locus-tag class description BKN51_00095 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BKN51_00285 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BKN51_00430 ENOG4105BZM domain protein BKN51_00445 ENOG4105F95 Monooxygenase BKN51_00475 ENOG4108IG5 Transcriptional regulator BKN51_00490 ENOG4105DXM phenylacetic acid degradation protein BKN51_00495 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit BKN51_00500 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit BKN51_00505 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit BKN51_00510 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit BKN51_00515 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BKN51_00520 ENOG4105C5H ABC transporter BKN51_00535 ENOG4105CTK cobaltochelatase, cobn subunit BKN51_00545 ENOG4105VZ8 Transcriptional regulator BKN51_00555 ENOG4105CJ1 ABC, transporter BKN51_00565 ENOG41081F0 Precorrin-8x methylmutase BKN51_00575 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BKN51_00580 ENOG4108HMN Caspase domain BKN51_00585 ENOG4105EEM helicase BKN51_00590 ENOG4105J1Z Arabinosyltransferase BKN51_00610 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase BKN51_00620 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BKN51_00625 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BKN51_00655 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BKN51_00665 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BKN51_00670 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BKN51_00675 ENOG4108IXY short-chain dehydrogenase reductase BKN51_00710 ENOG4105CBC glutamate synthase BKN51_00715 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BKN51_00745 ENOG4105C32 Amino acid ABC transporter (Permease) BKN51_00750 ENOG4105C32 Amino acid ABC transporter (Permease) BKN51_00755 ENOG4105C0Z ABC transporter BKN51_00760 ENOG4108IV0 ABC, transporter BKN51_00765 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_00775 ENOG4105CQB FAD linked oxidase domain protein BKN51_00800 ENOG4108IG5 Transcriptional regulator BKN51_00830 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BKN51_00840 ENOG4105F9F transposase BKN51_00850 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) BKN51_00860 ENOG41066UZ arginase EC 3.5.3.1 BKN51_00865 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BKN51_00870 ENOG4105BZU Histidine kinase BKN51_00890 ENOG4105DCG PHP domain protein BKN51_00895 ENOG4105EG6 Saccharopine dehydrogenase BKN51_00920 ENOG4107S91 Sodium hydrogen exchanger BKN51_00925 ENOG4105DMF Dehydrogenase BKN51_00930 ENOG4105CQ7 ATP-dependent helicase BKN51_00940 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_00950 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_00985 ENOG4108UKI Enoyl-CoA hydratase BKN51_01030 ENOG4107YPT transcriptional regulator BKN51_01040 ENOG4105CHU acetyl-coa acetyltransferase BKN51_01070 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BKN51_01075 ENOG4105CAK Cell division ATP-binding protein ftsE BKN51_01085 ENOG4108PYU two-component system response regulator BKN51_01090 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BKN51_01105 ENOG4105ETE Transcriptional regulator (LacI family BKN51_01125 ENOG4105KWG Pfam:DUF1696 BKN51_01150 ENOG4105CIR epoxide hydrolase BKN51_01165 ENOG4105CPQ Dehydrogenase BKN51_01170 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BKN51_01175 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BKN51_01180 ENOG4105E2Z phosphate ABC transporter (Permease BKN51_01215 ENOG4108R85 Short chain dehydrogenase BKN51_01250 ENOG41065SU Two-component system sensor kinase BKN51_01255 ENOG4108KXV response regulator BKN51_01275 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) BKN51_01285 ENOG4105EMU Dehydrogenase BKN51_01325 ENOG4105VPX protein, conserved in bacteria BKN51_01330 ENOG4105GRZ Ycii-related protein BKN51_01375 ENOG4105E7U AraC family transcriptional regulator BKN51_01430 ENOG4105D8K carboxyl transferase BKN51_01455 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase BKN51_01475 ENOG4108S01 response regulator BKN51_01485 ENOG4107RTD sua5 ycio yrdc ywlc family protein BKN51_01510 ENOG4105E7U AraC family transcriptional regulator BKN51_01515 ENOG4108S01 response regulator BKN51_01520 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) BKN51_01540 ENOG4105DQE DNA ligase BKN51_01545 ENOG4105DQE DNA ligase BKN51_01550 ENOG4105GVJ transcriptional regulator BKN51_01560 ENOG4105C85 amino acid BKN51_01570 ENOG4105KVH Transcriptional regulator BKN51_01590 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) BKN51_01595 ENOG4105IW1 AmiS UreI transporter BKN51_01610 ENOG4108KXV response regulator BKN51_01615 ENOG41065SU Two-component system sensor kinase BKN51_01625 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_01630 ENOG4105C19 ABC transporter BKN51_01715 ENOG4105C7I Dehydrogenase BKN51_01745 ENOG4105CG3 alpha amylase, catalytic region BKN51_01755 ENOG4105D8X mechanosensitive ion channel BKN51_01770 ENOG4109057 BKN51_01780 ENOG4105MC2 DSBA oxidoreductase BKN51_01795 ENOG4108YZG isomerase BKN51_01820 ENOG4105CHP RNA polymerase BKN51_01835 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BKN51_01870 ENOG4105BZU Histidine kinase BKN51_01885 ENOG4107R7Y intracellular protease Pfpi family BKN51_01900 ENOG4105D9P serine threonine protein kinase BKN51_01925 ENOG4105F27 Major Facilitator BKN51_01930 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) BKN51_01935 ENOG4105CD3 dihydroorotase BKN51_01950 ENOG4105EDW glycosyl transferase, family 39 BKN51_01960 ENOG4105EDW glycosyl transferase, family 39 BKN51_01965 ENOG4105BZU Histidine kinase BKN51_01970 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BKN51_01975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BKN51_01985 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BKN51_02020 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BKN51_02035 ENOG4107TB5 TRANSCRIPTIONal BKN51_02065 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BKN51_02080 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BKN51_02110 ENOG4105KVH Transcriptional regulator BKN51_02115 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BKN51_02135 ENOG4105CJ1 ABC, transporter BKN51_02145 ENOG4105HAC ABC-2 type transporter BKN51_02155 ENOG4105C03 ribonuclease BKN51_02160 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BKN51_02165 ENOG4105K46 50S ribosomal protein l27 BKN51_02170 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BKN51_02175 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BKN51_02200 ENOG4105C75 arginyL-tRNA synthetase BKN51_02205 ENOG4105CSH Transporter BKN51_02210 ENOG4105C9U ATP-dependent DNA helicase RecQ BKN51_02215 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BKN51_02220 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BKN51_02225 ENOG4105CVJ phosphoglycerate mutase BKN51_02235 ENOG4105EPR degv family BKN51_02245 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BKN51_02260 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BKN51_02275 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_02295 ENOG4105E2D ec 3.2.1.52 BKN51_02300 ENOG4105EA8 2-Nitropropane dioxygenase BKN51_02305 ENOG4105CUB amino acid BKN51_02315 ENOG4105CB2 alcohol dehydrogenase BKN51_02330 ENOG41067XF inhibitor BKN51_02335 ENOG4108IPT Naphthoate synthase BKN51_02360 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BKN51_02405 ENOG4105CKK Glycosyl transferase, family 2 BKN51_02480 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BKN51_02490 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BKN51_02495 ENOG4108PYU two-component system response regulator BKN51_02500 ENOG4105EB3 Histidine kinase BKN51_02520 ENOG4105C26 Dehydrogenase BKN51_02525 ENOG4107S5I aldo keto reductase BKN51_02530 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BKN51_02535 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BKN51_02545 ENOG4107YU2 histidine triad (hIT) protein BKN51_02555 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BKN51_02570 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BKN51_02605 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BKN51_02610 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BKN51_02620 ENOG4108PJD permease BKN51_02655 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BKN51_02660 ENOG4108M15 ABC transporter BKN51_02670 ENOG4105BZU Histidine kinase BKN51_02675 ENOG4108S01 response regulator BKN51_02685 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BKN51_02700 ENOG4105C26 Dehydrogenase BKN51_02705 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BKN51_02710 ENOG4108KPJ rna polymerase sigma factor BKN51_02725 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BKN51_02755 ENOG4105ECQ AraC Family Transcriptional Regulator BKN51_02760 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BKN51_02795 ENOG4105CUB amino acid BKN51_02810 ENOG4106F1P AAA ATPase, central domain protein BKN51_02825 ENOG4105EC2 ftsk spoIIIe BKN51_02920 ENOG4108R5S membrane BKN51_02960 ENOG4105F9F transposase BKN51_02980 ENOG4105G9B Transcriptional regulator BKN51_02985 ENOG4105CT3 Monooxygenase BKN51_02990 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BKN51_03010 ENOG4105EU0 Major facilitator Superfamily BKN51_03015 ENOG4105R1U AraC Family Transcriptional Regulator BKN51_03045 ENOG4105D8V Glucose sorbosone dehydrogenase BKN51_03050 ENOG4105BZU Histidine kinase BKN51_03060 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_03075 ENOG4105CHR reductase BKN51_03085 ENOG4105CDH Citrulline--aspartate ligase BKN51_03150 ENOG41062D9 Histidine kinase BKN51_03200 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BKN51_03225 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN51_03260 ENOG4105IDI abc transporter atp-binding protein BKN51_03315 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase BKN51_03325 ENOG41073TP transcriptional regulator BKN51_03345 ENOG4105U5Y Transcriptional regulator BKN51_03360 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BKN51_03390 ENOG4105ECY inositol monophosphatase BKN51_03395 ENOG4107QNK )-transporter BKN51_03400 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BKN51_03435 ENOG4105CHR reductase BKN51_03450 ENOG4108IND Tetr family transcriptional regulator BKN51_03470 ENOG4105D74 hydrolase BKN51_03520 ENOG4105KRM Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BKN51_03540 ENOG4107TB5 TRANSCRIPTIONal BKN51_03555 ENOG4105C1G acyl-Coa dehydrogenase BKN51_03560 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) BKN51_03570 ENOG4106YT9 Enoyl-CoA hydratase BKN51_03575 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BKN51_03580 ENOG4107RSM transcriptional regulator BKN51_03585 ENOG4105BZU Histidine kinase BKN51_03590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN51_03610 ENOG4105KVH Transcriptional regulator BKN51_03615 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_03620 ENOG4105BZU Histidine kinase BKN51_03635 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BKN51_03670 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) BKN51_03680 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BKN51_03690 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BKN51_03700 ENOG4105EAB amino acid AbC transporter BKN51_03705 ENOG4105CDA abc transporter atp-binding protein BKN51_03720 ENOG4105SFS phosphoesterase RecJ domain protein BKN51_03735 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BKN51_03755 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BKN51_03760 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BKN51_03765 ENOG4105C1V Peptidase, M16 BKN51_03770 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BKN51_03790 ENOG4105T0Z Conserved Protein BKN51_03820 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BKN51_03825 ENOG4105CN5 Metallo-Beta-Lactamase BKN51_03840 ENOG4105C85 amino acid BKN51_03850 ENOG4107AQZ Membrane BKN51_03880 ENOG4107QZI cell division protein FtsK BKN51_03890 ENOG4108JSS Haloalkane dehalogenase BKN51_03905 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) BKN51_03915 ENOG4105CEV competence damage-inducible protein BKN51_03920 ENOG4105WBV Transcriptional regulator BKN51_03945 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_03950 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BKN51_03960 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BKN51_03965 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) BKN51_03970 ENOG4107SKI cobyrinic Acid a,c-diamide synthase BKN51_03975 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BKN51_03980 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BKN51_04000 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BKN51_04025 ENOG4108V6E Cell division protein mraZ BKN51_04030 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BKN51_04040 ENOG4105CJN penicillin-binding protein BKN51_04055 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BKN51_04060 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BKN51_04075 ENOG4105DFU Cell wall formation (By similarity) BKN51_04080 ENOG4105ME9 cell division protein FtsQ BKN51_04120 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BKN51_04170 ENOG4108UZ3 Transporter BKN51_04205 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BKN51_04210 ENOG4107QRT dEAD DEAH box helicase BKN51_04215 ENOG4105CFG Acts as a chaperone (By similarity) BKN51_04225 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BKN51_04230 ENOG4105KC9 Modulates RecA activity (By similarity) BKN51_04250 ENOG4108UHU Aldolase BKN51_04255 ENOG4105C01 Dihydroxy-acid dehydratase BKN51_04270 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BKN51_04280 ENOG4105F9F transposase BKN51_04300 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BKN51_04305 ENOG4105DRP amino acid AbC transporter BKN51_04310 ENOG4108Q1T ABC transporter BKN51_04315 ENOG4107UBR Extracellular solute-binding protein family 3 BKN51_04320 ENOG4105CDA abc transporter atp-binding protein BKN51_04325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN51_04330 ENOG41062D9 Histidine kinase BKN51_04340 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BKN51_04350 ENOG4105C99 atpase involved in dna repair BKN51_04360 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BKN51_04365 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BKN51_04380 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BKN51_04390 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BKN51_04400 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BKN51_04405 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BKN51_04440 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BKN51_04445 ENOG4105KPY Small multidrug resistance protein BKN51_04470 ENOG4105BZP glycoside hydrolase 15-related BKN51_04485 ENOG4105DSF transport protein BKN51_04500 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BKN51_04520 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BKN51_04530 ENOG4105KHC sulfurtransferase BKN51_04535 ENOG4105DGU Histone deacetylase BKN51_04555 ENOG4105J5T Amp-dependent synthetase and ligase BKN51_04560 ENOG4108KC2 acyl-Coa dehydrogenase BKN51_04565 ENOG4105X7H acyl-CoA dehydrogenase BKN51_04575 ENOG4105CHR reductase BKN51_04640 ENOG4105XT2 Transcriptional regulator BKN51_04650 ENOG41061H0 Monooxygenase BKN51_04685 ENOG4105DKQ ROK family BKN51_04695 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) BKN51_04720 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BKN51_04730 ENOG4105CI2 imidazolone-5-propionate hydrolase BKN51_04765 ENOG4105C29 acyl-CoA thioesterase BKN51_04785 ENOG4107SM8 Adenylate Guanylate cyclase BKN51_04790 ENOG4105C26 Dehydrogenase BKN51_04810 ENOG4105C1G acyl-Coa dehydrogenase BKN51_04815 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BKN51_04825 ENOG4105E39 Enoyl-CoA hydratase BKN51_04845 ENOG4105VCH membrane BKN51_04855 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BKN51_04860 ENOG4107QN1 sodium solute BKN51_04875 ENOG4105GWZ Roadblock lc7 family protein BKN51_04890 ENOG4105NAE bifunctional deaminase-reductase domain protein BKN51_04905 ENOG4105D5P Methylmalonyl-coA mutase BKN51_04910 ENOG4105DYW oxidoreductase BKN51_04920 ENOG4108SGK Tetr family transcriptional regulator BKN51_04925 ENOG4105D2B acyl-CoA dehydrogenase BKN51_04930 ENOG4105C0D helicase BKN51_04950 ENOG4108RK3 acyl-Coa dehydrogenase BKN51_04955 ENOG4105X7H acyl-CoA dehydrogenase BKN51_05010 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein BKN51_05020 ENOG4108KC1 acyl-Coa dehydrogenase BKN51_05025 ENOG41088PD hydrolase BKN51_05030 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase BKN51_05035 ENOG4105MXW flavin reductase domain protein, FMN-binding BKN51_05040 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_05060 ENOG4105F9F transposase BKN51_05085 ENOG4105C1G acyl-Coa dehydrogenase BKN51_05090 ENOG4105D2B acyl-CoA dehydrogenase BKN51_05095 ENOG4105CC9 acyl-Coa dehydrogenase BKN51_05105 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_05110 ENOG4105CC9 acyl-Coa dehydrogenase BKN51_05115 ENOG4105CHR reductase BKN51_05120 ENOG4108RZE Tetr family transcriptional regulator BKN51_05125 ENOG4105F2C Acetyl-CoA acetyltransferase BKN51_05140 ENOG4107QN2 dihydrolipoyl dehydrogenase BKN51_05180 ENOG4108UW5 maltose o-acetyltransferase BKN51_05195 ENOG4108VQT Alpha beta hydrolase fold protein BKN51_05200 ENOG4105EA8 2-Nitropropane dioxygenase BKN51_05215 ENOG4105E39 Enoyl-CoA hydratase BKN51_05220 ENOG4105CHR reductase BKN51_05225 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BKN51_05245 ENOG4105F2C Acetyl-CoA acetyltransferase BKN51_05250 ENOG4106A3M Cytochrome p-450 BKN51_05260 ENOG4107H3J ribonuclease BKN51_05285 ENOG4105E39 Enoyl-CoA hydratase BKN51_05305 