locus-tag	class	description
AORI_0002	COG0592	DNA-directed DNA polymerase activity
AORI_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AORI_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AORI_0006	COG0187	DNA topoisomerase II activity
AORI_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AORI_0014	COG2197	response regulator
AORI_0015	COG4585	Histidine kinase
AORI_0015	COG2203	Gaf domain
AORI_0027	COG0457	Tetratricopeptide repeat
AORI_0027	COG0705	Rhomboid family
AORI_0031	COG3764	Sortase (surface protein transpeptidase)
AORI_0045	COG0515	serine threonine protein kinase
AORI_0046	COG0768	penicillin binding
AORI_0049	COG1716	ATPase activity
AORI_0050	COG1716	ATPase activity
AORI_0053	COG0626	cystathionine gamma-synthase activity
AORI_0059	COG0747	negative chemotaxis
AORI_0062	COG0444	Belongs to the ABC transporter superfamily
AORI_0064	COG1012	belongs to the aldehyde dehydrogenase family
AORI_0066	COG0154	amidase activity
AORI_0068	COG2301	Belongs to the HpcH HpaI aldolase family
AORI_0072	COG0702	epimerase
AORI_0073	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AORI_0085	COG1276	copper resistance
AORI_0085	COG2372	response to copper ion
AORI_0088	COG1174	glycine betaine transport
AORI_0090	COG1174	glycine betaine transport
AORI_0095	COG2226	methyltransferase
AORI_0097	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_0101	COG0405	Gamma-glutamyltransferase
AORI_0104	COG0477	Major facilitator Superfamily
AORI_0107	COG4585	Histidine kinase
AORI_0108	COG2197	response regulator
AORI_0112	COG0438	transferase activity, transferring glycosyl groups
AORI_0113	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AORI_0127	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AORI_0129	COG3275	phosphorelay sensor kinase activity
AORI_0134	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_0136	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_0144	COG1191	sigma factor activity
AORI_0147	COG2235	arginine
AORI_0160	COG1271	oxidase subunit
AORI_0161	COG1294	oxidase, subunit
AORI_0162	COG4988	ABC transporter
AORI_0174	COG4715	Zinc finger, swim domain protein
AORI_0176	COG1072	(Pantothenic acid kinase))
AORI_0177	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AORI_0179	COG0406	alpha-ribazole phosphatase activity
AORI_0186	COG0754	glutathionylspermidine amidase activity
AORI_0187	COG3766	membrane
AORI_0188	COG0596	Alpha beta hydrolase
AORI_0189	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AORI_0190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AORI_0193	COG0579	oxidoreductase
AORI_0196	COG0477	Major facilitator Superfamily
AORI_0201	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AORI_0203	COG0438	transferase activity, transferring glycosyl groups
AORI_0204	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AORI_0212	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AORI_0215	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_0216	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_0224	COG0561	phosphatase activity
AORI_0225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_0229	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AORI_0234	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_0235	COG0277	FAD linked oxidase domain protein
AORI_0237	COG1216	Glycosyl transferase, family 2
AORI_0244	COG1216	Glycosyl transferase, family 2
AORI_0250	COG2089	acid synthase
AORI_0251	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AORI_0252	COG1086	Polysaccharide biosynthesis protein
AORI_0253	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AORI_0257	COG0596	Alpha beta hydrolase
AORI_0260	COG3321	synthase
AORI_0260	COG0604	alcohol dehydrogenase
AORI_0260	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_0261	COG2234	aminopeptidase activity
AORI_0264	COG4941	Belongs to the sigma-70 factor family
AORI_0265	COG3795	YCII-related domain
AORI_0275	COG0504	CTP synthase activity
AORI_0278	COG3209	COG3209 Rhs family protein
AORI_0284	COG1672	PFAM Archaeal ATPase
AORI_0284	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_0287	COG1522	sequence-specific DNA binding
AORI_0288	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AORI_0291	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AORI_0292	COG2186	Transcriptional regulator
AORI_0295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AORI_0300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_0301	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AORI_0301	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AORI_0304	COG0556	nucleotide-excision repair
AORI_0308	COG1309	transcriptional regulator
AORI_0309	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_0325	COG3559	Exporter of polyketide antibiotics
AORI_0326	COG1131	(ABC) transporter
AORI_0329	COG0702	epimerase
AORI_0337	COG2175	clavaminate synthase activity
AORI_0339	COG0287	Prephenate dehydrogenase
AORI_0340	COG1902	pentaerythritol trinitrate reductase activity
AORI_0340	COG0446	pyridine nucleotide-disulphide oxidoreductase
AORI_0343	COG1846	Transcriptional regulator
AORI_0350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AORI_0351	COG2318	DinB family
AORI_0364	COG0402	S-adenosylhomocysteine deaminase activity
AORI_0366	COG2233	PERMEase
AORI_0368	COG1278	Cold shock
AORI_0370	COG2197	response regulator
AORI_0371	COG4585	Histidine kinase
AORI_0378	COG0515	serine threonine protein kinase
AORI_0380	COG1132	(ABC) transporter
AORI_0381	COG1132	(ABC) transporter
AORI_0384	COG0028	Belongs to the TPP enzyme family
AORI_0389	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_0393	COG0515	serine threonine protein kinase
AORI_0397	COG1595	DNA-templated transcription, initiation
AORI_0400	COG1278	Cold shock
AORI_0409	COG2233	PERMEase
AORI_0412	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AORI_0425	COG3226	Transcriptional regulator
AORI_0432	COG2364	Membrane
AORI_0433	COG2186	Transcriptional regulator
AORI_0437	COG2733	membrane
AORI_0441	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AORI_0442	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AORI_0447	COG2986	histidine ammonia-lyase
AORI_0451	COG2130	NADP-dependent
AORI_0457	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AORI_0459	COG2267	carboxylic ester hydrolase activity
AORI_0460	COG0438	transferase activity, transferring glycosyl groups
AORI_0463	COG0588	phosphoglycerate mutase activity
AORI_0466	COG5002	protein histidine kinase activity
AORI_0472	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AORI_0476	COG0560	Phosphoserine phosphatase
AORI_0478	COG1595	DNA-templated transcription, initiation
AORI_0479	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_0482	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AORI_0483	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AORI_0484	COG0181	hydroxymethylbilane synthase activity
AORI_0485	COG1648	precorrin-2 dehydrogenase activity
AORI_0485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AORI_0487	COG1914	H( )-stimulated, divalent metal cation uptake system
AORI_0493	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AORI_0494	COG0406	alpha-ribazole phosphatase activity
AORI_0496	COG0785	Cytochrome C biogenesis protein
AORI_0498	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AORI_0502	COG1522	sequence-specific DNA binding
AORI_0508	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AORI_0509	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AORI_0514	COG0438	transferase activity, transferring glycosyl groups
AORI_0516	COG2226	methyltransferase
AORI_0519	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AORI_0520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AORI_0521	COG0649	NAD binding
AORI_0524	COG1034	ATP synthesis coupled electron transport
AORI_0525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AORI_0526	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AORI_0527	COG0839	Belongs to the complex I subunit 6 family
AORI_0528	COG0713	ATP synthesis coupled electron transport
AORI_0529	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AORI_0531	COG1007	ATP synthesis coupled electron transport
AORI_0539	COG1196	nuclear chromosome segregation
AORI_0546	COG1013	pyruvate-flavodoxin oxidoreductase activity
AORI_0547	COG0674	pyruvate-flavodoxin oxidoreductase activity
AORI_0547	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AORI_0549	COG1522	sequence-specific DNA binding
AORI_0550	COG1834	amidinotransferase
AORI_0554	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_0558	COG0367	asparagine synthase
AORI_0572	COG1215	transferase activity, transferring glycosyl groups
AORI_0574	COG4310	Domain of unknown function (DUF2172)
AORI_0577	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AORI_0583	COG0501	Belongs to the peptidase M48B family
AORI_0589	COG1666	GTP binding
AORI_0594	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AORI_0600	COG0346	lactoylglutathione lyase activity
AORI_0601	COG0640	Transcriptional regulator
AORI_0602	COG2197	response regulator
AORI_0603	COG4585	Histidine kinase
AORI_0604	COG0586	Pfam SNARE associated Golgi protein
AORI_0607	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AORI_0611	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AORI_0612	COG2030	dehydratase
AORI_0616	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_0617	COG0436	Aminotransferase
AORI_0620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AORI_0621	COG0081	regulation of translation
AORI_0624	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AORI_0625	COG0222	ribosome binding
AORI_0628	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_0633	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AORI_0639	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AORI_0640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_0652	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AORI_0653	COG0049	tRNA binding
AORI_0654	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AORI_0656	COG0051	transcription antitermination factor activity, RNA binding
AORI_0657	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AORI_0658	COG0088	Forms part of the polypeptide exit tunnel
AORI_0659	COG0089	rRNA binding
AORI_0660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AORI_0661	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AORI_0662	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AORI_0663	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AORI_0664	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AORI_0665	COG0255	Belongs to the universal ribosomal protein uL29 family
AORI_0666	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AORI_0667	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AORI_0668	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AORI_0669	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AORI_0671	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AORI_0672	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AORI_0674	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AORI_0675	COG1841	ribosomal large subunit assembly
AORI_0678	COG1280	lysine exporter protein (LysE YggA)
AORI_0680	COG0563	adenylate kinase activity
AORI_0683	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AORI_0684	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AORI_0686	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AORI_0687	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AORI_0688	COG0202	RNA polymerase activity
AORI_0689	COG0203	ribosomal protein L17
AORI_0690	COG0101	tRNA pseudouridine synthase activity
AORI_0697	COG1404	Belongs to the peptidase S8 family
AORI_0700	COG1674	ftsk spoiiie
AORI_0701	COG0443	Heat shock 70 kDa protein
AORI_0707	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AORI_0708	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AORI_0709	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AORI_0715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AORI_0720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_0722	COG1349	DNA-binding transcription factor activity
AORI_0723	COG1070	Carbohydrate kinase
AORI_0724	COG3842	ATPase activity
AORI_0725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AORI_0727	COG0802	atpase or kinase
AORI_0728	COG0825	malonyl-CoA metabolic process
AORI_0728	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AORI_0729	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_0731	COG0456	acetyltransferase
AORI_0732	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AORI_0733	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AORI_0737	COG1215	transferase activity, transferring glycosyl groups
AORI_0739	COG0546	phosphoglycolate phosphatase activity
AORI_0751	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AORI_0752	COG0459	protein refolding
AORI_0762	COG0516	GMP reductase activity
AORI_0763	COG2318	DinB family
AORI_0766	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AORI_0767	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_0768	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_0769	COG1120	ATPase activity
AORI_0770	COG0277	FAD linked oxidase domain protein
AORI_0771	COG1012	belongs to the aldehyde dehydrogenase family
AORI_0774	COG0519	Catalyzes the synthesis of GMP from XMP
AORI_0774	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AORI_0782	COG0583	DNA-binding transcription factor activity
AORI_0792	COG0739	heme binding
AORI_0795	COG0045	succinate-CoA ligase (ADP-forming) activity
AORI_0800	COG0138	bifunctional purine biosynthesis protein purh
AORI_0809	COG1073	alpha beta
AORI_0819	COG2814	Major facilitator Superfamily
AORI_0820	COG0640	Transcriptional regulator
AORI_0821	COG2814	Major facilitator Superfamily
AORI_0830	COG0667	Aldo Keto reductase
AORI_0832	COG1522	sequence-specific DNA binding
AORI_0834	COG2264	protein methyltransferase activity
AORI_0839	COG1234	tRNA 3'-trailer cleavage
AORI_0848	COG0180	Tryptophanyl-tRNA synthetase
AORI_0849	COG1295	ribonuclease BN
AORI_0850	COG1686	Belongs to the peptidase S11 family
AORI_0852	COG1404	Belongs to the peptidase S8 family
AORI_0856	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AORI_0859	COG2009	succinate dehydrogenase
AORI_0867	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AORI_0868	COG2271	Major facilitator Superfamily
AORI_0874	COG1733	regulation of RNA biosynthetic process
AORI_0876	COG1063	alcohol dehydrogenase
AORI_0879	COG0395	ABC-type sugar transport system, permease component
AORI_0883	COG1012	belongs to the aldehyde dehydrogenase family
AORI_0884	COG1012	belongs to the aldehyde dehydrogenase family
AORI_0885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AORI_0886	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_0894	COG0667	Aldo Keto reductase
AORI_0895	COG0667	Aldo Keto reductase
AORI_0903	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AORI_0913	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_0913	COG1473	amidohydrolase
AORI_0921	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AORI_0922	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AORI_0923	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AORI_0928	COG4770	biotin carboxylase activity
AORI_0931	COG1301	dicarboxylic acid transport
AORI_0932	COG0424	maF-like protein
AORI_0933	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_0940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_0941	COG2197	response regulator
AORI_0942	COG4585	Histidine kinase
AORI_0947	COG0640	Transcriptional regulator
AORI_0956	COG0791	NLP P60 protein
AORI_0956	COG1388	LysM domain
AORI_0956	COG3103	Sh3 type 3 domain protein
AORI_0963	COG0483	inositol monophosphate 1-phosphatase activity
AORI_0965	COG2205	protein histidine kinase activity
AORI_0968	COG2197	response regulator
AORI_0969	COG2197	response regulator
AORI_0972	COG0477	Major facilitator Superfamily
AORI_0981	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AORI_0984	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_0987	COG2259	Doxx family
AORI_0989	COG1316	TRANSCRIPTIONal
AORI_0990	COG1316	TRANSCRIPTIONal
AORI_0996	COG0438	transferase activity, transferring glycosyl groups
AORI_1000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_1005	COG1725	Transcriptional regulator
AORI_1009	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AORI_1009	COG0778	Nitroreductase
AORI_1016	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_1018	COG2171	N-acyltransferase activity
AORI_1020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_1029	COG1611	Belongs to the LOG family
AORI_1032	COG0463	Glycosyl transferase, family 2
AORI_1033	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AORI_1034	COG4988	ABC transporter
AORI_1035	COG1294	oxidase, subunit
AORI_1036	COG1271	oxidase subunit
AORI_1043	COG0519	Catalyzes the synthesis of GMP from XMP
AORI_1045	COG1024	Enoyl-CoA hydratase
AORI_1047	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AORI_1048	COG0671	phosphoesterase, PA-phosphatase related
AORI_1049	COG0583	DNA-binding transcription factor activity
AORI_1050	COG2814	Major facilitator Superfamily
AORI_1051	COG1595	DNA-templated transcription, initiation
AORI_1054	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AORI_1055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AORI_1058	COG2239	Acts as a magnesium transporter
AORI_1060	COG0330	HflC and HflK could
AORI_1064	COG1960	acyl-CoA dehydrogenase activity
AORI_1073	COG1309	transcriptional regulator
AORI_1077	COG0598	Magnesium transport protein CorA
AORI_1083	COG0613	PHP domain protein
AORI_1084	COG2095	MarC family integral membrane protein
AORI_1089	COG0513	Belongs to the DEAD box helicase family
AORI_1097	COG2267	carboxylic ester hydrolase activity
AORI_1100	COG0402	S-adenosylhomocysteine deaminase activity
AORI_1102	COG0596	Alpha beta hydrolase
