENOG4105KT7 mgtC SapB transporter AMETH_2636 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein AMETH_2637 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AMETH_2645 ENOG4105C26 Dehydrogenase AMETH_2650 ENOG4105C5X domain protein AMETH_2657 ENOG4107QJT sodium dicarboxylate symporter AMETH_2658 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AMETH_2659 ENOG4108MRH transcriptional regulatory protein AMETH_2660 ENOG41082VC UPF0145 protein AMETH_2661 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AMETH_2662 ENOG4105C6Z Gluconate AMETH_2666 ENOG4105KME endoribonuclease L-psp AMETH_2669 ENOG41084BS 50S ribosomal protein L35 AMETH_2670 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AMETH_2671 ENOG4108RWN rrna methyltransferase AMETH_2672 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AMETH_2673 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AMETH_2677 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AMETH_2678 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AMETH_2679 ENOG4105CAS nag kinase AMETH_2680 ENOG4105C8Y Acetylornithine aminotransferase AMETH_2681 ENOG4105DBV ornithine carbamoyltransferase AMETH_2683 ENOG4105CH7 arginosuccinase AMETH_2685 ENOG4108VX5 3-methyladenine DNA glycosylase AMETH_2686 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AMETH_2688 ENOG4105DSU hydrolase AMETH_2691 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AMETH_2698 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AMETH_2699 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AMETH_2700 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AMETH_2705 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AMETH_2707 ENOG4105C9U ATP-dependent DNA helicase RecQ AMETH_2708 ENOG4108222 arsenate reductase AMETH_2709 ENOG4107S91 Sodium hydrogen exchanger AMETH_2711 ENOG4105CAT Cytidine monophosphate kinase AMETH_2713 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AMETH_2716 ENOG4105DFW ABC transporter AMETH_2717 ENOG4105C2J ABC transporter AMETH_2718 ENOG4108HWW ABC transporter AMETH_2731 ENOG4108M0I Transcriptional regulator AMETH_2732 ENOG4105D4T Citrate transporter AMETH_2739 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AMETH_2741 ENOG4105Q56 cytochrome P450 AMETH_2743 ENOG4107HP6 Transcriptional regulator AMETH_2744 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AMETH_2746 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AMETH_2747 ENOG4105E2Y ABC, transporter AMETH_2748 ENOG4105GVF (ABC) transporter AMETH_2749 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AMETH_2751 ENOG41062BK proline dehydrogenase AMETH_2752 ENOG4105C26 Dehydrogenase AMETH_2753 ENOG4108K8K Transcriptional regulator AMETH_2756 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AMETH_2757 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) AMETH_2758 ENOG4105CG3 alpha amylase, catalytic region AMETH_2759 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) AMETH_2769 ENOG4105PNM synthesis protein AMETH_2773 ENOG4105DKQ ROK family AMETH_2776 ENOG4105C2J ABC transporter AMETH_2777 ENOG4105CNN ABC, transporter AMETH_2778 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AMETH_2781 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase AMETH_2788 ENOG4107XBN GntR Family Transcriptional Regulator AMETH_2789 ENOG4105C02 permease AMETH_2790 ENOG4107ZYJ bioY protein AMETH_2792 ENOG4105CHU acetyl-coa acetyltransferase AMETH_2793 ENOG4108JJB ABC transporter AMETH_2796 ENOG4105CXN decarboxylase AMETH_2802 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AMETH_2804 ENOG4105CPQ Dehydrogenase AMETH_2805 ENOG4105C3R Methionine synthase AMETH_2810 ENOG4105C93 Xylose Isomerase AMETH_2811 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AMETH_2816 ENOG4105DRR Transcriptional regulator, GntR family AMETH_2821 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_2824 ENOG4105CNQ glycine cleavage T protein, aminomethyl transferase AMETH_2825 ENOG4105JSC dimethylmenaquinone methyltransferase AMETH_2834 ENOG4105CN8 Transcriptional regulator AMETH_2836 ENOG410829K Lysine exporter protein (Lyse ygga) AMETH_2838 ENOG4105KF0 sporulation and cell division protein, SsgA AMETH_2840 ENOG4105D3Q Sugar transferase AMETH_2844 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AMETH_2846 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AMETH_2851 ENOG4105EQK -acetyltransferase AMETH_2856 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) AMETH_2857 ENOG4105C22 threonyL-tRNA synthetase AMETH_2860 ENOG41090MY MarR family Transcriptional regulator AMETH_2862 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase AMETH_2863 ENOG4105E2K Glycosyl transferase (Group 1 AMETH_2865 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family AMETH_2868 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AMETH_2869 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AMETH_2870 ENOG4105CDY transcriptional regulatory protein AMETH_2872 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AMETH_2873 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AMETH_2874 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AMETH_2877 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AMETH_2878 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AMETH_2879 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AMETH_2885 ENOG4105KF0 sporulation and cell division protein, SsgA AMETH_2888 ENOG4105BZ4 penicillin-binding protein AMETH_2890 ENOG4105GFG DUF218 domain AMETH_2893 ENOG4107QK5 Homocysteine s-methyltransferase AMETH_2895 ENOG4105JZI cytochrome P450 AMETH_2898 ENOG4105EBR Carboxylesterase AMETH_2902 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_2904 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AMETH_2905 ENOG4105EXC Acyl-transferase AMETH_2909 ENOG4105EHG Permease protein AMETH_2910 ENOG4105E0A ABC, transporter AMETH_2930 ENOG4108J2P Alpha beta hydrolase fold AMETH_2937 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_2938 ENOG4105DQ4 alcohol dehydrogenase AMETH_2943 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AMETH_2944 ENOG4105ERH Fumarylacetoacetate hydrolase AMETH_2945 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_2952 ENOG4105CP9 extracellular ligand-binding receptor AMETH_2953 ENOG4105C32 Amino acid ABC transporter (Permease) AMETH_2954 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AMETH_2955 ENOG4105C0Z ABC transporter AMETH_2956 ENOG4108IV0 ABC, transporter AMETH_2960 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AMETH_2962 ENOG4105CHP RNA polymerase AMETH_2965 ENOG4108IG5 Transcriptional regulator AMETH_2966 ENOG4105ECB domain protein AMETH_2969 ENOG4107SK7 Sarcosine-dimethylglycine methyltransferase AMETH_2970 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AMETH_2972 ENOG4105EEI dihydropteroate synthase AMETH_2979 ENOG4105DYW oxidoreductase AMETH_2980 ENOG4107R72 Ceramidase AMETH_2981 ENOG4105CT4 transporter AMETH_2983 ENOG4105CKI cobalamin synthesis protein AMETH_2984 ENOG4108BT0 50S ribosomal protein L32 AMETH_2985 ENOG4105NRA 50s ribosomal protein l31 type b AMETH_2987 ENOG4105KDC 50s ribosomal protein l28 AMETH_2988 ENOG4105W0E 50S ribosomal protein L33 AMETH_2989 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AMETH_2990 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AMETH_2992 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AMETH_2995 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_3000 ENOG4108UW8 fha domain-containing protein AMETH_3011 ENOG4105D1K glutamate--cysteine ligase AMETH_3012 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process AMETH_3013 ENOG4108V75 Glutamine amidotransferase AMETH_3014 ENOG41067HS methyltransferase AMETH_3018 ENOG4105CHP RNA polymerase AMETH_3019 ENOG4107WA4 MmpL domain-containing protein AMETH_3020 ENOG4107QM5 aconitate hydratase AMETH_3023 ENOG4105ZXU NLP P60 protein AMETH_3024 ENOG410801B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AMETH_3025 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AMETH_3027 ENOG4107QVM von Willebrand factor, type A AMETH_3030 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AMETH_3031 ENOG4105DGI Alkaline phosphatase AMETH_3032 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_3035 ENOG4105E0F Histidine kinase AMETH_3036 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AMETH_3037 ENOG4105CSH Transporter AMETH_3039 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AMETH_3040 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AMETH_3043 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AMETH_3044 ENOG4108YV4 Universal stress protein AMETH_3045 ENOG4107QRI Phosphoketolase AMETH_3046 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AMETH_3056 ENOG4105CSR polyphosphate kinase 2 AMETH_3066 ENOG4105C7W Xanthine dehydrogenase AMETH_3068 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AMETH_3072 ENOG41082BM Transcriptional regulator, arsr family AMETH_3073 ENOG41083YR Protein CrcB homolog AMETH_3074 ENOG4105KJJ Uncharacterized ACR, COG1993 AMETH_3083 ENOG4105CSH Transporter AMETH_3086 ENOG4105C1G acyl-Coa dehydrogenase AMETH_3087 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_3089 ENOG4105EP8 Glycosyl Hydrolase Family 88 AMETH_3090 ENOG4105BZU Histidine kinase AMETH_3091 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_3093 ENOG4105CSH Transporter AMETH_3094 ENOG4105E2A Dehydrogenase AMETH_3096 ENOG4105C0X amino acid AMETH_3101 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AMETH_3102 ENOG4105ETS cytosine purines uracil thiamine allantoin AMETH_3103 ENOG4105CN2 monooxygenase, FAD-binding AMETH_3106 ENOG4105CFM UPF0317 protein AMETH_3109 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AMETH_3111 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AMETH_3112 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AMETH_3113 