locus-tag	class	description
HUW46_00001	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUW46_00002	COG1120	ATPase activity
HUW46_00013	COG1073	alpha beta
HUW46_00018	COG3119	arylsulfatase activity
HUW46_00027	COG2124	cytochrome p450
HUW46_00033	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW46_00034	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW46_00035	COG1316	TRANSCRIPTIONal
HUW46_00038	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW46_00039	COG0367	asparagine synthase
HUW46_00040	COG1309	transcriptional regulator
HUW46_00041	COG2267	carboxylic ester hydrolase activity
HUW46_00046	COG3383	formate dehydrogenase (NAD+) activity
HUW46_00047	COG3979	chitinase
HUW46_00051	COG1309	transcriptional regulator
HUW46_00052	COG0702	epimerase
HUW46_00064	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW46_00068	COG0477	Major facilitator Superfamily
HUW46_00069	COG0778	Nitroreductase
HUW46_00073	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_00076	COG0656	L-ascorbic acid biosynthetic process
HUW46_00077	COG0745	RESPONSE REGULATOR receiver
HUW46_00078	COG4251	negative regulation of phosphorylation
HUW46_00079	COG0784	Response regulator, receiver
HUW46_00081	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUW46_00082	COG1725	Transcriptional regulator
HUW46_00083	COG3629	intracellular signal transduction
HUW46_00083	COG3903	Transcriptional regulator
HUW46_00084	COG1280	lysine exporter protein (LysE YggA)
HUW46_00093	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW46_00093	COG2146	nitrite reductase [NAD(P)H] activity
HUW46_00094	COG2146	nitrite reductase [NAD(P)H] activity
HUW46_00094	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW46_00095	COG2223	nitrite transmembrane transporter activity
HUW46_00096	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW46_00097	COG0243	molybdopterin cofactor binding
HUW46_00098	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW46_00106	COG0436	Aminotransferase
HUW46_00115	COG2197	response regulator
HUW46_00116	COG4585	Histidine kinase
HUW46_00122	COG3973	AAA domain
HUW46_00133	COG0514	ATP-dependent DNA helicase (RecQ)
HUW46_00139	COG1278	Cold shock
HUW46_00141	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00142	COG1929	Belongs to the glycerate kinase type-1 family
HUW46_00143	COG1522	sequence-specific DNA binding
HUW46_00145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_00147	COG3250	beta-galactosidase activity
HUW46_00149	COG0542	response to heat
HUW46_00155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW46_00156	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUW46_00158	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00161	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW46_00163	COG0681	Belongs to the peptidase S26 family
HUW46_00165	COG0646	methionine synthase
HUW46_00165	COG1410	methionine synthase
HUW46_00166	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_00167	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_00170	COG1960	acyl-CoA dehydrogenase activity
HUW46_00173	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_00178	COG0477	Major facilitator Superfamily
HUW46_00185	COG1104	cysteine desulfurase activity
HUW46_00188	COG2226	methyltransferase
HUW46_00190	COG2072	flavoprotein involved in K transport
HUW46_00192	COG4941	Belongs to the sigma-70 factor family
HUW46_00201	COG0702	epimerase
HUW46_00205	COG4977	sequence-specific DNA binding
HUW46_00211	COG5650	phosphatidylinositol metabolic process
HUW46_00212	COG0174	glutamine synthetase
HUW46_00219	COG2326	polyphosphate kinase activity
HUW46_00220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW46_00225	COG1595	DNA-templated transcription, initiation
HUW46_00234	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW46_00237	COG1793	dna ligase
HUW46_00244	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW46_00245	COG0506	proline dehydrogenase activity
HUW46_00246	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_00247	COG2508	Transcriptional regulator
HUW46_00247	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HUW46_00250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_00255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW46_00257	COG3220	belongs to the UPF0276 family
HUW46_00259	COG3253	May function as heme-dependent peroxidase
HUW46_00260	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUW46_00261	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUW46_00263	COG0693	protein deglycase activity
HUW46_00264	COG2197	response regulator
HUW46_00266	COG0183	Belongs to the thiolase family
HUW46_00267	COG1024	Enoyl-CoA hydratase
HUW46_00267	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_00268	COG3250	beta-galactosidase activity
HUW46_00269	COG0656	L-ascorbic acid biosynthetic process
HUW46_00270	COG2205	protein histidine kinase activity
HUW46_00271	COG0745	RESPONSE REGULATOR receiver
HUW46_00273	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW46_00276	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_00278	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_00279	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUW46_00280	COG0346	lactoylglutathione lyase activity
HUW46_00281	COG2267	carboxylic ester hydrolase activity
HUW46_00282	COG1960	acyl-CoA dehydrogenase activity
HUW46_00284	COG1053	succinate dehydrogenase
HUW46_00287	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW46_00288	COG2030	dehydratase
HUW46_00289	COG2070	2-Nitropropane dioxygenase
HUW46_00291	COG1024	Enoyl-CoA hydratase
HUW46_00293	COG2226	methyltransferase
HUW46_00294	COG1309	transcriptional regulator
HUW46_00300	COG2124	cytochrome p450
HUW46_00301	COG0183	Belongs to the thiolase family
HUW46_00304	COG1733	regulation of RNA biosynthetic process
HUW46_00305	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00306	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00307	COG1024	Enoyl-CoA hydratase
HUW46_00313	COG0372	Belongs to the citrate synthase family
HUW46_00314	COG0372	Belongs to the citrate synthase family
HUW46_00320	COG0183	Belongs to the thiolase family
HUW46_00321	COG1309	transcriptional regulator
HUW46_00322	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00323	COG1960	acyl-CoA dehydrogenase activity
HUW46_00324	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_00325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUW46_00326	COG1960	acyl-CoA dehydrogenase activity
HUW46_00327	COG1960	acyl-CoA dehydrogenase activity
HUW46_00328	COG1960	acyl-CoA dehydrogenase activity
HUW46_00331	COG0745	RESPONSE REGULATOR receiver
HUW46_00332	COG2205	protein histidine kinase activity
HUW46_00335	COG0477	Major facilitator Superfamily
HUW46_00344	COG1122	ATPase activity
HUW46_00347	COG0310	cobalt ion transport
HUW46_00353	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_00360	COG2828	Protein conserved in bacteria
HUW46_00367	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUW46_00369	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUW46_00373	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUW46_00375	COG0477	Major facilitator Superfamily
HUW46_00376	COG0640	Transcriptional regulator
HUW46_00381	COG1799	cell septum assembly
HUW46_00384	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUW46_00386	COG1595	DNA-templated transcription, initiation
HUW46_00389	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUW46_00391	COG1846	Transcriptional regulator
HUW46_00395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUW46_00396	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW46_00397	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW46_00399	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUW46_00400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW46_00403	COG0768	penicillin binding
HUW46_00405	COG0275	rRNA processing
HUW46_00406	COG2001	Belongs to the MraZ family
HUW46_00411	COG0714	Associated with various cellular activities
HUW46_00413	COG1305	Transglutaminase-like
HUW46_00415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW46_00417	COG1192	Involved in chromosome partitioning
HUW46_00418	COG0455	bacterial-type flagellum organization
HUW46_00419	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW46_00421	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUW46_00423	COG0167	dihydroorotate dehydrogenase activity
HUW46_00425	COG1842	Phage shock protein A
HUW46_00426	COG1396	sequence-specific DNA binding
HUW46_00427	COG1546	Belongs to the CinA family
HUW46_00427	COG1058	Belongs to the CinA family
HUW46_00429	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW46_00430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUW46_00443	COG1674	ftsk spoiiie
HUW46_00445	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUW46_00449	COG1113	amino acid transport
HUW46_00453	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUW46_00454	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW46_00455	COG0515	serine threonine protein kinase
HUW46_00461	COG1278	Cold shock
HUW46_00463	COG1672	PFAM Archaeal ATPase
HUW46_00463	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW46_00465	COG0477	Major facilitator Superfamily
HUW46_00466	COG3214	Protein conserved in bacteria
HUW46_00473	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW46_00474	COG0612	Peptidase, M16
HUW46_00475	COG1185	polyribonucleotide nucleotidyltransferase activity
HUW46_00476	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUW46_00480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUW46_00483	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW46_00486	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUW46_00488	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW46_00488	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW46_00490	COG0779	Required for maturation of 30S ribosomal subunits
HUW46_00496	COG4585	Histidine kinase
HUW46_00506	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUW46_00507	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUW46_00511	COG0494	nUDIX hydrolase
HUW46_00512	COG0504	CTP synthase activity
HUW46_00513	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUW46_00514	COG1802	Transcriptional regulator
HUW46_00515	COG1953	Uracil, thiamine, allantoin
HUW46_00520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUW46_00523	COG0647	UMP catabolic process
HUW46_00528	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUW46_00529	COG2094	Belongs to the DNA glycosylase MPG family
HUW46_00532	COG0165	Argininosuccinate lyase
HUW46_00533	COG0137	argininosuccinate synthase activity
HUW46_00534	COG1438	arginine binding
HUW46_00535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW46_00536	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW46_00537	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUW46_00538	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUW46_00539	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUW46_00544	COG0072	phenylalanine-tRNA ligase activity
HUW46_00544	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW46_00545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW46_00546	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW46_00547	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUW46_00548	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUW46_00552	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUW46_00553	COG0251	oxidation-reduction process
HUW46_00557	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUW46_00558	COG2610	gluconate transmembrane transporter activity
HUW46_00559	COG2706	6-phosphogluconolactonase activity
HUW46_00561	COG1175	transmembrane transport
HUW46_00562	COG0395	ABC-type sugar transport system, permease component
HUW46_00563	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW46_00565	COG4565	transcriptional regulatory protein
HUW46_00566	COG3290	protein histidine kinase activity
HUW46_00568	COG1301	dicarboxylic acid transport