AORI_1108	COG1136	(ABC) transporter
AORI_1110	COG0243	molybdopterin cofactor binding
AORI_1111	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_1112	COG2223	nitrite transmembrane transporter activity
AORI_1113	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_1113	COG2146	nitrite reductase [NAD(P)H] activity
AORI_1114	COG2146	nitrite reductase [NAD(P)H] activity
AORI_1114	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_1115	COG0745	RESPONSE REGULATOR receiver
AORI_1119	COG2378	regulation of single-species biofilm formation
AORI_1121	COG4585	Histidine kinase
AORI_1124	COG0210	DNA helicase
AORI_1133	COG0714	Associated with various cellular activities
AORI_1134	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AORI_1143	COG0612	Peptidase, M16
AORI_1146	COG1309	transcriptional regulator
AORI_1150	COG1175	transmembrane transport
AORI_1151	COG0395	ABC-type sugar transport system, permease component
AORI_1152	COG1486	melibiose metabolic process
AORI_1155	COG0640	Transcriptional regulator
AORI_1157	COG3265	gluconokinase activity
AORI_1159	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AORI_1165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AORI_1167	COG0406	alpha-ribazole phosphatase activity
AORI_1167	COG0328	RNA-DNA hybrid ribonuclease activity
AORI_1170	COG2197	response regulator
AORI_1191	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AORI_1192	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AORI_1193	COG1012	belongs to the aldehyde dehydrogenase family
AORI_1198	COG1012	belongs to the aldehyde dehydrogenase family
AORI_1199	COG3842	ATPase activity
AORI_1200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AORI_1201	COG1176	ABC-type spermidine putrescine transport system, permease component I
AORI_1202	COG1177	transmembrane transport
AORI_1203	COG5479	isomerase activity
AORI_1203	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_1204	COG0596	Alpha beta hydrolase
AORI_1206	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AORI_1207	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AORI_1207	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AORI_1208	COG2318	DinB family
AORI_1211	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_1211	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AORI_1212	COG0653	protein targeting
AORI_1217	COG0174	glutamine synthetase
AORI_1218	COG0154	amidase activity
AORI_1219	COG1522	sequence-specific DNA binding
AORI_1221	COG0505	Belongs to the CarA family
AORI_1223	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AORI_1225	COG0174	glutamine synthetase
AORI_1236	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AORI_1240	COG3480	Lon protease (S16) C-terminal proteolytic domain
AORI_1242	COG1615	UPF0182 protein
AORI_1247	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AORI_1248	COG2884	Cell division ATP-binding protein ftsE
AORI_1249	COG2177	Part of the ABC transporter FtsEX involved in
AORI_1250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AORI_1254	COG2197	response regulator
AORI_1255	COG4585	Histidine kinase
AORI_1259	COG0596	Alpha beta hydrolase
AORI_1262	COG2986	histidine ammonia-lyase
AORI_1263	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AORI_1265	COG0402	S-adenosylhomocysteine deaminase activity
AORI_1266	COG1228	amidohydrolase
AORI_1269	COG4585	Histidine kinase
AORI_1270	COG2197	response regulator
AORI_1276	COG1643	Atp-dependent helicase
AORI_1277	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_1280	COG0583	DNA-binding transcription factor activity
AORI_1282	COG0473	3-isopropylmalate dehydrogenase activity
AORI_1282	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AORI_1284	COG0183	Belongs to the thiolase family
AORI_1286	COG2030	dehydratase
AORI_1287	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_1288	COG1960	acyl-CoA dehydrogenase activity
AORI_1289	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AORI_1290	COG0187	DNA topoisomerase II activity
AORI_1293	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_1295	COG3795	YCII-related domain
AORI_1298	COG0667	Aldo Keto reductase
AORI_1306	COG3285	dna ligase
AORI_1306	COG1793	dna ligase
AORI_1314	COG1942	4-Oxalocrotonate Tautomerase
AORI_1318	COG0438	transferase activity, transferring glycosyl groups
AORI_1320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AORI_1322	COG0483	inositol monophosphate 1-phosphatase activity
AORI_1323	COG0438	transferase activity, transferring glycosyl groups
AORI_1326	COG2084	Dehydrogenase
AORI_1327	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_1329	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_1330	COG0395	ABC-type sugar transport system, permease component
AORI_1331	COG1175	transmembrane transport
AORI_1336	COG1309	transcriptional regulator
AORI_1342	COG0596	Alpha beta hydrolase
AORI_1345	COG3835	regulator
AORI_1349	COG0326	Molecular chaperone. Has ATPase activity
AORI_1352	COG1120	ATPase activity
AORI_1353	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AORI_1354	COG1121	(ABC) transporter
AORI_1356	COG0247	lactate metabolic process
AORI_1356	COG2181	nitrate reductase activity
AORI_1360	COG2255	four-way junction helicase activity
AORI_1361	COG1403	HNH endonuclease
AORI_1378	COG3290	protein histidine kinase activity
AORI_1379	COG4565	transcriptional regulatory protein
AORI_1381	COG0477	Major facilitator Superfamily
AORI_1382	COG1940	carbohydrate kinase activity
AORI_1384	COG1129	ABC transporter
AORI_1385	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_1387	COG0673	inositol 2-dehydrogenase activity
AORI_1389	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AORI_1391	COG0084	hydrolase, TatD family'
AORI_1394	COG3291	Pkd domain containing protein
AORI_1403	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AORI_1404	COG4977	sequence-specific DNA binding
AORI_1414	COG1131	(ABC) transporter
AORI_1415	COG1725	Transcriptional regulator
AORI_1416	COG5650	phosphatidylinositol metabolic process
AORI_1417	COG2207	Transcriptional regulator
AORI_1423	COG2814	Major facilitator Superfamily
AORI_1436	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_1438	COG3511	phospholipase C
AORI_1440	COG0697	spore germination
AORI_1448	COG0300	oxidoreductase activity
AORI_1458	COG3387	PFAM Glycoside hydrolase 15-related
AORI_1461	COG2909	trisaccharide binding
AORI_1467	COG0628	permease
AORI_1472	COG1181	Belongs to the D-alanine--D-alanine ligase family
AORI_1473	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AORI_1477	COG1132	(ABC) transporter
AORI_1482	COG2124	cytochrome p450
AORI_1483	COG2124	cytochrome p450
AORI_1484	COG2124	cytochrome p450
AORI_1486	COG1819	glycosyl
AORI_1487	COG1819	glycosyl
AORI_1497	COG0475	glutathione-regulated potassium exporter activity
AORI_1502	COG3424	synthase
AORI_1503	COG1024	Enoyl-CoA hydratase
AORI_1504	COG1024	Enoyl-CoA hydratase
AORI_1505	COG1024	Enoyl-CoA hydratase
AORI_1506	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AORI_1508	COG0667	Aldo Keto reductase
AORI_1524	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AORI_1525	COG1660	Displays ATPase and GTPase activities
AORI_1527	COG0726	polysaccharide deacetylase
AORI_1531	COG1937	Protein conserved in bacteria
AORI_1532	COG1937	Protein conserved in bacteria
AORI_1540	COG2197	response regulator
AORI_1543	COG2124	cytochrome p450
AORI_1549	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_1549	COG2319	Wd-40 repeat
AORI_1557	COG0789	Transcriptional regulator
AORI_1560	COG1309	transcriptional regulator
AORI_1563	COG0179	Fumarylacetoacetate (FAA) hydrolase
AORI_1564	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_1572	COG2304	oxidoreductase activity
AORI_1577	COG2226	methyltransferase
AORI_1602	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_1603	COG0765	amino acid transport
AORI_1607	COG0596	Alpha beta hydrolase
AORI_1608	COG1131	(ABC) transporter
AORI_1621	COG4991	sh3 domain protein
AORI_1622	COG3903	Transcriptional regulator
AORI_1622	COG3629	intracellular signal transduction
AORI_1623	COG4991	sh3 domain protein
AORI_1624	COG3540	Alkaline phosphatase
AORI_1626	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AORI_1627	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AORI_1631	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AORI_1633	COG0513	Belongs to the DEAD box helicase family
AORI_1636	COG2183	response to ionizing radiation
AORI_1639	COG2072	flavoprotein involved in K transport
AORI_1647	COG2030	dehydratase
AORI_1647	COG1012	belongs to the aldehyde dehydrogenase family
AORI_1648	COG3396	Phenylacetate-CoA oxygenase
AORI_1649	COG3460	Phenylacetate-CoA oxygenase
AORI_1650	COG3396	Phenylacetate-CoA oxygenase
AORI_1651	COG2151	metal-sulfur cluster biosynthetic enzyme
AORI_1652	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AORI_1653	COG0488	(ABC) transporter
AORI_1655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AORI_1655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AORI_1658	COG5002	protein histidine kinase activity
AORI_1660	COG1929	Belongs to the glycerate kinase type-1 family
AORI_1663	COG0542	response to heat
AORI_1664	COG1476	TRANSCRIPTIONal
AORI_1666	COG1131	(ABC) transporter
AORI_1667	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_1670	COG2197	response regulator
AORI_1671	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_1671	COG2319	Wd-40 repeat
AORI_1672	COG3973	AAA domain
AORI_1680	COG1797	cobyrinic acid a,c-diamide synthase activity
AORI_1683	COG0789	Transcriptional regulator
AORI_1685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AORI_1686	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AORI_1688	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AORI_1689	COG1492	cobalamin metabolic process
AORI_1692	COG1131	(ABC) transporter
AORI_1694	COG4585	Histidine kinase
AORI_1695	COG2197	response regulator
AORI_1700	COG0067	glutamate synthase
AORI_1700	COG0069	glutamate synthase activity
AORI_1700	COG0070	glutamate synthase
AORI_1702	COG1739	Uncharacterized protein family UPF0029
AORI_1705	COG1522	sequence-specific DNA binding
AORI_1707	COG0559	Belongs to the binding-protein-dependent transport system permease family
AORI_1708	COG0559	Belongs to the binding-protein-dependent transport system permease family
AORI_1710	COG0410	ABC transporter
AORI_1711	COG2197	response regulator
AORI_1713	COG0277	FAD linked oxidase domain protein
AORI_1713	COG0247	lactate metabolic process
AORI_1718	COG1309	transcriptional regulator
AORI_1721	COG4552	Acetyltransferase involved in intracellular survival and related
AORI_1722	COG0235	Class ii aldolase
AORI_1722	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AORI_1725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_1727	COG0010	Belongs to the arginase family
AORI_1728	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AORI_1729	COG3706	GGDEF domain
AORI_1733	COG1802	Transcriptional regulator
AORI_1735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AORI_1743	COG0475	glutathione-regulated potassium exporter activity
AORI_1745	COG1643	Atp-dependent helicase
AORI_1747	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_1757	COG1024	Enoyl-CoA hydratase
AORI_1766	COG1733	regulation of RNA biosynthetic process
AORI_1772	COG2205	protein histidine kinase activity
AORI_1772	COG2972	Histidine kinase
AORI_1773	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AORI_1774	COG1136	(ABC) transporter
AORI_1776	COG0745	RESPONSE REGULATOR receiver
AORI_1777	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AORI_1780	COG1609	Transcriptional regulator
AORI_1791	COG0596	Alpha beta hydrolase
AORI_1798	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AORI_1799	COG0581	inorganic phosphate transmembrane transporter activity
AORI_1806	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_1815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AORI_1817	COG4221	oxidoreductase activity
AORI_1818	COG2267	carboxylic ester hydrolase activity
AORI_1822	COG1937	Protein conserved in bacteria
AORI_1823	COG3795	YCII-related domain
AORI_1828	COG1733	regulation of RNA biosynthetic process
AORI_1829	COG3629	intracellular signal transduction
AORI_1832	COG1917	Cupin 2, conserved barrel domain protein
AORI_1832	COG4977	sequence-specific DNA binding
AORI_1836	COG2124	cytochrome p450
AORI_1843	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_1848	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_1852	COG2197	response regulator
AORI_1854	COG0009	L-threonylcarbamoyladenylate synthase
AORI_1855	COG1733	regulation of RNA biosynthetic process
AORI_1857	COG2197	response regulator
AORI_1859	COG1917	Cupin 2, conserved barrel domain protein
AORI_1859	COG4977	sequence-specific DNA binding
AORI_1861	COG2197	response regulator
AORI_1862	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_1868	COG1595	DNA-templated transcription, initiation
AORI_1870	COG1793	dna ligase
AORI_1870	COG3285	dna ligase
AORI_1871	COG1793	dna ligase
AORI_1871	COG3285	dna ligase
AORI_1873	COG1846	Transcriptional regulator
AORI_1875	COG1113	amino acid transport
AORI_1877	COG1733	regulation of RNA biosynthetic process
AORI_1879	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_1885	COG2197	response regulator
AORI_1887	COG0765	amino acid transport
AORI_1888	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AORI_1890	COG0540	Belongs to the ATCase OTCase family
AORI_1896	COG2022	thiamine diphosphate biosynthetic process
AORI_1901	COG1609	Transcriptional regulator
AORI_1911	COG2902	Dehydrogenase
AORI_1919	COG0668	transmembrane transport
AORI_1923	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AORI_1925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AORI_1928	COG0698	ribose 5-phosphate isomerase
AORI_1933	COG4941	Belongs to the sigma-70 factor family
AORI_1941	COG0784	Response regulator, receiver
AORI_1941	COG5002	protein histidine kinase activity
AORI_1944	COG0693	protein deglycase activity
AORI_1946	COG0515	serine threonine protein kinase
AORI_1946	COG2815	serine threonine protein kinase
AORI_1951	COG2814	Major facilitator Superfamily
AORI_1952	COG1846	Transcriptional regulator
AORI_1958	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_1959	COG1215	transferase activity, transferring glycosyl groups
AORI_1960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_1961	COG2205	protein histidine kinase activity
AORI_1962	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AORI_1963	COG0544	peptidyl-prolyl cis-trans isomerase activity
AORI_1966	COG0740	serine-type endopeptidase activity
AORI_1973	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AORI_1976	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_1977	COG1316	TRANSCRIPTIONal
AORI_1982	COG0525	valine-tRNA ligase activity
AORI_1985	COG0285	dihydrofolate synthase activity
AORI_1987	COG1403	HNH endonuclease
AORI_1990	COG1733	regulation of RNA biosynthetic process
AORI_1991	COG0105	UTP biosynthetic process
AORI_1995	COG1131	(ABC) transporter
AORI_1997	COG0842	Transport permease protein
AORI_2000	COG1530	ribonuclease E activity
AORI_2001	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AORI_2002	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AORI_2003	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AORI_2009	COG0018	arginyl-trna synthetase
AORI_2010	COG0477	Major facilitator Superfamily
AORI_2012	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AORI_2013	COG0799	negative regulation of ribosome biogenesis
AORI_2014	COG0406	alpha-ribazole phosphatase activity
AORI_2016	COG1307	EDD domain protein, DegV family
AORI_2017	COG1555	photosystem II stabilization
AORI_2018	COG0658	competence protein
AORI_2018	COG2333	competence protein COMEC
AORI_2021	COG0268	Binds directly to 16S ribosomal RNA
AORI_2024	COG2226	methyltransferase
AORI_2025	COG0481	GTPase activity
AORI_2028	COG2070	2-Nitropropane dioxygenase
AORI_2029	COG0531	amino acid
AORI_2031	COG0604	alcohol dehydrogenase
AORI_2034	COG2732	(Barnase) inhibitor
AORI_2048	COG2192	nodulation
AORI_2050	COG0463	Glycosyl transferase, family 2
AORI_2060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_2062	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_2064	COG1953	Uracil, thiamine, allantoin
AORI_2065	COG0745	RESPONSE REGULATOR receiver
AORI_2066	COG2205	protein histidine kinase activity
AORI_2073	COG1420	regulation of RNA biosynthetic process
AORI_2074	COG0484	heat shock protein binding
AORI_2076	COG0537	adenosine 5'-monophosphoramidase activity
AORI_2078	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AORI_2081	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AORI_2088	COG1381	Involved in DNA repair and RecF pathway recombination
AORI_2089	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AORI_2091	COG0701	Predicted permease
AORI_2098	COG0423	glycine-tRNA ligase activity
AORI_2099	COG1131	(ABC) transporter
AORI_2101	COG4585	Histidine kinase
AORI_2102	COG2197	response regulator
AORI_2104	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AORI_2107	COG1012	belongs to the aldehyde dehydrogenase family
AORI_2108	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_2109	COG1595	DNA-templated transcription, initiation
AORI_2112	COG4106	trans-aconitate 2-methyltransferase activity
AORI_2119	COG1733	regulation of RNA biosynthetic process
AORI_2128	COG0702	epimerase
AORI_2131	COG3903	Transcriptional regulator
AORI_2131	COG3629	intracellular signal transduction
AORI_2135	COG0531	amino acid
AORI_2136	COG3647	Membrane
AORI_2139	COG2508	Transcriptional regulator
AORI_2140	COG2072	flavoprotein involved in K transport
AORI_2148	COG3629	intracellular signal transduction
AORI_2148	COG3903	Transcriptional regulator
AORI_2149	COG2223	nitrite transmembrane transporter activity
AORI_2150	COG2207	Transcriptional regulator