ENOG4105FDP GntR family transcriptional regulator BKN51_05310 ENOG4105MWK D-amino acid dehydrogenase, small subunit BKN51_05315 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BKN51_05350 ENOG4107GFK fumarate BKN51_05365 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BKN51_05370 ENOG4105CH2 amidohydrolase BKN51_05380 ENOG4105D7K pfkb domain protein BKN51_05385 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) BKN51_05425 ENOG4105DFW ABC transporter BKN51_05430 ENOG4105C2J ABC transporter BKN51_05435 ENOG4108HWW ABC transporter BKN51_05445 ENOG4108IG5 Transcriptional regulator BKN51_05450 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) BKN51_05460 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BKN51_05470 ENOG4105CUB amino acid BKN51_05475 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_05485 ENOG4105IIP Membrane BKN51_05500 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BKN51_05545 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BKN51_05575 ENOG4107VEG TrkA-N domain protein BKN51_05580 ENOG4105C0X amino acid BKN51_05585 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BKN51_05605 ENOG4105BZU Histidine kinase BKN51_05610 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_05625 ENOG4105C26 Dehydrogenase BKN51_05630 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BKN51_05650 ENOG4105E1F short-chain dehydrogenase reductase BKN51_05660 ENOG4105C26 Dehydrogenase BKN51_05675 ENOG4105CK7 Sodium proline symporter BKN51_05685 ENOG4105F44 Two component transcriptional regulator, winged helix family BKN51_05690 ENOG4106F60 Histidine kinase BKN51_05695 ENOG4105CV8 reductase BKN51_05715 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN51_05720 ENOG4105CHU acetyl-coa acetyltransferase BKN51_05750 ENOG4105CUB amino acid BKN51_05765 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_05775 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BKN51_05785 ENOG4107JTW chlorite dismutase BKN51_05790 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BKN51_05800 ENOG4105E18 UPF0276 protein BKN51_05820 ENOG4105E0X reductase BKN51_05840 ENOG4105D9U N-acetyltransferase BKN51_05845 ENOG4105DQE DNA ligase BKN51_05850 ENOG41080V3 Major Facilitator superfamily BKN51_05870 ENOG4105DEN Luciferase family BKN51_05875 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BKN51_05880 ENOG4108K8K Transcriptional regulator BKN51_05885 ENOG4105C26 Dehydrogenase BKN51_05895 ENOG41080RH Thioredoxin BKN51_05945 ENOG4105EMN RNA polymerase sigma factor BKN51_05955 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BKN51_05970 ENOG4105C8Y Acetylornithine aminotransferase BKN51_05975 ENOG4105CSR polyphosphate kinase 2 BKN51_05990 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase BKN51_06000 ENOG41083TI Protein CrcB homolog BKN51_06005 ENOG41083YR Protein CrcB homolog BKN51_06030 ENOG4105C9M aspartyl-trna synthetase BKN51_06060 ENOG4108JQ9 ABC transporter BKN51_06075 ENOG4108I5U Uridine phosphorylase BKN51_06085 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BKN51_06090 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) BKN51_06095 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BKN51_06100 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BKN51_06120 ENOG4105HSS phospholipase C BKN51_06135 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BKN51_06150 ENOG4105E2X shikimate dehydrogenase BKN51_06155 ENOG4105RHY Pfam:UPF0157 BKN51_06165 ENOG4105F9F transposase BKN51_06175 ENOG41067SE Tetr family transcriptional regulator BKN51_06205 ENOG410849S phosphocarrier protein (HPr) BKN51_06210 ENOG4105CI1 PTS System BKN51_06215 ENOG4105FDP GntR family transcriptional regulator BKN51_06220 ENOG4105CI1 PTS System BKN51_06255 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BKN51_06260 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BKN51_06270 ENOG4105D49 3-dehydroquinate synthase BKN51_06275 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BKN51_06280 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BKN51_06295 ENOG4105DC7 peptidase M24 BKN51_06300 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BKN51_06305 ENOG410803B Involved in the transcription termination process (By similarity) BKN51_06315 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BKN51_06320 ENOG4105CXT aspartate transcarbamylase BKN51_06335 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BKN51_06345 ENOG4105SKN orotidine 5''-phosphate decarboxylase BKN51_06355 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BKN51_06360 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BKN51_06370 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BKN51_06375 ENOG4107RSZ Primosomal protein n' BKN51_06380 ENOG4105NGS secreted protein BKN51_06385 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BKN51_06390 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BKN51_06415 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_06420 ENOG4105BZU Histidine kinase BKN51_06435 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BKN51_06440 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BKN51_06460 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BKN51_06465 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BKN51_06475 ENOG4105CIE May be required for sporulation (By similarity) BKN51_06495 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BKN51_06575 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BKN51_06580 ENOG4105BZA Phosphoglycerate kinase BKN51_06585 ENOG4105CP7 Triose-phosphate isomerase BKN51_06595 ENOG4105Q70 BKN51_06605 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) BKN51_06625 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BKN51_06635 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BKN51_06660 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BKN51_06680 ENOG4107VFP cytochrome oxidase assembly BKN51_06695 ENOG4107JC6 Membrane BKN51_06715 ENOG4105C3K feS assembly ATPase SufC BKN51_06725 ENOG4108UNV SUF system FeS assembly protein, NifU family BKN51_06730 ENOG4105VG1 fes assembly suf system protein BKN51_06735 ENOG4105KK4 UPF0060 membrane protein BKN51_06760 ENOG4105BZU Histidine kinase BKN51_06765 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_06780 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BKN51_06800 ENOG4108KEZ Dehydrogenase BKN51_06810 ENOG4105BZU Histidine kinase BKN51_06820 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BKN51_06835 ENOG4105C5H ABC transporter BKN51_06850 ENOG4105BZ1 (ABC) transporter BKN51_06860 ENOG4108SU4 UPF0309 protein BKN51_06870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BKN51_06875 ENOG4108KGH TRANSCRIPTIONal BKN51_06890 ENOG4105BZU Histidine kinase BKN51_06900 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BKN51_06905 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BKN51_06910 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BKN51_06920 ENOG41060WC Enoyl-CoA hydratase BKN51_06940 ENOG4105CIS alcohol dehydrogenase BKN51_06965 ENOG4105C1G acyl-Coa dehydrogenase BKN51_06970 ENOG4107QX3 carboxylase BKN51_06985 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BKN51_06990 ENOG4108IG5 Transcriptional regulator BKN51_07015 ENOG4106UDK Cellulose-binding, family II BKN51_07020 ENOG4105BZU Histidine kinase BKN51_07035 ENOG4105CSH Transporter BKN51_07040 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BKN51_07045 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BKN51_07095 ENOG4105C57 major facilitator superfamily BKN51_07115 ENOG4108JA1 polyketide synthase BKN51_07130 ENOG4107EEY synthase BKN51_07145 ENOG4107EEY synthase BKN51_07155 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN51_07165 ENOG4105C1G acyl-Coa dehydrogenase BKN51_07190 ENOG4108X79 transcriptional regulator BKN51_07210 ENOG4105YA8 Transcriptional regulator BKN51_07220 ENOG4105D2B acyl-CoA dehydrogenase BKN51_07225 ENOG4105D2B acyl-CoA dehydrogenase BKN51_07230 ENOG4105C1G acyl-Coa dehydrogenase BKN51_07255 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BKN51_07260 ENOG4105DHP deoxycytidine triphosphate deaminase BKN51_07280 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BKN51_07295 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BKN51_07315 ENOG4107QHQ amino acid BKN51_07320 ENOG4105DKQ ROK family BKN51_07385 ENOG4105C34 Pseudouridine synthase BKN51_07400 ENOG4105K56 Transcriptional regulator BKN51_07430 ENOG4105DEN Luciferase family BKN51_07435 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_07500 ENOG410870F Cyclic nucleotide-binding protein BKN51_07515 ENOG4105F27 Major Facilitator BKN51_07520 ENOG4107ZR7 Membrane BKN51_07540 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BKN51_07560 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BKN51_07575 ENOG4105BZU Histidine kinase BKN51_07600 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BKN51_07605 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BKN51_07620 ENOG41065SU Two-component system sensor kinase BKN51_07625 ENOG4108KXV response regulator BKN51_07635 ENOG4105BZU Histidine kinase BKN51_07650 ENOG4105FDR Membrane BKN51_07670 ENOG4108IG5 Transcriptional regulator BKN51_07690 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BKN51_07700 ENOG4105KF0 sporulation and cell division protein, SsgA BKN51_07710 ENOG4107YPT transcriptional regulator BKN51_07720 ENOG4105DYW oxidoreductase BKN51_07725 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein BKN51_07735 ENOG4107258 Transcriptional regulator BKN51_07740 ENOG4105D9P serine threonine protein kinase BKN51_07750 ENOG4106A3M Cytochrome p-450 BKN51_07760 ENOG41068WN BKN51_07765 ENOG4105KVH Transcriptional regulator BKN51_07770 ENOG4105M4P Tetr family transcriptional regulator BKN51_07775 ENOG4105CHR reductase BKN51_07810 ENOG4105F9F transposase BKN51_07830 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BKN51_07855 ENOG4105CKQ methane phenol toluene hydroxylase BKN51_07880 ENOG41070H7 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BKN51_07885 ENOG4105VMP Transcriptional regulator BKN51_07930 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BKN51_07955 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BKN51_07965 ENOG4108NBA ATP-dependent carboxylate-amine ligase (By similarity) BKN51_07970 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BKN51_07975 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BKN51_08085 ENOG4105D3W isochorismatase BKN51_08105 ENOG4105ECY inositol monophosphatase BKN51_08120 ENOG4105F6J Alpha beta hydrolase fold BKN51_08150 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein BKN51_08170 ENOG4108YIQ Alpha beta hydrolase BKN51_08200 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_08235 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_08240 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_08250 ENOG4105DBV ornithine carbamoyltransferase BKN51_08260 ENOG4105C7B Threonine dehydratase BKN51_08305 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BKN51_08315 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BKN51_08330 ENOG4107EEY synthase BKN51_08385 ENOG4108UXE Protein tyrosine phosphatase BKN51_08400 ENOG4108V9Q carbonic anhydrase BKN51_08415 ENOG4105PFC Transcriptional regulator BKN51_08425 ENOG4108IG5 Transcriptional regulator BKN51_08430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_08440 ENOG4105DEF Extracellular solute-binding protein, family 5 BKN51_08445 ENOG4108JQ6 ABC transporter BKN51_08450 ENOG4105CPC Aldo Keto reductase BKN51_08475 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase BKN51_08485 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BKN51_08510 ENOG4105CAQ asparagine synthetase BKN51_08535 ENOG4105DBV ornithine carbamoyltransferase BKN51_08540 ENOG410829K Lysine exporter protein (Lyse ygga) BKN51_08550 ENOG4105KVH Transcriptional regulator BKN51_08555 ENOG4105ECR NmrA family BKN51_08560 ENOG4105EX0 alpha-galactosidase BKN51_08575 ENOG41067TZ transcriptional regulator, MarR family BKN51_08580 ENOG4105EFZ amidohydrolase BKN51_08590 ENOG4105D38 putrescine abc transporter BKN51_08595 ENOG4105F38 ABC transporter, permease BKN51_08605 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BKN51_08610 ENOG4105C26 Dehydrogenase BKN51_08620 ENOG4105EA8 2-Nitropropane dioxygenase BKN51_08625 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_08630 ENOG4108UKI Enoyl-CoA hydratase BKN51_08640 ENOG4105E39 Enoyl-CoA hydratase BKN51_08645 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) BKN51_08655 ENOG4105CSP Major Facilitator Superfamily BKN51_08660 ENOG4105C2W permease BKN51_08670 ENOG4105DQ5 transport system permease protein BKN51_08675 ENOG4105TVJ transport system, permease BKN51_08755 ENOG4105KVH Transcriptional regulator BKN51_08770 ENOG4105C2C drug resistance transporter, Bcr CflA BKN51_08785 ENOG4108KXV response regulator BKN51_08790 ENOG41065SU Two-component system sensor kinase BKN51_08800 ENOG4105EXC Acyl-transferase BKN51_08805 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_08900 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_08910 ENOG4108HMN Caspase domain BKN51_08970 ENOG4105DYW oxidoreductase BKN51_08985 ENOG4105C57 major facilitator superfamily BKN51_08995 ENOG4105D74 hydrolase BKN51_09010 ENOG4105C0W non-ribosomal peptide synthetase BKN51_09060 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_09065 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_09075 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_09115 ENOG4105Y3U Transglycosylase-associated protein BKN51_09145 ENOG4107RGD Major Facilitator superfamily BKN51_09160 ENOG4105E7W lamb ycsf family protein BKN51_09165 ENOG4105C8Y Acetylornithine aminotransferase BKN51_09185 ENOG4108XIC integral membrane protein BKN51_09190 ENOG4105KV4 Transcriptional regulator BKN51_09220 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_09235 ENOG41087PP glycosyltransferase MGT family BKN51_09260 ENOG4107EEY synthase BKN51_09290 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_09295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN51_09305 ENOG4105C1G acyl-Coa dehydrogenase BKN51_09320 ENOG4108JA1 polyketide synthase BKN51_09325 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_09335 ENOG4107QK4 glycoside hydrolase, family 3 domain protein BKN51_09345 ENOG4106A3M Cytochrome p-450 BKN51_09365 ENOG4105F9F transposase BKN51_09370 ENOG4107EEY synthase BKN51_09410 ENOG4106A3M Cytochrome p-450 BKN51_09465 ENOG4108JGH Tetr family transcriptional regulator BKN51_09470 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BKN51_09515 ENOG4105F0K SARP family transcriptional regulator BKN51_09555 ENOG4105KF0 sporulation and cell division protein, SsgA BKN51_09565 ENOG4105D3Q Sugar transferase BKN51_09570 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) BKN51_09575 ENOG4105C22 threonyL-tRNA synthetase BKN51_09595 ENOG4108VTU Cdp-alcohol phosphatidyltransferase BKN51_09600 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase BKN51_09605 ENOG4105E2K Glycosyl transferase (Group 1 BKN51_09615 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family BKN51_09625 ENOG4105DNP FAD linked oxidase domain protein BKN51_09630 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BKN51_09650 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BKN51_09655 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_09670 ENOG4107SM8 Adenylate Guanylate cyclase BKN51_09680 ENOG4106T9R serine protease BKN51_09700 ENOG4108RZE Tetr family transcriptional regulator BKN51_09725 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BKN51_09730 ENOG4105CDY transcriptional regulatory protein BKN51_09745 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BKN51_09750 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BKN51_09755 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BKN51_09760 ENOG4105ZCJ preprotein translocase subunit yajC BKN51_09770 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BKN51_09775 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BKN51_09780 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BKN51_09785 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase BKN51_09800 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) BKN51_09805 ENOG4105C5X domain protein BKN51_09880 ENOG4105GWZ Roadblock lc7 family protein BKN51_09900 ENOG4105FDF Could be involved in DNA repair (By similarity) BKN51_09910 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BKN51_09935 ENOG4105N14 lysine exporter protein LysE YggA BKN51_09955 ENOG4105CIR epoxide hydrolase BKN51_09965 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BKN51_09970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BKN51_09975 ENOG41060W2 glyoxylate carboligase BKN51_09995 ENOG4107SQI penicillin amidase BKN51_10005 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BKN51_10015 ENOG4105DWY Agmatine deiminase BKN51_10035 ENOG4105DQE DNA ligase BKN51_10040 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BKN51_10065 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BKN51_10105 ENOG4105BZU Histidine kinase BKN51_10140 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) BKN51_10185 ENOG4105EUJ GTP cyclohydrolase i BKN51_10195 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BKN51_10200 ENOG4105CHR reductase BKN51_10210 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BKN51_10215 ENOG4108R86 Transcriptional regulator BKN51_10220 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BKN51_10245 ENOG4105DRS transport system, permease BKN51_10260 ENOG4105ETE Transcriptional regulator (LacI family BKN51_10265 ENOG4105ETE Transcriptional regulator (LacI family BKN51_10270 ENOG4105EF1 ribulokinase BKN51_10280 