locus-tag	class	description
AMETH_0005	COG0592	DNA-directed DNA polymerase activity
AMETH_0006	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMETH_0007	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMETH_0008	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AMETH_0009	COG0187	DNA topoisomerase II activity
AMETH_0010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMETH_0030	COG0494	nUDIX hydrolase
AMETH_0033	COG2353	YceI-like domain
AMETH_0048	COG0705	Rhomboid family
AMETH_0048	COG0457	Tetratricopeptide repeat
AMETH_0051	COG3764	Sortase (surface protein transpeptidase)
AMETH_0055	COG1136	(ABC) transporter
AMETH_0059	COG0515	serine threonine protein kinase
AMETH_0060	COG0768	penicillin binding
AMETH_0063	COG1716	ATPase activity
AMETH_0064	COG1716	ATPase activity
AMETH_0069	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMETH_0078	COG2226	methyltransferase
AMETH_0079	COG2186	Transcriptional regulator
AMETH_0080	COG0747	negative chemotaxis
AMETH_0084	COG4608	Belongs to the ABC transporter superfamily
AMETH_0085	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_0086	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_0087	COG0154	amidase activity
AMETH_0090	COG2301	Belongs to the HpcH HpaI aldolase family
AMETH_0101	COG2211	Major facilitator Superfamily
AMETH_0107	COG1276	copper resistance
AMETH_0107	COG2372	response to copper ion
AMETH_0110	COG1174	glycine betaine transport
AMETH_0112	COG1174	glycine betaine transport
AMETH_0119	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMETH_0124	COG4585	Histidine kinase
AMETH_0125	COG2197	response regulator
AMETH_0128	COG0438	transferase activity, transferring glycosyl groups
AMETH_0129	COG4106	trans-aconitate 2-methyltransferase activity
AMETH_0137	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_0138	COG0022	dehydrogenase e1 component
AMETH_0140	COG0683	leucine binding
AMETH_0142	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_0143	COG1022	Amp-dependent synthetase and ligase
AMETH_0146	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_0148	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_0149	COG0765	amino acid transport
AMETH_0154	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMETH_0155	COG3275	phosphorelay sensor kinase activity
AMETH_0159	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_0161	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_0162	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMETH_0162	COG0425	Belongs to the sulfur carrier protein TusA family
AMETH_0167	COG1191	sigma factor activity
AMETH_0178	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_0179	COG1309	transcriptional regulator
AMETH_0182	COG1271	oxidase subunit
AMETH_0183	COG1294	oxidase, subunit
AMETH_0184	COG4988	ABC transporter
AMETH_0187	COG1846	Transcriptional regulator
AMETH_0188	COG1289	transmembrane transporter activity
AMETH_0201	COG1072	(Pantothenic acid kinase))
AMETH_0202	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMETH_0204	COG0406	alpha-ribazole phosphatase activity
AMETH_0207	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_0212	COG0754	glutathionylspermidine amidase activity
AMETH_0213	COG3766	membrane
AMETH_0214	COG0596	Alpha beta hydrolase
AMETH_0216	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMETH_0219	COG0579	oxidoreductase
AMETH_0223	COG2372	response to copper ion
AMETH_0223	COG1276	copper resistance
AMETH_0233	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AMETH_0236	COG0561	phosphatase activity
AMETH_0237	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_0240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMETH_0245	COG1216	Glycosyl transferase, family 2
AMETH_0247	COG0277	FAD linked oxidase domain protein
AMETH_0248	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_0250	COG1216	Glycosyl transferase, family 2
AMETH_0256	COG1063	alcohol dehydrogenase
AMETH_0257	COG2234	aminopeptidase activity
AMETH_0273	COG4585	Histidine kinase
AMETH_0274	COG2197	response regulator
AMETH_0277	COG1522	sequence-specific DNA binding
AMETH_0281	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMETH_0287	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMETH_0289	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_0290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMETH_0290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMETH_0296	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_0297	COG2124	cytochrome p450
AMETH_0299	COG0477	Major facilitator Superfamily
AMETH_0300	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_0302	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_0306	COG2814	Major facilitator Superfamily
AMETH_0307	COG1309	transcriptional regulator
AMETH_0308	COG1937	Protein conserved in bacteria
AMETH_0309	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMETH_0312	COG2072	flavoprotein involved in K transport
AMETH_0314	COG0028	Belongs to the TPP enzyme family
AMETH_0315	COG0248	Ppx GppA phosphatase
AMETH_0316	COG0248	Ppx GppA phosphatase
AMETH_0319	COG2723	6-phospho-beta-galactosidase activity
AMETH_0327	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_0328	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_0329	COG1120	ATPase activity
AMETH_0331	COG3559	Exporter of polyketide antibiotics
AMETH_0332	COG1131	(ABC) transporter
AMETH_0345	COG0287	Prephenate dehydrogenase
AMETH_0355	COG1674	ftsk spoiiie
AMETH_0360	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMETH_0364	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMETH_0368	COG2200	EAL domain
AMETH_0369	COG3033	Beta-eliminating lyase
AMETH_0372	COG1472	Belongs to the glycosyl hydrolase 3 family
AMETH_0381	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_0389	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_0393	COG2733	membrane
AMETH_0397	COG1136	(ABC) transporter
AMETH_0400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMETH_0401	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMETH_0406	COG1174	glycine betaine transport
AMETH_0407	COG1174	glycine betaine transport
AMETH_0410	COG2130	NADP-dependent
AMETH_0411	COG0788	formyltetrahydrofolate deformylase activity
AMETH_0418	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMETH_0421	COG0438	transferase activity, transferring glycosyl groups
AMETH_0423	COG0588	phosphoglycerate mutase activity
AMETH_0425	COG3226	Transcriptional regulator
AMETH_0427	COG0667	Aldo Keto reductase
AMETH_0428	COG5002	protein histidine kinase activity
AMETH_0432	COG1082	Xylose isomerase domain protein TIM barrel
AMETH_0433	COG0506	proline dehydrogenase activity
AMETH_0435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMETH_0441	COG0560	Phosphoserine phosphatase
AMETH_0444	COG1595	DNA-templated transcription, initiation
AMETH_0445	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_0448	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMETH_0449	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMETH_0450	COG0181	hydroxymethylbilane synthase activity
AMETH_0451	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMETH_0451	COG1648	precorrin-2 dehydrogenase activity
AMETH_0456	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMETH_0457	COG0406	alpha-ribazole phosphatase activity
AMETH_0461	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMETH_0467	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMETH_0471	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AMETH_0472	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AMETH_0479	COG0438	transferase activity, transferring glycosyl groups
AMETH_0480	COG2226	methyltransferase
AMETH_0484	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMETH_0485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMETH_0486	COG0649	NAD binding
AMETH_0489	COG1034	ATP synthesis coupled electron transport
AMETH_0490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMETH_0491	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMETH_0492	COG0839	Belongs to the complex I subunit 6 family
AMETH_0493	COG0713	ATP synthesis coupled electron transport
AMETH_0496	COG1007	ATP synthesis coupled electron transport
AMETH_0499	COG0142	geranyltranstransferase activity
AMETH_0501	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMETH_0502	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMETH_0502	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMETH_0504	COG1522	sequence-specific DNA binding
AMETH_0505	COG1834	amidinotransferase
AMETH_0507	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMETH_0510	COG4310	Domain of unknown function (DUF2172)
AMETH_0512	COG1216	Glycosyl transferase, family 2
AMETH_0514	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMETH_0515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMETH_0530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMETH_0532	COG0297	glycogen (starch) synthase activity
AMETH_0533	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMETH_0538	COG0367	asparagine synthase
AMETH_0542	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMETH_0543	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_0545	COG0501	Belongs to the peptidase M48B family
AMETH_0546	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AMETH_0547	COG0596	Alpha beta hydrolase
AMETH_0548	COG1309	transcriptional regulator
AMETH_0549	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_0554	COG1666	GTP binding
AMETH_0563	COG1674	ftsk spoiiie
AMETH_0578	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMETH_0584	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMETH_0585	COG0577	efflux transmembrane transporter activity
AMETH_0587	COG4941	Belongs to the sigma-70 factor family
AMETH_0589	COG1793	dna ligase
AMETH_0592	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AMETH_0593	COG1169	isochorismate synthase
AMETH_0594	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_0595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_0596	COG1021	2,3-dihydroxybenzoate-AMP ligase
AMETH_0597	COG0477	Major facilitator Superfamily
AMETH_0601	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMETH_0603	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AMETH_0605	COG0438	transferase activity, transferring glycosyl groups
AMETH_0608	COG2132	Multicopper oxidase
AMETH_0609	COG2197	response regulator
AMETH_0612	COG4585	Histidine kinase
AMETH_0613	COG0586	Pfam SNARE associated Golgi protein
AMETH_0614	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMETH_0615	COG5001	Diguanylate cyclase
AMETH_0616	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMETH_0617	COG2030	dehydratase
AMETH_0621	COG2755	lipolytic protein G-D-S-L family
AMETH_0622	COG0436	Aminotransferase
AMETH_0623	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AMETH_0625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMETH_0626	COG0081	regulation of translation
AMETH_0628	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMETH_0629	COG0222	ribosome binding
AMETH_0632	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_0637	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMETH_0642	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMETH_0647	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMETH_0648	COG0049	tRNA binding
AMETH_0649	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMETH_0652	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMETH_0653	COG0088	Forms part of the polypeptide exit tunnel
AMETH_0654	COG0089	rRNA binding
AMETH_0655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMETH_0656	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMETH_0657	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMETH_0658	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMETH_0659	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMETH_0660	COG0255	Belongs to the universal ribosomal protein uL29 family
AMETH_0661	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMETH_0662	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMETH_0663	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMETH_0664	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMETH_0666	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMETH_0667	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMETH_0669	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMETH_0670	COG1841	ribosomal large subunit assembly
AMETH_0675	COG0563	adenylate kinase activity
AMETH_0677	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMETH_0678	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMETH_0679	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMETH_0681	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMETH_0682	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMETH_0683	COG0202	RNA polymerase activity
AMETH_0684	COG0203	ribosomal protein L17
AMETH_0685	COG0101	tRNA pseudouridine synthase activity
AMETH_0689	COG3266	domain, Protein
AMETH_0690	COG1404	Belongs to the peptidase S8 family
AMETH_0692	COG1674	ftsk spoiiie
AMETH_0693	COG0443	Heat shock 70 kDa protein
AMETH_0698	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMETH_0700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMETH_0705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_0708	COG1175	transmembrane transport
AMETH_0709	COG0395	ABC-type sugar transport system, permease component
AMETH_0710	COG1063	alcohol dehydrogenase
AMETH_0711	COG1349	DNA-binding transcription factor activity
AMETH_0712	COG1070	Carbohydrate kinase
AMETH_0713	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMETH_0715	COG0802	atpase or kinase
AMETH_0717	COG0825	malonyl-CoA metabolic process
AMETH_0717	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMETH_0718	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_0720	COG2186	Transcriptional regulator
AMETH_0722	COG0456	acetyltransferase
AMETH_0723	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMETH_0725	COG1733	regulation of RNA biosynthetic process
AMETH_0727	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMETH_0728	COG0459	protein refolding
AMETH_0729	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_0730	COG1309	transcriptional regulator
AMETH_0739	COG0516	GMP reductase activity
AMETH_0746	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_0748	COG0519	Catalyzes the synthesis of GMP from XMP
AMETH_0748	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMETH_0754	COG0583	DNA-binding transcription factor activity
AMETH_0764	COG0739	heme binding
AMETH_0766	COG0045	succinate-CoA ligase (ADP-forming) activity
AMETH_0771	COG0138	bifunctional purine biosynthesis protein purh
AMETH_0772	COG0384	phenazine biosynthesis protein PhzF
AMETH_0777	COG0587	DNA-directed DNA polymerase activity
AMETH_0778	COG2816	NAD+ diphosphatase activity
AMETH_0783	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMETH_0785	COG2814	Major facilitator Superfamily
AMETH_0797	COG1234	tRNA 3'-trailer cleavage
AMETH_0798	COG0708	Exodeoxyribonuclease III
AMETH_0804	COG0180	Tryptophanyl-tRNA synthetase
AMETH_0805	COG1295	ribonuclease BN
AMETH_0809	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMETH_0812	COG2009	succinate dehydrogenase
AMETH_0820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMETH_0821	COG2271	Major facilitator Superfamily
AMETH_0827	COG2124	cytochrome p450
AMETH_0829	COG1063	alcohol dehydrogenase
AMETH_0832	COG0395	ABC-type sugar transport system, permease component
AMETH_0834	COG2124	cytochrome p450
AMETH_0837	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_0838	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_0839	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMETH_0845	COG0667	Aldo Keto reductase
AMETH_0848	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMETH_0850	COG0515	serine threonine protein kinase
AMETH_0855	COG1473	amidohydrolase
AMETH_0855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMETH_0861	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_0862	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMETH_0863	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMETH_0868	COG4770	biotin carboxylase activity
AMETH_0870	COG1301	dicarboxylic acid transport
AMETH_0871	COG0424	maF-like protein
AMETH_0875	COG1802	Transcriptional regulator