HUW46_00573	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_00576	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00577	COG0583	DNA-binding transcription factor activity
HUW46_00607	COG1285	pathogenesis
HUW46_00610	COG1113	amino acid transport
HUW46_00611	COG1070	Carbohydrate kinase
HUW46_00612	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HUW46_00613	COG1609	Transcriptional regulator
HUW46_00614	COG1879	ABC-type sugar transport system periplasmic component
HUW46_00615	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW46_00616	COG1129	ABC transporter
HUW46_00619	COG0823	Involved in the tonB-independent uptake of proteins
HUW46_00619	COG1506	peptidase
HUW46_00619	COG4946	Tricorn protease homolog
HUW46_00621	COG1131	(ABC) transporter
HUW46_00625	COG1024	Enoyl-CoA hydratase
HUW46_00629	COG2197	response regulator
HUW46_00630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_00637	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW46_00638	COG0237	dephospho-CoA kinase activity
HUW46_00638	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUW46_00641	COG2315	Protein conserved in bacteria
HUW46_00642	COG1960	acyl-CoA dehydrogenase activity
HUW46_00643	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_00645	COG1024	Enoyl-CoA hydratase
HUW46_00646	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_00650	COG0583	DNA-binding transcription factor activity
HUW46_00651	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUW46_00653	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW46_00653	COG2755	lipolytic protein G-D-S-L family
HUW46_00654	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_00655	COG0531	amino acid
HUW46_00657	COG3321	synthase
HUW46_00657	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00657	COG0604	alcohol dehydrogenase
HUW46_00659	COG0577	efflux transmembrane transporter activity
HUW46_00659	COG1136	(ABC) transporter
HUW46_00664	COG2356	endonuclease I
HUW46_00675	COG4106	trans-aconitate 2-methyltransferase activity
HUW46_00678	COG1595	DNA-templated transcription, initiation
HUW46_00689	COG2197	response regulator
HUW46_00690	COG4585	Histidine kinase
HUW46_00692	COG1131	(ABC) transporter
HUW46_00693	COG0423	glycine-tRNA ligase activity
HUW46_00701	COG0701	Predicted permease
HUW46_00703	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUW46_00704	COG1381	Involved in DNA repair and RecF pathway recombination
HUW46_00706	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUW46_00709	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW46_00711	COG0537	adenosine 5'-monophosphoramidase activity
HUW46_00713	COG0484	heat shock protein binding
HUW46_00714	COG1420	regulation of RNA biosynthetic process
HUW46_00719	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW46_00722	COG1953	Uracil, thiamine, allantoin
HUW46_00724	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW46_00730	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_00732	COG3386	PFAM SMP-30 Gluconolaconase
HUW46_00736	COG0577	efflux transmembrane transporter activity
HUW46_00737	COG1136	(ABC) transporter
HUW46_00737	COG0577	efflux transmembrane transporter activity
HUW46_00752	COG2732	(Barnase) inhibitor
HUW46_00755	COG0604	alcohol dehydrogenase
HUW46_00757	COG0531	amino acid
HUW46_00758	COG2070	2-Nitropropane dioxygenase
HUW46_00760	COG0481	GTPase activity
HUW46_00762	COG1522	sequence-specific DNA binding
HUW46_00773	COG0268	Binds directly to 16S ribosomal RNA
HUW46_00775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUW46_00778	COG0667	Aldo Keto reductase
HUW46_00779	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_00780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_00781	COG1555	photosystem II stabilization
HUW46_00781	COG1596	polysaccharide export
HUW46_00782	COG1307	EDD domain protein, DegV family
HUW46_00784	COG0406	alpha-ribazole phosphatase activity
HUW46_00785	COG0799	negative regulation of ribosome biogenesis
HUW46_00786	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUW46_00789	COG0477	Major facilitator Superfamily
HUW46_00793	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUW46_00794	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUW46_00795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUW46_00796	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUW46_00797	COG1530	ribonuclease E activity
HUW46_00797	COG1530	ribonuclease E activity
HUW46_00802	COG1131	(ABC) transporter
HUW46_00803	COG2186	Transcriptional regulator
HUW46_00805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW46_00806	COG0105	UTP biosynthetic process
HUW46_00809	COG0285	dihydrofolate synthase activity
HUW46_00810	COG2755	lipolytic protein G-D-S-L family
HUW46_00812	COG2267	carboxylic ester hydrolase activity
HUW46_00813	COG0583	DNA-binding transcription factor activity
HUW46_00814	COG0525	valine-tRNA ligase activity
HUW46_00816	COG0477	Major facilitator Superfamily
HUW46_00818	COG0596	Alpha beta hydrolase
HUW46_00823	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUW46_00831	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW46_00832	COG0740	serine-type endopeptidase activity
HUW46_00833	COG0740	serine-type endopeptidase activity
HUW46_00834	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUW46_00835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW46_00838	COG2205	protein histidine kinase activity
HUW46_00839	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUW46_00842	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW46_00843	COG1490	D-aminoacyl-tRNA deacylase activity
HUW46_00845	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUW46_00845	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUW46_00848	COG4941	Belongs to the sigma-70 factor family
HUW46_00857	COG2188	Transcriptional regulator
HUW46_00863	COG1960	acyl-CoA dehydrogenase activity
HUW46_00864	COG1960	acyl-CoA dehydrogenase activity
HUW46_00867	COG0657	acetylesterase activity
HUW46_00869	COG3903	Transcriptional regulator
HUW46_00869	COG3629	intracellular signal transduction
HUW46_00870	COG1960	acyl-CoA dehydrogenase activity
HUW46_00871	COG1309	transcriptional regulator
HUW46_00875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_00877	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_00879	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW46_00879	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW46_00879	COG1703	isobutyryl-CoA mutase activity
HUW46_00886	COG2018	Roadblock/LC7 domain
HUW46_00889	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW46_00891	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HUW46_00893	COG1309	transcriptional regulator
HUW46_00900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_00901	COG1960	acyl-CoA dehydrogenase activity
HUW46_00903	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_00904	COG1672	PFAM Archaeal ATPase
HUW46_00904	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW46_00910	COG1946	Acyl-CoA thioesterase
HUW46_00915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUW46_00917	COG0204	Acyl-transferase
HUW46_00920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUW46_00922	COG1940	carbohydrate kinase activity
HUW46_00924	COG0003	Pfam Anion-transporting ATPase
HUW46_00932	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUW46_00937	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW46_00938	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW46_00940	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_00944	COG1960	acyl-CoA dehydrogenase activity
HUW46_00945	COG1960	acyl-CoA dehydrogenase activity
HUW46_00946	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_00948	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW46_00953	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW46_00957	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUW46_00960	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUW46_00964	COG4585	Histidine kinase
HUW46_00965	COG2197	response regulator
HUW46_00971	COG2321	neutral zinc metallopeptidase
HUW46_00972	COG1505	serine-type exopeptidase activity
HUW46_00975	COG1595	DNA-templated transcription, initiation
HUW46_00976	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HUW46_00977	COG3795	YCII-related domain
HUW46_00978	COG4941	Belongs to the sigma-70 factor family
HUW46_00982	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW46_00983	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUW46_00985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW46_00987	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUW46_00988	COG2188	Transcriptional regulator
HUW46_00992	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUW46_00994	COG1196	nuclear chromosome segregation
HUW46_00996	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW46_00999	COG0640	Transcriptional regulator
HUW46_01001	COG2358	TRAP transporter, solute receptor (TAXI family
HUW46_01003	COG2205	protein histidine kinase activity
HUW46_01004	COG0745	RESPONSE REGULATOR receiver
HUW46_01005	COG1126	abc transporter atp-binding protein
HUW46_01007	COG0765	amino acid transport
HUW46_01008	COG0765	amino acid transport
HUW46_01011	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW46_01012	COG1309	transcriptional regulator
HUW46_01019	COG0789	Transcriptional regulator
HUW46_01021	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HUW46_01022	COG3842	ATPase activity
HUW46_01024	COG1175	transmembrane transport
HUW46_01027	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW46_01028	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUW46_01032	COG1053	succinate dehydrogenase
HUW46_01036	COG0800	Aldolase
HUW46_01037	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW46_01038	COG2137	regulation of response to DNA damage stimulus
HUW46_01039	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUW46_01042	COG0443	Heat shock 70 kDa protein
HUW46_01043	COG1201	RNA secondary structure unwinding
HUW46_01044	COG0242	peptide deformylase activity
HUW46_01045	COG1959	2 iron, 2 sulfur cluster binding
HUW46_01058	COG0142	geranyltranstransferase activity
HUW46_01068	COG2072	flavoprotein involved in K transport
HUW46_01071	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW46_01074	COG1309	transcriptional regulator
HUW46_01083	COG0488	(ABC) transporter
HUW46_01091	COG0302	gtp cyclohydrolase
HUW46_01092	COG2357	RelA SpoT domain protein
HUW46_01097	COG0586	Pfam SNARE associated Golgi protein
HUW46_01098	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUW46_01099	COG4585	Histidine kinase
HUW46_01100	COG2197	response regulator
HUW46_01101	COG3467	pyridoxamine 5'-phosphate
HUW46_01106	COG2205	protein histidine kinase activity
HUW46_01107	COG0745	RESPONSE REGULATOR receiver
HUW46_01116	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
HUW46_01117	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_01120	COG2226	methyltransferase
HUW46_01122	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW46_01123	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW46_01124	COG2080	2 iron, 2 sulfur cluster binding
HUW46_01134	COG1228	amidohydrolase
HUW46_01135	COG0439	Biotin carboxylase
HUW46_01137	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_01138	COG2755	lipolytic protein G-D-S-L family
HUW46_01143	COG1846	Transcriptional regulator
HUW46_01148	COG0477	Major facilitator Superfamily
HUW46_01149	COG2186	Transcriptional regulator
HUW46_01150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_01152	COG1846	Transcriptional regulator
HUW46_01156	COG3104	oligopeptide transport
HUW46_01165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW46_01168	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW46_01172	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUW46_01173	COG2186	Transcriptional regulator
HUW46_01184	COG0437	4 iron, 4 sulfur cluster binding
HUW46_01185	COG0243	molybdopterin cofactor binding
HUW46_01185	COG3383	formate dehydrogenase (NAD+) activity