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BKN51_10285 ENOG4105DFW ABC transporter BKN51_10290 ENOG4105C2J ABC transporter BKN51_10295 ENOG4107RNG ABC transporter BKN51_10300 ENOG4105CNT hydrolase family 2 BKN51_10335 ENOG4108IV0 ABC, transporter BKN51_10340 ENOG4105C0Z ABC transporter BKN51_10365 ENOG41063TF transcriptional regulator (AraC BKN51_10380 ENOG4105KVH Transcriptional regulator BKN51_10395 ENOG4105DEN Luciferase family BKN51_10410 ENOG4105C01 Dihydroxy-acid dehydratase BKN51_10445 ENOG4105BZU Histidine kinase BKN51_10450 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_10475 ENOG4105WN5 stage II sporulation protein BKN51_10500 ENOG4108KXM LysR family Transcriptional regulator BKN51_10535 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BKN51_10540 ENOG4105CTU Proline racemase BKN51_10550 ENOG4105CPN adenine deaminase BKN51_10560 ENOG41079KZ Major Facilitator Superfamily BKN51_10590 ENOG4106T9R serine protease BKN51_10615 ENOG410880H cysteine synthase BKN51_10655 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN51_10660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_10670 ENOG4108JQ7 (ABC) transporter BKN51_10680 ENOG4107VHA regulatoR BKN51_10690 ENOG4105DTQ mandelate racemase muconate lactonizing BKN51_10795 ENOG4105E39 Enoyl-CoA hydratase BKN51_10805 ENOG4105C5H ABC transporter BKN51_10840 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BKN51_10845 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BKN51_10855 ENOG4105F9F transposase BKN51_10860 ENOG4108HUF Transporter BKN51_10865 ENOG4105BZ1 (ABC) transporter BKN51_10870 ENOG4105BZ1 (ABC) transporter BKN51_10875 ENOG4105DQ5 transport system permease protein BKN51_10880 ENOG4105TVJ transport system, permease BKN51_10895 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BKN51_10945 ENOG4105DYW oxidoreductase BKN51_10950 ENOG4107R72 Ceramidase BKN51_10955 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BKN51_10975 ENOG4105NPE arsR family transcriptional regulator BKN51_10995 ENOG4105CKI cobalamin synthesis protein BKN51_11000 ENOG4108BT0 50S ribosomal protein L32 BKN51_11005 ENOG4105NRA 50s ribosomal protein l31 type b BKN51_11015 ENOG4105KDC 50s ribosomal protein l28 BKN51_11020 ENOG4105W0E 50S ribosomal protein L33 BKN51_11025 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BKN51_11030 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BKN51_11040 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BKN51_11055 ENOG4105E39 Enoyl-CoA hydratase BKN51_11060 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BKN51_11075 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BKN51_11125 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BKN51_11130 ENOG4108UW8 fha domain-containing protein BKN51_11155 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BKN51_11170 ENOG4105CV8 reductase BKN51_11225 ENOG4105D82 Glutamate dehydrogenase BKN51_11230 ENOG4105DUM transcriptional regulator, lysR family BKN51_11240 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process BKN51_11245 ENOG4108V75 Glutamine amidotransferase BKN51_11250 ENOG41067HS methyltransferase BKN51_11275 ENOG4105C57 major facilitator superfamily BKN51_11280 ENOG41064T2 transcriptional regulator, lysR family BKN51_11295 ENOG4107QM5 aconitate hydratase BKN51_11300 ENOG4105ZXU NLP P60 protein BKN51_11305 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BKN51_11315 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BKN51_11325 ENOG4107QVM von Willebrand factor, type A BKN51_11330 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BKN51_11335 ENOG4105DGI Alkaline phosphatase BKN51_11365 ENOG4105CSH Transporter BKN51_11375 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BKN51_11395 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BKN51_11400 ENOG4105W1N transcriptional regulator BKN51_11405 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BKN51_11420 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_11425 ENOG4105BZU Histidine kinase BKN51_11435 ENOG4107KWJ von Willebrand factor, type A BKN51_11445 ENOG4107TXC Transcriptional regulator BKN51_11450 ENOG4105C8N cysteinyl-tRNA synthetase BKN51_11460 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BKN51_11470 ENOG4107Y80 Major Facilitator superfamily BKN51_11500 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase BKN51_11505 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BKN51_11510 ENOG4107QJE Chromosome Partitioning Protein BKN51_11545 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) BKN51_11575 ENOG4108Z4K mutator MutT protein BKN51_11580 ENOG4105E5F proteasome BKN51_11585 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) BKN51_11590 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) BKN51_11595 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) BKN51_11615 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) BKN51_11625 ENOG4105WAB arsR family transcriptional regulator BKN51_11645 ENOG4105EE1 crotonyl-CoA reductase BKN51_11650 ENOG4105KVH Transcriptional regulator BKN51_11660 ENOG4107TMB Transcriptional regulator BKN51_11670 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BKN51_11680 ENOG4105CBD Diacylglycerol kinase BKN51_11715 ENOG4105EUB pirin domain protein BKN51_11745 ENOG4105J0Q Transcriptional regulator BKN51_11765 ENOG4105CPC Aldo Keto reductase BKN51_11775 ENOG4107SCK Monooxygenase BKN51_11790 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BKN51_11795 ENOG4108ME1 Peptidase M55 D-aminopeptidase BKN51_11825 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) BKN51_11830 ENOG4107SMB hydrolase Family 5 BKN51_11835 ENOG4108KPJ rna polymerase sigma factor BKN51_11850 ENOG4105CHU acetyl-coa acetyltransferase BKN51_11855 ENOG4107YPT transcriptional regulator BKN51_11895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN51_11910 ENOG41090CE integral membrane protein BKN51_11925 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BKN51_11970 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BKN51_11975 ENOG4105CSH Transporter BKN51_11985 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_12005 ENOG41082BM Transcriptional regulator, arsr family BKN51_12010 ENOG4105XEA Tetr family transcriptional regulator BKN51_12035 ENOG4105FB2 class II Aldolase BKN51_12040 ENOG4105G63 Type III effector Hrp-dependent BKN51_12050 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BKN51_12055 ENOG4108JQ1 Dehydrogenase BKN51_12070 ENOG4107FW0 short-chain dehydrogenase reductase BKN51_12080 ENOG4105CIR epoxide hydrolase BKN51_12100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BKN51_12110 ENOG4107Y2X deaminase BKN51_12135 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BKN51_12150 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit BKN51_12155 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding BKN51_12160 ENOG4105C7W Xanthine dehydrogenase BKN51_12170 ENOG4105EBR Carboxylesterase BKN51_12200 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_12205 ENOG4105ENE Histidine kinase BKN51_12220 ENOG4105EG6 Saccharopine dehydrogenase BKN51_12240 ENOG4105C57 major facilitator superfamily BKN51_12330 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_12335 ENOG4105BZU Histidine kinase BKN51_12350 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BKN51_12365 ENOG4108TKH Nitroreductase BKN51_12410 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BKN51_12420 ENOG4105CI2 imidazolone-5-propionate hydrolase BKN51_12430 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BKN51_12450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BKN51_12460 ENOG4107W53 thymidine kinase BKN51_12485 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BKN51_12495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_12500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_12505 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BKN51_12520 ENOG4108MMM RNA Polymerase BKN51_12530 ENOG4108SGK Tetr family transcriptional regulator BKN51_12535 ENOG4105CSU acyl-Coa dehydrogenase BKN51_12545 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase BKN51_12565 ENOG4105C0D helicase BKN51_12615 ENOG4107S9F NmrA family BKN51_12630 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr BKN51_12635 ENOG4105DDN Pentapeptide repeat-containing protein BKN51_12640 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_12645 ENOG4108VQR secreted hydrolase BKN51_12685 ENOG4107URF beta-phospho-glucomutase BKN51_12865 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BKN51_12875 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_12900 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BKN51_12915 ENOG4107S9F NmrA family BKN51_12930 ENOG4105J7D transcriptional regulator BKN51_12935 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BKN51_12950 ENOG4105C7K acetolactate synthase BKN51_12985 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BKN51_13060 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_13095 ENOG4106FTQ Taurine ABC transporter, periplasmic BKN51_13100 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BKN51_13135 ENOG4106NMR serine protease BKN51_13185 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BKN51_13195 ENOG4108PA7 Methyltransferase BKN51_13200 ENOG4105ESN nucleotide-binding protein BKN51_13200 ENOG4105ESN nucleotide-binding protein BKN51_13205 ENOG4105ESN nucleotide-binding protein BKN51_13240 ENOG4105U5Y Transcriptional regulator BKN51_13250 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BKN51_13270 ENOG4108KTG Membrane protein, drug metabolite transporter BKN51_13280 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BKN51_13300 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BKN51_13305 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BKN51_13315 ENOG4105CWX Alpha-1,2-mannosidase BKN51_13320 ENOG4105C57 major facilitator superfamily BKN51_13330 ENOG4108KPJ rna polymerase sigma factor BKN51_13360 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BKN51_13370 ENOG4108Z6Z Transcriptional regulator BKN51_13390 ENOG4105D06 uba thif-type nad fad binding protein BKN51_13430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BKN51_13435 ENOG4105C3J Cysteine desulfurase BKN51_13440 ENOG4105DGW oligopeptidase A BKN51_13450 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BKN51_13455 ENOG4105DYW oxidoreductase BKN51_13460 ENOG4105CPC Aldo Keto reductase BKN51_13490 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BKN51_13495 ENOG4105EDW glycosyl transferase, family 39 BKN51_13610 ENOG4105C26 Dehydrogenase BKN51_13620 ENOG4105EGE secreted protein BKN51_13635 ENOG410908R Methenyltetrahydrofolate cyclohydrolase BKN51_13640 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BKN51_13715 ENOG4105CHR reductase BKN51_13760 ENOG4105C93 Xylose Isomerase BKN51_13765 ENOG4105DKQ ROK family BKN51_13795 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 BKN51_13830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BKN51_13860 ENOG41062B0 ABC transporter, permease BKN51_13865 ENOG4107R9N ABC transporter BKN51_13870 ENOG4105C2J ABC transporter BKN51_13875 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BKN51_13880 ENOG4105ETE Transcriptional regulator (LacI family BKN51_13885 ENOG4105BZU Histidine kinase BKN51_13890 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_13915 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_13920 ENOG4105BZU Histidine kinase BKN51_13955 ENOG4105DPX Hydrogenase, large subunit BKN51_13980 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BKN51_13990 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BKN51_14015 ENOG4105C45 hydrogenase expression formation protein (HypE) BKN51_14020 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BKN51_14075 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_14090 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_14110 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BKN51_14145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN51_14150 ENOG4107QSI ABC, transporter BKN51_14170 ENOG4105CXY transporter BKN51_14180 ENOG4105DTQ mandelate racemase muconate lactonizing BKN51_14195 ENOG4105CD3 dihydroorotase BKN51_14205 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BKN51_14240 ENOG4105BZ1 (ABC) transporter BKN51_14270 ENOG4105KVH Transcriptional regulator BKN51_14290 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_14295 ENOG4105EXC Acyl-transferase BKN51_14300 ENOG4105GR3 Histidine kinase BKN51_14305 ENOG4105ETX regulatoR BKN51_14315 ENOG4105CGD Nad-dependent epimerase dehydratase BKN51_14365 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BKN51_14375 ENOG4105ETE Transcriptional regulator (LacI family BKN51_14395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_14450 ENOG4105EEF Alkane 1-monooxygenase BKN51_14485 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) BKN51_14515 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BKN51_14540 ENOG4105CSH Transporter BKN51_14555 ENOG4105C26 Dehydrogenase BKN51_14620 ENOG4105DEF Extracellular solute-binding protein, family 5 BKN51_14645 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BKN51_14650 ENOG4105CPN adenine deaminase BKN51_14675 ENOG4105C26 Dehydrogenase BKN51_14680 ENOG4108WYP Transcriptional regulator BKN51_14775 ENOG4105E0A ABC, transporter BKN51_14780 ENOG4105TVJ transport system, permease BKN51_14785 ENOG4105DQ5 transport system permease protein BKN51_14795 ENOG4105Q26 Siderophore-interacting protein BKN51_14800 ENOG4105WQI isochorismatase BKN51_14805 ENOG4105WQI isochorismatase BKN51_14810 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BKN51_14815 ENOG4105E4F Isochorismate synthase BKN51_14820 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BKN51_14830 ENOG41065SU Two-component system sensor kinase BKN51_14835 ENOG4108KXV response regulator BKN51_14850 ENOG4105ECQ AraC Family Transcriptional Regulator BKN51_14860 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_14870 ENOG4105C6F GntR Family Transcriptional Regulator BKN51_14880 ENOG4105QE3 oxidoreductase BKN51_14885 ENOG4107R5R arsenical pump membrane protein BKN51_14890 ENOG4107HP6 Transcriptional regulator BKN51_14910 ENOG4107S9B Shikimate dehydrogenase BKN51_14920 ENOG4105CSH Transporter BKN51_14955 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BKN51_14960 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) BKN51_14975 ENOG4105ETE Transcriptional regulator (LacI family BKN51_14985 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BKN51_14995 ENOG4105CG3 alpha amylase, catalytic region BKN51_15005 ENOG4108ZHJ Organic hydroperoxide resistance protein BKN51_15015 ENOG4105R0I Feruloyl esterase BKN51_15020 ENOG4106T9R serine protease BKN51_15030 ENOG4108KXM LysR family Transcriptional regulator BKN51_15040 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap BKN51_15075 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BKN51_15090 ENOG41060NJ transcriptional regulator BKN51_15105 ENOG4105D9P serine threonine protein kinase BKN51_15150 ENOG4105CQB FAD linked oxidase domain protein BKN51_15175 ENOG4105CR4 methylisocitrate lyase BKN51_15180 ENOG4105DXD 2-methylcitrate dehydratase BKN51_15195 ENOG4105C26 Dehydrogenase BKN51_15200 ENOG4105C1G acyl-Coa dehydrogenase BKN51_15225 ENOG4105C0D helicase BKN51_15255 ENOG4105W1N transcriptional regulator BKN51_15275 ENOG4105KKX ATPase associated with various cellular activities aaa_5 BKN51_15280 ENOG4105DEG Vwa containing coxe family protein BKN51_15315 ENOG4105EPC oxidoreductase BKN51_15375 ENOG4105BZ1 (ABC) transporter BKN51_15380 ENOG4105BZ1 (ABC) transporter BKN51_15385 ENOG4107Z3H Transcriptional regulator, TetR family BKN51_15450 ENOG4105EXN Sulfate transport protein CysZ BKN51_15455 ENOG4105D94 Major Facilitator Superfamily BKN51_15500 ENOG4107RSM transcriptional regulator BKN51_15510 ENOG4107STQ Multicopper oxidase BKN51_15520 ENOG4105ERH Fumarylacetoacetate hydrolase BKN51_15525 ENOG4105CQB FAD linked oxidase domain protein BKN51_15530 ENOG4105C5R Aminotransferase BKN51_15565 ENOG4105D8K carboxyl transferase BKN51_15575 ENOG4107RCI amp-dependent synthetase and ligase BKN51_15605 ENOG4105CSR polyphosphate kinase 2 BKN51_15640 ENOG41090CE integral membrane protein BKN51_15645 ENOG4105F44 Two component transcriptional regulator, winged helix family BKN51_15650 ENOG4106F60 Histidine kinase BKN51_15665 ENOG4105EMU Dehydrogenase BKN51_15675 ENOG4105YVS arsR family transcriptional regulator BKN51_15745 ENOG4108IJ8 ABC transporter BKN51_15750 ENOG4106A3M Cytochrome p-450 BKN51_15770 ENOG4105KME endoribonuclease L-psp BKN51_15780 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BKN51_15790 ENOG4106JUT Streptomycin 3''-adenylyltransferase BKN51_15820 ENOG4108KX4 response regulator BKN51_15830 ENOG4108KXM LysR family Transcriptional regulator BKN51_15845 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BKN51_15860 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 BKN51_15865 ENOG4105DTQ mandelate racemase muconate lactonizing BKN51_15880 ENOG4107SET aldo keto reductase BKN51_15905 ENOG4105EG6 Saccharopine dehydrogenase BKN51_15910 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_15915 ENOG4105EW9 transcriptional regulator AsnC family BKN51_15920 ENOG4105EFZ amidohydrolase BKN51_15925 ENOG4105CSH Transporter BKN51_15930 ENOG4105C26 Dehydrogenase BKN51_15935 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) BKN51_15945 ENOG4105C1G acyl-Coa dehydrogenase BKN51_15955 ENOG4106T9R serine protease BKN51_15960 ENOG4108M8W Monooxygenase BKN51_16075 ENOG4108HMN Caspase domain BKN51_16215 ENOG4105BZU Histidine kinase BKN51_16220 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_16225 ENOG4106JDR secreted BKN51_16235 ENOG4105DWV Homoserine