locus-tag	class	description
CU254_00045	COG0287	Prephenate dehydrogenase
CU254_00050	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU254_00050	COG1902	pentaerythritol trinitrate reductase activity
CU254_00070	COG2197	response regulator
CU254_00085	COG1846	Transcriptional regulator
CU254_00125	COG2318	DinB family
CU254_00135	COG3033	Beta-eliminating lyase
CU254_00215	COG4941	Belongs to the sigma-70 factor family
CU254_00220	COG1846	Transcriptional regulator
CU254_00235	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_00270	COG2130	NADP-dependent
CU254_00275	COG0583	DNA-binding transcription factor activity
CU254_00325	COG2272	Belongs to the type-B carboxylesterase lipase family
CU254_00415	COG0596	Alpha beta hydrolase
CU254_00550	COG0028	Belongs to the TPP enzyme family
CU254_00565	COG2217	Heavy metal translocating P-type atpase
CU254_00570	COG3199	ATP-NAD kinase
CU254_00580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_00585	COG0515	serine threonine protein kinase
CU254_00605	COG1595	DNA-templated transcription, initiation
CU254_00620	COG1278	Cold shock
CU254_00660	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CU254_00665	COG5001	Diguanylate cyclase
CU254_00665	COG3300	MHYT domain
CU254_00685	COG2233	PERMEase
CU254_00690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_00700	COG0789	Transcriptional regulator
CU254_00725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CU254_00755	COG2814	Major facilitator Superfamily
CU254_00760	COG1309	transcriptional regulator
CU254_00775	COG0154	amidase activity
CU254_00810	COG2318	DinB family
CU254_00815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CU254_00835	COG0542	response to heat
CU254_00840	COG2364	Membrane
CU254_00845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_00860	COG2733	membrane
CU254_00885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CU254_00910	COG2986	histidine ammonia-lyase
CU254_00920	COG1174	glycine betaine transport
CU254_00935	COG2130	NADP-dependent
CU254_00965	COG1064	alcohol dehydrogenase
CU254_00995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CU254_01010	COG0438	transferase activity, transferring glycosyl groups
CU254_01040	COG0667	Aldo Keto reductase
CU254_01045	COG5002	protein histidine kinase activity
CU254_01075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU254_01110	COG0560	Phosphoserine phosphatase
CU254_01120	COG1595	DNA-templated transcription, initiation
CU254_01125	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_01145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CU254_01150	COG0181	hydroxymethylbilane synthase activity
CU254_01155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU254_01155	COG1587	Uroporphyrinogen-III synthase
CU254_01180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU254_01185	COG1136	(ABC) transporter
CU254_01190	COG1136	(ABC) transporter
CU254_01190	COG0577	efflux transmembrane transporter activity
CU254_01205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CU254_01210	COG0406	alpha-ribazole phosphatase activity
CU254_01220	COG0785	Cytochrome C biogenesis protein
CU254_01230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU254_01250	COG1522	sequence-specific DNA binding
CU254_01260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU254_01275	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_01280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CU254_01315	COG0438	transferase activity, transferring glycosyl groups
CU254_01330	COG2226	methyltransferase
CU254_01345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU254_01350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU254_01355	COG0649	NAD binding
CU254_01370	COG1034	ATP synthesis coupled electron transport
CU254_01375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CU254_01380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU254_01385	COG0839	Belongs to the complex I subunit 6 family
CU254_01390	COG0713	ATP synthesis coupled electron transport
CU254_01395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CU254_01405	COG1007	ATP synthesis coupled electron transport
CU254_01435	COG1013	pyruvate-flavodoxin oxidoreductase activity
CU254_01440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CU254_01440	COG0674	pyruvate-flavodoxin oxidoreductase activity
CU254_01450	COG1522	sequence-specific DNA binding
CU254_01455	COG1834	amidinotransferase
CU254_01495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU254_01540	COG0463	Glycosyl transferase, family 2
CU254_01540	COG1216	Glycosyl transferase, family 2
CU254_01560	COG0297	glycogen (starch) synthase activity
CU254_01585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CU254_01615	COG0789	Transcriptional regulator
CU254_01635	COG1666	GTP binding
CU254_01650	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CU254_01655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CU254_01690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CU254_01695	COG2030	dehydratase
CU254_01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_01730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CU254_01735	COG0081	regulation of translation
CU254_01750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CU254_01755	COG0222	ribosome binding
CU254_01770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_01795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU254_01825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CU254_01890	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_01920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CU254_01925	COG0049	tRNA binding
CU254_01930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CU254_01940	COG0051	transcription antitermination factor activity, RNA binding
CU254_01945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CU254_01950	COG0088	Forms part of the polypeptide exit tunnel
CU254_01955	COG0089	rRNA binding
CU254_01960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CU254_01965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CU254_01970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CU254_01975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CU254_01980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CU254_01985	COG0255	Belongs to the universal ribosomal protein uL29 family
CU254_01990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CU254_01995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CU254_02000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CU254_02005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CU254_02015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CU254_02020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CU254_02025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CU254_02030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CU254_02035	COG1841	ribosomal large subunit assembly
CU254_02040	COG0200	Binds to the 23S rRNA
CU254_02055	COG0563	adenylate kinase activity
CU254_02070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CU254_02075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CU254_02085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CU254_02090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CU254_02095	COG0202	RNA polymerase activity
CU254_02100	COG0203	ribosomal protein L17
CU254_02105	COG0101	tRNA pseudouridine synthase activity
CU254_02150	COG1404	Belongs to the peptidase S8 family
CU254_02160	COG1674	ftsk spoiiie
CU254_02165	COG0443	Heat shock 70 kDa protein
CU254_02195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CU254_02200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CU254_02205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU254_02240	COG1349	DNA-binding transcription factor activity
CU254_02245	COG1070	Carbohydrate kinase
CU254_02250	COG3842	ATPase activity
CU254_02255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CU254_02265	COG0802	atpase or kinase
CU254_02275	COG2321	neutral zinc metallopeptidase
CU254_02280	COG0477	Major facilitator Superfamily
CU254_02285	COG0825	malonyl-CoA metabolic process
CU254_02285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CU254_02290	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_02325	COG0456	acetyltransferase
CU254_02330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CU254_02365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CU254_02370	COG0459	protein refolding
CU254_02375	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_02380	COG1309	transcriptional regulator
CU254_02435	COG0516	GMP reductase activity
CU254_02450	COG0277	FAD linked oxidase domain protein
CU254_02460	COG1012	belongs to the aldehyde dehydrogenase family
CU254_02475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CU254_02475	COG0519	Catalyzes the synthesis of GMP from XMP
CU254_02515	COG0697	spore germination
CU254_02520	COG0583	DNA-binding transcription factor activity
CU254_02525	COG0515	serine threonine protein kinase
CU254_02530	COG2815	serine threonine protein kinase
CU254_02530	COG0515	serine threonine protein kinase
CU254_02585	COG0045	succinate-CoA ligase (ADP-forming) activity
CU254_02610	COG0138	bifunctional purine biosynthesis protein purh
CU254_02625	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_02640	COG0587	DNA-directed DNA polymerase activity
CU254_02660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CU254_02670	COG2814	Major facilitator Superfamily
CU254_02675	COG0640	Transcriptional regulator
CU254_02680	COG2814	Major facilitator Superfamily
CU254_02710	COG2226	methyltransferase
CU254_02735	COG1234	tRNA 3'-trailer cleavage
CU254_02755	COG0180	Tryptophanyl-tRNA synthetase
CU254_02770	COG1295	ribonuclease BN
CU254_02795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CU254_02810	COG2009	succinate dehydrogenase
CU254_02850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CU254_02855	COG2271	Major facilitator Superfamily
CU254_02860	COG1309	transcriptional regulator
CU254_02895	COG1063	alcohol dehydrogenase
CU254_02910	COG0395	ABC-type sugar transport system, permease component
CU254_02915	COG3842	ATPase activity
CU254_02970	COG1012	belongs to the aldehyde dehydrogenase family
CU254_02975	COG1012	belongs to the aldehyde dehydrogenase family
CU254_02980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CU254_02995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CU254_03005	COG0789	Transcriptional regulator
CU254_03010	COG0667	Aldo Keto reductase
CU254_03030	COG0475	glutathione-regulated potassium exporter activity
CU254_03035	COG0745	RESPONSE REGULATOR receiver
CU254_03050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CU254_03085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU254_03140	COG1473	amidohydrolase
CU254_03140	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_03175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CU254_03180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CU254_03185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CU254_03195	COG4585	Histidine kinase
CU254_03210	COG4770	biotin carboxylase activity
CU254_03255	COG1309	transcriptional regulator
CU254_03270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_03305	COG3511	phospholipase C
CU254_03315	COG3629	intracellular signal transduction
CU254_03315	COG3903	Transcriptional regulator
CU254_03325	COG3103	Sh3 type 3 domain protein
CU254_03325	COG1388	LysM domain
CU254_03325	COG0791	NLP P60 protein
CU254_03360	COG0483	inositol monophosphate 1-phosphatase activity
CU254_03370	COG2205	protein histidine kinase activity
CU254_03415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CU254_03420	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_03450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CU254_03475	COG1316	TRANSCRIPTIONal
CU254_03480	COG1316	TRANSCRIPTIONal
CU254_03565	COG1725	Transcriptional regulator
CU254_03580	COG0778	Nitroreductase
CU254_03580	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CU254_03600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CU254_03615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_03635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_03655	COG1611	Belongs to the LOG family
CU254_03670	COG0463	Glycosyl transferase, family 2
CU254_03680	COG1716	ATPase activity
CU254_03680	COG0842	Transport permease protein
CU254_03680	COG1131	(ABC) transporter
CU254_03685	COG4988	ABC transporter
CU254_03690	COG1294	oxidase, subunit
CU254_03695	COG1271	oxidase subunit
CU254_03720	COG2818	Glycosylase
CU254_03725	COG1024	Enoyl-CoA hydratase
CU254_03735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CU254_03745	COG0583	DNA-binding transcription factor activity
CU254_03750	COG2814	Major facilitator Superfamily
CU254_03755	COG4122	O-methyltransferase activity
CU254_03775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU254_03780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU254_03800	COG2239	Acts as a magnesium transporter
CU254_03810	COG0330	HflC and HflK could
CU254_03825	COG1960	acyl-CoA dehydrogenase activity
CU254_03870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CU254_03885	COG0598	Magnesium transport protein CorA
CU254_03915	COG0613	PHP domain protein
CU254_03920	COG2095	MarC family integral membrane protein
CU254_03940	COG0513	Belongs to the DEAD box helicase family
CU254_03970	COG2267	carboxylic ester hydrolase activity
CU254_04015	COG0243	molybdopterin cofactor binding
CU254_04020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU254_04025	COG2223	nitrite transmembrane transporter activity
CU254_04030	COG2146	nitrite reductase [NAD(P)H] activity
CU254_04030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU254_04035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU254_04035	COG2146	nitrite reductase [NAD(P)H] activity
CU254_04065	COG2378	regulation of single-species biofilm formation
CU254_04080	COG2801	Transposase and inactivated derivatives
CU254_04135	COG0714	Associated with various cellular activities
CU254_04140	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CU254_04170	COG0612	Peptidase, M16
CU254_04190	COG1175	transmembrane transport
CU254_04195	COG0395	ABC-type sugar transport system, permease component
CU254_04200	COG1486	melibiose metabolic process
CU254_04215	COG0640	Transcriptional regulator
CU254_04225	COG3265	gluconokinase activity
CU254_04255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CU254_04265	COG0406	alpha-ribazole phosphatase activity
CU254_04265	COG0328	RNA-DNA hybrid ribonuclease activity
CU254_04275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU254_04340	COG0557	exoribonuclease II activity
CU254_04345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU254_04350	COG1012	belongs to the aldehyde dehydrogenase family
CU254_04375	COG1012	belongs to the aldehyde dehydrogenase family
CU254_04380	COG3842	ATPase activity
CU254_04385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CU254_04390	COG1176	ABC-type spermidine putrescine transport system, permease component I
CU254_04395	COG1177	transmembrane transport
CU254_04400	COG0596	Alpha beta hydrolase
CU254_04410	COG1968	undecaprenyl-diphosphatase activity
CU254_04420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CU254_04435	COG2318	DinB family
CU254_04445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CU254_04445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_04450	COG0653	protein targeting
CU254_04470	COG0174	glutamine synthetase
CU254_04475	COG0154	amidase activity
CU254_04495	COG1522	sequence-specific DNA binding
CU254_04505	COG0505	Belongs to the CarA family
CU254_04515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CU254_04530	COG2080	2 iron, 2 sulfur cluster binding
CU254_04535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CU254_04540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_04590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CU254_04650	COG0300	oxidoreductase activity
CU254_04690	COG1396	sequence-specific DNA binding
CU254_04695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_04700	COG1309	transcriptional regulator
CU254_04710	COG3012	SEC-C Motif Domain Protein
CU254_04720	COG0640	Transcriptional regulator
CU254_04725	COG0798	PFAM Bile acid sodium symporter
CU254_04810	COG3480	Lon protease (S16) C-terminal proteolytic domain
CU254_04820	COG1615	UPF0182 protein
CU254_04840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CU254_04845	COG2884	Cell division ATP-binding protein ftsE
CU254_04850	COG2177	Part of the ABC transporter FtsEX involved in
CU254_04855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CU254_04875	COG2197	response regulator
CU254_04880	COG4585	Histidine kinase
CU254_04900	COG2226	methyltransferase
CU254_04920	COG2986	histidine ammonia-lyase
CU254_04925	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CU254_04935	COG0402	S-adenosylhomocysteine deaminase activity
CU254_04940	COG1228	amidohydrolase
CU254_04970	COG4585	Histidine kinase
CU254_04975	COG2197	response regulator
CU254_04995	COG1131	(ABC) transporter
CU254_05000	COG1643	Atp-dependent helicase
CU254_05005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_05025	COG3883	PFAM NLP P60 protein
CU254_05025	COG0791	NLP P60 protein
CU254_05040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU254_05040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU254_05045	COG0187	DNA topoisomerase II activity
CU254_05085	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_05090	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_05095	COG1129	ABC transporter
CU254_05100	COG1879	ABC-type sugar transport system periplasmic component
CU254_05105	COG1609	Transcriptional regulator
CU254_05140	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_05180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CU254_05195	COG3250	beta-galactosidase activity
CU254_05200	COG0395	ABC-type sugar transport system, permease component
CU254_05205	COG1175	transmembrane transport
CU254_05215	COG1609	Transcriptional regulator
CU254_05245	COG3706	GGDEF domain
CU254_05265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CU254_05280	COG2814	Major facilitator Superfamily