HUW46_01186	COG3383	formate dehydrogenase (NAD+) activity
HUW46_01186	COG0243	molybdopterin cofactor binding
HUW46_01189	COG0709	Synthesizes selenophosphate from selenide and ATP
HUW46_01200	COG1733	regulation of RNA biosynthetic process
HUW46_01202	COG1982	Orn Lys Arg decarboxylase major
HUW46_01203	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_01205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW46_01206	COG4106	trans-aconitate 2-methyltransferase activity
HUW46_01213	COG4585	Histidine kinase
HUW46_01214	COG2197	response regulator
HUW46_01231	COG1222	aaa ATPase
HUW46_01233	COG0823	Involved in the tonB-independent uptake of proteins
HUW46_01236	COG3629	intracellular signal transduction
HUW46_01236	COG3903	Transcriptional regulator
HUW46_01237	COG3629	intracellular signal transduction
HUW46_01237	COG3903	Transcriptional regulator
HUW46_01238	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW46_01238	COG2755	lipolytic protein G-D-S-L family
HUW46_01239	COG1215	transferase activity, transferring glycosyl groups
HUW46_01246	COG1960	acyl-CoA dehydrogenase activity
HUW46_01247	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_01248	COG2030	dehydratase
HUW46_01250	COG0183	Belongs to the thiolase family
HUW46_01256	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW46_01261	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW46_01273	COG1120	ATPase activity
HUW46_01274	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_01276	COG4106	trans-aconitate 2-methyltransferase activity
HUW46_01277	COG1132	(ABC) transporter
HUW46_01278	COG1132	(ABC) transporter
HUW46_01279	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW46_01280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW46_01281	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW46_01282	COG0019	diaminopimelate decarboxylase activity
HUW46_01284	COG2226	methyltransferase
HUW46_01285	COG0640	Transcriptional regulator
HUW46_01289	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_01292	COG0477	Major facilitator Superfamily
HUW46_01295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW46_01309	COG0583	DNA-binding transcription factor activity
HUW46_01313	COG2205	protein histidine kinase activity
HUW46_01326	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW46_01331	COG0298	carbon dioxide binding
HUW46_01333	COG0309	Hydrogenase expression formation protein (HypE)
HUW46_01336	COG0531	amino acid
HUW46_01337	COG2235	arginine
HUW46_01338	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW46_01339	COG0549	Belongs to the carbamate kinase family
HUW46_01348	COG3559	Exporter of polyketide antibiotics
HUW46_01349	COG1131	(ABC) transporter
HUW46_01353	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW46_01356	COG0493	'glutamate synthase
HUW46_01357	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUW46_01358	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUW46_01359	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUW46_01360	COG1830	Aldolase
HUW46_01361	COG0469	pyruvate kinase activity
HUW46_01365	COG2920	part of a sulfur-relay system
HUW46_01367	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUW46_01370	COG2172	sigma factor antagonist activity
HUW46_01371	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW46_01372	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW46_01378	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUW46_01381	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUW46_01384	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUW46_01386	COG0517	IMP dehydrogenase activity
HUW46_01386	COG0617	tRNA 3'-terminal CCA addition
HUW46_01386	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW46_01391	COG0517	IMP dehydrogenase activity
HUW46_01391	COG0617	tRNA 3'-terminal CCA addition
HUW46_01391	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW46_01407	COG1271	oxidase subunit
HUW46_01408	COG1294	oxidase, subunit
HUW46_01409	COG4988	ABC transporter
HUW46_01411	COG2326	polyphosphate kinase activity
HUW46_01415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUW46_01417	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW46_01418	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW46_01419	COG0473	3-isopropylmalate dehydrogenase activity
HUW46_01420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW46_01423	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUW46_01424	COG0440	acetolactate synthase activity
HUW46_01427	COG0129	dihydroxy-acid dehydratase activity
HUW46_01430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW46_01434	COG0395	ABC-type sugar transport system, permease component
HUW46_01435	COG1175	transmembrane transport
HUW46_01439	COG0673	inositol 2-dehydrogenase activity
HUW46_01440	COG0531	amino acid
HUW46_01441	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW46_01444	COG2409	Drug exporters of the RND superfamily
HUW46_01445	COG0477	Major facilitator Superfamily
HUW46_01446	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_01449	COG2814	Major facilitator Superfamily
HUW46_01467	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_01468	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW46_01468	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW46_01469	COG2130	NADP-dependent
HUW46_01472	COG1643	Atp-dependent helicase
HUW46_01485	COG1120	ATPase activity
HUW46_01486	COG4122	O-methyltransferase activity
HUW46_01488	COG1960	acyl-CoA dehydrogenase activity
HUW46_01490	COG3958	Transketolase
HUW46_01491	COG3959	Transketolase, thiamine diphosphate binding domain
HUW46_01494	COG2814	Major facilitator Superfamily
HUW46_01495	COG4336	lyase activity
HUW46_01496	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUW46_01497	COG1984	allophanate hydrolase subunit 2
HUW46_01501	COG0251	oxidation-reduction process
HUW46_01503	COG1309	transcriptional regulator
HUW46_01504	COG2409	Drug exporters of the RND superfamily
HUW46_01507	COG0131	Imidazoleglycerol-phosphate dehydratase
HUW46_01509	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUW46_01522	COG1674	ftsk spoiiie
HUW46_01531	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW46_01531	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW46_01534	COG1404	Belongs to the peptidase S8 family
HUW46_01535	COG4585	Histidine kinase
HUW46_01536	COG0157	Belongs to the NadC ModD family
HUW46_01537	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUW46_01538	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUW46_01540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUW46_01543	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUW46_01544	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUW46_01545	COG0659	secondary active sulfate transmembrane transporter activity
HUW46_01546	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUW46_01549	COG0438	transferase activity, transferring glycosyl groups
HUW46_01553	COG1876	peptidase activity
HUW46_01555	COG1136	(ABC) transporter
HUW46_01560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUW46_01562	COG2010	Cytochrome c
HUW46_01563	COG1845	cytochrome c oxidase, subunit III
HUW46_01566	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW46_01568	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUW46_01570	COG2409	Drug exporters of the RND superfamily
HUW46_01573	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW46_01577	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW46_01577	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUW46_01579	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW46_01583	COG4221	oxidoreductase activity
HUW46_01585	COG1309	transcriptional regulator
HUW46_01586	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW46_01592	COG2186	Transcriptional regulator
HUW46_01593	COG1760	l-serine dehydratase
HUW46_01594	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUW46_01595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW46_01596	COG0509	glycine decarboxylation via glycine cleavage system
HUW46_01597	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUW46_01598	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW46_01598	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW46_01601	COG1404	Belongs to the peptidase S8 family
HUW46_01604	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUW46_01608	COG0673	inositol 2-dehydrogenase activity
HUW46_01609	COG1609	Transcriptional regulator
HUW46_01614	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW46_01616	COG3718	enzyme involved in inositol metabolism
HUW46_01617	COG3962	Belongs to the TPP enzyme family
HUW46_01641	COG0746	molybdenum cofactor guanylyltransferase activity
HUW46_01642	COG1414	Transcriptional regulator
HUW46_01645	COG3485	protocatechuate 3,4-dioxygenase
HUW46_01646	COG3485	protocatechuate 3,4-dioxygenase
HUW46_01647	COG0183	Belongs to the thiolase family
HUW46_01648	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUW46_01649	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUW46_01662	COG2186	Transcriptional regulator
HUW46_01663	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW46_01664	COG1129	ABC transporter
HUW46_01666	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_01667	COG4948	Mandelate Racemase Muconate Lactonizing
HUW46_01675	COG1802	Transcriptional regulator
HUW46_01682	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUW46_01690	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_01691	COG1024	Enoyl-CoA hydratase
HUW46_01693	COG1960	acyl-CoA dehydrogenase activity
HUW46_01695	COG0477	Major facilitator Superfamily
HUW46_01700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUW46_01701	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUW46_01701	COG0235	Class ii aldolase
HUW46_01703	COG0028	Belongs to the TPP enzyme family
HUW46_01707	COG2130	NADP-dependent
HUW46_01710	COG0277	FAD linked oxidase domain protein
HUW46_01710	COG0247	lactate metabolic process
HUW46_01714	COG1739	Uncharacterized protein family UPF0029
HUW46_01715	COG0069	glutamate synthase activity
HUW46_01715	COG0070	glutamate synthase
HUW46_01715	COG0067	glutamate synthase
HUW46_01720	COG1349	DNA-binding transcription factor activity
HUW46_01722	COG3842	ATPase activity
HUW46_01723	COG0395	ABC-type sugar transport system, permease component
HUW46_01724	COG3833	ABC-type maltose transport systems, permease component
HUW46_01726	COG0673	inositol 2-dehydrogenase activity
HUW46_01727	COG1349	DNA-binding transcription factor activity
HUW46_01729	COG1105	Belongs to the carbohydrate kinase PfkB family
HUW46_01734	COG1492	cobalamin metabolic process
HUW46_01735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUW46_01737	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUW46_01738	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUW46_01741	COG1797	cobyrinic acid a,c-diamide synthase activity
HUW46_01751	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW46_01754	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUW46_01755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUW46_01758	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW46_01759	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW46_01760	COG3396	Phenylacetate-CoA oxygenase
HUW46_01761	COG3460	Phenylacetate-CoA oxygenase
HUW46_01762	COG3396	Phenylacetate-CoA oxygenase
HUW46_01763	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_01763	COG2030	dehydratase
HUW46_01764	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_01765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUW46_01765	COG2050	protein possibly involved in aromatic compounds catabolism
HUW46_01767	COG1309	transcriptional regulator
HUW46_01772	COG2072	flavoprotein involved in K transport
HUW46_01774	COG2183	response to ionizing radiation
HUW46_01777	COG0583	DNA-binding transcription factor activity
HUW46_01787	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUW46_01789	COG3629	intracellular signal transduction
