locus-tag	class	description
SD37_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SD37_00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SD37_00025	COG0706	membrane insertase activity
SD37_00035	COG0357	Ribosomal RNA small subunit methyltransferase G
SD37_00040	COG1192	Involved in chromosome partitioning
SD37_00055	COG1181	Belongs to the D-alanine--D-alanine ligase family
SD37_00070	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD37_00070	COG3409	Peptidoglycan-binding domain 1 protein
SD37_00075	COG3118	belongs to the thioredoxin family
SD37_00075	COG0492	ferredoxin-NADP+ reductase activity
SD37_00090	COG1595	DNA-templated transcription, initiation
SD37_00120	COG0617	tRNA 3'-terminal CCA addition
SD37_00130	COG4585	Histidine kinase
SD37_00140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_00210	COG0495	leucyl-tRNA aminoacylation
SD37_00215	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_00250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_00255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SD37_00265	COG0477	Major facilitator Superfamily
SD37_00280	COG2197	response regulator
SD37_00305	COG1846	Transcriptional regulator
SD37_00305	COG1940	carbohydrate kinase activity
SD37_00310	COG0738	Major facilitator superfamily
SD37_00315	COG3384	dioxygenase
SD37_00370	COG0359	binds to the 23S rRNA
SD37_00375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SD37_00385	COG0360	Binds together with S18 to 16S ribosomal RNA
SD37_00425	COG1940	carbohydrate kinase activity
SD37_00425	COG1846	Transcriptional regulator
SD37_00430	COG0673	inositol 2-dehydrogenase activity
SD37_00435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_00440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_00450	COG1695	Transcriptional regulator
SD37_00475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_00485	COG2814	Major facilitator Superfamily
SD37_00505	COG2226	methyltransferase
SD37_00510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_00515	COG4221	oxidoreductase activity
SD37_00520	COG0402	S-adenosylhomocysteine deaminase activity
SD37_00525	COG2197	response regulator
SD37_00535	COG1136	(ABC) transporter
SD37_00545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SD37_00580	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_00590	COG2197	response regulator
SD37_00595	COG4585	Histidine kinase
SD37_00630	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SD37_00640	COG4133	protoheme IX ABC transporter activity
SD37_00695	COG0456	acetyltransferase
SD37_00695	COG0454	-acetyltransferase
SD37_00705	COG0789	Transcriptional regulator
SD37_00710	COG0584	glycerophosphoryl diester phosphodiesterase
SD37_00735	COG0183	Belongs to the thiolase family
SD37_00740	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_00745	COG2030	dehydratase
SD37_00750	COG1309	transcriptional regulator
SD37_00770	COG3030	protein affecting phage T7 exclusion by the F plasmid
SD37_00805	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_00810	COG0022	dehydrogenase e1 component
SD37_00820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_00825	COG0596	Alpha beta hydrolase
SD37_00835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_00840	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_00845	COG1305	Transglutaminase-like
SD37_00860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_00865	COG0765	amino acid transport
SD37_00870	COG1126	abc transporter atp-binding protein
SD37_00930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SD37_00955	COG1960	acyl-CoA dehydrogenase activity
SD37_00960	COG2197	response regulator
SD37_00965	COG3663	DNA glycosylase
SD37_00990	COG0737	Belongs to the 5'-nucleotidase family
SD37_01030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SD37_01045	COG0717	Belongs to the dCTP deaminase family
SD37_01055	COG1846	Transcriptional regulator
SD37_01060	COG2340	Cysteine-rich secretory protein family
SD37_01075	COG0247	lactate metabolic process
SD37_01075	COG2181	nitrate reductase activity
SD37_01080	COG2076	Multidrug Resistance protein
SD37_01115	COG0443	Heat shock 70 kDa protein
SD37_01120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SD37_01125	COG0484	heat shock protein binding
SD37_01130	COG0789	Transcriptional regulator
SD37_01165	COG0542	response to heat
SD37_01190	COG0577	efflux transmembrane transporter activity
SD37_01190	COG1136	(ABC) transporter
SD37_01210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_01215	COG0243	molybdopterin cofactor binding
SD37_01230	COG1609	Transcriptional regulator
SD37_01235	COG1609	Transcriptional regulator
SD37_01255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_01260	COG1072	(Pantothenic acid kinase))
SD37_01265	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_01275	COG0586	Pfam SNARE associated Golgi protein
SD37_01280	COG0477	Major facilitator Superfamily
SD37_01290	COG3467	pyridoxamine 5'-phosphate
SD37_01300	COG0477	Major facilitator Superfamily
SD37_01305	COG0277	FAD linked oxidase domain protein
SD37_01310	COG0586	Pfam SNARE associated Golgi protein
SD37_01355	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_01360	COG0667	Aldo Keto reductase
SD37_01425	COG1819	glycosyl
SD37_01430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_01435	COG4172	Belongs to the ABC transporter superfamily
SD37_01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD37_01465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SD37_01480	COG2814	Major facilitator Superfamily
SD37_01490	COG0584	glycerophosphoryl diester phosphodiesterase
SD37_01525	COG3953	SLT domain
SD37_01525	COG5412	phage tail tape measure protein
SD37_01540	COG0436	Aminotransferase
SD37_01580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SD37_01590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_01600	COG0765	amino acid transport
SD37_01605	COG1126	abc transporter atp-binding protein
SD37_01620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SD37_01635	COG2311	Membrane
SD37_01640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SD37_01670	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SD37_01675	COG0047	phosphoribosylformylglycinamidine synthase activity
SD37_01680	COG1132	(ABC) transporter
SD37_01685	COG1132	(ABC) transporter
SD37_01755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SD37_01805	COG0354	folic acid binding
SD37_01820	COG1984	allophanate hydrolase subunit 2
SD37_01830	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SD37_01860	COG0745	RESPONSE REGULATOR receiver
SD37_01885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SD37_01890	COG0704	Plays a role in the regulation of phosphate uptake
SD37_01895	COG1316	TRANSCRIPTIONal
SD37_01900	COG3706	GGDEF domain
SD37_01900	COG0745	RESPONSE REGULATOR receiver
SD37_01905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SD37_01910	COG0596	Alpha beta hydrolase
SD37_01960	COG3973	AAA domain
SD37_02005	COG3237	CsbD-like
SD37_02020	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
SD37_02080	COG5479	isomerase activity
SD37_02080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SD37_02085	COG5479	isomerase activity
SD37_02085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SD37_02090	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_02120	COG2197	response regulator
SD37_02140	COG0745	RESPONSE REGULATOR receiver
SD37_02145	COG2205	protein histidine kinase activity
SD37_02150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_02170	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD37_02175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SD37_02180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SD37_02185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SD37_02190	COG1215	transferase activity, transferring glycosyl groups
SD37_02205	COG0463	Glycosyl transferase, family 2
SD37_02220	COG0747	negative chemotaxis
SD37_02240	COG4608	Belongs to the ABC transporter superfamily
SD37_02255	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_02265	COG0697	spore germination
SD37_02270	COG0583	DNA-binding transcription factor activity
SD37_02305	COG0477	Major facilitator Superfamily
SD37_02330	COG0501	Belongs to the peptidase M48B family
SD37_02335	COG1690	Belongs to the RtcB family
SD37_02345	COG3293	Transposase
SD37_02380	COG1764	response to oxidative stress
SD37_02385	COG0783	Belongs to the Dps family
SD37_02390	COG0076	glutamate decarboxylase activity
SD37_02420	COG1408	metallophosphoesterase
SD37_02425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_02450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SD37_02510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD37_02530	COG0596	Alpha beta hydrolase
SD37_02540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SD37_02545	COG3104	oligopeptide transport
SD37_02585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_02595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SD37_02605	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_02635	COG0640	Transcriptional regulator
SD37_02640	COG2814	Major facilitator Superfamily
SD37_02645	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SD37_02650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SD37_02655	COG1737	Transcriptional regulator
SD37_02660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_02665	COG3876	Protein conserved in bacteria
SD37_02670	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_02720	COG1111	helicase
SD37_02720	COG1205	dead DEAH box helicase
SD37_02725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SD37_02750	COG1754	DNA topoisomerase type I activity
SD37_02750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SD37_02775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SD37_02780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SD37_02805	COG0657	acetylesterase activity
SD37_02810	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_02830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SD37_02835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SD37_02855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SD37_02865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SD37_02870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SD37_02885	COG0037	tRNA processing
SD37_02915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SD37_02920	COG0302	gtp cyclohydrolase
SD37_02925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SD37_02940	COG0789	Transcriptional regulator
SD37_02965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SD37_02970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SD37_02975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SD37_03010	COG0542	response to heat
SD37_03015	COG0443	Heat shock 70 kDa protein
SD37_03020	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SD37_03050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SD37_03065	COG0596	Alpha beta hydrolase
SD37_03070	COG3118	belongs to the thioredoxin family
SD37_03105	COG2814	Major facilitator Superfamily
SD37_03115	COG1194	a g-specific adenine glycosylase
SD37_03125	COG1609	Transcriptional regulator
SD37_03130	COG0803	Belongs to the bacterial solute-binding protein 9 family
SD37_03135	COG1120	ATPase activity
SD37_03155	COG4399	Belongs to the UPF0754 family
SD37_03170	COG0235	Class ii aldolase
SD37_03195	COG1309	transcriptional regulator
SD37_03230	COG0215	cysteine-tRNA ligase activity
SD37_03250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SD37_03255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SD37_03260	COG1329	Transcriptional regulator
SD37_03265	COG2847	Copper chaperone PCu(A)C
SD37_03270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SD37_03300	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SD37_03375	COG0640	Transcriptional regulator
SD37_03395	COG1595	DNA-templated transcription, initiation
SD37_03400	COG0583	DNA-binding transcription factor activity
SD37_03410	COG3795	YCII-related domain
SD37_03415	COG4941	Belongs to the sigma-70 factor family
SD37_03430	COG1620	l-lactate permease
SD37_03440	COG1832	CoA-binding protein
SD37_03485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_03495	COG0346	lactoylglutathione lyase activity
SD37_03500	COG0400	carboxylic ester hydrolase activity
SD37_03510	COG5416	Lipopolysaccharide assembly protein A domain
SD37_03540	COG1733	regulation of RNA biosynthetic process
SD37_03550	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD37_03555	COG0456	acetyltransferase
SD37_03565	COG1917	Cupin 2, conserved barrel domain protein
SD37_03570	COG5285	phytanoyl-CoA dioxygenase
SD37_03575	COG3903	Transcriptional regulator
SD37_03575	COG3629	intracellular signal transduction
SD37_03605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SD37_03615	COG2971	BadF BadG BcrA BcrD
SD37_03620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_03625	COG2188	Transcriptional regulator
SD37_03630	COG0477	Major facilitator Superfamily
SD37_03645	COG0352	thiamine-phosphate diphosphorylase activity
SD37_03660	COG2022	thiamine diphosphate biosynthetic process
SD37_03690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SD37_03700	COG0242	peptide deformylase activity
SD37_03715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SD37_03725	COG0688	phosphatidylethanolamine metabolic process
SD37_03730	COG2261	transglycosylase associated protein
SD37_03760	COG1278	Cold shock
SD37_03770	COG0459	protein refolding
SD37_03790	COG1388	LysM domain
SD37_03790	COG4942	peptidase
SD37_03795	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_03800	COG3629	intracellular signal transduction
SD37_03800	COG3903	Transcriptional regulator
SD37_03815	COG1061	Type III restriction enzyme res subunit
SD37_03835	COG3142	Participates in the control of copper homeostasis
SD37_03845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SD37_03845	COG1116	anion transmembrane transporter activity
SD37_03850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_03855	COG1174	glycine betaine transport
SD37_03875	COG2018	Roadblock/LC7 domain
SD37_03890	COG2018	Roadblock/LC7 domain
SD37_03925	COG0521	Mo-molybdopterin cofactor biosynthetic process
SD37_03935	COG1388	LysM domain
SD37_03950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SD37_03955	COG1846	Transcriptional regulator
SD37_03990	COG3304	Inner membrane component domain
SD37_03995	COG0384	phenazine biosynthesis protein PhzF
SD37_04005	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_04015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SD37_04020	COG1309	transcriptional regulator
SD37_04035	COG1278	Cold shock
SD37_04045	COG2814	Major facilitator Superfamily
SD37_04070	COG2252	PERMEase
SD37_04080	COG2814	Major facilitator Superfamily
SD37_04100	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_04130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_04180	COG2205	protein histidine kinase activity
SD37_04185	COG0745	RESPONSE REGULATOR receiver
SD37_04205	COG0577	efflux transmembrane transporter activity
SD37_04205	COG1136	(ABC) transporter
SD37_04210	COG0577	efflux transmembrane transporter activity
SD37_04210	COG1136	(ABC) transporter
SD37_04215	COG5650	phosphatidylinositol metabolic process
SD37_04240	COG2197	response regulator
SD37_04245	COG4585	Histidine kinase
SD37_04255	COG1131	(ABC) transporter
SD37_04295	COG0831	urea catabolic process
SD37_04300	COG0832	Belongs to the urease beta subunit family
SD37_04305	COG0804	urea catabolic process
SD37_04315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SD37_04320	COG0829	nickel cation binding
SD37_04350	COG0642	Histidine kinase
SD37_04355	COG1116	anion transmembrane transporter activity
SD37_04360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_04365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SD37_04380	COG0259	pyridoxamine-phosphate oxidase activity
SD37_04410	COG1309	transcriptional regulator
SD37_04415	COG1192	Involved in chromosome partitioning
SD37_04425	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_04430	COG2017	converts alpha-aldose to the beta-anomer
SD37_04440	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD37_04450	COG1960	acyl-CoA dehydrogenase activity
SD37_04470	COG0415	Belongs to the DNA photolyase family
SD37_04480	COG4152	abc transporter atp-binding protein
SD37_04515	COG0277	FAD linked oxidase domain protein
SD37_04545	COG0789	Transcriptional regulator
SD37_04585	COG1169	isochorismate synthase
SD37_04595	COG1301	dicarboxylic acid transport
SD37_04600	COG1960	acyl-CoA dehydrogenase activity
SD37_04615	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_04620	COG1024	Enoyl-CoA hydratase
SD37_04625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SD37_04635	COG1321	iron dependent repressor
SD37_04650	COG3145	DNA-N1-methyladenine dioxygenase activity
SD37_04655	COG1984	allophanate hydrolase subunit 2
SD37_04660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SD37_04665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SD37_04670	COG4336	lyase activity
SD37_04690	COG1940	carbohydrate kinase activity
SD37_04730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SD37_04730	COG2755	lipolytic protein G-D-S-L family
SD37_04740	COG0583	DNA-binding transcription factor activity
SD37_04745	COG2264	protein methyltransferase activity
SD37_04760	COG0789	Transcriptional regulator
SD37_04765	COG4941	Belongs to the sigma-70 factor family
SD37_04780	COG1131	(ABC) transporter
SD37_04790	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_04800	COG4221	oxidoreductase activity
SD37_04825	COG3629	intracellular signal transduction
SD37_04825	COG3903	Transcriptional regulator
SD37_04855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SD37_04910	COG2197	response regulator
SD37_04915	COG2860	membrane
SD37_04925	COG2205	protein histidine kinase activity
SD37_04935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SD37_04945	COG1349	DNA-binding transcription factor activity