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AMETH_3115 ENOG4105DKQ ROK family AMETH_3116 ENOG4105RD7 BadF BadG BcrA BcrD AMETH_3120 ENOG4105CK7 Sodium proline symporter AMETH_3123 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AMETH_3126 ENOG4105D5G Transposase AMETH_3128 ENOG4105DK2 UPF0207 protein AMETH_3140 ENOG41082BM Transcriptional regulator, arsr family AMETH_3141 ENOG41089UC methyltransferase, type 11 AMETH_3143 ENOG4105H3G oxidoreductase AMETH_3146 ENOG4108Z7F N-acetyltransferase AMETH_3154 ENOG4108594 Permease of the drug metabolite transporter AMETH_3159 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_3164 ENOG4105CD3 dihydroorotase AMETH_3165 ENOG4105CSH Transporter AMETH_3168 ENOG4105C26 Dehydrogenase AMETH_3169 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AMETH_3171 ENOG4105CGU Enoyl-CoA hydratase AMETH_3177 ENOG4105CC9 acyl-Coa dehydrogenase AMETH_3178 ENOG4108KC2 acyl-Coa dehydrogenase AMETH_3182 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_3183 ENOG4105CHR reductase AMETH_3185 ENOG4105D2B acyl-CoA dehydrogenase AMETH_3186 ENOG4105CC9 acyl-Coa dehydrogenase AMETH_3187 ENOG4105DRR Transcriptional regulator, GntR family AMETH_3191 ENOG4105CHU acetyl-coa acetyltransferase AMETH_3192 ENOG4105EA8 2-Nitropropane dioxygenase AMETH_3198 ENOG4105FUY alpha subunit AMETH_3199 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AMETH_3205 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_3207 ENOG4105CY3 ABC transporter, permease AMETH_3208 ENOG4105CY3 ABC transporter, permease AMETH_3209 ENOG4105DHJ ABC, transporter AMETH_3222 ENOG4108UKI Enoyl-CoA hydratase AMETH_3230 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AMETH_3232 ENOG4105D2N Aldolase AMETH_3240 ENOG4105VG1 fes assembly suf system protein AMETH_3245 ENOG4105VPX protein, conserved in bacteria AMETH_3248 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AMETH_3249 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AMETH_3250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AMETH_3254 ENOG4105GVJ transcriptional regulator AMETH_3270 ENOG41061ZR Transcriptional regulator AMETH_3270 ENOG41061ZR Transcriptional regulator AMETH_3273 ENOG4105BZP glycoside hydrolase 15-related AMETH_3278 ENOG4105DSF transport protein AMETH_3281 ENOG4105CSR polyphosphate kinase 2 AMETH_3282 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AMETH_3284 ENOG4105C7B Threonine dehydratase AMETH_3285 ENOG4108MWI inositol mono-phosphatase AMETH_3286 ENOG4107QJN gtp cyclohydrolase ii AMETH_3289 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AMETH_3296 ENOG4105FP9 thiamine pyrophosphate AMETH_3297 ENOG4105D2S major facilitator superfamily AMETH_3300 ENOG4105C94 Transporter AMETH_3301 ENOG4108VQR secreted hydrolase AMETH_3307 ENOG4105RHY Pfam:UPF0157 AMETH_3311 ENOG4105WAB arsR family transcriptional regulator AMETH_3313 ENOG4105EUB pirin domain protein AMETH_3315 ENOG4105CHP RNA polymerase AMETH_3318 ENOG4107YB1 Trehalose corynomycolyl transferase AMETH_3332 ENOG4105ETE Transcriptional regulator (LacI family AMETH_3336 ENOG4105K56 Transcriptional regulator AMETH_3337 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction AMETH_3339 ENOG4105K56 Transcriptional regulator AMETH_3340 ENOG4105EFZ amidohydrolase AMETH_3344 ENOG4105F95 Monooxygenase AMETH_3357 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_3360 ENOG4105CV8 reductase AMETH_3361 ENOG4105F27 Major Facilitator AMETH_3370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AMETH_3371 ENOG4105C3U ABC transporter AMETH_3373 ENOG4105CHR reductase AMETH_3378 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AMETH_3396 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AMETH_3397 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AMETH_3398 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AMETH_3401 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AMETH_3404 ENOG410846T CoA-transferase family III AMETH_3408 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AMETH_3415 ENOG4105CPC Aldo Keto reductase AMETH_3416 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AMETH_3418 ENOG4105DGW oligopeptidase A AMETH_3421 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AMETH_3428 ENOG4108Z4X TRANSCRIPTIONal AMETH_3431 ENOG4108J59 Extracellular solute-binding protein, family 5 AMETH_3432 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AMETH_3433 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AMETH_3434 ENOG4108JQ6 ABC transporter AMETH_3435 ENOG41090CE integral membrane protein AMETH_3437 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AMETH_3438 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AMETH_3441 ENOG4105EMN RNA polymerase sigma factor AMETH_3455 ENOG4105CSH Transporter AMETH_3458 ENOG4108KPJ rna polymerase sigma factor AMETH_3470 ENOG4107ZT3 family UPF0126 AMETH_3472 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AMETH_3473 ENOG4106NZI LysR family Transcriptional regulator AMETH_3475 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AMETH_3478 ENOG4105DRR Transcriptional regulator, GntR family AMETH_3485 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AMETH_3491 ENOG4107W53 thymidine kinase AMETH_3494 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AMETH_3496 ENOG4105CI2 imidazolone-5-propionate hydrolase AMETH_3497 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AMETH_3507 ENOG4105J0Q Transcriptional regulator AMETH_3513 ENOG4108IUX (ABC) transporter AMETH_3515 ENOG4105CHR reductase AMETH_3516 ENOG4105EMU Dehydrogenase AMETH_3528 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AMETH_3530 ENOG4107TMB Transcriptional regulator AMETH_3531 ENOG4108FFZ Transcriptional regulator AMETH_3533 ENOG4107R13 MMPL domain protein AMETH_3535 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) AMETH_3536 ENOG4105DDN Pentapeptide repeat-containing protein AMETH_3537 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AMETH_3538 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AMETH_3539 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) AMETH_3540 ENOG4105E5F proteasome AMETH_3541 ENOG4105PTV Nudix Hydrolase AMETH_3546 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) AMETH_3555 ENOG4105CHP RNA polymerase AMETH_3556 ENOG4105GRZ Ycii-related protein AMETH_3559 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AMETH_3560 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase AMETH_3561 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AMETH_3562 ENOG4105C3R Methionine synthase AMETH_3568 ENOG4105C8N cysteinyl-tRNA synthetase AMETH_3575 ENOG4107KWJ von Willebrand factor, type A AMETH_3577 ENOG4108UF8 AMETH_3583 ENOG4105CI2 imidazolone-5-propionate hydrolase AMETH_3587 ENOG4105DQE DNA ligase AMETH_3590 ENOG41073TP transcriptional regulator AMETH_3592 ENOG4105ERH Fumarylacetoacetate hydrolase AMETH_3593 ENOG4105DIA mandelate racemase muconate lactonizing AMETH_3596 ENOG4105C2J ABC transporter AMETH_3597 ENOG4105CNN ABC, transporter AMETH_3599 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AMETH_3605 ENOG4105EYF MMPL domain protein AMETH_3607 ENOG4105KHM amidohydrolase 2 AMETH_3608 ENOG4105GAK amidohydrolase 2 AMETH_3615 ENOG4105C57 major facilitator superfamily AMETH_3625 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AMETH_3629 ENOG4105ERH Fumarylacetoacetate hydrolase AMETH_3632 ENOG4105D2S major facilitator superfamily AMETH_3636 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AMETH_3639 ENOG4105C0R drug resistance transporter emrb qaca subfamily AMETH_3641 ENOG4105H3G oxidoreductase AMETH_3649 ENOG4105C3M thioredoxin reductase AMETH_3655 ENOG4105XTG Pfam:DUF156 AMETH_3660 ENOG4108YV4 Universal stress protein AMETH_3665 ENOG4105CPP Dehydrogenase, E1 component AMETH_3671 ENOG4105DTD Dehydrogenase AMETH_3672 ENOG4108UKI Enoyl-CoA hydratase AMETH_3673 ENOG4105C1G acyl-Coa dehydrogenase AMETH_3675 ENOG4105NAE bifunctional deaminase-reductase domain protein AMETH_3677 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AMETH_3679 ENOG4105C01 Dihydroxy-acid dehydratase AMETH_3680 ENOG4107EFR Flavocytochrome c AMETH_3683 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AMETH_3684 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AMETH_3688 ENOG4105BZU Histidine kinase AMETH_3689 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_3692 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AMETH_3696 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_3697 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AMETH_3699 ENOG4108Z0R Transferase AMETH_3700 ENOG4105C1J atp-dependent rna helicase AMETH_3701 ENOG4105C57 major facilitator superfamily AMETH_3702 ENOG41064MX Tetr family transcriptional regulator AMETH_3709 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) AMETH_3711 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) AMETH_3715 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth AMETH_3726 ENOG4108UW5 maltose o-acetyltransferase AMETH_3728 ENOG4105CSH Transporter AMETH_3729 ENOG4105CH2 amidohydrolase AMETH_3733 ENOG4108KPJ rna polymerase sigma factor AMETH_3735 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AMETH_3736 ENOG4108K8U Glycerol operon regulatory protein AMETH_3737 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AMETH_3738 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AMETH_3739 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AMETH_3745 ENOG4105DUX Transporter AMETH_3746 ENOG4105CI2 imidazolone-5-propionate hydrolase AMETH_3750 ENOG4105C26 Dehydrogenase AMETH_3751 ENOG4108SC4 )-transporter AMETH_3756 ENOG4105CHU acetyl-coa acetyltransferase AMETH_3763 ENOG4105CHR reductase AMETH_3765 ENOG4105C0R drug resistance transporter emrb qaca subfamily AMETH_3768 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_3778 