CU254_05300	COG3467	pyridoxamine 5'-phosphate
CU254_05305	COG2353	YceI-like domain
CU254_05315	COG0435	Glutathione S-transferase
CU254_05320	COG0596	Alpha beta hydrolase
CU254_05355	COG1247	-acetyltransferase
CU254_05360	COG1396	sequence-specific DNA binding
CU254_05380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU254_05390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU254_05425	COG4585	Histidine kinase
CU254_05430	COG2197	response regulator
CU254_05470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CU254_05485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU254_05490	COG4585	Histidine kinase
CU254_05575	COG0740	serine-type endopeptidase activity
CU254_05580	COG0740	serine-type endopeptidase activity
CU254_05585	COG1396	sequence-specific DNA binding
CU254_05595	COG0076	glutamate decarboxylase activity
CU254_05600	COG2814	Major facilitator Superfamily
CU254_05605	COG0656	L-ascorbic acid biosynthetic process
CU254_05625	COG2837	iron assimilation
CU254_05665	COG2746	aminoglycoside 3-N-acetyltransferase activity
CU254_05675	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CU254_05680	COG1846	Transcriptional regulator
CU254_05710	COG0745	RESPONSE REGULATOR receiver
CU254_05715	COG2205	protein histidine kinase activity
CU254_05720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_05725	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CU254_05730	COG1181	Belongs to the D-alanine--D-alanine ligase family
CU254_05750	COG3903	Transcriptional regulator
CU254_05750	COG3629	intracellular signal transduction
CU254_05760	COG2197	response regulator
CU254_05765	COG4585	Histidine kinase
CU254_05795	COG0702	epimerase
CU254_05820	COG2124	cytochrome p450
CU254_05840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CU254_05855	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_05870	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_05870	COG3321	synthase
CU254_05870	COG0604	alcohol dehydrogenase
CU254_05875	COG2986	histidine ammonia-lyase
CU254_05885	COG0028	Belongs to the TPP enzyme family
CU254_05885	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CU254_05960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CU254_05965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU254_06000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_06005	COG0765	amino acid transport
CU254_06010	COG1126	abc transporter atp-binding protein
CU254_06025	COG1131	(ABC) transporter
CU254_06030	COG0842	Transport permease protein
CU254_06060	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_06095	COG1879	ABC-type sugar transport system periplasmic component
CU254_06110	COG3629	intracellular signal transduction
CU254_06110	COG3903	Transcriptional regulator
CU254_06120	COG2211	Major facilitator Superfamily
CU254_06130	COG4221	oxidoreductase activity
CU254_06135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CU254_06150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU254_06160	COG1278	Cold shock
CU254_06165	COG0513	Belongs to the DEAD box helicase family
CU254_06185	COG2183	response to ionizing radiation
CU254_06195	COG2072	flavoprotein involved in K transport
CU254_06215	COG2814	Major facilitator Superfamily
CU254_06230	COG0477	Major facilitator Superfamily
CU254_06235	COG1473	amidohydrolase
CU254_06245	COG4977	sequence-specific DNA binding
CU254_06275	COG2030	dehydratase
CU254_06275	COG1012	belongs to the aldehyde dehydrogenase family
CU254_06280	COG3396	Phenylacetate-CoA oxygenase
CU254_06285	COG3460	Phenylacetate-CoA oxygenase
CU254_06290	COG3396	Phenylacetate-CoA oxygenase
CU254_06295	COG2151	metal-sulfur cluster biosynthetic enzyme
CU254_06300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU254_06315	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU254_06350	COG0183	Belongs to the thiolase family
CU254_06375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_06380	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CU254_06385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_06395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_06405	COG3279	Response regulator of the LytR AlgR family
CU254_06410	COG3275	phosphorelay sensor kinase activity
CU254_06415	COG1879	ABC-type sugar transport system periplasmic component
CU254_06420	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_06435	COG1609	Transcriptional regulator
CU254_06440	COG3537	Alpha-1,2-mannosidase
CU254_06445	COG3537	Alpha-1,2-mannosidase
CU254_06455	COG1846	Transcriptional regulator
CU254_06480	COG0058	SHG alpha-glucan phosphorylase activity
CU254_06500	COG1119	ATPase activity
CU254_06505	COG1024	Enoyl-CoA hydratase
CU254_06510	COG2226	methyltransferase
CU254_06525	COG3979	chitinase
CU254_06530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CU254_06545	COG3634	alkyl hydroperoxide reductase activity
CU254_06565	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_06580	COG1309	transcriptional regulator
CU254_06585	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_06620	COG0791	NLP P60 protein
CU254_06620	COG3883	PFAM NLP P60 protein
CU254_06630	COG0110	maltose O-acetyltransferase activity
CU254_06660	COG2076	Multidrug Resistance protein
CU254_06670	COG0596	Alpha beta hydrolase
CU254_06690	COG0386	Belongs to the glutathione peroxidase family
CU254_06700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU254_06710	COG1307	EDD domain protein, DegV family
CU254_06720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CU254_06750	COG0482	sulfurtransferase activity
CU254_06765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_06785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CU254_06805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CU254_06810	COG0154	amidase activity
CU254_06815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CU254_06840	COG0129	dihydroxy-acid dehydratase activity
CU254_06855	COG0440	acetolactate synthase activity
CU254_06860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CU254_06925	COG1404	Belongs to the peptidase S8 family
CU254_06930	COG0473	3-isopropylmalate dehydrogenase activity
CU254_06935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_06940	COG1120	ATPase activity
CU254_06950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_06955	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_07000	COG4176	ABC-type proline glycine betaine transport system permease component
CU254_07005	COG3448	diguanylate cyclase activity
CU254_07005	COG4175	Glycine betaine
CU254_07020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CU254_07025	COG0066	3-isopropylmalate dehydratase activity
CU254_07030	COG0776	regulation of translation
CU254_07055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CU254_07065	COG0252	asparaginase activity
CU254_07080	COG0745	RESPONSE REGULATOR receiver
CU254_07085	COG2205	protein histidine kinase activity
CU254_07095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_07110	COG0477	Major facilitator Superfamily
CU254_07135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CU254_07140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CU254_07150	COG2801	Transposase and inactivated derivatives
CU254_07155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CU254_07160	COG1461	Dihydroxyacetone kinase
CU254_07170	COG3209	COG3209 Rhs family protein
CU254_07195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU254_07255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU254_07280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_07295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_07300	COG3973	AAA domain
CU254_07305	COG0742	ribosomal rna small subunit methyltransferase
CU254_07310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CU254_07335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CU254_07340	COG0571	ribonuclease III activity
CU254_07345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU254_07370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CU254_07375	COG1012	belongs to the aldehyde dehydrogenase family
CU254_07385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CU254_07385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CU254_07390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CU254_07395	COG0509	glycine decarboxylation via glycine cleavage system
CU254_07400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CU254_07405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CU254_07410	COG1760	l-serine dehydratase
CU254_07420	COG2186	Transcriptional regulator
CU254_07425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_07430	COG1120	ATPase activity
CU254_07435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_07440	COG4221	oxidoreductase activity
CU254_07450	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU254_07455	COG2814	Major facilitator Superfamily
CU254_07460	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_07465	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_07480	COG1129	ABC transporter
CU254_07495	COG2186	Transcriptional regulator
CU254_07530	COG1929	Belongs to the glycerate kinase type-1 family
CU254_07540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CU254_07545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CU254_07555	COG3485	protocatechuate 3,4-dioxygenase
CU254_07560	COG3485	protocatechuate 3,4-dioxygenase
CU254_07565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_07570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_07575	COG1414	Transcriptional regulator
CU254_07580	COG0746	molybdenum cofactor guanylyltransferase activity
CU254_07620	COG3706	GGDEF domain
CU254_07655	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_07660	COG1879	ABC-type sugar transport system periplasmic component
CU254_07665	COG1082	Xylose isomerase domain protein TIM barrel
CU254_07675	COG0673	inositol 2-dehydrogenase activity
CU254_07685	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_07695	COG0367	asparagine synthase
CU254_07705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CU254_07710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CU254_07715	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CU254_07735	COG1254	Belongs to the acylphosphatase family
CU254_07755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_07760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CU254_07775	COG1414	Transcriptional regulator
CU254_07795	COG0326	Molecular chaperone. Has ATPase activity
CU254_07815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU254_07820	COG1309	transcriptional regulator
CU254_07825	COG2233	PERMEase
CU254_07850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_07855	COG4266	Belongs to the allantoicase family
CU254_07880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_07890	COG1832	CoA-binding protein
CU254_07920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CU254_07940	COG1132	(ABC) transporter
CU254_07965	COG0228	four-way junction DNA binding
CU254_07975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CU254_07985	COG0336	Belongs to the RNA methyltransferase TrmD family
CU254_07990	COG0335	large ribosomal subunit rRNA binding
CU254_07995	COG0681	Belongs to the peptidase S26 family
CU254_08000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CU254_08010	COG0792	nuclease activity
CU254_08015	COG0606	chelatase, subunit chli
CU254_08035	COG1191	sigma factor activity
CU254_08045	COG0052	Belongs to the universal ribosomal protein uS2 family
CU254_08050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CU254_08055	COG0528	UMP kinase activity
CU254_08060	COG0233	cytoplasmic translational termination
CU254_08075	COG2226	methyltransferase
CU254_08080	COG1695	Transcriptional regulator
CU254_08090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CU254_08095	COG2197	response regulator
CU254_08120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU254_08130	COG2070	2-Nitropropane dioxygenase
CU254_08150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CU254_08195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CU254_08225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_08235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU254_08255	COG1846	Transcriptional regulator
CU254_08265	COG0277	FAD linked oxidase domain protein
CU254_08280	COG0477	Major facilitator Superfamily
CU254_08285	COG0431	NADPH-dependent FMN reductase
CU254_08295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU254_08305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CU254_08315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CU254_08355	COG4977	sequence-specific DNA binding
CU254_08365	COG3345	alpha-galactosidase
CU254_08370	COG0456	acetyltransferase
CU254_08370	COG0454	-acetyltransferase
CU254_08380	COG2186	Transcriptional regulator
CU254_08385	COG2807	transmembrane transport
CU254_08420	COG0513	Belongs to the DEAD box helicase family
CU254_08430	COG0667	Aldo Keto reductase
CU254_08440	COG3022	response to hydroperoxide
CU254_08455	COG0442	prolyl-tRNA aminoacylation
CU254_08465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CU254_08480	COG2197	response regulator
CU254_08500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU254_08510	COG0346	lactoylglutathione lyase activity
CU254_08560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU254_08575	COG4152	abc transporter atp-binding protein
CU254_08580	COG1668	transmembrane transport
CU254_08590	COG3201	nicotinamide mononucleotide transporter
CU254_08605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CU254_08625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_08635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CU254_08650	COG1113	amino acid transport
CU254_08660	COG0587	DNA-directed DNA polymerase activity
CU254_08665	COG0477	Major facilitator Superfamily
CU254_08700	COG4667	esterase of the alpha-beta hydrolase superfamily
CU254_08705	COG0586	Pfam SNARE associated Golgi protein
CU254_08710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CU254_08735	COG0321	lipoyl(octanoyl) transferase activity
CU254_08745	COG1090	epimerase
CU254_08760	COG2826	transposase and inactivated derivatives, IS30 family
CU254_08770	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU254_08775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU254_08815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU254_08825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CU254_08830	COG0667	Aldo Keto reductase
CU254_08860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CU254_08880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CU254_08895	COG1845	cytochrome c oxidase, subunit III
CU254_08900	COG2010	Cytochrome c
CU254_08910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CU254_08950	COG0438	transferase activity, transferring glycosyl groups
CU254_08965	COG2124	cytochrome p450
CU254_08970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_08975	COG0659	secondary active sulfate transmembrane transporter activity
CU254_08980	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CU254_08990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CU254_09000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CU254_09005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CU254_09015	COG1404	Belongs to the peptidase S8 family
CU254_09085	COG1674	ftsk spoiiie
CU254_09110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CU254_09125	COG0477	Major facilitator Superfamily
CU254_09130	COG4977	sequence-specific DNA binding
CU254_09160	COG2197	response regulator
CU254_09165	COG2197	response regulator
CU254_09175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU254_09180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_09185	COG0131	Imidazoleglycerol-phosphate dehydratase
CU254_09195	COG1234	tRNA 3'-trailer cleavage
CU254_09205	COG2409	Drug exporters of the RND superfamily
CU254_09210	COG1309	transcriptional regulator
CU254_09215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU254_09225	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CU254_09235	COG3959	Transketolase, thiamine diphosphate binding domain
CU254_09240	COG3958	Transketolase
CU254_09250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CU254_09255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CU254_09300	COG0107	imidazoleglycerol-phosphate synthase activity
CU254_09320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CU254_09330	COG0134	indole-3-glycerol-phosphate synthase activity
CU254_09335	COG0133	tryptophan synthase activity
CU254_09340	COG0159	tryptophan synthase activity
CU254_09370	COG1473	amidohydrolase
CU254_09375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CU254_09395	COG0069	glutamate synthase activity
CU254_09395	COG0067	glutamate synthase
CU254_09395	COG0070	glutamate synthase
CU254_09410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CU254_09425	COG2268	Band 7 protein
CU254_09435	COG2815	serine threonine protein kinase
CU254_09435	COG0515	serine threonine protein kinase
CU254_09530	COG0242	peptide deformylase activity
CU254_09535	COG1201	RNA secondary structure unwinding
CU254_09545	COG0443	Heat shock 70 kDa protein
CU254_09555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CU254_09560	COG2137	regulation of response to DNA damage stimulus
CU254_09565	COG0800	Aldolase
CU254_09590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU254_09665	COG0765	amino acid transport
CU254_09670	COG0765	amino acid transport
CU254_09675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_09680	COG1126	abc transporter atp-binding protein
CU254_09690	COG0642	Histidine kinase
CU254_09705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU254_09715	COG1196	nuclear chromosome segregation
CU254_09720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CU254_09730	COG0525	valine-tRNA ligase activity
CU254_09745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU254_09755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CU254_09765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CU254_09775	COG1309	transcriptional regulator
CU254_09815	COG1505	serine-type exopeptidase activity