SD37_04955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD37_04985	COG2372	response to copper ion
SD37_04985	COG1276	copper resistance
SD37_05010	COG3794	PFAM blue (type 1) copper domain protein
SD37_05020	COG0745	RESPONSE REGULATOR receiver
SD37_05025	COG5002	protein histidine kinase activity
SD37_05035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_05040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SD37_05045	COG0521	Mo-molybdopterin cofactor biosynthetic process
SD37_05045	COG0315	cyclic pyranopterin monophosphate synthase activity
SD37_05105	COG0475	glutathione-regulated potassium exporter activity
SD37_05115	COG2223	nitrite transmembrane transporter activity
SD37_05135	COG2124	cytochrome p450
SD37_05140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD37_05150	COG4221	oxidoreductase activity
SD37_05185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_05210	COG0596	Alpha beta hydrolase
SD37_05220	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SD37_05245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_05275	COG2814	Major facilitator Superfamily
SD37_05285	COG0367	asparagine synthase
SD37_05300	COG0697	spore germination
SD37_05320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SD37_05350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_05360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SD37_05365	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SD37_05370	COG2226	methyltransferase
SD37_05375	COG2409	Drug exporters of the RND superfamily
SD37_05425	COG1012	belongs to the aldehyde dehydrogenase family
SD37_05440	COG2258	MOSC domain
SD37_05525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_05530	COG0084	hydrolase, TatD family'
SD37_05545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SD37_05550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SD37_05555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SD37_05560	COG0488	(ABC) transporter
SD37_05565	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_05580	COG0193	aminoacyl-tRNA hydrolase activity
SD37_05610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SD37_05615	COG3706	GGDEF domain
SD37_05615	COG0745	RESPONSE REGULATOR receiver
SD37_05655	COG2133	pyrroloquinoline quinone binding
SD37_05660	COG2197	response regulator
SD37_05665	COG4585	Histidine kinase
SD37_05670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SD37_05675	COG0586	Pfam SNARE associated Golgi protein
SD37_05685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_05710	COG1733	regulation of RNA biosynthetic process
SD37_05715	COG1595	DNA-templated transcription, initiation
SD37_05725	COG1131	(ABC) transporter
SD37_05755	COG2837	iron assimilation
SD37_05765	COG0672	)-iron permease
SD37_05775	COG0492	ferredoxin-NADP+ reductase activity
SD37_05795	COG0148	phosphopyruvate hydratase activity
SD37_05820	COG4166	transmembrane transport
SD37_05825	COG0601	transmembrane transport
SD37_05835	COG0444	Belongs to the ABC transporter superfamily
SD37_05840	COG4608	Belongs to the ABC transporter superfamily
SD37_05845	COG1404	Belongs to the peptidase S8 family
SD37_05860	COG1515	deoxyribonuclease V activity
SD37_05870	COG1252	NADH dehydrogenase
SD37_05890	COG0745	RESPONSE REGULATOR receiver
SD37_05905	COG2197	response regulator
SD37_05910	COG4585	Histidine kinase
SD37_05935	COG0406	alpha-ribazole phosphatase activity
SD37_05940	COG2124	cytochrome p450
SD37_05955	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_05965	COG1902	pentaerythritol trinitrate reductase activity
SD37_06010	COG2391	methyltransferase activity
SD37_06015	COG0477	Major facilitator Superfamily
SD37_06020	COG0183	Belongs to the thiolase family
SD37_06060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_06095	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SD37_06105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_06110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SD37_06120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD37_06130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SD37_06140	COG1331	Highly conserved protein containing a thioredoxin domain
SD37_06165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SD37_06195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SD37_06250	COG1793	dna ligase
SD37_06275	COG0114	fumarate hydratase activity
SD37_06280	COG0492	ferredoxin-NADP+ reductase activity
SD37_06295	COG1722	exodeoxyribonuclease VII activity
SD37_06305	COG1570	exodeoxyribonuclease VII activity
SD37_06315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SD37_06330	COG0420	3'-5' exonuclease activity
SD37_06335	COG0419	ATPase involved in DNA repair
SD37_06350	COG0012	GTP binding
SD37_06360	COG2234	aminopeptidase activity
SD37_06380	COG3654	unkown
SD37_06390	COG2154	pterin-4-alpha-carbinolamine dehydratase
SD37_06400	COG4149	molybdate abc transporter
SD37_06405	COG3842	ATPase activity
SD37_06415	COG1131	(ABC) transporter
SD37_06440	COG0180	Tryptophanyl-tRNA synthetase
SD37_06455	COG0477	Major facilitator Superfamily
SD37_06460	COG0747	negative chemotaxis
SD37_06470	COG0601	transmembrane transport
SD37_06485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD37_06500	COG1994	Peptidase M50
SD37_06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD37_06530	COG2835	tetraacyldisaccharide 4'-kinase activity
SD37_06540	COG1482	cell wall glycoprotein biosynthetic process
SD37_06550	COG3903	Transcriptional regulator
SD37_06550	COG3629	intracellular signal transduction
SD37_06560	COG0531	amino acid
SD37_06575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SD37_06600	COG4638	Rieske (2fe-2S)
SD37_06605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_06615	COG1414	Transcriptional regulator
SD37_06620	COG2146	nitrite reductase [NAD(P)H] activity
SD37_06630	COG0745	RESPONSE REGULATOR receiver
SD37_06635	COG5002	protein histidine kinase activity
SD37_06635	COG5000	phosphorelay sensor kinase activity
SD37_06650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SD37_06655	COG0653	protein targeting
SD37_06665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_06670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_06705	COG1162	GTPase activity
SD37_06710	COG2135	peptidase activity
SD37_06725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SD37_06750	COG1597	lipid kinase activity
SD37_06765	COG0406	alpha-ribazole phosphatase activity
SD37_06785	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SD37_06790	COG0281	malic enzyme
SD37_06800	COG0517	IMP dehydrogenase activity
SD37_06800	COG1125	glycine betaine transport
SD37_06810	COG1174	glycine betaine transport
SD37_06820	COG3153	acetyltransferase
SD37_06825	COG1404	Belongs to the peptidase S8 family
SD37_06840	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_06840	COG0567	Dehydrogenase, E1 component
SD37_06855	COG1132	(ABC) transporter
SD37_06870	COG0686	Belongs to the AlaDH PNT family
SD37_06890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_06890	COG2508	Transcriptional regulator
SD37_06900	COG1695	Transcriptional regulator
SD37_06905	COG0346	lactoylglutathione lyase activity
SD37_06915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_06930	COG2755	lipolytic protein G-D-S-L family
SD37_06935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_06945	COG1960	acyl-CoA dehydrogenase activity
SD37_06960	COG4221	oxidoreductase activity
SD37_06975	COG1960	acyl-CoA dehydrogenase activity
SD37_06995	COG0183	Belongs to the thiolase family
SD37_07000	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_07000	COG1024	Enoyl-CoA hydratase
SD37_07015	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_07025	COG0477	Major facilitator Superfamily
SD37_07030	COG0028	Belongs to the TPP enzyme family
SD37_07045	COG3903	Transcriptional regulator
SD37_07045	COG3629	intracellular signal transduction
SD37_07070	COG0473	3-isopropylmalate dehydrogenase activity
SD37_07100	COG0154	amidase activity
SD37_07115	COG0667	Aldo Keto reductase
SD37_07135	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SD37_07145	COG2133	pyrroloquinoline quinone binding
SD37_07155	COG0435	Glutathione S-transferase
SD37_07195	COG3345	alpha-galactosidase
SD37_07200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD37_07250	COG2910	NAD(P)H-binding
SD37_07260	COG3795	YCII-related domain
SD37_07275	COG4941	Belongs to the sigma-70 factor family
SD37_07295	COG1169	isochorismate synthase
SD37_07320	COG4171	peptide transport system, permease
SD37_07330	COG3433	isochorismatase activity
SD37_07330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_07330	COG2226	methyltransferase
SD37_07355	COG1021	2,3-dihydroxybenzoate-AMP ligase
SD37_07365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_07375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_07380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_07395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SD37_07400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SD37_07405	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_07455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_07470	COG0596	Alpha beta hydrolase
SD37_07490	COG0018	arginyl-trna synthetase
SD37_07495	COG0019	diaminopimelate decarboxylase activity
SD37_07500	COG0460	homoserine dehydrogenase
SD37_07505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SD37_07510	COG0083	homoserine kinase activity
SD37_07525	COG0254	rRNA binding
SD37_07530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SD37_07555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_07565	COG0596	Alpha beta hydrolase
SD37_07570	COG0789	Transcriptional regulator
SD37_07575	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SD37_07580	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_07595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SD37_07605	COG0356	it plays a direct role in the translocation of protons across the membrane
SD37_07610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SD37_07615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SD37_07620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SD37_07625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SD37_07630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SD37_07635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SD37_07640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SD37_07650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SD37_07665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SD37_07680	COG1280	lysine exporter protein (LysE YggA)
SD37_07685	COG1280	lysine exporter protein (LysE YggA)
SD37_07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_07705	COG0765	amino acid transport
SD37_07710	COG0765	amino acid transport
SD37_07715	COG1126	abc transporter atp-binding protein
SD37_07720	COG1335	isochorismatase
SD37_07725	COG4977	sequence-specific DNA binding
SD37_07740	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SD37_07745	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD37_07770	COG2376	Dihydroxyacetone kinase
SD37_07775	COG1461	Dihydroxyacetone kinase
SD37_07805	COG1522	sequence-specific DNA binding
SD37_07810	COG0626	cystathionine gamma-synthase activity
SD37_07835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SD37_07860	COG1819	glycosyl
SD37_07870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SD37_07875	COG3830	Belongs to the UPF0237 family
SD37_07875	COG0560	Phosphoserine phosphatase
SD37_07900	COG1268	BioY protein
SD37_07910	COG0800	Aldolase
SD37_07915	COG1335	isochorismatase
SD37_07920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SD37_07935	COG3191	aminopeptidase activity
SD37_07955	COG1794	racemase activity, acting on amino acids and derivatives
SD37_07970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SD37_07980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SD37_07985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SD37_08030	COG4585	Histidine kinase
SD37_08035	COG2197	response regulator
SD37_08070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SD37_08140	COG1316	TRANSCRIPTIONal
SD37_08150	COG3706	GGDEF domain
SD37_08160	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_08180	COG3844	kynureninase activity
SD37_08195	COG2018	Roadblock/LC7 domain
SD37_08210	COG2259	Doxx family
SD37_08215	COG2259	Doxx family
SD37_08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_08255	COG1408	metallophosphoesterase
SD37_08265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD37_08270	COG1309	transcriptional regulator
SD37_08305	COG3469	chitinase activity
SD37_08315	COG0698	ribose 5-phosphate isomerase
SD37_08340	COG2267	carboxylic ester hydrolase activity
SD37_08345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SD37_08355	COG2814	Major facilitator Superfamily
SD37_08395	COG0673	inositol 2-dehydrogenase activity
SD37_08405	COG1309	transcriptional regulator
SD37_08410	COG1024	Enoyl-CoA hydratase
SD37_08425	COG2318	DinB family
SD37_08460	COG2197	response regulator
SD37_08465	COG1404	Belongs to the peptidase S8 family
SD37_08485	COG0531	amino acid
SD37_08510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SD37_08515	COG0433	COG0433 Predicted ATPase
SD37_08525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD37_08535	COG2226	methyltransferase
SD37_08540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SD37_08550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SD37_08555	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_08590	COG0183	Belongs to the thiolase family
SD37_08615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_08620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_08630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_08640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_08650	COG3279	Response regulator of the LytR AlgR family
SD37_08655	COG3275	phosphorelay sensor kinase activity
SD37_08685	COG1609	Transcriptional regulator
SD37_08695	COG3537	Alpha-1,2-mannosidase
SD37_08705	COG1846	Transcriptional regulator
SD37_08730	COG0058	SHG alpha-glucan phosphorylase activity
SD37_08750	COG1119	ATPase activity
SD37_08755	COG1024	Enoyl-CoA hydratase
SD37_08760	COG2226	methyltransferase
SD37_08840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SD37_08875	COG3883	PFAM NLP P60 protein
SD37_08875	COG0791	NLP P60 protein
SD37_08880	COG1957	nucleoside hydrolase
SD37_08885	COG0110	maltose O-acetyltransferase activity
SD37_08925	COG3250	beta-galactosidase activity
SD37_08940	COG0386	Belongs to the glutathione peroxidase family
SD37_08950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_08960	COG1307	EDD domain protein, DegV family
SD37_08970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SD37_08990	COG2909	trisaccharide binding
SD37_08995	COG0477	Major facilitator Superfamily
SD37_09005	COG0482	sulfurtransferase activity
SD37_09010	COG0456	acetyltransferase
SD37_09015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_09035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SD37_09055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SD37_09060	COG0154	amidase activity
SD37_09100	COG0129	dihydroxy-acid dehydratase activity
SD37_09115	COG0440	acetolactate synthase activity
SD37_09120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SD37_09170	COG1404	Belongs to the peptidase S8 family
SD37_09175	COG0473	3-isopropylmalate dehydrogenase activity
SD37_09180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SD37_09185	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_09270	COG0667	Aldo Keto reductase
SD37_09275	COG2050	protein possibly involved in aromatic compounds catabolism
SD37_09295	COG2175	clavaminate synthase activity
SD37_09305	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_09330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_09345	COG2867	negative regulation of translational initiation
SD37_09390	COG0745	RESPONSE REGULATOR receiver
SD37_09395	COG2197	response regulator
SD37_09410	COG1228	amidohydrolase
SD37_09415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_09435	COG1522	sequence-specific DNA binding
SD37_09440	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_09440	COG1024	Enoyl-CoA hydratase
SD37_09445	COG0183	Belongs to the thiolase family
SD37_09450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SD37_09470	COG1960	acyl-CoA dehydrogenase activity
SD37_09480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_09485	COG1024	Enoyl-CoA hydratase
SD37_09490	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_09510	COG0747	negative chemotaxis
SD37_09520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD37_09530	COG4608	Belongs to the ABC transporter superfamily
SD37_09545	COG2197	response regulator
SD37_09560	COG2409	Drug exporters of the RND superfamily
SD37_09565	COG2205	protein histidine kinase activity
SD37_09570	COG0745	RESPONSE REGULATOR receiver
SD37_09575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SD37_09585	COG1301	dicarboxylic acid transport
SD37_09590	COG0439	Biotin carboxylase
SD37_09600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_09615	COG0464	growth
SD37_09655	COG1404	Belongs to the peptidase S8 family
SD37_09660	COG1674	ftsk spoiiie
SD37_09670	COG2124	cytochrome p450
SD37_09675	COG2197	response regulator
SD37_09680	COG2124	cytochrome p450
SD37_09685	COG0667	Aldo Keto reductase
SD37_09700	COG2986	histidine ammonia-lyase
SD37_09780	COG2318	DinB family
SD37_09790	COG0667	Aldo Keto reductase
SD37_09795	COG0300	oxidoreductase activity
SD37_09815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_09830	COG1280	lysine exporter protein (LysE YggA)
SD37_09870	COG3483	tryptophan 2,3-dioxygenase activity
SD37_09875	COG0076	glutamate decarboxylase activity
SD37_09890	COG0697	spore germination
SD37_09905	COG2130	NADP-dependent
SD37_09910	COG0583	DNA-binding transcription factor activity
SD37_09920	COG2205	protein histidine kinase activity