HUW46_01789	COG3903	Transcriptional regulator
HUW46_01794	COG0242	peptide deformylase activity
HUW46_01796	COG1620	l-lactate permease
HUW46_01797	COG1414	Transcriptional regulator
HUW46_01799	COG0300	oxidoreductase activity
HUW46_01800	COG0667	Aldo Keto reductase
HUW46_01810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW46_01812	COG0596	Alpha beta hydrolase
HUW46_01815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_01818	COG1940	carbohydrate kinase activity
HUW46_01828	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW46_01832	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUW46_01836	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW46_01837	COG0187	DNA topoisomerase II activity
HUW46_01840	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW46_01844	COG3795	YCII-related domain
HUW46_01851	COG2223	nitrite transmembrane transporter activity
HUW46_01852	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_01856	COG0488	(ABC) transporter
HUW46_01859	COG3795	YCII-related domain
HUW46_01860	COG4941	Belongs to the sigma-70 factor family
HUW46_01861	COG1309	transcriptional regulator
HUW46_01862	COG2268	Band 7 protein
HUW46_01864	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUW46_01867	COG3706	GGDEF domain
HUW46_01871	COG0583	DNA-binding transcription factor activity
HUW46_01873	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUW46_01883	COG0596	Alpha beta hydrolase
HUW46_01885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUW46_01886	COG2079	MmgE PrpD family protein
HUW46_01889	COG1960	acyl-CoA dehydrogenase activity
HUW46_01890	COG1024	Enoyl-CoA hydratase
HUW46_01893	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_01894	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW46_01895	COG0477	Major facilitator Superfamily
HUW46_01900	COG1486	melibiose metabolic process
HUW46_01903	COG0596	Alpha beta hydrolase
HUW46_01911	COG2197	response regulator
HUW46_01916	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW46_01919	COG1418	mRNA catabolic process
HUW46_01923	COG2814	Major facilitator Superfamily
HUW46_01926	COG2197	response regulator
HUW46_01934	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW46_01936	COG4585	Histidine kinase
HUW46_01937	COG2197	response regulator
HUW46_01940	COG0604	alcohol dehydrogenase
HUW46_01940	COG3321	synthase
HUW46_01947	COG3321	synthase
HUW46_01947	COG0604	alcohol dehydrogenase
HUW46_01947	COG3321	synthase
HUW46_01947	COG0604	alcohol dehydrogenase
HUW46_01949	COG0604	alcohol dehydrogenase
HUW46_01949	COG3321	synthase
HUW46_01954	COG1819	glycosyl
HUW46_01955	COG1132	(ABC) transporter
HUW46_01956	COG1309	transcriptional regulator
HUW46_01959	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_01961	COG4585	Histidine kinase
HUW46_01963	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUW46_01965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HUW46_01968	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW46_01969	COG0433	COG0433 Predicted ATPase
HUW46_01970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUW46_01972	COG1376	ErfK ybiS ycfS ynhG family protein
HUW46_01974	COG2318	DinB family
HUW46_01979	COG1846	Transcriptional regulator
HUW46_01980	COG0726	polysaccharide deacetylase
HUW46_01981	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUW46_01982	COG1309	transcriptional regulator
HUW46_01984	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_01986	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW46_01988	COG4585	Histidine kinase
HUW46_01989	COG2197	response regulator
HUW46_01997	COG0765	amino acid transport
HUW46_01998	COG0765	amino acid transport
HUW46_02001	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_02005	COG1309	transcriptional regulator
HUW46_02006	COG0778	Nitroreductase
HUW46_02009	COG0583	DNA-binding transcription factor activity
HUW46_02016	COG2207	Transcriptional regulator
HUW46_02035	COG3012	SEC-C Motif Domain Protein
HUW46_02039	COG0642	Histidine kinase
HUW46_02041	COG0765	amino acid transport
HUW46_02042	COG0477	Major facilitator Superfamily
HUW46_02043	COG0477	Major facilitator Superfamily
HUW46_02044	COG0477	Major facilitator Superfamily
HUW46_02045	COG1733	regulation of RNA biosynthetic process
HUW46_02049	COG2084	Dehydrogenase
HUW46_02051	COG0154	amidase activity
HUW46_02052	COG0596	Alpha beta hydrolase
HUW46_02055	COG2226	methyltransferase
HUW46_02075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW46_02112	COG4626	Terminase
HUW46_02112	COG1802	Transcriptional regulator
HUW46_02114	COG0302	gtp cyclohydrolase
HUW46_02115	COG0602	queuosine metabolic process
HUW46_02116	COG0720	synthase
HUW46_02162	COG1136	(ABC) transporter
HUW46_02163	COG2197	response regulator
HUW46_02164	COG4585	Histidine kinase
HUW46_02168	COG3903	Transcriptional regulator
HUW46_02168	COG3629	intracellular signal transduction
HUW46_02169	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_02170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW46_02173	COG1233	COG1233 Phytoene dehydrogenase and related
HUW46_02186	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_02187	COG2116	formate transmembrane transporter activity
HUW46_02190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW46_02192	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_02197	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW46_02198	COG1605	Chorismate mutase
HUW46_02199	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW46_02199	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW46_02201	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUW46_02203	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUW46_02205	COG0702	epimerase
HUW46_02207	COG2197	response regulator
HUW46_02208	COG4585	Histidine kinase
HUW46_02211	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW46_02219	COG3383	formate dehydrogenase (NAD+) activity
HUW46_02221	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW46_02222	COG3938	Belongs to the proline racemase family
HUW46_02224	COG0531	amino acid
HUW46_02227	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_02228	COG1120	ATPase activity
HUW46_02234	COG0745	RESPONSE REGULATOR receiver
HUW46_02235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_02238	COG2197	response regulator
HUW46_02239	COG4585	Histidine kinase
HUW46_02242	COG1136	(ABC) transporter
HUW46_02243	COG1234	tRNA 3'-trailer cleavage
HUW46_02255	COG0300	oxidoreductase activity
HUW46_02264	COG2372	response to copper ion
HUW46_02264	COG1276	copper resistance
HUW46_02266	COG0640	Transcriptional regulator
HUW46_02278	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUW46_02287	COG0243	molybdopterin cofactor binding
HUW46_02288	COG1280	lysine exporter protein (LysE YggA)
HUW46_02289	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUW46_02291	COG1846	Transcriptional regulator
HUW46_02293	COG2072	flavoprotein involved in K transport
HUW46_02294	COG0477	Major facilitator Superfamily
HUW46_02303	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUW46_02306	COG2267	carboxylic ester hydrolase activity
HUW46_02313	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUW46_02314	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW46_02315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW46_02316	COG0531	amino acid
HUW46_02324	COG1131	(ABC) transporter
HUW46_02327	COG2197	response regulator
HUW46_02335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW46_02341	COG0583	DNA-binding transcription factor activity
HUW46_02342	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW46_02342	COG1902	pentaerythritol trinitrate reductase activity
HUW46_02358	COG0745	RESPONSE REGULATOR receiver
HUW46_02359	COG2205	protein histidine kinase activity
HUW46_02361	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUW46_02362	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW46_02364	COG1063	alcohol dehydrogenase
HUW46_02366	COG0640	Transcriptional regulator
HUW46_02373	COG3903	Transcriptional regulator
HUW46_02373	COG3629	intracellular signal transduction
HUW46_02375	COG3629	intracellular signal transduction
HUW46_02375	COG3903	Transcriptional regulator
HUW46_02389	COG3883	PFAM NLP P60 protein
HUW46_02389	COG0791	NLP P60 protein
HUW46_02393	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW46_02394	COG1643	Atp-dependent helicase
HUW46_02398	COG2197	response regulator
HUW46_02405	COG1228	amidohydrolase
HUW46_02408	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUW46_02409	COG2986	histidine ammonia-lyase
HUW46_02412	COG1278	Cold shock
HUW46_02420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUW46_02424	COG4585	Histidine kinase
HUW46_02425	COG2197	response regulator
HUW46_02429	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUW46_02430	COG2177	Part of the ABC transporter FtsEX involved in
HUW46_02431	COG2884	Cell division ATP-binding protein ftsE
HUW46_02432	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUW46_02436	COG1615	UPF0182 protein
HUW46_02438	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUW46_02442	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUW46_02446	COG1802	Transcriptional regulator
HUW46_02447	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW46_02448	COG2271	Major facilitator Superfamily
HUW46_02449	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUW46_02456	COG0174	glutamine synthetase
HUW46_02459	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUW46_02463	COG1522	sequence-specific DNA binding
HUW46_02467	COG0174	glutamine synthetase
HUW46_02472	COG0653	protein targeting
HUW46_02473	COG2161	toxin-antitoxin pair type II binding
HUW46_02474	COG4115	mRNA cleavage
HUW46_02477	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW46_02477	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUW46_02479	COG1846	Transcriptional regulator
HUW46_02481	COG1063	alcohol dehydrogenase
HUW46_02482	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW46_02483	COG1309	transcriptional regulator
HUW46_02484	COG2318	DinB family
HUW46_02486	COG1846	Transcriptional regulator
HUW46_02488	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW46_02488	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUW46_02489	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUW46_02494	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_02508	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUW46_02512	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUW46_02514	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUW46_02517	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUW46_02518	COG2186	Transcriptional regulator
HUW46_02519	COG3265	gluconokinase activity
HUW46_02521	COG0640	Transcriptional regulator
HUW46_02524	COG1486	melibiose metabolic process
HUW46_02525	COG0395	ABC-type sugar transport system, permease component
HUW46_02526	COG1175	transmembrane transport
HUW46_02529	COG0277	FAD linked oxidase domain protein
HUW46_02532	COG0612	Peptidase, M16
HUW46_02536	COG2321	neutral zinc metallopeptidase
HUW46_02540	COG3328	transposase activity
HUW46_02544	COG0714	Associated with various cellular activities
HUW46_02554	COG0210	DNA helicase
HUW46_02558	COG2378	regulation of single-species biofilm formation
HUW46_02566	COG3328	transposase activity
HUW46_02575	COG0513	Belongs to the DEAD box helicase family
HUW46_02580	COG2095	MarC family integral membrane protein
HUW46_02581	COG0613	PHP domain protein
HUW46_02585	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_02589	COG0598	Magnesium transport protein CorA
HUW46_02593	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUW46_02612	COG0330	HflC and HflK could
HUW46_02617	COG2239	Acts as a magnesium transporter
HUW46_02620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW46_02621	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW46_02625	COG2814	Major facilitator Superfamily
HUW46_02626	COG0583	DNA-binding transcription factor activity
HUW46_02627	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUW46_02629	COG1024	Enoyl-CoA hydratase