CU254_09845	COG2936	dipeptidyl-peptidase activity
CU254_09850	COG2197	response regulator
CU254_09855	COG4585	Histidine kinase
CU254_09870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU254_09875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CU254_09895	COG0123	including yeast histone deacetylase and acetoin utilization protein
CU254_09905	COG1960	acyl-CoA dehydrogenase activity
CU254_09910	COG1960	acyl-CoA dehydrogenase activity
CU254_09930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_09935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_10005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_10040	COG0003	Pfam Anion-transporting ATPase
CU254_10050	COG1940	carbohydrate kinase activity
CU254_10060	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_10065	COG1309	transcriptional regulator
CU254_10075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_10105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CU254_10145	COG0640	Transcriptional regulator
CU254_10165	COG1946	Acyl-CoA thioesterase
CU254_10185	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU254_10185	COG1672	PFAM Archaeal ATPase
CU254_10195	COG3226	Transcriptional regulator
CU254_10200	COG1960	acyl-CoA dehydrogenase activity
CU254_10205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_10225	COG1566	PFAM secretion protein HlyD family protein
CU254_10235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_10250	COG2018	Roadblock/LC7 domain
CU254_10285	COG1703	isobutyryl-CoA mutase activity
CU254_10285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CU254_10285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CU254_10295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_10300	COG1960	acyl-CoA dehydrogenase activity
CU254_10305	COG1309	transcriptional regulator
CU254_10330	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_10350	COG0302	gtp cyclohydrolase
CU254_10360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_10385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_10390	COG1960	acyl-CoA dehydrogenase activity
CU254_10395	COG1960	acyl-CoA dehydrogenase activity
CU254_10400	COG2030	dehydratase
CU254_10425	COG0196	riboflavin kinase activity
CU254_10460	COG1960	acyl-CoA dehydrogenase activity
CU254_10465	COG2267	carboxylic ester hydrolase activity
CU254_10470	COG0346	lactoylglutathione lyase activity
CU254_10475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_10490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_10510	COG2084	Dehydrogenase
CU254_10520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_10535	COG0596	Alpha beta hydrolase
CU254_10550	COG0183	Belongs to the thiolase family
CU254_10555	COG2124	cytochrome p450
CU254_10565	COG1295	ribonuclease BN
CU254_10575	COG0183	Belongs to the thiolase family
CU254_10590	COG1024	Enoyl-CoA hydratase
CU254_10600	COG2070	2-Nitropropane dioxygenase
CU254_10625	COG2188	Transcriptional regulator
CU254_10635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_10640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_10680	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CU254_10680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CU254_10690	COG1490	D-aminoacyl-tRNA deacylase activity
CU254_10695	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_10700	COG1473	amidohydrolase
CU254_10715	COG2313	pseudouridylate synthase activity
CU254_10745	COG4213	ABC transporter substrate-binding protein
CU254_10755	COG4214	carbohydrate transport
CU254_10775	COG0174	glutamine synthetase
CU254_10785	COG1733	regulation of RNA biosynthetic process
CU254_10790	COG2910	NAD(P)H-binding
CU254_10795	COG0531	amino acid
CU254_10805	COG4585	Histidine kinase
CU254_10860	COG1940	carbohydrate kinase activity
CU254_10865	COG0483	inositol monophosphate 1-phosphatase activity
CU254_10885	COG0756	dUTP diphosphatase activity
CU254_10915	COG0569	domain protein
CU254_10920	COG0531	amino acid
CU254_10925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CU254_10950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CU254_10975	COG1012	belongs to the aldehyde dehydrogenase family
CU254_11005	COG0745	RESPONSE REGULATOR receiver
CU254_11010	COG2205	protein histidine kinase activity
CU254_11030	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_11030	COG1024	Enoyl-CoA hydratase
CU254_11035	COG0183	Belongs to the thiolase family
CU254_11045	COG1024	Enoyl-CoA hydratase
CU254_11045	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_11055	COG1414	Transcriptional regulator
CU254_11065	COG2197	response regulator
CU254_11075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CU254_11090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_11105	COG3220	belongs to the UPF0276 family
CU254_11125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU254_11135	COG0515	serine threonine protein kinase
CU254_11135	COG2815	serine threonine protein kinase
CU254_11155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_11165	COG2508	Transcriptional regulator
CU254_11165	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CU254_11170	COG1012	belongs to the aldehyde dehydrogenase family
CU254_11175	COG0506	proline dehydrogenase activity
CU254_11180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU254_11200	COG1793	dna ligase
CU254_11250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU254_11255	COG2326	polyphosphate kinase activity
CU254_11275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CU254_11330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CU254_11345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CU254_11350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU254_11370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU254_11375	COG2190	(PTS) system
CU254_11375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU254_11375	COG1263	PTS System
CU254_11385	COG1263	PTS System
CU254_11385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU254_11420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CU254_11425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CU254_11430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CU254_11435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CU254_11455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CU254_11460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CU254_11470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CU254_11475	COG0540	Belongs to the ATCase OTCase family
CU254_11490	COG0505	Belongs to the CarA family
CU254_11500	COG0284	orotidine-5'-phosphate decarboxylase activity
CU254_11510	COG0194	GDP metabolic process
CU254_11515	COG1758	RNA polymerase activity
CU254_11525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CU254_11555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU254_11570	COG1610	YqeY-like protein
CU254_11575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CU254_11605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU254_11605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU254_11610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CU254_11625	COG0322	excinuclease ABC activity
CU254_11630	COG1660	Displays ATPase and GTPase activities
CU254_11635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CU254_11640	COG1481	regulation of sporulation
CU254_11645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_11650	COG2133	pyrroloquinoline quinone binding
CU254_11680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU254_11685	COG0126	phosphoglycerate kinase activity
CU254_11690	COG0149	triose-phosphate isomerase activity
CU254_11705	COG4585	Histidine kinase
CU254_11715	COG0363	glucosamine-6-phosphate deaminase activity
CU254_11730	COG0166	Belongs to the GPI family
CU254_11735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU254_11745	COG0109	protoheme IX farnesyltransferase activity
CU254_11785	COG1612	heme a metabolic process
CU254_11795	COG1131	(ABC) transporter
CU254_11835	COG2151	metal-sulfur cluster biosynthetic enzyme
CU254_11850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CU254_11860	COG2226	methyltransferase
CU254_11865	COG4585	Histidine kinase
CU254_11870	COG2197	response regulator
CU254_11875	COG2200	EAL domain
CU254_11875	COG2199	diguanylate cyclase activity
CU254_11880	COG0644	oxidoreductase
CU254_11905	COG0488	(ABC) transporter
CU254_11920	COG1132	(ABC) transporter
CU254_11935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU254_11940	COG1316	TRANSCRIPTIONal
CU254_11980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_11985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_11995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU254_12000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CU254_12000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU254_12025	COG1960	acyl-CoA dehydrogenase activity
CU254_12030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_12055	COG3469	chitinase activity
CU254_12090	COG1132	(ABC) transporter
CU254_12095	COG1132	(ABC) transporter
CU254_12100	COG1505	serine-type exopeptidase activity
CU254_12110	COG0515	serine threonine protein kinase
CU254_12130	COG0546	phosphoglycolate phosphatase activity
CU254_12180	COG1846	Transcriptional regulator
CU254_12185	COG1012	belongs to the aldehyde dehydrogenase family
CU254_12220	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CU254_12235	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_12250	COG0477	Major facilitator Superfamily
CU254_12310	COG0402	S-adenosylhomocysteine deaminase activity
CU254_12330	COG2368	4-hydroxyphenylacetate
CU254_12355	COG1984	allophanate hydrolase subunit 2
CU254_12385	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CU254_12405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CU254_12425	COG1984	allophanate hydrolase subunit 2
CU254_12470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_12500	COG0577	efflux transmembrane transporter activity
CU254_12505	COG4585	Histidine kinase
CU254_12510	COG2197	response regulator
CU254_12545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_12565	COG1063	alcohol dehydrogenase
CU254_12575	COG0154	amidase activity
CU254_12580	COG2223	nitrite transmembrane transporter activity
CU254_12585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_12650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU254_12745	COG3033	Beta-eliminating lyase
CU254_12765	COG2186	Transcriptional regulator
CU254_12770	COG0346	lactoylglutathione lyase activity
CU254_12795	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_12800	COG2186	Transcriptional regulator
CU254_12810	COG0747	negative chemotaxis
CU254_12820	COG0444	Belongs to the ABC transporter superfamily
CU254_12840	COG0028	Belongs to the TPP enzyme family
CU254_12855	COG0022	dehydrogenase e1 component
CU254_12860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU254_12865	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CU254_12905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU254_12915	COG0596	Alpha beta hydrolase
CU254_12945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CU254_12955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_12985	COG1021	2,3-dihydroxybenzoate-AMP ligase
CU254_12990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_12995	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_13000	COG1169	isochorismate synthase
CU254_13005	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CU254_13010	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_13020	COG0477	Major facilitator Superfamily
CU254_13025	COG3469	chitinase activity
CU254_13030	COG0456	acetyltransferase
CU254_13030	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU254_13035	COG1960	acyl-CoA dehydrogenase activity
CU254_13040	COG1960	acyl-CoA dehydrogenase activity
CU254_13045	COG1960	acyl-CoA dehydrogenase activity
CU254_13070	COG0484	heat shock protein binding
CU254_13080	COG0531	amino acid
CU254_13085	COG3250	beta-galactosidase activity
CU254_13105	COG2124	cytochrome p450
CU254_13140	COG1846	Transcriptional regulator
CU254_13150	COG0477	Major facilitator Superfamily
CU254_13160	COG1793	dna ligase
CU254_13230	COG2807	transmembrane transport
CU254_13240	COG1309	transcriptional regulator
CU254_13250	COG2814	Major facilitator Superfamily
CU254_13265	COG0587	DNA-directed DNA polymerase activity
CU254_13275	COG0439	Biotin carboxylase
CU254_13280	COG1129	ABC transporter
CU254_13285	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_13290	COG1879	ABC-type sugar transport system periplasmic component
CU254_13315	COG0656	L-ascorbic acid biosynthetic process
CU254_13320	COG0297	glycogen (starch) synthase activity
CU254_13345	COG0069	glutamate synthase activity
CU254_13370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_13380	COG1131	(ABC) transporter
CU254_13400	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_13410	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_13415	COG0297	glycogen (starch) synthase activity
CU254_13420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU254_13435	COG2188	Transcriptional regulator
CU254_13455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_13460	COG4608	Belongs to the ABC transporter superfamily
CU254_13465	COG0444	Belongs to the ABC transporter superfamily
CU254_13475	COG0747	negative chemotaxis
CU254_13480	COG2186	Transcriptional regulator
CU254_13495	COG0673	inositol 2-dehydrogenase activity
CU254_13515	COG2205	protein histidine kinase activity
CU254_13520	COG0745	RESPONSE REGULATOR receiver
CU254_13530	COG4941	Belongs to the sigma-70 factor family
CU254_13535	COG3795	YCII-related domain
CU254_13665	COG2124	cytochrome p450
CU254_13670	COG1309	transcriptional regulator
CU254_13675	COG2801	Transposase and inactivated derivatives
CU254_13695	COG2423	ornithine cyclodeaminase activity
CU254_13700	COG4106	trans-aconitate 2-methyltransferase activity
CU254_13710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_13725	COG0148	phosphopyruvate hydratase activity
CU254_13740	COG4991	sh3 domain protein
CU254_13755	COG4941	Belongs to the sigma-70 factor family
CU254_13795	COG0488	(ABC) transporter
CU254_13835	COG0583	DNA-binding transcription factor activity
CU254_13840	COG5006	permease, DMT superfamily
CU254_13870	COG1309	transcriptional regulator
CU254_13890	COG0583	DNA-binding transcription factor activity
CU254_13895	COG2814	Major facilitator Superfamily
CU254_13920	COG1657	PFAM Prenyltransferase squalene oxidase
CU254_13930	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CU254_13940	COG1562	ergosterol biosynthetic process
CU254_13950	COG0300	oxidoreductase activity
CU254_13960	COG0697	spore germination
CU254_13975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU254_13980	COG0583	DNA-binding transcription factor activity
CU254_13990	COG1119	ATPase activity
CU254_14020	COG1120	ATPase activity
CU254_14050	COG0277	FAD linked oxidase domain protein
CU254_14055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CU254_14085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_14100	COG1609	Transcriptional regulator
CU254_14125	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_14150	COG3537	Alpha-1,2-mannosidase
CU254_14155	COG2814	Major facilitator Superfamily
CU254_14160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CU254_14230	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CU254_14265	COG3903	Transcriptional regulator
CU254_14265	COG3629	intracellular signal transduction
CU254_14280	COG2814	Major facilitator Superfamily
CU254_14285	COG0387	Pfam Sodium calcium exchanger
CU254_14305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU254_14325	COG2378	regulation of single-species biofilm formation
CU254_14335	COG2267	carboxylic ester hydrolase activity
CU254_14365	COG0535	radical SAM domain protein
CU254_14430	COG1169	isochorismate synthase
CU254_14440	COG2197	response regulator
CU254_14445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_14480	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_14485	COG1024	Enoyl-CoA hydratase
CU254_14495	COG1024	Enoyl-CoA hydratase
CU254_14500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_14510	COG2271	Major facilitator Superfamily
CU254_14520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_14540	COG0477	Major facilitator Superfamily
CU254_14555	COG0438	transferase activity, transferring glycosyl groups
CU254_14565	COG0477	Major facilitator Superfamily
CU254_14570	COG3962	Belongs to the TPP enzyme family
CU254_14575	COG3718	enzyme involved in inositol metabolism
CU254_14590	COG2188	Transcriptional regulator
CU254_14600	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CU254_14610	COG0247	lactate metabolic process
CU254_14610	COG0277	FAD linked oxidase domain protein
CU254_14615	COG2186	Transcriptional regulator
CU254_14750	COG0438	transferase activity, transferring glycosyl groups
CU254_14885	COG5002	protein histidine kinase activity
CU254_14885	COG5001	Diguanylate cyclase
CU254_14885	COG3447	MASE1 domain protein
CU254_14905	COG0596	Alpha beta hydrolase
CU254_14920	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CU254_14940	COG2197	response regulator
CU254_14960	COG1012	belongs to the aldehyde dehydrogenase family
CU254_14975	COG1176	ABC-type spermidine putrescine transport system, permease component I
CU254_14980	COG1177	transmembrane transport
CU254_14985	COG3842	ATPase activity
CU254_14995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_15055	COG2261	transglycosylase associated protein
CU254_15060	COG1595	DNA-templated transcription, initiation
CU254_15065	COG2226	methyltransferase
CU254_15080	COG3511	phospholipase C
CU254_15090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_15105	COG0640	Transcriptional regulator
CU254_15130	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_15140	COG1012	belongs to the aldehyde dehydrogenase family
CU254_15145	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CU254_15175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU254_15185	COG0596	Alpha beta hydrolase
CU254_15205	COG0477	Major facilitator Superfamily
CU254_15250	COG1136	(ABC) transporter
CU254_15270	COG2072	flavoprotein involved in K transport