SD37_09945	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_09950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SD37_09975	COG3629	intracellular signal transduction
SD37_09975	COG3903	Transcriptional regulator
SD37_09995	COG1063	alcohol dehydrogenase
SD37_10010	COG2197	response regulator
SD37_10020	COG1175	transmembrane transport
SD37_10035	COG3903	Transcriptional regulator
SD37_10035	COG3629	intracellular signal transduction
SD37_10040	COG3903	Transcriptional regulator
SD37_10040	COG3629	intracellular signal transduction
SD37_10060	COG2197	response regulator
SD37_10075	COG1113	amino acid transport
SD37_10115	COG1169	isochorismate synthase
SD37_10130	COG0747	negative chemotaxis
SD37_10140	COG4171	peptide transport system, permease
SD37_10145	COG4172	Belongs to the ABC transporter superfamily
SD37_10150	COG2226	methyltransferase
SD37_10150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_10150	COG3433	isochorismatase activity
SD37_10175	COG0367	asparagine synthase
SD37_10180	COG2124	cytochrome p450
SD37_10185	COG1021	2,3-dihydroxybenzoate-AMP ligase
SD37_10190	COG3433	isochorismatase activity
SD37_10190	COG2226	methyltransferase
SD37_10190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_10230	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_10235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SD37_10245	COG2986	histidine ammonia-lyase
SD37_10260	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_10265	COG2197	response regulator
SD37_10270	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_10270	COG0604	alcohol dehydrogenase
SD37_10270	COG3321	synthase
SD37_10280	COG2197	response regulator
SD37_10295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SD37_10310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SD37_10315	COG1278	Cold shock
SD37_10355	COG3883	PFAM NLP P60 protein
SD37_10355	COG0791	NLP P60 protein
SD37_10390	COG2132	Multicopper oxidase
SD37_10400	COG3246	L-lysine catabolic process to acetate
SD37_10415	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_10420	COG0402	S-adenosylhomocysteine deaminase activity
SD37_10425	COG2072	flavoprotein involved in K transport
SD37_10430	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_10430	COG3321	synthase
SD37_10430	COG0604	alcohol dehydrogenase
SD37_10440	COG2124	cytochrome p450
SD37_10470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_10475	COG1960	acyl-CoA dehydrogenase activity
SD37_10490	COG0446	pyridine nucleotide-disulphide oxidoreductase
SD37_10490	COG1902	pentaerythritol trinitrate reductase activity
SD37_10495	COG0504	CTP synthase activity
SD37_10505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SD37_10510	COG3956	TIGRFAM MazG family protein
SD37_10540	COG3903	Transcriptional regulator
SD37_10540	COG3629	intracellular signal transduction
SD37_10575	COG1051	belongs to the nudix hydrolase family
SD37_10585	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_10585	COG0300	oxidoreductase activity
SD37_10585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_10585	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_10585	COG3321	synthase
SD37_10595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SD37_10620	COG2030	dehydratase
SD37_10625	COG0477	Major facilitator Superfamily
SD37_10635	COG0477	Major facilitator Superfamily
SD37_10650	COG0183	Belongs to the thiolase family
SD37_10660	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_10760	COG0145	ligase activity
SD37_10835	COG0601	transmembrane transport
SD37_10840	COG0444	Belongs to the ABC transporter superfamily
SD37_10865	COG1819	glycosyl
SD37_10875	COG1132	(ABC) transporter
SD37_10900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD37_10905	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_10935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD37_10950	COG0546	phosphoglycolate phosphatase activity
SD37_10990	COG0475	glutathione-regulated potassium exporter activity
SD37_11020	COG0367	asparagine synthase
SD37_11030	COG3239	Fatty acid desaturase
SD37_11055	COG1013	pyruvate-flavodoxin oxidoreductase activity
SD37_11065	COG2076	Multidrug Resistance protein
SD37_11140	COG3629	intracellular signal transduction
SD37_11140	COG3903	Transcriptional regulator
SD37_11145	COG0464	growth
SD37_11150	COG1404	Belongs to the peptidase S8 family
SD37_11155	COG1674	ftsk spoiiie
SD37_11165	COG3266	domain, Protein
SD37_11225	COG3629	intracellular signal transduction
SD37_11225	COG3903	Transcriptional regulator
SD37_11280	COG2508	Transcriptional regulator
SD37_11285	COG2072	flavoprotein involved in K transport
SD37_11315	COG2223	nitrite transmembrane transporter activity
SD37_11320	COG2207	Transcriptional regulator
SD37_11330	COG3629	intracellular signal transduction
SD37_11330	COG3903	Transcriptional regulator
SD37_11350	COG2133	pyrroloquinoline quinone binding
SD37_11360	COG0137	argininosuccinate synthase activity
SD37_11420	COG3850	Histidine kinase
SD37_11420	COG5002	protein histidine kinase activity
SD37_11520	COG2197	response regulator
SD37_11900	COG1672	PFAM Archaeal ATPase
SD37_11900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_11950	COG0300	oxidoreductase activity
SD37_11955	COG1316	TRANSCRIPTIONal
SD37_11965	COG1960	acyl-CoA dehydrogenase activity
SD37_11970	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_11980	COG1024	Enoyl-CoA hydratase
SD37_11985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_11990	COG0583	DNA-binding transcription factor activity
SD37_11995	COG5002	protein histidine kinase activity
SD37_12000	COG0745	RESPONSE REGULATOR receiver
SD37_12010	COG2936	dipeptidyl-peptidase activity
SD37_12025	COG1733	regulation of RNA biosynthetic process
SD37_12030	COG2197	response regulator
SD37_12035	COG3851	Histidine kinase
SD37_12085	COG0779	Required for maturation of 30S ribosomal subunits
SD37_12125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SD37_12145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SD37_12165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SD37_12170	COG1185	polyribonucleotide nucleotidyltransferase activity
SD37_12175	COG0612	Peptidase, M16
SD37_12180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SD37_12200	COG3214	Protein conserved in bacteria
SD37_12230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_12235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SD37_12245	COG1113	amino acid transport
SD37_12275	COG0655	NAD(P)H dehydrogenase (quinone) activity
SD37_12285	COG1674	ftsk spoiiie
SD37_12305	COG0778	Nitroreductase
SD37_12310	COG0596	Alpha beta hydrolase
SD37_12320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SD37_12325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SD37_12335	COG1546	Belongs to the CinA family
SD37_12335	COG1058	Belongs to the CinA family
SD37_12340	COG1396	sequence-specific DNA binding
SD37_12350	COG1595	DNA-templated transcription, initiation
SD37_12365	COG0154	amidase activity
SD37_12370	COG0167	dihydroorotate dehydrogenase activity
SD37_12380	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SD37_12385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD37_12390	COG1192	Involved in chromosome partitioning
SD37_12395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_12400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SD37_12410	COG1305	Transglutaminase-like
SD37_12420	COG0714	Associated with various cellular activities
SD37_12470	COG2001	Belongs to the MraZ family
SD37_12475	COG0275	rRNA processing
SD37_12485	COG0768	penicillin binding
SD37_12500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SD37_12505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SD37_12515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SD37_12520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SD37_12525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SD37_12650	COG0242	peptide deformylase activity
SD37_12655	COG1201	RNA secondary structure unwinding
SD37_12660	COG0443	Heat shock 70 kDa protein
SD37_12670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SD37_12675	COG2137	regulation of response to DNA damage stimulus
SD37_12695	COG0800	Aldolase
SD37_12715	COG1053	succinate dehydrogenase
SD37_12725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_12735	COG0765	amino acid transport
SD37_12740	COG0765	amino acid transport
SD37_12745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_12750	COG1126	abc transporter atp-binding protein
SD37_12755	COG0745	RESPONSE REGULATOR receiver
SD37_12770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SD37_12785	COG1196	nuclear chromosome segregation
SD37_12795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SD37_12815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SD37_12825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SD37_12835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SD37_12875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SD37_12880	COG2076	Multidrug Resistance protein
SD37_12885	COG1505	serine-type exopeptidase activity
SD37_12905	COG3387	PFAM Glycoside hydrolase 15-related
SD37_12920	COG0628	permease
SD37_12935	COG2197	response regulator
SD37_12945	COG2936	dipeptidyl-peptidase activity
SD37_12965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SD37_12980	COG0123	including yeast histone deacetylase and acetoin utilization protein
SD37_12995	COG1309	transcriptional regulator
SD37_13000	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_13005	COG1960	acyl-CoA dehydrogenase activity
SD37_13010	COG1960	acyl-CoA dehydrogenase activity
SD37_13020	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_13030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_13035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_13085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_13125	COG0003	Pfam Anion-transporting ATPase
SD37_13135	COG1940	carbohydrate kinase activity
SD37_13140	COG0494	nUDIX hydrolase
SD37_13145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_13170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SD37_13180	COG1228	amidohydrolase
SD37_13200	COG0640	Transcriptional regulator
SD37_13220	COG1946	Acyl-CoA thioesterase
SD37_13240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_13240	COG1672	PFAM Archaeal ATPase
SD37_13245	COG1012	belongs to the aldehyde dehydrogenase family
SD37_13265	COG1960	acyl-CoA dehydrogenase activity
SD37_13270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_13280	COG1024	Enoyl-CoA hydratase
SD37_13295	COG1566	PFAM secretion protein HlyD family protein
SD37_13300	COG2814	Major facilitator Superfamily
SD37_13315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_13330	COG2018	Roadblock/LC7 domain
SD37_13360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SD37_13360	COG1703	isobutyryl-CoA mutase activity
SD37_13360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SD37_13370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_13375	COG1309	transcriptional regulator
SD37_13380	COG1960	acyl-CoA dehydrogenase activity
SD37_13385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD37_13420	COG1960	acyl-CoA dehydrogenase activity
SD37_13445	COG0196	riboflavin kinase activity
SD37_13475	COG1053	succinate dehydrogenase
SD37_13485	COG1960	acyl-CoA dehydrogenase activity
SD37_13490	COG2267	carboxylic ester hydrolase activity
SD37_13495	COG0346	lactoylglutathione lyase activity
SD37_13500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SD37_13530	COG1960	acyl-CoA dehydrogenase activity
SD37_13535	COG1960	acyl-CoA dehydrogenase activity
SD37_13540	COG1960	acyl-CoA dehydrogenase activity
SD37_13545	COG1024	Enoyl-CoA hydratase
SD37_13550	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_13555	COG1960	acyl-CoA dehydrogenase activity
SD37_13560	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_13565	COG1309	transcriptional regulator
SD37_13570	COG0183	Belongs to the thiolase family
SD37_13575	COG2814	Major facilitator Superfamily
SD37_13585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_13625	COG0110	maltose O-acetyltransferase activity
SD37_13640	COG0596	Alpha beta hydrolase
SD37_13660	COG1024	Enoyl-CoA hydratase
SD37_13670	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_13690	COG0183	Belongs to the thiolase family
SD37_13695	COG2124	cytochrome p450
SD37_13705	COG1295	ribonuclease BN
SD37_13740	COG2070	2-Nitropropane dioxygenase
SD37_13755	COG2188	Transcriptional regulator
SD37_13760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_13800	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SD37_13800	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SD37_13810	COG1490	D-aminoacyl-tRNA deacylase activity
SD37_13815	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_13820	COG1473	amidohydrolase
SD37_13840	COG2313	pseudouridylate synthase activity
SD37_13865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SD37_13880	COG4213	ABC transporter substrate-binding protein
SD37_13890	COG4214	carbohydrate transport
SD37_13900	COG1309	transcriptional regulator
SD37_13925	COG0531	amino acid
SD37_13930	COG2197	response regulator
SD37_13975	COG2826	transposase and inactivated derivatives, IS30 family
SD37_13995	COG0483	inositol monophosphate 1-phosphatase activity
SD37_14015	COG0756	dUTP diphosphatase activity
SD37_14045	COG0569	domain protein
SD37_14050	COG0531	amino acid
SD37_14055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SD37_14085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SD37_14095	COG1309	transcriptional regulator
SD37_14100	COG0300	oxidoreductase activity
SD37_14110	COG1012	belongs to the aldehyde dehydrogenase family
SD37_14125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_14135	COG0745	RESPONSE REGULATOR receiver
SD37_14140	COG2205	protein histidine kinase activity
SD37_14145	COG0656	L-ascorbic acid biosynthetic process
SD37_14165	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_14165	COG1024	Enoyl-CoA hydratase
SD37_14170	COG0183	Belongs to the thiolase family
SD37_14175	COG2367	Beta-lactamase
SD37_14210	COG3665	Urea carboxylase-associated protein
SD37_14220	COG0531	amino acid
SD37_14235	COG2197	response regulator
SD37_14245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SD37_14260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_14270	COG3220	belongs to the UPF0276 family
SD37_14285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SD37_14295	COG2815	serine threonine protein kinase
SD37_14295	COG0515	serine threonine protein kinase
SD37_14305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_14325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_14330	COG0539	negative regulation of cytoplasmic translation
SD37_14335	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_14335	COG2508	Transcriptional regulator
SD37_14340	COG1012	belongs to the aldehyde dehydrogenase family
SD37_14345	COG0506	proline dehydrogenase activity
SD37_14350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD37_14365	COG1793	dna ligase
SD37_14410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SD37_14420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_14430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD37_14450	COG1252	NADH dehydrogenase
SD37_14460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SD37_14465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SD37_14490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SD37_14550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SD37_14565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SD37_14570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SD37_14600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD37_14610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD37_14615	COG1263	PTS System
SD37_14615	COG2190	(PTS) system
SD37_14615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD37_14625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD37_14625	COG1263	PTS System
SD37_14660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SD37_14665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SD37_14675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SD37_14680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD37_14685	COG0346	lactoylglutathione lyase activity
SD37_14700	COG0006	proline dipeptidase activity
SD37_14705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SD37_14710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SD37_14720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SD37_14725	COG0540	Belongs to the ATCase OTCase family
SD37_14740	COG0505	Belongs to the CarA family
SD37_14750	COG0284	orotidine-5'-phosphate decarboxylase activity
SD37_14760	COG0194	GDP metabolic process
SD37_14765	COG1758	RNA polymerase activity
SD37_14775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SD37_14780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SD37_14790	COG0405	Gamma-glutamyltransferase
SD37_14795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SD37_14815	COG2197	response regulator
SD37_14820	COG4585	Histidine kinase
SD37_14835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_14835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_14840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SD37_14860	COG0322	excinuclease ABC activity
SD37_14865	COG1660	Displays ATPase and GTPase activities
SD37_14875	COG1481	regulation of sporulation
SD37_14890	COG0463	Glycosyl transferase, family 2
SD37_14900	COG1309	transcriptional regulator
SD37_14910	COG3250	beta-galactosidase activity
SD37_14960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SD37_14965	COG0126	phosphoglycerate kinase activity
SD37_14970	COG0149	triose-phosphate isomerase activity
SD37_14995	COG0363	glucosamine-6-phosphate deaminase activity
SD37_15010	COG0166	Belongs to the GPI family
SD37_15015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SD37_15025	COG0109	protoheme IX farnesyltransferase activity