AORI_2154	COG0137	argininosuccinate synthase activity
AORI_2165	COG0702	epimerase
AORI_2167	COG3850	Histidine kinase
AORI_2167	COG5002	protein histidine kinase activity
AORI_2176	COG4974	Belongs to the 'phage' integrase family
AORI_2178	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_2192	COG1316	TRANSCRIPTIONal
AORI_2195	COG1960	acyl-CoA dehydrogenase activity
AORI_2196	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_2198	COG1024	Enoyl-CoA hydratase
AORI_2199	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AORI_2200	COG0583	DNA-binding transcription factor activity
AORI_2201	COG5002	protein histidine kinase activity
AORI_2202	COG0745	RESPONSE REGULATOR receiver
AORI_2204	COG2936	dipeptidyl-peptidase activity
AORI_2207	COG1733	regulation of RNA biosynthetic process
AORI_2215	COG0779	Required for maturation of 30S ribosomal subunits
AORI_2220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AORI_2224	COG0201	protein transport
AORI_2226	COG3629	intracellular signal transduction
AORI_2226	COG3903	Transcriptional regulator
AORI_2230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AORI_2234	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AORI_2235	COG1185	polyribonucleotide nucleotidyltransferase activity
AORI_2236	COG0612	Peptidase, M16
AORI_2237	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AORI_2242	COG3214	Protein conserved in bacteria
AORI_2248	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_2249	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AORI_2250	COG1113	amino acid transport
AORI_2256	COG0655	NAD(P)H dehydrogenase (quinone) activity
AORI_2258	COG1674	ftsk spoiiie
AORI_2261	COG0596	Alpha beta hydrolase
AORI_2263	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AORI_2264	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AORI_2266	COG1546	Belongs to the CinA family
AORI_2266	COG1058	Belongs to the CinA family
AORI_2267	COG1396	sequence-specific DNA binding
AORI_2272	COG0154	amidase activity
AORI_2273	COG0167	dihydroorotate dehydrogenase activity
AORI_2275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AORI_2276	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AORI_2277	COG1192	Involved in chromosome partitioning
AORI_2279	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AORI_2281	COG1305	Transglutaminase-like
AORI_2283	COG0714	Associated with various cellular activities
AORI_2289	COG2001	Belongs to the MraZ family
AORI_2290	COG0275	rRNA processing
AORI_2292	COG0768	penicillin binding
AORI_2295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AORI_2296	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AORI_2298	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AORI_2299	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AORI_2300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AORI_2325	COG0242	peptide deformylase activity
AORI_2326	COG1201	RNA secondary structure unwinding
AORI_2327	COG0443	Heat shock 70 kDa protein
AORI_2329	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AORI_2330	COG2137	regulation of response to DNA damage stimulus
AORI_2334	COG0800	Aldolase
AORI_2338	COG1053	succinate dehydrogenase
AORI_2340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_2341	COG0765	amino acid transport
AORI_2342	COG0765	amino acid transport
AORI_2343	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_2344	COG1126	abc transporter atp-binding protein
AORI_2345	COG0745	RESPONSE REGULATOR receiver
AORI_2346	COG2205	protein histidine kinase activity
AORI_2348	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AORI_2351	COG1196	nuclear chromosome segregation
AORI_2353	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AORI_2357	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AORI_2359	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AORI_2361	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AORI_2369	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AORI_2370	COG2076	Multidrug Resistance protein
AORI_2371	COG1505	serine-type exopeptidase activity
AORI_2376	COG2936	dipeptidyl-peptidase activity
AORI_2380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AORI_2383	COG0123	including yeast histone deacetylase and acetoin utilization protein
AORI_2386	COG1309	transcriptional regulator
AORI_2388	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_2389	COG1960	acyl-CoA dehydrogenase activity
AORI_2390	COG1960	acyl-CoA dehydrogenase activity
AORI_2392	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_2394	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_2395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_2405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_2413	COG0003	Pfam Anion-transporting ATPase
AORI_2415	COG1940	carbohydrate kinase activity
AORI_2417	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_2422	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AORI_2424	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_2428	COG0640	Transcriptional regulator
AORI_2432	COG1946	Acyl-CoA thioesterase
AORI_2436	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_2436	COG1672	PFAM Archaeal ATPase
AORI_2437	COG1012	belongs to the aldehyde dehydrogenase family
AORI_2441	COG1960	acyl-CoA dehydrogenase activity
AORI_2442	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AORI_2444	COG1024	Enoyl-CoA hydratase
AORI_2448	COG1566	PFAM secretion protein HlyD family protein
AORI_2449	COG2814	Major facilitator Superfamily
AORI_2452	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_2455	COG2018	Roadblock/LC7 domain
AORI_2461	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AORI_2461	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AORI_2461	COG1703	isobutyryl-CoA mutase activity
AORI_2463	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_2464	COG1309	transcriptional regulator
AORI_2465	COG1960	acyl-CoA dehydrogenase activity
AORI_2466	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AORI_2470	COG1960	acyl-CoA dehydrogenase activity
AORI_2471	COG1960	acyl-CoA dehydrogenase activity
AORI_2474	COG0183	Belongs to the thiolase family
AORI_2476	COG0196	riboflavin kinase activity
AORI_2482	COG1053	succinate dehydrogenase
AORI_2484	COG1960	acyl-CoA dehydrogenase activity
AORI_2485	COG2267	carboxylic ester hydrolase activity
AORI_2486	COG0346	lactoylglutathione lyase activity
AORI_2487	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AORI_2495	COG1960	acyl-CoA dehydrogenase activity
AORI_2496	COG1960	acyl-CoA dehydrogenase activity
AORI_2497	COG1960	acyl-CoA dehydrogenase activity
AORI_2498	COG1024	Enoyl-CoA hydratase
AORI_2499	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_2500	COG1960	acyl-CoA dehydrogenase activity
AORI_2501	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_2502	COG1309	transcriptional regulator
AORI_2503	COG0183	Belongs to the thiolase family
AORI_2504	COG2814	Major facilitator Superfamily
AORI_2506	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AORI_2514	COG0110	maltose O-acetyltransferase activity
AORI_2517	COG0596	Alpha beta hydrolase
AORI_2521	COG1024	Enoyl-CoA hydratase
AORI_2523	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_2527	COG0183	Belongs to the thiolase family
AORI_2528	COG2124	cytochrome p450
AORI_2530	COG1295	ribonuclease BN
AORI_2537	COG2070	2-Nitropropane dioxygenase
AORI_2539	COG2188	Transcriptional regulator
AORI_2540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_2541	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_2548	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AORI_2548	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AORI_2550	COG1490	D-aminoacyl-tRNA deacylase activity
AORI_2551	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_2555	COG2313	pseudouridylate synthase activity
AORI_2560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AORI_2563	COG4213	ABC transporter substrate-binding protein
AORI_2565	COG4214	carbohydrate transport
AORI_2568	COG0596	Alpha beta hydrolase
AORI_2573	COG0531	amino acid
AORI_2585	COG0483	inositol monophosphate 1-phosphatase activity
AORI_2589	COG0756	dUTP diphosphatase activity
AORI_2595	COG0569	domain protein
AORI_2596	COG0531	amino acid
AORI_2597	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AORI_2603	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AORI_2604	COG1309	transcriptional regulator
AORI_2605	COG0300	oxidoreductase activity
AORI_2607	COG1012	belongs to the aldehyde dehydrogenase family
AORI_2610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_2612	COG2801	Transposase and inactivated derivatives
AORI_2612	COG3415	Transposase
AORI_2613	COG0745	RESPONSE REGULATOR receiver
AORI_2614	COG2205	protein histidine kinase activity
AORI_2615	COG0656	L-ascorbic acid biosynthetic process
AORI_2617	COG1024	Enoyl-CoA hydratase
AORI_2617	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_2618	COG0183	Belongs to the thiolase family
AORI_2623	COG3665	Urea carboxylase-associated protein
AORI_2626	COG1309	transcriptional regulator
AORI_2628	COG2197	response regulator
AORI_2630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AORI_2633	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AORI_2637	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AORI_2641	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_2644	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_2645	COG0539	negative regulation of cytoplasmic translation
AORI_2646	COG2508	Transcriptional regulator
AORI_2646	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_2647	COG1012	belongs to the aldehyde dehydrogenase family
AORI_2648	COG0506	proline dehydrogenase activity
AORI_2649	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AORI_2652	COG1793	dna ligase
AORI_2659	COG1595	DNA-templated transcription, initiation
AORI_2663	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_2665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AORI_2666	COG2326	polyphosphate kinase activity
AORI_2669	COG0446	pyridine nucleotide-disulphide oxidoreductase
AORI_2671	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AORI_2672	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AORI_2678	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AORI_2689	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AORI_2691	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AORI_2692	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AORI_2693	COG0235	Class ii aldolase
AORI_2694	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AORI_2700	COG1215	transferase activity, transferring glycosyl groups
AORI_2703	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AORI_2706	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AORI_2707	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AORI_2712	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AORI_2714	COG3842	ATPase activity
AORI_2715	COG1178	ABC-type Fe3 transport system permease component
AORI_2718	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AORI_2719	COG1263	PTS System
AORI_2719	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AORI_2719	COG2190	(PTS) system
AORI_2721	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AORI_2721	COG1263	PTS System
AORI_2728	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AORI_2729	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AORI_2731	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AORI_2732	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AORI_2733	COG0346	lactoylglutathione lyase activity
AORI_2736	COG0006	proline dipeptidase activity
AORI_2737	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AORI_2738	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AORI_2740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AORI_2741	COG0540	Belongs to the ATCase OTCase family
AORI_2744	COG0505	Belongs to the CarA family
AORI_2746	COG0284	orotidine-5'-phosphate decarboxylase activity
AORI_2748	COG0194	GDP metabolic process
AORI_2749	COG1758	RNA polymerase activity
AORI_2751	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AORI_2752	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AORI_2754	COG0405	Gamma-glutamyltransferase
AORI_2755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AORI_2759	COG2197	response regulator
AORI_2760	COG4585	Histidine kinase
AORI_2763	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AORI_2763	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AORI_2764	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AORI_2768	COG0322	excinuclease ABC activity
AORI_2769	COG1660	Displays ATPase and GTPase activities
AORI_2771	COG1481	regulation of sporulation
AORI_2774	COG0463	Glycosyl transferase, family 2
AORI_2776	COG1309	transcriptional regulator
AORI_2777	COG3250	beta-galactosidase activity
AORI_2785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AORI_2786	COG0126	phosphoglycerate kinase activity
AORI_2787	COG0149	triose-phosphate isomerase activity
AORI_2791	COG0363	glucosamine-6-phosphate deaminase activity
AORI_2794	COG0166	Belongs to the GPI family
AORI_2795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AORI_2797	COG0109	protoheme IX farnesyltransferase activity
AORI_2806	COG1612	heme a metabolic process
AORI_2813	COG0396	ATPase activity
AORI_2816	COG2151	metal-sulfur cluster biosynthetic enzyme
AORI_2817	COG1742	UPF0060 membrane protein
AORI_2820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AORI_2823	COG4585	Histidine kinase
AORI_2824	COG2197	response regulator
AORI_2826	COG0175	sulfate reduction
AORI_2832	COG2200	EAL domain
AORI_2832	COG2199	diguanylate cyclase activity
AORI_2834	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AORI_2837	COG0488	(ABC) transporter
AORI_2840	COG1132	(ABC) transporter
AORI_2842	COG4821	SIS domain
AORI_2843	COG2267	carboxylic ester hydrolase activity
AORI_2844	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_2845	COG1316	TRANSCRIPTIONal
AORI_2850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AORI_2852	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AORI_2852	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AORI_2854	COG1024	Enoyl-CoA hydratase
AORI_2859	COG1309	transcriptional regulator
AORI_2862	COG1960	acyl-CoA dehydrogenase activity
AORI_2863	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_2867	COG1309	transcriptional regulator
AORI_2872	COG3469	chitinase activity
AORI_2873	COG0745	RESPONSE REGULATOR receiver
AORI_2873	COG3706	GGDEF domain
AORI_2876	COG0477	Major facilitator Superfamily
AORI_2878	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_2882	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_2884	COG1309	transcriptional regulator
AORI_2885	COG1960	acyl-CoA dehydrogenase activity
AORI_2886	COG1960	acyl-CoA dehydrogenase activity
AORI_2887	COG1960	acyl-CoA dehydrogenase activity
AORI_2891	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AORI_2892	COG0717	Belongs to the dCTP deaminase family
AORI_2901	COG0484	heat shock protein binding
AORI_2905	COG0531	amino acid
AORI_2906	COG1940	carbohydrate kinase activity
AORI_2907	COG0431	NADPH-dependent FMN reductase
AORI_2911	COG2124	cytochrome p450
AORI_2916	COG0564	pseudouridine synthase activity
AORI_2918	COG3903	Transcriptional regulator
AORI_2918	COG3629	intracellular signal transduction
AORI_2919	COG3629	intracellular signal transduction
AORI_2919	COG3903	Transcriptional regulator
AORI_2923	COG3903	Transcriptional regulator
AORI_2923	COG3629	intracellular signal transduction
AORI_2935	COG2197	response regulator
AORI_2939	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_2942	COG0156	8-amino-7-oxononanoate synthase activity
AORI_2943	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_2958	COG1280	lysine exporter protein (LysE YggA)
AORI_2959	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_2965	COG4977	sequence-specific DNA binding
AORI_2968	COG1116	anion transmembrane transporter activity
AORI_2969	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AORI_2970	COG0601	transmembrane transport
AORI_2971	COG4166	transmembrane transport
AORI_2974	COG0025	NhaP-type Na H and K H
AORI_2980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AORI_2981	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AORI_2982	COG2197	response regulator
AORI_2983	COG4585	Histidine kinase
AORI_2986	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AORI_2996	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_2997	COG1309	transcriptional regulator
AORI_2998	COG1414	Transcriptional regulator
AORI_2999	COG3734	2-keto-3-deoxy-galactonokinase
AORI_3000	COG0800	Aldolase
AORI_3001	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_3002	COG2271	Major facilitator Superfamily
AORI_3003	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_3005	COG1595	DNA-templated transcription, initiation
AORI_3006	COG0666	response to abiotic stimulus
AORI_3008	COG4585	Histidine kinase
AORI_3009	COG2197	response regulator
AORI_3010	COG0667	Aldo Keto reductase
AORI_3016	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_3021	COG2610	gluconate transmembrane transporter activity
AORI_3023	COG0473	3-isopropylmalate dehydrogenase activity
AORI_3028	COG0604	alcohol dehydrogenase
AORI_3036	COG0583	DNA-binding transcription factor activity
AORI_3038	COG1819	glycosyl
AORI_3039	COG2197	response regulator
AORI_3042	COG2197	response regulator
AORI_3052	COG1131	(ABC) transporter
AORI_3054	COG2197	response regulator
AORI_3059	COG0789	Transcriptional regulator
AORI_3068	COG2124	cytochrome p450
AORI_3070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AORI_3071	COG0463	Glycosyl transferase, family 2
AORI_3072	COG2195	Cleaves the N-terminal amino acid of tripeptides
AORI_3074	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_3075	COG3795	YCII-related domain
AORI_3076	COG4941	Belongs to the sigma-70 factor family