ENOG4105SHT UspA domain-containing protein AMETH_3779 ENOG4107QNK )-transporter AMETH_3780 ENOG4105F0H myo-inositol catabolism protein AMETH_3781 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AMETH_3782 ENOG4105C26 Dehydrogenase AMETH_3785 ENOG4105KKX ATPase associated with various cellular activities aaa_5 AMETH_3787 ENOG4105DEG Vwa containing coxe family protein AMETH_3790 ENOG4105CDH Citrulline--aspartate ligase AMETH_3797 ENOG4108WYP Transcriptional regulator AMETH_3799 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F AMETH_3800 ENOG4105C1G acyl-Coa dehydrogenase AMETH_3801 ENOG4108M9J MaoC like domain protein AMETH_3803 ENOG4105CIR epoxide hydrolase AMETH_3805 ENOG4108HMN Caspase domain AMETH_3808 ENOG4107258 Transcriptional regulator AMETH_3809 ENOG4108JQ1 Dehydrogenase AMETH_3810 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AMETH_3811 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_3812 ENOG4105C6Z Gluconate AMETH_3815 ENOG4105VMP Transcriptional regulator AMETH_3817 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component AMETH_3823 ENOG4105EBM Alpha Beta Hydrolase Fold protein AMETH_3835 ENOG4105ECQ AraC Family Transcriptional Regulator AMETH_3839 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AMETH_3840 ENOG4105CRK lysyL-tRNA synthetase AMETH_3842 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AMETH_3843 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AMETH_3844 ENOG41062D9 Histidine kinase AMETH_3852 ENOG4105CQB FAD linked oxidase domain protein AMETH_3853 ENOG4105CQB FAD linked oxidase domain protein AMETH_3854 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AMETH_3855 ENOG4105DAA L-lactate AMETH_3856 ENOG4105F8D glycoside hydrolase family 4 AMETH_3858 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AMETH_3875 ENOG4105C26 Dehydrogenase AMETH_3876 ENOG4105F95 Monooxygenase AMETH_3879 ENOG4105C26 Dehydrogenase AMETH_3880 ENOG4105CPQ Dehydrogenase AMETH_3881 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_3886 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AMETH_3888 ENOG4105CIG ABC transporter AMETH_3894 ENOG4105C26 Dehydrogenase AMETH_3895 ENOG4105CSH Transporter AMETH_3896 ENOG4108K8K Transcriptional regulator AMETH_3897 ENOG4105DTQ mandelate racemase muconate lactonizing AMETH_3902 ENOG4105C3U ABC transporter AMETH_3903 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AMETH_3906 ENOG4105E1F short-chain dehydrogenase reductase AMETH_3907 ENOG4105C01 Dihydroxy-acid dehydratase AMETH_3911 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AMETH_3913 ENOG4107QRT dEAD DEAH box helicase AMETH_3918 ENOG4105ETE Transcriptional regulator (LacI family AMETH_3919 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AMETH_3920 ENOG41079KZ Major Facilitator Superfamily AMETH_3923 ENOG4105D3G Pseudouridine synthase AMETH_3927 ENOG4105CPU Monooxygenase AMETH_3929 ENOG4105CPC Aldo Keto reductase AMETH_3930 ENOG4105CPC Aldo Keto reductase AMETH_3935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AMETH_3937 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AMETH_3943 ENOG4108UAU isochorismatase AMETH_3948 ENOG41079KZ Major Facilitator Superfamily AMETH_3955 ENOG4105CIR epoxide hydrolase AMETH_3957 ENOG4108KTG Membrane protein, drug metabolite transporter AMETH_3958 ENOG4105DND Transcriptional regulator AMETH_3964 ENOG4105EIG urea carboxylase-associated protein 1 AMETH_3966 ENOG4108FKH Transglycosylase SLT domain AMETH_3967 ENOG4105ETE Transcriptional regulator (LacI family AMETH_3969 ENOG4105CSP Major Facilitator Superfamily AMETH_3971 ENOG4105CXK mandelate racemase muconate lactonizing AMETH_3976 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AMETH_3982 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AMETH_3989 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AMETH_3990 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_3994 ENOG4105DZS Phenylacetate-CoA ligase AMETH_3996 ENOG4105C26 Dehydrogenase AMETH_3997 ENOG4105CSH Transporter AMETH_3999 ENOG4105CHR reductase AMETH_4000 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_4001 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_4005 ENOG4105CPQ Dehydrogenase AMETH_4010 ENOG4105DCG PHP domain protein AMETH_4016 ENOG4108VJY integral membrane protein AMETH_4017 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AMETH_4018 ENOG4107SET aldo keto reductase AMETH_4024 ENOG4105D2B acyl-CoA dehydrogenase AMETH_4025 ENOG4105D2B acyl-CoA dehydrogenase AMETH_4026 ENOG4108IG5 Transcriptional regulator AMETH_4027 ENOG4105CHR reductase AMETH_4028 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AMETH_4029 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AMETH_4030 ENOG4105CIR epoxide hydrolase AMETH_4037 ENOG4108IG5 Transcriptional regulator AMETH_4040 ENOG4107QX3 carboxylase AMETH_4041 ENOG4105C1G acyl-Coa dehydrogenase AMETH_4044 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AMETH_4045 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AMETH_4051 ENOG4108KGH TRANSCRIPTIONal AMETH_4053 ENOG4108SU4 UPF0309 protein AMETH_4054 ENOG4105BZ1 (ABC) transporter AMETH_4057 ENOG4105C5H ABC transporter AMETH_4058 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AMETH_4061 ENOG4105VG1 fes assembly suf system protein AMETH_4062 ENOG4108UNV SUF system FeS assembly protein, NifU family AMETH_4064 ENOG4105C3K feS assembly ATPase SufC AMETH_4068 ENOG4107JC6 Membrane AMETH_4069 ENOG4105CJ1 ABC, transporter AMETH_4074 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AMETH_4077 ENOG4105EWU Squalene--hopene cyclase AMETH_4079 ENOG4107S11 squalene-associated FAD-dependent desaturase AMETH_4083 ENOG4107S4F acyltransferase, ws dgat mgat AMETH_4087 ENOG4105PP6 Membrane AMETH_4088 ENOG4108W6C Dehydrogenase AMETH_4090 ENOG4105EEM helicase AMETH_4091 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AMETH_4093 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AMETH_4097 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) AMETH_4099 ENOG4105BZU Histidine kinase AMETH_4102 ENOG4105CP7 Triose-phosphate isomerase AMETH_4103 ENOG4105BZA Phosphoglycerate kinase AMETH_4104 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AMETH_4107 ENOG410829K Lysine exporter protein (Lyse ygga) AMETH_4113 ENOG41067TZ transcriptional regulator, MarR family AMETH_4116 ENOG4105C3Q Glycosyl transferase, family 2 AMETH_4118 ENOG4105BZU Histidine kinase AMETH_4119 ENOG4108KXV response regulator AMETH_4121 ENOG4105CIE May be required for sporulation (By similarity) AMETH_4123 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AMETH_4124 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AMETH_4127 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AMETH_4128 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AMETH_4133 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AMETH_4134 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AMETH_4137 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AMETH_4139 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AMETH_4140 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AMETH_4142 ENOG4105SKN orotidine 5''-phosphate decarboxylase AMETH_4144 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AMETH_4147 ENOG4105CXT aspartate transcarbamylase AMETH_4148 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AMETH_4150 ENOG410803B Involved in the transcription termination process (By similarity) AMETH_4151 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AMETH_4155 ENOG4105D9U N-acetyltransferase AMETH_4156 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AMETH_4157 ENOG4105D49 3-dehydroquinate synthase AMETH_4158 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AMETH_4159 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AMETH_4160 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AMETH_4166 ENOG4105C5Y PTS System AMETH_4167 ENOG4105CI1 PTS System AMETH_4168 ENOG4105FDP GntR family transcriptional regulator AMETH_4169 ENOG4105CI1 PTS System AMETH_4170 ENOG410849S phosphocarrier protein (HPr) AMETH_4171 ENOG4107QK9 Beta-lactamase AMETH_4175 ENOG4105E2X shikimate dehydrogenase AMETH_4178 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AMETH_4186 ENOG4105C9M aspartyl-trna synthetase AMETH_4190 ENOG4107YPT transcriptional regulator AMETH_4191 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AMETH_4195 ENOG4105ECR NmrA family AMETH_4196 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase AMETH_4199 ENOG4108V06 Glutathione peroxidase AMETH_4203 ENOG4105CEP NADH dehydrogenase AMETH_4204 ENOG4108I0Z Aconitate hydratase AMETH_4205 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AMETH_4207 ENOG4105CH2 amidohydrolase AMETH_4210 ENOG4105DUM transcriptional regulator, lysR family AMETH_4213 ENOG4107HP6 Transcriptional regulator AMETH_4219 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_4221 ENOG4105C0R drug resistance transporter emrb qaca subfamily AMETH_4231 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AMETH_4236 ENOG4105CND Glycosyl transferase, family 2 AMETH_4240 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_4243 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AMETH_4247 ENOG4105ERH Fumarylacetoacetate hydrolase AMETH_4254 ENOG4105D5Q Arginine ornithine antiporter AMETH_4256 ENOG4105CSH Transporter AMETH_4258 ENOG4107RSM transcriptional regulator AMETH_4261 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AMETH_4262 ENOG4105C1G acyl-Coa dehydrogenase AMETH_4263 ENOG4108UZX fmn reductase AMETH_4269 ENOG4105VEQ Cold shock protein AMETH_4271 ENOG4105CIB oxidoreductase Domain protein AMETH_4283 ENOG4105CMT Dihydroxyacetone kinase AMETH_4284 ENOG4107258 Transcriptional regulator AMETH_4288 ENOG4105J0Q Transcriptional regulator AMETH_4290 ENOG4105CSH Transporter AMETH_4306 ENOG4105EHG Permease