O-trans-acetylase BKN51_16250 ENOG4108IG5 Transcriptional regulator BKN51_16255 ENOG4108Z6Z Transcriptional regulator BKN51_16280 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BKN51_16285 ENOG4107SUZ Sodium/hydrogen exchanger family BKN51_16305 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BKN51_16350 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BKN51_16375 ENOG4105C5H ABC transporter BKN51_16400 ENOG4108DT4 serine threonine protein kinase BKN51_16425 ENOG4105BZU Histidine kinase BKN51_16430 ENOG4105EFQ Two component transcriptional regulator (Winged helix family BKN51_16435 ENOG4105DU1 integral membrane protein, terc BKN51_16440 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BKN51_16470 ENOG4107RCI amp-dependent synthetase and ligase BKN51_16475 ENOG4107EEY synthase BKN51_16480 ENOG4105C57 major facilitator superfamily BKN51_16495 ENOG4108762 serine threonine protein kinase BKN51_16500 ENOG4108762 serine threonine protein kinase BKN51_16630 ENOG4105F9F transposase BKN51_16645 ENOG41086VD Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BKN51_16655 ENOG4107EEY synthase BKN51_16660 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BKN51_16665 ENOG4105CPC Aldo Keto reductase BKN51_16670 ENOG4105W1N transcriptional regulator BKN51_16725 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BKN51_16740 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BKN51_16745 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BKN51_16750 ENOG4108K8U Glycerol operon regulatory protein BKN51_16755 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BKN51_16780 ENOG4105FBN Acid phosphatase BKN51_16790 ENOG4108W2Y isochorismatase BKN51_16810 ENOG4105EXC Acyl-transferase BKN51_16825 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BKN51_16835 ENOG4107RR1 TRANSCRIPTIONal BKN51_16855 ENOG4107JC6 Membrane BKN51_16865 ENOG4107RSM transcriptional regulator BKN51_16875 ENOG4105KPY Small multidrug resistance protein BKN51_16880 ENOG4106T9R serine protease BKN51_16885 ENOG4108KXM LysR family Transcriptional regulator BKN51_16900 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BKN51_16910 ENOG4108RZE Tetr family transcriptional regulator BKN51_16955 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_16970 ENOG4107RN6 Monooxygenase BKN51_17000 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BKN51_17010 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BKN51_17020 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BKN51_17040 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BKN51_17045 ENOG4105CPQ Dehydrogenase BKN51_17070 ENOG4107MMM Anti-sigma-factor antagonist BKN51_17075 ENOG4105FUA antagonist BKN51_17080 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BKN51_17105 ENOG4105YIP Tetr family transcriptional regulator BKN51_17120 ENOG4105DQ4 alcohol dehydrogenase BKN51_17145 ENOG4105GR3 Histidine kinase BKN51_17150 ENOG4105ETX regulatoR BKN51_17155 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_17160 ENOG4105D60 lipoprotein releasing system transmembrane protein BKN51_17180 ENOG4108DT4 serine threonine protein kinase BKN51_17190 ENOG4105EYF MMPL domain protein BKN51_17220 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_17225 ENOG4105BZU Histidine kinase BKN51_17230 ENOG4105MSB protein, conserved in bacteria BKN51_17245 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BKN51_17270 ENOG4105FDP GntR family transcriptional regulator BKN51_17290 ENOG4105EBM Alpha Beta Hydrolase Fold protein BKN51_17320 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BKN51_17340 ENOG4108M6P methyltransferase BKN51_17380 ENOG41073B4 coagulation factor 5 8 type domain-containing protein BKN51_17435 ENOG4105CIR epoxide hydrolase BKN51_17455 ENOG4105EQX glucarate dehydratase BKN51_17470 ENOG4106P37 HTH-type transcriptional regulator YjhI BKN51_17475 ENOG4105E9Z Nad-dependent epimerase dehydratase BKN51_17480 ENOG4105EEM helicase BKN51_17485 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) BKN51_17515 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BKN51_17525 ENOG4105CAT Cytidine monophosphate kinase BKN51_17545 ENOG4107S91 Sodium hydrogen exchanger BKN51_17560 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BKN51_17595 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BKN51_17600 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BKN51_17610 ENOG4105DRR Transcriptional regulator, GntR family BKN51_17630 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BKN51_17645 ENOG4105DSU hydrolase BKN51_17670 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BKN51_17675 ENOG4108VX5 3-methyladenine DNA glycosylase BKN51_17705 ENOG4105CH7 arginosuccinase BKN51_17710 ENOG4105CDH Citrulline--aspartate ligase BKN51_17715 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BKN51_17720 ENOG4105DBV ornithine carbamoyltransferase BKN51_17725 ENOG4105C8Y Acetylornithine aminotransferase BKN51_17730 ENOG4105CAS nag kinase BKN51_17735 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BKN51_17740 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BKN51_17770 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BKN51_17775 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BKN51_17785 ENOG4108RWN rrna methyltransferase BKN51_17790 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BKN51_17795 ENOG41084BS 50S ribosomal protein L35 BKN51_17810 ENOG4107XBN GntR Family Transcriptional Regulator BKN51_17820 ENOG4105KME endoribonuclease L-psp BKN51_17845 ENOG4105C6Z Gluconate BKN51_17850 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BKN51_17870 ENOG4105E2D ec 3.2.1.52 BKN51_17910 ENOG4108MRH transcriptional regulatory protein BKN51_17915 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BKN51_17920 ENOG4107QJT sodium dicarboxylate symporter BKN51_17930 ENOG4105KVH Transcriptional regulator BKN51_17975 ENOG4105C5X domain protein BKN51_18045 ENOG4105K5B UPF0225 protein BKN51_18090 ENOG4105CMG Carbohydrate kinase BKN51_18095 ENOG4105ETE Transcriptional regulator (LacI family BKN51_18110 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BKN51_18115 ENOG4105DU1 integral membrane protein, terc BKN51_18120 ENOG4105CJ1 ABC, transporter BKN51_18135 ENOG4105UPE Enoyl-CoA hydratase BKN51_18170 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BKN51_18180 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BKN51_18185 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_18205 ENOG4105ECB domain protein BKN51_18220 ENOG4105EPJ extracellular solute-binding protein family 1 BKN51_18255 ENOG4105F04 LysR family Transcriptional regulator BKN51_18270 ENOG4105C32 Amino acid ABC transporter (Permease) BKN51_18275 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BKN51_18280 ENOG4105C0Z ABC transporter BKN51_18285 ENOG4108IV0 ABC, transporter BKN51_18300 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BKN51_18305 ENOG4105CJQ hydrolase, family 31 BKN51_18310 ENOG4105E98 transcriptional regulator DeoR family BKN51_18330 ENOG4105EG2 ABC transporter, permease BKN51_18350 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BKN51_18370 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN51_18380 ENOG4105F9F transposase BKN51_18390 ENOG4108TZY GntR Family Transcriptional Regulator BKN51_18400 ENOG4105C26 Dehydrogenase BKN51_18405 ENOG4105C85 amino acid BKN51_18410 ENOG4105CSV Glutaminase BKN51_18420 ENOG4107RSM transcriptional regulator BKN51_18445 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BKN51_18490 ENOG4105EDW glycosyl transferase, family 39 BKN51_18505 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_18510 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_18525 ENOG4105TVJ transport system, permease BKN51_18530 ENOG4105DQ5 transport system permease protein BKN51_18535 ENOG4105BZ1 (ABC) transporter BKN51_18540 ENOG4105BZ1 (ABC) transporter BKN51_18550 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BKN51_18560 ENOG4105BZ1 (ABC) transporter BKN51_18620 ENOG4105C0Z ABC transporter BKN51_18625 ENOG4108IV0 ABC, transporter BKN51_18630 ENOG4105C32 Amino acid ABC transporter (Permease) BKN51_18685 ENOG4105CHP RNA polymerase BKN51_18715 ENOG4105JZI cytochrome P450 BKN51_18795 ENOG4105GVJ transcriptional regulator BKN51_18820 ENOG4107TPY serine threonine protein kinase BKN51_18825 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BKN51_18830 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BKN51_18855 ENOG4108J08 Csbd family BKN51_18890 ENOG4108IUE nitrate reductase beta subunit BKN51_18940 ENOG4108S01 response regulator BKN51_18955 ENOG4105F0K SARP family transcriptional regulator BKN51_18965 ENOG4105CS2 ec 3.2.1.21 BKN51_18980 ENOG4105E98 transcriptional regulator DeoR family BKN51_19010 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BKN51_19020 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BKN51_19030 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BKN51_19045 ENOG4106A3M Cytochrome p-450 BKN51_19100 ENOG4105VUF Transcriptional regulator BKN51_19105 ENOG4106T9R serine protease BKN51_19150 ENOG4105CJ1 ABC, transporter BKN51_19160 ENOG4106JDR secreted BKN51_19200 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_19205 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_19225 ENOG4108S01 response regulator BKN51_19235 ENOG4107RSM transcriptional regulator BKN51_19260 ENOG4108KB2 LysR family Transcriptional regulator BKN51_19295 ENOG410630P Transcriptional regulator BKN51_19310 ENOG4105F9F transposase BKN51_19340 ENOG4107RCI amp-dependent synthetase and ligase BKN51_19350 ENOG4106T9R serine protease BKN51_19420 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BKN51_19425 ENOG4105MWK D-amino acid dehydrogenase, small subunit BKN51_19430 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BKN51_19435 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BKN51_19440 ENOG4107ZHV Transcriptional regulator BKN51_19455 ENOG4105DNP FAD linked oxidase domain protein BKN51_19465 ENOG4105CIK Amidinotransferase BKN51_19475 ENOG4105D74 hydrolase BKN51_19495 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_19500 ENOG4105ENE Histidine kinase BKN51_19530 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_19535 ENOG4105BZU Histidine kinase BKN51_19555 ENOG4105H3G oxidoreductase BKN51_19575 ENOG4105CSH Transporter BKN51_19580 ENOG4105E0A ABC, transporter BKN51_19585 ENOG4105EHG Permease protein BKN51_19645 ENOG4108K8S endonuclease I BKN51_19665 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_19670 ENOG4105BZU Histidine kinase BKN51_19695 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_19705 ENOG4105BZU Histidine kinase BKN51_19710 ENOG4108UAJ Transcriptional regulator BKN51_19725 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BKN51_19745 ENOG4108HMN Caspase domain BKN51_19755 ENOG4105DJ2 Major Facilitator Superfamily BKN51_19760 ENOG41073TP transcriptional regulator BKN51_19790 ENOG4105K63 Thioredoxin BKN51_19820 ENOG4107WYG Transcriptional regulator, luxr family BKN51_19880 ENOG4105C57 major facilitator superfamily BKN51_19895 ENOG4107QNK )-transporter BKN51_19930 ENOG4105CH6 catalase BKN51_19945 ENOG41076QQ Glycosyl transferase, family 2 BKN51_19970 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BKN51_19975 ENOG4105JJR Histidine kinase BKN51_19980 ENOG4105F44 Two component transcriptional regulator, winged helix family BKN51_19985 ENOG4105F44 Two component transcriptional regulator, winged helix family BKN51_20040 ENOG4105F9F transposase BKN51_20060 ENOG4105RFA Lsr2-like protein BKN51_20075 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BKN51_20110 ENOG4105EMN RNA polymerase sigma factor BKN51_20115 ENOG4105D9P serine threonine protein kinase BKN51_20195 ENOG4108R0M Aminoglycoside BKN51_20200 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BKN51_20205 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BKN51_20210 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BKN51_20225 ENOG4105G9B Transcriptional regulator BKN51_20230 ENOG4105ETS cytosine purines uracil thiamine allantoin BKN51_20275 ENOG4107R6F Alpha Beta Hydrolase Fold protein BKN51_20290 ENOG4105CAQ asparagine synthetase BKN51_20310 ENOG4105C3M thioredoxin reductase BKN51_20345 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BKN51_20405 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BKN51_20410 ENOG4105EMU Dehydrogenase BKN51_20420 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BKN51_20440 ENOG4105GFR rna polymerase sigma factor BKN51_20465 ENOG4107RTG Major Facilitator superfamily BKN51_20470 ENOG4107RSM transcriptional regulator BKN51_20515 ENOG4108VB1 regulatoR BKN51_20600 ENOG4105EC2 ftsk spoIIIe BKN51_20615 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_20625 ENOG4106F1P AAA ATPase, central domain protein BKN51_20645 ENOG4108FKH Transglycosylase SLT domain BKN51_20680 ENOG4107VHA regulatoR BKN51_20710 ENOG4105CPF Cell wall formation (By similarity) BKN51_20720 ENOG4105DG4 malate L-lactate dehydrogenase BKN51_20725 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BKN51_20820 ENOG4105MP0 transposase BKN51_20915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BKN51_20930 ENOG4107UIE peptidase BKN51_20940 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) BKN51_20955 ENOG41060M0 Crispr-associated protein, cse4 family BKN51_21050 ENOG4105G6Z alkaline phosphatase BKN51_21055 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_21060 ENOG4105BZU Histidine kinase BKN51_21070 ENOG4105VBF alkaline shock protein BKN51_21095 ENOG4105CHR reductase BKN51_21105 ENOG4105K6V RNA polymerase BKN51_21125 ENOG4105EV9 Alpha Beta Hydrolase BKN51_21145 ENOG4105FDF Could be involved in DNA repair (By similarity) BKN51_21180 ENOG41082SX arsR family transcriptional regulator BKN51_21195 ENOG4105CIR epoxide hydrolase BKN51_21250 ENOG41082BM Transcriptional regulator, arsr family BKN51_21260 ENOG4105C9U ATP-dependent DNA helicase RecQ BKN51_21285 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB BKN51_21300 ENOG4105CPC Aldo Keto reductase BKN51_21315 ENOG4108RZE Tetr family transcriptional regulator BKN51_21325 ENOG4105CPC Aldo Keto reductase BKN51_21340 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BKN51_21355 ENOG4105DKQ ROK family BKN51_21380 ENOG4105J7D transcriptional regulator BKN51_21405 ENOG4107R33 ppx gppa phosphatase BKN51_21410 ENOG4105DYW oxidoreductase BKN51_21415 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BKN51_21445 ENOG4105C9B Cysteine desulfurase BKN51_21460 ENOG4108ZHR arsR family transcriptional regulator BKN51_21470 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BKN51_21495 ENOG4107VQS DivIVA family BKN51_21505 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BKN51_21510 ENOG4105DFA alanine racemase domain protein BKN51_21515 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BKN51_21525 ENOG4105RNG membrane BKN51_21530 ENOG4105K6V RNA polymerase BKN51_21545 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BKN51_21565 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase BKN51_21580 ENOG4106JDR secreted BKN51_21590 ENOG4105CBC glutamate synthase BKN51_21600 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BKN51_21605 ENOG4105CH2 amidohydrolase BKN51_21615 ENOG4105C5F glutamine synthetase BKN51_21620 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BKN51_21625 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BKN51_21630 ENOG4105DK0 Indole-3-glycerol phosphate synthase BKN51_21640 ENOG4105CRQ synthase (Component I) BKN51_21675 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BKN51_21685 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BKN51_21690 ENOG4108IG5 Transcriptional regulator BKN51_21720 ENOG4105CIG ABC transporter BKN51_21750 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BKN51_21755 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BKN51_21765 ENOG4105C1G acyl-Coa dehydrogenase BKN51_21790 ENOG4108Z4X TRANSCRIPTIONal BKN51_21795 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) BKN51_21805 ENOG4108IG5 Transcriptional regulator BKN51_21810 ENOG4105EYF MMPL domain protein BKN51_21815 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BKN51_21820 ENOG4105CIH Imidazole acetol-phosphate transaminase BKN51_21825 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BKN51_21835 ENOG4108ZRZ Transcriptional regulator (AsnC family) BKN51_21845 ENOG4108S01 response regulator BKN51_21850 ENOG4108Q9V regulatoR BKN51_21895 ENOG4105EC2 ftsk spoIIIe BKN51_21960 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_21970 ENOG4108IYU L-aspartate oxidase BKN51_21975 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BKN51_22000 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BKN51_22005 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BKN51_22010 ENOG4105CHH sulfate transporter BKN51_22015 ENOG4105CHH sulfate transporter BKN51_22020 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BKN51_22025 ENOG4106A3M Cytochrome p-450 BKN51_22040 ENOG4105JNK Glycosyl transferase (Group 1 BKN51_22105 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BKN51_22115 ENOG4107UDY cytochrome C BKN51_22120 ENOG4105CCU oxidase (Subunit III) BKN51_22135 ENOG4108I0Q anthranilate phosphoribosyltransferase BKN51_22140 ENOG4105ECQ AraC Family Transcriptional Regulator BKN51_22160 ENOG4108ZRS Part of cytochrome c oxidase, its function is BKN51_22165 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) BKN51_22200 ENOG4105CPC Aldo Keto reductase BKN51_22210 ENOG4105C8V SAICAR synthetase BKN51_22225 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BKN51_22235 ENOG4105CM2 brancheD-chain amino acid aminotransferase BKN51_22255 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BKN51_22330 