HUW46_02630	COG2818	Glycosylase
HUW46_02635	COG1271	oxidase subunit
HUW46_02636	COG1294	oxidase, subunit
HUW46_02637	COG1132	(ABC) transporter
HUW46_02638	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUW46_02640	COG0477	Major facilitator Superfamily
HUW46_02641	COG0463	Glycosyl transferase, family 2
HUW46_02644	COG1611	Belongs to the LOG family
HUW46_02645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW46_02650	COG1309	transcriptional regulator
HUW46_02655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUW46_02656	COG0778	Nitroreductase
HUW46_02656	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUW46_02658	COG1725	Transcriptional regulator
HUW46_02663	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUW46_02669	COG0438	transferase activity, transferring glycosyl groups
HUW46_02675	COG1316	TRANSCRIPTIONal
HUW46_02676	COG1316	TRANSCRIPTIONal
HUW46_02678	COG2259	Doxx family
HUW46_02682	COG4106	trans-aconitate 2-methyltransferase activity
HUW46_02687	COG0477	Major facilitator Superfamily
HUW46_02689	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HUW46_02694	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_02703	COG0477	Major facilitator Superfamily
HUW46_02705	COG4585	Histidine kinase
HUW46_02706	COG2197	response regulator
HUW46_02707	COG2197	response regulator
HUW46_02711	COG2205	protein histidine kinase activity
HUW46_02712	COG0745	RESPONSE REGULATOR receiver
HUW46_02713	COG0483	inositol monophosphate 1-phosphatase activity
HUW46_02715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_02720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW46_02723	COG3103	Sh3 type 3 domain protein
HUW46_02723	COG0791	NLP P60 protein
HUW46_02723	COG1388	LysM domain
HUW46_02729	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW46_02730	COG0402	S-adenosylhomocysteine deaminase activity
HUW46_02731	COG2186	Transcriptional regulator
HUW46_02735	COG0583	DNA-binding transcription factor activity
HUW46_02738	COG1309	transcriptional regulator
HUW46_02740	COG1595	DNA-templated transcription, initiation
HUW46_02741	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW46_02742	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW46_02743	COG1396	sequence-specific DNA binding
HUW46_02750	COG0640	Transcriptional regulator
HUW46_02753	COG4585	Histidine kinase
HUW46_02754	COG2197	response regulator
HUW46_02755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW46_02757	COG2318	DinB family
HUW46_02759	COG2936	dipeptidyl-peptidase activity
HUW46_02767	COG0424	maF-like protein
HUW46_02768	COG1301	dicarboxylic acid transport
HUW46_02771	COG4770	biotin carboxylase activity
HUW46_02774	COG4585	Histidine kinase
HUW46_02775	COG2197	response regulator
HUW46_02777	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_02779	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUW46_02780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW46_02781	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUW46_02782	COG2367	Beta-lactamase
HUW46_02790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUW46_02790	COG1473	amidohydrolase
HUW46_02795	COG0515	serine threonine protein kinase
HUW46_02798	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW46_02803	COG1228	amidohydrolase
HUW46_02805	COG0124	histidyl-tRNA synthetase
HUW46_02806	COG0667	Aldo Keto reductase
HUW46_02807	COG0667	Aldo Keto reductase
HUW46_02819	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUW46_02820	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_02821	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_02823	COG2124	cytochrome p450
HUW46_02826	COG3842	ATPase activity
HUW46_02827	COG0395	ABC-type sugar transport system, permease component
HUW46_02832	COG2124	cytochrome p450
HUW46_02837	COG2271	Major facilitator Superfamily
HUW46_02838	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUW46_02841	COG0583	DNA-binding transcription factor activity
HUW46_02846	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUW46_02848	COG3845	ABC transporter
HUW46_02849	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW46_02850	COG1082	Xylose isomerase domain protein TIM barrel
HUW46_02851	COG3345	alpha-galactosidase
HUW46_02852	COG2009	succinate dehydrogenase
HUW46_02855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUW46_02862	COG1686	Belongs to the peptidase S11 family
HUW46_02866	COG1295	ribonuclease BN
HUW46_02867	COG0180	Tryptophanyl-tRNA synthetase
HUW46_02868	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUW46_02872	COG2267	carboxylic ester hydrolase activity
HUW46_02875	COG0708	Exodeoxyribonuclease III
HUW46_02877	COG1234	tRNA 3'-trailer cleavage
HUW46_02889	COG2197	response regulator
HUW46_02900	COG2814	Major facilitator Superfamily
HUW46_02903	COG0367	asparagine synthase
HUW46_02904	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUW46_02905	COG2814	Major facilitator Superfamily
HUW46_02907	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW46_02914	COG0667	Aldo Keto reductase
HUW46_02915	COG0587	DNA-directed DNA polymerase activity
HUW46_02927	COG0640	Transcriptional regulator
HUW46_02932	COG1177	transmembrane transport
HUW46_02933	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUW46_02934	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUW46_02935	COG3842	ATPase activity
HUW46_02936	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_02939	COG1131	(ABC) transporter
HUW46_02942	COG2267	carboxylic ester hydrolase activity
HUW46_02944	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUW46_02950	COG0596	Alpha beta hydrolase
HUW46_02952	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_02953	COG0138	bifunctional purine biosynthesis protein purh
HUW46_02958	COG0045	succinate-CoA ligase (ADP-forming) activity
HUW46_02971	COG0515	serine threonine protein kinase
HUW46_02973	COG0583	DNA-binding transcription factor activity
HUW46_02980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUW46_02980	COG0519	Catalyzes the synthesis of GMP from XMP
HUW46_02981	COG1063	alcohol dehydrogenase
HUW46_02982	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_02986	COG0516	GMP reductase activity
HUW46_02995	COG1309	transcriptional regulator
HUW46_02996	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_02997	COG0459	protein refolding
HUW46_02998	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW46_03001	COG3540	Alkaline phosphatase
HUW46_03003	COG1215	transferase activity, transferring glycosyl groups
HUW46_03007	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW46_03008	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW46_03009	COG0456	acetyltransferase
HUW46_03010	COG1214	PFAM Peptidase M22, glycoprotease
HUW46_03010	COG0456	acetyltransferase
HUW46_03012	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_03013	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUW46_03013	COG0825	malonyl-CoA metabolic process
HUW46_03015	COG2267	carboxylic ester hydrolase activity
HUW46_03016	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUW46_03017	COG3842	ATPase activity
HUW46_03018	COG1070	Carbohydrate kinase
HUW46_03019	COG1349	DNA-binding transcription factor activity
HUW46_03020	COG1063	alcohol dehydrogenase
HUW46_03022	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW46_03027	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW46_03029	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUW46_03035	COG0443	Heat shock 70 kDa protein
HUW46_03036	COG1674	ftsk spoiiie
HUW46_03038	COG1404	Belongs to the peptidase S8 family
HUW46_03045	COG0101	tRNA pseudouridine synthase activity
HUW46_03046	COG0203	ribosomal protein L17
HUW46_03047	COG0202	RNA polymerase activity
HUW46_03048	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUW46_03049	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUW46_03051	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW46_03052	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUW46_03053	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW46_03055	COG0563	adenylate kinase activity
HUW46_03059	COG0200	Binds to the 23S rRNA
HUW46_03060	COG1841	ribosomal large subunit assembly
HUW46_03061	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUW46_03062	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUW46_03064	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUW46_03066	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUW46_03067	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUW46_03068	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUW46_03069	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUW46_03070	COG0255	Belongs to the universal ribosomal protein uL29 family
HUW46_03072	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW46_03073	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUW46_03074	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUW46_03075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW46_03076	COG0089	rRNA binding
HUW46_03077	COG0088	Forms part of the polypeptide exit tunnel
HUW46_03078	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUW46_03079	COG0051	transcription antitermination factor activity, RNA binding
HUW46_03081	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW46_03082	COG0049	tRNA binding
HUW46_03083	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUW46_03090	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUW46_03095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUW46_03102	COG2936	dipeptidyl-peptidase activity
HUW46_03106	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUW46_03111	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW46_03114	COG0222	ribosome binding
HUW46_03115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUW46_03117	COG1414	Transcriptional regulator
HUW46_03119	COG1960	acyl-CoA dehydrogenase activity
HUW46_03121	COG0081	regulation of translation
HUW46_03122	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUW46_03124	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUW46_03126	COG0436	Aminotransferase
HUW46_03130	COG2755	lipolytic protein G-D-S-L family
HUW46_03132	COG2030	dehydratase
HUW46_03134	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUW46_03140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUW46_03141	COG0586	Pfam SNARE associated Golgi protein
HUW46_03145	COG1819	glycosyl
HUW46_03152	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW46_03153	COG1129	ABC transporter
HUW46_03154	COG1879	ABC-type sugar transport system periplasmic component
HUW46_03155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_03156	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_03157	COG1132	(ABC) transporter
HUW46_03158	COG1132	(ABC) transporter
HUW46_03164	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUW46_03165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUW46_03166	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUW46_03170	COG0596	Alpha beta hydrolase
HUW46_03172	COG2378	regulation of single-species biofilm formation
HUW46_03184	COG1666	GTP binding
HUW46_03199	COG0673	inositol 2-dehydrogenase activity
HUW46_03200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW46_03216	COG2244	polysaccharide biosynthetic process
HUW46_03223	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUW46_03226	COG2304	oxidoreductase activity
HUW46_03227	COG1834	amidinotransferase
HUW46_03228	COG1522	sequence-specific DNA binding
HUW46_03230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUW46_03230	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUW46_03231	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUW46_03239	COG0142	geranyltranstransferase activity
HUW46_03241	COG2318	DinB family
HUW46_03245	COG1007	ATP synthesis coupled electron transport
HUW46_03247	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW46_03248	COG0713	ATP synthesis coupled electron transport