protein AMETH_4311 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_4316 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein AMETH_4319 ENOG41070H7 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AMETH_4324 ENOG4105CKQ methane phenol toluene hydroxylase AMETH_4325 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein AMETH_4330 ENOG4105YVS arsR family transcriptional regulator AMETH_4331 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AMETH_4343 ENOG4105E2B Taurine dioxygenase AMETH_4344 ENOG4105MXB limonene-12-epoxide hydrolase AMETH_4347 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AMETH_4350 ENOG4108ZJ4 polysaccharide deacetylase AMETH_4351 ENOG4108HW3 (ABC) transporter AMETH_4356 ENOG4108M8W Monooxygenase AMETH_4357 ENOG4105EBR Carboxylesterase AMETH_4359 ENOG4105GWZ Roadblock lc7 family protein AMETH_4362 ENOG4105BZU Histidine kinase AMETH_4369 ENOG4105CHP RNA polymerase AMETH_4370 ENOG4105GRZ Ycii-related protein AMETH_4371 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AMETH_4378 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AMETH_4387 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AMETH_4389 ENOG4105E1F short-chain dehydrogenase reductase AMETH_4393 ENOG4105CIR epoxide hydrolase AMETH_4397 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_4398 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AMETH_4402 ENOG4105HSS phospholipase C AMETH_4405 ENOG4105GWZ Roadblock lc7 family protein AMETH_4408 ENOG4105C0F tryptophanase EC 4.1.99.1 AMETH_4411 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase AMETH_4412 ENOG4105K5B UPF0225 protein AMETH_4419 ENOG4105DJB Major Facilitator Superfamily AMETH_4426 ENOG4107RR1 TRANSCRIPTIONal AMETH_4427 ENOG4105F95 Monooxygenase AMETH_4432 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AMETH_4434 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AMETH_4450 ENOG41089UC methyltransferase, type 11 AMETH_4454 ENOG4105CNW domain protein AMETH_4455 ENOG4105D2B acyl-CoA dehydrogenase AMETH_4457 ENOG4105CC9 acyl-Coa dehydrogenase AMETH_4459 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_4460 ENOG4105CC9 acyl-Coa dehydrogenase AMETH_4462 ENOG4105F2C Acetyl-CoA acetyltransferase AMETH_4463 ENOG4105EA8 2-Nitropropane dioxygenase AMETH_4466 ENOG41060WC Enoyl-CoA hydratase AMETH_4467 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr AMETH_4470 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AMETH_4472 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AMETH_4479 ENOG4105C94 Transporter AMETH_4480 ENOG4105DVW rieske (2Fe-2S) AMETH_4481 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AMETH_4488 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AMETH_4489 ENOG4105EEI dihydropteroate synthase AMETH_4491 ENOG4105EJQ L-serine dehydratase AMETH_4493 ENOG4107HP6 Transcriptional regulator AMETH_4494 ENOG4105VQD rieske 2fe-2S domain-containing protein AMETH_4495 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AMETH_4496 ENOG4108RFG Tetr family transcriptional regulator AMETH_4497 ENOG4105C26 Dehydrogenase AMETH_4502 ENOG4105C1G acyl-Coa dehydrogenase AMETH_4503 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F AMETH_4504 ENOG4105CHU acetyl-coa acetyltransferase AMETH_4505 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_4506 ENOG41082A2 Alpha beta hydrolase AMETH_4507 ENOG410900P UPF0336 protein AMETH_4508 ENOG4105CSH Transporter AMETH_4513 ENOG4105BZ9 Cytochrome C oxidase, subunit I AMETH_4514 ENOG4105BZ9 Cytochrome C oxidase, subunit I AMETH_4522 ENOG4105DY9 regulatoR AMETH_4524 ENOG4105DZG Dehydrogenase AMETH_4526 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AMETH_4531 ENOG4107R1Y fructose-bisphosphate aldolase AMETH_4532 ENOG4105DUM transcriptional regulator, lysR family AMETH_4534 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AMETH_4537 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) AMETH_4546 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr AMETH_4548 ENOG4105E39 Enoyl-CoA hydratase AMETH_4551 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_4552 ENOG4105E39 Enoyl-CoA hydratase AMETH_4553 ENOG4105CHU acetyl-coa acetyltransferase AMETH_4555 ENOG4105CHR reductase AMETH_4556 ENOG4105C1G acyl-Coa dehydrogenase AMETH_4563 ENOG4105C26 Dehydrogenase AMETH_4580 ENOG4105CY3 ABC transporter, permease AMETH_4583 ENOG4107W6X Transcriptional regulator AMETH_4584 ENOG4105C26 Dehydrogenase AMETH_4585 ENOG4105CPQ Dehydrogenase AMETH_4586 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AMETH_4587 ENOG4105CSH Transporter AMETH_4590 ENOG4105DTQ mandelate racemase muconate lactonizing AMETH_4593 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AMETH_4596 ENOG41079KZ Major Facilitator Superfamily AMETH_4597 ENOG4105ETE Transcriptional regulator (LacI family AMETH_4598 ENOG4105SCY DNAK suppressor AMETH_4600 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AMETH_4610 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AMETH_4611 ENOG4105KBH arsR family transcriptional regulator AMETH_4612 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AMETH_4614 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AMETH_4615 ENOG4105FBW Monooxygenase AMETH_4618 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_4620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AMETH_4621 ENOG4105ETX regulatoR AMETH_4624 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_4630 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_4631 ENOG4106YT9 Enoyl-CoA hydratase AMETH_4634 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AMETH_4635 ENOG4105CHR reductase AMETH_4636 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AMETH_4645 ENOG4108M8W Monooxygenase AMETH_4651 ENOG4105DU0 nucleoside hydrolase AMETH_4652 ENOG4105DJB Major Facilitator Superfamily AMETH_4653 ENOG4105E98 transcriptional regulator DeoR family AMETH_4654 ENOG4105CPQ Dehydrogenase AMETH_4655 ENOG41061GT Aldolase AMETH_4656 ENOG4105CMG Carbohydrate kinase AMETH_4658 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AMETH_4659 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AMETH_4660 ENOG4107R3A FAD linked oxidase domain protein AMETH_4676 ENOG4108J08 Csbd family AMETH_4679 ENOG41080R8 Conserved Protein AMETH_4681 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AMETH_4682 ENOG4108Z0R Transferase AMETH_4683 ENOG41073TP transcriptional regulator AMETH_4684 ENOG4107XBN GntR Family Transcriptional Regulator AMETH_4685 ENOG4108JIK carboxylase AMETH_4689 ENOG4105C26 Dehydrogenase AMETH_4690 ENOG4105E39 Enoyl-CoA hydratase AMETH_4691 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_4693 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AMETH_4706 ENOG4105CNU cell division protein FtsK AMETH_4713 ENOG4105CFQ glutamine synthetase AMETH_4720 ENOG41080HT Transcriptional regulator, arsr family AMETH_4723 ENOG4105C8Y Acetylornithine aminotransferase AMETH_4725 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AMETH_4731 ENOG4105DEN Luciferase family AMETH_4732 ENOG4105DQE DNA ligase AMETH_4734 ENOG4105D9P serine threonine protein kinase AMETH_4736 ENOG4105E0X reductase AMETH_4740 ENOG4105E18 UPF0276 protein AMETH_4742 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F AMETH_4743 ENOG4107JTW chlorite dismutase AMETH_4745 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AMETH_4747 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_4749 ENOG4105CHU acetyl-coa acetyltransferase AMETH_4750 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AMETH_4752 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AMETH_4753 ENOG4105ES4 Nitrilase AMETH_4756 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_4757 ENOG4108V8F Transcriptional regulator, MarR family AMETH_4758 ENOG4105CV8 reductase AMETH_4759 ENOG4106F60 Histidine kinase AMETH_4760 ENOG4105F44 Two component transcriptional regulator, winged helix family AMETH_4767 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AMETH_4771 ENOG4105E33 succinate dehydrogenase AMETH_4773 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AMETH_4774 ENOG4105C0X amino acid AMETH_4775 ENOG4107VEG TrkA-N domain protein AMETH_4782 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AMETH_4789 ENOG4105CUB amino acid AMETH_4796 ENOG4105MDS 4-oxalocrotonate tautomerase AMETH_4798 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AMETH_4801 ENOG4107PP3 Acetylornithine deacetylase AMETH_4803 ENOG4105CH2 amidohydrolase AMETH_4805 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AMETH_4807 ENOG4107GFK fumarate AMETH_4811 ENOG4105CHP RNA polymerase AMETH_4822 ENOG4106A3M Cytochrome p-450 AMETH_4823 ENOG4105F2C Acetyl-CoA acetyltransferase AMETH_4825 ENOG4105DXX methyltransferase AMETH_4827 ENOG4106NZI LysR family Transcriptional regulator AMETH_4829 ENOG4105KVH Transcriptional regulator AMETH_4830 ENOG4105ECR NmrA family AMETH_4833 ENOG4105CH2 amidohydrolase AMETH_4834 ENOG4108KUU Inner membrane metabolite transport protein ydjE AMETH_4835 ENOG4105MXW flavin reductase domain protein, FMN-binding AMETH_4836 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase AMETH_4837 ENOG41088PD hydrolase AMETH_4838 ENOG4108KC1 acyl-Coa dehydrogenase AMETH_4840 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AMETH_4849 ENOG410900P UPF0336 protein AMETH_4850 ENOG4105X7H acyl-CoA dehydrogenase AMETH_4851 ENOG4108RK3 acyl-Coa dehydrogenase AMETH_4854 ENOG4105C0D helicase AMETH_4855 ENOG4105D2B acyl-CoA dehydrogenase AMETH_4856 ENOG4108SGK Tetr family transcriptional regulator AMETH_4860 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AMETH_4861 ENOG410849S phosphocarrier protein (HPr) AMETH_4862 ENOG4105DM4 PTS System AMETH_4863 ENOG4105DM4 PTS System AMETH_4864 ENOG4105DE4 1-phosphofructokinase AMETH_4865 ENOG4105E98 transcriptional regulator DeoR family AMETH_4866 