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BKN51_22345 ENOG41067SE Tetr family transcriptional regulator BKN51_22355 ENOG4105EMU Dehydrogenase BKN51_22360 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BKN51_22370 ENOG4105D78 K07001 NTE family protein BKN51_22380 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BKN51_22415 ENOG4105C0B DNA polymerase III (alpha subunit) BKN51_22445 ENOG4108IJ0 Aspartate ammonia-lyase BKN51_22455 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BKN51_22475 ENOG4105W1N transcriptional regulator BKN51_22480 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_22505 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_22525 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BKN51_22550 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BKN51_22555 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BKN51_22570 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BKN51_22590 ENOG4107QN2 dihydrolipoyl dehydrogenase BKN51_22600 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) BKN51_22605 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BKN51_22610 ENOG4105W8H transhydrogenase (subunit alpha BKN51_22615 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BKN51_22620 ENOG4105EJ2 Transcriptional regulator BKN51_22645 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_22655 ENOG4108JCI Transcriptional regulator BKN51_22685 ENOG4105FF5 Membrane BKN51_22695 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BKN51_22720 ENOG4107XFJ UPF0246 protein BKN51_22725 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap BKN51_22735 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_22740 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_22745 ENOG4108ZXC Two component transcriptional regulator, luxr family BKN51_22760 ENOG4105C1J atp-dependent rna helicase BKN51_22765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BKN51_22775 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap BKN51_22795 ENOG4105DJ2 Major Facilitator Superfamily BKN51_22800 ENOG4105C6F GntR Family Transcriptional Regulator BKN51_22815 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BKN51_22820 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BKN51_22825 ENOG4105DZP Membrane-associated zinc metalloprotease BKN51_22830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BKN51_22845 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) BKN51_22855 ENOG4105C3R Methionine synthase BKN51_22860 ENOG4107U9B transcriptional regulator BKN51_22865 ENOG41082A2 Alpha beta hydrolase BKN51_22895 ENOG4105VZ8 Transcriptional regulator BKN51_22905 ENOG4105DGI Alkaline phosphatase BKN51_22915 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BKN51_22995 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BKN51_23000 ENOG4105NTW Transcriptional regulator BKN51_23005 ENOG4107QVI Methyltransferase, type 11 BKN51_23015 ENOG4105EBR Carboxylesterase BKN51_23025 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BKN51_23030 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BKN51_23035 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BKN51_23040 ENOG4105CE9 30S ribosomal protein S2 BKN51_23050 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN51_23055 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BKN51_23065 ENOG4105C0P Mg chelatase subunit ChlI BKN51_23070 ENOG41080R2 UPF0102 protein BKN51_23080 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BKN51_23085 ENOG4107QYR Signal peptidase i BKN51_23090 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BKN51_23095 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BKN51_23100 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BKN51_23110 ENOG4105K5M 30s ribosomal protein S16 BKN51_23140 ENOG4105FDF Could be involved in DNA repair (By similarity) BKN51_23150 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BKN51_23210 ENOG4105K4P CoA-binding domain protein BKN51_23240 ENOG4105VT2 5-hydroxyisourate hydrolase BKN51_23250 ENOG4106JDR secreted BKN51_23260 ENOG4105J7D transcriptional regulator BKN51_23275 ENOG4105C7N Xanthine uracil vitamin C permease BKN51_23280 ENOG4107Y2X deaminase BKN51_23285 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BKN51_23290 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BKN51_23325 ENOG4105CIR epoxide hydrolase BKN51_23355 ENOG4107R9S Malate synthase BKN51_23360 ENOG41069M3 Transcriptional regulator BKN51_23370 ENOG4105C57 major facilitator superfamily BKN51_23380 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BKN51_23395 ENOG4108375 Acylphosphatase (EC 3.6.1.7) BKN51_23415 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BKN51_23420 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BKN51_23425 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BKN51_23435 ENOG4105CAQ asparagine synthetase BKN51_23450 ENOG4105CZV ABC transporter BKN51_23455 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BKN51_23470 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BKN51_23475 ENOG4105ETE Transcriptional regulator (LacI family BKN51_23480 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BKN51_23490 ENOG41062B0 ABC transporter, permease BKN51_23495 ENOG4105C2J ABC transporter BKN51_23500 ENOG4105EDK PfkB domain protein BKN51_23505 ENOG4105DH8 myo-inositol catabolism BKN51_23510 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BKN51_23520 ENOG4108IG5 Transcriptional regulator BKN51_23530 ENOG4105C0W non-ribosomal peptide synthetase BKN51_23570 ENOG4105C7B Threonine dehydratase BKN51_23605 ENOG4105CPC Aldo Keto reductase BKN51_23620 ENOG4107HP6 Transcriptional regulator BKN51_23625 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BKN51_23630 ENOG4105F2Z 3-oxoadipate enol-lactonase BKN51_23645 ENOG4105CHU acetyl-coa acetyltransferase BKN51_23665 ENOG4105BZW Glycerate kinase BKN51_23710 ENOG4105JXH GntR family transcriptional regulator BKN51_23715 ENOG4105CNN ABC, transporter BKN51_23720 ENOG4105C2J ABC transporter BKN51_23735 ENOG4105DIA mandelate racemase muconate lactonizing BKN51_23740 ENOG4105ERH Fumarylacetoacetate hydrolase BKN51_23745 ENOG4105C2C drug resistance transporter, Bcr CflA BKN51_23760 ENOG4105PDP Short chain dehydrogenase BKN51_23770 ENOG4107SQD Transcriptional regulator, GntR family BKN51_23775 ENOG4105E0A ABC, transporter BKN51_23790 ENOG41073TP transcriptional regulator BKN51_23795 ENOG4105EJQ L-serine dehydratase BKN51_23800 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BKN51_23805 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BKN51_23810 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BKN51_23815 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BKN51_23820 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BKN51_23835 ENOG4105C26 Dehydrogenase BKN51_23840 ENOG4108Z86 Glutamine amidotransferase BKN51_23845 ENOG4105C5F glutamine synthetase BKN51_23855 ENOG4105C5S asparaginyl-tRNA synthetase BKN51_23865 ENOG4107SM8 Adenylate Guanylate cyclase BKN51_23890 ENOG4107U9B transcriptional regulator BKN51_23895 ENOG4105CZV ABC transporter BKN51_23925 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BKN51_23930 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BKN51_23935 ENOG41084BZ 50S ribosomal protein L32 BKN51_23965 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BKN51_23970 ENOG4106H78 methyltransferase BKN51_23975 ENOG4105EEM helicase BKN51_23980 ENOG4108HMN Caspase domain BKN51_23985 ENOG4105DEN Luciferase family BKN51_24065 ENOG4107VHA regulatoR BKN51_24075 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BKN51_24080 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_24100 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BKN51_24120 ENOG4105DP4 dak2 domain fusion protein ylov BKN51_24125 ENOG4105VB9 50S ribosomal protein l28 BKN51_24130 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BKN51_24135 ENOG4108Z0R Transferase BKN51_24165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BKN51_24175 ENOG4105BZU Histidine kinase BKN51_24180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN51_24205 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BKN51_24210 ENOG4105HDK L-asparaginase BKN51_24220 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BKN51_24230 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) BKN51_24245 ENOG4105K70 DNA-binding protein BKN51_24250 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BKN51_24255 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BKN51_24260 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region BKN51_24290 ENOG4105EC2 ftsk spoIIIe BKN51_24305 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_24340 ENOG4105F44 Two component transcriptional regulator, winged helix family BKN51_24345 ENOG4106F1P AAA ATPase, central domain protein BKN51_24355 ENOG4105ETX regulatoR BKN51_24360 ENOG4105EB3 Histidine kinase BKN51_24390 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BKN51_24465 ENOG4105E2Y ABC, transporter BKN51_24475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_24480 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN51_24485 ENOG4105DEF Extracellular solute-binding protein, family 5 BKN51_24495 ENOG4105DDW LysR family Transcriptional regulator BKN51_24545 ENOG4105BZU Histidine kinase BKN51_24550 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_24570 ENOG4105CIR epoxide hydrolase BKN51_24580 ENOG4105E8R UPF0173 metal-dependent hydrolase BKN51_24605 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BKN51_24615 ENOG4105ERH Fumarylacetoacetate hydrolase BKN51_24640 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BKN51_24645 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BKN51_24650 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_24690 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BKN51_24695 ENOG4108ZP8 Acetolactate synthase small subunit BKN51_24710 ENOG4105C01 Dihydroxy-acid dehydratase BKN51_24760 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BKN51_24765 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_24770 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BKN51_24785 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BKN51_24805 ENOG4105C5X domain protein BKN51_24810 ENOG410849A acetyltransferase, (GNAT) family BKN51_24815 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BKN51_24825 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_24830 ENOG4108KQI regulatory protein luxr BKN51_24850 ENOG4105C10 Electron transfer flavoprotein BKN51_24860 ENOG4105EPR degv family BKN51_24870 ENOG4108KQJ Type 11 methyltransferase BKN51_24880 ENOG4108V06 Glutathione peroxidase BKN51_24910 ENOG4107R9S Malate synthase BKN51_24940 ENOG4105EVB acetyltransferase BKN51_24950 ENOG4105ZXU NLP P60 protein BKN51_24955 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BKN51_24960 ENOG41061H0 Monooxygenase BKN51_24965 ENOG4105EBR Carboxylesterase BKN51_24970 ENOG4105CY0 Metallo-Beta-Lactamase BKN51_24995 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BKN51_25075 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_25080 ENOG4105UPE Enoyl-CoA hydratase BKN51_25085 ENOG4105DKW ABC transporter BKN51_25095 ENOG4105KHC sulfurtransferase BKN51_25105 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BKN51_25130 ENOG41067TZ transcriptional regulator, MarR family BKN51_25140 ENOG4105CWX Alpha-1,2-mannosidase BKN51_25145 ENOG4105ETE Transcriptional regulator (LacI family BKN51_25155 ENOG4105C2J ABC transporter BKN51_25160 ENOG4105CNN ABC, transporter BKN51_25175 ENOG4108HRK Histidine kinase BKN51_25180 ENOG4108NEV two component transcriptional regulator, LytTR family BKN51_25200 ENOG4107QN1 sodium solute BKN51_25205 ENOG4105CR4 methylisocitrate lyase BKN51_25210 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BKN51_25215 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BKN51_25245 ENOG4105CHU acetyl-coa acetyltransferase BKN51_25280 ENOG4108QER Adenylate cyclase BKN51_25285 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BKN51_25295 ENOG4105D03 DNA-3-methyladenine glycosylase II BKN51_25300 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_25320 ENOG4105D7A ATP-binding protein BKN51_25325 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BKN51_25355 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BKN51_25360 ENOG4105CIF Ornithine Cyclodeaminase BKN51_25365 ENOG4105CRW Short chain fatty acid transporter BKN51_25425 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap BKN51_25450 ENOG4108RF4 Tetr family transcriptional regulator BKN51_25475 ENOG4108SUT Major Facilitator Superfamily BKN51_25520 ENOG4108YZG isomerase BKN51_25530 ENOG4106UDK Cellulose-binding, family II BKN51_25540 ENOG4108MMM RNA Polymerase BKN51_25545 ENOG4105VEQ Cold shock protein BKN51_25575 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BKN51_25585 ENOG4107RN3 metallophosphoesterase BKN51_25625 ENOG4107YBY Hydrolase BKN51_25635 ENOG4105MGM doxx family BKN51_25640 ENOG4105MGM doxx family BKN51_25655 ENOG4105GWZ Roadblock lc7 family protein BKN51_25675 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BKN51_25690 ENOG4105CHR reductase BKN51_25700 ENOG4105BZU Histidine kinase BKN51_25710 ENOG4107TB5 TRANSCRIPTIONal BKN51_25720 ENOG4107RN6 Monooxygenase BKN51_25825 ENOG4105C0B DNA polymerase III (alpha subunit) BKN51_25880 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BKN51_25885 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BKN51_25895 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BKN51_25940 ENOG4105KXX peptidase s58 dmpa BKN51_25955 ENOG4107RKP Nicotinate phosphoribosyltransferase BKN51_25960 ENOG4108RWI nicotinamidase BKN51_25965 ENOG4108UHU Aldolase BKN51_25975 ENOG4105VKD bioY protein BKN51_26010 ENOG4105BZ9 Cytochrome C oxidase, subunit I BKN51_26025 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BKN51_26045 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BKN51_26075 ENOG4105F7P transcriptional regulator AsnC family BKN51_26100 ENOG4108UTZ Dihydroxyacetone kinase BKN51_26105 ENOG4105CMT Dihydroxyacetone kinase BKN51_26140 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) BKN51_26155 ENOG4105ECQ AraC Family Transcriptional Regulator BKN51_26185 ENOG4105RFZ Methylmalonyl-coA mutase BKN51_26205 ENOG4105N14 lysine exporter protein LysE YggA BKN51_26210 ENOG4105N14 lysine exporter protein LysE YggA BKN51_26215 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BKN51_26230 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BKN51_26240 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BKN51_26245 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BKN51_26250 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BKN51_26255 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BKN51_26260 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BKN51_26265 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) BKN51_26270 ENOG4106DE0 ATP synthase BKN51_26275 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) BKN51_26285 ENOG4105ESV Glycosyl transferase, family 4 BKN51_26300 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BKN51_26305 ENOG4105DK2 UPF0207 protein BKN51_26315 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids BKN51_26350 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BKN51_26355 ENOG4105VFB Binds the 23S rRNA (By similarity) BKN51_26365 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BKN51_26375 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BKN51_26380 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BKN51_26385 ENOG4105D6E homoserine dehydrogenase BKN51_26390 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BKN51_26395 ENOG4105C75 arginyL-tRNA synthetase BKN51_26415 ENOG4105CIR epoxide hydrolase BKN51_26460 ENOG4107R0V Pyruvate dehydrogenase BKN51_26465 ENOG4105CPP Dehydrogenase, E1 component BKN51_26475 ENOG4105CAT Cytidine monophosphate kinase BKN51_26530 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BKN51_26535 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BKN51_26540 ENOG410880H cysteine synthase BKN51_26550 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BKN51_26555 ENOG4105EHG Permease protein BKN51_26560 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BKN51_26570 ENOG4107EFR Flavocytochrome c BKN51_26585 ENOG4105C6Y Udp-glucose 6-dehydrogenase BKN51_26605 ENOG4105CHP RNA polymerase BKN51_26620 ENOG41067TZ transcriptional regulator, MarR family BKN51_26635 ENOG4108RYK Nad-dependent epimerase dehydratase BKN51_26660 ENOG4105CHR reductase BKN51_26670 ENOG4105XYF acetyltransferase BKN51_26685 ENOG4105C8Y Acetylornithine aminotransferase BKN51_26690 ENOG4105EX0 alpha-galactosidase BKN51_26715 ENOG4105C7K acetolactate synthase BKN51_26725 ENOG4105MWK D-amino acid dehydrogenase, small subunit BKN51_26730 ENOG4105CHF Glutathione S-transferase BKN51_26750 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) BKN51_26755 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d BKN51_26770 ENOG4108FN7 Aldo keto reductase BKN51_26785 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_26815 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BKN51_26825 ENOG4108JPW Aminotransferase BKN51_26880 ENOG4105BZU Histidine kinase BKN51_26885 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_26890 ENOG4105EYF MMPL domain protein BKN51_26900 ENOG4105BZ1 (ABC) transporter BKN51_26915 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN51_26920 ENOG4105CHU acetyl-coa acetyltransferase BKN51_26935 ENOG4105C1G acyl-Coa dehydrogenase BKN51_26940 ENOG4105C1G acyl-Coa dehydrogenase BKN51_26955 ENOG4105EMU Dehydrogenase BKN51_26965 ENOG4105C1G acyl-Coa dehydrogenase BKN51_26975 ENOG4107QX3 carboxylase BKN51_26980 ENOG4108TCJ secreted hydrolase