CU254_15280	COG2186	Transcriptional regulator
CU254_15295	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_15300	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_15305	COG0154	amidase activity
CU254_15315	COG1960	acyl-CoA dehydrogenase activity
CU254_15320	COG1960	acyl-CoA dehydrogenase activity
CU254_15325	COG1960	acyl-CoA dehydrogenase activity
CU254_15330	COG1024	Enoyl-CoA hydratase
CU254_15335	COG1960	acyl-CoA dehydrogenase activity
CU254_15355	COG1454	alcohol dehydrogenase
CU254_15360	COG0531	amino acid
CU254_15405	COG0531	amino acid
CU254_15435	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_15440	COG0277	FAD linked oxidase domain protein
CU254_15440	COG0247	lactate metabolic process
CU254_15445	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_15450	COG0028	Belongs to the TPP enzyme family
CU254_15455	COG3387	PFAM Glycoside hydrolase 15-related
CU254_15465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CU254_15470	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CU254_15480	COG0306	phosphate transporter
CU254_15490	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_15550	COG2259	Doxx family
CU254_15560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CU254_15570	COG0531	amino acid
CU254_15585	COG2318	DinB family
CU254_15635	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_15650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_15655	COG0778	Nitroreductase
CU254_15660	COG1309	transcriptional regulator
CU254_15680	COG2814	Major facilitator Superfamily
CU254_15690	COG1733	regulation of RNA biosynthetic process
CU254_15700	COG0604	alcohol dehydrogenase
CU254_15715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_15720	COG0477	Major facilitator Superfamily
CU254_15745	COG1335	isochorismatase
CU254_15750	COG0596	Alpha beta hydrolase
CU254_15755	COG2309	aminopeptidase activity
CU254_15800	COG0243	molybdopterin cofactor binding
CU254_15815	COG0438	transferase activity, transferring glycosyl groups
CU254_15840	COG2192	nodulation
CU254_15845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CU254_15850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CU254_15850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CU254_15855	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_15865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU254_15890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CU254_15895	COG0859	PFAM glycosyl transferase family 9
CU254_15900	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_15925	COG0640	Transcriptional regulator
CU254_15940	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CU254_15950	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CU254_15975	COG0583	DNA-binding transcription factor activity
CU254_15995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_16030	COG2801	Transposase and inactivated derivatives
CU254_16050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU254_16055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU254_16065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU254_16075	COG0667	Aldo Keto reductase
CU254_16135	COG2197	response regulator
CU254_16145	COG2814	Major facilitator Superfamily
CU254_16165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_16205	COG2239	Acts as a magnesium transporter
CU254_16255	COG1733	regulation of RNA biosynthetic process
CU254_16265	COG1309	transcriptional regulator
CU254_16275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CU254_16290	COG1132	(ABC) transporter
CU254_16295	COG1132	(ABC) transporter
CU254_16305	COG0515	serine threonine protein kinase
CU254_16330	COG1486	melibiose metabolic process
CU254_16335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_16340	COG0395	ABC-type sugar transport system, permease component
CU254_16355	COG0673	inositol 2-dehydrogenase activity
CU254_16360	COG1349	DNA-binding transcription factor activity
CU254_16365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU254_16375	COG0191	fructose-bisphosphate aldolase activity
CU254_16395	COG0402	S-adenosylhomocysteine deaminase activity
CU254_16400	COG1802	Transcriptional regulator
CU254_16405	COG1228	amidohydrolase
CU254_16410	COG1228	amidohydrolase
CU254_16415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_16435	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_16450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_16460	COG0601	transmembrane transport
CU254_16470	COG4608	Belongs to the ABC transporter superfamily
CU254_16490	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CU254_16490	COG3291	Pkd domain containing protein
CU254_16540	COG0693	protein deglycase activity
CU254_16580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CU254_16605	COG0010	Belongs to the arginase family
CU254_16625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CU254_16635	COG0277	FAD linked oxidase domain protein
CU254_16650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CU254_16665	COG0243	molybdopterin cofactor binding
CU254_16700	COG0366	Alpha amylase catalytic
CU254_16710	COG1175	transmembrane transport
CU254_16720	COG1609	Transcriptional regulator
CU254_16745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_16755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_16795	COG0748	coenzyme F420 binding
CU254_16815	COG1846	Transcriptional regulator
CU254_16850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_16855	COG0601	transmembrane transport
CU254_16860	COG0747	negative chemotaxis
CU254_16870	COG1609	Transcriptional regulator
CU254_16935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_16940	COG1414	Transcriptional regulator
CU254_16970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_17025	COG0596	Alpha beta hydrolase
CU254_17030	COG2807	transmembrane transport
CU254_17065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_17075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_17095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_17135	COG0300	oxidoreductase activity
CU254_17140	COG0129	dihydroxy-acid dehydratase activity
CU254_17155	COG0395	ABC-type sugar transport system, permease component
CU254_17170	COG1609	Transcriptional regulator
CU254_17175	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_17210	COG3794	PFAM blue (type 1) copper domain protein
CU254_17275	COG1733	regulation of RNA biosynthetic process
CU254_17300	COG0477	Major facilitator Superfamily
CU254_17315	COG0542	response to heat
CU254_17340	COG0640	Transcriptional regulator
CU254_17355	COG0477	Major facilitator Superfamily
CU254_17375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CU254_17390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_17395	COG2226	methyltransferase
CU254_17405	COG1410	methionine synthase
CU254_17405	COG0646	methionine synthase
CU254_17415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CU254_17470	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_17510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CU254_17570	COG1113	amino acid transport
CU254_17575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_17585	COG1414	Transcriptional regulator
CU254_17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_17620	COG0686	Belongs to the AlaDH PNT family
CU254_17625	COG0280	phosphate acetyltransferase
CU254_17650	COG0583	DNA-binding transcription factor activity
CU254_17675	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
CU254_17715	COG4172	Belongs to the ABC transporter superfamily
CU254_17725	COG0601	transmembrane transport
CU254_17730	COG0747	negative chemotaxis
CU254_17740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU254_17755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU254_17765	COG0681	Belongs to the peptidase S26 family
CU254_17775	COG2327	Polysaccharide pyruvyl transferase
CU254_17780	COG0438	transferase activity, transferring glycosyl groups
CU254_17790	COG0438	transferase activity, transferring glycosyl groups
CU254_17800	COG0438	transferase activity, transferring glycosyl groups
CU254_17810	COG1215	transferase activity, transferring glycosyl groups
CU254_17820	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CU254_17825	COG1376	ErfK ybiS ycfS ynhG family protein
CU254_17840	COG4638	Rieske (2fe-2S)
CU254_17885	COG0656	L-ascorbic acid biosynthetic process
CU254_17900	COG1253	flavin adenine dinucleotide binding
CU254_17930	COG2267	carboxylic ester hydrolase activity
CU254_17935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU254_17940	COG0583	DNA-binding transcription factor activity
CU254_17945	COG3572	ergothioneine biosynthetic process
CU254_17950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CU254_17955	COG0121	glutamine amidotransferase
CU254_17960	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CU254_17980	COG2822	iron ion transport
CU254_17985	COG2837	iron assimilation
CU254_17990	COG3511	phospholipase C
CU254_17995	COG2801	Transposase and inactivated derivatives
CU254_18000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CU254_18005	COG0791	NLP P60 protein
CU254_18005	COG3883	PFAM NLP P60 protein
CU254_18020	COG0714	Associated with various cellular activities
CU254_18030	COG2304	oxidoreductase activity
CU254_18045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CU254_18060	COG2205	protein histidine kinase activity
CU254_18070	COG0477	Major facilitator Superfamily
CU254_18080	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CU254_18110	COG4867	von Willebrand factor, type A
CU254_18115	COG0789	Transcriptional regulator
CU254_18120	COG0215	cysteine-tRNA ligase activity
CU254_18125	COG0488	(ABC) transporter
CU254_18140	COG2814	Major facilitator Superfamily
CU254_18160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_18165	COG0140	phosphoribosyl-ATP diphosphatase activity
CU254_18170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CU254_18175	COG1192	Involved in chromosome partitioning
CU254_18190	COG1994	Peptidase M50
CU254_18190	COG0517	IMP dehydrogenase activity
CU254_18210	COG1222	aaa ATPase
CU254_18250	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CU254_18255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CU254_18260	COG4941	Belongs to the sigma-70 factor family
CU254_18265	COG3795	YCII-related domain
CU254_18280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CU254_18305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU254_18315	COG1597	lipid kinase activity
CU254_18330	COG4552	Acetyltransferase involved in intracellular survival and related
CU254_18340	COG4552	Acetyltransferase involved in intracellular survival and related
CU254_18380	COG1309	transcriptional regulator
CU254_18385	COG4941	Belongs to the sigma-70 factor family
CU254_18395	COG4221	oxidoreductase activity
CU254_18400	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_18420	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_18460	COG2814	Major facilitator Superfamily
CU254_18475	COG0667	Aldo Keto reductase
CU254_18480	COG1063	alcohol dehydrogenase
CU254_18485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CU254_18490	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_18510	COG0601	transmembrane transport
CU254_18515	COG0444	Belongs to the ABC transporter superfamily
CU254_18520	COG4172	Belongs to the ABC transporter superfamily
CU254_18550	COG1960	acyl-CoA dehydrogenase activity
CU254_18580	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU254_18585	COG0038	chloride channel
CU254_18590	COG5000	phosphorelay sensor kinase activity
CU254_18590	COG5002	protein histidine kinase activity
CU254_18595	COG0745	RESPONSE REGULATOR receiver
CU254_18600	COG0235	Class ii aldolase
CU254_18605	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_18625	COG1414	Transcriptional regulator
CU254_18630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_18665	COG2271	Major facilitator Superfamily
CU254_18675	COG1309	transcriptional regulator
CU254_18690	COG0596	Alpha beta hydrolase
CU254_18695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_18700	COG0183	Belongs to the thiolase family
CU254_18705	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CU254_18715	COG1960	acyl-CoA dehydrogenase activity
CU254_18725	COG1960	acyl-CoA dehydrogenase activity
CU254_18735	COG0154	amidase activity
CU254_18740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_18770	COG3511	phospholipase C
CU254_18775	COG3511	phospholipase C
CU254_18800	COG1088	dTDP-glucose 4,6-dehydratase activity
CU254_18805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_18815	COG2205	protein histidine kinase activity
CU254_18825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_18850	COG0477	Major facilitator Superfamily
CU254_18875	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_18910	COG1012	belongs to the aldehyde dehydrogenase family
CU254_18925	COG3268	Saccharopine dehydrogenase
CU254_18955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_18965	COG0463	Glycosyl transferase, family 2
CU254_18975	COG0640	Transcriptional regulator
CU254_18985	COG2814	Major facilitator Superfamily
CU254_18990	COG0583	DNA-binding transcription factor activity
CU254_19005	COG1435	thymidine kinase activity
CU254_19035	COG0789	Transcriptional regulator
CU254_19045	COG4974	Belongs to the 'phage' integrase family
CU254_19050	COG4221	oxidoreductase activity
CU254_19060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_19065	COG1309	transcriptional regulator
CU254_19070	COG1960	acyl-CoA dehydrogenase activity
CU254_19075	COG2226	methyltransferase
CU254_19080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_19090	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_19095	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CU254_19115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU254_19130	COG0596	Alpha beta hydrolase
CU254_19135	COG3795	YCII-related domain
CU254_19195	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU254_19210	COG2318	DinB family
CU254_19225	COG1309	transcriptional regulator
CU254_19230	COG1357	PFAM Pentapeptide repeats (8 copies)
CU254_19355	COG1136	(ABC) transporter
CU254_19370	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_19375	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CU254_19430	COG0477	Major facilitator Superfamily
CU254_19450	COG0667	Aldo Keto reductase
CU254_19470	COG0823	Involved in the tonB-independent uptake of proteins
CU254_19470	COG1506	peptidase
CU254_19470	COG4946	Tricorn protease homolog
CU254_19475	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU254_19510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_19515	COG0601	transmembrane transport
CU254_19520	COG4166	transmembrane transport
CU254_19530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_19550	COG3537	Alpha-1,2-mannosidase
CU254_19570	COG0667	Aldo Keto reductase
CU254_19585	COG1846	Transcriptional regulator
CU254_19595	COG0039	L-malate dehydrogenase activity
CU254_19630	COG3979	chitinase
CU254_19635	COG2271	Major facilitator Superfamily
CU254_19640	COG0339	signal peptide processing
CU254_19650	COG1968	undecaprenyl-diphosphatase activity
CU254_19655	COG0667	Aldo Keto reductase
CU254_19670	COG4941	Belongs to the sigma-70 factor family
CU254_19710	COG1309	transcriptional regulator
CU254_19715	COG3246	L-lysine catabolic process to acetate
CU254_19720	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_19740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_19785	COG3285	dna ligase
CU254_19785	COG1793	dna ligase
CU254_19855	COG4221	oxidoreductase activity
CU254_19875	COG3960	tartronate-semialdehyde synthase activity
CU254_19880	COG2084	Dehydrogenase
CU254_19885	COG3622	Belongs to the hyi family
CU254_19895	COG2850	peptidyl-arginine hydroxylation
CU254_19905	COG1802	Transcriptional regulator
CU254_19915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU254_19925	COG0277	FAD linked oxidase domain protein
CU254_19940	COG0583	DNA-binding transcription factor activity
CU254_19950	COG1053	succinate dehydrogenase
CU254_19955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CU254_19970	COG1012	belongs to the aldehyde dehydrogenase family
CU254_19985	COG0583	DNA-binding transcription factor activity
CU254_19990	COG2072	flavoprotein involved in K transport
CU254_20020	COG0531	amino acid
CU254_20045	COG4172	Belongs to the ABC transporter superfamily
CU254_20050	COG0747	negative chemotaxis
CU254_20075	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_20115	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_20150	COG0009	L-threonylcarbamoyladenylate synthase
CU254_20180	COG0456	acetyltransferase
CU254_20185	COG1063	alcohol dehydrogenase
CU254_20195	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CU254_20195	COG0778	Nitroreductase
CU254_20205	COG0702	epimerase
CU254_20245	COG1716	ATPase activity
CU254_20275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_20280	COG1024	Enoyl-CoA hydratase
CU254_20285	COG2267	carboxylic ester hydrolase activity
CU254_20290	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_20295	COG1309	transcriptional regulator
CU254_20300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_20305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU254_20305	COG1648	precorrin-2 dehydrogenase activity
CU254_20310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CU254_20315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CU254_20320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CU254_20325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CU254_20335	COG0254	rRNA binding
CU254_20345	COG0523	cobalamin synthesis protein
CU254_20370	COG2211	Major facilitator Superfamily
CU254_20375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_20400	COG1414	Transcriptional regulator
CU254_20410	COG1228	amidohydrolase
CU254_20440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_20450	COG1116	anion transmembrane transporter activity
CU254_20455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU254_20465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_20480	COG1132	(ABC) transporter
CU254_20485	COG1132	(ABC) transporter
CU254_20495	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CU254_20505	COG0488	(ABC) transporter