AMETH_0878	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_0881	COG0640	Transcriptional regulator
AMETH_0882	COG3467	pyridoxamine 5'-phosphate
AMETH_0886	COG1733	regulation of RNA biosynthetic process
AMETH_0888	COG1388	LysM domain
AMETH_0888	COG3103	Sh3 type 3 domain protein
AMETH_0888	COG0791	NLP P60 protein
AMETH_0897	COG0483	inositol monophosphate 1-phosphatase activity
AMETH_0898	COG0745	RESPONSE REGULATOR receiver
AMETH_0899	COG2205	protein histidine kinase activity
AMETH_0908	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_0909	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_0912	COG2259	Doxx family
AMETH_0914	COG1316	TRANSCRIPTIONal
AMETH_0915	COG1316	TRANSCRIPTIONal
AMETH_0919	COG4221	oxidoreductase activity
AMETH_0920	COG0438	transferase activity, transferring glycosyl groups
AMETH_0923	COG0438	transferase activity, transferring glycosyl groups
AMETH_0929	COG1725	Transcriptional regulator
AMETH_0934	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMETH_0941	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_0942	COG1611	Belongs to the LOG family
AMETH_0945	COG0463	Glycosyl transferase, family 2
AMETH_0948	COG2818	Glycosylase
AMETH_0949	COG1024	Enoyl-CoA hydratase
AMETH_0951	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMETH_0952	COG0583	DNA-binding transcription factor activity
AMETH_0956	COG4122	O-methyltransferase activity
AMETH_0958	COG5662	AntiSigma factor
AMETH_0959	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMETH_0960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMETH_0963	COG2239	Acts as a magnesium transporter
AMETH_0965	COG0330	HflC and HflK could
AMETH_0966	COG1960	acyl-CoA dehydrogenase activity
AMETH_0980	COG0598	Magnesium transport protein CorA
AMETH_0983	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_0987	COG0613	PHP domain protein
AMETH_0988	COG2095	MarC family integral membrane protein
AMETH_0993	COG1704	LemA family
AMETH_0994	COG0501	Belongs to the peptidase M48B family
AMETH_0997	COG0513	Belongs to the DEAD box helicase family
AMETH_1003	COG2267	carboxylic ester hydrolase activity
AMETH_1009	COG0243	molybdopterin cofactor binding
AMETH_1010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_1012	COG2146	nitrite reductase [NAD(P)H] activity
AMETH_1012	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_1013	COG2146	nitrite reductase [NAD(P)H] activity
AMETH_1016	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_1021	COG2378	regulation of single-species biofilm formation
AMETH_1025	COG1074	ATP-dependent DNA helicase activity
AMETH_1027	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMETH_1033	COG0714	Associated with various cellular activities
AMETH_1040	COG1309	transcriptional regulator
AMETH_1043	COG0612	Peptidase, M16
AMETH_1049	COG3265	gluconokinase activity
AMETH_1051	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMETH_1055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMETH_1057	COG0406	alpha-ribazole phosphatase activity
AMETH_1057	COG0328	RNA-DNA hybrid ribonuclease activity
AMETH_1058	COG2207	Transcriptional regulator
AMETH_1059	COG0667	Aldo Keto reductase
AMETH_1075	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AMETH_1077	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AMETH_1080	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_1081	COG3842	ATPase activity
AMETH_1082	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMETH_1083	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMETH_1084	COG1177	transmembrane transport
AMETH_1085	COG1968	undecaprenyl-diphosphatase activity
AMETH_1086	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMETH_1091	COG2318	DinB family
AMETH_1092	COG0653	protein targeting
AMETH_1096	COG4977	sequence-specific DNA binding
AMETH_1098	COG0174	glutamine synthetase
AMETH_1100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMETH_1102	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMETH_1103	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_1108	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMETH_1109	COG2080	2 iron, 2 sulfur cluster binding
AMETH_1110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_1111	COG3835	regulator
AMETH_1114	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMETH_1118	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_1122	COG0174	glutamine synthetase
AMETH_1131	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMETH_1135	COG3480	Lon protease (S16) C-terminal proteolytic domain
AMETH_1137	COG1615	UPF0182 protein
AMETH_1139	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMETH_1140	COG2884	Cell division ATP-binding protein ftsE
AMETH_1141	COG2177	Part of the ABC transporter FtsEX involved in
AMETH_1142	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMETH_1148	COG2197	response regulator
AMETH_1152	COG2986	histidine ammonia-lyase
AMETH_1153	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMETH_1154	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_1156	COG1228	amidohydrolase
AMETH_1163	COG4585	Histidine kinase
AMETH_1166	COG1131	(ABC) transporter
AMETH_1168	COG1643	Atp-dependent helicase
AMETH_1171	COG1960	acyl-CoA dehydrogenase activity
AMETH_1174	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_1177	COG0183	Belongs to the thiolase family
AMETH_1179	COG1309	transcriptional regulator
AMETH_1181	COG0145	ligase activity
AMETH_1184	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_1185	COG1414	Transcriptional regulator
AMETH_1187	COG0492	ferredoxin-NADP+ reductase activity
AMETH_1188	COG1960	acyl-CoA dehydrogenase activity
AMETH_1193	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_1195	COG1960	acyl-CoA dehydrogenase activity
AMETH_1198	COG3384	dioxygenase
AMETH_1201	COG2124	cytochrome p450
AMETH_1208	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_1209	COG1127	ABC transporter
AMETH_1220	COG0714	Associated with various cellular activities
AMETH_1235	COG1024	Enoyl-CoA hydratase
AMETH_1239	COG1595	DNA-templated transcription, initiation
AMETH_1241	COG4999	Histidine kinase
AMETH_1241	COG3437	response regulator, receiver
AMETH_1241	COG2205	protein histidine kinase activity
AMETH_1241	COG3850	Histidine kinase
AMETH_1242	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_1243	COG0583	DNA-binding transcription factor activity
AMETH_1246	COG1119	ATPase activity
AMETH_1247	COG0583	DNA-binding transcription factor activity
AMETH_1249	COG3293	Transposase
AMETH_1253	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMETH_1254	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_1264	COG1216	Glycosyl transferase, family 2
AMETH_1264	COG0438	transferase activity, transferring glycosyl groups
AMETH_1266	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMETH_1267	COG0564	pseudouridine synthase activity
AMETH_1270	COG0187	DNA topoisomerase II activity
AMETH_1271	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMETH_1273	COG2208	phosphoserine phosphatase activity
AMETH_1274	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_1275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_1277	COG0583	DNA-binding transcription factor activity
AMETH_1278	COG3293	Transposase
AMETH_1279	COG0129	dihydroxy-acid dehydratase activity
AMETH_1284	COG4336	lyase activity
AMETH_1294	COG3537	Alpha-1,2-mannosidase
AMETH_1301	COG2079	MmgE PrpD family protein
AMETH_1303	COG2301	Belongs to the HpcH HpaI aldolase family
AMETH_1304	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_1306	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_1307	COG4214	carbohydrate transport
AMETH_1309	COG0410	ABC transporter
AMETH_1312	COG1053	succinate dehydrogenase
AMETH_1315	COG3285	dna ligase
AMETH_1315	COG1793	dna ligase
AMETH_1318	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_1319	COG1063	alcohol dehydrogenase
AMETH_1321	COG1280	lysine exporter protein (LysE YggA)
AMETH_1326	COG3191	aminopeptidase activity
AMETH_1329	COG1609	Transcriptional regulator
AMETH_1336	COG0018	arginyl-trna synthetase
AMETH_1337	COG0019	diaminopimelate decarboxylase activity
AMETH_1338	COG0460	homoserine dehydrogenase
AMETH_1339	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMETH_1340	COG0083	homoserine kinase activity
AMETH_1343	COG0254	rRNA binding
AMETH_1344	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMETH_1345	COG2267	carboxylic ester hydrolase activity
AMETH_1347	COG2890	protein-(glutamine-N5) methyltransferase activity
AMETH_1349	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMETH_1351	COG0356	it plays a direct role in the translocation of protons across the membrane
AMETH_1352	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMETH_1353	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMETH_1354	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMETH_1355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMETH_1356	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMETH_1357	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMETH_1358	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMETH_1363	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMETH_1365	COG1280	lysine exporter protein (LysE YggA)
AMETH_1368	COG0765	amino acid transport
AMETH_1369	COG0765	amino acid transport
AMETH_1370	COG1126	abc transporter atp-binding protein
AMETH_1371	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_1376	COG1414	Transcriptional regulator
AMETH_1378	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AMETH_1381	COG2814	Major facilitator Superfamily
AMETH_1382	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AMETH_1387	COG2376	Dihydroxyacetone kinase
AMETH_1390	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_1393	COG1309	transcriptional regulator
AMETH_1407	COG1335	isochorismatase
AMETH_1408	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AMETH_1409	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMETH_1411	COG3191	aminopeptidase activity
AMETH_1419	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMETH_1420	COG1234	tRNA 3'-trailer cleavage
AMETH_1423	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMETH_1424	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMETH_1425	COG1984	allophanate hydrolase subunit 2
AMETH_1426	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMETH_1427	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMETH_1434	COG0300	oxidoreductase activity
AMETH_1439	COG1234	tRNA 3'-trailer cleavage
AMETH_1444	COG0110	maltose O-acetyltransferase activity
AMETH_1445	COG0431	NADPH-dependent FMN reductase
AMETH_1455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMETH_1459	COG1307	EDD domain protein, DegV family
AMETH_1461	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMETH_1467	COG0482	sulfurtransferase activity
AMETH_1469	COG2201	protein-glutamate methylesterase activity
AMETH_1481	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_1485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMETH_1489	COG2409	Drug exporters of the RND superfamily
AMETH_1491	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMETH_1492	COG0154	amidase activity
AMETH_1498	COG2259	Doxx family
AMETH_1499	COG0129	dihydroxy-acid dehydratase activity
AMETH_1501	COG1335	isochorismatase
AMETH_1507	COG0440	acetolactate synthase activity
AMETH_1508	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMETH_1511	COG1404	Belongs to the peptidase S8 family
AMETH_1512	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_1513	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_1516	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_1518	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMETH_1526	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMETH_1527	COG0066	3-isopropylmalate dehydratase activity
AMETH_1530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AMETH_1533	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMETH_1540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_1541	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMETH_1547	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMETH_1548	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMETH_1549	COG1461	Dihydroxyacetone kinase
AMETH_1552	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AMETH_1554	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMETH_1555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_1557	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_1558	COG3973	AAA domain
AMETH_1559	COG0742	ribosomal rna small subunit methyltransferase
AMETH_1560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMETH_1564	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMETH_1565	COG0571	ribonuclease III activity
AMETH_1566	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMETH_1567	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AMETH_1570	COG0367	asparagine synthase
AMETH_1572	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMETH_1573	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMETH_1574	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMETH_1578	COG1254	Belongs to the acylphosphatase family
AMETH_1582	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_1583	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMETH_1590	COG1414	Transcriptional regulator
AMETH_1594	COG3835	regulator
AMETH_1598	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_1601	COG0596	Alpha beta hydrolase
AMETH_1602	COG2233	PERMEase
AMETH_1607	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMETH_1608	COG4266	Belongs to the allantoicase family
AMETH_1610	COG1832	CoA-binding protein
AMETH_1618	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMETH_1626	COG0228	four-way junction DNA binding
AMETH_1628	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMETH_1629	COG0336	Belongs to the RNA methyltransferase TrmD family
AMETH_1630	COG0335	large ribosomal subunit rRNA binding
AMETH_1631	COG0681	Belongs to the peptidase S26 family
AMETH_1632	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMETH_1634	COG0792	nuclease activity
AMETH_1635	COG0606	chelatase, subunit chli
AMETH_1638	COG1191	sigma factor activity
AMETH_1640	COG0052	Belongs to the universal ribosomal protein uS2 family
AMETH_1641	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMETH_1642	COG0528	UMP kinase activity
AMETH_1643	COG0233	cytoplasmic translational termination
AMETH_1648	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMETH_1650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMETH_1651	COG0750	zinc metalloprotease
AMETH_1652	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMETH_1658	COG2186	Transcriptional regulator
AMETH_1659	COG2807	transmembrane transport
AMETH_1667	COG1733	regulation of RNA biosynthetic process
AMETH_1668	COG0513	Belongs to the DEAD box helicase family
AMETH_1670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMETH_1671	COG3022	response to hydroperoxide
AMETH_1676	COG0539	negative regulation of cytoplasmic translation
AMETH_1676	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMETH_1676	COG1185	polyribonucleotide nucleotidyltransferase activity
AMETH_1679	COG1609	Transcriptional regulator
AMETH_1685	COG2902	Dehydrogenase
AMETH_1688	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_1690	COG0668	transmembrane transport
AMETH_1694	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AMETH_1696	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_1703	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMETH_1706	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AMETH_1712	COG2186	Transcriptional regulator
AMETH_1718	COG1793	dna ligase
AMETH_1718	COG3285	dna ligase
AMETH_1722	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_1726	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMETH_1727	COG2205	protein histidine kinase activity
AMETH_1731	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_1732	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMETH_1733	COG0740	serine-type endopeptidase activity
AMETH_1734	COG0740	serine-type endopeptidase activity
AMETH_1735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMETH_1739	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMETH_1747	COG2353	YceI-like domain
AMETH_1748	COG0346	lactoylglutathione lyase activity
AMETH_1750	COG0477	Major facilitator Superfamily