SD37_15065	COG1612	heme a metabolic process
SD37_15100	COG0396	ATPase activity
SD37_15150	COG2197	response regulator
SD37_15195	COG2199	diguanylate cyclase activity
SD37_15195	COG2200	EAL domain
SD37_15220	COG0488	(ABC) transporter
SD37_15235	COG1132	(ABC) transporter
SD37_15245	COG4821	SIS domain
SD37_15255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_15260	COG1316	TRANSCRIPTIONal
SD37_15285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SD37_15295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SD37_15295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SD37_15305	COG1024	Enoyl-CoA hydratase
SD37_15335	COG1960	acyl-CoA dehydrogenase activity
SD37_15340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_15360	COG1309	transcriptional regulator
SD37_15385	COG3469	chitinase activity
SD37_15390	COG3706	GGDEF domain
SD37_15390	COG0745	RESPONSE REGULATOR receiver
SD37_15405	COG0477	Major facilitator Superfamily
SD37_15415	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_15435	COG1024	Enoyl-CoA hydratase
SD37_15440	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_15445	COG1309	transcriptional regulator
SD37_15455	COG1960	acyl-CoA dehydrogenase activity
SD37_15460	COG1960	acyl-CoA dehydrogenase activity
SD37_15465	COG1960	acyl-CoA dehydrogenase activity
SD37_15500	COG0484	heat shock protein binding
SD37_15520	COG0531	amino acid
SD37_15525	COG1940	carbohydrate kinase activity
SD37_15530	COG0431	NADPH-dependent FMN reductase
SD37_15550	COG2124	cytochrome p450
SD37_15565	COG2267	carboxylic ester hydrolase activity
SD37_15575	COG0564	pseudouridine synthase activity
SD37_15590	COG1846	Transcriptional regulator
SD37_15605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_15610	COG0477	Major facilitator Superfamily
SD37_15620	COG1793	dna ligase
SD37_15645	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SD37_15670	COG0739	heme binding
SD37_15685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_15685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_15700	COG2814	Major facilitator Superfamily
SD37_15705	COG2855	membrane
SD37_15715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SD37_15725	COG0439	Biotin carboxylase
SD37_15735	COG3706	GGDEF domain
SD37_15775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SD37_15780	COG0328	RNA-DNA hybrid ribonuclease activity
SD37_15795	COG2205	protein histidine kinase activity
SD37_15800	COG0745	RESPONSE REGULATOR receiver
SD37_15810	COG3706	GGDEF domain
SD37_15820	COG3629	intracellular signal transduction
SD37_15820	COG3903	Transcriptional regulator
SD37_15825	COG0697	spore germination
SD37_15860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_15880	COG1733	regulation of RNA biosynthetic process
SD37_15890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_15895	COG1053	succinate dehydrogenase
SD37_15905	COG0154	amidase activity
SD37_15910	COG1414	Transcriptional regulator
SD37_15925	COG2124	cytochrome p450
SD37_15940	COG1733	regulation of RNA biosynthetic process
SD37_15945	COG1309	transcriptional regulator
SD37_15950	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_15955	COG0028	Belongs to the TPP enzyme family
SD37_16015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_16025	COG1573	uracil-dna glycosylase
SD37_16035	COG3655	Transcriptional regulator
SD37_16065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_16065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_16095	COG0017	Asparaginyl-tRNA synthetase
SD37_16100	COG0069	glutamate synthase activity
SD37_16110	COG2826	transposase and inactivated derivatives, IS30 family
SD37_16140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SD37_16145	COG1834	amidinotransferase
SD37_16150	COG0475	glutathione-regulated potassium exporter activity
SD37_16160	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_16205	COG0704	Plays a role in the regulation of phosphate uptake
SD37_16230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD37_16240	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_16245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SD37_16245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SD37_16250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SD37_16255	COG2192	nodulation
SD37_16260	COG1088	dTDP-glucose 4,6-dehydratase activity
SD37_16280	COG0438	transferase activity, transferring glycosyl groups
SD37_16295	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_16310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_16315	COG0723	plastoquinol--plastocyanin reductase activity
SD37_16340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_16355	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_16360	COG3835	regulator
SD37_16370	COG3629	intracellular signal transduction
SD37_16370	COG3903	Transcriptional regulator
SD37_16380	COG0515	serine threonine protein kinase
SD37_16410	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SD37_16475	COG1120	ATPase activity
SD37_16480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD37_16535	COG1609	Transcriptional regulator
SD37_16540	COG1129	ABC transporter
SD37_16545	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_16550	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_16565	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_16565	COG3347	Dehydrogenase
SD37_16570	COG1070	Carbohydrate kinase
SD37_16595	COG2267	carboxylic ester hydrolase activity
SD37_16635	COG1131	(ABC) transporter
SD37_16640	COG1132	(ABC) transporter
SD37_16655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_16680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_16685	COG2197	response regulator
SD37_16690	COG4585	Histidine kinase
SD37_16700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_16715	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_16730	COG1716	ATPase activity
SD37_16745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_16775	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SD37_16805	COG0673	inositol 2-dehydrogenase activity
SD37_16820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD37_16855	COG0175	sulfate reduction
SD37_16860	COG2895	sulfate adenylyltransferase (ATP) activity
SD37_16910	COG3903	Transcriptional regulator
SD37_16910	COG3629	intracellular signal transduction
SD37_16920	COG2318	DinB family
SD37_16925	COG0527	aspartate kinase activity
SD37_16940	COG2226	methyltransferase
SD37_16975	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_16975	COG0300	oxidoreductase activity
SD37_16975	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_16975	COG3321	synthase
SD37_16975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_17025	COG0583	DNA-binding transcription factor activity
SD37_17055	COG3629	intracellular signal transduction
SD37_17055	COG3903	Transcriptional regulator
SD37_17125	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_17125	COG2508	Transcriptional regulator
SD37_17210	COG0667	Aldo Keto reductase
SD37_17240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_17255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SD37_17310	COG1082	Xylose isomerase domain protein TIM barrel
SD37_17345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_17395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SD37_17405	COG0494	nUDIX hydrolase
SD37_17435	COG1857	crispr-associated protein
SD37_17465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_17475	COG1960	acyl-CoA dehydrogenase activity
SD37_17490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SD37_17495	COG1012	belongs to the aldehyde dehydrogenase family
SD37_17520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SD37_17520	COG3291	Pkd domain containing protein
SD37_17525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_17550	COG0583	DNA-binding transcription factor activity
SD37_17595	COG2367	Beta-lactamase
SD37_17610	COG2326	polyphosphate kinase activity
SD37_17625	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_17635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_17675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SD37_17680	COG0277	FAD linked oxidase domain protein
SD37_17680	COG0247	lactate metabolic process
SD37_17685	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_17690	COG2132	Multicopper oxidase
SD37_17700	COG0583	DNA-binding transcription factor activity
SD37_17740	COG3903	Transcriptional regulator
SD37_17740	COG3629	intracellular signal transduction
SD37_17810	COG0673	inositol 2-dehydrogenase activity
SD37_17850	COG2080	2 iron, 2 sulfur cluster binding
SD37_17855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SD37_17860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SD37_17870	COG1609	Transcriptional regulator
SD37_17885	COG3833	ABC-type maltose transport systems, permease component
SD37_17910	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SD37_17915	COG0714	Associated with various cellular activities
SD37_17950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD37_18000	COG1609	Transcriptional regulator
SD37_18025	COG1609	Transcriptional regulator
SD37_18040	COG0395	ABC-type sugar transport system, permease component
SD37_18045	COG4209	transmembrane transport
SD37_18055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD37_18065	COG0667	Aldo Keto reductase
SD37_18100	COG1764	response to oxidative stress
SD37_18105	COG3629	intracellular signal transduction
SD37_18105	COG3903	Transcriptional regulator
SD37_18135	COG0477	Major facilitator Superfamily
SD37_18145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SD37_18165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_18175	COG2197	response regulator
SD37_18185	COG1414	Transcriptional regulator
SD37_18190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SD37_18195	COG0277	FAD linked oxidase domain protein
SD37_18200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_18220	COG0745	RESPONSE REGULATOR receiver
SD37_18225	COG2205	protein histidine kinase activity
SD37_18295	COG0701	Predicted permease
SD37_18310	COG1802	Transcriptional regulator
SD37_18315	COG1012	belongs to the aldehyde dehydrogenase family
SD37_18330	COG0667	Aldo Keto reductase
SD37_18340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD37_18345	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_18365	COG0601	transmembrane transport
SD37_18370	COG0747	negative chemotaxis
SD37_18395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SD37_18410	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_18450	COG4977	sequence-specific DNA binding
SD37_18465	COG1253	flavin adenine dinucleotide binding
SD37_18470	COG0129	dihydroxy-acid dehydratase activity
SD37_18495	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_18510	COG0277	FAD linked oxidase domain protein
SD37_18515	COG0583	DNA-binding transcription factor activity
SD37_18520	COG0006	proline dipeptidase activity
SD37_18545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_18550	COG3938	Belongs to the proline racemase family
SD37_18555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD37_18565	COG0477	Major facilitator Superfamily
SD37_18635	COG1414	Transcriptional regulator
SD37_18645	COG0778	Nitroreductase
SD37_18650	COG0583	DNA-binding transcription factor activity
SD37_18670	COG0154	amidase activity
SD37_18730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_18740	COG2124	cytochrome p450
SD37_18745	COG2124	cytochrome p450
SD37_18775	COG2197	response regulator
SD37_18780	COG4585	Histidine kinase
SD37_18805	COG1595	DNA-templated transcription, initiation
SD37_18815	COG1024	Enoyl-CoA hydratase
SD37_18825	COG0488	(ABC) transporter
SD37_18860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SD37_18885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SD37_18890	COG1132	(ABC) transporter
SD37_18895	COG1132	(ABC) transporter
SD37_18900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_18905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_18920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_18925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_18955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_18995	COG0640	Transcriptional regulator
SD37_19015	COG0523	cobalamin synthesis protein
SD37_19025	COG0254	rRNA binding
SD37_19035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SD37_19040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SD37_19045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SD37_19050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SD37_19060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SD37_19060	COG1648	precorrin-2 dehydrogenase activity
SD37_19075	COG1024	Enoyl-CoA hydratase
SD37_19080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_19095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SD37_19135	COG0509	glycine decarboxylation via glycine cleavage system
SD37_19140	COG1716	ATPase activity
SD37_19165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_19165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_19180	COG0656	L-ascorbic acid biosynthetic process
SD37_19230	COG2267	carboxylic ester hydrolase activity
SD37_19245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_19250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SD37_19255	COG0121	glutamine amidotransferase
SD37_19260	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SD37_19285	COG0477	Major facilitator Superfamily
SD37_19290	COG0583	DNA-binding transcription factor activity
SD37_19300	COG1285	pathogenesis
SD37_19310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SD37_19315	COG3883	PFAM NLP P60 protein
SD37_19315	COG0791	NLP P60 protein
SD37_19320	COG0746	molybdenum cofactor guanylyltransferase activity
SD37_19330	COG0714	Associated with various cellular activities
SD37_19340	COG2304	oxidoreductase activity
SD37_19345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SD37_19350	COG3540	Alkaline phosphatase
SD37_19375	COG2205	protein histidine kinase activity
SD37_19380	COG0745	RESPONSE REGULATOR receiver
SD37_19385	COG0477	Major facilitator Superfamily
SD37_19395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SD37_19420	COG3226	Transcriptional regulator
SD37_19425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_19440	COG4585	Histidine kinase
SD37_19455	COG4867	von Willebrand factor, type A
SD37_19465	COG0789	Transcriptional regulator
SD37_19470	COG0215	cysteine-tRNA ligase activity
SD37_19475	COG0488	(ABC) transporter
SD37_19480	COG1846	Transcriptional regulator
SD37_19505	COG0646	methionine synthase
SD37_19505	COG1410	methionine synthase
SD37_19510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_19525	COG0140	phosphoribosyl-ATP diphosphatase activity
SD37_19530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SD37_19535	COG1192	Involved in chromosome partitioning
SD37_19550	COG1994	Peptidase M50
SD37_19550	COG0517	IMP dehydrogenase activity
SD37_19570	COG1222	aaa ATPase
SD37_19610	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SD37_19615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SD37_19635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SD37_19655	COG0640	Transcriptional regulator
SD37_19670	COG1733	regulation of RNA biosynthetic process
SD37_19680	COG2378	regulation of single-species biofilm formation
SD37_19690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SD37_19700	COG1597	lipid kinase activity
SD37_19730	COG4552	Acetyltransferase involved in intracellular survival and related
SD37_19800	COG4221	oxidoreductase activity
SD37_19805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_19835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_19840	COG2362	D-Aminopeptidase
SD37_19850	COG0488	(ABC) transporter
SD37_19875	COG1595	DNA-templated transcription, initiation
SD37_19885	COG0183	Belongs to the thiolase family
SD37_19890	COG1733	regulation of RNA biosynthetic process
SD37_19935	COG0601	transmembrane transport
SD37_19945	COG4172	Belongs to the ABC transporter superfamily
SD37_19965	COG1619	proteins homologs of microcin C7 resistance protein MccF
SD37_20020	COG0640	Transcriptional regulator
SD37_20030	COG1309	transcriptional regulator
SD37_20040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_20065	COG0235	Class ii aldolase
SD37_20070	COG3395	kinase activity
SD37_20080	COG3622	Belongs to the hyi family
SD37_20085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD37_20095	COG0596	Alpha beta hydrolase
SD37_20105	COG0583	DNA-binding transcription factor activity
SD37_20110	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_20130	COG4974	Belongs to the 'phage' integrase family
SD37_20140	COG0590	tRNA wobble adenosine to inosine editing
SD37_20150	COG1522	sequence-specific DNA binding
SD37_20160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_20190	COG0477	Major facilitator Superfamily
SD37_20200	COG2226	methyltransferase
SD37_20210	COG0596	Alpha beta hydrolase
SD37_20240	COG2755	lipolytic protein G-D-S-L family
SD37_20250	COG1357	PFAM Pentapeptide repeats (8 copies)
SD37_20255	COG4221	oxidoreductase activity
SD37_20270	COG0702	epimerase
SD37_20285	COG4941	Belongs to the sigma-70 factor family
SD37_20325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD37_20345	COG1960	acyl-CoA dehydrogenase activity
SD37_20350	COG1309	transcriptional regulator
SD37_20360	COG1595	DNA-templated transcription, initiation
SD37_20365	COG2318	DinB family
SD37_20375	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_20380	COG2226	methyltransferase
SD37_20385	COG2226	methyltransferase
SD37_20395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SD37_20420	COG1435	thymidine kinase activity
SD37_20430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_20450	COG0463	Glycosyl transferase, family 2
SD37_20460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD37_20480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SD37_20510	COG1278	Cold shock
SD37_20535	COG1982	Orn Lys Arg decarboxylase major