CU254_20515	COG1024	Enoyl-CoA hydratase
CU254_20550	COG1937	Protein conserved in bacteria
CU254_20565	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_20580	COG0405	Gamma-glutamyltransferase
CU254_20655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU254_20660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_20665	COG1414	Transcriptional regulator
CU254_20670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU254_20675	COG0022	dehydrogenase e1 component
CU254_20680	COG4689	acetoacetate decarboxylase
CU254_20685	COG0477	Major facilitator Superfamily
CU254_20710	COG2814	Major facilitator Superfamily
CU254_20735	COG2271	Major facilitator Superfamily
CU254_20785	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_20830	COG2271	Major facilitator Superfamily
CU254_20850	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CU254_20860	COG0577	efflux transmembrane transporter activity
CU254_20860	COG1136	(ABC) transporter
CU254_20870	COG1609	Transcriptional regulator
CU254_20875	COG1175	transmembrane transport
CU254_20900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_20910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_20915	COG2301	Belongs to the HpcH HpaI aldolase family
CU254_20920	COG0477	Major facilitator Superfamily
CU254_20935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_20950	COG0604	alcohol dehydrogenase
CU254_20980	COG1733	regulation of RNA biosynthetic process
CU254_20990	COG0671	phosphoesterase, PA-phosphatase related
CU254_20995	COG0704	Plays a role in the regulation of phosphate uptake
CU254_21010	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_21015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU254_21020	COG1595	DNA-templated transcription, initiation
CU254_21045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU254_21050	COG0640	Transcriptional regulator
CU254_21055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU254_21060	COG1285	pathogenesis
CU254_21070	COG1116	anion transmembrane transporter activity
CU254_21075	COG2814	Major facilitator Superfamily
CU254_21110	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CU254_21125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CU254_21160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CU254_21170	COG3250	beta-galactosidase activity
CU254_21180	COG1695	Transcriptional regulator
CU254_21185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_21240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_21255	COG3285	dna ligase
CU254_21255	COG1793	dna ligase
CU254_21320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU254_21335	COG2815	serine threonine protein kinase
CU254_21335	COG0515	serine threonine protein kinase
CU254_21360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CU254_21370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CU254_21395	COG0028	Belongs to the TPP enzyme family
CU254_21435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_21470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU254_21475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU254_21480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU254_21485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU254_21490	COG1862	Preprotein translocase
CU254_21495	COG2255	four-way junction helicase activity
CU254_21500	COG0632	four-way junction helicase activity
CU254_21505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CU254_21520	COG0217	transcriptional regulatory protein
CU254_21525	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CU254_21530	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CU254_21545	COG2271	Major facilitator Superfamily
CU254_21555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_21565	COG3284	Transcriptional regulator
CU254_21570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_21605	COG1396	sequence-specific DNA binding
CU254_21630	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CU254_21630	COG3608	succinylglutamate desuccinylase aspartoacylase
CU254_21640	COG0438	transferase activity, transferring glycosyl groups
CU254_21645	COG1560	Kdo2-lipid A biosynthetic process
CU254_21655	COG1846	Transcriptional regulator
CU254_21665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU254_21670	COG0778	Nitroreductase
CU254_21675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CU254_21700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU254_21710	COG2124	cytochrome p450
CU254_21720	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_21725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU254_21730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU254_21745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU254_21765	COG3321	synthase
CU254_21765	COG0604	alcohol dehydrogenase
CU254_21785	COG2124	cytochrome p450
CU254_21825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_21845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_21865	COG0300	oxidoreductase activity
CU254_21885	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_21905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CU254_21910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CU254_21915	COG1024	Enoyl-CoA hydratase
CU254_21915	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_21940	COG0129	dihydroxy-acid dehydratase activity
CU254_21945	COG0762	integral membrane protein
CU254_21960	COG1335	isochorismatase
CU254_21965	COG1846	Transcriptional regulator
CU254_21970	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_21975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU254_21985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CU254_21995	COG0366	Alpha amylase catalytic
CU254_22000	COG0366	Alpha amylase catalytic
CU254_22010	COG2378	regulation of single-species biofilm formation
CU254_22065	COG1802	Transcriptional regulator
CU254_22120	COG1088	dTDP-glucose 4,6-dehydratase activity
CU254_22135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU254_22150	COG0714	Associated with various cellular activities
CU254_22160	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CU254_22175	COG0346	lactoylglutathione lyase activity
CU254_22185	COG5492	domain, Protein
CU254_22200	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_22205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_22210	COG1414	Transcriptional regulator
CU254_22215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU254_22265	COG1160	GTP binding
CU254_22270	COG0204	Acyl-transferase
CU254_22275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CU254_22290	COG0475	glutathione-regulated potassium exporter activity
CU254_22295	COG2936	dipeptidyl-peptidase activity
CU254_22305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CU254_22335	COG0504	CTP synthase activity
CU254_22340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CU254_22350	COG1802	Transcriptional regulator
CU254_22355	COG1953	Uracil, thiamine, allantoin
CU254_22410	COG0647	UMP catabolic process
CU254_22440	COG2094	Belongs to the DNA glycosylase MPG family
CU254_22445	COG0165	Argininosuccinate lyase
CU254_22450	COG0137	argininosuccinate synthase activity
CU254_22455	COG1438	arginine binding
CU254_22465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU254_22470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CU254_22475	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CU254_22480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CU254_22500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU254_22500	COG0072	phenylalanine-tRNA ligase activity
CU254_22505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CU254_22510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_22515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CU254_22520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CU254_22545	COG0251	oxidation-reduction process
CU254_22565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CU254_22570	COG2610	gluconate transmembrane transporter activity
CU254_22575	COG2706	6-phosphogluconolactonase activity
CU254_22600	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_22605	COG4565	transcriptional regulatory protein
CU254_22610	COG3290	protein histidine kinase activity
CU254_22615	COG1301	dicarboxylic acid transport
CU254_22620	COG1733	regulation of RNA biosynthetic process
CU254_22645	COG0328	RNA-DNA hybrid ribonuclease activity
CU254_22660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_22680	COG0328	RNA-DNA hybrid ribonuclease activity
CU254_22690	COG3012	SEC-C Motif Domain Protein
CU254_22695	COG3250	beta-galactosidase activity
CU254_22700	COG2272	Belongs to the type-B carboxylesterase lipase family
CU254_22705	COG0025	NhaP-type Na H and K H
CU254_22710	COG0406	alpha-ribazole phosphatase activity
CU254_22735	COG1070	Carbohydrate kinase
CU254_22740	COG1609	Transcriptional regulator
CU254_22755	COG1506	peptidase
CU254_22755	COG4946	Tricorn protease homolog
CU254_22755	COG0823	Involved in the tonB-independent uptake of proteins
CU254_22765	COG1131	(ABC) transporter
CU254_22775	COG1024	Enoyl-CoA hydratase
CU254_22810	COG1131	(ABC) transporter
CU254_22840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU254_22845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU254_22845	COG0237	dephospho-CoA kinase activity
CU254_22865	COG0539	negative regulation of cytoplasmic translation
CU254_22870	COG2226	methyltransferase
CU254_22885	COG1511	domain protein
CU254_22910	COG0411	ABC transporter
CU254_22975	COG3706	GGDEF domain
CU254_23000	COG1335	isochorismatase
CU254_23010	COG1285	pathogenesis
CU254_23025	COG2909	trisaccharide binding
CU254_23035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU254_23040	COG2197	response regulator
CU254_23075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CU254_23080	COG0163	prenyltransferase activity
CU254_23110	COG0300	oxidoreductase activity
CU254_23115	COG2409	Drug exporters of the RND superfamily
CU254_23120	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_23160	COG0612	Peptidase, M16
CU254_23170	COG1132	(ABC) transporter
CU254_23205	COG4585	Histidine kinase
CU254_23230	COG1414	Transcriptional regulator
CU254_23245	COG0402	S-adenosylhomocysteine deaminase activity
CU254_23265	COG1672	PFAM Archaeal ATPase
CU254_23265	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU254_23275	COG0667	Aldo Keto reductase
CU254_23290	COG1687	branched-chain amino acid
CU254_23295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CU254_23300	COG1522	sequence-specific DNA binding
CU254_23315	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_23370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU254_23385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_23415	COG0714	Associated with various cellular activities
CU254_23440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_23450	COG2072	flavoprotein involved in K transport
CU254_23455	COG0346	lactoylglutathione lyase activity
CU254_23470	COG3631	Ketosteroid isomerase-related protein
CU254_23485	COG1414	Transcriptional regulator
CU254_23490	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_23505	COG3546	catalase activity
CU254_23535	COG1309	transcriptional regulator
CU254_23545	COG1414	Transcriptional regulator
CU254_23550	COG0277	FAD linked oxidase domain protein
CU254_23550	COG0247	lactate metabolic process
CU254_23555	COG1454	alcohol dehydrogenase
CU254_23560	COG0477	Major facilitator Superfamily
CU254_23585	COG1659	Linocin_M18 bacteriocin protein
CU254_23610	COG0437	4 iron, 4 sulfur cluster binding
CU254_23615	COG3383	formate dehydrogenase (NAD+) activity
CU254_23615	COG0243	molybdopterin cofactor binding
CU254_23620	COG0243	molybdopterin cofactor binding
CU254_23620	COG3383	formate dehydrogenase (NAD+) activity
CU254_23630	COG1921	L-seryl-tRNASec selenium transferase activity
CU254_23640	COG0709	Synthesizes selenophosphate from selenide and ATP
CU254_23675	COG0651	ATP synthesis coupled electron transport
CU254_23720	COG0778	Nitroreductase
CU254_23720	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CU254_23745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU254_23765	COG1230	cation diffusion facilitator family transporter
CU254_23770	COG0739	heme binding
CU254_23810	COG2855	membrane
CU254_23830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_23855	COG3321	synthase
CU254_23855	COG0604	alcohol dehydrogenase
CU254_23855	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_23870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CU254_23875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CU254_23890	COG2267	carboxylic ester hydrolase activity
CU254_23905	COG1309	transcriptional regulator
CU254_23920	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_23925	COG1024	Enoyl-CoA hydratase
CU254_23935	COG0183	Belongs to the thiolase family
CU254_23945	COG1960	acyl-CoA dehydrogenase activity
CU254_23950	COG1024	Enoyl-CoA hydratase
CU254_23955	COG1960	acyl-CoA dehydrogenase activity
CU254_23960	COG1960	acyl-CoA dehydrogenase activity
CU254_23965	COG1960	acyl-CoA dehydrogenase activity
CU254_23985	COG1309	transcriptional regulator
CU254_23990	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_24000	COG0183	Belongs to the thiolase family
CU254_24010	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU254_24010	COG1902	pentaerythritol trinitrate reductase activity
CU254_24035	COG1309	transcriptional regulator
CU254_24045	COG2226	methyltransferase
CU254_24055	COG0583	DNA-binding transcription factor activity
CU254_24085	COG0581	inorganic phosphate transmembrane transporter activity
CU254_24095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU254_24100	COG2346	COG2346, Truncated hemoglobins
CU254_24105	COG1733	regulation of RNA biosynthetic process
CU254_24150	COG4638	Rieske (2fe-2S)
CU254_24155	COG0583	DNA-binding transcription factor activity
CU254_24165	COG3485	protocatechuate 3,4-dioxygenase
CU254_24170	COG4829	muconolactone delta-isomerase
CU254_24175	COG1136	(ABC) transporter
CU254_24180	COG1136	(ABC) transporter
CU254_24190	COG1024	Enoyl-CoA hydratase
CU254_24205	COG1960	acyl-CoA dehydrogenase activity
CU254_24210	COG1960	acyl-CoA dehydrogenase activity
CU254_24215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_24240	COG0583	DNA-binding transcription factor activity
CU254_24280	COG2267	carboxylic ester hydrolase activity
CU254_24295	COG0745	RESPONSE REGULATOR receiver
CU254_24300	COG2205	protein histidine kinase activity
CU254_24310	COG1309	transcriptional regulator
CU254_24315	COG0644	oxidoreductase
CU254_24340	COG0514	ATP-dependent DNA helicase (RecQ)
CU254_24355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CU254_24365	COG0542	response to heat
CU254_24370	COG0667	Aldo Keto reductase
CU254_24375	COG0494	nUDIX hydrolase
CU254_24390	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CU254_24395	COG1846	Transcriptional regulator
CU254_24395	COG1940	carbohydrate kinase activity
CU254_24420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_24450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CU254_24460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_24470	COG0640	Transcriptional regulator
CU254_24475	COG0768	penicillin binding
CU254_24480	COG1113	amino acid transport
CU254_24485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CU254_24505	COG0640	Transcriptional regulator
CU254_24525	COG1799	cell septum assembly
CU254_24530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CU254_24550	COG1595	DNA-templated transcription, initiation
CU254_24565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU254_24580	COG2318	DinB family
CU254_24605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CU254_24610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_24620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CU254_24625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU254_24645	COG0768	penicillin binding
CU254_24655	COG0275	rRNA processing
CU254_24660	COG2001	Belongs to the MraZ family
CU254_24685	COG0714	Associated with various cellular activities
CU254_24695	COG1305	Transglutaminase-like
CU254_24715	COG1192	Involved in chromosome partitioning
CU254_24720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU254_24735	COG0167	dihydroorotate dehydrogenase activity
CU254_24755	COG1396	sequence-specific DNA binding
CU254_24760	COG1546	Belongs to the CinA family
CU254_24760	COG1058	Belongs to the CinA family
CU254_24770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU254_24775	COG0464	growth
CU254_24785	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CU254_24795	COG1674	ftsk spoiiie
CU254_24810	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU254_24820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU254_24825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_24845	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CU254_24870	COG3214	Protein conserved in bacteria
CU254_24895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CU254_24900	COG0612	Peptidase, M16
CU254_24905	COG1185	polyribonucleotide nucleotidyltransferase activity
CU254_24910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CU254_24915	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CU254_24930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CU254_24940	COG0384	phenazine biosynthesis protein PhzF
CU254_24955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CU254_24970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CU254_24995	COG0779	Required for maturation of 30S ribosomal subunits
CU254_25030	COG3851	Histidine kinase
CU254_25035	COG2197	response regulator
CU254_25060	COG3976	FMN-binding domain protein
CU254_25060	COG1053	succinate dehydrogenase
CU254_25070	COG1846	Transcriptional regulator
CU254_25095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CU254_25105	COG1733	regulation of RNA biosynthetic process
CU254_25115	COG0745	RESPONSE REGULATOR receiver
CU254_25120	COG5002	protein histidine kinase activity
CU254_25125	COG1316	TRANSCRIPTIONal
CU254_25140	COG2814	Major facilitator Superfamily
CU254_25160	COG0583	DNA-binding transcription factor activity