AMETH_1753	COG0525	valine-tRNA ligase activity
AMETH_1757	COG2755	lipolytic protein G-D-S-L family
AMETH_1758	COG2188	Transcriptional regulator
AMETH_1759	COG1397	ADP-ribosylglycohydrolase
AMETH_1761	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMETH_1762	COG1960	acyl-CoA dehydrogenase activity
AMETH_1763	COG0154	amidase activity
AMETH_1766	COG0285	dihydrofolate synthase activity
AMETH_1770	COG0105	UTP biosynthetic process
AMETH_1771	COG1414	Transcriptional regulator
AMETH_1772	COG1131	(ABC) transporter
AMETH_1776	COG1530	ribonuclease E activity
AMETH_1776	COG1530	ribonuclease E activity
AMETH_1777	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMETH_1778	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMETH_1779	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMETH_1781	COG0477	Major facilitator Superfamily
AMETH_1782	COG0514	ATP-dependent DNA helicase (RecQ)
AMETH_1783	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMETH_1784	COG0799	negative regulation of ribosome biogenesis
AMETH_1786	COG2755	lipolytic protein G-D-S-L family
AMETH_1787	COG1307	EDD domain protein, DegV family
AMETH_1788	COG1555	photosystem II stabilization
AMETH_1788	COG1596	polysaccharide export
AMETH_1789	COG2333	competence protein COMEC
AMETH_1789	COG0658	competence protein
AMETH_1790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMETH_1792	COG0268	Binds directly to 16S ribosomal RNA
AMETH_1801	COG2070	2-Nitropropane dioxygenase
AMETH_1804	COG1802	Transcriptional regulator
AMETH_1805	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_1806	COG1053	succinate dehydrogenase
AMETH_1807	COG0477	Major facilitator Superfamily
AMETH_1814	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMETH_1816	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AMETH_1817	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_1820	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_1821	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_1823	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_1828	COG1309	transcriptional regulator
AMETH_1829	COG0022	dehydrogenase e1 component
AMETH_1830	COG1063	alcohol dehydrogenase
AMETH_1831	COG1960	acyl-CoA dehydrogenase activity
AMETH_1834	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_1835	COG4191	Histidine kinase
AMETH_1838	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_1839	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_1840	COG1127	ABC transporter
AMETH_1849	COG2197	response regulator
AMETH_1850	COG3384	dioxygenase
AMETH_1856	COG2368	4-hydroxyphenylacetate
AMETH_1857	COG2267	carboxylic ester hydrolase activity
AMETH_1860	COG4638	Rieske (2fe-2S)
AMETH_1865	COG2086	electron transfer activity
AMETH_1871	COG0531	amino acid
AMETH_1874	COG0604	alcohol dehydrogenase
AMETH_1877	COG2732	(Barnase) inhibitor
AMETH_1880	COG1024	Enoyl-CoA hydratase
AMETH_1885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_1886	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMETH_1887	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMETH_1896	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMETH_1916	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMETH_1918	COG1953	Uracil, thiamine, allantoin
AMETH_1921	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMETH_1923	COG1420	regulation of RNA biosynthetic process
AMETH_1924	COG0484	heat shock protein binding
AMETH_1926	COG0537	adenosine 5'-monophosphoramidase activity
AMETH_1928	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMETH_1931	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMETH_1934	COG1381	Involved in DNA repair and RecF pathway recombination
AMETH_1935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMETH_1937	COG0701	Predicted permease
AMETH_1943	COG0423	glycine-tRNA ligase activity
AMETH_1945	COG1396	sequence-specific DNA binding
AMETH_1946	COG1131	(ABC) transporter
AMETH_1948	COG4585	Histidine kinase
AMETH_1949	COG2197	response regulator
AMETH_1958	COG1595	DNA-templated transcription, initiation
AMETH_1959	COG0358	DNA primase activity
AMETH_1961	COG4106	trans-aconitate 2-methyltransferase activity
AMETH_1962	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMETH_1974	COG1116	anion transmembrane transporter activity
AMETH_1979	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_1980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_1988	COG0411	ABC transporter
AMETH_1989	COG0410	ABC transporter
AMETH_1990	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_1991	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_1995	COG3467	pyridoxamine 5'-phosphate
AMETH_1999	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2010	COG0124	histidyl-tRNA synthetase
AMETH_2011	COG0596	Alpha beta hydrolase
AMETH_2012	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_2013	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMETH_2014	COG2080	2 iron, 2 sulfur cluster binding
AMETH_2015	COG1802	Transcriptional regulator
AMETH_2017	COG1454	alcohol dehydrogenase
AMETH_2019	COG0277	FAD linked oxidase domain protein
AMETH_2019	COG0247	lactate metabolic process
AMETH_2022	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_2024	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_2028	COG0183	Belongs to the thiolase family
AMETH_2029	COG1960	acyl-CoA dehydrogenase activity
AMETH_2030	COG1960	acyl-CoA dehydrogenase activity
AMETH_2031	COG1024	Enoyl-CoA hydratase
AMETH_2032	COG1024	Enoyl-CoA hydratase
AMETH_2033	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2034	COG1960	acyl-CoA dehydrogenase activity
AMETH_2039	COG0009	L-threonylcarbamoyladenylate synthase
AMETH_2042	COG4221	oxidoreductase activity
AMETH_2052	COG1024	Enoyl-CoA hydratase
AMETH_2054	COG0406	alpha-ribazole phosphatase activity
AMETH_2062	COG0302	gtp cyclohydrolase
AMETH_2068	COG0523	cobalamin synthesis protein
AMETH_2069	COG4565	transcriptional regulatory protein
AMETH_2070	COG3290	protein histidine kinase activity
AMETH_2075	COG1309	transcriptional regulator
AMETH_2076	COG0791	NLP P60 protein
AMETH_2077	COG1984	allophanate hydrolase subunit 2
AMETH_2078	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMETH_2085	COG1674	ftsk spoiiie
AMETH_2099	COG3629	intracellular signal transduction
AMETH_2099	COG3903	Transcriptional regulator
AMETH_2100	COG3903	Transcriptional regulator
AMETH_2100	COG3629	intracellular signal transduction
AMETH_2101	COG2197	response regulator
AMETH_2102	COG3903	Transcriptional regulator
AMETH_2102	COG3629	intracellular signal transduction
AMETH_2105	COG0671	phosphoesterase, PA-phosphatase related
AMETH_2112	COG1595	DNA-templated transcription, initiation
AMETH_2119	COG2011	ABC-type metal ion transport system permease component
AMETH_2120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMETH_2121	COG1464	Belongs to the NlpA lipoprotein family
AMETH_2127	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMETH_2130	COG3473	Maleate cis-trans isomerase
AMETH_2131	COG1737	Transcriptional regulator
AMETH_2132	COG1609	Transcriptional regulator
AMETH_2133	COG1129	ABC transporter
AMETH_2134	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_2135	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_2139	COG3347	Dehydrogenase
AMETH_2139	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2141	COG1070	Carbohydrate kinase
AMETH_2142	COG0247	lactate metabolic process
AMETH_2143	COG1139	Iron-sulfur cluster binding protein
AMETH_2144	COG1556	Lactate utilization protein
AMETH_2146	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2150	COG0402	S-adenosylhomocysteine deaminase activity
AMETH_2151	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_2156	COG1414	Transcriptional regulator
AMETH_2158	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMETH_2160	COG0789	Transcriptional regulator
AMETH_2161	COG2814	Major facilitator Superfamily
AMETH_2162	COG0477	Major facilitator Superfamily
AMETH_2167	COG0477	Major facilitator Superfamily
AMETH_2170	COG2124	cytochrome p450
AMETH_2174	COG4829	muconolactone delta-isomerase
AMETH_2175	COG3485	protocatechuate 3,4-dioxygenase
AMETH_2176	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_2177	COG0583	DNA-binding transcription factor activity
AMETH_2178	COG4638	Rieske (2fe-2S)
AMETH_2181	COG2814	Major facilitator Superfamily
AMETH_2183	COG3135	benzoate transporter
AMETH_2185	COG1793	dna ligase
AMETH_2185	COG3285	dna ligase
AMETH_2187	COG0702	epimerase
AMETH_2189	COG0515	serine threonine protein kinase
AMETH_2194	COG0673	inositol 2-dehydrogenase activity
AMETH_2197	COG0405	Gamma-glutamyltransferase
AMETH_2206	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMETH_2220	COG0702	epimerase
AMETH_2221	COG0702	epimerase
AMETH_2223	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_2224	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_2226	COG1090	epimerase
AMETH_2228	COG1609	Transcriptional regulator
AMETH_2231	COG0477	Major facilitator Superfamily
AMETH_2234	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_2238	COG1942	4-Oxalocrotonate Tautomerase
AMETH_2239	COG0477	Major facilitator Superfamily
AMETH_2242	COG2376	Dihydroxyacetone kinase
AMETH_2243	COG0698	ribose 5-phosphate isomerase
AMETH_2245	COG3959	Transketolase, thiamine diphosphate binding domain
AMETH_2246	COG3958	Transketolase
AMETH_2247	COG2197	response regulator
AMETH_2248	COG0477	Major facilitator Superfamily
AMETH_2249	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_2250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2251	COG0640	Transcriptional regulator
AMETH_2252	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2257	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2266	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMETH_2268	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_2269	COG2301	Belongs to the HpcH HpaI aldolase family
AMETH_2285	COG0300	oxidoreductase activity
AMETH_2294	COG4104	PAAR repeat-containing protein
AMETH_2294	COG3209	COG3209 Rhs family protein
AMETH_2295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_2298	COG4152	abc transporter atp-binding protein
AMETH_2301	COG0708	Exodeoxyribonuclease III
AMETH_2308	COG1733	regulation of RNA biosynthetic process
AMETH_2310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2312	COG0488	(ABC) transporter
AMETH_2318	COG1595	DNA-templated transcription, initiation
AMETH_2322	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2337	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMETH_2338	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMETH_2346	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2348	COG1408	metallophosphoesterase
AMETH_2352	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMETH_2353	COG1739	Uncharacterized protein family UPF0029
AMETH_2357	COG4221	oxidoreductase activity
AMETH_2358	COG2186	Transcriptional regulator
AMETH_2359	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_2361	COG0145	ligase activity
AMETH_2363	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_2364	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2374	COG1063	alcohol dehydrogenase
AMETH_2375	COG0459	protein refolding
AMETH_2376	COG1024	Enoyl-CoA hydratase
AMETH_2379	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_2380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_2384	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMETH_2385	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_2386	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_2386	COG0022	dehydrogenase e1 component
AMETH_2387	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMETH_2391	COG3732	PTS system glucitol sorbitol-specific
AMETH_2393	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_2394	COG2390	Transcriptional regulator
AMETH_2395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMETH_2401	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMETH_2405	COG0745	RESPONSE REGULATOR receiver
AMETH_2406	COG5002	protein histidine kinase activity
AMETH_2408	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2409	COG3384	dioxygenase
AMETH_2412	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMETH_2413	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_2413	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_2425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2428	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2429	COG0604	alcohol dehydrogenase
AMETH_2430	COG0646	methionine synthase
AMETH_2430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMETH_2431	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_2432	COG0402	S-adenosylhomocysteine deaminase activity
AMETH_2443	COG0779	Required for maturation of 30S ribosomal subunits
AMETH_2446	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMETH_2448	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMETH_2451	COG0300	oxidoreductase activity
AMETH_2456	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMETH_2459	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMETH_2463	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMETH_2464	COG1185	polyribonucleotide nucleotidyltransferase activity
AMETH_2465	COG0612	Peptidase, M16
AMETH_2466	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMETH_2469	COG0667	Aldo Keto reductase
AMETH_2475	COG3214	Protein conserved in bacteria
AMETH_2481	COG2815	serine threonine protein kinase
AMETH_2481	COG0515	serine threonine protein kinase
AMETH_2482	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_2483	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMETH_2488	COG0477	Major facilitator Superfamily
AMETH_2492	COG1674	ftsk spoiiie
AMETH_2494	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AMETH_2495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMETH_2497	COG1546	Belongs to the CinA family
AMETH_2497	COG1058	Belongs to the CinA family
AMETH_2498	COG1396	sequence-specific DNA binding
AMETH_2502	COG0167	dihydroorotate dehydrogenase activity
AMETH_2505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMETH_2510	COG1609	Transcriptional regulator
AMETH_2511	COG1305	Transglutaminase-like
AMETH_2513	COG0714	Associated with various cellular activities
AMETH_2518	COG2001	Belongs to the MraZ family
AMETH_2519	COG0275	rRNA processing
AMETH_2521	COG0768	penicillin binding
AMETH_2522	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMETH_2524	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMETH_2525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMETH_2527	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMETH_2528	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMETH_2529	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMETH_2536	COG1799	cell septum assembly
AMETH_2541	COG2226	methyltransferase
AMETH_2544	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMETH_2546	COG0640	Transcriptional regulator
AMETH_2547	COG3263	regulation of cellular component size
AMETH_2548	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMETH_2549	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMETH_2555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2562	COG0154	amidase activity
AMETH_2565	COG0542	response to heat
AMETH_2569	COG0297	glycogen (starch) synthase activity
AMETH_2570	COG3546	catalase activity
AMETH_2573	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMETH_2574	COG2192	nodulation
AMETH_2575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMETH_2576	COG0859	PFAM glycosyl transferase family 9
AMETH_2577	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMETH_2578	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMETH_2578	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMETH_2580	COG0859	PFAM glycosyl transferase family 9
AMETH_2581	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMETH_2587	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMETH_2597	COG2186	Transcriptional regulator
AMETH_2598	COG3386	PFAM SMP-30 Gluconolaconase
AMETH_2602	COG1316	TRANSCRIPTIONal
AMETH_2607	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMETH_2607	COG0237	dephospho-CoA kinase activity
AMETH_2620	COG1131	(ABC) transporter
AMETH_2622	COG0823	Involved in the tonB-independent uptake of proteins
AMETH_2622	COG1506	peptidase
AMETH_2622	COG4946	Tricorn protease homolog
AMETH_2625	COG1129	ABC transporter