SD37_20550	COG0587	DNA-directed DNA polymerase activity
SD37_20575	COG2197	response regulator
SD37_20595	COG2814	Major facilitator Superfamily
SD37_20615	COG3345	alpha-galactosidase
SD37_20640	COG2826	transposase and inactivated derivatives, IS30 family
SD37_20655	COG0395	ABC-type sugar transport system, permease component
SD37_20660	COG1175	transmembrane transport
SD37_20685	COG0259	pyridoxamine-phosphate oxidase activity
SD37_20715	COG0387	Pfam Sodium calcium exchanger
SD37_20720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SD37_20730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_20740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_20755	COG2226	methyltransferase
SD37_20775	COG0395	ABC-type sugar transport system, permease component
SD37_20780	COG1175	transmembrane transport
SD37_20790	COG1609	Transcriptional regulator
SD37_20795	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_20805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SD37_20830	COG0697	spore germination
SD37_20840	COG2084	Dehydrogenase
SD37_20860	COG1136	(ABC) transporter
SD37_20865	COG1136	(ABC) transporter
SD37_20875	COG3537	Alpha-1,2-mannosidase
SD37_20880	COG0477	Major facilitator Superfamily
SD37_20890	COG1595	DNA-templated transcription, initiation
SD37_20930	COG1846	Transcriptional regulator
SD37_20935	COG0039	L-malate dehydrogenase activity
SD37_20945	COG0789	Transcriptional regulator
SD37_20980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_20985	COG1104	cysteine desulfurase activity
SD37_20990	COG0339	signal peptide processing
SD37_21000	COG1968	undecaprenyl-diphosphatase activity
SD37_21005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_21010	COG0667	Aldo Keto reductase
SD37_21040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_21065	COG0739	heme binding
SD37_21080	COG3540	Alkaline phosphatase
SD37_21105	COG4585	Histidine kinase
SD37_21145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_21190	COG1295	ribonuclease BN
SD37_21205	COG3903	Transcriptional regulator
SD37_21205	COG2197	response regulator
SD37_21225	COG3404	Formiminotransferase-cyclodeaminase
SD37_21230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SD37_21240	COG2264	protein methyltransferase activity
SD37_21365	COG2115	Belongs to the xylose isomerase family
SD37_21370	COG1940	carbohydrate kinase activity
SD37_21370	COG1846	Transcriptional regulator
SD37_21400	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_21420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SD37_21475	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_21480	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_21485	COG1129	ABC transporter
SD37_21490	COG1879	ABC-type sugar transport system periplasmic component
SD37_21495	COG1609	Transcriptional regulator
SD37_21500	COG4585	Histidine kinase
SD37_21505	COG2197	response regulator
SD37_21540	COG1136	(ABC) transporter
SD37_21545	COG4977	sequence-specific DNA binding
SD37_21565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_21565	COG1672	PFAM Archaeal ATPase
SD37_21615	COG0745	RESPONSE REGULATOR receiver
SD37_21635	COG0444	Belongs to the ABC transporter superfamily
SD37_21645	COG4166	transmembrane transport
SD37_21670	COG2508	Transcriptional regulator
SD37_21670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_21675	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_21690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SD37_21695	COG2723	6-phospho-beta-galactosidase activity
SD37_21700	COG0395	ABC-type sugar transport system, permease component
SD37_21705	COG1175	transmembrane transport
SD37_21735	COG1733	regulation of RNA biosynthetic process
SD37_21755	COG2814	Major facilitator Superfamily
SD37_21760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SD37_21760	COG2755	lipolytic protein G-D-S-L family
SD37_21765	COG5002	protein histidine kinase activity
SD37_21770	COG0745	RESPONSE REGULATOR receiver
SD37_21775	COG5297	Belongs to the glycosyl hydrolase family 6
SD37_21800	COG0395	ABC-type sugar transport system, permease component
SD37_21805	COG1175	transmembrane transport
SD37_21810	COG1609	Transcriptional regulator
SD37_21815	COG0702	epimerase
SD37_21820	COG1846	Transcriptional regulator
SD37_21825	COG2409	Drug exporters of the RND superfamily
SD37_21850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SD37_21875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SD37_21905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SD37_21925	COG1414	Transcriptional regulator
SD37_21930	COG0477	Major facilitator Superfamily
SD37_21955	COG3971	2-oxopent-4-enoate hydratase activity
SD37_21965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SD37_21970	COG4733	cellulase activity
SD37_21970	COG5297	Belongs to the glycosyl hydrolase family 6
SD37_21985	COG1733	regulation of RNA biosynthetic process
SD37_21990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SD37_22010	COG3250	beta-galactosidase activity
SD37_22015	COG3940	Belongs to the glycosyl hydrolase 43 family
SD37_22030	COG4214	carbohydrate transport
SD37_22035	COG1129	ABC transporter
SD37_22040	COG4213	ABC transporter substrate-binding protein
SD37_22045	COG2160	L-arabinose isomerase activity
SD37_22060	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_22065	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_22075	COG1879	ABC-type sugar transport system periplasmic component
SD37_22080	COG1609	Transcriptional regulator
SD37_22110	COG0395	ABC-type sugar transport system, permease component
SD37_22115	COG2723	6-phospho-beta-galactosidase activity
SD37_22120	COG0488	(ABC) transporter
SD37_22155	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_22175	COG1090	epimerase
SD37_22180	COG1309	transcriptional regulator
SD37_22190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_22215	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_22220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_22225	COG2197	response regulator
SD37_22235	COG4977	sequence-specific DNA binding
SD37_22275	COG2201	protein-glutamate methylesterase activity
SD37_22320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SD37_22340	COG1522	sequence-specific DNA binding
SD37_22345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD37_22355	COG3285	dna ligase
SD37_22355	COG1793	dna ligase
SD37_22375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_22400	COG3960	tartronate-semialdehyde synthase activity
SD37_22405	COG2084	Dehydrogenase
SD37_22410	COG3622	Belongs to the hyi family
SD37_22415	COG0596	Alpha beta hydrolase
SD37_22435	COG1280	lysine exporter protein (LysE YggA)
SD37_22465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SD37_22480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SD37_22500	COG2018	Roadblock/LC7 domain
SD37_22525	COG3285	dna ligase
SD37_22525	COG1793	dna ligase
SD37_22550	COG3629	intracellular signal transduction
SD37_22550	COG3903	Transcriptional regulator
SD37_22575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_22580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SD37_22585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD37_22610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SD37_22615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SD37_22620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_22635	COG2255	four-way junction helicase activity
SD37_22640	COG0632	four-way junction helicase activity
SD37_22645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SD37_22660	COG0217	transcriptional regulatory protein
SD37_22665	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SD37_22690	COG1309	transcriptional regulator
SD37_22735	COG3903	Transcriptional regulator
SD37_22735	COG3629	intracellular signal transduction
SD37_22745	COG2040	homocysteine
SD37_22765	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SD37_22770	COG0277	FAD linked oxidase domain protein
SD37_22780	COG3608	succinylglutamate desuccinylase aspartoacylase
SD37_22780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SD37_22790	COG0438	transferase activity, transferring glycosyl groups
SD37_22795	COG1560	Kdo2-lipid A biosynthetic process
SD37_22825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SD37_22830	COG0778	Nitroreductase
SD37_22895	COG2261	transglycosylase associated protein
SD37_22925	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_22925	COG2319	Wd-40 repeat
SD37_23025	COG0494	nUDIX hydrolase
SD37_23040	COG2815	serine threonine protein kinase
SD37_23040	COG0515	serine threonine protein kinase
SD37_23080	COG3903	Transcriptional regulator
SD37_23080	COG3629	intracellular signal transduction
SD37_23125	COG1960	acyl-CoA dehydrogenase activity
SD37_23135	COG2226	methyltransferase
SD37_23140	COG3509	depolymerase
SD37_23155	COG3507	Belongs to the glycosyl hydrolase 43 family
SD37_23190	COG2197	response regulator
SD37_23195	COG4585	Histidine kinase
SD37_23265	COG0714	Associated with various cellular activities
SD37_23275	COG4221	oxidoreductase activity
SD37_23285	COG3693	PFAM glycoside hydrolase, family 10
SD37_23300	COG4941	Belongs to the sigma-70 factor family
SD37_23320	COG1132	(ABC) transporter
SD37_23325	COG4585	Histidine kinase
SD37_23330	COG2197	response regulator
SD37_23375	COG2197	response regulator
SD37_23380	COG4585	Histidine kinase
SD37_23385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SD37_23390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD37_23440	COG2972	Histidine kinase
SD37_23440	COG2205	protein histidine kinase activity
SD37_23445	COG0745	RESPONSE REGULATOR receiver
SD37_23450	COG3033	Beta-eliminating lyase
SD37_23455	COG0475	glutathione-regulated potassium exporter activity
SD37_23490	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_23500	COG1609	Transcriptional regulator
SD37_23510	COG1501	Belongs to the glycosyl hydrolase 31 family
SD37_23530	COG3250	beta-galactosidase activity
SD37_23535	COG0673	inositol 2-dehydrogenase activity
SD37_23545	COG3401	FG-GAP repeat protein
SD37_23560	COG3866	Pectate lyase
SD37_23570	COG0673	inositol 2-dehydrogenase activity
SD37_23580	COG0395	ABC-type sugar transport system, permease component
SD37_23585	COG1175	transmembrane transport
SD37_23595	COG1609	Transcriptional regulator
SD37_23605	COG1609	Transcriptional regulator
SD37_23610	COG1609	Transcriptional regulator
SD37_23660	COG4585	Histidine kinase
SD37_23665	COG2197	response regulator
SD37_23670	COG2197	response regulator
SD37_23710	COG1522	sequence-specific DNA binding
SD37_23720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD37_23725	COG0596	Alpha beta hydrolase
SD37_23735	COG0706	membrane insertase activity
SD37_23760	COG0488	(ABC) transporter
SD37_23770	COG0515	serine threonine protein kinase
SD37_23770	COG2815	serine threonine protein kinase
SD37_23790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_23800	COG1819	glycosyl
SD37_23805	COG0300	oxidoreductase activity
SD37_23820	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_23825	COG3321	synthase
SD37_23825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_23830	COG0477	Major facilitator Superfamily
SD37_23845	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SD37_23845	COG0515	serine threonine protein kinase
SD37_23850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SD37_23850	COG0515	serine threonine protein kinase
SD37_23920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SD37_23945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_23980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD37_23995	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_24000	COG0667	Aldo Keto reductase
SD37_24025	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_24035	COG0477	Major facilitator Superfamily
SD37_24040	COG1959	2 iron, 2 sulfur cluster binding
SD37_24050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SD37_24055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_24065	COG1414	Transcriptional regulator
SD37_24070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_24095	COG3511	phospholipase C
SD37_24105	COG1335	isochorismatase
SD37_24120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_24125	COG2318	DinB family
SD37_24165	COG2076	Multidrug Resistance protein
SD37_24175	COG0583	DNA-binding transcription factor activity
SD37_24185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_24185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_24225	COG1309	transcriptional regulator
SD37_24250	COG2197	response regulator
SD37_24265	COG2072	flavoprotein involved in K transport
SD37_24270	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_24290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_24310	COG0861	Integral membrane protein TerC family
SD37_24315	COG0583	DNA-binding transcription factor activity
SD37_24325	COG1063	alcohol dehydrogenase
SD37_24335	COG1064	alcohol dehydrogenase
SD37_24375	COG3903	Transcriptional regulator
SD37_24375	COG3629	intracellular signal transduction
SD37_24380	COG2197	response regulator
SD37_24385	COG4585	Histidine kinase
SD37_24390	COG2315	Protein conserved in bacteria
SD37_24405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_24410	COG2826	transposase and inactivated derivatives, IS30 family
SD37_24415	COG0028	Belongs to the TPP enzyme family
SD37_24440	COG1595	DNA-templated transcription, initiation
SD37_24465	COG3903	Transcriptional regulator
SD37_24465	COG3629	intracellular signal transduction
SD37_24470	COG0596	Alpha beta hydrolase
SD37_24485	COG4991	sh3 domain protein
SD37_24515	COG0500	methyltransferase
SD37_24550	COG4981	capsule polysaccharide biosynthetic process
SD37_24570	COG5001	Diguanylate cyclase
SD37_24590	COG3629	intracellular signal transduction
SD37_24590	COG3903	Transcriptional regulator
SD37_24600	COG0596	Alpha beta hydrolase
SD37_24605	COG5492	domain, Protein
SD37_24620	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_24625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_24635	COG1414	Transcriptional regulator
SD37_24640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SD37_24700	COG1160	GTP binding
SD37_24725	COG0475	glutathione-regulated potassium exporter activity
SD37_24730	COG2936	dipeptidyl-peptidase activity
SD37_24740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SD37_24770	COG0504	CTP synthase activity
SD37_24775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SD37_24785	COG1802	Transcriptional regulator
SD37_24790	COG1953	Uracil, thiamine, allantoin
SD37_24815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SD37_24830	COG0647	UMP catabolic process
SD37_24855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SD37_24860	COG2094	Belongs to the DNA glycosylase MPG family
SD37_24880	COG0165	Argininosuccinate lyase
SD37_24885	COG0137	argininosuccinate synthase activity
SD37_24890	COG1438	arginine binding
SD37_24895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SD37_24900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD37_24905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SD37_24910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SD37_24915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SD37_24940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_24940	COG0072	phenylalanine-tRNA ligase activity
SD37_24945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SD37_24955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_24960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SD37_24965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SD37_24980	COG1802	Transcriptional regulator
SD37_24985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SD37_25010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SD37_25015	COG2610	gluconate transmembrane transporter activity
SD37_25020	COG2706	6-phosphogluconolactonase activity
SD37_25065	COG3321	synthase
SD37_25065	COG0604	alcohol dehydrogenase
SD37_25075	COG4565	transcriptional regulatory protein
SD37_25080	COG3290	protein histidine kinase activity
SD37_25085	COG1301	dicarboxylic acid transport
SD37_25095	COG1733	regulation of RNA biosynthetic process
SD37_25140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_25230	COG3012	SEC-C Motif Domain Protein
SD37_25235	COG3250	beta-galactosidase activity
SD37_25275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_25280	COG1609	Transcriptional regulator
SD37_25295	COG0823	Involved in the tonB-independent uptake of proteins
SD37_25295	COG4946	Tricorn protease homolog
SD37_25295	COG1506	peptidase
SD37_25305	COG1131	(ABC) transporter
SD37_25320	COG1024	Enoyl-CoA hydratase
SD37_25365	COG0237	dephospho-CoA kinase activity
SD37_25365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SD37_25375	COG0539	negative regulation of cytoplasmic translation
SD37_25380	COG2226	methyltransferase
SD37_25400	COG1511	domain protein
SD37_25415	COG1653	transport
SD37_25450	COG0583	DNA-binding transcription factor activity
SD37_25490	COG0187	DNA topoisomerase II activity
SD37_25500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SD37_25505	COG1501	Belongs to the glycosyl hydrolase 31 family
SD37_25510	COG1349	DNA-binding transcription factor activity
SD37_25525	COG0395	ABC-type sugar transport system, permease component
SD37_25550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_25580	COG2188	Transcriptional regulator
SD37_25600	COG2066	Belongs to the glutaminase family
SD37_25620	COG0583	DNA-binding transcription factor activity
SD37_25630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SD37_25680	COG3845	ABC transporter
SD37_25725	COG0411	ABC transporter
SD37_25730	COG0410	ABC transporter
SD37_25735	COG0559	Belongs to the binding-protein-dependent transport system permease family
SD37_25780	COG1846	Transcriptional regulator
SD37_25785	COG3665	Urea carboxylase-associated protein
SD37_25790	COG1902	pentaerythritol trinitrate reductase activity
SD37_25790	COG0446	pyridine nucleotide-disulphide oxidoreductase