CU254_25205	COG1674	ftsk spoiiie
CU254_25225	COG0464	growth
CU254_25290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_25310	COG1609	Transcriptional regulator
CU254_25320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_25325	COG3104	oligopeptide transport
CU254_25340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_25340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CU254_25345	COG1126	abc transporter atp-binding protein
CU254_25350	COG0765	amino acid transport
CU254_25380	COG2271	Major facilitator Superfamily
CU254_25390	COG3340	Belongs to the peptidase S51 family
CU254_25395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_25400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CU254_25425	COG1609	Transcriptional regulator
CU254_25440	COG2160	L-arabinose isomerase activity
CU254_25445	COG4213	ABC transporter substrate-binding protein
CU254_25450	COG1129	ABC transporter
CU254_25455	COG4214	carbohydrate transport
CU254_25505	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_25515	COG4977	sequence-specific DNA binding
CU254_25525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU254_25570	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_25595	COG1309	transcriptional regulator
CU254_25610	COG2423	ornithine cyclodeaminase activity
CU254_25620	COG0477	Major facilitator Superfamily
CU254_25625	COG1309	transcriptional regulator
CU254_25630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CU254_25680	COG0596	Alpha beta hydrolase
CU254_25710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CU254_25730	COG0789	Transcriptional regulator
CU254_25735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU254_25745	COG3973	AAA domain
CU254_25775	COG2084	Dehydrogenase
CU254_25785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_25790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CU254_25795	COG2080	2 iron, 2 sulfur cluster binding
CU254_25820	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_25880	COG1793	dna ligase
CU254_25880	COG3285	dna ligase
CU254_25955	COG1280	lysine exporter protein (LysE YggA)
CU254_25995	COG3345	alpha-galactosidase
CU254_26025	COG0477	Major facilitator Superfamily
CU254_26035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU254_26105	COG3246	L-lysine catabolic process to acetate
CU254_26110	COG0405	Gamma-glutamyltransferase
CU254_26155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CU254_26200	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_26260	COG1401	restriction endodeoxyribonuclease activity
CU254_26265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CU254_26275	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CU254_26320	COG4106	trans-aconitate 2-methyltransferase activity
CU254_26335	COG1595	DNA-templated transcription, initiation
CU254_26355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CU254_26365	COG2197	response regulator
CU254_26370	COG4585	Histidine kinase
CU254_26380	COG1131	(ABC) transporter
CU254_26385	COG0423	glycine-tRNA ligase activity
CU254_26420	COG0701	Predicted permease
CU254_26430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CU254_26435	COG1381	Involved in DNA repair and RecF pathway recombination
CU254_26460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CU254_26475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CU254_26485	COG0537	adenosine 5'-monophosphoramidase activity
CU254_26495	COG0484	heat shock protein binding
CU254_26500	COG1420	regulation of RNA biosynthetic process
CU254_26555	COG2205	protein histidine kinase activity
CU254_26560	COG0745	RESPONSE REGULATOR receiver
CU254_26565	COG1953	Uracil, thiamine, allantoin
CU254_26575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_26665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_26685	COG0604	alcohol dehydrogenase
CU254_26695	COG0531	amino acid
CU254_26715	COG0481	GTPase activity
CU254_26720	COG2226	methyltransferase
CU254_26735	COG0268	Binds directly to 16S ribosomal RNA
CU254_26745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CU254_26750	COG0658	competence protein
CU254_26750	COG2333	competence protein COMEC
CU254_26755	COG1555	photosystem II stabilization
CU254_26775	COG1307	EDD domain protein, DegV family
CU254_26780	COG2755	lipolytic protein G-D-S-L family
CU254_26785	COG0406	alpha-ribazole phosphatase activity
CU254_26790	COG0799	negative regulation of ribosome biogenesis
CU254_26795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CU254_26805	COG0477	Major facilitator Superfamily
CU254_26810	COG0018	arginyl-trna synthetase
CU254_26815	COG1309	transcriptional regulator
CU254_26820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_26825	COG1960	acyl-CoA dehydrogenase activity
CU254_26830	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_26835	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_26850	COG1309	transcriptional regulator
CU254_26860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CU254_26865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CU254_26870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CU254_26875	COG1530	ribonuclease E activity
CU254_26875	COG1530	ribonuclease E activity
CU254_26895	COG1131	(ABC) transporter
CU254_26920	COG0105	UTP biosynthetic process
CU254_26945	COG0285	dihydrofolate synthase activity
CU254_26965	COG0525	valine-tRNA ligase activity
CU254_26980	COG0477	Major facilitator Superfamily
CU254_26990	COG1316	TRANSCRIPTIONal
CU254_26995	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_27035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU254_27060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CU254_27065	COG0740	serine-type endopeptidase activity
CU254_27070	COG0740	serine-type endopeptidase activity
CU254_27075	COG0544	peptidyl-prolyl cis-trans isomerase activity
CU254_27085	COG2205	protein histidine kinase activity
CU254_27090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_27100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_27145	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_27160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU254_27165	COG0702	epimerase
CU254_27170	COG1733	regulation of RNA biosynthetic process
CU254_27180	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CU254_27185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_27200	COG1785	Belongs to the alkaline phosphatase family
CU254_27210	COG1940	carbohydrate kinase activity
CU254_27220	COG0017	Asparaginyl-tRNA synthetase
CU254_27225	COG1846	Transcriptional regulator
CU254_27230	COG2815	serine threonine protein kinase
CU254_27230	COG0515	serine threonine protein kinase
CU254_27240	COG0784	Response regulator, receiver
CU254_27240	COG5002	protein histidine kinase activity
CU254_27285	COG0667	Aldo Keto reductase
CU254_27340	COG3629	intracellular signal transduction
CU254_27340	COG3903	Transcriptional regulator
CU254_27365	COG2271	Major facilitator Superfamily
CU254_27370	COG0251	oxidation-reduction process
CU254_27390	COG1012	belongs to the aldehyde dehydrogenase family
CU254_27395	COG0583	DNA-binding transcription factor activity
CU254_27410	COG2197	response regulator
CU254_27415	COG4585	Histidine kinase
CU254_27430	COG0456	acetyltransferase
CU254_27440	COG1309	transcriptional regulator
CU254_27480	COG2814	Major facilitator Superfamily
CU254_27495	COG1846	Transcriptional regulator
CU254_27520	COG0698	ribose 5-phosphate isomerase
CU254_27535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU254_27545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CU254_27565	COG0668	transmembrane transport
CU254_27575	COG0366	Alpha amylase catalytic
CU254_27585	COG1278	Cold shock
CU254_27615	COG2902	Dehydrogenase
CU254_27635	COG1609	Transcriptional regulator
CU254_27760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_27765	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_27770	COG2072	flavoprotein involved in K transport
CU254_27800	COG3511	phospholipase C
CU254_27805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_27810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_27820	COG1960	acyl-CoA dehydrogenase activity
CU254_27855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_27885	COG3795	YCII-related domain
CU254_27900	COG0009	L-threonylcarbamoyladenylate synthase
CU254_27905	COG1285	pathogenesis
CU254_27915	COG1937	Protein conserved in bacteria
CU254_27960	COG4941	Belongs to the sigma-70 factor family
CU254_27965	COG0596	Alpha beta hydrolase
CU254_27970	COG0596	Alpha beta hydrolase
CU254_27975	COG4221	oxidoreductase activity
CU254_27985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CU254_28020	COG1309	transcriptional regulator
CU254_28085	COG0745	RESPONSE REGULATOR receiver
CU254_28090	COG0642	Histidine kinase
CU254_28095	COG0531	amino acid
CU254_28100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_28140	COG2801	Transposase and inactivated derivatives
CU254_28165	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_28170	COG1024	Enoyl-CoA hydratase
CU254_28205	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_28215	COG1643	Atp-dependent helicase
CU254_28220	COG0475	glutathione-regulated potassium exporter activity
CU254_28240	COG1796	DNA polymerase
CU254_28240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CU254_28250	COG1802	Transcriptional regulator
CU254_28285	COG3795	YCII-related domain
CU254_28295	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CU254_28300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_28320	COG1609	Transcriptional regulator
CU254_28340	COG2233	PERMEase
CU254_28345	COG0163	prenyltransferase activity
CU254_28350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CU254_28355	COG0523	cobalamin synthesis protein
CU254_28365	COG0235	Class ii aldolase
CU254_28365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CU254_28390	COG1846	Transcriptional regulator
CU254_28395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_28400	COG0477	Major facilitator Superfamily
CU254_28425	COG1739	Uncharacterized protein family UPF0029
CU254_28430	COG0069	glutamate synthase activity
CU254_28430	COG0067	glutamate synthase
CU254_28430	COG0070	glutamate synthase
CU254_28440	COG1228	amidohydrolase
CU254_28445	COG0477	Major facilitator Superfamily
CU254_28450	COG0583	DNA-binding transcription factor activity
CU254_28470	COG3851	Histidine kinase
CU254_28475	COG2197	response regulator
CU254_28485	COG1492	cobalamin metabolic process
CU254_28490	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CU254_28500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CU254_28510	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CU254_28525	COG1797	cobyrinic acid a,c-diamide synthase activity
CU254_28560	COG0778	Nitroreductase
CU254_28600	COG1131	(ABC) transporter
CU254_28610	COG1476	TRANSCRIPTIONal
CU254_28620	COG3469	chitinase activity
CU254_28625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU254_28625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU254_28630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CU254_28670	COG2226	methyltransferase
CU254_28685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU254_28695	COG0433	COG0433 Predicted ATPase
CU254_28700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CU254_28755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CU254_28795	COG2366	antibiotic biosynthetic process
CU254_28810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU254_28840	COG2197	response regulator
CU254_28905	COG3033	Beta-eliminating lyase
CU254_28925	COG1309	transcriptional regulator
CU254_28965	COG0542	response to heat
CU254_28980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CU254_28985	COG0443	Heat shock 70 kDa protein
CU254_29055	COG2814	Major facilitator Superfamily
CU254_29060	COG0488	(ABC) transporter
CU254_29120	COG0444	Belongs to the ABC transporter superfamily
CU254_29125	COG4608	Belongs to the ABC transporter superfamily
CU254_29135	COG4166	transmembrane transport
CU254_29140	COG1363	Peptidase, m42
CU254_29200	COG2197	response regulator
CU254_29210	COG4585	Histidine kinase
CU254_29225	COG2124	cytochrome p450
CU254_29225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CU254_29230	COG1309	transcriptional regulator
CU254_29250	COG3842	ATPase activity
CU254_29265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_29300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_29305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_29310	COG0473	3-isopropylmalate dehydrogenase activity
CU254_29310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_29315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_29320	COG3384	dioxygenase
CU254_29325	COG2159	amidohydrolase
CU254_29330	COG2368	4-hydroxyphenylacetate
CU254_29340	COG0028	Belongs to the TPP enzyme family
CU254_29345	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_29355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU254_29395	COG1335	isochorismatase
CU254_29405	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_29415	COG1802	Transcriptional regulator
CU254_29430	COG0477	Major facilitator Superfamily
CU254_29435	COG1309	transcriptional regulator
CU254_29460	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_29480	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_29490	COG3835	regulator
CU254_29505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_29505	COG2010	Cytochrome c
CU254_29510	COG2080	2 iron, 2 sulfur cluster binding
CU254_29530	COG0022	dehydrogenase e1 component
CU254_29535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU254_29545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_29580	COG1131	(ABC) transporter
CU254_29585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_29610	COG1802	Transcriptional regulator
CU254_29615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_29620	COG1012	belongs to the aldehyde dehydrogenase family
CU254_29630	COG4977	sequence-specific DNA binding
CU254_29655	COG0411	ABC transporter
CU254_29720	COG1012	belongs to the aldehyde dehydrogenase family
CU254_29740	COG0402	S-adenosylhomocysteine deaminase activity
CU254_29745	COG0667	Aldo Keto reductase
CU254_29760	COG1595	DNA-templated transcription, initiation
CU254_29770	COG0640	Transcriptional regulator
CU254_29795	COG1522	sequence-specific DNA binding
CU254_29820	COG1012	belongs to the aldehyde dehydrogenase family
CU254_29825	COG3284	Transcriptional regulator
CU254_29840	COG1846	Transcriptional regulator
CU254_29845	COG0488	(ABC) transporter
CU254_29850	COG0488	(ABC) transporter
CU254_29865	COG4260	virion core protein, lumpy skin disease virus
CU254_29875	COG2264	protein methyltransferase activity
CU254_29890	COG3903	Transcriptional regulator
CU254_29890	COG3629	intracellular signal transduction
CU254_29900	COG3903	Transcriptional regulator
CU254_29900	COG3629	intracellular signal transduction
CU254_29910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CU254_29930	COG1215	transferase activity, transferring glycosyl groups
CU254_29940	COG0137	argininosuccinate synthase activity
CU254_29960	COG2267	carboxylic ester hydrolase activity
CU254_29965	COG1309	transcriptional regulator
CU254_29970	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CU254_29975	COG2188	Transcriptional regulator
CU254_30020	COG4941	Belongs to the sigma-70 factor family
CU254_30040	COG1234	tRNA 3'-trailer cleavage
CU254_30045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU254_30060	COG1309	transcriptional regulator
CU254_30095	COG3321	synthase
CU254_30095	COG0604	alcohol dehydrogenase
CU254_30110	COG0577	efflux transmembrane transporter activity
CU254_30110	COG1136	(ABC) transporter
CU254_30135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_30215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_30230	COG2267	carboxylic ester hydrolase activity
CU254_30245	COG2197	response regulator
CU254_30255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_30280	COG1522	sequence-specific DNA binding
CU254_30315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_30320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_30340	COG2226	methyltransferase
CU254_30345	COG2226	methyltransferase
CU254_30350	COG1070	Carbohydrate kinase
CU254_30365	COG1595	DNA-templated transcription, initiation
CU254_30405	COG0242	peptide deformylase activity
CU254_30415	COG1024	Enoyl-CoA hydratase
CU254_30495	COG2226	methyltransferase
CU254_30510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_30515	COG1522	sequence-specific DNA binding
CU254_30525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_30555	COG0747	negative chemotaxis
CU254_30560	COG0601	transmembrane transport
CU254_30565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_30570	COG4172	Belongs to the ABC transporter superfamily
CU254_30590	COG3511	phospholipase C
CU254_30595	COG2837	iron assimilation
CU254_30600	COG2822	iron ion transport
CU254_30610	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_30620	COG1929	Belongs to the glycerate kinase type-1 family
CU254_30630	COG2252	PERMEase
CU254_30635	COG0590	tRNA wobble adenosine to inosine editing
CU254_30645	COG3835	regulator
CU254_30665	COG1228	amidohydrolase
CU254_30685	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_30695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CU254_30705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_30715	COG1733	regulation of RNA biosynthetic process
CU254_30740	COG1280	lysine exporter protein (LysE YggA)
CU254_30755	COG1408	metallophosphoesterase
CU254_30765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_30770	COG1051	belongs to the nudix hydrolase family
CU254_30790	COG2018	Roadblock/LC7 domain
CU254_30795	COG0642	Histidine kinase
CU254_30805	COG3844	kynureninase activity
CU254_30815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU254_30840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU254_30845	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_30855	COG0745	RESPONSE REGULATOR receiver
CU254_30855	COG3706	GGDEF domain
CU254_30865	COG1316	TRANSCRIPTIONal
CU254_30910	COG0789	Transcriptional regulator
CU254_30935	COG1309	transcriptional regulator
CU254_30945	COG0583	DNA-binding transcription factor activity