AORI_3077	COG1349	DNA-binding transcription factor activity
AORI_3081	COG3706	GGDEF domain
AORI_3082	COG2814	Major facilitator Superfamily
AORI_3089	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AORI_3090	COG0328	RNA-DNA hybrid ribonuclease activity
AORI_3093	COG2205	protein histidine kinase activity
AORI_3094	COG0745	RESPONSE REGULATOR receiver
AORI_3096	COG3706	GGDEF domain
AORI_3098	COG3903	Transcriptional regulator
AORI_3098	COG3629	intracellular signal transduction
AORI_3100	COG0697	spore germination
AORI_3107	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_3110	COG1733	regulation of RNA biosynthetic process
AORI_3112	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_3113	COG1053	succinate dehydrogenase
AORI_3116	COG0154	amidase activity
AORI_3117	COG1414	Transcriptional regulator
AORI_3118	COG0515	serine threonine protein kinase
AORI_3118	COG2815	serine threonine protein kinase
AORI_3120	COG2124	cytochrome p450
AORI_3122	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_3123	COG1733	regulation of RNA biosynthetic process
AORI_3124	COG1309	transcriptional regulator
AORI_3125	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3126	COG0028	Belongs to the TPP enzyme family
AORI_3138	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_3140	COG1573	uracil-dna glycosylase
AORI_3142	COG3655	Transcriptional regulator
AORI_3150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_3150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_3156	COG0017	Asparaginyl-tRNA synthetase
AORI_3157	COG0069	glutamate synthase activity
AORI_3164	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AORI_3165	COG1834	amidinotransferase
AORI_3166	COG0475	glutathione-regulated potassium exporter activity
AORI_3168	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3169	COG0859	PFAM glycosyl transferase family 9
AORI_3177	COG0704	Plays a role in the regulation of phosphate uptake
AORI_3182	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_3184	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3185	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AORI_3185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AORI_3186	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AORI_3187	COG2192	nodulation
AORI_3188	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_3192	COG0438	transferase activity, transferring glycosyl groups
AORI_3195	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_3198	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_3199	COG0723	plastoquinol--plastocyanin reductase activity
AORI_3200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AORI_3204	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_3210	COG3903	Transcriptional regulator
AORI_3210	COG3629	intracellular signal transduction
AORI_3215	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AORI_3216	COG1335	isochorismatase
AORI_3225	COG2356	endonuclease I
AORI_3226	COG0456	acetyltransferase
AORI_3230	COG3345	alpha-galactosidase
AORI_3234	COG1222	aaa ATPase
AORI_3254	COG2197	response regulator
AORI_3262	COG0300	oxidoreductase activity
AORI_3262	COG3321	synthase
AORI_3262	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_3262	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_3262	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3263	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_3263	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_3271	COG1473	amidohydrolase
AORI_3272	COG0477	Major facilitator Superfamily
AORI_3278	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3279	COG0531	amino acid
AORI_3283	COG1131	(ABC) transporter
AORI_3286	COG3835	regulator
AORI_3287	COG3835	regulator
AORI_3290	COG2814	Major facilitator Superfamily
AORI_3292	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3301	COG2197	response regulator
AORI_3307	COG3629	intracellular signal transduction
AORI_3307	COG3903	Transcriptional regulator
AORI_3308	COG0736	holo-[acyl-carrier-protein] synthase activity
AORI_3311	COG0736	holo-[acyl-carrier-protein] synthase activity
AORI_3313	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AORI_3317	COG0736	holo-[acyl-carrier-protein] synthase activity
AORI_3319	COG4585	Histidine kinase
AORI_3320	COG2197	response regulator
AORI_3321	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3327	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_3327	COG2319	Wd-40 repeat
AORI_3331	COG1672	PFAM Archaeal ATPase
AORI_3331	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_3335	COG1674	ftsk spoiiie
AORI_3352	COG2255	four-way junction helicase activity
AORI_3353	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_3357	COG1960	acyl-CoA dehydrogenase activity
AORI_3360	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AORI_3361	COG1012	belongs to the aldehyde dehydrogenase family
AORI_3363	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AORI_3364	COG1522	sequence-specific DNA binding
AORI_3365	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_3366	COG3268	Saccharopine dehydrogenase
AORI_3367	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3373	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AORI_3373	COG3291	Pkd domain containing protein
AORI_3376	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_3381	COG0583	DNA-binding transcription factor activity
AORI_3388	COG0702	epimerase
AORI_3402	COG0596	Alpha beta hydrolase
AORI_3405	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_3407	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_3414	COG2132	Multicopper oxidase
AORI_3416	COG0583	DNA-binding transcription factor activity
AORI_3423	COG2814	Major facilitator Superfamily
AORI_3428	COG3629	intracellular signal transduction
AORI_3428	COG3903	Transcriptional regulator
AORI_3439	COG0673	inositol 2-dehydrogenase activity
AORI_3455	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AORI_3456	COG0714	Associated with various cellular activities
AORI_3460	COG3226	Transcriptional regulator
AORI_3465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AORI_3470	COG0277	FAD linked oxidase domain protein
AORI_3471	COG0583	DNA-binding transcription factor activity
AORI_3474	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_3478	COG1609	Transcriptional regulator
AORI_3482	COG1609	Transcriptional regulator
AORI_3485	COG0395	ABC-type sugar transport system, permease component
AORI_3486	COG4209	transmembrane transport
AORI_3488	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AORI_3490	COG0596	Alpha beta hydrolase
AORI_3492	COG0667	Aldo Keto reductase
AORI_3495	COG0583	DNA-binding transcription factor activity
AORI_3501	COG1764	response to oxidative stress
AORI_3502	COG3903	Transcriptional regulator
AORI_3502	COG3629	intracellular signal transduction
AORI_3503	COG0366	Alpha amylase catalytic
AORI_3505	COG1175	transmembrane transport
AORI_3507	COG1609	Transcriptional regulator
AORI_3511	COG0477	Major facilitator Superfamily
AORI_3513	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AORI_3519	COG1414	Transcriptional regulator
AORI_3520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AORI_3521	COG0277	FAD linked oxidase domain protein
AORI_3523	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_3525	COG1309	transcriptional regulator
AORI_3526	COG2186	Transcriptional regulator
AORI_3528	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_3529	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AORI_3529	COG0825	malonyl-CoA metabolic process
AORI_3531	COG4977	sequence-specific DNA binding
AORI_3534	COG0745	RESPONSE REGULATOR receiver
AORI_3535	COG2205	protein histidine kinase activity
AORI_3537	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3538	COG1169	isochorismate synthase
AORI_3539	COG1021	2,3-dihydroxybenzoate-AMP ligase
AORI_3540	COG1535	isochorismatase
AORI_3540	COG3433	isochorismatase activity
AORI_3541	COG1535	isochorismatase
AORI_3541	COG3433	isochorismatase activity
AORI_3542	COG2375	cellular response to nickel ion
AORI_3543	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AORI_3544	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_3545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_3546	COG1120	ATPase activity
AORI_3549	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AORI_3562	COG0701	Predicted permease
AORI_3564	COG5504	Zn-dependent protease
AORI_3566	COG1802	Transcriptional regulator
AORI_3567	COG1012	belongs to the aldehyde dehydrogenase family
AORI_3572	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_3576	COG0601	transmembrane transport
AORI_3577	COG0747	negative chemotaxis
AORI_3582	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_3593	COG4977	sequence-specific DNA binding
AORI_3598	COG1253	flavin adenine dinucleotide binding
AORI_3599	COG0129	dihydroxy-acid dehydratase activity
AORI_3603	COG4585	Histidine kinase
AORI_3604	COG2197	response regulator
AORI_3606	COG1119	ATPase activity
AORI_3608	COG1366	Belongs to the anti-sigma-factor antagonist family
AORI_3613	COG0583	DNA-binding transcription factor activity
AORI_3614	COG0006	proline dipeptidase activity
AORI_3620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_3621	COG3938	Belongs to the proline racemase family
AORI_3622	COG0531	amino acid
AORI_3624	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_3626	COG0477	Major facilitator Superfamily
AORI_3634	COG1388	LysM domain
AORI_3634	COG3103	Sh3 type 3 domain protein
AORI_3634	COG0791	NLP P60 protein
AORI_3636	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_3646	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AORI_3647	COG2508	Transcriptional regulator
AORI_3647	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_3652	COG1295	ribonuclease BN
AORI_3664	COG1024	Enoyl-CoA hydratase
AORI_3666	COG0488	(ABC) transporter
AORI_3673	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AORI_3678	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AORI_3679	COG1132	(ABC) transporter
AORI_3680	COG1132	(ABC) transporter
AORI_3681	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_3682	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_3685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_3686	COG2801	Transposase and inactivated derivatives
AORI_3686	COG3415	Transposase
AORI_3694	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_3696	COG3568	Endonuclease Exonuclease Phosphatase
AORI_3700	COG0640	Transcriptional regulator
AORI_3704	COG0523	cobalamin synthesis protein
AORI_3706	COG0254	rRNA binding
AORI_3708	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AORI_3709	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AORI_3710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AORI_3713	COG1648	precorrin-2 dehydrogenase activity
AORI_3713	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AORI_3716	COG1024	Enoyl-CoA hydratase
AORI_3717	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_3729	COG0509	glycine decarboxylation via glycine cleavage system
AORI_3730	COG1716	ATPase activity
AORI_3735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_3735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_3738	COG0656	L-ascorbic acid biosynthetic process
AORI_3749	COG2267	carboxylic ester hydrolase activity
AORI_3750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AORI_3752	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_3753	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AORI_3754	COG0121	glutamine amidotransferase
AORI_3755	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AORI_3760	COG0477	Major facilitator Superfamily
AORI_3764	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AORI_3765	COG3883	PFAM NLP P60 protein
AORI_3765	COG0791	NLP P60 protein
AORI_3768	COG0714	Associated with various cellular activities
AORI_3770	COG2304	oxidoreductase activity
AORI_3771	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AORI_3773	COG3540	Alkaline phosphatase
AORI_3777	COG2205	protein histidine kinase activity
AORI_3778	COG0745	RESPONSE REGULATOR receiver
AORI_3779	COG0477	Major facilitator Superfamily
AORI_3781	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AORI_3786	COG1278	Cold shock
AORI_3787	COG3226	Transcriptional regulator
AORI_3788	COG0596	Alpha beta hydrolase
AORI_3792	COG4867	von Willebrand factor, type A
AORI_3793	COG0789	Transcriptional regulator
AORI_3794	COG0215	cysteine-tRNA ligase activity
AORI_3795	COG0488	(ABC) transporter
AORI_3798	COG2814	Major facilitator Superfamily
AORI_3801	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_3804	COG0140	phosphoribosyl-ATP diphosphatase activity
AORI_3805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AORI_3806	COG1192	Involved in chromosome partitioning
AORI_3809	COG0517	IMP dehydrogenase activity
AORI_3809	COG1994	Peptidase M50
AORI_3813	COG1222	aaa ATPase
AORI_3818	COG1051	belongs to the nudix hydrolase family
AORI_3821	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AORI_3822	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AORI_3826	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AORI_3831	COG4447	cellulose binding
AORI_3832	COG0640	Transcriptional regulator
AORI_3837	COG1733	regulation of RNA biosynthetic process
AORI_3839	COG2378	regulation of single-species biofilm formation
AORI_3841	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AORI_3843	COG1597	lipid kinase activity
AORI_3849	COG4552	Acetyltransferase involved in intracellular survival and related
AORI_3860	COG0583	DNA-binding transcription factor activity
AORI_3861	COG4221	oxidoreductase activity
AORI_3867	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_3868	COG2362	D-Aminopeptidase
AORI_3870	COG0488	(ABC) transporter
AORI_3874	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_3876	COG1595	DNA-templated transcription, initiation
AORI_3879	COG0183	Belongs to the thiolase family
AORI_3880	COG1733	regulation of RNA biosynthetic process
AORI_3887	COG0601	transmembrane transport
AORI_3893	COG1619	proteins homologs of microcin C7 resistance protein MccF
AORI_3903	COG0477	Major facilitator Superfamily
AORI_3904	COG0431	NADPH-dependent FMN reductase
AORI_3906	COG0640	Transcriptional regulator
AORI_3908	COG1309	transcriptional regulator
AORI_3915	COG1309	transcriptional regulator
AORI_3916	COG4585	Histidine kinase
AORI_3917	COG2197	response regulator
AORI_3919	COG0596	Alpha beta hydrolase
AORI_3921	COG0583	DNA-binding transcription factor activity
AORI_3922	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_3926	COG0590	tRNA wobble adenosine to inosine editing
AORI_3928	COG1522	sequence-specific DNA binding
AORI_3930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_3936	COG2226	methyltransferase
AORI_3938	COG1309	transcriptional regulator
AORI_3939	COG4974	Belongs to the 'phage' integrase family
AORI_3945	COG2755	lipolytic protein G-D-S-L family
AORI_3947	COG1357	PFAM Pentapeptide repeats (8 copies)
AORI_3951	COG0702	epimerase
AORI_3954	COG4941	Belongs to the sigma-70 factor family
AORI_3962	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AORI_3965	COG1960	acyl-CoA dehydrogenase activity
AORI_3966	COG1309	transcriptional regulator
AORI_3968	COG1595	DNA-templated transcription, initiation
AORI_3969	COG2318	DinB family
AORI_3971	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_3972	COG2226	methyltransferase
AORI_3973	COG2226	methyltransferase
AORI_3976	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AORI_3981	COG1435	thymidine kinase activity
AORI_3983	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_3989	COG0463	Glycosyl transferase, family 2
AORI_3991	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_3992	COG1509	lysine 2,3-aminomutase activity
AORI_3993	COG2814	Major facilitator Superfamily
AORI_3995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AORI_3996	COG0277	FAD linked oxidase domain protein
AORI_4002	COG0583	DNA-binding transcription factor activity
AORI_4004	COG3485	protocatechuate 3,4-dioxygenase
AORI_4006	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AORI_4007	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_4008	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AORI_4009	COG2423	ornithine cyclodeaminase activity
AORI_4013	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_4013	COG2508	Transcriptional regulator
AORI_4014	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_4016	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AORI_4020	COG2272	Belongs to the type-B carboxylesterase lipase family
AORI_4021	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AORI_4022	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AORI_4023	COG2080	2 iron, 2 sulfur cluster binding
AORI_4025	COG1309	transcriptional regulator
AORI_4026	COG0604	alcohol dehydrogenase
AORI_4026	COG3321	synthase
AORI_4026	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_4029	COG0028	Belongs to the TPP enzyme family
AORI_4036	COG0527	aspartate kinase activity
AORI_4040	COG4585	Histidine kinase
AORI_4041	COG2197	response regulator
AORI_4045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AORI_4046	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AORI_4058	COG0387	Pfam Sodium calcium exchanger
AORI_4059	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AORI_4063	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_4064	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_4064	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_4065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_4068	COG2226	methyltransferase
AORI_4070	COG1309	transcriptional regulator
AORI_4072	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AORI_4075	COG0697	spore germination
AORI_4078	COG2084	Dehydrogenase
AORI_4082	COG1136	(ABC) transporter
AORI_4083	COG1136	(ABC) transporter
AORI_4085	COG3537	Alpha-1,2-mannosidase