SD37_25810	COG0740	serine-type endopeptidase activity
SD37_25815	COG0740	serine-type endopeptidase activity
SD37_25820	COG1396	sequence-specific DNA binding
SD37_25880	COG2197	response regulator
SD37_25900	COG1595	DNA-templated transcription, initiation
SD37_25905	COG3629	intracellular signal transduction
SD37_25905	COG3903	Transcriptional regulator
SD37_25935	COG4941	Belongs to the sigma-70 factor family
SD37_25940	COG3795	YCII-related domain
SD37_25945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_26030	COG0596	Alpha beta hydrolase
SD37_26055	COG2197	response regulator
SD37_26060	COG3903	Transcriptional regulator
SD37_26060	COG3629	intracellular signal transduction
SD37_26070	COG2197	response regulator
SD37_26075	COG1819	glycosyl
SD37_26085	COG0583	DNA-binding transcription factor activity
SD37_26095	COG0583	DNA-binding transcription factor activity
SD37_26100	COG2826	transposase and inactivated derivatives, IS30 family
SD37_26110	COG3546	catalase activity
SD37_26115	COG0473	3-isopropylmalate dehydrogenase activity
SD37_26125	COG2610	gluconate transmembrane transporter activity
SD37_26150	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_26155	COG0798	PFAM Bile acid sodium symporter
SD37_26165	COG0640	Transcriptional regulator
SD37_26180	COG0583	DNA-binding transcription factor activity
SD37_26190	COG1733	regulation of RNA biosynthetic process
SD37_26200	COG0427	acetyl-CoA hydrolase
SD37_26225	COG3268	Saccharopine dehydrogenase
SD37_26260	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_26265	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_26270	COG2172	sigma factor antagonist activity
SD37_26285	COG0789	Transcriptional regulator
SD37_26285	COG4978	Transcriptional regulator
SD37_26300	COG1252	NADH dehydrogenase
SD37_26305	COG1595	DNA-templated transcription, initiation
SD37_26395	COG1247	-acetyltransferase
SD37_26410	COG3973	AAA domain
SD37_26415	COG2124	cytochrome p450
SD37_26430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_26440	COG1309	transcriptional regulator
SD37_26445	COG2318	DinB family
SD37_26450	COG4447	cellulose binding
SD37_26450	COG5520	Belongs to the glycosyl hydrolase 30 family
SD37_26450	COG3291	Pkd domain containing protein
SD37_26455	COG3903	Transcriptional regulator
SD37_26455	COG3629	intracellular signal transduction
SD37_26470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_26475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SD37_26480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SD37_26485	COG2423	ornithine cyclodeaminase activity
SD37_26495	COG1733	regulation of RNA biosynthetic process
SD37_26500	COG0028	Belongs to the TPP enzyme family
SD37_26530	COG2211	Major facilitator Superfamily
SD37_26535	COG0583	DNA-binding transcription factor activity
SD37_26580	COG1309	transcriptional regulator
SD37_26600	COG2197	response regulator
SD37_26675	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_26685	COG2124	cytochrome p450
SD37_26695	COG1131	(ABC) transporter
SD37_26705	COG2311	Membrane
SD37_26725	COG2986	histidine ammonia-lyase
SD37_26730	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_26775	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
SD37_26790	COG0477	Major facilitator Superfamily
SD37_26810	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_26830	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SD37_26850	COG2197	response regulator
SD37_26855	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_26855	COG2319	Wd-40 repeat
SD37_26865	COG2814	Major facilitator Superfamily
SD37_26880	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SD37_26905	COG3629	intracellular signal transduction
SD37_26905	COG3903	Transcriptional regulator
SD37_26915	COG1032	radical SAM domain protein
SD37_26960	COG1785	Belongs to the alkaline phosphatase family
SD37_26995	COG1595	DNA-templated transcription, initiation
SD37_27015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_27025	COG1280	lysine exporter protein (LysE YggA)
SD37_27035	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SD37_27040	COG3629	intracellular signal transduction
SD37_27040	COG3903	Transcriptional regulator
SD37_27060	COG0640	Transcriptional regulator
SD37_27075	COG0596	Alpha beta hydrolase
SD37_27125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_27130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_27130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_27150	COG0640	Transcriptional regulator
SD37_27155	COG0514	ATP-dependent DNA helicase (RecQ)
SD37_27165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SD37_27185	COG0542	response to heat
SD37_27190	COG0477	Major facilitator Superfamily
SD37_27200	COG0667	Aldo Keto reductase
SD37_27220	COG0667	Aldo Keto reductase
SD37_27235	COG2010	Cytochrome c
SD37_27235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SD37_27250	COG1940	carbohydrate kinase activity
SD37_27275	COG1309	transcriptional regulator
SD37_27280	COG0640	Transcriptional regulator
SD37_27300	COG0248	Ppx GppA phosphatase
SD37_27305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_27325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SD37_27350	COG0640	Transcriptional regulator
SD37_27360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SD37_27390	COG3599	regulation of cell shape
SD37_27400	COG1799	cell septum assembly
SD37_27405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SD37_27425	COG1595	DNA-templated transcription, initiation
SD37_27440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_27450	COG2318	DinB family
SD37_27460	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SD37_27470	COG0596	Alpha beta hydrolase
SD37_27480	COG0067	glutamate synthase
SD37_27480	COG0069	glutamate synthase activity
SD37_27480	COG0070	glutamate synthase
SD37_27495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SD37_27515	COG0159	tryptophan synthase activity
SD37_27520	COG0133	tryptophan synthase activity
SD37_27525	COG0134	indole-3-glycerol-phosphate synthase activity
SD37_27535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SD37_27555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SD37_27565	COG0107	imidazoleglycerol-phosphate synthase activity
SD37_27570	COG1309	transcriptional regulator
SD37_27620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SD37_27625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SD37_27635	COG1960	acyl-CoA dehydrogenase activity
SD37_27650	COG3958	Transketolase
SD37_27655	COG3959	Transketolase, thiamine diphosphate binding domain
SD37_27665	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SD37_27670	COG1309	transcriptional regulator
SD37_27675	COG2409	Drug exporters of the RND superfamily
SD37_27695	COG0131	Imidazoleglycerol-phosphate dehydratase
SD37_27705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SD37_27715	COG1522	sequence-specific DNA binding
SD37_27720	COG3386	PFAM SMP-30 Gluconolaconase
SD37_27725	COG2197	response regulator
SD37_27775	COG1674	ftsk spoiiie
SD37_27785	COG3896	Chloramphenicol phosphotransferase-like protein
SD37_27835	COG1404	Belongs to the peptidase S8 family
SD37_27840	COG0157	Belongs to the NadC ModD family
SD37_27845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SD37_27850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SD37_27875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SD37_27880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SD37_27885	COG0659	secondary active sulfate transmembrane transporter activity
SD37_27890	COG0659	secondary active sulfate transmembrane transporter activity
SD37_27895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD37_27900	COG2124	cytochrome p450
SD37_27915	COG0438	transferase activity, transferring glycosyl groups
SD37_27970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SD37_27985	COG1845	cytochrome c oxidase, subunit III
SD37_28030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SD37_28065	COG0667	Aldo Keto reductase
SD37_28075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SD37_28090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SD37_28100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD37_28120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SD37_28165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_28170	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_28185	COG1090	epimerase
SD37_28195	COG0321	lipoyl(octanoyl) transferase activity
SD37_28220	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_28225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SD37_28230	COG0586	Pfam SNARE associated Golgi protein
SD37_28235	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD37_28245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SD37_28270	COG0477	Major facilitator Superfamily
SD37_28275	COG0587	DNA-directed DNA polymerase activity
SD37_28295	COG1113	amino acid transport
SD37_28355	COG0454	-acetyltransferase
SD37_28355	COG0456	acetyltransferase
SD37_28395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SD37_28405	COG3201	nicotinamide mononucleotide transporter
SD37_28410	COG0668	transmembrane transport
SD37_28425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SD37_28440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SD37_28465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_28475	COG0095	Lipoate-protein ligase
SD37_28480	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SD37_28485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SD37_28490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SD37_28520	COG2197	response regulator
SD37_28530	COG1396	sequence-specific DNA binding
SD37_28570	COG0442	prolyl-tRNA aminoacylation
SD37_28595	COG3022	response to hydroperoxide
SD37_28615	COG1404	Belongs to the peptidase S8 family
SD37_28645	COG0513	Belongs to the DEAD box helicase family
SD37_28650	COG0156	8-amino-7-oxononanoate synthase activity
SD37_28675	COG2807	transmembrane transport
SD37_28680	COG2186	Transcriptional regulator
SD37_28695	COG0454	-acetyltransferase
SD37_28695	COG0456	acetyltransferase
SD37_28700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SD37_28705	COG0750	zinc metalloprotease
SD37_28710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SD37_28725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SD37_28750	COG2755	lipolytic protein G-D-S-L family
SD37_28750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SD37_28760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_28770	COG2124	cytochrome p450
SD37_28795	COG1476	TRANSCRIPTIONal
SD37_28805	COG3540	Alkaline phosphatase
SD37_28835	COG0076	glutamate decarboxylase activity
SD37_28885	COG1595	DNA-templated transcription, initiation
SD37_28890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SD37_28900	COG1695	Transcriptional regulator
SD37_28930	COG0528	UMP kinase activity
SD37_28935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SD37_28940	COG0052	Belongs to the universal ribosomal protein uS2 family
SD37_28950	COG1191	sigma factor activity
SD37_28965	COG0606	chelatase, subunit chli
SD37_28980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SD37_28985	COG0681	Belongs to the peptidase S26 family
SD37_28990	COG0335	large ribosomal subunit rRNA binding
SD37_28995	COG0336	Belongs to the RNA methyltransferase TrmD family
SD37_29010	COG0228	four-way junction DNA binding
SD37_29040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SD37_29050	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SD37_29105	COG2873	o-acetylhomoserine
SD37_29110	COG1832	CoA-binding protein
SD37_29120	COG4266	Belongs to the allantoicase family
SD37_29125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD37_29140	COG2351	hydroxyisourate hydrolase activity
SD37_29155	COG1309	transcriptional regulator
SD37_29165	COG2252	PERMEase
SD37_29170	COG0590	tRNA wobble adenosine to inosine editing
SD37_29175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SD37_29195	COG3835	regulator
SD37_29205	COG1301	dicarboxylic acid transport
SD37_29240	COG1414	Transcriptional regulator
SD37_29250	COG0477	Major facilitator Superfamily
SD37_29265	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SD37_29300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SD37_29305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SD37_29310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SD37_29320	COG0367	asparagine synthase
SD37_29335	COG1131	(ABC) transporter
SD37_29340	COG1725	Transcriptional regulator
SD37_29345	COG3629	intracellular signal transduction
SD37_29345	COG3903	Transcriptional regulator
SD37_29355	COG0673	inositol 2-dehydrogenase activity
SD37_29365	COG1082	Xylose isomerase domain protein TIM barrel
SD37_29370	COG1879	ABC-type sugar transport system periplasmic component
SD37_29385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_29390	COG3718	enzyme involved in inositol metabolism
SD37_29395	COG3962	Belongs to the TPP enzyme family
SD37_29415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_29455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_29460	COG1522	sequence-specific DNA binding
SD37_29495	COG1414	Transcriptional regulator
SD37_29500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_29505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_29510	COG3485	protocatechuate 3,4-dioxygenase
SD37_29515	COG3485	protocatechuate 3,4-dioxygenase
SD37_29525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SD37_29530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SD37_29545	COG1929	Belongs to the glycerate kinase type-1 family
SD37_29595	COG2186	Transcriptional regulator
SD37_29600	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_29605	COG1129	ABC transporter
SD37_29620	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_29625	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_29630	COG2814	Major facilitator Superfamily
SD37_29645	COG4221	oxidoreductase activity
SD37_29655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_29660	COG1120	ATPase activity
SD37_29670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_29675	COG2186	Transcriptional regulator
SD37_29680	COG1760	l-serine dehydratase
SD37_29685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SD37_29690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SD37_29695	COG0509	glycine decarboxylation via glycine cleavage system
SD37_29700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SD37_29705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_29705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_29720	COG1012	belongs to the aldehyde dehydrogenase family
SD37_29725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SD37_29730	COG0174	glutamine synthetase
SD37_29755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_29790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD37_29795	COG0571	ribonuclease III activity
SD37_29800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SD37_29830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SD37_29835	COG0742	ribosomal rna small subunit methyltransferase
SD37_29840	COG3973	AAA domain
SD37_29845	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_29845	COG2319	Wd-40 repeat
SD37_29850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_29860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_29885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SD37_29940	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SD37_29945	COG1404	Belongs to the peptidase S8 family
SD37_29990	COG1461	Dihydroxyacetone kinase
SD37_29995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SD37_30000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SD37_30005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SD37_30040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_30050	COG2205	protein histidine kinase activity
SD37_30055	COG0745	RESPONSE REGULATOR receiver
SD37_30080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_30085	COG0252	asparaginase activity
SD37_30095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SD37_30120	COG3629	intracellular signal transduction
SD37_30120	COG3903	Transcriptional regulator
SD37_30125	COG0776	regulation of translation
SD37_30130	COG0066	3-isopropylmalate dehydratase activity
SD37_30135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SD37_30140	COG1414	Transcriptional regulator
SD37_30150	COG2378	regulation of single-species biofilm formation
SD37_30160	COG0745	RESPONSE REGULATOR receiver
SD37_30165	COG0464	growth
SD37_30175	COG0745	RESPONSE REGULATOR receiver
SD37_30180	COG2205	protein histidine kinase activity
SD37_30230	COG1674	ftsk spoiiie
SD37_30280	COG0714	Associated with various cellular activities
SD37_30320	COG0583	DNA-binding transcription factor activity
SD37_30340	COG1733	regulation of RNA biosynthetic process
SD37_30375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SD37_30410	COG1404	Belongs to the peptidase S8 family
SD37_30445	COG0583	DNA-binding transcription factor activity
SD37_30480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SD37_30540	COG1082	Xylose isomerase domain protein TIM barrel
SD37_30545	COG1401	restriction endodeoxyribonuclease activity
SD37_30585	COG4106	trans-aconitate 2-methyltransferase activity
SD37_30600	COG1595	DNA-templated transcription, initiation
SD37_30605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_30625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SD37_30635	COG2197	response regulator
SD37_30640	COG4585	Histidine kinase
SD37_30650	COG1131	(ABC) transporter
SD37_30655	COG0423	glycine-tRNA ligase activity
SD37_30690	COG0701	Predicted permease
SD37_30700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SD37_30705	COG1381	Involved in DNA repair and RecF pathway recombination
SD37_30720	COG1714	RDD family
SD37_30740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SD37_30755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SD37_30765	COG0537	adenosine 5'-monophosphoramidase activity