AMETH_2626	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_2627	COG1879	ABC-type sugar transport system periplasmic component
AMETH_2628	COG1609	Transcriptional regulator
AMETH_2629	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
AMETH_2630	COG1070	Carbohydrate kinase
AMETH_2631	COG1285	pathogenesis
AMETH_2637	COG0328	RNA-DNA hybrid ribonuclease activity
AMETH_2639	COG3591	Belongs to the peptidase S1B family
AMETH_2639	COG1864	DNA RNA non-specific endonuclease
AMETH_2645	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_2650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_2657	COG1301	dicarboxylic acid transport
AMETH_2658	COG3290	protein histidine kinase activity
AMETH_2659	COG4565	transcriptional regulatory protein
AMETH_2661	COG2706	6-phosphogluconolactonase activity
AMETH_2662	COG2610	gluconate transmembrane transporter activity
AMETH_2663	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMETH_2666	COG0251	oxidation-reduction process
AMETH_2669	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMETH_2670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMETH_2671	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_2672	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMETH_2673	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMETH_2673	COG0072	phenylalanine-tRNA ligase activity
AMETH_2677	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMETH_2678	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMETH_2679	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMETH_2680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMETH_2681	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMETH_2683	COG0165	Argininosuccinate lyase
AMETH_2685	COG2094	Belongs to the DNA glycosylase MPG family
AMETH_2686	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMETH_2688	COG0647	UMP catabolic process
AMETH_2691	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMETH_2698	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMETH_2699	COG0504	CTP synthase activity
AMETH_2700	COG0494	nUDIX hydrolase
AMETH_2705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMETH_2707	COG0514	ATP-dependent DNA helicase (RecQ)
AMETH_2709	COG0475	glutathione-regulated potassium exporter activity
AMETH_2713	COG1160	GTP binding
AMETH_2716	COG4213	ABC transporter substrate-binding protein
AMETH_2718	COG4214	carbohydrate transport
AMETH_2731	COG0583	DNA-binding transcription factor activity
AMETH_2732	COG2851	Citrate transporter
AMETH_2739	COG1136	(ABC) transporter
AMETH_2739	COG0577	efflux transmembrane transporter activity
AMETH_2741	COG2124	cytochrome p450
AMETH_2743	COG1414	Transcriptional regulator
AMETH_2744	COG0745	RESPONSE REGULATOR receiver
AMETH_2746	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_2747	COG1116	anion transmembrane transporter activity
AMETH_2748	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMETH_2749	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2751	COG0506	proline dehydrogenase activity
AMETH_2752	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_2753	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMETH_2753	COG2508	Transcriptional regulator
AMETH_2755	COG1309	transcriptional regulator
AMETH_2756	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMETH_2757	COG3281	Trehalose synthase
AMETH_2758	COG0366	Alpha amylase catalytic
AMETH_2759	COG0366	Alpha amylase catalytic
AMETH_2769	COG2843	Capsule synthesis protein
AMETH_2773	COG1940	carbohydrate kinase activity
AMETH_2776	COG1129	ABC transporter
AMETH_2777	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_2778	COG1879	ABC-type sugar transport system periplasmic component
AMETH_2781	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMETH_2788	COG1802	Transcriptional regulator
AMETH_2789	COG0628	permease
AMETH_2790	COG1268	BioY protein
AMETH_2793	COG1122	ATPase activity
AMETH_2796	COG1982	Orn Lys Arg decarboxylase major
AMETH_2802	COG1024	Enoyl-CoA hydratase
AMETH_2802	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_2804	COG1063	alcohol dehydrogenase
AMETH_2805	COG1410	methionine synthase
AMETH_2805	COG0646	methionine synthase
AMETH_2810	COG2115	Belongs to the xylose isomerase family
AMETH_2811	COG3842	ATPase activity
AMETH_2812	COG1940	carbohydrate kinase activity
AMETH_2813	COG0604	alcohol dehydrogenase
AMETH_2813	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_2813	COG3321	synthase
AMETH_2816	COG1802	Transcriptional regulator
AMETH_2821	COG2226	methyltransferase
AMETH_2824	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMETH_2825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMETH_2826	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_2834	COG0583	DNA-binding transcription factor activity
AMETH_2836	COG1280	lysine exporter protein (LysE YggA)
AMETH_2844	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMETH_2846	COG1216	Glycosyl transferase, family 2
AMETH_2851	COG0110	maltose O-acetyltransferase activity
AMETH_2854	COG1215	transferase activity, transferring glycosyl groups
AMETH_2856	COG0778	Nitroreductase
AMETH_2860	COG1846	Transcriptional regulator
AMETH_2862	COG1560	Kdo2-lipid A biosynthetic process
AMETH_2863	COG0438	transferase activity, transferring glycosyl groups
AMETH_2865	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMETH_2865	COG3608	succinylglutamate desuccinylase aspartoacylase
AMETH_2868	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AMETH_2869	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AMETH_2870	COG0217	transcriptional regulatory protein
AMETH_2872	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMETH_2873	COG0632	four-way junction helicase activity
AMETH_2874	COG2255	four-way junction helicase activity
AMETH_2876	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMETH_2877	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMETH_2878	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMETH_2879	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMETH_2888	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMETH_2890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AMETH_2893	COG2040	homocysteine
AMETH_2895	COG2124	cytochrome p450
AMETH_2898	COG2272	Belongs to the type-B carboxylesterase lipase family
AMETH_2902	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2904	COG1051	belongs to the nudix hydrolase family
AMETH_2905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMETH_2905	COG2755	lipolytic protein G-D-S-L family
AMETH_2909	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_2910	COG1120	ATPase activity
AMETH_2930	COG0596	Alpha beta hydrolase
AMETH_2931	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMETH_2937	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_2938	COG1064	alcohol dehydrogenase
AMETH_2943	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMETH_2944	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_2945	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_2955	COG0411	ABC transporter
AMETH_2960	COG0346	lactoylglutathione lyase activity
AMETH_2962	COG4941	Belongs to the sigma-70 factor family
AMETH_2965	COG1309	transcriptional regulator
AMETH_2966	COG1511	domain protein
AMETH_2969	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMETH_2970	COG0539	negative regulation of cytoplasmic translation
AMETH_2972	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMETH_2979	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_2981	COG2211	Major facilitator Superfamily
AMETH_2983	COG0523	cobalamin synthesis protein
AMETH_2987	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMETH_2989	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMETH_2990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMETH_2992	COG1648	precorrin-2 dehydrogenase activity
AMETH_2992	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMETH_2995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_3000	COG1716	ATPase activity
AMETH_3011	COG3572	ergothioneine biosynthetic process
AMETH_3012	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMETH_3013	COG0121	glutamine amidotransferase
AMETH_3014	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AMETH_3018	COG4941	Belongs to the sigma-70 factor family
AMETH_3019	COG2409	Drug exporters of the RND superfamily
AMETH_3020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMETH_3023	COG0791	NLP P60 protein
AMETH_3023	COG3883	PFAM NLP P60 protein
AMETH_3024	COG0746	molybdenum cofactor guanylyltransferase activity
AMETH_3025	COG0714	Associated with various cellular activities
AMETH_3027	COG2304	oxidoreductase activity
AMETH_3030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMETH_3031	COG3540	Alkaline phosphatase
AMETH_3032	COG2226	methyltransferase
AMETH_3035	COG2205	protein histidine kinase activity
AMETH_3036	COG0745	RESPONSE REGULATOR receiver
AMETH_3037	COG0477	Major facilitator Superfamily
AMETH_3039	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMETH_3043	COG0516	GMP reductase activity
AMETH_3043	COG0517	IMP dehydrogenase activity
AMETH_3044	COG0589	response to stress
AMETH_3045	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AMETH_3046	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMETH_3056	COG2326	polyphosphate kinase activity
AMETH_3066	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_3068	COG2080	2 iron, 2 sulfur cluster binding
AMETH_3072	COG0640	Transcriptional regulator
AMETH_3073	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_3074	COG1993	acr, cog1993
AMETH_3075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_3083	COG0477	Major facilitator Superfamily
AMETH_3086	COG1960	acyl-CoA dehydrogenase activity
AMETH_3087	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_3090	COG3850	Histidine kinase
AMETH_3091	COG2197	response regulator
AMETH_3093	COG0477	Major facilitator Superfamily
AMETH_3096	COG0531	amino acid
AMETH_3101	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3102	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AMETH_3106	COG4336	lyase activity
AMETH_3109	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_3111	COG1175	transmembrane transport
AMETH_3112	COG0395	ABC-type sugar transport system, permease component
AMETH_3113	COG3842	ATPase activity
AMETH_3115	COG1940	carbohydrate kinase activity
AMETH_3116	COG2971	BadF BadG BcrA BcrD
AMETH_3117	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMETH_3118	COG2843	Capsule synthesis protein
AMETH_3120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_3123	COG0154	amidase activity
AMETH_3126	COG3328	transposase activity
AMETH_3128	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AMETH_3139	COG0798	PFAM Bile acid sodium symporter
AMETH_3140	COG0640	Transcriptional regulator
AMETH_3141	COG2226	methyltransferase
AMETH_3143	COG2072	flavoprotein involved in K transport
AMETH_3146	COG1247	-acetyltransferase
AMETH_3154	COG0697	spore germination
AMETH_3159	COG2226	methyltransferase
AMETH_3164	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMETH_3165	COG0477	Major facilitator Superfamily
AMETH_3168	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_3169	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3171	COG1024	Enoyl-CoA hydratase
AMETH_3177	COG1960	acyl-CoA dehydrogenase activity
AMETH_3178	COG1960	acyl-CoA dehydrogenase activity
AMETH_3181	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_3183	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3185	COG1960	acyl-CoA dehydrogenase activity
AMETH_3186	COG1960	acyl-CoA dehydrogenase activity
AMETH_3187	COG1802	Transcriptional regulator
AMETH_3191	COG0183	Belongs to the thiolase family
AMETH_3198	COG4638	Rieske (2fe-2S)
AMETH_3199	COG0456	acetyltransferase
AMETH_3199	COG0454	-acetyltransferase
AMETH_3205	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_3207	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_3208	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_3209	COG1127	ABC transporter
AMETH_3220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_3222	COG1024	Enoyl-CoA hydratase
AMETH_3226	COG1024	Enoyl-CoA hydratase
AMETH_3230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMETH_3240	COG2151	metal-sulfur cluster biosynthetic enzyme
AMETH_3245	COG1937	Protein conserved in bacteria
AMETH_3248	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMETH_3249	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMETH_3250	COG0156	8-amino-7-oxononanoate synthase activity
AMETH_3254	COG1846	Transcriptional regulator
AMETH_3273	COG3387	PFAM Glycoside hydrolase 15-related
AMETH_3277	COG0477	Major facilitator Superfamily
AMETH_3278	COG0628	permease
AMETH_3281	COG2326	polyphosphate kinase activity
AMETH_3282	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMETH_3284	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMETH_3285	COG0483	inositol monophosphate 1-phosphatase activity
AMETH_3286	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_3289	COG0438	transferase activity, transferring glycosyl groups
AMETH_3295	COG0583	DNA-binding transcription factor activity
AMETH_3297	COG2814	Major facilitator Superfamily
AMETH_3300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMETH_3301	COG2755	lipolytic protein G-D-S-L family
AMETH_3307	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMETH_3311	COG0640	Transcriptional regulator
AMETH_3315	COG4941	Belongs to the sigma-70 factor family
AMETH_3318	COG5479	isomerase activity
AMETH_3318	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_3336	COG1846	Transcriptional regulator
AMETH_3337	COG0783	Belongs to the Dps family
AMETH_3339	COG1846	Transcriptional regulator
AMETH_3340	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AMETH_3344	COG2072	flavoprotein involved in K transport
AMETH_3357	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_3360	COG0656	L-ascorbic acid biosynthetic process
AMETH_3361	COG2814	Major facilitator Superfamily
AMETH_3369	COG0601	transmembrane transport
AMETH_3370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_3373	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3378	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_3391	COG1309	transcriptional regulator
AMETH_3396	COG3383	formate dehydrogenase (NAD+) activity
AMETH_3396	COG0243	molybdopterin cofactor binding
AMETH_3397	COG0243	molybdopterin cofactor binding
AMETH_3397	COG3383	formate dehydrogenase (NAD+) activity
AMETH_3398	COG0437	4 iron, 4 sulfur cluster binding
AMETH_3401	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_3401	COG1017	nitric oxide dioxygenase activity
AMETH_3402	COG1472	Belongs to the glycosyl hydrolase 3 family
AMETH_3404	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_3408	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3415	COG0667	Aldo Keto reductase
AMETH_3416	COG1968	undecaprenyl-diphosphatase activity
AMETH_3418	COG0339	signal peptide processing
AMETH_3421	COG0039	L-malate dehydrogenase activity
AMETH_3428	COG0789	Transcriptional regulator
AMETH_3431	COG4166	transmembrane transport
AMETH_3432	COG0601	transmembrane transport
AMETH_3433	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_3434	COG4172	Belongs to the ABC transporter superfamily
AMETH_3437	COG1619	proteins homologs of microcin C7 resistance protein MccF
AMETH_3438	COG4946	Tricorn protease homolog
AMETH_3438	COG0823	Involved in the tonB-independent uptake of proteins
AMETH_3438	COG1506	peptidase
AMETH_3441	COG1595	DNA-templated transcription, initiation
AMETH_3450	COG1733	regulation of RNA biosynthetic process
AMETH_3455	COG0477	Major facilitator Superfamily
AMETH_3458	COG1595	DNA-templated transcription, initiation
AMETH_3465	COG1056	cytidyltransferase-related domain
AMETH_3465	COG1051	belongs to the nudix hydrolase family
AMETH_3470	COG2860	membrane
AMETH_3472	COG2813	Specifically methylates the guanine in position
AMETH_3473	COG0583	DNA-binding transcription factor activity
AMETH_3475	COG2890	protein-(glutamine-N5) methyltransferase activity
AMETH_3478	COG1802	Transcriptional regulator
AMETH_3485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMETH_3491	COG1435	thymidine kinase activity
AMETH_3494	COG0463	Glycosyl transferase, family 2
AMETH_3496	COG1228	amidohydrolase
AMETH_3497	COG1509	lysine 2,3-aminomutase activity