AORI_4086	COG0477	Major facilitator Superfamily
AORI_4089	COG1090	epimerase
AORI_4094	COG1846	Transcriptional regulator
AORI_4095	COG0039	L-malate dehydrogenase activity
AORI_4101	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_4102	COG1104	cysteine desulfurase activity
AORI_4103	COG0339	signal peptide processing
AORI_4105	COG1968	undecaprenyl-diphosphatase activity
AORI_4106	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_4107	COG0667	Aldo Keto reductase
AORI_4114	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_4115	COG0860	N-Acetylmuramoyl-L-alanine amidase
AORI_4115	COG3409	Peptidoglycan-binding domain 1 protein
AORI_4116	COG0739	heme binding
AORI_4119	COG3540	Alkaline phosphatase
AORI_4123	COG2197	response regulator
AORI_4124	COG4585	Histidine kinase
AORI_4127	COG0427	acetyl-CoA hydrolase
AORI_4133	COG3546	catalase activity
AORI_4136	COG1012	belongs to the aldehyde dehydrogenase family
AORI_4140	COG3404	Formiminotransferase-cyclodeaminase
AORI_4141	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AORI_4159	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_4167	COG2115	Belongs to the xylose isomerase family
AORI_4168	COG1940	carbohydrate kinase activity
AORI_4173	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_4177	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AORI_4179	COG0477	Major facilitator Superfamily
AORI_4184	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_4190	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_4191	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_4192	COG1129	ABC transporter
AORI_4193	COG1879	ABC-type sugar transport system periplasmic component
AORI_4194	COG1609	Transcriptional regulator
AORI_4195	COG4585	Histidine kinase
AORI_4196	COG2197	response regulator
AORI_4203	COG1136	(ABC) transporter
AORI_4203	COG0577	efflux transmembrane transporter activity
AORI_4204	COG0154	amidase activity
AORI_4205	COG0477	Major facilitator Superfamily
AORI_4207	COG4566	intracellular signal transduction
AORI_4208	COG0154	amidase activity
AORI_4214	COG4638	Rieske (2fe-2S)
AORI_4216	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_4222	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AORI_4224	COG0745	RESPONSE REGULATOR receiver
AORI_4227	COG4608	Belongs to the ABC transporter superfamily
AORI_4228	COG0444	Belongs to the ABC transporter superfamily
AORI_4234	COG2271	Major facilitator Superfamily
AORI_4235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_4235	COG2508	Transcriptional regulator
AORI_4236	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_4239	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AORI_4241	COG0395	ABC-type sugar transport system, permease component
AORI_4242	COG1175	transmembrane transport
AORI_4248	COG1733	regulation of RNA biosynthetic process
AORI_4250	COG1846	Transcriptional regulator
AORI_4253	COG2814	Major facilitator Superfamily
AORI_4254	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_4254	COG2755	lipolytic protein G-D-S-L family
AORI_4255	COG5002	protein histidine kinase activity
AORI_4256	COG0745	RESPONSE REGULATOR receiver
AORI_4260	COG0395	ABC-type sugar transport system, permease component
AORI_4261	COG1175	transmembrane transport
AORI_4262	COG1609	Transcriptional regulator
AORI_4263	COG0702	epimerase
AORI_4264	COG1846	Transcriptional regulator
AORI_4265	COG2409	Drug exporters of the RND superfamily
AORI_4274	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AORI_4281	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AORI_4284	COG0537	adenosine 5'-monophosphoramidase activity
AORI_4287	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AORI_4292	COG0477	Major facilitator Superfamily
AORI_4295	COG1012	belongs to the aldehyde dehydrogenase family
AORI_4297	COG3971	2-oxopent-4-enoate hydratase activity
AORI_4307	COG3250	beta-galactosidase activity
AORI_4308	COG3940	Belongs to the glycosyl hydrolase 43 family
AORI_4310	COG4214	carbohydrate transport
AORI_4311	COG1129	ABC transporter
AORI_4312	COG4213	ABC transporter substrate-binding protein
AORI_4313	COG2160	L-arabinose isomerase activity
AORI_4316	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_4317	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_4319	COG1879	ABC-type sugar transport system periplasmic component
AORI_4320	COG1609	Transcriptional regulator
AORI_4324	COG0395	ABC-type sugar transport system, permease component
AORI_4326	COG0488	(ABC) transporter
AORI_4329	COG4106	trans-aconitate 2-methyltransferase activity
AORI_4330	COG1309	transcriptional regulator
AORI_4332	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_4335	COG2814	Major facilitator Superfamily
AORI_4338	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_4339	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_4340	COG2197	response regulator
AORI_4342	COG4977	sequence-specific DNA binding
AORI_4351	COG2197	response regulator
AORI_4359	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AORI_4363	COG1522	sequence-specific DNA binding
AORI_4364	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AORI_4365	COG3285	dna ligase
AORI_4365	COG1793	dna ligase
AORI_4370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_4372	COG2366	antibiotic biosynthetic process
AORI_4376	COG3960	tartronate-semialdehyde synthase activity
AORI_4377	COG2084	Dehydrogenase
AORI_4378	COG3622	Belongs to the hyi family
AORI_4379	COG0596	Alpha beta hydrolase
AORI_4381	COG0596	Alpha beta hydrolase
AORI_4383	COG1280	lysine exporter protein (LysE YggA)
AORI_4386	COG3795	YCII-related domain
AORI_4388	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AORI_4392	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AORI_4396	COG2018	Roadblock/LC7 domain
AORI_4406	COG3903	Transcriptional regulator
AORI_4406	COG3629	intracellular signal transduction
AORI_4412	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_4413	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AORI_4414	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AORI_4415	COG0154	amidase activity
AORI_4416	COG1024	Enoyl-CoA hydratase
AORI_4417	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AORI_4418	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AORI_4419	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_4422	COG2255	four-way junction helicase activity
AORI_4423	COG0632	four-way junction helicase activity
AORI_4424	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AORI_4427	COG0217	transcriptional regulatory protein
AORI_4428	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AORI_4435	COG3629	intracellular signal transduction
AORI_4435	COG3903	Transcriptional regulator
AORI_4439	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AORI_4440	COG0277	FAD linked oxidase domain protein
AORI_4442	COG3608	succinylglutamate desuccinylase aspartoacylase
AORI_4442	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AORI_4444	COG0438	transferase activity, transferring glycosyl groups
AORI_4445	COG1560	Kdo2-lipid A biosynthetic process
AORI_4450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AORI_4451	COG0778	Nitroreductase
AORI_4468	COG3103	Sh3 type 3 domain protein
AORI_4468	COG1388	LysM domain
AORI_4468	COG0791	NLP P60 protein
AORI_4497	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AORI_4498	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AORI_4500	COG1051	belongs to the nudix hydrolase family
AORI_4502	COG0587	DNA-directed DNA polymerase activity
AORI_4509	COG0587	DNA-directed DNA polymerase activity
AORI_4514	COG3285	dna ligase
AORI_4514	COG1793	dna ligase
AORI_4524	COG3629	intracellular signal transduction
AORI_4524	COG3903	Transcriptional regulator
AORI_4530	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_4530	COG5479	isomerase activity
AORI_4555	COG3903	Transcriptional regulator
AORI_4555	COG3629	intracellular signal transduction
AORI_4558	COG0604	alcohol dehydrogenase
AORI_4563	COG3328	transposase activity
AORI_4574	COG0515	serine threonine protein kinase
AORI_4574	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AORI_4575	COG3903	Transcriptional regulator
AORI_4575	COG3629	intracellular signal transduction
AORI_4592	COG1017	nitric oxide dioxygenase activity
AORI_4592	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AORI_4594	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AORI_4599	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AORI_4599	COG0574	Belongs to the PEP-utilizing enzyme family
AORI_4600	COG0516	GMP reductase activity
AORI_4600	COG0517	IMP dehydrogenase activity
AORI_4610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AORI_4620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_4620	COG1042	CoA-binding domain protein
AORI_4620	COG0045	succinate-CoA ligase (ADP-forming) activity
AORI_4621	COG0517	IMP dehydrogenase activity
AORI_4624	COG0589	response to stress
AORI_4631	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AORI_4633	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AORI_4635	COG0516	GMP reductase activity
AORI_4635	COG0517	IMP dehydrogenase activity
AORI_4639	COG1470	cell adhesion involved in biofilm formation
AORI_4648	COG3903	Transcriptional regulator
AORI_4648	COG3629	intracellular signal transduction
AORI_4655	COG2319	Wd-40 repeat
AORI_4655	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_4660	COG2850	peptidyl-arginine hydroxylation
AORI_4670	COG1051	belongs to the nudix hydrolase family
AORI_4672	COG0477	Major facilitator Superfamily
AORI_4674	COG3903	Transcriptional regulator
AORI_4674	COG3629	intracellular signal transduction
AORI_4679	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_4683	COG2208	phosphoserine phosphatase activity
AORI_4683	COG2770	Histidine kinase
AORI_4687	COG1366	Belongs to the anti-sigma-factor antagonist family
AORI_4688	COG1366	Belongs to the anti-sigma-factor antagonist family
AORI_4689	COG2172	sigma factor antagonist activity
AORI_4703	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AORI_4706	COG0596	Alpha beta hydrolase
AORI_4710	COG2197	response regulator
AORI_4722	COG0798	PFAM Bile acid sodium symporter
AORI_4727	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_4727	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AORI_4730	COG1012	belongs to the aldehyde dehydrogenase family
AORI_4732	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_4733	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AORI_4734	COG0174	glutamine synthetase
AORI_4736	COG1607	acyl-coa hydrolase
AORI_4737	COG2072	flavoprotein involved in K transport
AORI_4745	COG1113	amino acid transport
AORI_4747	COG2855	membrane
AORI_4749	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AORI_4751	COG1414	Transcriptional regulator
AORI_4759	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AORI_4760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_4764	COG2197	response regulator
AORI_4768	COG1335	isochorismatase
AORI_4773	COG0477	Major facilitator Superfamily
AORI_4775	COG3473	Maleate cis-trans isomerase
AORI_4776	COG2309	aminopeptidase activity
AORI_4778	COG0778	Nitroreductase
AORI_4779	COG3903	Transcriptional regulator
AORI_4779	COG3629	intracellular signal transduction
AORI_4782	COG1733	regulation of RNA biosynthetic process
AORI_4792	COG1522	sequence-specific DNA binding
AORI_4794	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AORI_4797	COG0488	(ABC) transporter
AORI_4800	COG0488	(ABC) transporter
AORI_4802	COG0515	serine threonine protein kinase
AORI_4802	COG2815	serine threonine protein kinase
AORI_4806	COG0784	Response regulator, receiver
AORI_4807	COG4251	negative regulation of phosphorylation
AORI_4808	COG0745	RESPONSE REGULATOR receiver
AORI_4810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_4814	COG1819	glycosyl
AORI_4815	COG0300	oxidoreductase activity
AORI_4818	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_4819	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_4819	COG3321	synthase
AORI_4820	COG0477	Major facilitator Superfamily
AORI_4823	COG0515	serine threonine protein kinase
AORI_4823	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AORI_4824	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AORI_4824	COG0515	serine threonine protein kinase
AORI_4839	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AORI_4844	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_4851	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AORI_4855	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_4856	COG0667	Aldo Keto reductase
AORI_4857	COG2826	transposase and inactivated derivatives, IS30 family
AORI_4858	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_4861	COG1959	2 iron, 2 sulfur cluster binding
AORI_4863	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AORI_4864	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AORI_4866	COG1414	Transcriptional regulator
AORI_4867	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AORI_4872	COG3511	phospholipase C
AORI_4875	COG1335	isochorismatase
AORI_4878	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_4879	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_4879	COG2755	lipolytic protein G-D-S-L family
AORI_4880	COG2318	DinB family
AORI_4890	COG0583	DNA-binding transcription factor activity
AORI_4891	COG2814	Major facilitator Superfamily
AORI_4892	COG2076	Multidrug Resistance protein
AORI_4894	COG0583	DNA-binding transcription factor activity
AORI_4897	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_4897	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_4899	COG1309	transcriptional regulator
AORI_4909	COG2197	response regulator
AORI_4912	COG2072	flavoprotein involved in K transport
AORI_4913	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_4915	COG1309	transcriptional regulator
AORI_4917	COG2301	Belongs to the HpcH HpaI aldolase family
AORI_4918	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AORI_4920	COG1960	acyl-CoA dehydrogenase activity
AORI_4923	COG0477	Major facilitator Superfamily
AORI_4928	COG0861	Integral membrane protein TerC family
AORI_4931	COG1063	alcohol dehydrogenase
AORI_4932	COG0456	acetyltransferase
AORI_4932	COG0454	-acetyltransferase
AORI_4935	COG1132	(ABC) transporter
AORI_4936	COG1309	transcriptional regulator
AORI_4938	COG1064	alcohol dehydrogenase
AORI_4943	COG4106	trans-aconitate 2-methyltransferase activity
AORI_4945	COG2409	Drug exporters of the RND superfamily
AORI_4946	COG1309	transcriptional regulator
AORI_4950	COG3903	Transcriptional regulator
AORI_4950	COG3629	intracellular signal transduction
AORI_4951	COG2197	response regulator
AORI_4952	COG4585	Histidine kinase
AORI_4953	COG2315	Protein conserved in bacteria
AORI_4956	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_4957	COG0028	Belongs to the TPP enzyme family
AORI_4959	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_4960	COG1403	HNH endonuclease
AORI_4961	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AORI_4962	COG1595	DNA-templated transcription, initiation
AORI_4967	COG3629	intracellular signal transduction
AORI_4967	COG3903	Transcriptional regulator
AORI_4968	COG0596	Alpha beta hydrolase
AORI_4972	COG4991	sh3 domain protein
AORI_4978	COG0500	methyltransferase
AORI_4985	COG4981	capsule polysaccharide biosynthetic process
AORI_4989	COG5001	Diguanylate cyclase
AORI_4996	COG0596	Alpha beta hydrolase
AORI_4997	COG5492	domain, Protein
AORI_5000	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_5001	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_5003	COG1414	Transcriptional regulator
AORI_5004	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_5008	COG1846	Transcriptional regulator
AORI_5010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AORI_5014	COG3848	Pyruvate phosphate dikinase
AORI_5014	COG0574	Belongs to the PEP-utilizing enzyme family
AORI_5018	COG1160	GTP binding
AORI_5024	COG0475	glutathione-regulated potassium exporter activity
AORI_5025	COG2936	dipeptidyl-peptidase activity
AORI_5027	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AORI_5034	COG0504	CTP synthase activity
AORI_5035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AORI_5037	COG1802	Transcriptional regulator
AORI_5038	COG1953	Uracil, thiamine, allantoin
AORI_5043	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AORI_5046	COG0647	UMP catabolic process
AORI_5048	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AORI_5049	COG2094	Belongs to the DNA glycosylase MPG family
AORI_5052	COG0165	Argininosuccinate lyase
AORI_5054	COG1438	arginine binding
AORI_5055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AORI_5056	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AORI_5057	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AORI_5058	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AORI_5059	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AORI_5066	COG0072	phenylalanine-tRNA ligase activity
AORI_5066	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_5067	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AORI_5068	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_5069	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AORI_5070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AORI_5073	COG1802	Transcriptional regulator
AORI_5075	COG0251	oxidation-reduction process
AORI_5079	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AORI_5080	COG2610	gluconate transmembrane transporter activity
AORI_5081	COG2706	6-phosphogluconolactonase activity
AORI_5092	COG4565	transcriptional regulatory protein
AORI_5093	COG3290	protein histidine kinase activity
AORI_5094	COG1301	dicarboxylic acid transport
AORI_5096	COG1733	regulation of RNA biosynthetic process
AORI_5105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_5115	COG0789	Transcriptional regulator
AORI_5123	COG3012	SEC-C Motif Domain Protein