SD37_30780	COG0484	heat shock protein binding
SD37_30785	COG1420	regulation of RNA biosynthetic process
SD37_30815	COG2205	protein histidine kinase activity
SD37_30820	COG0745	RESPONSE REGULATOR receiver
SD37_30825	COG1953	Uracil, thiamine, allantoin
SD37_30835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD37_30845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_30905	COG0463	Glycosyl transferase, family 2
SD37_30915	COG2192	nodulation
SD37_30955	COG0175	sulfate reduction
SD37_30980	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SD37_30985	COG2732	(Barnase) inhibitor
SD37_31000	COG0604	alcohol dehydrogenase
SD37_31010	COG0583	DNA-binding transcription factor activity
SD37_31025	COG0531	amino acid
SD37_31030	COG2070	2-Nitropropane dioxygenase
SD37_31045	COG0481	GTPase activity
SD37_31050	COG2226	methyltransferase
SD37_31065	COG0268	Binds directly to 16S ribosomal RNA
SD37_31080	COG2333	competence protein COMEC
SD37_31080	COG0658	competence protein
SD37_31085	COG1555	photosystem II stabilization
SD37_31090	COG1307	EDD domain protein, DegV family
SD37_31100	COG0406	alpha-ribazole phosphatase activity
SD37_31105	COG0799	negative regulation of ribosome biogenesis
SD37_31110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SD37_31120	COG0477	Major facilitator Superfamily
SD37_31125	COG0018	arginyl-trna synthetase
SD37_31145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SD37_31150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SD37_31155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SD37_31160	COG1530	ribonuclease E activity
SD37_31170	COG0842	Transport permease protein
SD37_31180	COG1131	(ABC) transporter
SD37_31200	COG0105	UTP biosynthetic process
SD37_31210	COG2366	antibiotic biosynthetic process
SD37_31220	COG0285	dihydrofolate synthase activity
SD37_31235	COG0525	valine-tRNA ligase activity
SD37_31260	COG1316	TRANSCRIPTIONal
SD37_31275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SD37_31310	COG0740	serine-type endopeptidase activity
SD37_31320	COG0544	peptidyl-prolyl cis-trans isomerase activity
SD37_31325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SD37_31330	COG2205	protein histidine kinase activity
SD37_31335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_31340	COG0463	Glycosyl transferase, family 2
SD37_31345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_31380	COG2814	Major facilitator Superfamily
SD37_31405	COG2815	serine threonine protein kinase
SD37_31405	COG0515	serine threonine protein kinase
SD37_31420	COG0693	protein deglycase activity
SD37_31435	COG5002	protein histidine kinase activity
SD37_31435	COG0784	Response regulator, receiver
SD37_31490	COG4941	Belongs to the sigma-70 factor family
SD37_31500	COG3345	alpha-galactosidase
SD37_31525	COG0698	ribose 5-phosphate isomerase
SD37_31540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SD37_31550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SD37_31570	COG0668	transmembrane transport
SD37_31610	COG2902	Dehydrogenase
SD37_31645	COG0738	Major facilitator superfamily
SD37_31650	COG1609	Transcriptional regulator
SD37_31760	COG1309	transcriptional regulator
SD37_31780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_31795	COG1733	regulation of RNA biosynthetic process
SD37_31805	COG1113	amino acid transport
SD37_31815	COG1846	Transcriptional regulator
SD37_31830	COG1793	dna ligase
SD37_31830	COG3285	dna ligase
SD37_31835	COG3285	dna ligase
SD37_31835	COG1793	dna ligase
SD37_31850	COG1136	(ABC) transporter
SD37_31850	COG0577	efflux transmembrane transporter activity
SD37_31860	COG4585	Histidine kinase
SD37_31865	COG2197	response regulator
SD37_31880	COG0300	oxidoreductase activity
SD37_31900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_31905	COG2197	response regulator
SD37_31910	COG1917	Cupin 2, conserved barrel domain protein
SD37_31910	COG4977	sequence-specific DNA binding
SD37_31920	COG2197	response regulator
SD37_31930	COG1733	regulation of RNA biosynthetic process
SD37_31935	COG0009	L-threonylcarbamoyladenylate synthase
SD37_31945	COG2197	response regulator
SD37_31970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_31995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_32030	COG2124	cytochrome p450
SD37_32050	COG1917	Cupin 2, conserved barrel domain protein
SD37_32050	COG4977	sequence-specific DNA binding
SD37_32065	COG3629	intracellular signal transduction
SD37_32095	COG3795	YCII-related domain
SD37_32100	COG1937	Protein conserved in bacteria
SD37_32135	COG2267	carboxylic ester hydrolase activity
SD37_32140	COG4221	oxidoreductase activity
SD37_32150	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SD37_32175	COG0745	RESPONSE REGULATOR receiver
SD37_32180	COG2205	protein histidine kinase activity
SD37_32215	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_32230	COG1063	alcohol dehydrogenase
SD37_32245	COG0596	Alpha beta hydrolase
SD37_32290	COG1609	Transcriptional regulator
SD37_32305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SD37_32310	COG0745	RESPONSE REGULATOR receiver
SD37_32320	COG1136	(ABC) transporter
SD37_32325	COG4181	ATPase activity
SD37_32330	COG5002	protein histidine kinase activity
SD37_32365	COG1733	regulation of RNA biosynthetic process
SD37_32410	COG1024	Enoyl-CoA hydratase
SD37_32455	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_32465	COG1643	Atp-dependent helicase
SD37_32475	COG0475	glutathione-regulated potassium exporter activity
SD37_32505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SD37_32505	COG1796	DNA polymerase
SD37_32515	COG1802	Transcriptional regulator
SD37_32535	COG3706	GGDEF domain
SD37_32540	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SD37_32545	COG0010	Belongs to the arginase family
SD37_32550	COG0412	Dienelactone hydrolase
SD37_32555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD37_32570	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SD37_32570	COG0235	Class ii aldolase
SD37_32585	COG4552	Acetyltransferase involved in intracellular survival and related
SD37_32600	COG1309	transcriptional regulator
SD37_32615	COG0247	lactate metabolic process
SD37_32615	COG0277	FAD linked oxidase domain protein
SD37_32625	COG2197	response regulator
SD37_32630	COG0410	ABC transporter
SD37_32640	COG0559	Belongs to the binding-protein-dependent transport system permease family
SD37_32645	COG0559	Belongs to the binding-protein-dependent transport system permease family
SD37_32660	COG1522	sequence-specific DNA binding
SD37_32675	COG1739	Uncharacterized protein family UPF0029
SD37_32680	COG0067	glutamate synthase
SD37_32680	COG0070	glutamate synthase
SD37_32680	COG0069	glutamate synthase activity
SD37_32710	COG0300	oxidoreductase activity
SD37_32715	COG1492	cobalamin metabolic process
SD37_32720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SD37_32730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SD37_32735	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SD37_32750	COG1797	cobyrinic acid a,c-diamide synthase activity
SD37_32790	COG3973	AAA domain
SD37_32795	COG2319	Wd-40 repeat
SD37_32795	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_32820	COG1131	(ABC) transporter
SD37_32830	COG1476	TRANSCRIPTIONal
SD37_32840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD37_32840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD37_32850	COG0488	(ABC) transporter
SD37_32855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SD37_32860	COG2151	metal-sulfur cluster biosynthetic enzyme
SD37_32865	COG3396	Phenylacetate-CoA oxygenase
SD37_32870	COG3460	Phenylacetate-CoA oxygenase
SD37_32875	COG3396	Phenylacetate-CoA oxygenase
SD37_32880	COG2030	dehydratase
SD37_32880	COG1012	belongs to the aldehyde dehydrogenase family
SD37_32925	COG2072	flavoprotein involved in K transport
SD37_32940	COG2183	response to ionizing radiation
SD37_32955	COG0513	Belongs to the DEAD box helicase family
SD37_32965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_32970	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SD37_32980	COG4585	Histidine kinase
SD37_32985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SD37_32990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SD37_33000	COG3540	Alkaline phosphatase
SD37_33005	COG4991	sh3 domain protein
SD37_33010	COG3903	Transcriptional regulator
SD37_33010	COG3629	intracellular signal transduction
SD37_33015	COG4991	sh3 domain protein
SD37_33075	COG1131	(ABC) transporter
SD37_33080	COG2826	transposase and inactivated derivatives, IS30 family
SD37_33085	COG0596	Alpha beta hydrolase
SD37_33100	COG1126	abc transporter atp-binding protein
SD37_33105	COG0765	amino acid transport
SD37_33110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_33180	COG1116	anion transmembrane transporter activity
SD37_33190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_33270	COG1309	transcriptional regulator
SD37_33275	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_33280	COG0604	alcohol dehydrogenase
SD37_33300	COG3693	PFAM glycoside hydrolase, family 10
SD37_33310	COG0596	Alpha beta hydrolase
SD37_33345	COG0714	Associated with various cellular activities
SD37_33365	COG0515	serine threonine protein kinase
SD37_33365	COG2815	serine threonine protein kinase
SD37_33375	COG2205	protein histidine kinase activity
SD37_33380	COG0745	RESPONSE REGULATOR receiver
SD37_33385	COG3903	Transcriptional regulator
SD37_33385	COG3629	intracellular signal transduction
SD37_33410	COG1231	oxidoreductase activity
SD37_33415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SD37_33440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_33450	COG5001	Diguanylate cyclase
SD37_33460	COG2124	cytochrome p450
SD37_33490	COG1846	Transcriptional regulator
SD37_33495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_33560	COG0402	S-adenosylhomocysteine deaminase activity
SD37_33570	COG0574	Belongs to the PEP-utilizing enzyme family
SD37_33570	COG3848	Pyruvate phosphate dikinase
SD37_33585	COG0667	Aldo Keto reductase
SD37_33590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SD37_33595	COG1024	Enoyl-CoA hydratase
SD37_33600	COG1024	Enoyl-CoA hydratase
SD37_33605	COG1024	Enoyl-CoA hydratase
SD37_33610	COG3424	synthase
SD37_33615	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SD37_33635	COG0475	glutathione-regulated potassium exporter activity
SD37_33660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_33685	COG1819	glycosyl
SD37_33690	COG1819	glycosyl
SD37_33700	COG2124	cytochrome p450
SD37_33705	COG2124	cytochrome p450
SD37_33710	COG2124	cytochrome p450
SD37_33735	COG1132	(ABC) transporter
SD37_33755	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SD37_33760	COG1181	Belongs to the D-alanine--D-alanine ligase family
SD37_33855	COG3511	phospholipase C
SD37_33865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_33895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_33955	COG2207	Transcriptional regulator
SD37_33980	COG2124	cytochrome p450
SD37_34020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SD37_34030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_34065	COG3291	Pkd domain containing protein
SD37_34090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SD37_34110	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_34115	COG1129	ABC transporter
SD37_34130	COG1940	carbohydrate kinase activity
SD37_34135	COG0477	Major facilitator Superfamily
SD37_34160	COG2826	transposase and inactivated derivatives, IS30 family
SD37_34180	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_34190	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SD37_34255	COG0367	asparagine synthase
SD37_34260	COG2197	response regulator
SD37_34265	COG2197	response regulator
SD37_34300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_34305	COG0475	glutathione-regulated potassium exporter activity
SD37_34310	COG4565	transcriptional regulatory protein
SD37_34315	COG3290	protein histidine kinase activity
SD37_34395	COG2255	four-way junction helicase activity
SD37_34415	COG2181	nitrate reductase activity
SD37_34415	COG0247	lactate metabolic process
SD37_34425	COG1121	(ABC) transporter
SD37_34430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD37_34445	COG1120	ATPase activity
SD37_34460	COG0326	Molecular chaperone. Has ATPase activity
SD37_34475	COG3835	regulator
SD37_34490	COG0596	Alpha beta hydrolase
SD37_34535	COG1175	transmembrane transport
SD37_34540	COG0395	ABC-type sugar transport system, permease component
SD37_34545	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_34555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_34560	COG2084	Dehydrogenase
SD37_34580	COG0483	inositol monophosphate 1-phosphatase activity
SD37_34590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_34605	COG0438	transferase activity, transferring glycosyl groups
SD37_34640	COG5001	Diguanylate cyclase
SD37_34645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_34665	COG1793	dna ligase
SD37_34665	COG3285	dna ligase
SD37_34705	COG0667	Aldo Keto reductase
SD37_34725	COG3795	YCII-related domain
SD37_34750	COG0187	DNA topoisomerase II activity
SD37_34755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SD37_34760	COG1960	acyl-CoA dehydrogenase activity
SD37_34765	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_34770	COG2030	dehydratase
SD37_34780	COG0183	Belongs to the thiolase family
SD37_34790	COG0473	3-isopropylmalate dehydrogenase activity
SD37_34790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SD37_34800	COG0583	DNA-binding transcription factor activity
SD37_34815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_34820	COG1643	Atp-dependent helicase
SD37_34830	COG1131	(ABC) transporter
SD37_34855	COG2197	response regulator
SD37_34860	COG4585	Histidine kinase
SD37_34875	COG1228	amidohydrolase
SD37_34880	COG0402	S-adenosylhomocysteine deaminase activity
SD37_34890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SD37_34895	COG2986	histidine ammonia-lyase
SD37_34910	COG0596	Alpha beta hydrolase
SD37_34930	COG4585	Histidine kinase
SD37_34935	COG2197	response regulator
SD37_34955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SD37_34960	COG2177	Part of the ABC transporter FtsEX involved in
SD37_34965	COG2884	Cell division ATP-binding protein ftsE
SD37_34970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SD37_35000	COG1615	UPF0182 protein
SD37_35010	COG3480	Lon protease (S16) C-terminal proteolytic domain
SD37_35080	COG0174	glutamine synthetase
SD37_35090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SD37_35110	COG1522	sequence-specific DNA binding
SD37_35130	COG0154	amidase activity
SD37_35135	COG0174	glutamine synthetase
SD37_35160	COG0653	protein targeting
SD37_35165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SD37_35165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_35180	COG2318	DinB family
SD37_35185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SD37_35185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD37_35190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SD37_35200	COG0596	Alpha beta hydrolase
SD37_35210	COG1177	transmembrane transport
SD37_35215	COG1176	ABC-type spermidine putrescine transport system, permease component I
SD37_35220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SD37_35225	COG3842	ATPase activity
SD37_35230	COG1012	belongs to the aldehyde dehydrogenase family
SD37_35255	COG1012	belongs to the aldehyde dehydrogenase family
SD37_35260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD37_35265	COG0557	exoribonuclease II activity
SD37_35355	COG2197	response regulator
SD37_35370	COG0328	RNA-DNA hybrid ribonuclease activity
SD37_35370	COG0406	alpha-ribazole phosphatase activity
SD37_35380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SD37_35410	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SD37_35420	COG3265	gluconokinase activity
SD37_35430	COG0640	Transcriptional regulator
SD37_35445	COG1486	melibiose metabolic process
SD37_35450	COG0395	ABC-type sugar transport system, permease component
SD37_35455	COG1175	transmembrane transport
SD37_35480	COG0612	Peptidase, M16
SD37_35530	COG0714	Associated with various cellular activities
SD37_35580	COG0210	DNA helicase
SD37_35595	COG4585	Histidine kinase
SD37_35605	COG2378	regulation of single-species biofilm formation
SD37_35620	COG0745	RESPONSE REGULATOR receiver
SD37_35625	COG2146	nitrite reductase [NAD(P)H] activity
SD37_35625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD37_35630	COG2146	nitrite reductase [NAD(P)H] activity
SD37_35630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD37_35635	COG2223	nitrite transmembrane transporter activity
SD37_35640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD37_35645	COG0243	molybdopterin cofactor binding
SD37_35655	COG1136	(ABC) transporter
SD37_35685	COG0596	Alpha beta hydrolase
SD37_35695	COG0402	S-adenosylhomocysteine deaminase activity
SD37_35710	COG2267	carboxylic ester hydrolase activity
SD37_35745	COG0513	Belongs to the DEAD box helicase family
SD37_35770	COG2095	MarC family integral membrane protein
SD37_35775	COG0613	PHP domain protein
SD37_35800	COG0598	Magnesium transport protein CorA
SD37_35820	COG1309	transcriptional regulator
SD37_35885	COG0330	HflC and HflK could
SD37_35895	COG2239	Acts as a magnesium transporter
SD37_35910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SD37_35915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD37_35940	COG2814	Major facilitator Superfamily
SD37_35950	COG0671	phosphoesterase, PA-phosphatase related
SD37_35955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SD37_35965	COG1024	Enoyl-CoA hydratase
SD37_35975	COG0519	Catalyzes the synthesis of GMP from XMP
SD37_36010	COG1271	oxidase subunit
SD37_36015	COG1294	oxidase, subunit
SD37_36020	COG4988	ABC transporter
SD37_36030	COG0463	Glycosyl transferase, family 2