AMETH_3513	COG4152	abc transporter atp-binding protein
AMETH_3515	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3516	COG4221	oxidoreductase activity
AMETH_3523	COG4552	Acetyltransferase involved in intracellular survival and related
AMETH_3530	COG2378	regulation of single-species biofilm formation
AMETH_3531	COG2378	regulation of single-species biofilm formation
AMETH_3533	COG2409	Drug exporters of the RND superfamily
AMETH_3535	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMETH_3536	COG1357	PFAM Pentapeptide repeats (8 copies)
AMETH_3537	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMETH_3538	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMETH_3546	COG1222	aaa ATPase
AMETH_3550	COG0517	IMP dehydrogenase activity
AMETH_3550	COG1994	Peptidase M50
AMETH_3555	COG4941	Belongs to the sigma-70 factor family
AMETH_3556	COG3795	YCII-related domain
AMETH_3559	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMETH_3560	COG0140	phosphoribosyl-ATP diphosphatase activity
AMETH_3561	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMETH_3562	COG1410	methionine synthase
AMETH_3562	COG0646	methionine synthase
AMETH_3567	COG0488	(ABC) transporter
AMETH_3568	COG0215	cysteine-tRNA ligase activity
AMETH_3575	COG4867	von Willebrand factor, type A
AMETH_3583	COG1228	amidohydrolase
AMETH_3590	COG2186	Transcriptional regulator
AMETH_3592	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_3593	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_3596	COG1129	ABC transporter
AMETH_3597	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_3599	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMETH_3605	COG2409	Drug exporters of the RND superfamily
AMETH_3607	COG2159	amidohydrolase
AMETH_3609	COG2814	Major facilitator Superfamily
AMETH_3609	COG0477	Major facilitator Superfamily
AMETH_3615	COG0477	Major facilitator Superfamily
AMETH_3625	COG0009	L-threonylcarbamoyladenylate synthase
AMETH_3629	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_3632	COG2814	Major facilitator Superfamily
AMETH_3636	COG0243	molybdopterin cofactor binding
AMETH_3638	COG1063	alcohol dehydrogenase
AMETH_3639	COG0477	Major facilitator Superfamily
AMETH_3641	COG2072	flavoprotein involved in K transport
AMETH_3645	COG2144	transferase activity, transferring acyl groups
AMETH_3646	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMETH_3649	COG0492	ferredoxin-NADP+ reductase activity
AMETH_3655	COG1937	Protein conserved in bacteria
AMETH_3660	COG0589	response to stress
AMETH_3665	COG0022	dehydrogenase e1 component
AMETH_3671	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3672	COG1024	Enoyl-CoA hydratase
AMETH_3673	COG1960	acyl-CoA dehydrogenase activity
AMETH_3675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AMETH_3677	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMETH_3679	COG0129	dihydroxy-acid dehydratase activity
AMETH_3680	COG1053	succinate dehydrogenase
AMETH_3680	COG3976	FMN-binding domain protein
AMETH_3683	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMETH_3684	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMETH_3688	COG4585	Histidine kinase
AMETH_3689	COG2197	response regulator
AMETH_3692	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_3696	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_3697	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_3700	COG0513	Belongs to the DEAD box helicase family
AMETH_3701	COG0477	Major facilitator Superfamily
AMETH_3706	COG0668	transmembrane transport
AMETH_3726	COG0110	maltose O-acetyltransferase activity
AMETH_3729	COG1473	amidohydrolase
AMETH_3733	COG1595	DNA-templated transcription, initiation
AMETH_3735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_3736	COG1414	Transcriptional regulator
AMETH_3738	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_3739	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMETH_3745	COG3104	oligopeptide transport
AMETH_3746	COG1228	amidohydrolase
AMETH_3750	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_3751	COG2814	Major facilitator Superfamily
AMETH_3756	COG0183	Belongs to the thiolase family
AMETH_3763	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3765	COG0477	Major facilitator Superfamily
AMETH_3768	COG2197	response regulator
AMETH_3778	COG0589	response to stress
AMETH_3779	COG2814	Major facilitator Superfamily
AMETH_3780	COG1082	Xylose isomerase domain protein TIM barrel
AMETH_3781	COG0673	inositol 2-dehydrogenase activity
AMETH_3785	COG0714	Associated with various cellular activities
AMETH_3787	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AMETH_3790	COG0137	argininosuccinate synthase activity
AMETH_3797	COG1802	Transcriptional regulator
AMETH_3799	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_3801	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AMETH_3803	COG0596	Alpha beta hydrolase
AMETH_3805	COG4249	Peptidase C14 caspase catalytic subunit p20
AMETH_3805	COG2319	Wd-40 repeat
AMETH_3808	COG1414	Transcriptional regulator
AMETH_3809	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMETH_3810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_3811	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_3812	COG2610	gluconate transmembrane transporter activity
AMETH_3815	COG3655	Transcriptional regulator
AMETH_3817	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_3818	COG1116	anion transmembrane transporter activity
AMETH_3823	COG0596	Alpha beta hydrolase
AMETH_3838	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3839	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMETH_3840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMETH_3840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMETH_3842	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMETH_3843	COG1492	cobalamin metabolic process
AMETH_3844	COG2205	protein histidine kinase activity
AMETH_3850	COG0671	phosphoesterase, PA-phosphatase related
AMETH_3852	COG0277	FAD linked oxidase domain protein
AMETH_3853	COG0277	FAD linked oxidase domain protein
AMETH_3854	COG0247	lactate metabolic process
AMETH_3855	COG1620	l-lactate permease
AMETH_3856	COG1486	melibiose metabolic process
AMETH_3858	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMETH_3875	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_3879	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_3880	COG1063	alcohol dehydrogenase
AMETH_3881	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_3895	COG0477	Major facilitator Superfamily
AMETH_3896	COG2508	Transcriptional regulator
AMETH_3896	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMETH_3897	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_3901	COG4608	Belongs to the ABC transporter superfamily
AMETH_3902	COG0444	Belongs to the ABC transporter superfamily
AMETH_3903	COG0601	transmembrane transport
AMETH_3906	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_3907	COG0129	dihydroxy-acid dehydratase activity
AMETH_3911	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMETH_3913	COG1201	RNA secondary structure unwinding
AMETH_3918	COG1609	Transcriptional regulator
AMETH_3919	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_3920	COG0477	Major facilitator Superfamily
AMETH_3923	COG0564	pseudouridine synthase activity
AMETH_3926	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_3929	COG0667	Aldo Keto reductase
AMETH_3930	COG0667	Aldo Keto reductase
AMETH_3937	COG0747	negative chemotaxis
AMETH_3938	COG0583	DNA-binding transcription factor activity
AMETH_3942	COG0596	Alpha beta hydrolase
AMETH_3943	COG1335	isochorismatase
AMETH_3948	COG0477	Major facilitator Superfamily
AMETH_3950	COG3473	Maleate cis-trans isomerase
AMETH_3951	COG2309	aminopeptidase activity
AMETH_3955	COG0596	Alpha beta hydrolase
AMETH_3957	COG0697	spore germination
AMETH_3958	COG0583	DNA-binding transcription factor activity
AMETH_3964	COG3665	Urea carboxylase-associated protein
AMETH_3966	COG3953	SLT domain
AMETH_3966	COG5280	Phage tail tape measure protein TP901
AMETH_3969	COG2271	Major facilitator Superfamily
AMETH_3971	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_3976	COG0583	DNA-binding transcription factor activity
AMETH_3981	COG4608	Belongs to the ABC transporter superfamily
AMETH_3982	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_3989	COG0740	serine-type endopeptidase activity
AMETH_3990	COG2197	response regulator
AMETH_3994	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AMETH_3996	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_3997	COG0477	Major facilitator Superfamily
AMETH_3999	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_4001	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_4005	COG1063	alcohol dehydrogenase
AMETH_4009	COG2318	DinB family
AMETH_4010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMETH_4010	COG1796	DNA polymerase
AMETH_4016	COG5650	phosphatidylinositol metabolic process
AMETH_4017	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AMETH_4018	COG0667	Aldo Keto reductase
AMETH_4024	COG1960	acyl-CoA dehydrogenase activity
AMETH_4025	COG1960	acyl-CoA dehydrogenase activity
AMETH_4026	COG1309	transcriptional regulator
AMETH_4027	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4028	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4029	COG1309	transcriptional regulator
AMETH_4030	COG0596	Alpha beta hydrolase
AMETH_4037	COG1309	transcriptional regulator
AMETH_4040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_4041	COG1960	acyl-CoA dehydrogenase activity
AMETH_4044	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMETH_4044	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_4045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_4048	COG5001	Diguanylate cyclase
AMETH_4051	COG1316	TRANSCRIPTIONal
AMETH_4053	COG4821	SIS domain
AMETH_4054	COG1132	(ABC) transporter
AMETH_4057	COG0488	(ABC) transporter
AMETH_4058	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AMETH_4059	COG5001	Diguanylate cyclase
AMETH_4059	COG2203	Gaf domain
AMETH_4059	COG4251	negative regulation of phosphorylation
AMETH_4059	COG3706	GGDEF domain
AMETH_4061	COG2151	metal-sulfur cluster biosynthetic enzyme
AMETH_4062	COG0822	iron-sulfur transferase activity
AMETH_4064	COG0396	ATPase activity
AMETH_4069	COG1131	(ABC) transporter
AMETH_4077	COG1657	PFAM Prenyltransferase squalene oxidase
AMETH_4079	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AMETH_4083	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMETH_4087	COG0697	spore germination
AMETH_4088	COG0300	oxidoreductase activity
AMETH_4090	COG3973	AAA domain
AMETH_4091	COG0109	protoheme IX farnesyltransferase activity
AMETH_4093	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMETH_4094	COG0166	Belongs to the GPI family
AMETH_4097	COG0363	glucosamine-6-phosphate deaminase activity
AMETH_4099	COG4585	Histidine kinase
AMETH_4102	COG0149	triose-phosphate isomerase activity
AMETH_4103	COG0126	phosphoglycerate kinase activity
AMETH_4104	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMETH_4113	COG1846	Transcriptional regulator
AMETH_4116	COG0463	Glycosyl transferase, family 2
AMETH_4118	COG5002	protein histidine kinase activity
AMETH_4119	COG0745	RESPONSE REGULATOR receiver
AMETH_4121	COG1481	regulation of sporulation
AMETH_4123	COG1660	Displays ATPase and GTPase activities
AMETH_4124	COG0322	excinuclease ABC activity
AMETH_4127	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMETH_4128	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_4128	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_4133	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMETH_4134	COG0405	Gamma-glutamyltransferase
AMETH_4137	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMETH_4139	COG1758	RNA polymerase activity
AMETH_4140	COG0194	GDP metabolic process
AMETH_4142	COG0284	orotidine-5'-phosphate decarboxylase activity
AMETH_4144	COG0505	Belongs to the CarA family
AMETH_4147	COG0540	Belongs to the ATCase OTCase family
AMETH_4148	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AMETH_4150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMETH_4151	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMETH_4155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMETH_4156	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMETH_4157	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMETH_4158	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMETH_4159	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMETH_4160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMETH_4166	COG2190	(PTS) system
AMETH_4167	COG1263	PTS System
AMETH_4167	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMETH_4169	COG2190	(PTS) system
AMETH_4169	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMETH_4169	COG1263	PTS System
AMETH_4170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_4171	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_4175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMETH_4178	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMETH_4186	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMETH_4190	COG1733	regulation of RNA biosynthetic process
AMETH_4191	COG0156	8-amino-7-oxononanoate synthase activity
AMETH_4195	COG0702	epimerase
AMETH_4196	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_4197	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_4199	COG0386	Belongs to the glutathione peroxidase family
AMETH_4203	COG1252	NADH dehydrogenase
AMETH_4205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMETH_4207	COG1473	amidohydrolase
AMETH_4213	COG1414	Transcriptional regulator
AMETH_4219	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_4230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMETH_4231	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4236	COG1215	transferase activity, transferring glycosyl groups
AMETH_4240	COG2197	response regulator
AMETH_4243	COG0439	Biotin carboxylase
AMETH_4245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_4247	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_4256	COG0477	Major facilitator Superfamily
AMETH_4258	COG0583	DNA-binding transcription factor activity
AMETH_4259	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMETH_4260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMETH_4261	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_4262	COG1960	acyl-CoA dehydrogenase activity
AMETH_4263	COG0431	NADPH-dependent FMN reductase
AMETH_4269	COG1278	Cold shock
AMETH_4270	COG1940	carbohydrate kinase activity
AMETH_4271	COG0673	inositol 2-dehydrogenase activity
AMETH_4276	COG1522	sequence-specific DNA binding
AMETH_4283	COG2376	Dihydroxyacetone kinase
AMETH_4284	COG1414	Transcriptional regulator
AMETH_4290	COG0477	Major facilitator Superfamily
AMETH_4296	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_4302	COG0542	response to heat
AMETH_4306	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_4311	COG2226	methyltransferase
AMETH_4315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMETH_4316	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_4319	COG0459	protein refolding
AMETH_4325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_4330	COG0640	Transcriptional regulator
AMETH_4331	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMETH_4343	COG2175	clavaminate synthase activity
AMETH_4344	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
AMETH_4347	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMETH_4350	COG0726	polysaccharide deacetylase
AMETH_4351	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_4357	COG2272	Belongs to the type-B carboxylesterase lipase family
AMETH_4359	COG2018	Roadblock/LC7 domain
AMETH_4369	COG4941	Belongs to the sigma-70 factor family
AMETH_4370	COG3795	YCII-related domain
AMETH_4371	COG0135	phosphoribosylanthranilate isomerase activity
AMETH_4378	COG0463	Glycosyl transferase, family 2
AMETH_4387	COG1309	transcriptional regulator
AMETH_4389	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4393	COG0596	Alpha beta hydrolase
AMETH_4397	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_4398	COG3622	Belongs to the hyi family
AMETH_4401	COG3511	phospholipase C
AMETH_4405	COG2018	Roadblock/LC7 domain
AMETH_4408	COG3033	Beta-eliminating lyase
AMETH_4411	COG1024	Enoyl-CoA hydratase