AORI_5124	COG3250	beta-galactosidase activity
AORI_5132	COG1070	Carbohydrate kinase
AORI_5133	COG1609	Transcriptional regulator
AORI_5137	COG1506	peptidase
AORI_5137	COG0823	Involved in the tonB-independent uptake of proteins
AORI_5137	COG4946	Tricorn protease homolog
AORI_5139	COG1131	(ABC) transporter
AORI_5142	COG1024	Enoyl-CoA hydratase
AORI_5149	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AORI_5149	COG0237	dephospho-CoA kinase activity
AORI_5151	COG0539	negative regulation of cytoplasmic translation
AORI_5152	COG2226	methyltransferase
AORI_5156	COG1511	domain protein
AORI_5159	COG1653	transport
AORI_5166	COG0583	DNA-binding transcription factor activity
AORI_5175	COG0583	DNA-binding transcription factor activity
AORI_5178	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AORI_5179	COG1501	Belongs to the glycosyl hydrolase 31 family
AORI_5180	COG1349	DNA-binding transcription factor activity
AORI_5183	COG0395	ABC-type sugar transport system, permease component
AORI_5187	COG1105	Belongs to the carbohydrate kinase PfkB family
AORI_5188	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_5192	COG2188	Transcriptional regulator
AORI_5196	COG2066	Belongs to the glutaminase family
AORI_5203	COG0583	DNA-binding transcription factor activity
AORI_5208	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AORI_5228	COG0411	ABC transporter
AORI_5229	COG0410	ABC transporter
AORI_5230	COG0559	Belongs to the binding-protein-dependent transport system permease family
AORI_5235	COG1846	Transcriptional regulator
AORI_5237	COG1902	pentaerythritol trinitrate reductase activity
AORI_5241	COG0740	serine-type endopeptidase activity
AORI_5242	COG0740	serine-type endopeptidase activity
AORI_5250	COG2197	response regulator
AORI_5252	COG3629	intracellular signal transduction
AORI_5252	COG3903	Transcriptional regulator
AORI_5253	COG3629	intracellular signal transduction
AORI_5253	COG3903	Transcriptional regulator
AORI_5258	COG0439	Biotin carboxylase
AORI_5260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AORI_5263	COG2855	membrane
AORI_5264	COG2814	Major facilitator Superfamily
AORI_5267	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_5267	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_5269	COG0739	heme binding
AORI_5274	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AORI_5278	COG1793	dna ligase
AORI_5280	COG0477	Major facilitator Superfamily
AORI_5281	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_5287	COG1846	Transcriptional regulator
AORI_5296	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_5303	COG1082	Xylose isomerase domain protein TIM barrel
AORI_5304	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_5306	COG0673	inositol 2-dehydrogenase activity
AORI_5315	COG1609	Transcriptional regulator
AORI_5316	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_5317	COG1024	Enoyl-CoA hydratase
AORI_5324	COG0165	Argininosuccinate lyase
AORI_5328	COG1024	Enoyl-CoA hydratase
AORI_5329	COG1024	Enoyl-CoA hydratase
AORI_5334	COG0475	glutathione-regulated potassium exporter activity
AORI_5339	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_5342	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_5349	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_5354	COG3903	Transcriptional regulator
AORI_5354	COG3629	intracellular signal transduction
AORI_5360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AORI_5361	COG1522	sequence-specific DNA binding
AORI_5365	COG0475	glutathione-regulated potassium exporter activity
AORI_5366	COG3033	Beta-eliminating lyase
AORI_5368	COG0596	Alpha beta hydrolase
AORI_5370	COG0484	heat shock protein binding
AORI_5373	COG0477	Major facilitator Superfamily
AORI_5375	COG1012	belongs to the aldehyde dehydrogenase family
AORI_5377	COG4221	oxidoreductase activity
AORI_5378	COG1309	transcriptional regulator
AORI_5380	COG2986	histidine ammonia-lyase
AORI_5382	COG0667	Aldo Keto reductase
AORI_5388	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_5394	COG0367	asparagine synthase
AORI_5401	COG0300	oxidoreductase activity
AORI_5402	COG0667	Aldo Keto reductase
AORI_5403	COG2124	cytochrome p450
AORI_5404	COG2197	response regulator
AORI_5410	COG0791	NLP P60 protein
AORI_5410	COG3883	PFAM NLP P60 protein
AORI_5414	COG1063	alcohol dehydrogenase
AORI_5417	COG2132	Multicopper oxidase
AORI_5435	COG1278	Cold shock
AORI_5438	COG2197	response regulator
AORI_5440	COG0604	alcohol dehydrogenase
AORI_5440	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_5440	COG3321	synthase
AORI_5442	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_5445	COG2986	histidine ammonia-lyase
AORI_5447	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AORI_5448	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_5449	COG0006	proline dipeptidase activity
AORI_5455	COG1674	ftsk spoiiie
AORI_5456	COG1404	Belongs to the peptidase S8 family
AORI_5461	COG0464	growth
AORI_5466	COG1113	amino acid transport
AORI_5467	COG2197	response regulator
AORI_5471	COG3903	Transcriptional regulator
AORI_5471	COG3629	intracellular signal transduction
AORI_5472	COG3903	Transcriptional regulator
AORI_5472	COG3629	intracellular signal transduction
AORI_5475	COG1175	transmembrane transport
AORI_5477	COG2197	response regulator
AORI_5480	COG1063	alcohol dehydrogenase
AORI_5485	COG3903	Transcriptional regulator
AORI_5485	COG3629	intracellular signal transduction
AORI_5491	COG0076	glutamate decarboxylase activity
AORI_5494	COG0076	glutamate decarboxylase activity
AORI_5496	COG2091	lysine biosynthetic process via aminoadipic acid
AORI_5502	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_5506	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_5507	COG2124	cytochrome p450
AORI_5511	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AORI_5516	COG0484	heat shock protein binding
AORI_5517	COG3285	dna ligase
AORI_5517	COG1793	dna ligase
AORI_5519	COG1733	regulation of RNA biosynthetic process
AORI_5521	COG1785	Belongs to the alkaline phosphatase family
AORI_5522	COG2197	response regulator
AORI_5523	COG4585	Histidine kinase
AORI_5525	COG1302	Protein conserved in bacteria
AORI_5532	COG1595	DNA-templated transcription, initiation
AORI_5536	COG0596	Alpha beta hydrolase
AORI_5538	COG1280	lysine exporter protein (LysE YggA)
AORI_5540	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AORI_5542	COG3903	Transcriptional regulator
AORI_5542	COG3629	intracellular signal transduction
AORI_5546	COG0789	Transcriptional regulator
AORI_5549	COG0640	Transcriptional regulator
AORI_5552	COG0596	Alpha beta hydrolase
AORI_5553	COG0494	nUDIX hydrolase
AORI_5564	COG0640	Transcriptional regulator
AORI_5565	COG0514	ATP-dependent DNA helicase (RecQ)
AORI_5567	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AORI_5571	COG0542	response to heat
AORI_5572	COG0477	Major facilitator Superfamily
AORI_5574	COG0667	Aldo Keto reductase
AORI_5576	COG0667	Aldo Keto reductase
AORI_5579	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AORI_5579	COG2010	Cytochrome c
AORI_5582	COG1940	carbohydrate kinase activity
AORI_5585	COG1309	transcriptional regulator
AORI_5589	COG0248	Ppx GppA phosphatase
AORI_5590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_5594	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AORI_5596	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AORI_5599	COG0640	Transcriptional regulator
AORI_5601	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AORI_5606	COG3599	regulation of cell shape
AORI_5608	COG1799	cell septum assembly
AORI_5609	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AORI_5613	COG1595	DNA-templated transcription, initiation
AORI_5616	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_5618	COG2318	DinB family
AORI_5620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AORI_5622	COG0596	Alpha beta hydrolase
AORI_5624	COG0069	glutamate synthase activity
AORI_5624	COG0070	glutamate synthase
AORI_5624	COG0067	glutamate synthase
AORI_5628	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AORI_5631	COG0174	glutamine synthetase
AORI_5632	COG0159	tryptophan synthase activity
AORI_5633	COG0133	tryptophan synthase activity
AORI_5634	COG0134	indole-3-glycerol-phosphate synthase activity
AORI_5636	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AORI_5640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AORI_5642	COG0107	imidazoleglycerol-phosphate synthase activity
AORI_5643	COG1309	transcriptional regulator
AORI_5653	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AORI_5654	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AORI_5656	COG1960	acyl-CoA dehydrogenase activity
AORI_5659	COG3958	Transketolase
AORI_5660	COG3959	Transketolase, thiamine diphosphate binding domain
AORI_5662	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AORI_5664	COG1309	transcriptional regulator
AORI_5665	COG2409	Drug exporters of the RND superfamily
AORI_5671	COG0131	Imidazoleglycerol-phosphate dehydratase
AORI_5672	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AORI_5673	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AORI_5675	COG3386	PFAM SMP-30 Gluconolaconase
AORI_5676	COG2197	response regulator
AORI_5686	COG1674	ftsk spoiiie
AORI_5688	COG3896	Chloramphenicol phosphotransferase-like protein
AORI_5697	COG1404	Belongs to the peptidase S8 family
AORI_5699	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AORI_5700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AORI_5702	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AORI_5706	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AORI_5707	COG0659	secondary active sulfate transmembrane transporter activity
AORI_5708	COG0659	secondary active sulfate transmembrane transporter activity
AORI_5709	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AORI_5710	COG2124	cytochrome p450
AORI_5713	COG0438	transferase activity, transferring glycosyl groups
AORI_5725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AORI_5727	COG2010	Cytochrome c
AORI_5728	COG1845	cytochrome c oxidase, subunit III
AORI_5735	COG0697	spore germination
AORI_5737	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AORI_5744	COG0667	Aldo Keto reductase
AORI_5746	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AORI_5749	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AORI_5751	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AORI_5755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AORI_5758	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AORI_5759	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_5762	COG1090	epimerase
AORI_5764	COG0321	lipoyl(octanoyl) transferase activity
AORI_5767	COG1309	transcriptional regulator
AORI_5770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AORI_5771	COG0586	Pfam SNARE associated Golgi protein
AORI_5772	COG1752	Esterase of the alpha-beta hydrolase superfamily
AORI_5774	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AORI_5776	COG0477	Major facilitator Superfamily
AORI_5777	COG0587	DNA-directed DNA polymerase activity
AORI_5782	COG1113	amino acid transport
AORI_5791	COG3226	Transcriptional regulator
AORI_5792	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_5800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AORI_5802	COG3201	nicotinamide mononucleotide transporter
AORI_5803	COG0668	transmembrane transport
AORI_5805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AORI_5806	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AORI_5809	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AORI_5814	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AORI_5816	COG0095	Lipoate-protein ligase
AORI_5817	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AORI_5818	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AORI_5819	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AORI_5825	COG2197	response regulator
AORI_5826	COG1660	Displays ATPase and GTPase activities
AORI_5828	COG1396	sequence-specific DNA binding
AORI_5834	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AORI_5835	COG0442	prolyl-tRNA aminoacylation
AORI_5839	COG0456	acetyltransferase
AORI_5840	COG3022	response to hydroperoxide
AORI_5844	COG1404	Belongs to the peptidase S8 family
AORI_5848	COG0513	Belongs to the DEAD box helicase family
AORI_5849	COG0156	8-amino-7-oxononanoate synthase activity
AORI_5855	COG2807	transmembrane transport
AORI_5856	COG2186	Transcriptional regulator
AORI_5858	COG0768	penicillin binding
AORI_5859	COG0456	acetyltransferase
AORI_5859	COG0454	-acetyltransferase
AORI_5860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AORI_5861	COG0750	zinc metalloprotease
AORI_5862	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AORI_5865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AORI_5871	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_5871	COG2755	lipolytic protein G-D-S-L family
AORI_5873	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_5875	COG2124	cytochrome p450
AORI_5880	COG1476	TRANSCRIPTIONal
AORI_5881	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_5881	COG3321	synthase
AORI_5881	COG0604	alcohol dehydrogenase
AORI_5882	COG3540	Alkaline phosphatase
AORI_5897	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AORI_5898	COG1695	Transcriptional regulator
AORI_5904	COG0528	UMP kinase activity
AORI_5905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AORI_5906	COG0052	Belongs to the universal ribosomal protein uS2 family
AORI_5908	COG1191	sigma factor activity
AORI_5911	COG0606	chelatase, subunit chli
AORI_5912	COG0792	nuclease activity
AORI_5914	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AORI_5915	COG0681	Belongs to the peptidase S26 family
AORI_5916	COG0335	large ribosomal subunit rRNA binding
AORI_5917	COG0336	Belongs to the RNA methyltransferase TrmD family
AORI_5920	COG0228	four-way junction DNA binding
AORI_5926	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AORI_5928	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AORI_5940	COG1832	CoA-binding protein
AORI_5941	COG4266	Belongs to the allantoicase family
AORI_5942	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_5945	COG2351	hydroxyisourate hydrolase activity
AORI_5948	COG1309	transcriptional regulator
AORI_5951	COG2252	PERMEase
AORI_5952	COG0590	tRNA wobble adenosine to inosine editing
AORI_5953	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AORI_5957	COG3835	regulator
AORI_5966	COG1414	Transcriptional regulator
AORI_5968	COG0477	Major facilitator Superfamily
AORI_5971	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AORI_5974	COG1254	Belongs to the acylphosphatase family
AORI_5978	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AORI_5979	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AORI_5980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AORI_5981	COG0367	asparagine synthase
AORI_5984	COG1131	(ABC) transporter
AORI_5985	COG1725	Transcriptional regulator
AORI_5986	COG3903	Transcriptional regulator
AORI_5986	COG3629	intracellular signal transduction
AORI_5988	COG0673	inositol 2-dehydrogenase activity
AORI_5989	COG1609	Transcriptional regulator
AORI_5990	COG1082	Xylose isomerase domain protein TIM barrel
AORI_5994	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AORI_5995	COG3718	enzyme involved in inositol metabolism
AORI_5996	COG3962	Belongs to the TPP enzyme family
AORI_6008	COG1522	sequence-specific DNA binding
AORI_6013	COG0667	Aldo Keto reductase
AORI_6016	COG1414	Transcriptional regulator
AORI_6017	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_6018	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AORI_6019	COG3485	protocatechuate 3,4-dioxygenase
AORI_6020	COG3485	protocatechuate 3,4-dioxygenase
AORI_6022	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AORI_6023	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AORI_6029	COG1929	Belongs to the glycerate kinase type-1 family
AORI_6033	COG2149	membrane
AORI_6039	COG2186	Transcriptional regulator
AORI_6040	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_6041	COG1129	ABC transporter
AORI_6044	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_6045	COG0179	Fumarylacetoacetate (FAA) hydrolase
AORI_6046	COG2814	Major facilitator Superfamily
AORI_6049	COG4221	oxidoreductase activity
AORI_6051	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_6052	COG1120	ATPase activity
AORI_6054	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_6056	COG2186	Transcriptional regulator
AORI_6057	COG1760	l-serine dehydratase
AORI_6058	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AORI_6059	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AORI_6060	COG0509	glycine decarboxylation via glycine cleavage system
AORI_6061	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AORI_6062	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_6062	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_6065	COG1012	belongs to the aldehyde dehydrogenase family
AORI_6066	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AORI_6067	COG0174	glutamine synthetase
AORI_6069	COG0017	Asparaginyl-tRNA synthetase
AORI_6072	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_6079	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AORI_6081	COG0571	ribonuclease III activity
AORI_6082	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AORI_6088	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AORI_6089	COG0742	ribosomal rna small subunit methyltransferase
AORI_6090	COG3973	AAA domain
AORI_6091	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_6091	COG2319	Wd-40 repeat
AORI_6092	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_6094	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_6099	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AORI_6109	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AORI_6110	COG1404	Belongs to the peptidase S8 family