HUW46_03250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW46_03251	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW46_03252	COG1034	ATP synthesis coupled electron transport
HUW46_03255	COG0649	NAD binding
HUW46_03256	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW46_03257	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW46_03260	COG2226	methyltransferase
HUW46_03262	COG0702	epimerase
HUW46_03265	COG0438	transferase activity, transferring glycosyl groups
HUW46_03273	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUW46_03275	COG0596	Alpha beta hydrolase
HUW46_03278	COG1309	transcriptional regulator
HUW46_03289	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUW46_03291	COG0785	Cytochrome C biogenesis protein
HUW46_03295	COG0406	alpha-ribazole phosphatase activity
HUW46_03296	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUW46_03298	COG0577	efflux transmembrane transporter activity
HUW46_03298	COG1136	(ABC) transporter
HUW46_03299	COG1136	(ABC) transporter
HUW46_03305	COG1587	Uroporphyrinogen-III synthase
HUW46_03305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUW46_03306	COG0181	hydroxymethylbilane synthase activity
HUW46_03307	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW46_03308	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUW46_03312	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_03313	COG1595	DNA-templated transcription, initiation
HUW46_03320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUW46_03322	COG0506	proline dehydrogenase activity
HUW46_03327	COG5002	protein histidine kinase activity
HUW46_03328	COG0667	Aldo Keto reductase
HUW46_03330	COG0588	phosphoglycerate mutase activity
HUW46_03333	COG0438	transferase activity, transferring glycosyl groups
HUW46_03336	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUW46_03341	COG0788	formyltetrahydrofolate deformylase activity
HUW46_03342	COG2130	NADP-dependent
HUW46_03345	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUW46_03347	COG1174	glycine betaine transport
HUW46_03348	COG1174	glycine betaine transport
HUW46_03350	COG2986	histidine ammonia-lyase
HUW46_03351	COG2423	ornithine cyclodeaminase activity
HUW46_03357	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW46_03361	COG3226	Transcriptional regulator
HUW46_03363	COG2733	membrane
HUW46_03367	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_03368	COG2364	Membrane
HUW46_03373	COG3226	Transcriptional regulator
HUW46_03383	COG1309	transcriptional regulator
HUW46_03390	COG1674	ftsk spoiiie
HUW46_03392	COG2814	Major facilitator Superfamily
HUW46_03394	COG0492	ferredoxin-NADP+ reductase activity
HUW46_03394	COG3118	belongs to the thioredoxin family
HUW46_03403	COG2175	clavaminate synthase activity
HUW46_03412	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW46_03417	COG1473	amidohydrolase
HUW46_03420	COG0287	Prephenate dehydrogenase
HUW46_03435	COG1131	(ABC) transporter
HUW46_03436	COG3559	Exporter of polyketide antibiotics
HUW46_03440	COG2197	response regulator
HUW46_03441	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW46_03443	COG3469	chitinase activity
HUW46_03447	COG2197	response regulator
HUW46_03448	COG1280	lysine exporter protein (LysE YggA)
HUW46_03456	COG1309	transcriptional regulator
HUW46_03457	COG1846	Transcriptional regulator
HUW46_03459	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_03460	COG1309	transcriptional regulator
HUW46_03465	COG0671	phosphoesterase, PA-phosphatase related
HUW46_03467	COG0745	RESPONSE REGULATOR receiver
HUW46_03470	COG2226	methyltransferase
HUW46_03482	COG2076	Multidrug Resistance protein
HUW46_03496	COG1396	sequence-specific DNA binding
HUW46_03497	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HUW46_03500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW46_03500	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUW46_03501	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW46_03503	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW46_03512	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUW46_03515	COG3285	dna ligase
HUW46_03515	COG1793	dna ligase
HUW46_03516	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUW46_03520	COG2197	response regulator
HUW46_03522	COG1522	sequence-specific DNA binding
HUW46_03524	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW46_03524	COG1672	PFAM Archaeal ATPase
HUW46_03529	COG3290	protein histidine kinase activity
HUW46_03530	COG4565	transcriptional regulatory protein
HUW46_03581	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUW46_03582	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW46_03589	COG4974	Belongs to the 'phage' integrase family
HUW46_03597	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HUW46_03598	COG1086	Polysaccharide biosynthesis protein
HUW46_03599	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW46_03600	COG2089	acid synthase
HUW46_03606	COG1216	Glycosyl transferase, family 2
HUW46_03612	COG1216	Glycosyl transferase, family 2
HUW46_03614	COG0277	FAD linked oxidase domain protein
HUW46_03615	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_03622	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUW46_03626	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_03627	COG0561	phosphatase activity
HUW46_03635	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_03636	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_03638	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW46_03639	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW46_03642	COG0110	maltose O-acetyltransferase activity
HUW46_03643	COG0438	transferase activity, transferring glycosyl groups
HUW46_03645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW46_03648	COG0477	Major facilitator Superfamily
HUW46_03653	COG3795	YCII-related domain
HUW46_03654	COG4941	Belongs to the sigma-70 factor family
HUW46_03658	COG0579	oxidoreductase
HUW46_03661	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUW46_03662	COG0596	Alpha beta hydrolase
HUW46_03663	COG3766	membrane
HUW46_03664	COG0754	glutathionylspermidine amidase activity
HUW46_03669	COG0406	alpha-ribazole phosphatase activity
HUW46_03671	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HUW46_03676	COG4715	Zinc finger, swim domain protein
HUW46_03682	COG4988	ABC transporter
HUW46_03683	COG1294	oxidase, subunit
HUW46_03684	COG1271	oxidase subunit
HUW46_03685	COG0702	epimerase
HUW46_03700	COG1595	DNA-templated transcription, initiation
HUW46_03708	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW46_03710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW46_03714	COG3275	phosphorelay sensor kinase activity
HUW46_03715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW46_03724	COG2814	Major facilitator Superfamily
HUW46_03727	COG1396	sequence-specific DNA binding
HUW46_03735	COG2197	response regulator
HUW46_03736	COG0584	glycerophosphoryl diester phosphodiesterase
HUW46_03738	COG4585	Histidine kinase
HUW46_03741	COG0477	Major facilitator Superfamily
HUW46_03756	COG1174	glycine betaine transport
HUW46_03758	COG1174	glycine betaine transport
HUW46_03761	COG2372	response to copper ion
HUW46_03768	COG2814	Major facilitator Superfamily
HUW46_03773	COG0702	epimerase
HUW46_03775	COG2301	Belongs to the HpcH HpaI aldolase family
HUW46_03784	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_03785	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_03787	COG0444	Belongs to the ABC transporter superfamily
HUW46_03788	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_03790	COG0747	negative chemotaxis
HUW46_03791	COG2186	Transcriptional regulator
HUW46_03806	COG1716	ATPase activity
HUW46_03807	COG1716	ATPase activity
HUW46_03810	COG0768	penicillin binding
HUW46_03811	COG0515	serine threonine protein kinase
HUW46_03823	COG2197	response regulator
HUW46_03829	COG3764	Sortase (surface protein transpeptidase)
HUW46_03833	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW46_03841	COG4585	Histidine kinase
HUW46_03842	COG2197	response regulator
HUW46_03844	COG3795	YCII-related domain
HUW46_03845	COG4941	Belongs to the sigma-70 factor family
HUW46_03853	COG1396	sequence-specific DNA binding
HUW46_03854	COG0596	Alpha beta hydrolase
HUW46_03863	COG5592	hemerythrin HHE cation binding domain
HUW46_03865	COG1051	belongs to the nudix hydrolase family
HUW46_03868	COG2188	Transcriptional regulator
HUW46_03870	COG1660	Displays ATPase and GTPase activities
HUW46_03890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW46_03891	COG0187	DNA topoisomerase II activity
HUW46_03892	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUW46_03893	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW46_03894	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUW46_03895	COG0592	DNA-directed DNA polymerase activity
HUW46_03899	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUW46_03902	COG0357	Ribosomal RNA small subunit methyltransferase G
HUW46_03903	COG1192	Involved in chromosome partitioning
HUW46_03905	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW46_03909	COG3409	Peptidoglycan-binding domain 1 protein
HUW46_03909	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW46_03910	COG0492	ferredoxin-NADP+ reductase activity
HUW46_03910	COG3118	belongs to the thioredoxin family
HUW46_03918	COG0617	tRNA 3'-terminal CCA addition
HUW46_03926	COG1678	Uncharacterized ACR, COG1678
HUW46_03929	COG0495	leucyl-tRNA aminoacylation
HUW46_03933	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW46_03934	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUW46_03938	COG2197	response regulator
HUW46_03943	COG3384	dioxygenase
HUW46_03953	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW46_03956	COG0305	Participates in initiation and elongation during chromosome replication
HUW46_03961	COG0359	binds to the 23S rRNA
HUW46_03962	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW46_03964	COG0360	Binds together with S18 to 16S ribosomal RNA
HUW46_03969	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUW46_03973	COG0673	inositol 2-dehydrogenase activity
HUW46_03974	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW46_03976	COG1695	Transcriptional regulator
HUW46_03978	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW46_03981	COG2814	Major facilitator Superfamily
HUW46_03982	COG0596	Alpha beta hydrolase
HUW46_03985	COG4221	oxidoreductase activity
HUW46_03987	COG0402	S-adenosylhomocysteine deaminase activity
HUW46_03988	COG2197	response regulator
HUW46_03990	COG1136	(ABC) transporter
HUW46_03997	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_03998	COG2197	response regulator
HUW46_03999	COG4585	Histidine kinase
HUW46_04001	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUW46_04006	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUW46_04008	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUW46_04022	COG0584	glycerophosphoryl diester phosphodiesterase
HUW46_04023	COG1309	transcriptional regulator
HUW46_04024	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04028	COG0183	Belongs to the thiolase family
HUW46_04029	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04030	COG2030	dehydratase
HUW46_04031	COG1309	transcriptional regulator
HUW46_04037	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUW46_04041	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW46_04042	COG0022	dehydrogenase e1 component
HUW46_04045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW46_04047	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_04048	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_04049	COG1309	transcriptional regulator
HUW46_04051	COG1305	Transglutaminase-like
HUW46_04056	COG0765	amino acid transport
HUW46_04057	COG1126	abc transporter atp-binding protein
HUW46_04062	COG0702	epimerase
HUW46_04064	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW46_04070	COG1960	acyl-CoA dehydrogenase activity
HUW46_04071	COG2197	response regulator
HUW46_04072	COG3663	DNA glycosylase
HUW46_04080	COG0737	Belongs to the 5'-nucleotidase family