ENOG4105D5P Methylmalonyl-coA mutase AMETH_4869 ENOG4105GWZ Roadblock lc7 family protein AMETH_4872 ENOG4107QN1 sodium solute AMETH_4874 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AMETH_4880 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_4884 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AMETH_4885 ENOG4105C26 Dehydrogenase AMETH_4886 ENOG4107SM8 Adenylate Guanylate cyclase AMETH_4891 ENOG4105C29 acyl-CoA thioesterase AMETH_4893 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_4900 ENOG4105F6E Acyl-transferase AMETH_4903 ENOG4105BZW Glycerate kinase AMETH_4904 ENOG4105C5X domain protein AMETH_4909 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AMETH_4912 ENOG4108NBA ATP-dependent carboxylate-amine ligase (By similarity) AMETH_4913 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AMETH_4920 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AMETH_4924 ENOG4105VEQ Cold shock protein AMETH_4927 ENOG4108XHQ (2Fe-2S)-binding domain protein AMETH_4928 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AMETH_4933 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AMETH_4934 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AMETH_4936 ENOG4105XDV AMETH_4940 ENOG4105DKQ ROK family AMETH_4942 ENOG4105D0U Arsenite-activated ATPase (ArsA) AMETH_4946 ENOG4108IQE Amp-dependent synthetase and ligase AMETH_4960 ENOG4105C26 Dehydrogenase AMETH_4961 ENOG4105CHR reductase AMETH_4963 ENOG4105X7H acyl-CoA dehydrogenase AMETH_4964 ENOG4108KC2 acyl-Coa dehydrogenase AMETH_4965 ENOG4105J5T Amp-dependent synthetase and ligase AMETH_4968 ENOG4105DGU Histone deacetylase AMETH_4970 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AMETH_4971 ENOG4105CMR udp-glucose 4-epimerase AMETH_4975 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AMETH_4981 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AMETH_4982 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AMETH_4984 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AMETH_4986 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AMETH_4989 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AMETH_4991 ENOG4105C99 atpase involved in dna repair AMETH_4995 ENOG4108SC4 )-transporter AMETH_4996 ENOG4106NZI LysR family Transcriptional regulator AMETH_4997 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AMETH_4999 ENOG4105CDA abc transporter atp-binding protein AMETH_5001 ENOG4108Q1T ABC transporter AMETH_5002 ENOG4105DRP amino acid AbC transporter AMETH_5005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AMETH_5007 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component AMETH_5009 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) AMETH_5012 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AMETH_5015 ENOG4105C01 Dihydroxy-acid dehydratase AMETH_5016 ENOG4108UHU Aldolase AMETH_5018 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AMETH_5021 ENOG4105KC9 Modulates RecA activity (By similarity) AMETH_5022 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AMETH_5025 ENOG4108KBA Acts as a chaperone (By similarity) AMETH_5026 ENOG4107QRT dEAD DEAH box helicase AMETH_5027 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AMETH_5037 ENOG4108RNG Permease of the drug metabolite transporter AMETH_5040 ENOG4105DHU Bile acid AMETH_5041 ENOG4108M0I Transcriptional regulator AMETH_5044 ENOG4108UMN azlc family AMETH_5045 ENOG4108IMY Transcriptional regulator AMETH_5048 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) AMETH_5053 ENOG4107S4F acyltransferase, ws dgat mgat AMETH_5055 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase AMETH_5060 ENOG4105CBC glutamate synthase AMETH_5062 ENOG4105EHG Permease protein AMETH_5063 ENOG4105E0A ABC, transporter AMETH_5066 ENOG4107V6M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AMETH_5070 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AMETH_5071 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AMETH_5072 ENOG4105DK0 Indole-3-glycerol phosphate synthase AMETH_5074 ENOG4105CRQ synthase (Component I) AMETH_5076 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AMETH_5077 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AMETH_5080 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AMETH_5081 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AMETH_5086 ENOG4108Z4X TRANSCRIPTIONal AMETH_5088 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) AMETH_5090 ENOG4108IG5 Transcriptional regulator AMETH_5091 ENOG4105EYF MMPL domain protein AMETH_5093 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AMETH_5094 ENOG4105CIH Imidazole acetol-phosphate transaminase AMETH_5095 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AMETH_5097 ENOG4108S01 response regulator AMETH_5101 ENOG4108XG2 Histidine kinase AMETH_5103 ENOG4108IYU L-aspartate oxidase AMETH_5104 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AMETH_5109 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AMETH_5110 ENOG4105CHH sulfate transporter AMETH_5111 ENOG4105VUF Transcriptional regulator AMETH_5113 ENOG4106A3M Cytochrome p-450 AMETH_5116 ENOG4105JNK Glycosyl transferase (Group 1 AMETH_5122 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AMETH_5124 ENOG4107UDY cytochrome C AMETH_5125 ENOG4105CCU oxidase (Subunit III) AMETH_5128 ENOG4107S1N anthranilate phosphoribosyltransferase AMETH_5129 ENOG4108ZRS Part of cytochrome c oxidase, its function is AMETH_5130 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AMETH_5136 ENOG4105CPC Aldo Keto reductase AMETH_5137 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AMETH_5138 ENOG4105CM2 brancheD-chain amino acid aminotransferase AMETH_5140 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AMETH_5145 ENOG4105ECP epimerase AMETH_5147 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AMETH_5152 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AMETH_5154 ENOG4106N3A copper homeostasis protein cutc AMETH_5156 ENOG4105D78 K07001 NTE family protein AMETH_5158 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AMETH_5161 ENOG4105C0B DNA polymerase III (alpha subunit) AMETH_5162 ENOG4108IND Tetr family transcriptional regulator AMETH_5163 ENOG4105CHR reductase AMETH_5173 ENOG4108KD5 ADP-ribosylation crystallin J1 AMETH_5177 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AMETH_5181 ENOG4105DAA L-lactate AMETH_5184 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AMETH_5185 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AMETH_5186 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AMETH_5192 ENOG4107QN2 dihydrolipoyl dehydrogenase AMETH_5193 ENOG4105RFA Lsr2-like protein AMETH_5194 ENOG4105CPU Monooxygenase AMETH_5195 ENOG4105CPU Monooxygenase AMETH_5199 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AMETH_5201 ENOG41069M3 Transcriptional regulator AMETH_5205 ENOG4105FDF Could be involved in DNA repair (By similarity) AMETH_5209 ENOG41073TP transcriptional regulator AMETH_5210 ENOG4105C7K acetolactate synthase AMETH_5211 ENOG4105KK4 UPF0060 membrane protein AMETH_5213 ENOG4105C29 acyl-CoA thioesterase AMETH_5221 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AMETH_5222 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AMETH_5223 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AMETH_5224 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AMETH_5225 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AMETH_5226 ENOG4105DXM phenylacetic acid degradation protein AMETH_5230 ENOG4108IG5 Transcriptional regulator AMETH_5231 ENOG4105EQ0 Major Facilitator superfamily AMETH_5233 ENOG4105E0Y RtcB Protein AMETH_5234 ENOG4105EW9 transcriptional regulator AsnC family AMETH_5240 ENOG4105FBW Monooxygenase AMETH_5241 ENOG4107HP6 Transcriptional regulator AMETH_5250 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AMETH_5251 ENOG4105T38 integral membrane protein AMETH_5252 ENOG4105DQE DNA ligase AMETH_5253 ENOG4107SM8 Adenylate Guanylate cyclase AMETH_5254 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AMETH_5256 ENOG4105DGI Alkaline phosphatase AMETH_5257 ENOG4105CHP RNA polymerase AMETH_5262 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AMETH_5270 ENOG4107SCK Monooxygenase AMETH_5272 ENOG4105MSB protein, conserved in bacteria AMETH_5278 ENOG41067TZ transcriptional regulator, MarR family AMETH_5280 ENOG4105CSH Transporter AMETH_5284 ENOG4105WN5 stage II sporulation protein AMETH_5292 ENOG41080E2 ribosomal-protein-alanine acetyltransferase AMETH_5296 ENOG4105D6N CoA-transferase, subunit a AMETH_5297 ENOG4107HP6 Transcriptional regulator AMETH_5298 ENOG4105H3G oxidoreductase AMETH_5299 ENOG4108Q9V regulatoR AMETH_5302 ENOG4105NI3 Protein of unknown function (DUF3237) AMETH_5306 ENOG4108HRK Histidine kinase AMETH_5307 ENOG4108VAC response regulator AMETH_5311 ENOG4107QN1 sodium solute AMETH_5314 ENOG4105C7W Xanthine dehydrogenase AMETH_5315 ENOG4105C7W Xanthine dehydrogenase AMETH_5316 ENOG4105I82 acetyl xylan esterase AMETH_5317 ENOG41073TP transcriptional regulator AMETH_5318 ENOG4105DEF Extracellular solute-binding protein, family 5 AMETH_5322 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AMETH_5324 ENOG4108478 ec 3.2.1.18 AMETH_5325 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) AMETH_5327 ENOG4105KVH Transcriptional regulator AMETH_5330 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AMETH_5334 ENOG41060NJ transcriptional regulator AMETH_5338 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AMETH_5348 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_5350 ENOG4105CQ7 ATP-dependent helicase AMETH_5351 ENOG4105DMF Dehydrogenase AMETH_5354 ENOG4107S91 Sodium hydrogen exchanger AMETH_5356 ENOG4105C2C drug resistance transporter, Bcr CflA AMETH_5363 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AMETH_5366 ENOG4105E0A ABC, transporter AMETH_5367 ENOG4107ZBN O-methyltransferase