SD37_36045	COG1611	Belongs to the LOG family
SD37_36050	COG3291	Pkd domain containing protein
SD37_36090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_36100	COG2171	N-acyltransferase activity
SD37_36145	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SD37_36145	COG0778	Nitroreductase
SD37_36160	COG1725	Transcriptional regulator
SD37_36185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_36205	COG0438	transferase activity, transferring glycosyl groups
SD37_36235	COG1316	TRANSCRIPTIONal
SD37_36240	COG1316	TRANSCRIPTIONal
SD37_36250	COG2259	Doxx family
SD37_36320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SD37_36330	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_36335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SD37_36385	COG2197	response regulator
SD37_36390	COG2197	response regulator
SD37_36405	COG2205	protein histidine kinase activity
SD37_36415	COG0483	inositol monophosphate 1-phosphatase activity
SD37_36445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SD37_36445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SD37_36450	COG3103	Sh3 type 3 domain protein
SD37_36450	COG0791	NLP P60 protein
SD37_36450	COG1388	LysM domain
SD37_36455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_36500	COG0640	Transcriptional regulator
SD37_36515	COG2249	NAD(P)H dehydrogenase (quinone) activity
SD37_36520	COG0655	NAD(P)H dehydrogenase (quinone) activity
SD37_36535	COG4585	Histidine kinase
SD37_36540	COG2197	response regulator
SD37_36545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_36580	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_36585	COG0424	maF-like protein
SD37_36590	COG1301	dicarboxylic acid transport
SD37_36605	COG4770	biotin carboxylase activity
SD37_36630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SD37_36635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SD37_36640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_36680	COG1473	amidohydrolase
SD37_36680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_36735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD37_36760	COG1228	amidohydrolase
SD37_36775	COG0667	Aldo Keto reductase
SD37_36780	COG0667	Aldo Keto reductase
SD37_36810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_36815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SD37_36820	COG1012	belongs to the aldehyde dehydrogenase family
SD37_36825	COG1012	belongs to the aldehyde dehydrogenase family
SD37_36845	COG0395	ABC-type sugar transport system, permease component
SD37_36860	COG1063	alcohol dehydrogenase
SD37_36865	COG2390	Transcriptional regulator
SD37_36870	COG1733	regulation of RNA biosynthetic process
SD37_36895	COG2271	Major facilitator Superfamily
SD37_36900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SD37_36940	COG3345	alpha-galactosidase
SD37_36955	COG2009	succinate dehydrogenase
SD37_36970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SD37_36985	COG1404	Belongs to the peptidase S8 family
SD37_36995	COG1686	Belongs to the peptidase S11 family
SD37_37000	COG1295	ribonuclease BN
SD37_37005	COG0180	Tryptophanyl-tRNA synthetase
SD37_37045	COG1234	tRNA 3'-trailer cleavage
SD37_37075	COG2264	protein methyltransferase activity
SD37_37085	COG1522	sequence-specific DNA binding
SD37_37095	COG0667	Aldo Keto reductase
SD37_37145	COG2814	Major facilitator Superfamily
SD37_37150	COG0640	Transcriptional regulator
SD37_37155	COG2814	Major facilitator Superfamily
SD37_37190	COG0587	DNA-directed DNA polymerase activity
SD37_37205	COG1073	alpha beta
SD37_37230	COG0138	bifunctional purine biosynthesis protein purh
SD37_37255	COG0045	succinate-CoA ligase (ADP-forming) activity
SD37_37270	COG0739	heme binding
SD37_37325	COG0583	DNA-binding transcription factor activity
SD37_37365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SD37_37365	COG0519	Catalyzes the synthesis of GMP from XMP
SD37_37380	COG1012	belongs to the aldehyde dehydrogenase family
SD37_37385	COG0277	FAD linked oxidase domain protein
SD37_37390	COG1120	ATPase activity
SD37_37395	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_37400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_37405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD37_37420	COG0516	GMP reductase activity
SD37_37470	COG0459	protein refolding
SD37_37475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SD37_37485	COG1215	transferase activity, transferring glycosyl groups
SD37_37505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SD37_37510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SD37_37515	COG0456	acetyltransferase
SD37_37525	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_37530	COG0825	malonyl-CoA metabolic process
SD37_37530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SD37_37535	COG0802	atpase or kinase
SD37_37545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SD37_37550	COG3842	ATPase activity
SD37_37555	COG1070	Carbohydrate kinase
SD37_37570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_37595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD37_37625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD37_37635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SD37_37665	COG0443	Heat shock 70 kDa protein
SD37_37670	COG1674	ftsk spoiiie
SD37_37680	COG1404	Belongs to the peptidase S8 family
SD37_37715	COG0101	tRNA pseudouridine synthase activity
SD37_37720	COG0203	ribosomal protein L17
SD37_37725	COG0202	RNA polymerase activity
SD37_37730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SD37_37735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SD37_37745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SD37_37750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SD37_37765	COG0563	adenylate kinase activity
SD37_37775	COG1280	lysine exporter protein (LysE YggA)
SD37_37790	COG1841	ribosomal large subunit assembly
SD37_37795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SD37_37800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SD37_37805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SD37_37810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SD37_37820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SD37_37825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SD37_37830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SD37_37835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SD37_37840	COG0255	Belongs to the universal ribosomal protein uL29 family
SD37_37845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SD37_37850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SD37_37855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SD37_37860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SD37_37865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SD37_37870	COG0089	rRNA binding
SD37_37875	COG0088	Forms part of the polypeptide exit tunnel
SD37_37880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SD37_37885	COG0051	transcription antitermination factor activity, RNA binding
SD37_37895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SD37_37900	COG0049	tRNA binding
SD37_37905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SD37_37960	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SD37_37965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_37970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SD37_38000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SD37_38025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_38045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SD37_38060	COG0081	regulation of translation
SD37_38065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SD37_38085	COG0436	Aminotransferase
SD37_38090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_38095	COG2755	lipolytic protein G-D-S-L family
SD37_38105	COG2030	dehydratase
SD37_38110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SD37_38140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SD37_38150	COG0586	Pfam SNARE associated Golgi protein
SD37_38155	COG4585	Histidine kinase
SD37_38160	COG2197	response regulator
SD37_38165	COG0640	Transcriptional regulator
SD37_38170	COG0346	lactoylglutathione lyase activity
SD37_38280	COG1666	GTP binding
SD37_38300	COG0501	Belongs to the peptidase M48B family
SD37_38330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SD37_38345	COG4310	Domain of unknown function (DUF2172)
SD37_38355	COG0463	Glycosyl transferase, family 2
SD37_38355	COG1216	Glycosyl transferase, family 2
SD37_38370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD37_38420	COG0367	asparagine synthase
SD37_38440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD37_38465	COG1834	amidinotransferase
SD37_38470	COG1522	sequence-specific DNA binding
SD37_38480	COG0674	pyruvate-flavodoxin oxidoreductase activity
SD37_38480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SD37_38485	COG1013	pyruvate-flavodoxin oxidoreductase activity
SD37_38525	COG1196	nuclear chromosome segregation
SD37_38560	COG1007	ATP synthesis coupled electron transport
SD37_38570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SD37_38575	COG0713	ATP synthesis coupled electron transport
SD37_38580	COG0839	Belongs to the complex I subunit 6 family
SD37_38585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD37_38590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SD37_38595	COG1034	ATP synthesis coupled electron transport
SD37_38610	COG0649	NAD binding
SD37_38615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD37_38620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD37_38635	COG2226	methyltransferase
SD37_38645	COG0438	transferase activity, transferring glycosyl groups
SD37_38670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SD37_38675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SD37_38700	COG1522	sequence-specific DNA binding
SD37_38720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SD37_38730	COG0785	Cytochrome C biogenesis protein
SD37_38750	COG0406	alpha-ribazole phosphatase activity
SD37_38755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD37_38760	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SD37_38800	COG1914	H( )-stimulated, divalent metal cation uptake system
SD37_38805	COG2826	transposase and inactivated derivatives, IS30 family
SD37_38815	COG1648	precorrin-2 dehydrogenase activity
SD37_38815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SD37_38820	COG0181	hydroxymethylbilane synthase activity
SD37_38825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SD37_38830	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SD37_38845	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_38850	COG1595	DNA-templated transcription, initiation
SD37_38860	COG0560	Phosphoserine phosphatase
SD37_38880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SD37_38910	COG5002	protein histidine kinase activity
SD37_38925	COG0588	phosphoglycerate mutase activity
SD37_38940	COG0438	transferase activity, transferring glycosyl groups
SD37_38955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SD37_38985	COG2130	NADP-dependent
SD37_39010	COG2986	histidine ammonia-lyase
SD37_39035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SD37_39040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SD37_39040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SD37_39060	COG2733	membrane
SD37_39080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_39085	COG2364	Membrane
SD37_39110	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SD37_39120	COG3226	Transcriptional regulator
SD37_39130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_39190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SD37_39205	COG2233	PERMEase
SD37_39270	COG1278	Cold shock
SD37_39285	COG1595	DNA-templated transcription, initiation
SD37_39305	COG0515	serine threonine protein kinase
SD37_39330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_39340	COG2197	response regulator
SD37_39365	COG4585	Histidine kinase
SD37_39370	COG2197	response regulator
SD37_39380	COG0028	Belongs to the TPP enzyme family
SD37_39395	COG1132	(ABC) transporter
SD37_39400	COG1132	(ABC) transporter
SD37_39405	COG0515	serine threonine protein kinase
SD37_39445	COG4585	Histidine kinase
SD37_39450	COG2197	response regulator
SD37_39480	COG1278	Cold shock
SD37_39550	COG1278	Cold shock
SD37_39560	COG0587	DNA-directed DNA polymerase activity
SD37_39575	COG3629	intracellular signal transduction
SD37_39575	COG3903	Transcriptional regulator
SD37_39650	COG0270	DNA (cytosine-5-)-methyltransferase activity
SD37_39705	COG0791	NLP P60 protein
SD37_39705	COG1388	LysM domain
SD37_39705	COG3103	Sh3 type 3 domain protein
SD37_39795	COG0714	Associated with various cellular activities
SD37_39930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SD37_39940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SD37_39950	COG0463	Glycosyl transferase, family 2
SD37_39970	COG0438	transferase activity, transferring glycosyl groups
SD37_40015	COG0602	queuosine metabolic process
SD37_40065	COG2318	DinB family
SD37_40070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SD37_40105	COG1846	Transcriptional regulator
SD37_40120	COG1902	pentaerythritol trinitrate reductase activity
SD37_40120	COG0446	pyridine nucleotide-disulphide oxidoreductase
SD37_40125	COG0287	Prephenate dehydrogenase
SD37_40135	COG2175	clavaminate synthase activity
SD37_40175	COG0702	epimerase
SD37_40190	COG1131	(ABC) transporter
SD37_40195	COG3559	Exporter of polyketide antibiotics
SD37_40230	COG2172	sigma factor antagonist activity
SD37_40250	COG0667	Aldo Keto reductase
SD37_40280	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_40285	COG1309	transcriptional regulator
SD37_40305	COG0556	nucleotide-excision repair
SD37_40325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SD37_40325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD37_40330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_40355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SD37_40360	COG2826	transposase and inactivated derivatives, IS30 family
SD37_40375	COG2186	Transcriptional regulator
SD37_40380	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SD37_40400	COG1522	sequence-specific DNA binding
SD37_40420	COG1672	PFAM Archaeal ATPase
SD37_40420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_40465	COG0504	CTP synthase activity
SD37_40525	COG2234	aminopeptidase activity
SD37_40530	COG3321	synthase
SD37_40530	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_40530	COG0604	alcohol dehydrogenase
SD37_40545	COG0596	Alpha beta hydrolase
SD37_40575	COG1216	Glycosyl transferase, family 2
SD37_40605	COG1216	Glycosyl transferase, family 2
SD37_40615	COG0277	FAD linked oxidase domain protein
SD37_40620	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_40660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SD37_40665	COG0671	phosphoesterase, PA-phosphatase related
SD37_40680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_40685	COG0561	phosphatase activity
SD37_40730	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_40735	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_40750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD37_40790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SD37_40805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD37_40830	COG0477	Major facilitator Superfamily
SD37_40845	COG0579	oxidoreductase
SD37_40855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SD37_40860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD37_40865	COG0596	Alpha beta hydrolase
SD37_40870	COG3766	membrane
SD37_40875	COG0754	glutathionylspermidine amidase activity
SD37_40910	COG0406	alpha-ribazole phosphatase activity
SD37_40920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SD37_40925	COG1072	(Pantothenic acid kinase))
SD37_40950	COG4715	Zinc finger, swim domain protein
SD37_41005	COG4988	ABC transporter
SD37_41010	COG1294	oxidase, subunit
SD37_41015	COG1271	oxidase subunit
SD37_41080	COG2235	arginine
SD37_41095	COG1191	sigma factor activity
SD37_41135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_41145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_41170	COG3275	phosphorelay sensor kinase activity
SD37_41180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD37_41240	COG0438	transferase activity, transferring glycosyl groups
SD37_41260	COG2197	response regulator
SD37_41265	COG4585	Histidine kinase
SD37_41280	COG0477	Major facilitator Superfamily
SD37_41295	COG0405	Gamma-glutamyltransferase
SD37_41315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD37_41325	COG2226	methyltransferase
SD37_41350	COG1174	glycine betaine transport
SD37_41360	COG1174	glycine betaine transport
SD37_41375	COG1276	copper resistance
SD37_41375	COG2372	response to copper ion
SD37_41435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SD37_41440	COG0702	epimerase
SD37_41460	COG2301	Belongs to the HpcH HpaI aldolase family
SD37_41485	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_41490	COG1012	belongs to the aldehyde dehydrogenase family
SD37_41500	COG0444	Belongs to the ABC transporter superfamily
SD37_41515	COG0747	negative chemotaxis
SD37_41520	COG2186	Transcriptional regulator
SD37_41545	COG0626	cystathionine gamma-synthase activity
SD37_41550	COG0667	Aldo Keto reductase
SD37_41570	COG1716	ATPase activity
SD37_41575	COG1716	ATPase activity
SD37_41590	COG0768	penicillin binding
SD37_41595	COG0515	serine threonine protein kinase
SD37_41650	COG3764	Sortase (surface protein transpeptidase)
SD37_41670	COG0705	Rhomboid family
SD37_41670	COG0457	Tetratricopeptide repeat
SD37_41755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SD37_41760	COG0187	DNA topoisomerase II activity
SD37_41770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SD37_41775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SD37_41780	COG0592	DNA-directed DNA polymerase activity