BKN51_26995 ENOG4105DWV Homoserine O-trans-acetylase BKN51_27005 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BKN51_27010 ENOG4105VUN Transcriptional regulator BKN51_27020 ENOG4108K8K Transcriptional regulator BKN51_27040 ENOG4105DCF alanine dehydrogenase BKN51_27055 ENOG4105BZ1 (ABC) transporter BKN51_27075 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BKN51_27095 ENOG4108YYD acetyltransferase BKN51_27105 ENOG4105E90 ABC transporter BKN51_27110 ENOG4105E90 ABC transporter BKN51_27115 ENOG4108IJ8 ABC transporter BKN51_27130 ENOG4105C6K Malic enzyme BKN51_27135 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BKN51_27155 ENOG4108ZM9 phosphoglycerate mutase BKN51_27170 ENOG4105CBD Diacylglycerol kinase BKN51_27195 ENOG4108Z66 YbaK ebsC protein BKN51_27210 ENOG4108RAV Conserved protein BKN51_27215 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BKN51_27255 ENOG4105C2N RNA methyltransferase TrmH family group 3 BKN51_27260 ENOG4107URF beta-phospho-glucomutase BKN51_27270 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BKN51_27275 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea BKN51_27285 ENOG4108MKR lipoprotein lpqb BKN51_27290 ENOG4105BZU Histidine kinase BKN51_27295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN51_27300 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase BKN51_27305 ENOG4105VQD rieske 2fe-2S domain-containing protein BKN51_27310 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region BKN51_27320 ENOG4105F76 Sarcosine oxidase BKN51_27325 ENOG4105DVW rieske (2Fe-2S) BKN51_27350 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BKN51_27365 ENOG4105CUB amino acid BKN51_27380 ENOG4105EIP mannose-6-phosphate isomerase BKN51_27390 ENOG4105W49 UPF0434 protein BKN51_27410 ENOG410836F Transposase BKN51_27420 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BKN51_27425 ENOG4107XZ0 Peptidase M50 BKN51_27440 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) BKN51_27460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN51_27470 ENOG4107USK Extracellular solute-binding protein, family 5 BKN51_27475 ENOG4105CI3 gtp-binding protein typa BKN51_27485 ENOG4105C31 Tryptophanyl-tRNA synthetase BKN51_27495 ENOG4105JJR Histidine kinase BKN51_27500 ENOG4105ETX regulatoR BKN51_27510 ENOG4105CJ1 ABC, transporter BKN51_27520 ENOG4108UCS ABC, transporter BKN51_27525 ENOG4105E0C molybdate abc transporter BKN51_27535 ENOG4105KZX Pterin carbinolamine dehydratase BKN51_27545 ENOG41086VY Fic/DOC family BKN51_27565 ENOG4105IIU Aminopeptidase BKN51_27570 ENOG4105C3G gtp-binding protein BKN51_27585 ENOG4105EYH Exonuclease BKN51_27615 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BKN51_27625 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BKN51_27650 ENOG4105CAY ferredoxin--nadp reductase BKN51_27655 ENOG4105C9Q fumarate hydratase class II BKN51_27675 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) BKN51_27710 ENOG4108IAB Phoh family BKN51_27760 ENOG4105C7Z Conserved Protein BKN51_27770 ENOG4107S1Q Phosphatase BKN51_27780 ENOG4105T1M mycothiol conjugate amidase mca BKN51_27790 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BKN51_27800 ENOG4105EW9 transcriptional regulator AsnC family BKN51_27805 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BKN51_27870 ENOG4105CHU acetyl-coa acetyltransferase BKN51_27875 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_27880 ENOG4105CUC YeeE YedE family protein BKN51_27925 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BKN51_27950 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BKN51_27960 ENOG4108RZE Tetr family transcriptional regulator BKN51_27965 ENOG4106A3M Cytochrome p-450 BKN51_27970 ENOG4105CVJ phosphoglycerate mutase BKN51_27985 ENOG4105C1G acyl-Coa dehydrogenase BKN51_28000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN51_28020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN51_28030 ENOG4105C1G acyl-Coa dehydrogenase BKN51_28100 ENOG4108KAM Transcriptional regulator BKN51_28115 ENOG4105CEP NADH dehydrogenase BKN51_28125 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BKN51_28140 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_28145 ENOG4108JQ7 (ABC) transporter BKN51_28150 ENOG4105C3U ABC transporter BKN51_28155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_28160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN51_28190 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BKN51_28205 ENOG4108JCI Transcriptional regulator BKN51_28225 ENOG410650H (LipO)protein BKN51_28230 ENOG4105DBE peroxidase BKN51_28250 ENOG4105DA5 (ABC) transporter BKN51_28265 ENOG4105KVH Transcriptional regulator BKN51_28325 ENOG4108IG5 Transcriptional regulator BKN51_28340 ENOG4105BZU Histidine kinase BKN51_28345 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BKN51_28370 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BKN51_28375 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BKN51_28390 ENOG4107RCI amp-dependent synthetase and ligase BKN51_28395 ENOG4105C5H ABC transporter BKN51_28400 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BKN51_28405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BKN51_28410 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BKN51_28425 ENOG4105F8V Hydrolase, tatD family BKN51_28430 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BKN51_28455 ENOG4105CRQ synthase (Component I) BKN51_28460 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BKN51_28520 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BKN51_28525 ENOG4105E2D ec 3.2.1.52 BKN51_28535 ENOG4108RPX mosc domain containing protein BKN51_28550 ENOG4105BZU Histidine kinase BKN51_28555 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_28590 ENOG4105DXX methyltransferase BKN51_28600 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase BKN51_28610 ENOG4105D9U N-acetyltransferase BKN51_28630 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN51_28645 ENOG4105C0D helicase BKN51_28655 ENOG4108I5C dEAD DEAH box helicase BKN51_28730 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BKN51_28735 ENOG4105CMR udp-glucose 4-epimerase BKN51_28745 ENOG4105BZU Histidine kinase BKN51_28750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BKN51_28785 ENOG4105C0H protease BKN51_28795 ENOG4105E98 transcriptional regulator DeoR family BKN51_28820 ENOG4105ETX regulatoR BKN51_28825 ENOG4107ZT3 family UPF0126 BKN51_28830 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_28850 ENOG4105CIR epoxide hydrolase BKN51_28860 ENOG4108KC1 acyl-Coa dehydrogenase BKN51_28865 ENOG4108IJG ABC transporter substrate-binding protein BKN51_28880 ENOG4105C57 major facilitator superfamily BKN51_28885 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_28890 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_28910 ENOG4105CQB FAD linked oxidase domain protein BKN51_28920 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase BKN51_28955 ENOG4105DQ4 alcohol dehydrogenase BKN51_28995 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BKN51_29050 ENOG4105EMU Dehydrogenase BKN51_29055 ENOG4105MKU Transcriptional regulator BKN51_29060 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BKN51_29070 ENOG4105CHP RNA polymerase BKN51_29075 ENOG4108Z4X TRANSCRIPTIONal BKN51_29090 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) BKN51_29095 ENOG4106NZI LysR family Transcriptional regulator BKN51_29105 ENOG4105EXC Acyl-transferase BKN51_29150 ENOG4105DKQ ROK family BKN51_29165 ENOG4107RGD Major Facilitator superfamily BKN51_29170 ENOG4105CFM UPF0317 protein BKN51_29175 ENOG4105E7W lamb ycsf family protein BKN51_29180 ENOG4105P4J Allophanate hydrolase, subunit 1 BKN51_29185 ENOG4107R7A Allophanate hydrolase subunit 2 BKN51_29190 ENOG4105CF1 Alkylated DNA repair protein BKN51_29205 ENOG4105KST dependent repressor BKN51_29215 ENOG4105EFZ amidohydrolase BKN51_29220 ENOG41060WC Enoyl-CoA hydratase BKN51_29225 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_29240 ENOG4105C1G acyl-Coa dehydrogenase BKN51_29245 ENOG4107QJT sodium dicarboxylate symporter BKN51_29255 ENOG4105E4F Isochorismate synthase BKN51_29345 ENOG4108IUX (ABC) transporter BKN51_29350 ENOG4105RHA ABC transporter, permease BKN51_29355 ENOG4105CVP deoxyribo-dipyrimidine photolyase BKN51_29375 ENOG4105C1G acyl-Coa dehydrogenase BKN51_29390 ENOG4105CPN adenine deaminase BKN51_29400 ENOG4107WI4 Aldose-1-epimerase BKN51_29405 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_29420 ENOG4105J7D transcriptional regulator BKN51_29450 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BKN51_29460 ENOG4107UWC ABC, transporter BKN51_29465 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BKN51_29475 ENOG4105DHQ Histidine kinase BKN51_29505 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BKN51_29510 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BKN51_29520 ENOG4105CQM Urea amidohydrolase subunit alpha BKN51_29525 ENOG4105KI2 Urea amidohydrolase subunit beta BKN51_29530 ENOG4108YZ9 Urea amidohydrolase subunit gamma BKN51_29555 ENOG4105Y7M Transcriptional regulator, TetR family BKN51_29570 ENOG4105CJ1 ABC, transporter BKN51_29585 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_29590 ENOG4105ED2 Beta-lactamase BKN51_29600 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BKN51_29610 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_29615 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_29630 ENOG41086IN PA14 BKN51_29635 ENOG4105F44 Two component transcriptional regulator, winged helix family BKN51_29640 ENOG4106F60 Histidine kinase BKN51_29660 ENOG4105FCS tRNA rRNA methyltransferase BKN51_29690 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BKN51_29695 ENOG4105EHG Permease protein BKN51_29700 ENOG4107R4I Periplasmic binding protein BKN51_29720 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BKN51_29725 ENOG4105CHR reductase BKN51_29750 ENOG4107SFI Major Facilitator superfamily BKN51_29760 ENOG4105C7N Xanthine uracil vitamin C permease BKN51_29800 ENOG4105VEQ Cold shock protein BKN51_29810 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BKN51_29820 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta BKN51_29835 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_29840 ENOG4107TIF Phenazine biosynthesis protein, PhzF family BKN51_29845 ENOG410901E Membrane BKN51_29885 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BKN51_29910 ENOG4108RIR Molybdenum cofactor biosynthesis protein BKN51_29945 ENOG4105GWZ Roadblock lc7 family protein BKN51_29960 ENOG4105GWZ Roadblock lc7 family protein BKN51_29970 ENOG4105D2X ABC transporter substrate-binding protein BKN51_29975 ENOG4105GVF (ABC) transporter BKN51_29980 ENOG4105R40 Glycine betaine carnitine choline BKN51_29985 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BKN51_29990 ENOG4105D7T ABC transporter BKN51_30000 ENOG4106N3A copper homeostasis protein cutc BKN51_30020 ENOG4105CFI type iii restriction protein res subunit BKN51_30040 ENOG4107TCW O-succinylbenzoate synthase BKN51_30050 ENOG4106SPC secreted protein BKN51_30055 ENOG4105F87 Dehydratase BKN51_30075 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BKN51_30085 ENOG4105VEQ Cold shock protein BKN51_30115 ENOG4105Y3U Transglycosylase-associated protein BKN51_30125 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme BKN51_30160 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BKN51_30170 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BKN51_30175 ENOG4105DWF phosphomethylpyrimidine kinase BKN51_30185 ENOG4105KVH Transcriptional regulator BKN51_30190 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BKN51_30215 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BKN51_30225 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BKN51_30230 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BKN51_30240 ENOG4105C7B Threonine dehydratase BKN51_30245 ENOG4105C57 major facilitator superfamily BKN51_30250 ENOG4105FDP GntR family transcriptional regulator BKN51_30255 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BKN51_30260 ENOG4105RD7 BadF BadG BcrA BcrD BKN51_30305 ENOG4105EV8 ectoine hydroxylase BKN51_30310 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BKN51_30320 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase BKN51_30355 ENOG41060H3 Protein of unknown function (DUF1049) BKN51_30365 ENOG4105FBA Phospholipase Carboxylesterase BKN51_30370 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BKN51_30380 ENOG4108ES0 acetoacetyl-CoA synthetase BKN51_30425 ENOG4105K4P CoA-binding domain protein BKN51_30435 ENOG4105DAA L-lactate BKN51_30455 ENOG4105CHP RNA polymerase BKN51_30460 ENOG4105GRZ Ycii-related protein BKN51_30470 ENOG4106NZI LysR family Transcriptional regulator BKN51_30475 ENOG4108MMM RNA Polymerase BKN51_30485 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein BKN51_30495 ENOG41082BM Transcriptional regulator, arsr family BKN51_30595 ENOG4105I6B RNA polymerase BKN51_30605 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BKN51_30610 ENOG41062GB lipoprotein lpqE BKN51_30615 ENOG4108VJ1 Transcriptional regulator (CarD family BKN51_30620 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BKN51_30625 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BKN51_30645 ENOG4105C8N cysteinyl-tRNA synthetase BKN51_30655 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BKN51_30675 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BKN51_30680 ENOG4108R86 Transcriptional regulator BKN51_30705 ENOG4107W7X Aldolase BKN51_30720 ENOG4106MP8 UPF0754 membrane protein BKN51_30725 ENOG4106MP8 UPF0754 membrane protein BKN51_30735 ENOG4105CC5 ABC transporter BKN51_30740 ENOG4105E0A ABC, transporter BKN51_30745 ENOG4105DSE periplasmic solute binding protein BKN51_30760 ENOG4105CEN a g-specific adenine glycosylase BKN51_30770 ENOG4105F27 Major Facilitator BKN51_30805 ENOG4105K63 Thioredoxin BKN51_30810 ENOG4105EBM Alpha Beta Hydrolase Fold protein BKN51_30830 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BKN51_30865 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BKN51_30875 ENOG4105CFG Acts as a chaperone (By similarity) BKN51_30880 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BKN51_30910 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BKN51_30915 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BKN51_30920 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BKN51_30925 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BKN51_30950 ENOG4105W1Y Transcriptional regulator BKN51_30965 ENOG4105EEI dihydropteroate synthase BKN51_30975 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BKN51_31005 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BKN51_31020 ENOG4105F0N pyrophosphate phospho-hydrolase BKN51_31025 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BKN51_31035 ENOG4108Z0R Transferase BKN51_31050 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BKN51_31055 ENOG4105CVA phosphate BKN51_31060 ENOG4107RN6 Monooxygenase BKN51_31065 ENOG4107RN6 Monooxygenase BKN51_31075 ENOG4108R85 Short chain dehydrogenase BKN51_31100 ENOG4107QRG dna polymerase iii BKN51_31105 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BKN51_31135 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BKN51_31160 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for BKN51_31165 ENOG4108I5C dEAD DEAH box helicase BKN51_31215 ENOG4105D17 glycoside hydrolase, family 3 domain protein BKN51_31220 ENOG4105EHZ conserved protein UCP016719 BKN51_31225 ENOG4107S1E Beta-lactamase BKN51_31230 ENOG4106KNT transcriptional regulator BKN51_31235 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BKN51_31240 ENOG4105D9G High-affinity BKN51_31250 ENOG4108A65 Transcriptional regulator BKN51_31290 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BKN51_31300 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BKN51_31305 ENOG41086D8 Transcriptional regulator BKN51_31345 ENOG4105DUX Transporter BKN51_31350 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BKN51_31360 ENOG4105D74 hydrolase BKN51_31365 ENOG4105VTS DnaJ-like, subfamily C BKN51_31380 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BKN51_31385 ENOG4105CSM endonuclease III BKN51_31415 ENOG41069FQ Metallo-beta-lactamase superfamily BKN51_31465 ENOG4105BZ4 penicillin-binding protein BKN51_31470 ENOG4105DIN metallophosphoesterase BKN51_31500 ENOG4105CVK Glutamate decarboxylase BKN51_31505 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction BKN51_31510 ENOG4108ZHJ Organic hydroperoxide resistance protein BKN51_31530 ENOG4105CH6 catalase BKN51_31545 ENOG4105E0Y RtcB Protein BKN51_31565 ENOG4105CFH Aspartokinase BKN51_31575 ENOG4105C57 major facilitator superfamily BKN51_31600 ENOG4105BZU Histidine kinase BKN51_31605 ENOG4107Z5C methylesterase BKN51_31630 ENOG4106NZI LysR family Transcriptional regulator BKN51_31635 ENOG4108594 Permease of the drug metabolite transporter BKN51_31665 ENOG4108JQ7 (ABC) transporter BKN51_31670 ENOG4105C3U ABC transporter BKN51_31675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_31680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN51_31685 ENOG4105DEF Extracellular solute-binding protein, family 5 BKN51_31700 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BKN51_31715 ENOG4105CKK Glycosyl transferase, family 2 BKN51_31720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BKN51_31725 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BKN51_31735 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase BKN51_31755 ENOG4105C7B Threonine dehydratase BKN51_31760 ENOG4105BZU Histidine kinase BKN51_31765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN51_31785 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_31815 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN51_31820 