AMETH_5369 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AMETH_5370 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AMETH_5372 ENOG4105C26 Dehydrogenase AMETH_5373 ENOG4108Z86 Glutamine amidotransferase AMETH_5376 ENOG4105H3G oxidoreductase AMETH_5383 ENOG4107SCK Monooxygenase AMETH_5385 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_5386 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AMETH_5389 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AMETH_5390 ENOG4107HP6 Transcriptional regulator AMETH_5391 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AMETH_5392 ENOG4105F2Z 3-oxoadipate enol-lactonase AMETH_5393 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AMETH_5394 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha AMETH_5396 ENOG4105CHU acetyl-coa acetyltransferase AMETH_5400 ENOG4105C5I Dehydrogenase AMETH_5407 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AMETH_5410 ENOG4105EG6 Saccharopine dehydrogenase AMETH_5420 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AMETH_5421 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AMETH_5422 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AMETH_5424 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_5426 ENOG4108IV0 ABC, transporter AMETH_5427 ENOG4105C0Z ABC transporter AMETH_5428 ENOG4105C32 Amino acid ABC transporter (Permease) AMETH_5429 ENOG4105C32 Amino acid ABC transporter (Permease) AMETH_5434 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AMETH_5440 ENOG4105E8R UPF0173 metal-dependent hydrolase AMETH_5441 ENOG4105CBC glutamate synthase AMETH_5446 ENOG4105E98 transcriptional regulator DeoR family AMETH_5447 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AMETH_5448 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AMETH_5449 ENOG4108YZT Adenosylcobinamide kinase AMETH_5452 ENOG4105F27 Major Facilitator AMETH_5455 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AMETH_5458 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase AMETH_5460 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) AMETH_5462 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase AMETH_5463 ENOG4105J1Z Arabinosyltransferase AMETH_5465 ENOG41081F0 Precorrin-8x methylmutase AMETH_5466 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AMETH_5469 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AMETH_5471 ENOG4105XEA Tetr family transcriptional regulator AMETH_5474 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_5481 ENOG4107QX3 carboxylase AMETH_5489 ENOG4105VZ8 Transcriptional regulator AMETH_5490 ENOG4105CTK cobaltochelatase, cobn subunit AMETH_5491 ENOG4105E7W lamb ycsf family protein AMETH_5497 ENOG4105KZM cytoplasmic protein AMETH_5498 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AMETH_5503 ENOG4105BZM domain protein AMETH_5505 ENOG4105F0K SARP family transcriptional regulator AMETH_5510 ENOG4108RYK Nad-dependent epimerase dehydratase AMETH_5512 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AMETH_5513 ENOG4105CQB FAD linked oxidase domain protein AMETH_5517 ENOG4105D9P serine threonine protein kinase AMETH_5521 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_5523 ENOG4105DKW ABC transporter AMETH_5526 ENOG4105CSH Transporter AMETH_5530 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AMETH_5531 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AMETH_5533 ENOG41067TZ transcriptional regulator, MarR family AMETH_5536 ENOG4105CHR reductase AMETH_5537 ENOG4107RSM transcriptional regulator AMETH_5538 ENOG4105EYF MMPL domain protein AMETH_5541 ENOG4105C2J ABC transporter AMETH_5543 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AMETH_5546 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AMETH_5548 ENOG4105CHU acetyl-coa acetyltransferase AMETH_5555 ENOG4108QER Adenylate cyclase AMETH_5556 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AMETH_5561 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AMETH_5564 ENOG4108QZR synthase AMETH_5569 ENOG4105D9G High-affinity AMETH_5572 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_5576 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AMETH_5579 ENOG4105C26 Dehydrogenase AMETH_5581 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_5584 ENOG4108D32 Methyltransferase AMETH_5588 ENOG41069M3 Transcriptional regulator AMETH_5592 ENOG410602S Transferase AMETH_5593 ENOG4105BZU Histidine kinase AMETH_5597 ENOG4107MMM Anti-sigma-factor antagonist AMETH_5598 ENOG4105FUA antagonist AMETH_5599 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase AMETH_5616 ENOG4105XYF acetyltransferase AMETH_5618 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AMETH_5628 ENOG4108IG5 Transcriptional regulator AMETH_5636 ENOG4105CG3 alpha amylase, catalytic region AMETH_5640 ENOG4105C9U ATP-dependent DNA helicase RecQ AMETH_5642 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AMETH_5649 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AMETH_5651 ENOG4105CHR reductase AMETH_5652 ENOG4107Y80 Major Facilitator superfamily AMETH_5653 ENOG4105BZU Histidine kinase AMETH_5655 ENOG4107TB5 TRANSCRIPTIONal AMETH_5657 ENOG4107RN6 Monooxygenase AMETH_5658 ENOG4108IG5 Transcriptional regulator AMETH_5668 ENOG4105RNG membrane AMETH_5669 ENOG4105K6V RNA polymerase AMETH_5671 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AMETH_5672 ENOG4108W9H Tetr family transcriptional regulator AMETH_5673 ENOG4105CSH Transporter AMETH_5674 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AMETH_5682 ENOG4105DVC DnaJ domain protein AMETH_5684 ENOG4105CFF transcriptional regulator AMETH_5686 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) AMETH_5695 ENOG4105CPQ Dehydrogenase AMETH_5698 ENOG4108KPJ rna polymerase sigma factor AMETH_5699 ENOG4105C7K acetolactate synthase AMETH_5700 ENOG4105CHF Glutathione S-transferase AMETH_5703 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AMETH_5709 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AMETH_5710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AMETH_5712 ENOG4108JPW Aminotransferase AMETH_5716 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AMETH_5717 ENOG4105CHU acetyl-coa acetyltransferase AMETH_5721 ENOG4105C1G acyl-Coa dehydrogenase AMETH_5722 ENOG4105C1G acyl-Coa dehydrogenase AMETH_5723 ENOG4105DNP FAD linked oxidase domain protein AMETH_5727 ENOG4105NPE arsR family transcriptional regulator AMETH_5728 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AMETH_5734 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AMETH_5735 ENOG4105C1G acyl-Coa dehydrogenase AMETH_5737 ENOG4107QX3 carboxylase AMETH_5744 ENOG4105DWV Homoserine O-trans-acetylase AMETH_5747 ENOG4108K8K Transcriptional regulator AMETH_5753 ENOG4105BZ1 (ABC) transporter AMETH_5754 ENOG4105CQB FAD linked oxidase domain protein AMETH_5760 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AMETH_5763 ENOG4105C6K Malic enzyme AMETH_5764 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AMETH_5765 ENOG4108Z0R Transferase AMETH_5769 ENOG4108ZM9 phosphoglycerate mutase AMETH_5773 ENOG4105CBD Diacylglycerol kinase AMETH_5776 ENOG4105WMN AntiSigma factor AMETH_5778 ENOG4108Z66 YbaK ebsC protein AMETH_5780 ENOG4108RAV Conserved protein AMETH_5788 ENOG4105C2N RNA methyltransferase TrmH family group 3 AMETH_5789 ENOG4105PAD Hydrolase AMETH_5791 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AMETH_5792 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea AMETH_5794 ENOG4108T3R lipoprotein lpqB AMETH_5795 ENOG4105BZU Histidine kinase AMETH_5796 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AMETH_5802 ENOG4105CUB amino acid AMETH_5806 ENOG4105EIP mannose-6-phosphate isomerase AMETH_5808 ENOG4105W49 UPF0434 protein AMETH_5809 ENOG4107QKV phosphomannomutase AMETH_5813 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AMETH_5814 ENOG4107XZ0 Peptidase M50 AMETH_5817 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) AMETH_5818 ENOG4105DEF Extracellular solute-binding protein, family 5 AMETH_5822 ENOG4108JQ7 (ABC) transporter AMETH_5823 ENOG4107USK Extracellular solute-binding protein, family 5 AMETH_5827 ENOG4105C31 Tryptophanyl-tRNA synthetase AMETH_5831 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AMETH_5833 ENOG4105CJ1 ABC, transporter AMETH_5835 ENOG4108UCS ABC, transporter AMETH_5836 ENOG4105E0C molybdate abc transporter AMETH_5838 ENOG410842T Pterin carbinolamine dehydratase AMETH_5840 ENOG4105C3G gtp-binding protein AMETH_5843 ENOG4105EYH Exonuclease AMETH_5844 ENOG4107RH8 nuclease SbcCD subunit D AMETH_5847 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AMETH_5849 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AMETH_5851 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AMETH_5854 ENOG4105CAY ferredoxin--nadp reductase AMETH_5855 ENOG4105C9Q fumarate hydratase class II AMETH_5856 ENOG4105CPC Aldo Keto reductase AMETH_5860 ENOG4105D9G High-affinity AMETH_5862 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) AMETH_5864 ENOG4105DQ5 transport system permease protein AMETH_5865 ENOG4105TVJ transport system, permease AMETH_5869 ENOG4108IAB Phoh family AMETH_5876 ENOG4105C7Z Conserved Protein AMETH_5878 ENOG4105T1M mycothiol conjugate amidase mca AMETH_5880 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AMETH_5882 ENOG4105EW9 transcriptional regulator AsnC family AMETH_5883 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AMETH_5885 ENOG4105C7B Threonine dehydratase AMETH_5892 ENOG4105CHU acetyl-coa acetyltransferase AMETH_5898 ENOG4105DHQ Histidine kinase AMETH_5914 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit AMETH_5915 ENOG4105YCI dehydratase medium subunit AMETH_5917 ENOG4108ZFT Dehydratase small subunit AMETH_5918 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AMETH_5919 ENOG4107RR1 TRANSCRIPTIONal AMETH_5920 ENOG4105C26 