HUW46_04083	COG0464	growth
HUW46_04091	COG0483	inositol monophosphate 1-phosphatase activity
HUW46_04110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_04113	COG0477	Major facilitator Superfamily
HUW46_04115	COG1024	Enoyl-CoA hydratase
HUW46_04116	COG1960	acyl-CoA dehydrogenase activity
HUW46_04122	COG0247	lactate metabolic process
HUW46_04122	COG2181	nitrate reductase activity
HUW46_04126	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW46_04127	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HUW46_04134	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_04136	COG2226	methyltransferase
HUW46_04143	COG1846	Transcriptional regulator
HUW46_04144	COG1819	glycosyl
HUW46_04149	COG0443	Heat shock 70 kDa protein
HUW46_04150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUW46_04151	COG0484	heat shock protein binding
HUW46_04152	COG0789	Transcriptional regulator
HUW46_04160	COG0542	response to heat
HUW46_04163	COG0300	oxidoreductase activity
HUW46_04166	COG1595	DNA-templated transcription, initiation
HUW46_04176	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW46_04178	COG0243	molybdopterin cofactor binding
HUW46_04182	COG1733	regulation of RNA biosynthetic process
HUW46_04191	COG1072	(Pantothenic acid kinase))
HUW46_04192	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04193	COG0346	lactoylglutathione lyase activity
HUW46_04194	COG0583	DNA-binding transcription factor activity
HUW46_04197	COG2226	methyltransferase
HUW46_04198	COG0586	Pfam SNARE associated Golgi protein
HUW46_04200	COG0477	Major facilitator Superfamily
HUW46_04202	COG3467	pyridoxamine 5'-phosphate
HUW46_04204	COG0477	Major facilitator Superfamily
HUW46_04205	COG0277	FAD linked oxidase domain protein
HUW46_04207	COG0586	Pfam SNARE associated Golgi protein
HUW46_04216	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04217	COG0667	Aldo Keto reductase
HUW46_04218	COG2318	DinB family
HUW46_04228	COG2318	DinB family
HUW46_04231	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUW46_04233	COG0025	NhaP-type Na H and K H
HUW46_04234	COG2814	Major facilitator Superfamily
HUW46_04241	COG0584	glycerophosphoryl diester phosphodiesterase
HUW46_04242	COG2358	TRAP transporter, solute receptor (TAXI family
HUW46_04248	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW46_04248	COG0515	serine threonine protein kinase
HUW46_04249	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW46_04249	COG0515	serine threonine protein kinase
HUW46_04254	COG3953	SLT domain
HUW46_04254	COG5280	Phage tail tape measure protein TP901
HUW46_04256	COG0436	Aminotransferase
HUW46_04264	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUW46_04266	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW46_04267	COG0765	amino acid transport
HUW46_04268	COG1126	abc transporter atp-binding protein
HUW46_04270	COG0730	response to heat
HUW46_04273	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW46_04277	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW46_04278	COG0047	phosphoribosylformylglycinamidine synthase activity
HUW46_04280	COG1132	(ABC) transporter
HUW46_04281	COG1132	(ABC) transporter
HUW46_04282	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW46_04297	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUW46_04298	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUW46_04302	COG4565	transcriptional regulatory protein
HUW46_04303	COG3290	protein histidine kinase activity
HUW46_04315	COG1984	allophanate hydrolase subunit 2
HUW46_04317	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HUW46_04325	COG2897	thiosulfate sulfurtransferase activity
HUW46_04329	COG0745	RESPONSE REGULATOR receiver
HUW46_04334	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUW46_04340	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUW46_04354	COG1136	(ABC) transporter
HUW46_04354	COG0577	efflux transmembrane transporter activity
HUW46_04356	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW46_04357	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUW46_04359	COG0667	Aldo Keto reductase
HUW46_04363	COG1522	sequence-specific DNA binding
HUW46_04370	COG0515	serine threonine protein kinase
HUW46_04370	COG2815	serine threonine protein kinase
HUW46_04375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW46_04376	COG0596	Alpha beta hydrolase
HUW46_04384	COG3903	Transcriptional regulator
HUW46_04384	COG3629	intracellular signal transduction
HUW46_04391	COG0596	Alpha beta hydrolase
HUW46_04398	COG0574	Belongs to the PEP-utilizing enzyme family
HUW46_04398	COG3848	Pyruvate phosphate dikinase
HUW46_04414	COG0210	DNA helicase
HUW46_04415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW46_04422	COG3706	GGDEF domain
HUW46_04427	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW46_04450	COG0714	Associated with various cellular activities
HUW46_04477	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HUW46_04480	COG0270	DNA (cytosine-5-)-methyltransferase activity
HUW46_04485	COG4974	Belongs to the 'phage' integrase family
HUW46_04493	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04509	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW46_04515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW46_04531	COG0494	nUDIX hydrolase
HUW46_04596	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW46_04598	COG0477	Major facilitator Superfamily
HUW46_04607	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_04609	COG4977	sequence-specific DNA binding
HUW46_04610	COG2197	response regulator
HUW46_04614	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW46_04615	COG1595	DNA-templated transcription, initiation
HUW46_04616	COG2169	Transcriptional regulator
HUW46_04616	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW46_04625	COG4585	Histidine kinase
HUW46_04626	COG2197	response regulator
HUW46_04629	COG1309	transcriptional regulator
HUW46_04635	COG1216	Glycosyl transferase, family 2
HUW46_04640	COG2072	flavoprotein involved in K transport
HUW46_04641	COG4221	oxidoreductase activity
HUW46_04649	COG2814	Major facilitator Superfamily
HUW46_04655	COG0515	serine threonine protein kinase
HUW46_04657	COG1132	(ABC) transporter
HUW46_04658	COG1132	(ABC) transporter
HUW46_04660	COG3321	synthase
HUW46_04660	COG0604	alcohol dehydrogenase
HUW46_04661	COG2723	6-phospho-beta-galactosidase activity
HUW46_04663	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04669	COG1278	Cold shock
HUW46_04672	COG1595	DNA-templated transcription, initiation
HUW46_04677	COG0515	serine threonine protein kinase
HUW46_04681	COG2197	response regulator
HUW46_04682	COG4585	Histidine kinase
HUW46_04686	COG0154	amidase activity
HUW46_04688	COG1937	Protein conserved in bacteria
HUW46_04690	COG0028	Belongs to the TPP enzyme family
HUW46_04691	COG1454	alcohol dehydrogenase
HUW46_04699	COG1024	Enoyl-CoA hydratase
HUW46_04702	COG1414	Transcriptional regulator
HUW46_04707	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUW46_04719	COG2197	response regulator
HUW46_04723	COG0745	RESPONSE REGULATOR receiver
HUW46_04724	COG2205	protein histidine kinase activity
HUW46_04727	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUW46_04728	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUW46_04729	COG0583	DNA-binding transcription factor activity
HUW46_04736	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW46_04737	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUW46_04738	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUW46_04739	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW46_04740	COG0747	negative chemotaxis
HUW46_04741	COG0601	transmembrane transport
HUW46_04742	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_04744	COG4608	Belongs to the ABC transporter superfamily
HUW46_04751	COG0697	spore germination
HUW46_04752	COG0583	DNA-binding transcription factor activity
HUW46_04756	COG0300	oxidoreductase activity
HUW46_04757	COG0583	DNA-binding transcription factor activity
HUW46_04763	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUW46_04765	COG1690	Belongs to the RtcB family
HUW46_04768	COG0583	DNA-binding transcription factor activity
HUW46_04775	COG0657	acetylesterase activity
HUW46_04777	COG1764	response to oxidative stress
HUW46_04778	COG0783	Belongs to the Dps family
HUW46_04779	COG2267	carboxylic ester hydrolase activity
HUW46_04780	COG0076	glutamate decarboxylase activity
HUW46_04781	COG1902	pentaerythritol trinitrate reductase activity
HUW46_04786	COG1408	metallophosphoesterase
HUW46_04787	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW46_04807	COG0596	Alpha beta hydrolase
HUW46_04809	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUW46_04810	COG3104	oligopeptide transport
HUW46_04817	COG4977	sequence-specific DNA binding
HUW46_04822	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW46_04824	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUW46_04826	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUW46_04827	COG1737	Transcriptional regulator
HUW46_04828	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW46_04829	COG3876	Protein conserved in bacteria
HUW46_04830	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW46_04840	COG1111	helicase
HUW46_04840	COG1205	dead DEAH box helicase
HUW46_04841	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUW46_04845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUW46_04845	COG1754	DNA topoisomerase type I activity
HUW46_04848	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUW46_04849	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW46_04852	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW46_04856	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW46_04858	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUW46_04859	COG2027	D-alanyl-D-alanine carboxypeptidase
HUW46_04861	COG0037	tRNA processing
HUW46_04867	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW46_04868	COG0302	gtp cyclohydrolase
HUW46_04869	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUW46_04876	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUW46_04877	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUW46_04878	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUW46_04879	COG2076	Multidrug Resistance protein
HUW46_04881	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW46_04886	COG4941	Belongs to the sigma-70 factor family
HUW46_04896	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW46_04899	COG0596	Alpha beta hydrolase
HUW46_04902	COG1194	a g-specific adenine glycosylase
HUW46_04904	COG1609	Transcriptional regulator
HUW46_04906	COG1121	(ABC) transporter
HUW46_04907	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUW46_04909	COG4399	Belongs to the UPF0754 family
HUW46_04912	COG2814	Major facilitator Superfamily
HUW46_04913	COG1349	DNA-binding transcription factor activity
HUW46_04914	COG0406	alpha-ribazole phosphatase activity
HUW46_04915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW46_04916	COG2376	Dihydroxyacetone kinase
HUW46_04917	COG0698	ribose 5-phosphate isomerase
HUW46_04918	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW46_04921	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04924	COG2197	response regulator
HUW46_04928	COG0215	cysteine-tRNA ligase activity
HUW46_04929	COG0546	phosphoglycolate phosphatase activity
HUW46_04931	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUW46_04932	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW46_04933	COG1329	Transcriptional regulator
HUW46_04934	COG2847	Copper chaperone PCu(A)C
HUW46_04935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUW46_04937	COG1595	DNA-templated transcription, initiation
HUW46_04939	COG1309	transcriptional regulator
HUW46_04944	COG0577	efflux transmembrane transporter activity
HUW46_04944	COG1136	(ABC) transporter
HUW46_04948	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUW46_04955	COG1090	epimerase
HUW46_04956	COG1595	DNA-templated transcription, initiation