CU254_30975	COG5002	protein histidine kinase activity
CU254_30980	COG0745	RESPONSE REGULATOR receiver
CU254_30985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CU254_30990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CU254_31000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CU254_31055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CU254_31060	COG1335	isochorismatase
CU254_31070	COG1268	BioY protein
CU254_31100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU254_31110	COG2267	carboxylic ester hydrolase activity
CU254_31120	COG0477	Major facilitator Superfamily
CU254_31145	COG0626	cystathionine gamma-synthase activity
CU254_31155	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_31160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU254_31170	COG2376	Dihydroxyacetone kinase
CU254_31200	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU254_31205	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CU254_31215	COG1024	Enoyl-CoA hydratase
CU254_31220	COG4977	sequence-specific DNA binding
CU254_31250	COG1280	lysine exporter protein (LysE YggA)
CU254_31260	COG0702	epimerase
CU254_31265	COG3631	Ketosteroid isomerase-related protein
CU254_31295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CU254_31300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CU254_31305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CU254_31310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CU254_31320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CU254_31325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CU254_31330	COG0356	it plays a direct role in the translocation of protons across the membrane
CU254_31340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU254_31365	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_31370	COG0789	Transcriptional regulator
CU254_31375	COG0596	Alpha beta hydrolase
CU254_31380	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_31385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_31395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CU254_31400	COG0254	rRNA binding
CU254_31415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CU254_31420	COG0083	homoserine kinase activity
CU254_31425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CU254_31430	COG0460	homoserine dehydrogenase
CU254_31435	COG0019	diaminopimelate decarboxylase activity
CU254_31440	COG0018	arginyl-trna synthetase
CU254_31460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_31470	COG0596	Alpha beta hydrolase
CU254_31485	COG2814	Major facilitator Superfamily
CU254_31490	COG1953	Uracil, thiamine, allantoin
CU254_31525	COG3903	Transcriptional regulator
CU254_31525	COG3629	intracellular signal transduction
CU254_31535	COG0402	S-adenosylhomocysteine deaminase activity
CU254_31545	COG0477	Major facilitator Superfamily
CU254_31550	COG0277	FAD linked oxidase domain protein
CU254_31570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CU254_31590	COG3226	Transcriptional regulator
CU254_31610	COG0583	DNA-binding transcription factor activity
CU254_31620	COG2132	Multicopper oxidase
CU254_31625	COG2197	response regulator
CU254_31660	COG2072	flavoprotein involved in K transport
CU254_31670	COG1595	DNA-templated transcription, initiation
CU254_31675	COG1252	NADH dehydrogenase
CU254_31680	COG0454	-acetyltransferase
CU254_31685	COG0488	(ABC) transporter
CU254_31695	COG2226	methyltransferase
CU254_31720	COG0159	tryptophan synthase activity
CU254_31740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_31750	COG2197	response regulator
CU254_31755	COG4585	Histidine kinase
CU254_31800	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_31805	COG3835	regulator
CU254_31815	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_31820	COG0583	DNA-binding transcription factor activity
CU254_31850	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_31950	COG0477	Major facilitator Superfamily
CU254_31955	COG1802	Transcriptional regulator
CU254_31985	COG0667	Aldo Keto reductase
CU254_32000	COG0154	amidase activity
CU254_32020	COG2186	Transcriptional regulator
CU254_32035	COG0473	3-isopropylmalate dehydrogenase activity
CU254_32060	COG0028	Belongs to the TPP enzyme family
CU254_32090	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_32090	COG1024	Enoyl-CoA hydratase
CU254_32095	COG0183	Belongs to the thiolase family
CU254_32100	COG1309	transcriptional regulator
CU254_32115	COG1960	acyl-CoA dehydrogenase activity
CU254_32145	COG1733	regulation of RNA biosynthetic process
CU254_32160	COG3243	poly(R)-hydroxyalkanoic acid synthase
CU254_32165	COG4221	oxidoreductase activity
CU254_32175	COG1960	acyl-CoA dehydrogenase activity
CU254_32185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_32195	COG1309	transcriptional regulator
CU254_32205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_32235	COG0686	Belongs to the AlaDH PNT family
CU254_32240	COG1132	(ABC) transporter
CU254_32270	COG0567	Dehydrogenase, E1 component
CU254_32270	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU254_32305	COG1174	glycine betaine transport
CU254_32310	COG1174	glycine betaine transport
CU254_32315	COG0517	IMP dehydrogenase activity
CU254_32315	COG1125	glycine betaine transport
CU254_32330	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CU254_32345	COG0406	alpha-ribazole phosphatase activity
CU254_32355	COG0596	Alpha beta hydrolase
CU254_32365	COG1597	lipid kinase activity
CU254_32390	COG1595	DNA-templated transcription, initiation
CU254_32395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CU254_32400	COG2226	methyltransferase
CU254_32410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_32430	COG2135	peptidase activity
CU254_32435	COG1162	GTPase activity
CU254_32465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_32470	COG1011	Hydrolase
CU254_32480	COG0653	protein targeting
CU254_32485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CU254_32495	COG5401	PFAM Sporulation and spore germination
CU254_32500	COG5002	protein histidine kinase activity
CU254_32505	COG0745	RESPONSE REGULATOR receiver
CU254_32510	COG1414	Transcriptional regulator
CU254_32530	COG1309	transcriptional regulator
CU254_32550	COG0442	prolyl-tRNA aminoacylation
CU254_32570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CU254_32585	COG0531	amino acid
CU254_32595	COG3620	sequence-specific DNA binding
CU254_32605	COG1482	cell wall glycoprotein biosynthetic process
CU254_32650	COG1994	Peptidase M50
CU254_32665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_32670	COG0747	negative chemotaxis
CU254_32675	COG0601	transmembrane transport
CU254_32690	COG4608	Belongs to the ABC transporter superfamily
CU254_32695	COG0747	negative chemotaxis
CU254_32715	COG0180	Tryptophanyl-tRNA synthetase
CU254_32725	COG2205	protein histidine kinase activity
CU254_32730	COG0745	RESPONSE REGULATOR receiver
CU254_32740	COG1131	(ABC) transporter
CU254_32750	COG3842	ATPase activity
CU254_32765	COG2154	pterin-4-alpha-carbinolamine dehydratase
CU254_32785	COG0012	GTP binding
CU254_32800	COG0419	ATPase involved in DNA repair
CU254_32805	COG0420	3'-5' exonuclease activity
CU254_32820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CU254_32830	COG1570	exodeoxyribonuclease VII activity
CU254_32840	COG1722	exodeoxyribonuclease VII activity
CU254_32855	COG0492	ferredoxin-NADP+ reductase activity
CU254_32860	COG0114	fumarate hydratase activity
CU254_32870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_32915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CU254_32945	COG1331	Highly conserved protein containing a thioredoxin domain
CU254_32975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_32985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU254_32990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_32995	COG1522	sequence-specific DNA binding
CU254_33000	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CU254_33030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU254_33070	COG0183	Belongs to the thiolase family
CU254_33075	COG0477	Major facilitator Superfamily
CU254_33155	COG1175	transmembrane transport
CU254_33165	COG2197	response regulator
CU254_33170	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_33190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_33195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CU254_33230	COG1175	transmembrane transport
CU254_33235	COG0395	ABC-type sugar transport system, permease component
CU254_33270	COG1876	peptidase activity
CU254_33295	COG0671	phosphoesterase, PA-phosphatase related
CU254_33315	COG0726	polysaccharide deacetylase
CU254_33325	COG1316	TRANSCRIPTIONal
CU254_33350	COG1414	Transcriptional regulator
CU254_33355	COG3591	Belongs to the peptidase S1B family
CU254_33360	COG0154	amidase activity
CU254_33430	COG2508	Transcriptional regulator
CU254_33430	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CU254_33435	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_33450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CU254_33465	COG2271	Major facilitator Superfamily
CU254_33470	COG2272	Belongs to the type-B carboxylesterase lipase family
CU254_33490	COG3239	Fatty acid desaturase
CU254_33505	COG2814	Major facilitator Superfamily
CU254_33515	COG1252	NADH dehydrogenase
CU254_33530	COG2197	response regulator
CU254_33540	COG1131	(ABC) transporter
CU254_33555	COG0596	Alpha beta hydrolase
CU254_33565	COG4608	Belongs to the ABC transporter superfamily
CU254_33570	COG0444	Belongs to the ABC transporter superfamily
CU254_33575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_33595	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_33600	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_33605	COG0583	DNA-binding transcription factor activity
CU254_33630	COG0148	phosphopyruvate hydratase activity
CU254_33655	COG0672	)-iron permease
CU254_33665	COG2837	iron assimilation
CU254_33670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_33690	COG1131	(ABC) transporter
CU254_33705	COG3956	TIGRFAM MazG family protein
CU254_33725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_33735	COG0586	Pfam SNARE associated Golgi protein
CU254_33745	COG4585	Histidine kinase
CU254_33750	COG2197	response regulator
CU254_33755	COG2133	pyrroloquinoline quinone binding
CU254_33760	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_33780	COG1309	transcriptional regulator
CU254_33800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CU254_33820	COG1309	transcriptional regulator
CU254_33845	COG0193	aminoacyl-tRNA hydrolase activity
CU254_33855	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_33860	COG0488	(ABC) transporter
CU254_33865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CU254_33875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CU254_33880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU254_33885	COG3583	domain protein
CU254_33890	COG0084	hydrolase, TatD family'
CU254_33895	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU254_33955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU254_33980	COG2258	MOSC domain
CU254_33990	COG1012	belongs to the aldehyde dehydrogenase family
CU254_34050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_34055	COG2197	response regulator
CU254_34090	COG1902	pentaerythritol trinitrate reductase activity
CU254_34095	COG2267	carboxylic ester hydrolase activity
CU254_34100	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_34110	COG0583	DNA-binding transcription factor activity
CU254_34125	COG0583	DNA-binding transcription factor activity
CU254_34135	COG3209	COG3209 Rhs family protein
CU254_34175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU254_34185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CU254_34190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CU254_34215	COG0521	Mo-molybdopterin cofactor biosynthetic process
CU254_34215	COG0315	cyclic pyranopterin monophosphate synthase activity
CU254_34230	COG5002	protein histidine kinase activity
CU254_34235	COG0745	RESPONSE REGULATOR receiver
CU254_34280	COG1349	DNA-binding transcription factor activity
CU254_34295	COG2860	membrane
CU254_34300	COG2197	response regulator
CU254_34335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU254_34375	COG0477	Major facilitator Superfamily
CU254_34380	COG0702	epimerase
CU254_34485	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_34495	COG1960	acyl-CoA dehydrogenase activity
CU254_34505	COG0583	DNA-binding transcription factor activity
CU254_34530	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU254_34550	COG0275	rRNA processing
CU254_34580	COG3285	dna ligase
CU254_34580	COG1793	dna ligase
CU254_34595	COG0583	DNA-binding transcription factor activity
CU254_34635	COG1960	acyl-CoA dehydrogenase activity
CU254_34660	COG4336	lyase activity
CU254_34665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CU254_34675	COG1984	allophanate hydrolase subunit 2
CU254_34680	COG3145	DNA-N1-methyladenine dioxygenase activity
CU254_34700	COG1321	iron dependent repressor
CU254_34715	COG1024	Enoyl-CoA hydratase
CU254_34720	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_34740	COG1169	isochorismate synthase
CU254_34755	COG2182	Extracellular solute-binding protein
CU254_34760	COG4208	sulfate ABC transporter
CU254_34765	COG0395	ABC-type sugar transport system, permease component
CU254_34810	COG0277	FAD linked oxidase domain protein
CU254_34835	COG4152	abc transporter atp-binding protein
CU254_34840	COG1668	transmembrane transport
CU254_34855	COG0415	Belongs to the DNA photolyase family
CU254_34865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CU254_34865	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CU254_34875	COG1960	acyl-CoA dehydrogenase activity
CU254_34880	COG1733	regulation of RNA biosynthetic process
CU254_34895	COG1228	amidohydrolase
CU254_34910	COG1309	transcriptional regulator
CU254_34925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CU254_34930	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_34940	COG1113	amino acid transport
CU254_34945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_34950	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CU254_34955	COG0028	Belongs to the TPP enzyme family
CU254_34980	COG0259	pyridoxamine-phosphate oxidase activity
CU254_34990	COG0829	nickel cation binding
CU254_34995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CU254_35005	COG0804	urea catabolic process
CU254_35010	COG0832	Belongs to the urease beta subunit family
CU254_35015	COG0831	urea catabolic process
CU254_35045	COG4585	Histidine kinase
CU254_35055	COG1609	Transcriptional regulator
CU254_35060	COG1397	ADP-ribosylglycohydrolase
CU254_35100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_35115	COG5398	heme oxygenase
CU254_35130	COG2814	Major facilitator Superfamily
CU254_35140	COG2252	PERMEase
CU254_35165	COG2814	Major facilitator Superfamily
CU254_35175	COG1278	Cold shock
CU254_35195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU254_35200	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_35215	COG3304	Inner membrane component domain
CU254_35230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CU254_35265	COG1846	Transcriptional regulator
CU254_35315	COG2018	Roadblock/LC7 domain
CU254_35330	COG2018	Roadblock/LC7 domain
CU254_35340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU254_35350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU254_35355	COG1116	anion transmembrane transporter activity
CU254_35355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU254_35375	COG3142	Participates in the control of copper homeostasis
CU254_35395	COG1061	Type III restriction enzyme res subunit
CU254_35415	COG3903	Transcriptional regulator
CU254_35415	COG2319	Wd-40 repeat
CU254_35420	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_35430	COG0459	protein refolding
CU254_35440	COG1278	Cold shock
CU254_35465	COG2261	transglycosylase associated protein
CU254_35475	COG0688	phosphatidylethanolamine metabolic process
CU254_35490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU254_35505	COG0242	peptide deformylase activity
CU254_35510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CU254_35515	COG0351	phosphomethylpyrimidine kinase
CU254_35550	COG2022	thiamine diphosphate biosynthetic process
CU254_35565	COG0352	thiamine-phosphate diphosphorylase activity
CU254_35575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU254_35595	COG0477	Major facilitator Superfamily
CU254_35600	COG2188	Transcriptional regulator
CU254_35605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU254_35620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CU254_35650	COG3629	intracellular signal transduction
CU254_35650	COG3903	Transcriptional regulator
CU254_35655	COG5285	phytanoyl-CoA dioxygenase
CU254_35660	COG1917	Cupin 2, conserved barrel domain protein
CU254_35670	COG0456	acetyltransferase
CU254_35675	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU254_35680	COG4399	Belongs to the UPF0754 family
CU254_35695	COG5416	Lipopolysaccharide assembly protein A domain
CU254_35715	COG1733	regulation of RNA biosynthetic process
CU254_35770	COG0346	lactoylglutathione lyase activity
CU254_35780	COG1832	CoA-binding protein
CU254_35790	COG0745	RESPONSE REGULATOR receiver
CU254_35795	COG2205	protein histidine kinase activity
CU254_35800	COG1492	cobalamin metabolic process
CU254_35805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CU254_35810	COG1414	Transcriptional regulator
CU254_35815	COG4941	Belongs to the sigma-70 factor family
CU254_35825	COG3795	YCII-related domain
CU254_35840	COG2124	cytochrome p450
CU254_35845	COG0596	Alpha beta hydrolase
CU254_35850	COG1946	Acyl-CoA thioesterase
CU254_35875	COG4566	intracellular signal transduction
CU254_35895	COG3852	Histidine kinase
CU254_35910	COG4638	Rieske (2fe-2S)
CU254_35930	COG0477	Major facilitator Superfamily
CU254_36005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CU254_36015	COG1329	Transcriptional regulator
CU254_36020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CU254_36025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CU254_36045	COG0215	cysteine-tRNA ligase activity