Dehydrogenase AMETH_5922 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_5928 ENOG4106CY5 excisionase AMETH_5931 ENOG4105VTR Integrase AMETH_5932 ENOG4105CEP NADH dehydrogenase AMETH_5941 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AMETH_5946 ENOG410650H (LipO)protein AMETH_5947 ENOG4105DBE peroxidase AMETH_5948 ENOG4105DXN mazG family AMETH_5952 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_5958 ENOG4105C85 amino acid AMETH_5962 ENOG4105KPY Small multidrug resistance protein AMETH_5966 ENOG4108IG5 Transcriptional regulator AMETH_5969 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AMETH_5973 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AMETH_5974 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AMETH_5976 ENOG4107RCI amp-dependent synthetase and ligase AMETH_5980 ENOG4105C5H ABC transporter AMETH_5981 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AMETH_5982 ENOG4108IG5 Transcriptional regulator AMETH_5984 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AMETH_5985 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AMETH_5986 ENOG4106839 domain protein AMETH_5987 ENOG4105F8V Hydrolase, tatD family AMETH_5988 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AMETH_5999 ENOG4105CRQ synthase (Component I) AMETH_6003 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AMETH_6008 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_6009 ENOG4105E2D ec 3.2.1.52 AMETH_6010 ENOG4105CHR reductase AMETH_6014 ENOG4105C59 p-type ATPase AMETH_6015 ENOG41066UM arsR family transcriptional regulator AMETH_6019 ENOG4105CIR epoxide hydrolase AMETH_6025 ENOG4107EDW L-fucose operon activator AMETH_6026 ENOG4105KME endoribonuclease L-psp AMETH_6027 ENOG4105C26 Dehydrogenase AMETH_6029 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AMETH_6030 ENOG4105CUB amino acid AMETH_6032 ENOG4105DVW rieske (2Fe-2S) AMETH_6033 ENOG4105XPP Protein of unknown function (DUF1275) AMETH_6034 ENOG4105CSH Transporter AMETH_6040 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) AMETH_6042 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AMETH_6047 ENOG4105DK2 UPF0207 protein AMETH_6048 ENOG4106A3R peptidase AMETH_6053 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AMETH_6054 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase AMETH_6059 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AMETH_6062 ENOG4105E98 transcriptional regulator DeoR family AMETH_6065 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_6087 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_6090 ENOG4108Q9V regulatoR AMETH_6091 ENOG4105BZU Histidine kinase AMETH_6092 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta AMETH_6093 ENOG4105CAY ferredoxin--nadp reductase AMETH_6094 ENOG4108Z4U Ferredoxin AMETH_6095 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AMETH_6097 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AMETH_6099 ENOG4107RUY (E1 component), alpha subunit AMETH_6100 ENOG4105CPP Dehydrogenase, E1 component AMETH_6101 ENOG4105C7S Dehydrogenase AMETH_6102 ENOG4105ECQ AraC Family Transcriptional Regulator AMETH_6104 ENOG4105VG1 fes assembly suf system protein AMETH_6115 ENOG4108K3Z AraC family transcriptional regulator AMETH_6116 ENOG4105DTQ mandelate racemase muconate lactonizing AMETH_6117 ENOG4105E98 transcriptional regulator DeoR family AMETH_6118 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AMETH_6119 ENOG4105DKQ ROK family AMETH_6123 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase AMETH_6128 ENOG4105DKQ ROK family AMETH_6132 ENOG4105DRS transport system, permease AMETH_6134 ENOG4105BZ7 extracellular solute-binding protein family 1 AMETH_6135 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AMETH_6140 ENOG4105ERH Fumarylacetoacetate hydrolase AMETH_6146 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_6156 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AMETH_6159 ENOG4105GRZ Ycii-related protein AMETH_6160 ENOG4105CHP RNA polymerase AMETH_6162 ENOG4105T1M mycothiol conjugate amidase mca AMETH_6165 ENOG4107SQD Transcriptional regulator, GntR family AMETH_6168 ENOG4105DND Transcriptional regulator AMETH_6170 ENOG4105C8V SAICAR synthetase AMETH_6175 ENOG4107RSM transcriptional regulator AMETH_6176 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AMETH_6178 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) AMETH_6179 ENOG4105C1G acyl-Coa dehydrogenase AMETH_6180 ENOG4107YB1 Trehalose corynomycolyl transferase AMETH_6182 ENOG4105DQ4 alcohol dehydrogenase AMETH_6184 ENOG4105KST dependent repressor AMETH_6190 ENOG4105E39 Enoyl-CoA hydratase AMETH_6191 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_6194 ENOG4105C1G acyl-Coa dehydrogenase AMETH_6197 ENOG4105E4F Isochorismate synthase AMETH_6199 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_6204 ENOG4108IUX (ABC) transporter AMETH_6206 ENOG4105CVP deoxyribo-dipyrimidine photolyase AMETH_6211 ENOG4105C1G acyl-Coa dehydrogenase AMETH_6212 ENOG4105CI2 imidazolone-5-propionate hydrolase AMETH_6213 ENOG4107WI4 Aldose-1-epimerase AMETH_6214 ENOG4105J7D transcriptional regulator AMETH_6222 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AMETH_6223 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AMETH_6224 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AMETH_6225 ENOG4105CQM Urea amidohydrolase subunit alpha AMETH_6226 ENOG4105KI2 Urea amidohydrolase subunit beta AMETH_6227 ENOG4108YZ9 Urea amidohydrolase subunit gamma AMETH_6230 ENOG4105KME endoribonuclease L-psp AMETH_6231 ENOG4105W1N transcriptional regulator AMETH_6233 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AMETH_6237 ENOG4105FCS tRNA rRNA methyltransferase AMETH_6241 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AMETH_6254 ENOG4107TXC Transcriptional regulator AMETH_6292 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_6298 ENOG4107QZI cell division protein FtsK AMETH_6313 ENOG4107TXC Transcriptional regulator AMETH_6351 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_6357 ENOG4107QZI cell division protein FtsK AMETH_6364 ENOG4107SFI Major Facilitator superfamily AMETH_6368 ENOG4105C7N Xanthine uracil vitamin C permease AMETH_6373 ENOG4108N0W Major Facilitator superfamily AMETH_6375 ENOG4105VEQ Cold shock protein AMETH_6376 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AMETH_6378 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta AMETH_6379 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_6380 ENOG4107TIF Phenazine biosynthesis protein, PhzF family AMETH_6381 ENOG410901E Membrane AMETH_6384 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AMETH_6391 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AMETH_6397 ENOG4108K2B transcriptional regulator AMETH_6402 ENOG4105GWZ Roadblock lc7 family protein AMETH_6405 ENOG4105GWZ Roadblock lc7 family protein AMETH_6407 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AMETH_6408 ENOG4105EAD ABC transporter AMETH_6412 ENOG4105CFI type iii restriction protein res subunit AMETH_6416 ENOG4107R7Y intracellular protease Pfpi family AMETH_6418 ENOG4105CPQ Dehydrogenase AMETH_6419 ENOG4107TCW O-succinylbenzoate synthase AMETH_6422 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AMETH_6424 ENOG4105VEQ Cold shock protein AMETH_6428 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme AMETH_6429 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AMETH_6438 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AMETH_6439 ENOG4105C0H protease AMETH_6445 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AMETH_6449 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AMETH_6451 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AMETH_6452 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AMETH_6454 ENOG4105FDP GntR family transcriptional regulator AMETH_6455 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AMETH_6456 ENOG4105RD7 BadF BadG BcrA BcrD AMETH_6458 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AMETH_6462 ENOG4105EV8 ectoine hydroxylase AMETH_6463 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AMETH_6465 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase AMETH_6470 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AMETH_6471 ENOG4108QIU Dehydrogenase AMETH_6473 ENOG4105FBA Phospholipase Carboxylesterase AMETH_6474 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AMETH_6481 ENOG4105C01 Dihydroxy-acid dehydratase AMETH_6486 ENOG4105EM7 Selenocysteine-specific translation elongation factor AMETH_6487 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AMETH_6488 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) AMETH_6490 ENOG4105K4P CoA-binding domain protein AMETH_6493 ENOG4105CSH Transporter AMETH_6504 ENOG4107T65 Integrase AMETH_6505 ENOG4107T65 Integrase AMETH_6510 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AMETH_6511 ENOG41062GB lipoprotein lpqE AMETH_6512 ENOG4108VJ1 Transcriptional regulator (CarD family AMETH_6513 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AMETH_6514 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AMETH_6515 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AMETH_6516 ENOG4105C8N cysteinyl-tRNA synthetase AMETH_6518 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AMETH_6521 ENOG4107W7X Aldolase AMETH_6523 ENOG4108M3J Dehydrogenase AMETH_6524 ENOG4107YVI ribose 5-phosphate isomerase AMETH_6525 ENOG4105CMT Dihydroxyacetone kinase AMETH_6526 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 AMETH_6527 ENOG4105CVJ phosphoglycerate mutase AMETH_6528 ENOG4105E98 transcriptional regulator DeoR family AMETH_6529 ENOG4105IE8 Alpha-ketoglutarate permease AMETH_6530 ENOG4107S5T Carbohydrate kinase AMETH_6532 ENOG4108UH6 UPF0754 membrane protein AMETH_6533 ENOG4106MP8 UPF0754 membrane protein AMETH_6535 ENOG4105CC5 ABC transporter