AMETH_4412	COG3012	SEC-C Motif Domain Protein
AMETH_4419	COG2271	Major facilitator Superfamily
AMETH_4427	COG2072	flavoprotein involved in K transport
AMETH_4434	COG3835	regulator
AMETH_4450	COG2226	methyltransferase
AMETH_4454	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMETH_4454	COG0426	domain, Protein
AMETH_4455	COG1960	acyl-CoA dehydrogenase activity
AMETH_4457	COG1960	acyl-CoA dehydrogenase activity
AMETH_4458	COG1024	Enoyl-CoA hydratase
AMETH_4459	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_4460	COG1960	acyl-CoA dehydrogenase activity
AMETH_4462	COG0183	Belongs to the thiolase family
AMETH_4466	COG1024	Enoyl-CoA hydratase
AMETH_4467	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4470	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4472	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMETH_4479	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMETH_4480	COG4638	Rieske (2fe-2S)
AMETH_4481	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMETH_4488	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMETH_4489	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMETH_4491	COG1760	l-serine dehydratase
AMETH_4493	COG1414	Transcriptional regulator
AMETH_4494	COG2146	nitrite reductase [NAD(P)H] activity
AMETH_4495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_4496	COG3226	Transcriptional regulator
AMETH_4502	COG1960	acyl-CoA dehydrogenase activity
AMETH_4503	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_4505	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_4507	COG2030	dehydratase
AMETH_4508	COG0477	Major facilitator Superfamily
AMETH_4513	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMETH_4514	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMETH_4516	COG1494	fructose-1,6-bisphosphatase
AMETH_4522	COG3279	Response regulator of the LytR AlgR family
AMETH_4526	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMETH_4531	COG3588	fructose-bisphosphate aldolase
AMETH_4532	COG0583	DNA-binding transcription factor activity
AMETH_4534	COG0535	radical SAM domain protein
AMETH_4537	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMETH_4546	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4548	COG1024	Enoyl-CoA hydratase
AMETH_4551	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_4552	COG1024	Enoyl-CoA hydratase
AMETH_4553	COG0183	Belongs to the thiolase family
AMETH_4555	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4556	COG1960	acyl-CoA dehydrogenase activity
AMETH_4559	COG3293	Transposase
AMETH_4563	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_4574	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMETH_4579	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_4580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_4581	COG1309	transcriptional regulator
AMETH_4583	COG3284	Transcriptional regulator
AMETH_4584	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_4585	COG1063	alcohol dehydrogenase
AMETH_4587	COG0477	Major facilitator Superfamily
AMETH_4588	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMETH_4590	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_4593	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_4596	COG0477	Major facilitator Superfamily
AMETH_4597	COG1609	Transcriptional regulator
AMETH_4598	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMETH_4600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AMETH_4611	COG0640	Transcriptional regulator
AMETH_4612	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_4612	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_4614	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_4615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_4618	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_4620	COG1968	undecaprenyl-diphosphatase activity
AMETH_4621	COG0745	RESPONSE REGULATOR receiver
AMETH_4624	COG2197	response regulator
AMETH_4630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_4631	COG1024	Enoyl-CoA hydratase
AMETH_4634	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMETH_4635	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4636	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_4636	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_4645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_4651	COG1957	nucleoside hydrolase
AMETH_4652	COG2271	Major facilitator Superfamily
AMETH_4653	COG1349	DNA-binding transcription factor activity
AMETH_4654	COG1063	alcohol dehydrogenase
AMETH_4655	COG1830	Aldolase
AMETH_4658	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMETH_4659	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_4660	COG0277	FAD linked oxidase domain protein
AMETH_4676	COG3237	CsbD-like
AMETH_4679	COG1556	Lactate utilization protein
AMETH_4681	COG0247	lactate metabolic process
AMETH_4683	COG2186	Transcriptional regulator
AMETH_4684	COG1802	Transcriptional regulator
AMETH_4685	COG4770	biotin carboxylase activity
AMETH_4689	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_4690	COG1024	Enoyl-CoA hydratase
AMETH_4691	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_4693	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMETH_4713	COG0174	glutamine synthetase
AMETH_4720	COG0640	Transcriptional regulator
AMETH_4723	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMETH_4725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMETH_4727	COG1793	dna ligase
AMETH_4731	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_4736	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMETH_4740	COG3220	belongs to the UPF0276 family
AMETH_4742	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_4745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMETH_4747	COG2197	response regulator
AMETH_4749	COG0183	Belongs to the thiolase family
AMETH_4750	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_4750	COG1024	Enoyl-CoA hydratase
AMETH_4752	COG0154	amidase activity
AMETH_4753	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMETH_4756	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_4757	COG1846	Transcriptional regulator
AMETH_4758	COG0656	L-ascorbic acid biosynthetic process
AMETH_4759	COG2205	protein histidine kinase activity
AMETH_4760	COG0745	RESPONSE REGULATOR receiver
AMETH_4767	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMETH_4770	COG1053	succinate dehydrogenase
AMETH_4771	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMETH_4773	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMETH_4774	COG0531	amino acid
AMETH_4775	COG0569	domain protein
AMETH_4782	COG0756	dUTP diphosphatase activity
AMETH_4786	COG0483	inositol monophosphate 1-phosphatase activity
AMETH_4789	COG0531	amino acid
AMETH_4796	COG1942	4-Oxalocrotonate Tautomerase
AMETH_4798	COG2313	pseudouridylate synthase activity
AMETH_4801	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_4802	COG2318	DinB family
AMETH_4803	COG1473	amidohydrolase
AMETH_4805	COG1490	D-aminoacyl-tRNA deacylase activity
AMETH_4811	COG4941	Belongs to the sigma-70 factor family
AMETH_4813	COG2070	2-Nitropropane dioxygenase
AMETH_4822	COG2124	cytochrome p450
AMETH_4823	COG0183	Belongs to the thiolase family
AMETH_4825	COG2226	methyltransferase
AMETH_4827	COG0583	DNA-binding transcription factor activity
AMETH_4829	COG1733	regulation of RNA biosynthetic process
AMETH_4830	COG0702	epimerase
AMETH_4834	COG2814	Major facilitator Superfamily
AMETH_4835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMETH_4836	COG0346	lactoylglutathione lyase activity
AMETH_4837	COG2267	carboxylic ester hydrolase activity
AMETH_4838	COG1960	acyl-CoA dehydrogenase activity
AMETH_4849	COG2030	dehydratase
AMETH_4850	COG1960	acyl-CoA dehydrogenase activity
AMETH_4851	COG1960	acyl-CoA dehydrogenase activity
AMETH_4852	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMETH_4854	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMETH_4855	COG1960	acyl-CoA dehydrogenase activity
AMETH_4856	COG1309	transcriptional regulator
AMETH_4860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMETH_4861	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_4863	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_4863	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMETH_4863	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMETH_4865	COG1349	DNA-binding transcription factor activity
AMETH_4866	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMETH_4866	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMETH_4866	COG1703	isobutyryl-CoA mutase activity
AMETH_4869	COG2018	Roadblock/LC7 domain
AMETH_4872	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_4874	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMETH_4880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_4884	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMETH_4885	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_4886	COG1672	PFAM Archaeal ATPase
AMETH_4886	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMETH_4891	COG1946	Acyl-CoA thioesterase
AMETH_4893	COG2226	methyltransferase
AMETH_4900	COG0204	Acyl-transferase
AMETH_4903	COG1929	Belongs to the glycerate kinase type-1 family
AMETH_4904	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_4909	COG2890	protein-(glutamine-N5) methyltransferase activity
AMETH_4912	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMETH_4913	COG0723	plastoquinol--plastocyanin reductase activity
AMETH_4920	COG1573	uracil-dna glycosylase
AMETH_4924	COG1278	Cold shock
AMETH_4927	COG2080	2 iron, 2 sulfur cluster binding
AMETH_4928	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_4928	COG2010	Cytochrome c
AMETH_4933	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMETH_4933	COG1902	pentaerythritol trinitrate reductase activity
AMETH_4934	COG1902	pentaerythritol trinitrate reductase activity
AMETH_4934	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMETH_4936	COG0535	radical SAM domain protein
AMETH_4940	COG1940	carbohydrate kinase activity
AMETH_4942	COG0003	Pfam Anion-transporting ATPase
AMETH_4946	COG1022	Amp-dependent synthetase and ligase
AMETH_4957	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_4958	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_4960	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_4961	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_4963	COG1960	acyl-CoA dehydrogenase activity
AMETH_4964	COG1960	acyl-CoA dehydrogenase activity
AMETH_4965	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_4968	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMETH_4970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AMETH_4971	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMETH_4975	COG0516	GMP reductase activity
AMETH_4975	COG0517	IMP dehydrogenase activity
AMETH_4978	COG1505	serine-type exopeptidase activity
AMETH_4982	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMETH_4984	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMETH_4986	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMETH_4989	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMETH_4991	COG1196	nuclear chromosome segregation
AMETH_4995	COG2814	Major facilitator Superfamily
AMETH_4996	COG0583	DNA-binding transcription factor activity
AMETH_4997	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMETH_4999	COG1126	abc transporter atp-binding protein
AMETH_5001	COG0765	amino acid transport
AMETH_5002	COG0765	amino acid transport
AMETH_5005	COG3842	ATPase activity
AMETH_5009	COG1940	carbohydrate kinase activity
AMETH_5012	COG1053	succinate dehydrogenase
AMETH_5016	COG0800	Aldolase
AMETH_5018	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_5021	COG2137	regulation of response to DNA damage stimulus
AMETH_5022	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMETH_5025	COG0443	Heat shock 70 kDa protein
AMETH_5026	COG1201	RNA secondary structure unwinding
AMETH_5027	COG0242	peptide deformylase activity
AMETH_5033	COG5504	Zn-dependent protease
AMETH_5037	COG0697	spore germination
AMETH_5041	COG0583	DNA-binding transcription factor activity
AMETH_5044	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AMETH_5045	COG1396	sequence-specific DNA binding
AMETH_5048	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_5052	COG0515	serine threonine protein kinase
AMETH_5052	COG2815	serine threonine protein kinase
AMETH_5053	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMETH_5055	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMETH_5060	COG0070	glutamate synthase
AMETH_5060	COG0067	glutamate synthase
AMETH_5060	COG0069	glutamate synthase activity
AMETH_5062	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_5063	COG1120	ATPase activity
AMETH_5066	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMETH_5070	COG0159	tryptophan synthase activity
AMETH_5071	COG0133	tryptophan synthase activity
AMETH_5072	COG0134	indole-3-glycerol-phosphate synthase activity
AMETH_5074	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMETH_5076	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMETH_5077	COG0107	imidazoleglycerol-phosphate synthase activity
AMETH_5080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMETH_5081	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMETH_5083	COG3958	Transketolase
AMETH_5084	COG3958	Transketolase
AMETH_5085	COG3959	Transketolase, thiamine diphosphate binding domain
AMETH_5088	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AMETH_5090	COG1309	transcriptional regulator
AMETH_5091	COG2409	Drug exporters of the RND superfamily
AMETH_5093	COG0131	Imidazoleglycerol-phosphate dehydratase
AMETH_5094	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMETH_5095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMETH_5097	COG2197	response regulator
AMETH_5100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMETH_5100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMETH_5101	COG4585	Histidine kinase
AMETH_5103	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AMETH_5109	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMETH_5110	COG0659	secondary active sulfate transmembrane transporter activity
AMETH_5111	COG0789	Transcriptional regulator
AMETH_5113	COG2124	cytochrome p450
AMETH_5116	COG0438	transferase activity, transferring glycosyl groups
AMETH_5122	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMETH_5124	COG2010	Cytochrome c
AMETH_5125	COG1845	cytochrome c oxidase, subunit III
AMETH_5128	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMETH_5130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMETH_5136	COG0667	Aldo Keto reductase
AMETH_5137	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMETH_5138	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMETH_5142	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMETH_5143	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_5145	COG1090	epimerase
AMETH_5147	COG0321	lipoyl(octanoyl) transferase activity
AMETH_5152	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMETH_5153	COG0586	Pfam SNARE associated Golgi protein
AMETH_5156	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMETH_5158	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMETH_5161	COG0587	DNA-directed DNA polymerase activity
AMETH_5162	COG1309	transcriptional regulator
AMETH_5165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMETH_5173	COG1397	ADP-ribosylglycohydrolase
AMETH_5177	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AMETH_5181	COG1620	l-lactate permease
AMETH_5182	COG3201	nicotinamide mononucleotide transporter
AMETH_5184	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMETH_5185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMETH_5186	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMETH_5199	COG0442	prolyl-tRNA aminoacylation
AMETH_5201	COG1414	Transcriptional regulator
AMETH_5205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMETH_5209	COG2186	Transcriptional regulator
AMETH_5210	COG0028	Belongs to the TPP enzyme family
AMETH_5211	COG1742	UPF0060 membrane protein
AMETH_5213	COG1946	Acyl-CoA thioesterase
AMETH_5221	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_5222	COG2151	metal-sulfur cluster biosynthetic enzyme
AMETH_5223	COG3396	Phenylacetate-CoA oxygenase
AMETH_5224	COG3460	Phenylacetate-CoA oxygenase