AORI_6118	COG1461	Dihydroxyacetone kinase
AORI_6119	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AORI_6120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AORI_6121	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AORI_6128	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_6130	COG2205	protein histidine kinase activity
AORI_6131	COG0745	RESPONSE REGULATOR receiver
AORI_6136	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_6139	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AORI_6144	COG0776	regulation of translation
AORI_6145	COG0066	3-isopropylmalate dehydratase activity
AORI_6146	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AORI_6147	COG1414	Transcriptional regulator
AORI_6149	COG0745	RESPONSE REGULATOR receiver
AORI_6150	COG0464	growth
AORI_6152	COG0745	RESPONSE REGULATOR receiver
AORI_6153	COG2205	protein histidine kinase activity
AORI_6163	COG1674	ftsk spoiiie
AORI_6173	COG0714	Associated with various cellular activities
AORI_6186	COG1982	Orn Lys Arg decarboxylase major
AORI_6191	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AORI_6194	COG0534	Mate efflux family protein
AORI_6195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_6196	COG0019	diaminopimelate decarboxylase activity
AORI_6199	COG0583	DNA-binding transcription factor activity
AORI_6209	COG0640	Transcriptional regulator
AORI_6212	COG1012	belongs to the aldehyde dehydrogenase family
AORI_6213	COG2814	Major facilitator Superfamily
AORI_6218	COG1414	Transcriptional regulator
AORI_6223	COG0179	Fumarylacetoacetate (FAA) hydrolase
AORI_6224	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AORI_6225	COG0473	3-isopropylmalate dehydrogenase activity
AORI_6226	COG1404	Belongs to the peptidase S8 family
AORI_6236	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AORI_6237	COG0440	acetolactate synthase activity
AORI_6240	COG0129	dihydroxy-acid dehydratase activity
AORI_6249	COG0154	amidase activity
AORI_6250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AORI_6253	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AORI_6257	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_6258	COG0456	acetyltransferase
AORI_6259	COG0482	sulfurtransferase activity
AORI_6266	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AORI_6268	COG1307	EDD domain protein, DegV family
AORI_6270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_6272	COG0386	Belongs to the glutathione peroxidase family
AORI_6274	COG3250	beta-galactosidase activity
AORI_6282	COG0110	maltose O-acetyltransferase activity
AORI_6283	COG1957	nucleoside hydrolase
AORI_6284	COG0791	NLP P60 protein
AORI_6284	COG3883	PFAM NLP P60 protein
AORI_6290	COG1252	NADH dehydrogenase
AORI_6291	COG1595	DNA-templated transcription, initiation
AORI_6294	COG2272	Belongs to the type-B carboxylesterase lipase family
AORI_6295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AORI_6300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AORI_6318	COG2226	methyltransferase
AORI_6319	COG1024	Enoyl-CoA hydratase
AORI_6320	COG1119	ATPase activity
AORI_6328	COG0058	SHG alpha-glucan phosphorylase activity
AORI_6333	COG1846	Transcriptional regulator
AORI_6335	COG3537	Alpha-1,2-mannosidase
AORI_6336	COG1609	Transcriptional regulator
AORI_6342	COG3275	phosphorelay sensor kinase activity
AORI_6343	COG3279	Response regulator of the LytR AlgR family
AORI_6345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_6347	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_6349	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_6350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_6354	COG0183	Belongs to the thiolase family
AORI_6362	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_6363	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AORI_6366	COG2226	methyltransferase
AORI_6368	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AORI_6370	COG0433	COG0433 Predicted ATPase
AORI_6371	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AORI_6374	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_6386	COG0489	protein tyrosine kinase activity
AORI_6402	COG1024	Enoyl-CoA hydratase
AORI_6403	COG1309	transcriptional regulator
AORI_6404	COG0492	ferredoxin-NADP+ reductase activity
AORI_6408	COG0673	inositol 2-dehydrogenase activity
AORI_6410	COG2814	Major facilitator Superfamily
AORI_6411	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AORI_6413	COG2267	carboxylic ester hydrolase activity
AORI_6417	COG0698	ribose 5-phosphate isomerase
AORI_6420	COG3469	chitinase activity
AORI_6428	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AORI_6430	COG1408	metallophosphoesterase
AORI_6437	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_6439	COG2259	Doxx family
AORI_6440	COG2259	Doxx family
AORI_6443	COG2018	Roadblock/LC7 domain
AORI_6446	COG3844	kynureninase activity
AORI_6449	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_6452	COG3706	GGDEF domain
AORI_6454	COG1316	TRANSCRIPTIONal
AORI_6476	COG0587	DNA-directed DNA polymerase activity
AORI_6485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AORI_6486	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AORI_6488	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AORI_6491	COG1794	racemase activity, acting on amino acids and derivatives
AORI_6495	COG3191	aminopeptidase activity
AORI_6498	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AORI_6499	COG1335	isochorismatase
AORI_6500	COG0800	Aldolase
AORI_6508	COG0560	Phosphoserine phosphatase
AORI_6508	COG3830	Belongs to the UPF0237 family
AORI_6509	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AORI_6511	COG1819	glycosyl
AORI_6512	COG2267	carboxylic ester hydrolase activity
AORI_6516	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AORI_6520	COG0668	transmembrane transport
AORI_6522	COG0626	cystathionine gamma-synthase activity
AORI_6523	COG1522	sequence-specific DNA binding
AORI_6526	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_6528	COG1461	Dihydroxyacetone kinase
AORI_6529	COG2376	Dihydroxyacetone kinase
AORI_6537	COG1752	Esterase of the alpha-beta hydrolase superfamily
AORI_6539	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AORI_6542	COG4977	sequence-specific DNA binding
AORI_6544	COG1126	abc transporter atp-binding protein
AORI_6545	COG0765	amino acid transport
AORI_6546	COG0765	amino acid transport
AORI_6547	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_6551	COG1280	lysine exporter protein (LysE YggA)
AORI_6557	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AORI_6559	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AORI_6560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AORI_6561	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AORI_6562	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AORI_6563	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AORI_6564	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AORI_6565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AORI_6566	COG0356	it plays a direct role in the translocation of protons across the membrane
AORI_6568	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AORI_6572	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_6573	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AORI_6575	COG0596	Alpha beta hydrolase
AORI_6580	COG0254	rRNA binding
AORI_6583	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AORI_6583	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AORI_6584	COG0083	homoserine kinase activity
AORI_6585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AORI_6586	COG0460	homoserine dehydrogenase
AORI_6587	COG0019	diaminopimelate decarboxylase activity
AORI_6588	COG0018	arginyl-trna synthetase
AORI_6592	COG0596	Alpha beta hydrolase
AORI_6605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AORI_6607	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AORI_6608	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AORI_6610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AORI_6613	COG0183	Belongs to the thiolase family
AORI_6614	COG1960	acyl-CoA dehydrogenase activity
AORI_6615	COG1960	acyl-CoA dehydrogenase activity
AORI_6616	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_6618	COG2124	cytochrome p450
AORI_6619	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_6620	COG1215	transferase activity, transferring glycosyl groups
AORI_6621	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_6622	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_6624	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_6627	COG0644	oxidoreductase
AORI_6628	COG0475	glutathione-regulated potassium exporter activity
AORI_6629	COG1960	acyl-CoA dehydrogenase activity
AORI_6639	COG2197	response regulator
AORI_6646	COG2132	Multicopper oxidase
AORI_6648	COG4585	Histidine kinase
AORI_6649	COG2197	response regulator
AORI_6655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AORI_6656	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_6659	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_6660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_6663	COG1053	succinate dehydrogenase
AORI_6666	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_6670	COG4941	Belongs to the sigma-70 factor family
AORI_6673	COG1846	Transcriptional regulator
AORI_6676	COG2910	NAD(P)H-binding
AORI_6680	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_6681	COG1414	Transcriptional regulator
AORI_6685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AORI_6687	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_6693	COG0435	Glutathione S-transferase
AORI_6695	COG2133	pyrroloquinoline quinone binding
AORI_6696	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AORI_6700	COG0667	Aldo Keto reductase
AORI_6703	COG0154	amidase activity
AORI_6709	COG0473	3-isopropylmalate dehydrogenase activity
AORI_6714	COG3903	Transcriptional regulator
AORI_6714	COG3629	intracellular signal transduction
AORI_6717	COG0028	Belongs to the TPP enzyme family
AORI_6718	COG0477	Major facilitator Superfamily
AORI_6723	COG4585	Histidine kinase
AORI_6724	COG2197	response regulator
AORI_6725	COG2409	Drug exporters of the RND superfamily
AORI_6726	COG1024	Enoyl-CoA hydratase
AORI_6726	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_6727	COG0183	Belongs to the thiolase family
AORI_6728	COG1309	transcriptional regulator
AORI_6731	COG1960	acyl-CoA dehydrogenase activity
AORI_6734	COG4221	oxidoreductase activity
AORI_6737	COG1960	acyl-CoA dehydrogenase activity
AORI_6739	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_6740	COG2755	lipolytic protein G-D-S-L family
AORI_6743	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AORI_6745	COG0346	lactoylglutathione lyase activity
AORI_6746	COG1695	Transcriptional regulator
AORI_6748	COG2508	Transcriptional regulator
AORI_6748	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_6752	COG0686	Belongs to the AlaDH PNT family
AORI_6753	COG3629	intracellular signal transduction
AORI_6753	COG3903	Transcriptional regulator
AORI_6760	COG1132	(ABC) transporter
AORI_6764	COG0567	Dehydrogenase, E1 component
AORI_6764	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_6766	COG1404	Belongs to the peptidase S8 family
AORI_6767	COG3153	acetyltransferase
AORI_6769	COG1174	glycine betaine transport
AORI_6770	COG1174	glycine betaine transport
AORI_6771	COG0517	IMP dehydrogenase activity
AORI_6771	COG1125	glycine betaine transport
AORI_6773	COG0281	malic enzyme
AORI_6774	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AORI_6778	COG0406	alpha-ribazole phosphatase activity
AORI_6781	COG1597	lipid kinase activity
AORI_6786	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AORI_6788	COG2135	peptidase activity
AORI_6789	COG1162	GTPase activity
AORI_6794	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_6797	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_6798	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_6800	COG0653	protein targeting
AORI_6801	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AORI_6804	COG5000	phosphorelay sensor kinase activity
AORI_6804	COG5002	protein histidine kinase activity
AORI_6805	COG0745	RESPONSE REGULATOR receiver
AORI_6806	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_6807	COG2146	nitrite reductase [NAD(P)H] activity
AORI_6808	COG1414	Transcriptional regulator
AORI_6810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_6811	COG4638	Rieske (2fe-2S)
AORI_6816	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AORI_6819	COG0531	amino acid
AORI_6821	COG3629	intracellular signal transduction
AORI_6821	COG3903	Transcriptional regulator
AORI_6823	COG1482	cell wall glycoprotein biosynthetic process
AORI_6825	COG2835	tetraacyldisaccharide 4'-kinase activity
AORI_6826	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AORI_6831	COG1994	Peptidase M50
AORI_6834	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_6837	COG0601	transmembrane transport
AORI_6839	COG0747	negative chemotaxis
AORI_6840	COG2826	transposase and inactivated derivatives, IS30 family
AORI_6844	COG0180	Tryptophanyl-tRNA synthetase
AORI_6846	COG2205	protein histidine kinase activity
AORI_6849	COG1131	(ABC) transporter
AORI_6852	COG3842	ATPase activity
AORI_6853	COG4149	molybdate abc transporter
AORI_6855	COG2154	pterin-4-alpha-carbinolamine dehydratase
AORI_6857	COG3654	unkown
AORI_6860	COG2234	aminopeptidase activity
AORI_6869	COG0012	GTP binding
AORI_6872	COG0419	ATPase involved in DNA repair
AORI_6873	COG0420	3'-5' exonuclease activity
AORI_6876	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AORI_6878	COG1570	exodeoxyribonuclease VII activity
AORI_6880	COG1722	exodeoxyribonuclease VII activity
AORI_6883	COG0492	ferredoxin-NADP+ reductase activity
AORI_6884	COG0114	fumarate hydratase activity
AORI_6888	COG1793	dna ligase
AORI_6895	COG1733	regulation of RNA biosynthetic process
AORI_6900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AORI_6906	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AORI_6911	COG1331	Highly conserved protein containing a thioredoxin domain
AORI_6913	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AORI_6915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_6917	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AORI_6918	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_6920	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AORI_6933	COG0183	Belongs to the thiolase family
AORI_6934	COG0477	Major facilitator Superfamily
AORI_6935	COG2391	methyltransferase activity
AORI_6944	COG1902	pentaerythritol trinitrate reductase activity
AORI_6945	COG0789	Transcriptional regulator
AORI_6948	COG0640	Transcriptional regulator
AORI_6949	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_6952	COG2124	cytochrome p450
AORI_6953	COG0406	alpha-ribazole phosphatase activity
AORI_6958	COG4585	Histidine kinase
AORI_6959	COG2197	response regulator
AORI_6962	COG0745	RESPONSE REGULATOR receiver
AORI_6981	COG1252	NADH dehydrogenase
AORI_6983	COG1515	deoxyribonuclease V activity
AORI_6986	COG1404	Belongs to the peptidase S8 family
AORI_6987	COG4608	Belongs to the ABC transporter superfamily
AORI_6988	COG0444	Belongs to the ABC transporter superfamily
AORI_6990	COG0601	transmembrane transport
AORI_6991	COG4166	transmembrane transport
AORI_6996	COG0148	phosphopyruvate hydratase activity
AORI_7005	COG1131	(ABC) transporter
AORI_7007	COG1595	DNA-templated transcription, initiation
AORI_7011	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_7013	COG0586	Pfam SNARE associated Golgi protein
AORI_7015	COG4585	Histidine kinase
AORI_7016	COG2197	response regulator
AORI_7017	COG2133	pyrroloquinoline quinone binding
AORI_7024	COG0745	RESPONSE REGULATOR receiver
AORI_7024	COG3706	GGDEF domain
AORI_7025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AORI_7031	COG0193	aminoacyl-tRNA hydrolase activity
AORI_7034	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_7035	COG0488	(ABC) transporter
AORI_7036	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AORI_7037	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AORI_7038	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AORI_7043	COG0084	hydrolase, TatD family'
AORI_7044	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_7060	COG2258	MOSC domain
AORI_7063	COG1012	belongs to the aldehyde dehydrogenase family
AORI_7066	COG1309	transcriptional regulator
AORI_7073	COG2409	Drug exporters of the RND superfamily
AORI_7074	COG2226	methyltransferase
AORI_7076	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AORI_7078	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_7093	COG0315	cyclic pyranopterin monophosphate synthase activity
AORI_7093	COG0521	Mo-molybdopterin cofactor biosynthetic process
AORI_7094	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AORI_7097	COG5002	protein histidine kinase activity
AORI_7098	COG0745	RESPONSE REGULATOR receiver
AORI_7106	COG1349	DNA-binding transcription factor activity
AORI_7108	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AORI_7110	COG2205	protein histidine kinase activity
AORI_7111	COG0745	RESPONSE REGULATOR receiver
AORI_7112	COG2860	membrane
AORI_7113	COG2197	response regulator
AORI_7122	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AORI_7124	COG1396	sequence-specific DNA binding
AORI_7130	COG3903	Transcriptional regulator
AORI_7130	COG3629	intracellular signal transduction
AORI_7137	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_7140	COG4941	Belongs to the sigma-70 factor family
AORI_7141	COG0789	Transcriptional regulator
AORI_7144	COG2264	protein methyltransferase activity
AORI_7145	COG0583	DNA-binding transcription factor activity
AORI_7147	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_7147	COG2755	lipolytic protein G-D-S-L family