ENOG4107YB1 Trehalose corynomycolyl transferase BKN51_31825 ENOG4107YB1 Trehalose corynomycolyl transferase BKN51_31885 ENOG4105MXB limonene-12-epoxide hydrolase BKN51_31910 ENOG4108Z6B deaminase BKN51_31920 ENOG4105CH2 amidohydrolase BKN51_31925 ENOG41090KN UPF0303 protein BKN51_31955 ENOG4105EEM helicase BKN51_32000 ENOG4108UVJ appr-1-p processing domain protein BKN51_32015 ENOG4105D74 hydrolase BKN51_32020 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BKN51_32025 ENOG4105BZU Histidine kinase BKN51_32030 ENOG4108RCF TRANSCRIPTIONal BKN51_32035 ENOG4108UTW Plays a role in the regulation of phosphate uptake BKN51_32040 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BKN51_32045 ENOG4105E2Z phosphate ABC transporter (Permease BKN51_32055 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BKN51_32060 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BKN51_32065 ENOG4107NHD transcriptional regulator BKN51_32085 ENOG4105KHC sulfurtransferase BKN51_32090 ENOG4105PKJ carbohydrate binding BKN51_32095 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands BKN51_32105 ENOG4107R7A Allophanate hydrolase subunit 2 BKN51_32120 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BKN51_32135 ENOG4108TAC BKN51_32160 ENOG4105VT3 DNA binding domain protein, excisionase family BKN51_32180 ENOG4108YZN class I peptide chain release factor BKN51_32185 ENOG4105CXB phosphoribosylaminoimidazole synthetase BKN51_32250 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BKN51_32260 ENOG4105BZ1 (ABC) transporter BKN51_32265 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BKN51_32270 ENOG410839H phosphoribosylformylglycinamidine synthase BKN51_32300 ENOG4105E8R UPF0173 metal-dependent hydrolase BKN51_32305 ENOG4105DHF Membrane BKN51_32320 ENOG4105C8V SAICAR synthetase BKN51_32330 ENOG4105CDA abc transporter atp-binding protein BKN51_32335 ENOG4105EAD ABC transporter BKN51_32340 ENOG4105EAB amino acid AbC transporter BKN51_32345 ENOG4105EAB amino acid AbC transporter BKN51_32355 ENOG4105C83 adenylosuccinate lyase BKN51_32410 ENOG4105F9F transposase BKN51_32415 ENOG4108FKH Transglycosylase SLT domain BKN51_32450 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BKN51_32460 ENOG4105D2S major facilitator superfamily BKN51_32475 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BKN51_32490 ENOG4107QSI ABC, transporter BKN51_32500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_32505 ENOG4108JQ6 ABC transporter BKN51_32510 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BKN51_32520 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BKN51_32570 ENOG4105CPC Aldo Keto reductase BKN51_32575 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BKN51_32585 ENOG4107RN6 Monooxygenase BKN51_32610 ENOG4105CE4 GlcNAc 6-P deacetylase BKN51_32620 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN BKN51_32625 ENOG4105CQB FAD linked oxidase domain protein BKN51_32630 ENOG4105C57 major facilitator superfamily BKN51_32640 ENOG410905P Pyridoxamine 5-phosphate BKN51_32650 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_32655 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN BKN51_32665 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BKN51_32670 ENOG4107Z1W Fructose transport system kinase BKN51_32675 ENOG4108MGF sugar kinase BKN51_32680 ENOG4105C2J ABC transporter BKN51_32685 ENOG4105CNN ABC, transporter BKN51_32690 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator BKN51_32695 ENOG4105ETE Transcriptional regulator (LacI family BKN51_32700 ENOG4105ETE Transcriptional regulator (LacI family BKN51_32715 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BKN51_32720 ENOG4105C2N RNA methyltransferase TrmH family group 3 BKN51_32740 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_32770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BKN51_32845 ENOG4105KNI merR family transcriptional Regulator BKN51_32850 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BKN51_32855 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BKN51_32860 ENOG4105CFG Acts as a chaperone (By similarity) BKN51_32890 ENOG4108RFG Tetr family transcriptional regulator BKN51_32895 ENOG410814C multidrug resistance protein BKN51_32900 ENOG4105DF6 Fe-S oxidoreductase BKN51_32915 ENOG4105K4I Scp-like extracellular BKN51_32925 ENOG41061H0 Monooxygenase BKN51_32930 ENOG4105DHP deoxycytidine triphosphate deaminase BKN51_32990 ENOG4105GFG DUF218 domain BKN51_33030 ENOG4108MK9 spermidine N(1)-acetyltransferase BKN51_33040 ENOG4105CGH 5'-nucleotidase BKN51_33045 ENOG4108MXF Alpha Beta Hydrolase BKN51_33065 ENOG4108VCA G U mismatch-specific DNA glycosylase BKN51_33070 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_33075 ENOG4105CSU acyl-Coa dehydrogenase BKN51_33100 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BKN51_33160 ENOG4105CDA abc transporter atp-binding protein BKN51_33165 ENOG4105EAD ABC transporter BKN51_33170 ENOG4107R0W ABC transporter BKN51_33190 ENOG4105TVJ transport system, permease BKN51_33195 ENOG4105DQ5 transport system permease protein BKN51_33205 ENOG4105EBM Alpha Beta Hydrolase Fold protein BKN51_33210 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BKN51_33220 ENOG4105CPP Dehydrogenase, E1 component BKN51_33225 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 BKN51_33240 ENOG4105FS0 cytoplasmic membrane protein BKN51_33255 ENOG4108R86 Transcriptional regulator BKN51_33260 ENOG4108F01 MaoC domain protein BKN51_33265 ENOG4105CHR reductase BKN51_33270 ENOG4105CHU acetyl-coa acetyltransferase BKN51_33295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BKN51_33300 ENOG4107TXC Transcriptional regulator BKN51_33310 ENOG4105CJP fad dependent oxidoreductase BKN51_33315 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BKN51_33365 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BKN51_33375 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) BKN51_33390 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BKN51_33410 ENOG4105BZU Histidine kinase BKN51_33415 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_33425 ENOG4105CHR reductase BKN51_33445 ENOG4105DA5 (ABC) transporter BKN51_33460 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BKN51_33470 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BKN51_33480 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_33485 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BKN51_33490 ENOG4105EMU Dehydrogenase BKN51_33495 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids BKN51_33500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_33505 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein BKN51_33520 ENOG4105DXB Major Facilitator superfamily BKN51_33530 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 BKN51_33550 ENOG4105BZ4 penicillin-binding protein BKN51_33555 ENOG4105BZ4 penicillin-binding protein BKN51_33560 ENOG4105D9R oxidoreductase BKN51_33565 ENOG4105E2R ROK family BKN51_33610 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) BKN51_33620 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BKN51_33625 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BKN51_33655 ENOG4105CPC Aldo Keto reductase BKN51_33665 ENOG4105M4P Tetr family transcriptional regulator BKN51_33705 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BKN51_33715 ENOG4105E2R ROK family BKN51_33740 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_33765 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BKN51_33770 ENOG4108RVA ribokinase BKN51_33805 ENOG4105F6U Short-chain dehydrogenase reductase Sdr BKN51_33810 ENOG4105C8T Leucyl-tRNA synthetase BKN51_33880 ENOG4105DEN Luciferase family BKN51_33890 ENOG4108XG2 Histidine kinase BKN51_33900 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BKN51_33945 ENOG4105C3M thioredoxin reductase BKN51_33950 ENOG4108E1C hydrolase BKN51_33965 ENOG4105CPF Cell wall formation (By similarity) BKN51_33980 ENOG4107QJE Chromosome Partitioning Protein BKN51_33985 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BKN51_33995 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BKN51_34010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BKN51_34015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BKN51_34020 ENOG4108J5G 6-phosphogluconate dehydrogenase BKN51_34025 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BKN51_34035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN51_34040 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN51_34090 ENOG4108Z4X TRANSCRIPTIONal BKN51_34100 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_34105 ENOG4105BZU Histidine kinase BKN51_34160 ENOG4107ZXI Rhomboid family BKN51_34180 ENOG4108U4N (sortase) family BKN51_34185 ENOG4108M8W Monooxygenase BKN51_34200 ENOG4105CJ1 ABC, transporter BKN51_34225 ENOG4105CIG ABC transporter BKN51_34250 ENOG4107TPY serine threonine protein kinase BKN51_34255 ENOG4105CJN penicillin-binding protein BKN51_34270 ENOG4105HZM Fha domain containing protein BKN51_34275 ENOG4105TV9 FHA Domain-Containing protein BKN51_34295 ENOG4105C28 cystathionine BKN51_34320 ENOG4108QBF Transcriptional regulator BKN51_34325 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BKN51_34335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN51_34345 ENOG4108JQ7 (ABC) transporter BKN51_34350 ENOG4105C26 Dehydrogenase BKN51_34360 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_34375 ENOG4105CI0 Citrate lyase BKN51_34400 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BKN51_34450 ENOG4105F0K SARP family transcriptional regulator BKN51_34470 ENOG4108T5E Copper resistance protein BKN51_34485 ENOG4105E90 ABC transporter BKN51_34490 ENOG4108IJ8 ABC transporter BKN51_34495 ENOG4105E90 ABC transporter BKN51_34500 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system BKN51_34520 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN51_34530 ENOG4105C6Y Udp-glucose 6-dehydrogenase BKN51_34535 ENOG4108IG5 Transcriptional regulator BKN51_34580 ENOG4105BZU Histidine kinase BKN51_34585 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_34605 ENOG4108PQP glycosyl transferase group 1 BKN51_34610 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BKN51_34685 ENOG4108HRK Histidine kinase BKN51_34700 ENOG4105DY9 regulatoR BKN51_34710 ENOG4107QN1 sodium solute BKN51_34720 ENOG4107QN1 sodium solute BKN51_34725 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BKN51_34765 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN51_34780 ENOG4105CEU Arginine dihydrolase BKN51_34845 ENOG4105C4M (Ubiquinol oxidase) subunit I BKN51_34850 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BKN51_34855 ENOG4108JJ9 ABC, transporter BKN51_34920 ENOG4105KBK Zinc finger, swim domain protein BKN51_34940 ENOG4105CS9 pantothenic acid kinase BKN51_34955 ENOG4108RH7 phosphoglycerate mutase BKN51_34990 ENOG4106032 Glutathionylspermidine synthase BKN51_34995 ENOG4105P3N Membrane BKN51_35000 ENOG4108J2P Alpha beta hydrolase fold BKN51_35005 ENOG4105C8Y Acetylornithine aminotransferase BKN51_35010 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BKN51_35020 ENOG4105D5U fad dependent oxidoreductase BKN51_35025 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BKN51_35035 ENOG4105C57 major facilitator superfamily BKN51_35060 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BKN51_35070 ENOG4105JNK Glycosyl transferase (Group 1 BKN51_35140 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BKN51_35155 ENOG4105CHR reductase BKN51_35205 ENOG4108KP7 hydrolase BKN51_35210 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BKN51_35230 ENOG4106YN8 Prenyltransferase BKN51_35270 ENOG4108RG3 short-chain dehydrogenase reductase BKN51_35275 ENOG4105IQ5 FAD linked oxidase domain protein BKN51_35285 ENOG410602S Transferase BKN51_35320 ENOG4108MKI Glycosyl transferase, family 2 BKN51_35340 ENOG4105CNA YD repeat protein BKN51_35350 ENOG4105CIR epoxide hydrolase BKN51_35355 ENOG4108VC7 Protein of unknown function (DUF2587) BKN51_35365 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BKN51_35370 ENOG4105IIU Aminopeptidase BKN51_35385 ENOG4105CHP RNA polymerase BKN51_35390 ENOG4105GRZ Ycii-related protein BKN51_35445 ENOG4105BZU Histidine kinase BKN51_35450 ENOG4105CNA YD repeat protein BKN51_35480 ENOG4107SM8 Adenylate Guanylate cyclase BKN51_35485 ENOG4106T9R serine protease BKN51_35490 ENOG4105KF0 sporulation and cell division protein, SsgA BKN51_35520 ENOG41073TP transcriptional regulator BKN51_35535 ENOG4105CIH Imidazole acetol-phosphate transaminase BKN51_35560 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BKN51_35565 ENOG4105CRK lysyL-tRNA synthetase BKN51_35610 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BKN51_35630 ENOG41082JN Transcriptional regulator BKN51_35635 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BKN51_35685 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BKN51_35715 ENOG4105DIM ABC transporter BKN51_35720 ENOG4105CIG ABC transporter BKN51_35760 ENOG4105I1F Resistance protein BKN51_35785 ENOG4105E2B Taurine dioxygenase BKN51_35795 ENOG4105EVN Prephenate dehydrogenase BKN51_35800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BKN51_35815 ENOG4105K56 Transcriptional regulator BKN51_35850 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase BKN51_35955 ENOG4105VEQ Cold shock protein BKN51_35965 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_35970 ENOG4105BZU Histidine kinase BKN51_36005 ENOG4105CJA serine threonine protein kinase BKN51_36040 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_36045 ENOG4105BZU Histidine kinase BKN51_36055 ENOG4107RR1 TRANSCRIPTIONal BKN51_36065 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_36075 ENOG4105CT1 (ABC) transporter BKN51_36100 ENOG4107Q25 Serine Threonine protein kinase BKN51_36110 ENOG4105CSH Transporter BKN51_36120 ENOG4105NAF rna polymerase sigma factor BKN51_36135 ENOG4105VEQ Cold shock protein BKN51_36170 ENOG4105DJY efflux transporter, rnd family, mfp subunit BKN51_36175 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_36180 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BKN51_36200 ENOG4105BZU Histidine kinase BKN51_36210 ENOG4105C2W permease BKN51_36225 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BKN51_36290 ENOG4108RFG Tetr family transcriptional regulator BKN51_36325 ENOG4108VW9 Membrane BKN51_36330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BKN51_36350 ENOG4106BRA Membrane BKN51_36370 ENOG4105CAT Cytidine monophosphate kinase BKN51_36375 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BKN51_36385 ENOG4105V9F hemagglutinin BKN51_36390 ENOG4105TT9 Protein of unknown function (DUF2516) BKN51_36400 ENOG4105C84 Histidine ammonia-lyase BKN51_36415 ENOG4105E90 ABC transporter BKN51_36430 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BKN51_36460 ENOG4107R4N Cell wall formation (By similarity) BKN51_36475 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BKN51_36490 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BKN51_36505 ENOG4105BZU Histidine kinase BKN51_36520 ENOG41063NU Membrane BKN51_36535 ENOG4105II7 pyrroline-5-carboxylate reductase BKN51_36555 ENOG4108RXW HAD-superfamily subfamily IB hydrolase BKN51_36570 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_36580 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) BKN51_36585 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BKN51_36590 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BKN51_36595 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BKN51_36600 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BKN51_36610 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BKN51_36640 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BKN51_36645 ENOG4108RH7 phosphoglycerate mutase BKN51_36650 ENOG4107QX9 Thiol disulfide interChange protein BKN51_36660 ENOG4107QIV Cytochrome c biogenesis protein BKN51_36670 ENOG4105CRE cytochrome C BKN51_36690 ENOG4105F7P transcriptional regulator AsnC family BKN51_36715 ENOG4107SIQ Naphthoate synthase BKN51_36720 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BKN51_36745 ENOG4105ECY inositol monophosphatase BKN51_36755 ENOG4108MJN Glycosyl Transferase BKN51_36780 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BKN51_36785 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BKN51_36790 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BKN51_36805 ENOG4108IEH NADH dehydrogenase subunit g BKN51_36810 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BKN51_36815 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BKN51_36820 ENOG41087XN oxidoreductase BKN51_36825 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BKN51_36830 ENOG4105D65 subunit l BKN51_36840 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BKN51_36890 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BKN51_36930 ENOG4105DQU oxidoreductase, subunit beta BKN51_36935 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BKN51_36945 ENOG4105F7P transcriptional regulator AsnC family BKN51_36950 ENOG4105CIK Amidinotransferase BKN51_36975 ENOG4105C6Y Udp-glucose 6-dehydrogenase BKN51_36995 ENOG4105CAQ asparagine synthetase BKN51_37000 ENOG4107RRD Dehydrogenase BKN51_37045 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BKN51_37050 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BKN51_37060 ENOG4105K64 Glycosyl transferase, family 2 BKN51_37070 ENOG4105EQQ protein containing aminopeptidase domain BKN51_37085 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BKN51_37115 ENOG4105D0M Protease HtpX homolog BKN51_37125 ENOG4105CPU Monooxygenase BKN51_37145 ENOG4108VPT UPF0234 protein BKN51_37165 ENOG4105NAE bifunctional deaminase-reductase domain protein BKN51_37190 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BKN51_37195 