AMETH_5225	COG3396	Phenylacetate-CoA oxygenase
AMETH_5226	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_5226	COG2030	dehydratase
AMETH_5231	COG2814	Major facilitator Superfamily
AMETH_5233	COG1690	Belongs to the RtcB family
AMETH_5234	COG1522	sequence-specific DNA binding
AMETH_5239	COG2267	carboxylic ester hydrolase activity
AMETH_5240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_5241	COG1414	Transcriptional regulator
AMETH_5250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_5251	COG0697	spore germination
AMETH_5252	COG3285	dna ligase
AMETH_5252	COG1793	dna ligase
AMETH_5253	COG1672	PFAM Archaeal ATPase
AMETH_5253	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMETH_5254	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMETH_5256	COG3540	Alkaline phosphatase
AMETH_5257	COG4941	Belongs to the sigma-70 factor family
AMETH_5262	COG0242	peptide deformylase activity
AMETH_5270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_5272	COG2315	Protein conserved in bacteria
AMETH_5278	COG1846	Transcriptional regulator
AMETH_5280	COG0477	Major facilitator Superfamily
AMETH_5284	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_5292	COG0456	acetyltransferase
AMETH_5296	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMETH_5297	COG1414	Transcriptional regulator
AMETH_5298	COG2072	flavoprotein involved in K transport
AMETH_5306	COG3275	phosphorelay sensor kinase activity
AMETH_5307	COG3279	Response regulator of the LytR AlgR family
AMETH_5309	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_5311	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_5314	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_5315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_5316	COG3458	cephalosporin-C deacetylase activity
AMETH_5317	COG2186	Transcriptional regulator
AMETH_5318	COG0747	negative chemotaxis
AMETH_5322	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_5325	COG0596	Alpha beta hydrolase
AMETH_5327	COG1733	regulation of RNA biosynthetic process
AMETH_5330	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_5334	COG1609	Transcriptional regulator
AMETH_5348	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_5350	COG1643	Atp-dependent helicase
AMETH_5354	COG0475	glutathione-regulated potassium exporter activity
AMETH_5356	COG2814	Major facilitator Superfamily
AMETH_5363	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_5366	COG1120	ATPase activity
AMETH_5367	COG4122	O-methyltransferase activity
AMETH_5369	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMETH_5370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMETH_5370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMETH_5372	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_5373	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMETH_5383	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_5385	COG2226	methyltransferase
AMETH_5386	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_5389	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMETH_5390	COG1414	Transcriptional regulator
AMETH_5391	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMETH_5392	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMETH_5394	COG3485	protocatechuate 3,4-dioxygenase
AMETH_5395	COG3485	protocatechuate 3,4-dioxygenase
AMETH_5396	COG0183	Belongs to the thiolase family
AMETH_5397	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMETH_5398	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMETH_5400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMETH_5410	COG3268	Saccharopine dehydrogenase
AMETH_5418	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMETH_5420	COG3483	tryptophan 2,3-dioxygenase activity
AMETH_5421	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AMETH_5422	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMETH_5422	COG0235	Class ii aldolase
AMETH_5424	COG2197	response regulator
AMETH_5425	COG2197	response regulator
AMETH_5426	COG0410	ABC transporter
AMETH_5427	COG0411	ABC transporter
AMETH_5428	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_5429	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_5434	COG1136	(ABC) transporter
AMETH_5434	COG0577	efflux transmembrane transporter activity
AMETH_5440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMETH_5441	COG0067	glutamate synthase
AMETH_5441	COG0069	glutamate synthase activity
AMETH_5441	COG0070	glutamate synthase
AMETH_5446	COG1349	DNA-binding transcription factor activity
AMETH_5447	COG1492	cobalamin metabolic process
AMETH_5448	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMETH_5451	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AMETH_5452	COG2814	Major facilitator Superfamily
AMETH_5455	COG1797	cobyrinic acid a,c-diamide synthase activity
AMETH_5462	COG0778	Nitroreductase
AMETH_5466	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_5469	COG0037	tRNA processing
AMETH_5471	COG1309	transcriptional regulator
AMETH_5473	COG1024	Enoyl-CoA hydratase
AMETH_5479	COG1024	Enoyl-CoA hydratase
AMETH_5481	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_5489	COG1476	TRANSCRIPTIONal
AMETH_5491	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMETH_5495	COG3293	Transposase
AMETH_5498	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AMETH_5503	COG2183	response to ionizing radiation
AMETH_5507	COG1522	sequence-specific DNA binding
AMETH_5510	COG2910	NAD(P)H-binding
AMETH_5511	COG0431	NADPH-dependent FMN reductase
AMETH_5513	COG0277	FAD linked oxidase domain protein
AMETH_5517	COG2815	serine threonine protein kinase
AMETH_5517	COG0515	serine threonine protein kinase
AMETH_5523	COG1119	ATPase activity
AMETH_5526	COG0477	Major facilitator Superfamily
AMETH_5530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_5531	COG0058	SHG alpha-glucan phosphorylase activity
AMETH_5533	COG1846	Transcriptional regulator
AMETH_5537	COG0583	DNA-binding transcription factor activity
AMETH_5538	COG2409	Drug exporters of the RND superfamily
AMETH_5539	COG1609	Transcriptional regulator
AMETH_5542	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_5543	COG1879	ABC-type sugar transport system periplasmic component
AMETH_5546	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_5548	COG0183	Belongs to the thiolase family
AMETH_5555	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMETH_5561	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMETH_5563	COG1819	glycosyl
AMETH_5569	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMETH_5572	COG2197	response regulator
AMETH_5579	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_5581	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_5584	COG2226	methyltransferase
AMETH_5586	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMETH_5588	COG1414	Transcriptional regulator
AMETH_5592	COG1216	Glycosyl transferase, family 2
AMETH_5593	COG2205	protein histidine kinase activity
AMETH_5597	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_5598	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_5599	COG2172	sigma factor antagonist activity
AMETH_5618	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMETH_5618	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMETH_5636	COG0366	Alpha amylase catalytic
AMETH_5640	COG0514	ATP-dependent DNA helicase (RecQ)
AMETH_5642	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMETH_5649	COG3844	kynureninase activity
AMETH_5651	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_5652	COG2814	Major facilitator Superfamily
AMETH_5653	COG0745	RESPONSE REGULATOR receiver
AMETH_5653	COG3706	GGDEF domain
AMETH_5655	COG1316	TRANSCRIPTIONal
AMETH_5658	COG1309	transcriptional regulator
AMETH_5669	COG1595	DNA-templated transcription, initiation
AMETH_5671	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AMETH_5672	COG1309	transcriptional regulator
AMETH_5673	COG0477	Major facilitator Superfamily
AMETH_5674	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_5678	COG2814	Major facilitator Superfamily
AMETH_5678	COG0477	Major facilitator Superfamily
AMETH_5682	COG0484	heat shock protein binding
AMETH_5684	COG3800	Transcriptional regulator
AMETH_5684	COG1396	sequence-specific DNA binding
AMETH_5686	COG3340	Belongs to the peptidase S51 family
AMETH_5694	COG0655	NAD(P)H dehydrogenase (quinone) activity
AMETH_5695	COG1063	alcohol dehydrogenase
AMETH_5698	COG1595	DNA-templated transcription, initiation
AMETH_5700	COG0435	Glutathione S-transferase
AMETH_5703	COG0154	amidase activity
AMETH_5709	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMETH_5710	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_5712	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AMETH_5715	COG0028	Belongs to the TPP enzyme family
AMETH_5716	COG1024	Enoyl-CoA hydratase
AMETH_5716	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_5717	COG0183	Belongs to the thiolase family
AMETH_5718	COG1309	transcriptional regulator
AMETH_5721	COG1960	acyl-CoA dehydrogenase activity
AMETH_5722	COG1960	acyl-CoA dehydrogenase activity
AMETH_5723	COG0277	FAD linked oxidase domain protein
AMETH_5727	COG0640	Transcriptional regulator
AMETH_5728	COG0346	lactoylglutathione lyase activity
AMETH_5734	COG1191	sigma factor activity
AMETH_5735	COG1960	acyl-CoA dehydrogenase activity
AMETH_5737	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_5744	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMETH_5747	COG2508	Transcriptional regulator
AMETH_5747	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMETH_5753	COG1132	(ABC) transporter
AMETH_5754	COG0277	FAD linked oxidase domain protein
AMETH_5760	COG0567	Dehydrogenase, E1 component
AMETH_5760	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_5763	COG0281	malic enzyme
AMETH_5764	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMETH_5769	COG0406	alpha-ribazole phosphatase activity
AMETH_5770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMETH_5773	COG1597	lipid kinase activity
AMETH_5776	COG5662	AntiSigma factor
AMETH_5778	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMETH_5780	COG2135	peptidase activity
AMETH_5788	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_5789	COG1011	Hydrolase
AMETH_5791	COG0653	protein targeting
AMETH_5792	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AMETH_5794	COG5401	PFAM Sporulation and spore germination
AMETH_5795	COG5000	phosphorelay sensor kinase activity
AMETH_5795	COG5002	protein histidine kinase activity
AMETH_5796	COG0745	RESPONSE REGULATOR receiver
AMETH_5800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMETH_5802	COG0531	amino acid
AMETH_5806	COG1482	cell wall glycoprotein biosynthetic process
AMETH_5808	COG2835	tetraacyldisaccharide 4'-kinase activity
AMETH_5809	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMETH_5814	COG1994	Peptidase M50
AMETH_5817	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_5818	COG0747	negative chemotaxis
AMETH_5822	COG4608	Belongs to the ABC transporter superfamily
AMETH_5823	COG0747	negative chemotaxis
AMETH_5827	COG0180	Tryptophanyl-tRNA synthetase
AMETH_5831	COG0745	RESPONSE REGULATOR receiver
AMETH_5833	COG1131	(ABC) transporter
AMETH_5835	COG3842	ATPase activity
AMETH_5836	COG4149	molybdate abc transporter
AMETH_5838	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMETH_5840	COG0012	GTP binding
AMETH_5843	COG0419	ATPase involved in DNA repair
AMETH_5844	COG0420	3'-5' exonuclease activity
AMETH_5847	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMETH_5849	COG1570	exodeoxyribonuclease VII activity
AMETH_5851	COG1722	exodeoxyribonuclease VII activity
AMETH_5854	COG0492	ferredoxin-NADP+ reductase activity
AMETH_5855	COG0114	fumarate hydratase activity
AMETH_5856	COG0667	Aldo Keto reductase
AMETH_5860	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMETH_5862	COG1793	dna ligase
AMETH_5864	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_5865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_5869	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMETH_5876	COG1331	Highly conserved protein containing a thioredoxin domain
AMETH_5878	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_5880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMETH_5881	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_5883	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AMETH_5885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMETH_5892	COG0183	Belongs to the thiolase family
AMETH_5898	COG0642	Histidine kinase
AMETH_5906	COG3707	response regulator
AMETH_5909	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AMETH_5920	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_5931	COG0582	viral genome integration into host DNA
AMETH_5932	COG1252	NADH dehydrogenase
AMETH_5941	COG0148	phosphopyruvate hydratase activity
AMETH_5945	COG0672	)-iron permease
AMETH_5946	COG2822	iron ion transport
AMETH_5947	COG2837	iron assimilation
AMETH_5948	COG3956	TIGRFAM MazG family protein
AMETH_5952	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_5957	COG2133	pyrroloquinoline quinone binding
AMETH_5958	COG1113	amino acid transport
AMETH_5962	COG2076	Multidrug Resistance protein
AMETH_5965	COG3903	Transcriptional regulator
AMETH_5965	COG3629	intracellular signal transduction
AMETH_5969	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMETH_5974	COG0193	aminoacyl-tRNA hydrolase activity
AMETH_5976	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_5979	COG1309	transcriptional regulator
AMETH_5980	COG0488	(ABC) transporter
AMETH_5981	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMETH_5982	COG1309	transcriptional regulator
AMETH_5984	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMETH_5985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMETH_5986	COG3583	domain protein
AMETH_5987	COG0084	hydrolase, TatD family'
AMETH_5988	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMETH_5995	COG1136	(ABC) transporter
AMETH_5995	COG0577	efflux transmembrane transporter activity
AMETH_6003	COG2226	methyltransferase
AMETH_6010	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_6014	COG2217	Heavy metal translocating P-type atpase
AMETH_6015	COG0640	Transcriptional regulator
AMETH_6019	COG0596	Alpha beta hydrolase
AMETH_6025	COG1349	DNA-binding transcription factor activity
AMETH_6027	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_6029	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMETH_6029	COG1902	pentaerythritol trinitrate reductase activity
AMETH_6030	COG0531	amino acid
AMETH_6032	COG4638	Rieske (2fe-2S)
AMETH_6033	COG3619	membrane
AMETH_6034	COG0477	Major facilitator Superfamily
AMETH_6040	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AMETH_6043	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_6048	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMETH_6053	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMETH_6054	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMETH_6059	COG0315	cyclic pyranopterin monophosphate synthase activity
AMETH_6059	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMETH_6062	COG1349	DNA-binding transcription factor activity
AMETH_6063	COG2205	protein histidine kinase activity
AMETH_6064	COG0745	RESPONSE REGULATOR receiver
AMETH_6065	COG2197	response regulator
AMETH_6082	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_6087	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_6091	COG4191	Histidine kinase
AMETH_6092	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_6093	COG0492	ferredoxin-NADP+ reductase activity
AMETH_6094	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMETH_6095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_6097	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AMETH_6099	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMETH_6100	COG0022	dehydrogenase e1 component
AMETH_6101	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_6104	COG2151	metal-sulfur cluster biosynthetic enzyme
AMETH_6110	COG3350	monooxygenase activity
AMETH_6115	COG2207	Transcriptional regulator
AMETH_6116	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_6117	COG1349	DNA-binding transcription factor activity
AMETH_6118	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_6119	COG1940	carbohydrate kinase activity