CU254_36050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_36070	COG0235	Class ii aldolase
CU254_36080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CU254_36085	COG0698	ribose 5-phosphate isomerase
CU254_36090	COG2376	Dihydroxyacetone kinase
CU254_36095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_36100	COG0406	alpha-ribazole phosphatase activity
CU254_36105	COG1349	DNA-binding transcription factor activity
CU254_36110	COG2814	Major facilitator Superfamily
CU254_36115	COG1070	Carbohydrate kinase
CU254_36135	COG4399	Belongs to the UPF0754 family
CU254_36155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU254_36160	COG1120	ATPase activity
CU254_36165	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU254_36170	COG1609	Transcriptional regulator
CU254_36180	COG1194	a g-specific adenine glycosylase
CU254_36250	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CU254_36255	COG0443	Heat shock 70 kDa protein
CU254_36265	COG0542	response to heat
CU254_36290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CU254_36300	COG2076	Multidrug Resistance protein
CU254_36305	COG1595	DNA-templated transcription, initiation
CU254_36315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CU254_36320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CU254_36325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CU254_36350	COG0789	Transcriptional regulator
CU254_36375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU254_36420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CU254_36430	COG3795	YCII-related domain
CU254_36435	COG4941	Belongs to the sigma-70 factor family
CU254_36440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CU254_36465	COG0640	Transcriptional regulator
CU254_36495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CU254_36500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CU254_36515	COG2223	nitrite transmembrane transporter activity
CU254_36520	COG1754	DNA topoisomerase type I activity
CU254_36520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU254_36545	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CU254_36550	COG1111	helicase
CU254_36550	COG1205	dead DEAH box helicase
CU254_36600	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_36605	COG3876	Protein conserved in bacteria
CU254_36610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU254_36615	COG1737	Transcriptional regulator
CU254_36620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CU254_36625	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CU254_36630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_36635	COG1595	DNA-templated transcription, initiation
CU254_36640	COG0667	Aldo Keto reductase
CU254_36660	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_36670	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CU254_36680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_36735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_36755	COG1902	pentaerythritol trinitrate reductase activity
CU254_36765	COG3104	oligopeptide transport
CU254_36770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CU254_36780	COG0596	Alpha beta hydrolase
CU254_36835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_36885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_36890	COG1408	metallophosphoesterase
CU254_36915	COG0076	glutamate decarboxylase activity
CU254_36920	COG0783	Belongs to the Dps family
CU254_36925	COG1764	response to oxidative stress
CU254_36930	COG0431	NADPH-dependent FMN reductase
CU254_36955	COG1690	Belongs to the RtcB family
CU254_37005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_37015	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_37025	COG0583	DNA-binding transcription factor activity
CU254_37030	COG0697	spore germination
CU254_37040	COG0586	Pfam SNARE associated Golgi protein
CU254_37045	COG4941	Belongs to the sigma-70 factor family
CU254_37060	COG4608	Belongs to the ABC transporter superfamily
CU254_37065	COG0444	Belongs to the ABC transporter superfamily
CU254_37080	COG0747	negative chemotaxis
CU254_37100	COG0463	Glycosyl transferase, family 2
CU254_37115	COG1215	transferase activity, transferring glycosyl groups
CU254_37120	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU254_37130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CU254_37135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CU254_37140	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU254_37180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU254_37185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_37190	COG2205	protein histidine kinase activity
CU254_37195	COG0745	RESPONSE REGULATOR receiver
CU254_37220	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_37270	COG0477	Major facilitator Superfamily
CU254_37295	COG1674	ftsk spoiiie
CU254_37310	COG2843	Capsule synthesis protein
CU254_37315	COG2267	carboxylic ester hydrolase activity
CU254_37325	COG2175	clavaminate synthase activity
CU254_37340	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_37370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_37440	COG0596	Alpha beta hydrolase
CU254_37445	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CU254_37450	COG3706	GGDEF domain
CU254_37465	COG1316	TRANSCRIPTIONal
CU254_37475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CU254_37500	COG0745	RESPONSE REGULATOR receiver
CU254_37535	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CU254_37545	COG1984	allophanate hydrolase subunit 2
CU254_37565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CU254_37605	COG3845	ABC transporter
CU254_37690	COG0778	Nitroreductase
CU254_37700	COG1132	(ABC) transporter
CU254_37705	COG1132	(ABC) transporter
CU254_37720	COG0047	phosphoribosylformylglycinamidine synthase activity
CU254_37725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CU254_37795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CU254_37820	COG0765	amino acid transport
CU254_37835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CU254_37850	COG0800	Aldolase
CU254_37900	COG1011	Hydrolase
CU254_37910	COG0436	Aminotransferase
CU254_37915	COG5280	Phage tail tape measure protein TP901
CU254_37915	COG3953	SLT domain
CU254_37950	COG0584	glycerophosphoryl diester phosphodiesterase
CU254_37970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_37985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CU254_38015	COG0745	RESPONSE REGULATOR receiver
CU254_38015	COG3706	GGDEF domain
CU254_38020	COG2153	protein acetylation
CU254_38045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_38060	COG0667	Aldo Keto reductase
CU254_38065	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_38120	COG0586	Pfam SNARE associated Golgi protein
CU254_38125	COG0277	FAD linked oxidase domain protein
CU254_38130	COG0500	methyltransferase
CU254_38140	COG1309	transcriptional regulator
CU254_38145	COG0477	Major facilitator Superfamily
CU254_38155	COG3467	pyridoxamine 5'-phosphate
CU254_38175	COG0586	Pfam SNARE associated Golgi protein
CU254_38195	COG0572	uridine kinase
CU254_38200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_38220	COG1609	Transcriptional regulator
CU254_38235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_38275	COG1136	(ABC) transporter
CU254_38275	COG0577	efflux transmembrane transporter activity
CU254_38280	COG0300	oxidoreductase activity
CU254_38295	COG2826	transposase and inactivated derivatives, IS30 family
CU254_38310	COG0542	response to heat
CU254_38345	COG0789	Transcriptional regulator
CU254_38350	COG0484	heat shock protein binding
CU254_38355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CU254_38360	COG0443	Heat shock 70 kDa protein
CU254_38400	COG0247	lactate metabolic process
CU254_38400	COG2181	nitrate reductase activity
CU254_38410	COG2340	Cysteine-rich secretory protein family
CU254_38415	COG0574	Belongs to the PEP-utilizing enzyme family
CU254_38415	COG3848	Pyruvate phosphate dikinase
CU254_38425	COG1846	Transcriptional regulator
CU254_38435	COG0717	Belongs to the dCTP deaminase family
CU254_38485	COG1960	acyl-CoA dehydrogenase activity
CU254_38490	COG2197	response regulator
CU254_38500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU254_38510	COG1525	nuclease
CU254_38510	COG4085	toxin activity
CU254_38510	COG0737	Belongs to the 5'-nucleotidase family
CU254_38520	COG2720	vancomycin resistance protein
CU254_38525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CU254_38575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_38590	COG1305	Transglutaminase-like
CU254_38595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_38600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_38610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_38620	COG0022	dehydrogenase e1 component
CU254_38625	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU254_38640	COG4133	protoheme IX ABC transporter activity
CU254_38650	COG3030	protein affecting phage T7 exclusion by the F plasmid
CU254_38675	COG1309	transcriptional regulator
CU254_38680	COG2030	dehydratase
CU254_38685	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_38690	COG0183	Belongs to the thiolase family
CU254_38710	COG0456	acetyltransferase
CU254_38730	COG2826	transposase and inactivated derivatives, IS30 family
CU254_38765	COG1131	(ABC) transporter
CU254_38775	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CU254_38820	COG4585	Histidine kinase
CU254_38825	COG2197	response regulator
CU254_38840	COG1131	(ABC) transporter
CU254_38855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CU254_38865	COG1136	(ABC) transporter
CU254_38875	COG2197	response regulator
CU254_38880	COG0402	S-adenosylhomocysteine deaminase activity
CU254_38885	COG4221	oxidoreductase activity
CU254_38890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_38905	COG2814	Major facilitator Superfamily
CU254_38915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_38925	COG1695	Transcriptional regulator
CU254_38935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_38940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_38945	COG0673	inositol 2-dehydrogenase activity
CU254_38950	COG1940	carbohydrate kinase activity
CU254_38985	COG0360	Binds together with S18 to 16S ribosomal RNA
CU254_38995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CU254_39000	COG0359	binds to the 23S rRNA
CU254_39030	COG0640	Transcriptional regulator
CU254_39045	COG3384	dioxygenase
CU254_39085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU254_39090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_39100	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_39120	COG0495	leucyl-tRNA aminoacylation
CU254_39135	COG1678	Uncharacterized ACR, COG1678
CU254_39170	COG4585	Histidine kinase
CU254_39175	COG0617	tRNA 3'-terminal CCA addition
CU254_39200	COG1595	DNA-templated transcription, initiation
CU254_39215	COG3118	belongs to the thioredoxin family
CU254_39215	COG0492	ferredoxin-NADP+ reductase activity
CU254_39220	COG3409	Peptidoglycan-binding domain 1 protein
CU254_39220	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU254_39235	COG1181	Belongs to the D-alanine--D-alanine ligase family
CU254_39245	COG1192	Involved in chromosome partitioning
CU254_39250	COG0357	Ribosomal RNA small subunit methyltransferase G
CU254_39260	COG0706	membrane insertase activity
CU254_39265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CU254_39270	COG0594	ribonuclease P activity
CU254_39285	COG0592	DNA-directed DNA polymerase activity
CU254_39290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CU254_39295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CU254_39300	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CU254_39305	COG0187	DNA topoisomerase II activity
CU254_39310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU254_39330	COG3173	Aminoglycoside phosphotransferase
CU254_39375	COG3973	AAA domain
CU254_39380	COG5650	phosphatidylinositol metabolic process
CU254_39400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU254_39445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU254_39465	COG3764	Sortase (surface protein transpeptidase)
CU254_39490	COG1131	(ABC) transporter
CU254_39500	COG2197	response regulator
CU254_39510	COG0604	alcohol dehydrogenase
CU254_39540	COG2815	serine threonine protein kinase
CU254_39540	COG0515	serine threonine protein kinase
CU254_39545	COG0515	serine threonine protein kinase
CU254_39550	COG0768	penicillin binding
CU254_39565	COG1716	ATPase activity
CU254_39570	COG1716	ATPase activity
CU254_39650	COG2186	Transcriptional regulator
CU254_39655	COG0747	negative chemotaxis
CU254_39670	COG0444	Belongs to the ABC transporter superfamily
CU254_39680	COG1012	belongs to the aldehyde dehydrogenase family
CU254_39690	COG0154	amidase activity
CU254_39700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CU254_39710	COG2301	Belongs to the HpcH HpaI aldolase family
CU254_39720	COG0702	epimerase
CU254_39725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CU254_39750	COG2211	Major facilitator Superfamily
CU254_39755	COG0789	Transcriptional regulator
CU254_39760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_39765	COG3209	COG3209 Rhs family protein
CU254_39795	COG2372	response to copper ion
CU254_39795	COG1276	copper resistance
CU254_39810	COG1174	glycine betaine transport
CU254_39820	COG1174	glycine betaine transport
CU254_39845	COG2226	methyltransferase
CU254_39855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU254_39880	COG0477	Major facilitator Superfamily
CU254_39890	COG4585	Histidine kinase
CU254_39895	COG2197	response regulator
CU254_39960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU254_39970	COG3275	phosphorelay sensor kinase activity
CU254_39980	COG3279	Response regulator of the LytR AlgR family
CU254_39990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_40010	COG2814	Major facilitator Superfamily
CU254_40015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_40035	COG1191	sigma factor activity
CU254_40100	COG1271	oxidase subunit
CU254_40105	COG1294	oxidase, subunit
CU254_40110	COG4988	ABC transporter
CU254_40120	COG0596	Alpha beta hydrolase
CU254_40165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CU254_40175	COG0588	phosphoglycerate mutase activity
CU254_40210	COG0754	glutathionylspermidine amidase activity
CU254_40220	COG0596	Alpha beta hydrolase
CU254_40230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU254_40235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CU254_40250	COG0579	oxidoreductase
CU254_40260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CU254_40275	COG0110	maltose O-acetyltransferase activity
CU254_40300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CU254_40305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CU254_40315	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_40355	COG0561	phosphatase activity
CU254_40360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_40375	COG0671	phosphoesterase, PA-phosphatase related
CU254_40380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CU254_40420	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_40425	COG0277	FAD linked oxidase domain protein
CU254_40435	COG1216	Glycosyl transferase, family 2
CU254_40450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CU254_40475	COG1216	Glycosyl transferase, family 2
CU254_40495	COG0596	Alpha beta hydrolase
CU254_40510	COG1063	alcohol dehydrogenase
CU254_40530	COG4249	Peptidase C14 caspase catalytic subunit p20
CU254_40565	COG4565	transcriptional regulatory protein
CU254_40570	COG3290	protein histidine kinase activity
CU254_40575	COG1116	anion transmembrane transporter activity
CU254_40595	COG2329	Antibiotic biosynthesis monooxygenase
CU254_40620	COG1522	sequence-specific DNA binding
CU254_40625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU254_40645	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_40655	COG2186	Transcriptional regulator
CU254_40675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_40685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_40690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CU254_40690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CU254_40740	COG1473	amidohydrolase
CU254_40745	COG2197	response regulator
CU254_40755	COG0842	Transport permease protein
CU254_40775	COG2326	polyphosphate kinase activity
CU254_40805	COG1404	Belongs to the peptidase S8 family
CU254_40825	COG2172	sigma factor antagonist activity
CU254_40835	COG1366	Belongs to the anti-sigma-factor antagonist family
CU254_40890	COG3559	Exporter of polyketide antibiotics
CU254_40895	COG1131	(ABC) transporter
CU254_41025	COG2175	clavaminate synthase activity
CU254_41045	COG0602	queuosine metabolic process
CU254_41070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CU254_41100	COG0483	inositol monophosphate 1-phosphatase activity
CU254_41105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CU254_41140	COG3903	Transcriptional regulator
CU254_41140	COG3629	intracellular signal transduction
CU254_41160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_41250	COG0515	serine threonine protein kinase
CU254_41265	COG1994	Peptidase M50
CU254_41300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU254_41520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_41570	COG1192	Involved in chromosome partitioning
CU254_41655	COG5001	Diguanylate cyclase
CU254_41920	COG0484	heat shock protein binding
CU254_42090	COG2814	Major facilitator Superfamily
CU254_42095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU254_42115	COG1509	lysine 2,3-aminomutase activity
CU254_42125	COG1335	isochorismatase
CU254_42135	COG2301	Belongs to the HpcH HpaI aldolase family
CU254_42140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_42145	COG2030	dehydratase
CU254_42150	COG2188	Transcriptional regulator
CU254_42155	COG2271	Major facilitator Superfamily
CU254_42175	COG3033	Beta-eliminating lyase
CU254_42250	COG0587	DNA-directed DNA polymerase activity
CU254_42395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_42715	COG0358	DNA primase activity