ENOG4105NPE arsR family transcriptional regulator BKN51_37200 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_37205 ENOG4105BZU Histidine kinase BKN51_37210 ENOG4107T5V SNARE associated Golgi BKN51_37220 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BKN51_37235 ENOG4105BZU Histidine kinase BKN51_37250 ENOG4105WDJ 50S ribosomal protein L33 BKN51_37255 ENOG410900P UPF0336 protein BKN51_37265 ENOG4108TCJ secreted hydrolase BKN51_37275 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BKN51_37300 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BKN51_37305 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BKN51_37310 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) BKN51_37320 ENOG4108VZM 50s ribosomal protein L10 BKN51_37325 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BKN51_37390 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BKN51_37395 ENOG4105FQP Beta-lactamase BKN51_37400 ENOG4108UQS dipeptidase BKN51_37455 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BKN51_37460 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BKN51_37465 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BKN51_37470 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BKN51_37480 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BKN51_37485 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BKN51_37490 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BKN51_37495 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BKN51_37500 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BKN51_37505 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BKN51_37510 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BKN51_37515 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BKN51_37520 ENOG41082SA 50s ribosomal protein l29 BKN51_37525 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BKN51_37530 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BKN51_37535 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BKN51_37540 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BKN51_37545 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BKN51_37550 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BKN51_37555 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BKN51_37560 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BKN51_37565 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BKN51_37570 ENOG410849U 50S ribosomal protein L30 BKN51_37575 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BKN51_37585 ENOG4108NIW Leucine export protein LeuE BKN51_37595 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BKN51_37610 ENOG41067V7 50S ribosomal protein L36 BKN51_37615 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BKN51_37625 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BKN51_37630 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BKN51_37635 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BKN51_37640 ENOG4108ZT0 50S ribosomal protein l17 BKN51_37645 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BKN51_37680 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_37690 ENOG4105EC2 ftsk spoIIIe BKN51_37695 ENOG4105CFG Acts as a chaperone (By similarity) BKN51_37725 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BKN51_37735 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BKN51_37760 ENOG4107RCI amp-dependent synthetase and ligase BKN51_37765 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BKN51_37800 ENOG4107EDW L-fucose operon activator BKN51_37810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BKN51_37815 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BKN51_37820 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 BKN51_37825 ENOG4108097 ATP-binding protein BKN51_37835 ENOG4105D8K carboxyl transferase BKN51_37840 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_37850 ENOG41080E2 ribosomal-protein-alanine acetyltransferase BKN51_37855 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BKN51_37890 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BKN51_37895 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BKN51_37900 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BKN51_37905 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BKN51_37935 ENOG4108VT4 BKN51_37950 ENOG4107QVP Dehydrogenase BKN51_37970 ENOG4105DNP FAD linked oxidase domain protein BKN51_37990 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BKN51_38030 ENOG4105C5Q Transcriptional regulator BKN51_38080 ENOG4105DR5 peptidase BKN51_38095 ENOG4105CMV Succinyl-CoA synthetase subunit beta BKN51_38120 ENOG4105DC1 bifunctional purine biosynthesis protein purh BKN51_38165 ENOG4105C0B DNA polymerase III (alpha subunit) BKN51_38180 ENOG4107RRE RNA-directed DNA polymerase BKN51_38200 ENOG4105F27 Major Facilitator BKN51_38205 ENOG4105YVS arsR family transcriptional regulator BKN51_38210 ENOG4108RWP Major Facilitator Superfamily protein BKN51_38245 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BKN51_38255 ENOG4108FN7 Aldo keto reductase BKN51_38265 ENOG4105EW9 transcriptional regulator AsnC family BKN51_38275 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BKN51_38300 ENOG4108RQ5 Beta-lactamase domain-containing protein BKN51_38355 ENOG4105C31 Tryptophanyl-tRNA synthetase BKN51_38360 ENOG4107H3J ribonuclease BKN51_38370 ENOG4105DZ1 carboxypeptidase BKN51_38380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN51_38395 ENOG4105E33 succinate dehydrogenase BKN51_38415 ENOG4105DIH basic membrane BKN51_38420 ENOG4108JQ9 ABC transporter BKN51_38450 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BKN51_38455 ENOG4105E5T Major Facilitator Superfamily BKN51_38480 ENOG4105KVH Transcriptional regulator BKN51_38490 ENOG4105CPQ Dehydrogenase BKN51_38525 ENOG4105C26 Dehydrogenase BKN51_38530 ENOG4105C26 Dehydrogenase BKN51_38535 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BKN51_38540 ENOG4107R6D beta-lactam binding protein AmpH BKN51_38555 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BKN51_38580 ENOG4105CPC Aldo Keto reductase BKN51_38585 ENOG4107SET aldo keto reductase BKN51_38625 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain BKN51_38680 ENOG4107RM1 amidohydrolase BKN51_38720 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BKN51_38725 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BKN51_38730 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BKN51_38755 ENOG4108JIK carboxylase BKN51_38770 ENOG4107QJT sodium dicarboxylate symporter BKN51_38775 ENOG4107WR6 Maf-like protein BKN51_38820 ENOG4105D8K carboxyl transferase BKN51_38830 ENOG4105BZU Histidine kinase BKN51_38840 ENOG4108WS4 fmn reductase BKN51_38845 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BKN51_38850 ENOG4105ECQ AraC Family Transcriptional Regulator BKN51_38860 ENOG41082BM Transcriptional regulator, arsr family BKN51_38870 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BKN51_38915 ENOG4105K4H Nlp p60 protein BKN51_38920 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BKN51_38930 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BKN51_38945 ENOG4107TK4 histidinol-phosphate phosphatase BKN51_38955 ENOG4105BZU Histidine kinase BKN51_38970 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_38985 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_39015 ENOG4108VJY integral membrane protein BKN51_39025 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BKN51_39030 ENOG4105CEY Amp-dependent synthetase and ligase BKN51_39050 ENOG4108SB3 DoxX Family BKN51_39060 ENOG4107TB5 TRANSCRIPTIONal BKN51_39065 ENOG4107TB5 TRANSCRIPTIONal BKN51_39080 ENOG4108TJN glycosyl transferase group 1 BKN51_39095 ENOG4105E2K Glycosyl transferase (Group 1 BKN51_39135 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BKN51_39150 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) BKN51_39155 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase BKN51_39170 ENOG4108Z4U Ferredoxin BKN51_39185 ENOG4107SCK Monooxygenase BKN51_39195 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) BKN51_39205 ENOG4107R4C succinyl-diaminopimelate desuccinylase BKN51_39250 ENOG4105E08 Glycoside hydrolase, family 9 BKN51_39260 ENOG4108URH decarboxylase BKN51_39270 ENOG4105C3Q Glycosyl transferase, family 2 BKN51_39280 ENOG4108JJ9 ABC, transporter BKN51_39285 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BKN51_39290 ENOG4105C4M (Ubiquinol oxidase) subunit I BKN51_39325 ENOG4108R3E Dna-3-methyladenine glycosylase i BKN51_39335 ENOG4108UKI Enoyl-CoA hydratase BKN51_39345 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BKN51_39350 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BKN51_39355 ENOG4105DDW LysR family Transcriptional regulator BKN51_39360 ENOG4105D94 Major Facilitator Superfamily BKN51_39375 ENOG4106684 BKN51_39385 ENOG4105C0H protease BKN51_39390 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BKN51_39405 ENOG4105CJW magnesium transporter BKN51_39440 ENOG4105C1G acyl-Coa dehydrogenase BKN51_39485 ENOG4108SGK Tetr family transcriptional regulator BKN51_39505 ENOG4105D7N magnesium and cobalt transport protein CorA BKN51_39530 ENOG4105DB7 PHP domain protein BKN51_39535 ENOG41081FY multiple antibiotic resistance (MarC)-related BKN51_39560 ENOG4105C1J atp-dependent rna helicase BKN51_39595 ENOG410832A alpha/beta hydrolase fold BKN51_39610 ENOG4108YIQ Alpha beta hydrolase BKN51_39635 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BKN51_39645 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BKN51_39650 ENOG4108IFG nitrite reductase, (NAD(P)H) BKN51_39655 ENOG4105DQQ Major facilitator superfamily MFS_1 BKN51_39660 ENOG4107QZF nitrite reductase NADPH large subunit BKN51_39665 ENOG4107QZF nitrite reductase NADPH large subunit BKN51_39670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN51_39685 ENOG4105D29 Helix-turn-helix type 11 domain protein BKN51_39695 ENOG4108XG2 Histidine kinase BKN51_39750 ENOG4108WQ6 secreted protein BKN51_39755 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BKN51_39810 ENOG4105C1V Peptidase, M16 BKN51_39830 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BKN51_39835 ENOG4105DRS transport system, permease BKN51_39840 ENOG4105F8D glycoside hydrolase family 4 BKN51_39855 ENOG4105NPE arsR family transcriptional regulator BKN51_39860 ENOG4105C6Z Gluconate BKN51_39865 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BKN51_39875 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BKN51_39905 ENOG4105EGD dinuclear metal center protein, YbgI family BKN51_39915 ENOG4105CVJ phosphoglycerate mutase BKN51_39925 ENOG4105FBW Monooxygenase BKN51_40020 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) BKN51_40025 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BKN51_40030 ENOG4105C26 Dehydrogenase BKN51_40045 ENOG4105C8Q Methyl-accepting chemotaxis BKN51_40055 ENOG4105C26 Dehydrogenase BKN51_40060 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BKN51_40065 ENOG4107TYH extracellular solute-binding protein family 1 BKN51_40070 ENOG4105D81 ABC transporter, permease BKN51_40075 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component BKN51_40085 ENOG4108HGY Proline imino-peptidase BKN51_40095 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BKN51_40100 ENOG4105CRK lysyL-tRNA synthetase BKN51_40120 ENOG4105C4K Nad synthetase BKN51_40125 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BKN51_40150 ENOG4105C5F glutamine synthetase BKN51_40155 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_40185 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BKN51_40195 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BKN51_40205 ENOG4105C5F glutamine synthetase BKN51_40235 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BKN51_40255 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BKN51_40275 ENOG41063PX domain protein BKN51_40285 ENOG4105DJZ UPF0182 protein BKN51_40315 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BKN51_40320 ENOG4105CAK Cell division ATP-binding protein ftsE BKN51_40325 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) BKN51_40330 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BKN51_40350 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_40355 ENOG4105ENE Histidine kinase BKN51_40375 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BKN51_40385 ENOG4105C84 Histidine ammonia-lyase BKN51_40390 ENOG4105CGP Urocanate hydratase BKN51_40400 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BKN51_40405 ENOG4105CI2 imidazolone-5-propionate hydrolase BKN51_40420 ENOG4105BZU Histidine kinase BKN51_40425 ENOG4105WH1 Two component transcriptional regulator luxr family BKN51_40430 ENOG41061H0 Monooxygenase BKN51_40460 ENOG4105CQ7 ATP-dependent helicase BKN51_40465 ENOG4107UBR Extracellular solute-binding protein family 3 BKN51_40480 ENOG4107RSM transcriptional regulator BKN51_40485 ENOG4107QK4 glycoside hydrolase, family 3 domain protein BKN51_40515 ENOG410900P UPF0336 protein BKN51_40520 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BKN51_40525 ENOG4105C1G acyl-Coa dehydrogenase BKN51_40530 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BKN51_40550 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN51_40555 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN51_40575 ENOG4108UZX fmn reductase BKN51_40590 ENOG4107S5I aldo keto reductase BKN51_40630 ENOG4105DQE DNA ligase BKN51_40635 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase BKN51_40690 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BKN51_40705 ENOG4107QJN gtp cyclohydrolase ii BKN51_40715 ENOG4105ECY inositol monophosphatase BKN51_40720 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BKN51_40730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BKN51_40740 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BKN51_40745 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BKN51_40775 ENOG41060BG Tetr family transcriptional regulator BKN51_40790 ENOG4108222 arsenate reductase BKN51_40810 ENOG4105CPC Aldo Keto reductase BKN51_40815 ENOG4105CIR epoxide hydrolase BKN51_40840 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BKN51_40845 ENOG4105S6R Iron-hydroxamate transporter permease subunit BKN51_40850 ENOG4105J76 Periplasmic binding protein BKN51_40855 ENOG4105E0A ABC, transporter BKN51_40870 ENOG4105DIK (ABC) transporter BKN51_40875 ENOG4105DSE periplasmic solute binding protein BKN51_40880 ENOG4105DF6 Fe-S oxidoreductase BKN51_40900 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BKN51_40975 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BKN51_40980 ENOG4108MRH transcriptional regulatory protein BKN51_40985 ENOG4105CR4 methylisocitrate lyase BKN51_40995 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN51_41000 ENOG4105E2R ROK family BKN51_41010 ENOG4105C2J ABC transporter BKN51_41015 ENOG4105CNN ABC, transporter BKN51_41090 ENOG4108KPJ rna polymerase sigma factor BKN51_41100 ENOG4105C94 Transporter BKN51_41105 ENOG4105ECQ AraC Family Transcriptional Regulator BKN51_41135 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BKN51_41150 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BKN51_41155 ENOG4108VJY integral membrane protein BKN51_41160 ENOG4108CIP transcriptional regulator BKN51_41180 ENOG4108IG5 Transcriptional regulator BKN51_41185 ENOG4105NAE bifunctional deaminase-reductase domain protein BKN51_41200 ENOG4105F27 Major Facilitator BKN51_41205 ENOG4105HHS UPF0256 protein BKN51_41250 ENOG4105EYW Ion transport protein BKN51_41280 ENOG4108KTG Membrane protein, drug metabolite transporter BKN51_41365 ENOG41063TF transcriptional regulator (AraC BKN51_41395 ENOG4105CPF Cell wall formation (By similarity) BKN51_41400 ENOG4108UQS dipeptidase BKN51_41415 ENOG4105BZ1 (ABC) transporter BKN51_41490 ENOG4105EDW glycosyl transferase, family 39 BKN51_41575 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BKN51_41580 ENOG4105KVH Transcriptional regulator BKN51_41595 ENOG4107S5I aldo keto reductase BKN51_41610 ENOG4105KVH Transcriptional regulator BKN51_41635 ENOG4108HMN Caspase domain BKN51_41645 ENOG4105DZC cytosine deaminase BKN51_41725 ENOG4105KVH Transcriptional regulator BKN51_41730 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN51_41745 ENOG4105CIR epoxide hydrolase BKN51_41750 ENOG4105CF7 AraC family transcriptional regulator BKN51_41755 ENOG4105CPC Aldo Keto reductase BKN51_41760 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN51_41830 ENOG4108HUF Transporter BKN51_41835 ENOG4105DQ5 transport system permease protein BKN51_41840 ENOG4105TVJ transport system, permease BKN51_41845 ENOG4105BZ1 (ABC) transporter BKN51_41850 ENOG4105BZ1 (ABC) transporter BKN51_41915 ENOG4105EGE secreted protein BKN51_41990 ENOG4108Z6Z Transcriptional regulator BKN51_42035 ENOG4105E89 ABC transporter BKN51_42040 ENOG4105E5Q amino acid AbC transporter BKN51_42060 ENOG4106JDR secreted BKN51_42065 ENOG4108M15 ABC transporter BKN51_42090 ENOG4105C6F GntR Family Transcriptional Regulator BKN51_42095 ENOG4105CNN ABC, transporter BKN51_42100 ENOG4105C2J ABC transporter BKN51_42120 ENOG4105ESN nucleotide-binding protein BKN51_42145 ENOG4105F9F transposase BKN51_42160 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BKN51_42170 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BKN51_42175 ENOG4105DGI Alkaline phosphatase BKN51_42185 ENOG4105F5H Glycosyl Hydrolase Family 88 BKN51_42190 ENOG4105EEI dihydropteroate synthase BKN51_42195 ENOG4108XG2 Histidine kinase BKN51_42205 ENOG4108IY8 ABC, transporter BKN51_42210 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BKN51_42215 ENOG4108MES Periplasmic binding protein BKN51_42225 ENOG4105C1J atp-dependent rna helicase BKN51_42240 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)