AMETH_6123	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_6128	COG1940	carbohydrate kinase activity
AMETH_6132	COG0395	ABC-type sugar transport system, permease component
AMETH_6134	COG1653	transport
AMETH_6135	COG0673	inositol 2-dehydrogenase activity
AMETH_6140	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_6144	COG0387	Pfam Sodium calcium exchanger
AMETH_6146	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_6155	COG0668	transmembrane transport
AMETH_6156	COG1234	tRNA 3'-trailer cleavage
AMETH_6158	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_6159	COG3795	YCII-related domain
AMETH_6160	COG4941	Belongs to the sigma-70 factor family
AMETH_6162	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_6165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_6166	COG2267	carboxylic ester hydrolase activity
AMETH_6168	COG0583	DNA-binding transcription factor activity
AMETH_6169	COG2814	Major facilitator Superfamily
AMETH_6170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMETH_6175	COG0583	DNA-binding transcription factor activity
AMETH_6176	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_6178	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_6179	COG1960	acyl-CoA dehydrogenase activity
AMETH_6180	COG5479	isomerase activity
AMETH_6180	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_6182	COG1064	alcohol dehydrogenase
AMETH_6184	COG1321	iron dependent repressor
AMETH_6190	COG1024	Enoyl-CoA hydratase
AMETH_6191	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_6194	COG1960	acyl-CoA dehydrogenase activity
AMETH_6196	COG2091	lysine biosynthetic process via aminoadipic acid
AMETH_6197	COG1169	isochorismate synthase
AMETH_6199	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_6204	COG4152	abc transporter atp-binding protein
AMETH_6206	COG0415	Belongs to the DNA photolyase family
AMETH_6211	COG1960	acyl-CoA dehydrogenase activity
AMETH_6212	COG1228	amidohydrolase
AMETH_6213	COG2017	converts alpha-aldose to the beta-anomer
AMETH_6214	COG1309	transcriptional regulator
AMETH_6222	COG0259	pyridoxamine-phosphate oxidase activity
AMETH_6223	COG0829	nickel cation binding
AMETH_6224	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AMETH_6225	COG0804	urea catabolic process
AMETH_6226	COG0832	Belongs to the urease beta subunit family
AMETH_6227	COG0831	urea catabolic process
AMETH_6230	COG0251	oxidation-reduction process
AMETH_6231	COG3226	Transcriptional regulator
AMETH_6233	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AMETH_6237	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_6239	COG5398	heme oxygenase
AMETH_6241	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AMETH_6254	COG0789	Transcriptional regulator
AMETH_6292	COG2197	response regulator
AMETH_6298	COG1674	ftsk spoiiie
AMETH_6313	COG0789	Transcriptional regulator
AMETH_6351	COG2197	response regulator
AMETH_6357	COG1674	ftsk spoiiie
AMETH_6364	COG2814	Major facilitator Superfamily
AMETH_6368	COG2252	PERMEase
AMETH_6373	COG2814	Major facilitator Superfamily
AMETH_6375	COG1278	Cold shock
AMETH_6378	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_6379	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_6380	COG0384	phenazine biosynthesis protein PhzF
AMETH_6381	COG3304	Inner membrane component domain
AMETH_6390	COG1846	Transcriptional regulator
AMETH_6393	COG1388	LysM domain
AMETH_6397	COG2169	Transcriptional regulator
AMETH_6402	COG2018	Roadblock/LC7 domain
AMETH_6405	COG2018	Roadblock/LC7 domain
AMETH_6407	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AMETH_6408	COG0765	amino acid transport
AMETH_6412	COG1061	Type III restriction enzyme res subunit
AMETH_6416	COG0693	protein deglycase activity
AMETH_6418	COG1063	alcohol dehydrogenase
AMETH_6419	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_6422	COG0459	protein refolding
AMETH_6424	COG1278	Cold shock
AMETH_6428	COG0688	phosphatidylethanolamine metabolic process
AMETH_6429	COG1183	phosphatidylcholine synthase activity
AMETH_6435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_6438	COG0242	peptide deformylase activity
AMETH_6445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMETH_6449	COG2022	thiamine diphosphate biosynthetic process
AMETH_6451	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMETH_6451	COG2022	thiamine diphosphate biosynthetic process
AMETH_6452	COG0352	thiamine-phosphate diphosphorylase activity
AMETH_6454	COG2188	Transcriptional regulator
AMETH_6455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_6456	COG2971	BadF BadG BcrA BcrD
AMETH_6458	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMETH_6461	COG3629	intracellular signal transduction
AMETH_6461	COG3903	Transcriptional regulator
AMETH_6462	COG5285	phytanoyl-CoA dioxygenase
AMETH_6463	COG1917	Cupin 2, conserved barrel domain protein
AMETH_6465	COG0456	acetyltransferase
AMETH_6470	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMETH_6470	COG1902	pentaerythritol trinitrate reductase activity
AMETH_6473	COG0400	carboxylic ester hydrolase activity
AMETH_6474	COG0346	lactoylglutathione lyase activity
AMETH_6481	COG0129	dihydroxy-acid dehydratase activity
AMETH_6487	COG1921	L-seryl-tRNASec selenium transferase activity
AMETH_6488	COG0709	Synthesizes selenophosphate from selenide and ATP
AMETH_6490	COG1832	CoA-binding protein
AMETH_6491	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_6493	COG0477	Major facilitator Superfamily
AMETH_6501	COG0657	acetylesterase activity
AMETH_6510	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMETH_6511	COG2847	Copper chaperone PCu(A)C
AMETH_6512	COG1329	Transcriptional regulator
AMETH_6513	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMETH_6514	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMETH_6515	COG0546	phosphoglycolate phosphatase activity
AMETH_6516	COG0215	cysteine-tRNA ligase activity
AMETH_6517	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_6521	COG0235	Class ii aldolase
AMETH_6523	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMETH_6524	COG0698	ribose 5-phosphate isomerase
AMETH_6525	COG2376	Dihydroxyacetone kinase
AMETH_6526	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMETH_6527	COG0406	alpha-ribazole phosphatase activity
AMETH_6527	COG0328	RNA-DNA hybrid ribonuclease activity
AMETH_6528	COG1349	DNA-binding transcription factor activity
AMETH_6529	COG2814	Major facilitator Superfamily
AMETH_6530	COG1070	Carbohydrate kinase
AMETH_6532	COG4399	Belongs to the UPF0754 family
AMETH_6533	COG4399	Belongs to the UPF0754 family
AMETH_6535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMETH_6536	COG1121	(ABC) transporter
AMETH_6538	COG1609	Transcriptional regulator
AMETH_6540	COG1194	a g-specific adenine glycosylase
AMETH_6541	COG0667	Aldo Keto reductase
AMETH_6543	COG0596	Alpha beta hydrolase
AMETH_6544	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_6546	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMETH_6549	COG0583	DNA-binding transcription factor activity
AMETH_6554	COG0443	Heat shock 70 kDa protein
AMETH_6555	COG0542	response to heat
AMETH_6561	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMETH_6562	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMETH_6563	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMETH_6568	COG0789	Transcriptional regulator
AMETH_6573	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_6580	COG0037	tRNA processing
AMETH_6583	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMETH_6584	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMETH_6590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMETH_6591	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMETH_6594	COG1754	DNA topoisomerase type I activity
AMETH_6594	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMETH_6597	COG0789	Transcriptional regulator
AMETH_6599	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMETH_6600	COG1111	helicase
AMETH_6600	COG1205	dead DEAH box helicase
AMETH_6610	COG1472	Belongs to the glycosyl hydrolase 3 family
AMETH_6611	COG3876	Protein conserved in bacteria
AMETH_6612	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_6613	COG1737	Transcriptional regulator
AMETH_6614	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AMETH_6616	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AMETH_6617	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_6622	COG0477	Major facilitator Superfamily
AMETH_6624	COG4941	Belongs to the sigma-70 factor family
AMETH_6628	COG3104	oligopeptide transport
AMETH_6629	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AMETH_6631	COG2267	carboxylic ester hydrolase activity
AMETH_6639	COG4221	oxidoreductase activity
AMETH_6649	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMETH_6650	COG1408	metallophosphoesterase
AMETH_6653	COG0076	glutamate decarboxylase activity
AMETH_6654	COG0783	Belongs to the Dps family
AMETH_6655	COG1764	response to oxidative stress
AMETH_6664	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AMETH_6665	COG0667	Aldo Keto reductase
AMETH_6675	COG0583	DNA-binding transcription factor activity
AMETH_6676	COG0697	spore germination
AMETH_6678	COG4608	Belongs to the ABC transporter superfamily
AMETH_6679	COG0444	Belongs to the ABC transporter superfamily
AMETH_6682	COG0747	negative chemotaxis
AMETH_6684	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMETH_6685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMETH_6686	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMETH_6689	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMETH_6691	COG2205	protein histidine kinase activity
AMETH_6692	COG0745	RESPONSE REGULATOR receiver
AMETH_6700	COG1278	Cold shock
AMETH_6704	COG0477	Major facilitator Superfamily
AMETH_6706	COG0515	serine threonine protein kinase
AMETH_6707	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_6721	COG0477	Major facilitator Superfamily
AMETH_6732	COG2391	methyltransferase activity
AMETH_6733	COG0454	-acetyltransferase
AMETH_6735	COG0412	Dienelactone hydrolase
AMETH_6736	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_6737	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_6743	COG1609	Transcriptional regulator
AMETH_6744	COG2814	Major facilitator Superfamily
AMETH_6749	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMETH_6753	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMETH_6761	COG0546	phosphoglycolate phosphatase activity
AMETH_6762	COG2188	Transcriptional regulator
AMETH_6771	COG0717	Belongs to the dCTP deaminase family
AMETH_6774	COG0477	Major facilitator Superfamily
AMETH_6775	COG1960	acyl-CoA dehydrogenase activity
AMETH_6776	COG1309	transcriptional regulator
AMETH_6779	COG0247	lactate metabolic process
AMETH_6779	COG2181	nitrate reductase activity
AMETH_6780	COG2076	Multidrug Resistance protein
AMETH_6782	COG0477	Major facilitator Superfamily
AMETH_6786	COG0443	Heat shock 70 kDa protein
AMETH_6787	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMETH_6788	COG0484	heat shock protein binding
AMETH_6789	COG0789	Transcriptional regulator
AMETH_6790	COG0412	Dienelactone hydrolase
AMETH_6793	COG0477	Major facilitator Superfamily
AMETH_6796	COG0542	response to heat
AMETH_6798	COG4221	oxidoreductase activity
AMETH_6801	COG2318	DinB family
AMETH_6804	COG1053	succinate dehydrogenase
AMETH_6805	COG2223	nitrite transmembrane transporter activity
AMETH_6806	COG0583	DNA-binding transcription factor activity
AMETH_6810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_6811	COG3383	formate dehydrogenase (NAD+) activity
AMETH_6813	COG1609	Transcriptional regulator
AMETH_6818	COG1072	(Pantothenic acid kinase))
AMETH_6819	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_6821	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_6822	COG0586	Pfam SNARE associated Golgi protein
AMETH_6823	COG2353	YceI-like domain
AMETH_6825	COG1846	Transcriptional regulator
AMETH_6826	COG0277	FAD linked oxidase domain protein
AMETH_6828	COG0586	Pfam SNARE associated Golgi protein
AMETH_6834	COG0300	oxidoreductase activity
AMETH_6835	COG0667	Aldo Keto reductase
AMETH_6850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_6851	COG0025	NhaP-type Na H and K H
AMETH_6852	COG0477	Major facilitator Superfamily
AMETH_6853	COG0584	glycerophosphoryl diester phosphodiesterase
AMETH_6860	COG3953	SLT domain
AMETH_6860	COG5280	Phage tail tape measure protein TP901
AMETH_6868	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMETH_6872	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMETH_6875	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_6881	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMETH_6882	COG0047	phosphoribosylformylglycinamidine synthase activity
AMETH_6883	COG1132	(ABC) transporter
AMETH_6884	COG1132	(ABC) transporter
AMETH_6885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMETH_6899	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMETH_6900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMETH_6903	COG2378	regulation of single-species biofilm formation
AMETH_6909	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMETH_6911	COG1984	allophanate hydrolase subunit 2
AMETH_6913	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AMETH_6920	COG0745	RESPONSE REGULATOR receiver
AMETH_6921	COG0456	acetyltransferase
AMETH_6921	COG0454	-acetyltransferase
AMETH_6925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMETH_6927	COG2357	RelA SpoT domain protein
AMETH_6928	COG0704	Plays a role in the regulation of phosphate uptake
AMETH_6931	COG3706	GGDEF domain
AMETH_6931	COG0745	RESPONSE REGULATOR receiver
AMETH_6933	COG4085	toxin activity
AMETH_6933	COG1525	nuclease
AMETH_6933	COG0737	Belongs to the 5'-nucleotidase family
AMETH_6935	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AMETH_6936	COG3663	DNA glycosylase
AMETH_6938	COG2197	response regulator
AMETH_6939	COG1960	acyl-CoA dehydrogenase activity
AMETH_6942	COG0640	Transcriptional regulator
AMETH_6948	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMETH_6954	COG3030	protein affecting phage T7 exclusion by the F plasmid
AMETH_6956	COG1309	transcriptional regulator
AMETH_6957	COG2030	dehydratase
AMETH_6958	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_6959	COG0183	Belongs to the thiolase family
AMETH_6972	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AMETH_6977	COG4585	Histidine kinase
AMETH_6978	COG2197	response regulator
AMETH_6983	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMETH_6987	COG2197	response regulator
AMETH_6989	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_6991	COG0402	S-adenosylhomocysteine deaminase activity
AMETH_6996	COG4221	oxidoreductase activity
AMETH_7000	COG2814	Major facilitator Superfamily
AMETH_7001	COG1846	Transcriptional regulator
AMETH_7003	COG0640	Transcriptional regulator
AMETH_7004	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMETH_7006	COG1695	Transcriptional regulator
AMETH_7008	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMETH_7014	COG0360	Binds together with S18 to 16S ribosomal RNA
AMETH_7016	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMETH_7017	COG0359	binds to the 23S rRNA
AMETH_7023	COG2267	carboxylic ester hydrolase activity
AMETH_7026	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMETH_7028	COG3384	dioxygenase
AMETH_7035	COG2205	protein histidine kinase activity
AMETH_7036	COG2197	response regulator
AMETH_7038	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMETH_7040	COG0495	leucyl-tRNA aminoacylation
AMETH_7043	COG1678	Uncharacterized ACR, COG1678
AMETH_7053	COG4585	Histidine kinase
AMETH_7054	COG0617	tRNA 3'-terminal CCA addition
AMETH_7059	COG1595	DNA-templated transcription, initiation
AMETH_7062	COG0492	ferredoxin-NADP+ reductase activity
AMETH_7062	COG3118	belongs to the thioredoxin family
AMETH_7063	COG3409	Peptidoglycan-binding domain 1 protein
AMETH_7063	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMETH_7066	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMETH_7068	COG1192	Involved in chromosome partitioning
AMETH_7069	COG0357	Ribosomal RNA small subunit methyltransferase G
AMETH_7072	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMETH_7073	COG0594	ribonuclease P activity
AMETH_7074	COG0230	Belongs to the bacterial ribosomal protein bL34 family