AMETH_6536 ENOG4105FDK ABC transporter AMETH_6540 ENOG4105CEN a g-specific adenine glycosylase AMETH_6541 ENOG4105CPC Aldo Keto reductase AMETH_6543 ENOG4105EBM Alpha Beta Hydrolase Fold protein AMETH_6544 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AMETH_6546 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AMETH_6548 ENOG4105CHR reductase AMETH_6549 ENOG4108W5M transcriptional regulator AMETH_6554 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AMETH_6555 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AMETH_6561 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AMETH_6562 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AMETH_6563 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AMETH_6568 ENOG4105W1Y Transcriptional regulator AMETH_6572 ENOG4105EUJ GTP cyclohydrolase i AMETH_6573 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AMETH_6580 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AMETH_6583 ENOG4105F0N pyrophosphate phospho-hydrolase AMETH_6584 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AMETH_6590 ENOG4105C6E dna polymerase iii AMETH_6591 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AMETH_6594 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AMETH_6597 ENOG4107TXC Transcriptional regulator AMETH_6599 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for AMETH_6600 ENOG4108I5C dEAD DEAH box helicase AMETH_6610 ENOG4105D17 glycoside hydrolase, family 3 domain protein AMETH_6611 ENOG4105EHZ conserved protein UCP016719 AMETH_6612 ENOG4107S1E Beta-lactamase AMETH_6613 ENOG4106KNT transcriptional regulator AMETH_6614 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AMETH_6616 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AMETH_6617 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AMETH_6622 ENOG4105CSH Transporter AMETH_6624 ENOG4105CHP RNA polymerase AMETH_6628 ENOG4105DUX Transporter AMETH_6629 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AMETH_6631 ENOG4105D74 hydrolase AMETH_6639 ENOG4105EMU Dehydrogenase AMETH_6649 ENOG4105BZ4 penicillin-binding protein AMETH_6650 ENOG4105DIN metallophosphoesterase AMETH_6653 ENOG4105CVK Glutamate decarboxylase AMETH_6654 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction AMETH_6655 ENOG4108ZHJ Organic hydroperoxide resistance protein AMETH_6661 ENOG4105CH6 catalase AMETH_6664 ENOG4105D5T phosphonate abc transporter AMETH_6665 ENOG4107S5I aldo keto reductase AMETH_6669 ENOG4105CFH Aspartokinase AMETH_6675 ENOG4106NZI LysR family Transcriptional regulator AMETH_6676 ENOG4108594 Permease of the drug metabolite transporter AMETH_6678 ENOG4108JQ7 (ABC) transporter AMETH_6679 ENOG4105C3U ABC transporter AMETH_6680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AMETH_6681 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AMETH_6682 ENOG4105DEF Extracellular solute-binding protein, family 5 AMETH_6684 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AMETH_6685 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AMETH_6686 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase AMETH_6689 ENOG4105EDW glycosyl transferase, family 39 AMETH_6691 ENOG4105BZU Histidine kinase AMETH_6692 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AMETH_6700 ENOG4105VEQ Cold shock protein AMETH_6704 ENOG4105CSH Transporter AMETH_6706 ENOG4107Q25 Serine Threonine protein kinase AMETH_6707 ENOG4105CT1 (ABC) transporter AMETH_6710 ENOG4105C7K acetolactate synthase AMETH_6721 ENOG4105CSH Transporter AMETH_6732 ENOG4105CUC YeeE YedE family protein AMETH_6735 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AMETH_6737 ENOG41083YR Protein CrcB homolog AMETH_6743 ENOG4105ETE Transcriptional regulator (LacI family AMETH_6759 ENOG4107T65 Integrase AMETH_6761 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AMETH_6762 ENOG4105FDP GntR family transcriptional regulator AMETH_6771 ENOG4105DHP deoxycytidine triphosphate deaminase AMETH_6775 ENOG4105CSU acyl-Coa dehydrogenase AMETH_6776 ENOG4108SGK Tetr family transcriptional regulator AMETH_6779 ENOG4105DF6 Fe-S oxidoreductase AMETH_6780 ENOG410814C multidrug resistance protein AMETH_6786 ENOG4105CFG Acts as a chaperone (By similarity) AMETH_6787 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AMETH_6788 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AMETH_6789 ENOG4105KNI merR family transcriptional Regulator AMETH_6793 ENOG4105C0R drug resistance transporter emrb qaca subfamily AMETH_6796 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AMETH_6798 ENOG4105EMU Dehydrogenase AMETH_6803 ENOG4105EJ2 Transcriptional regulator AMETH_6804 ENOG4107EFR Flavocytochrome c AMETH_6805 ENOG4107RNU major facilitator superfamily MFS_1 AMETH_6806 ENOG4108W5M transcriptional regulator AMETH_6810 ENOG4105C2N RNA methyltransferase TrmH family group 3 AMETH_6811 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AMETH_6813 ENOG4105ETE Transcriptional regulator (LacI family AMETH_6814 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator AMETH_6815 ENOG4105CNN ABC, transporter AMETH_6816 ENOG4105C2J ABC transporter AMETH_6818 ENOG4107Z1W Fructose transport system kinase AMETH_6819 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AMETH_6821 ENOG4105CEY Amp-dependent synthetase and ligase AMETH_6822 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN AMETH_6823 ENOG4108YYC ycei family AMETH_6825 ENOG4105FS7 Transcriptional regulator AMETH_6826 ENOG4105CQB FAD linked oxidase domain protein AMETH_6828 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN AMETH_6830 ENOG4105CE4 GlcNAc 6-P deacetylase AMETH_6834 ENOG4107FW0 short-chain dehydrogenase reductase AMETH_6835 ENOG4105CPC Aldo Keto reductase AMETH_6846 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AMETH_6850 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AMETH_6851 ENOG4105EEQ Na H antiporter AMETH_6852 ENOG4105C0R drug resistance transporter emrb qaca subfamily AMETH_6853 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AMETH_6860 ENOG4108FKH Transglycosylase SLT domain AMETH_6861 ENOG4105CHM Aminotransferase AMETH_6868 ENOG4105C83 adenylosuccinate lyase AMETH_6872 ENOG4107T8T UPF0173 metal-dependent hydrolase AMETH_6881 ENOG410839H phosphoribosylformylglycinamidine synthase AMETH_6882 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AMETH_6883 ENOG4105BZ1 (ABC) transporter AMETH_6884 ENOG4105BZ1 (ABC) transporter AMETH_6885 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii AMETH_6899 ENOG4105CXB phosphoribosylaminoimidazole synthetase AMETH_6900 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AMETH_6903 ENOG4105D29 Helix-turn-helix type 11 domain protein AMETH_6909 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AMETH_6911 ENOG4107R7A Allophanate hydrolase subunit 2 AMETH_6913 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands AMETH_6915 ENOG4105PKJ carbohydrate binding AMETH_6916 ENOG4105KHC sulfurtransferase AMETH_6920 ENOG4107NHD transcriptional regulator AMETH_6921 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AMETH_6925 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AMETH_6928 ENOG4108UTW Plays a role in the regulation of phosphate uptake AMETH_6929 ENOG4108RCF TRANSCRIPTIONal AMETH_6931 ENOG4105BZU Histidine kinase AMETH_6935 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AMETH_6936 ENOG4108VCA G U mismatch-specific DNA glycosylase AMETH_6938 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_6939 ENOG4105CSU acyl-Coa dehydrogenase AMETH_6942 ENOG4105MHT Transcriptional regulator, ARSR family AMETH_6948 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AMETH_6954 ENOG4105FS0 cytoplasmic membrane protein AMETH_6956 ENOG4108R86 Transcriptional regulator AMETH_6957 ENOG4108F01 MaoC domain protein AMETH_6958 ENOG4105CHR reductase AMETH_6959 ENOG4105CHU acetyl-coa acetyltransferase AMETH_6971 ENOG4105FBW Monooxygenase AMETH_6972 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) AMETH_6975 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AMETH_6977 ENOG4108ZGX Histidine kinase AMETH_6978 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_6979 ENOG4105CHR reductase AMETH_6983 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AMETH_6985 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AMETH_6987 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_6989 ENOG4106PGW Short-chain dehydrogenase reductase Sdr AMETH_6991 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AMETH_7000 ENOG4105DXB Major Facilitator superfamily AMETH_7001 ENOG41067TZ transcriptional regulator, MarR family AMETH_7003 ENOG4105YVS arsR family transcriptional regulator AMETH_7004 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AMETH_7008 ENOG4105BZ4 penicillin-binding protein AMETH_7014 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) AMETH_7016 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AMETH_7017 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AMETH_7026 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AMETH_7028 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AMETH_7035 ENOG41065SU Two-component system sensor kinase AMETH_7036 ENOG4105WH1 Two component transcriptional regulator luxr family AMETH_7038 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AMETH_7040 ENOG4105C8T Leucyl-tRNA synthetase AMETH_7043 ENOG41081DT UPF0301 protein AMETH_7053 ENOG4108XG2 Histidine kinase AMETH_7054 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AMETH_7062 ENOG4105C3M thioredoxin reductase AMETH_7063 ENOG4108E1C hydrolase AMETH_7066 ENOG4105CPF Cell wall formation (By similarity) AMETH_7068 ENOG4107QJE Chromosome Partitioning Protein AMETH_7069 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AMETH_7072 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AMETH_7074 ENOG41084CH 50S ribosomal protein l34