AORI_7157	COG1940	carbohydrate kinase activity
AORI_7162	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AORI_7163	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AORI_7164	COG1984	allophanate hydrolase subunit 2
AORI_7165	COG3145	DNA-N1-methyladenine dioxygenase activity
AORI_7168	COG1321	iron dependent repressor
AORI_7170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AORI_7171	COG1024	Enoyl-CoA hydratase
AORI_7172	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_7175	COG1960	acyl-CoA dehydrogenase activity
AORI_7176	COG1301	dicarboxylic acid transport
AORI_7178	COG1169	isochorismate synthase
AORI_7189	COG0277	FAD linked oxidase domain protein
AORI_7196	COG4152	abc transporter atp-binding protein
AORI_7197	COG1668	transmembrane transport
AORI_7198	COG0415	Belongs to the DNA photolyase family
AORI_7202	COG1960	acyl-CoA dehydrogenase activity
AORI_7205	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_7207	COG2017	converts alpha-aldose to the beta-anomer
AORI_7208	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_7210	COG1309	transcriptional regulator
AORI_7216	COG0259	pyridoxamine-phosphate oxidase activity
AORI_7218	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AORI_7219	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AORI_7220	COG1116	anion transmembrane transporter activity
AORI_7221	COG0642	Histidine kinase
AORI_7227	COG0829	nickel cation binding
AORI_7228	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AORI_7230	COG0804	urea catabolic process
AORI_7231	COG0832	Belongs to the urease beta subunit family
AORI_7232	COG0831	urea catabolic process
AORI_7240	COG1131	(ABC) transporter
AORI_7242	COG4585	Histidine kinase
AORI_7243	COG2197	response regulator
AORI_7244	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_7248	COG5650	phosphatidylinositol metabolic process
AORI_7249	COG0577	efflux transmembrane transporter activity
AORI_7249	COG1136	(ABC) transporter
AORI_7250	COG1136	(ABC) transporter
AORI_7250	COG0577	efflux transmembrane transporter activity
AORI_7254	COG0745	RESPONSE REGULATOR receiver
AORI_7255	COG2205	protein histidine kinase activity
AORI_7260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_7269	COG2814	Major facilitator Superfamily
AORI_7271	COG2252	PERMEase
AORI_7276	COG2814	Major facilitator Superfamily
AORI_7278	COG1278	Cold shock
AORI_7282	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AORI_7285	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_7286	COG0384	phenazine biosynthesis protein PhzF
AORI_7287	COG3304	Inner membrane component domain
AORI_7294	COG1846	Transcriptional regulator
AORI_7295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AORI_7298	COG1388	LysM domain
AORI_7300	COG0521	Mo-molybdopterin cofactor biosynthetic process
AORI_7308	COG2018	Roadblock/LC7 domain
AORI_7311	COG2018	Roadblock/LC7 domain
AORI_7315	COG1174	glycine betaine transport
AORI_7316	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AORI_7317	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AORI_7317	COG1116	anion transmembrane transporter activity
AORI_7319	COG3142	Participates in the control of copper homeostasis
AORI_7323	COG1061	Type III restriction enzyme res subunit
AORI_7326	COG3629	intracellular signal transduction
AORI_7326	COG3903	Transcriptional regulator
AORI_7327	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_7334	COG0459	protein refolding
AORI_7337	COG1278	Cold shock
AORI_7343	COG2261	transglycosylase associated protein
AORI_7345	COG0688	phosphatidylethanolamine metabolic process
AORI_7349	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AORI_7352	COG0242	peptide deformylase activity
AORI_7354	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AORI_7355	COG0351	phosphomethylpyrimidine kinase
AORI_7357	COG1733	regulation of RNA biosynthetic process
AORI_7362	COG2022	thiamine diphosphate biosynthetic process
AORI_7365	COG0352	thiamine-phosphate diphosphorylase activity
AORI_7368	COG0477	Major facilitator Superfamily
AORI_7369	COG2188	Transcriptional regulator
AORI_7370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_7371	COG2971	BadF BadG BcrA BcrD
AORI_7379	COG3629	intracellular signal transduction
AORI_7379	COG3903	Transcriptional regulator
AORI_7380	COG5285	phytanoyl-CoA dioxygenase
AORI_7381	COG1917	Cupin 2, conserved barrel domain protein
AORI_7383	COG0456	acetyltransferase
AORI_7384	COG1752	Esterase of the alpha-beta hydrolase superfamily
AORI_7385	COG4399	Belongs to the UPF0754 family
AORI_7390	COG5416	Lipopolysaccharide assembly protein A domain
AORI_7392	COG0400	carboxylic ester hydrolase activity
AORI_7393	COG0346	lactoylglutathione lyase activity
AORI_7395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_7404	COG1832	CoA-binding protein
AORI_7406	COG1620	l-lactate permease
AORI_7409	COG4941	Belongs to the sigma-70 factor family
AORI_7410	COG3795	YCII-related domain
AORI_7412	COG0583	DNA-binding transcription factor activity
AORI_7419	COG0640	Transcriptional regulator
AORI_7426	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AORI_7433	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AORI_7435	COG1329	Transcriptional regulator
AORI_7436	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AORI_7437	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AORI_7441	COG0215	cysteine-tRNA ligase activity
AORI_7446	COG1309	transcriptional regulator
AORI_7452	COG0235	Class ii aldolase
AORI_7455	COG0698	ribose 5-phosphate isomerase
AORI_7456	COG2376	Dihydroxyacetone kinase
AORI_7457	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_7459	COG1349	DNA-binding transcription factor activity
AORI_7460	COG2814	Major facilitator Superfamily
AORI_7461	COG1070	Carbohydrate kinase
AORI_7464	COG4399	Belongs to the UPF0754 family
AORI_7465	COG4399	Belongs to the UPF0754 family
AORI_7468	COG1120	ATPase activity
AORI_7469	COG0803	Belongs to the bacterial solute-binding protein 9 family
AORI_7470	COG1609	Transcriptional regulator
AORI_7472	COG1194	a g-specific adenine glycosylase
AORI_7478	COG1953	Uracil, thiamine, allantoin
AORI_7482	COG3118	belongs to the thioredoxin family
AORI_7483	COG0596	Alpha beta hydrolase
AORI_7487	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AORI_7493	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AORI_7494	COG0443	Heat shock 70 kDa protein
AORI_7495	COG1396	sequence-specific DNA binding
AORI_7496	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AORI_7497	COG0542	response to heat
AORI_7505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AORI_7506	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AORI_7507	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AORI_7512	COG0789	Transcriptional regulator
AORI_7515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AORI_7516	COG0302	gtp cyclohydrolase
AORI_7517	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AORI_7523	COG0037	tRNA processing
AORI_7526	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AORI_7527	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AORI_7529	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AORI_7533	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AORI_7534	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AORI_7538	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_7539	COG0657	acetylesterase activity
AORI_7546	COG1660	Displays ATPase and GTPase activities
AORI_7559	COG0270	DNA (cytosine-5-)-methyltransferase activity
AORI_7563	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AORI_7564	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AORI_7570	COG1754	DNA topoisomerase type I activity
AORI_7570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AORI_7575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AORI_7576	COG1205	dead DEAH box helicase
AORI_7576	COG1111	helicase
AORI_7586	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_7587	COG3876	Protein conserved in bacteria
AORI_7588	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_7589	COG1737	Transcriptional regulator
AORI_7590	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AORI_7591	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AORI_7592	COG2814	Major facilitator Superfamily
AORI_7593	COG0640	Transcriptional regulator
AORI_7599	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_7601	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AORI_7603	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_7611	COG3104	oligopeptide transport
AORI_7612	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AORI_7614	COG0596	Alpha beta hydrolase
AORI_7617	COG0494	nUDIX hydrolase
AORI_7618	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AORI_7625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_7636	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_7637	COG1408	metallophosphoesterase
AORI_7638	COG2226	methyltransferase
AORI_7642	COG0076	glutamate decarboxylase activity
AORI_7643	COG0783	Belongs to the Dps family
AORI_7644	COG1764	response to oxidative stress
AORI_7651	COG1690	Belongs to the RtcB family
AORI_7652	COG0501	Belongs to the peptidase M48B family
AORI_7662	COG2201	protein-glutamate methylesterase activity
AORI_7667	COG0583	DNA-binding transcription factor activity
AORI_7668	COG0697	spore germination
AORI_7669	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_7672	COG4608	Belongs to the ABC transporter superfamily
AORI_7673	COG0444	Belongs to the ABC transporter superfamily
AORI_7676	COG0747	negative chemotaxis
AORI_7677	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AORI_7679	COG0463	Glycosyl transferase, family 2
AORI_7682	COG0463	Glycosyl transferase, family 2
AORI_7683	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AORI_7684	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AORI_7685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AORI_7686	COG0860	N-Acetylmuramoyl-L-alanine amidase
AORI_7692	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AORI_7693	COG2205	protein histidine kinase activity
AORI_7694	COG0745	RESPONSE REGULATOR receiver
AORI_7697	COG4585	Histidine kinase
AORI_7698	COG2197	response regulator
AORI_7704	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_7705	COG5479	isomerase activity
AORI_7705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_7706	COG5479	isomerase activity
AORI_7706	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_7718	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
AORI_7724	COG4702	Belongs to the UPF0303 family
AORI_7725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_7728	COG3973	AAA domain
AORI_7740	COG0596	Alpha beta hydrolase
AORI_7741	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AORI_7742	COG0745	RESPONSE REGULATOR receiver
AORI_7742	COG3706	GGDEF domain
AORI_7744	COG1316	TRANSCRIPTIONal
AORI_7745	COG0704	Plays a role in the regulation of phosphate uptake
AORI_7746	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AORI_7751	COG0745	RESPONSE REGULATOR receiver
AORI_7758	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AORI_7759	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AORI_7760	COG1984	allophanate hydrolase subunit 2
AORI_7764	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AORI_7770	COG1569	PIN domain
AORI_7771	COG3311	Transcriptional regulator
AORI_7775	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AORI_7776	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AORI_7790	COG1132	(ABC) transporter
AORI_7791	COG1132	(ABC) transporter
AORI_7792	COG0047	phosphoribosylformylglycinamidine synthase activity
AORI_7793	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AORI_7799	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AORI_7800	COG2311	Membrane
AORI_7803	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AORI_7806	COG1126	abc transporter atp-binding protein
AORI_7807	COG0765	amino acid transport
AORI_7808	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_7809	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_7811	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AORI_7820	COG5280	Phage tail tape measure protein TP901
AORI_7820	COG3953	SLT domain
AORI_7827	COG0584	glycerophosphoryl diester phosphodiesterase
AORI_7829	COG2814	Major facilitator Superfamily
AORI_7830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_7832	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AORI_7837	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AORI_7838	COG4172	Belongs to the ABC transporter superfamily
AORI_7839	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_7842	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_7852	COG0667	Aldo Keto reductase
AORI_7853	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_7862	COG0586	Pfam SNARE associated Golgi protein
AORI_7863	COG0277	FAD linked oxidase domain protein
AORI_7864	COG0477	Major facilitator Superfamily
AORI_7866	COG3467	pyridoxamine 5'-phosphate
AORI_7868	COG0477	Major facilitator Superfamily
AORI_7869	COG0586	Pfam SNARE associated Golgi protein
AORI_7871	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_7872	COG1072	(Pantothenic acid kinase))
AORI_7873	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AORI_7877	COG1609	Transcriptional regulator
AORI_7878	COG1609	Transcriptional regulator
AORI_7881	COG0243	molybdopterin cofactor binding
AORI_7882	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_7886	COG1136	(ABC) transporter
AORI_7886	COG0577	efflux transmembrane transporter activity
AORI_7888	COG1285	pathogenesis
AORI_7892	COG0542	response to heat
AORI_7899	COG0789	Transcriptional regulator
AORI_7900	COG0484	heat shock protein binding
AORI_7901	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AORI_7902	COG0443	Heat shock 70 kDa protein
AORI_7909	COG2076	Multidrug Resistance protein
AORI_7910	COG0247	lactate metabolic process
AORI_7910	COG2181	nitrate reductase activity
AORI_7913	COG2340	Cysteine-rich secretory protein family
AORI_7914	COG1846	Transcriptional regulator
AORI_7915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_7916	COG0717	Belongs to the dCTP deaminase family
AORI_7918	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AORI_7925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_7927	COG0737	Belongs to the 5'-nucleotidase family
AORI_7927	COG4085	toxin activity
AORI_7927	COG1525	nuclease
AORI_7928	COG2267	carboxylic ester hydrolase activity
AORI_7932	COG3663	DNA glycosylase
AORI_7933	COG2197	response regulator
AORI_7934	COG1960	acyl-CoA dehydrogenase activity
AORI_7939	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AORI_7951	COG1126	abc transporter atp-binding protein
AORI_7952	COG0765	amino acid transport
AORI_7957	COG1305	Transglutaminase-like
AORI_7958	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_7959	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_7961	COG0596	Alpha beta hydrolase
AORI_7962	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_7964	COG0022	dehydrogenase e1 component
AORI_7965	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_7969	COG3030	protein affecting phage T7 exclusion by the F plasmid
AORI_7973	COG1309	transcriptional regulator
AORI_7974	COG2030	dehydratase
AORI_7975	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_7976	COG0183	Belongs to the thiolase family
AORI_7981	COG0584	glycerophosphoryl diester phosphodiesterase
AORI_7982	COG0789	Transcriptional regulator
AORI_7996	COG1131	(ABC) transporter
AORI_7998	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AORI_8005	COG4585	Histidine kinase
AORI_8006	COG2197	response regulator
AORI_8012	COG1131	(ABC) transporter
AORI_8015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AORI_8017	COG1136	(ABC) transporter
AORI_8019	COG2197	response regulator
AORI_8020	COG0402	S-adenosylhomocysteine deaminase activity
AORI_8021	COG4221	oxidoreductase activity
AORI_8022	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_8023	COG2226	methyltransferase
AORI_8024	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AORI_8024	COG4932	domain protein
AORI_8024	COG3266	domain, Protein
AORI_8027	COG2814	Major facilitator Superfamily
AORI_8029	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_8031	COG1695	Transcriptional regulator
AORI_8033	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_8034	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_8035	COG0673	inositol 2-dehydrogenase activity
AORI_8036	COG1940	carbohydrate kinase activity
AORI_8045	COG0360	Binds together with S18 to 16S ribosomal RNA
AORI_8047	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AORI_8048	COG0359	binds to the 23S rRNA
AORI_8055	COG2267	carboxylic ester hydrolase activity
AORI_8063	COG3384	dioxygenase
AORI_8064	COG0738	Major facilitator superfamily
AORI_8065	COG1846	Transcriptional regulator
AORI_8065	COG1940	carbohydrate kinase activity
AORI_8070	COG2197	response regulator
AORI_8073	COG0477	Major facilitator Superfamily
AORI_8074	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AORI_8075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AORI_8082	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_8083	COG0495	leucyl-tRNA aminoacylation
AORI_8097	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_8099	COG4585	Histidine kinase
AORI_8100	COG0617	tRNA 3'-terminal CCA addition
AORI_8108	COG0492	ferredoxin-NADP+ reductase activity
AORI_8108	COG3118	belongs to the thioredoxin family
AORI_8109	COG0860	N-Acetylmuramoyl-L-alanine amidase
AORI_8109	COG3409	Peptidoglycan-binding domain 1 protein
AORI_8112	COG1181	Belongs to the D-alanine--D-alanine ligase family
AORI_8115	COG1192	Involved in chromosome partitioning
AORI_8116	COG0357	Ribosomal RNA small subunit methyltransferase G
AORI_8118	COG0706	membrane insertase activity
AORI_8119	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AORI_P043	COG0494	nUDIX hydrolase