HUW46_04957	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUW46_04962	COG4941	Belongs to the sigma-70 factor family
HUW46_04967	COG1832	CoA-binding protein
HUW46_04970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUW46_04980	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_04981	COG0477	Major facilitator Superfamily
HUW46_04982	COG0129	dihydroxy-acid dehydratase activity
HUW46_04991	COG1846	Transcriptional regulator
HUW46_04992	COG0346	lactoylglutathione lyase activity
HUW46_04993	COG0400	carboxylic ester hydrolase activity
HUW46_04994	COG5416	Lipopolysaccharide assembly protein A domain
HUW46_04996	COG4399	Belongs to the UPF0754 family
HUW46_04997	COG0456	acetyltransferase
HUW46_04999	COG1917	Cupin 2, conserved barrel domain protein
HUW46_05000	COG5285	phytanoyl-CoA dioxygenase
HUW46_05003	COG3903	Transcriptional regulator
HUW46_05003	COG3629	intracellular signal transduction
HUW46_05010	COG2971	BadF BadG BcrA BcrD
HUW46_05011	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW46_05012	COG2188	Transcriptional regulator
HUW46_05014	COG3835	regulator
HUW46_05019	COG0352	thiamine-phosphate diphosphorylase activity
HUW46_05020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_05020	COG2022	thiamine diphosphate biosynthetic process
HUW46_05022	COG2022	thiamine diphosphate biosynthetic process
HUW46_05023	COG1846	Transcriptional regulator
HUW46_05028	COG0351	phosphomethylpyrimidine kinase
HUW46_05029	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUW46_05031	COG0242	peptide deformylase activity
HUW46_05036	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW46_05038	COG0688	phosphatidylethanolamine metabolic process
HUW46_05040	COG2261	transglycosylase associated protein
HUW46_05044	COG1278	Cold shock
HUW46_05046	COG0459	protein refolding
HUW46_05056	COG4948	Mandelate Racemase Muconate Lactonizing
HUW46_05057	COG0693	protein deglycase activity
HUW46_05065	COG1061	Type III restriction enzyme res subunit
HUW46_05067	COG1309	transcriptional regulator
HUW46_05071	COG0765	amino acid transport
HUW46_05073	COG0765	amino acid transport
HUW46_05076	COG2018	Roadblock/LC7 domain
HUW46_05079	COG2018	Roadblock/LC7 domain
HUW46_05090	COG1846	Transcriptional regulator
HUW46_05102	COG3304	Inner membrane component domain
HUW46_05109	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_05110	COG2197	response regulator
HUW46_05111	COG4585	Histidine kinase
HUW46_05112	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW46_05114	COG0546	phosphoglycolate phosphatase activity
HUW46_05116	COG1278	Cold shock
HUW46_05118	COG2814	Major facilitator Superfamily
HUW46_05123	COG2252	PERMEase
HUW46_05125	COG2814	Major facilitator Superfamily
HUW46_05128	COG5398	heme oxygenase
HUW46_05131	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW46_05141	COG2205	protein histidine kinase activity
HUW46_05142	COG0745	RESPONSE REGULATOR receiver
HUW46_05145	COG0577	efflux transmembrane transporter activity
HUW46_05145	COG1136	(ABC) transporter
HUW46_05153	COG2197	response regulator
HUW46_05158	COG0640	Transcriptional regulator
HUW46_05165	COG0831	urea catabolic process
HUW46_05166	COG0832	Belongs to the urease beta subunit family
HUW46_05167	COG0804	urea catabolic process
HUW46_05169	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUW46_05170	COG0829	nickel cation binding
HUW46_05172	COG0259	pyridoxamine-phosphate oxidase activity
HUW46_05178	COG1309	transcriptional regulator
HUW46_05179	COG2017	converts alpha-aldose to the beta-anomer
HUW46_05184	COG0456	acetyltransferase
HUW46_05184	COG0454	-acetyltransferase
HUW46_05188	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW46_05193	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUW46_05197	COG1802	Transcriptional regulator
HUW46_05198	COG1960	acyl-CoA dehydrogenase activity
HUW46_05200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW46_05202	COG0415	Belongs to the DNA photolyase family
HUW46_05203	COG1668	transmembrane transport
HUW46_05204	COG4152	abc transporter atp-binding protein
HUW46_05209	COG0277	FAD linked oxidase domain protein
HUW46_05216	COG0395	ABC-type sugar transport system, permease component
HUW46_05217	COG1175	transmembrane transport
HUW46_05218	COG2182	Extracellular solute-binding protein
HUW46_05221	COG1169	isochorismate synthase
HUW46_05223	COG1301	dicarboxylic acid transport
HUW46_05224	COG1960	acyl-CoA dehydrogenase activity
HUW46_05227	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_05228	COG1024	Enoyl-CoA hydratase
HUW46_05229	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUW46_05235	COG1321	iron dependent repressor
HUW46_05238	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW46_05242	COG2267	carboxylic ester hydrolase activity
HUW46_05243	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_05252	COG4941	Belongs to the sigma-70 factor family
HUW46_05253	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUW46_05254	COG1136	(ABC) transporter
HUW46_05254	COG0577	efflux transmembrane transporter activity
HUW46_05255	COG0577	efflux transmembrane transporter activity
HUW46_05255	COG1136	(ABC) transporter
HUW46_05256	COG4585	Histidine kinase
HUW46_05257	COG2197	response regulator
HUW46_05259	COG0702	epimerase
HUW46_05260	COG1733	regulation of RNA biosynthetic process
HUW46_05266	COG1064	alcohol dehydrogenase
HUW46_05269	COG1309	transcriptional regulator
HUW46_05272	COG3537	Alpha-1,2-mannosidase
HUW46_05273	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW46_05274	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_05274	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_05279	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_05280	COG5001	Diguanylate cyclase
HUW46_05282	COG2124	cytochrome p450
HUW46_05288	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW46_05289	COG4279	zinc finger
HUW46_05304	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUW46_05305	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUW46_05311	COG2860	membrane
HUW46_05313	COG2205	protein histidine kinase activity
HUW46_05314	COG1349	DNA-binding transcription factor activity
HUW46_05316	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW46_05325	COG0745	RESPONSE REGULATOR receiver
HUW46_05326	COG5002	protein histidine kinase activity
HUW46_05328	COG0315	cyclic pyranopterin monophosphate synthase activity
HUW46_05328	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUW46_05331	COG1970	mechanosensitive ion channel activity
HUW46_05335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW46_05336	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUW46_05348	COG2936	dipeptidyl-peptidase activity
HUW46_05349	COG2133	pyrroloquinoline quinone binding
HUW46_05349	COG5183	chlorophyll binding
HUW46_05354	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_05356	COG2258	MOSC domain
HUW46_05366	COG0515	serine threonine protein kinase
HUW46_05392	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW46_05393	COG0084	hydrolase, TatD family'
HUW46_05394	COG3583	domain protein
HUW46_05396	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUW46_05397	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUW46_05398	COG0488	(ABC) transporter
HUW46_05399	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_05403	COG0193	aminoacyl-tRNA hydrolase activity
HUW46_05410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW46_05416	COG2133	pyrroloquinoline quinone binding
HUW46_05426	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_05431	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW46_05431	COG1902	pentaerythritol trinitrate reductase activity
HUW46_05434	COG4941	Belongs to the sigma-70 factor family
HUW46_05435	COG3795	YCII-related domain
HUW46_05439	COG0702	epimerase
HUW46_05440	COG1733	regulation of RNA biosynthetic process
HUW46_05443	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_05444	COG2837	iron assimilation
HUW46_05446	COG0672	)-iron permease
HUW46_05452	COG0148	phosphopyruvate hydratase activity
HUW46_05458	COG0601	transmembrane transport
HUW46_05459	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_05461	COG4608	Belongs to the ABC transporter superfamily
HUW46_05464	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUW46_05467	COG1252	NADH dehydrogenase
HUW46_05483	COG1131	(ABC) transporter
HUW46_05488	COG1309	transcriptional regulator
HUW46_05489	COG0657	acetylesterase activity
HUW46_05490	COG0583	DNA-binding transcription factor activity
HUW46_05493	COG1396	sequence-specific DNA binding
HUW46_05497	COG3795	YCII-related domain
HUW46_05498	COG4941	Belongs to the sigma-70 factor family
HUW46_05501	COG0583	DNA-binding transcription factor activity
HUW46_05502	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_05505	COG2197	response regulator
HUW46_05506	COG4585	Histidine kinase
HUW46_05507	COG1131	(ABC) transporter
HUW46_05509	COG4941	Belongs to the sigma-70 factor family
HUW46_05512	COG0745	RESPONSE REGULATOR receiver
HUW46_05513	COG2205	protein histidine kinase activity
HUW46_05515	COG0714	Associated with various cellular activities
HUW46_05521	COG0488	(ABC) transporter
HUW46_05535	COG2391	methyltransferase activity
HUW46_05536	COG0477	Major facilitator Superfamily
HUW46_05537	COG3655	Transcriptional regulator
HUW46_05539	COG0183	Belongs to the thiolase family
HUW46_05546	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUW46_05547	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUW46_05549	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_05550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW46_05552	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUW46_05554	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUW46_05556	COG1331	Highly conserved protein containing a thioredoxin domain
HUW46_05561	COG0477	Major facilitator Superfamily
HUW46_05565	COG0546	phosphoglycolate phosphatase activity
HUW46_05570	COG0477	Major facilitator Superfamily
HUW46_05572	COG1316	TRANSCRIPTIONal
HUW46_05577	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUW46_05580	COG0513	Belongs to the DEAD box helicase family
HUW46_05581	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_05584	COG1793	dna ligase
HUW46_05591	COG0667	Aldo Keto reductase
HUW46_05596	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_05597	COG0114	fumarate hydratase activity
HUW46_05598	COG0492	ferredoxin-NADP+ reductase activity
HUW46_05601	COG1722	exodeoxyribonuclease VII activity
HUW46_05603	COG1570	exodeoxyribonuclease VII activity
HUW46_05605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW46_05608	COG0420	3'-5' exonuclease activity
HUW46_05609	COG0419	ATPase involved in DNA repair
HUW46_05614	COG0012	GTP binding
HUW46_05615	COG1192	Involved in chromosome partitioning
HUW46_05618	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUW46_05619	COG4143	(ABC) transporter
HUW46_05621	COG3842	ATPase activity
HUW46_05622	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW46_05625	COG1131	(ABC) transporter
HUW46_05630	COG0180	Tryptophanyl-tRNA synthetase
HUW46_05633	COG1217	gtp-binding protein TYPA
HUW46_05634	COG0747	negative chemotaxis
HUW46_05637	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_05638	COG0789	Transcriptional regulator
HUW46_05649	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUW46_05654	COG4977	sequence-specific DNA binding
HUW46_05657	COG1994	Peptidase M50
HUW46_05662	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW46_05663	COG2835	tetraacyldisaccharide 4'-kinase activity
HUW46_05667	COG3629	intracellular signal transduction
HUW46_05667	COG3903	Transcriptional regulator
HUW46_05669	COG0531	amino acid
HUW46_05671	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUW46_05674	COG1846	Transcriptional regulator
HUW46_05675	COG2382	esterase
HUW46_05680	COG2146	nitrite reductase [NAD(P)H] activity
HUW46_05681	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW46_05682	COG0706	membrane insertase activity
HUW46_05684	COG0745	RESPONSE REGULATOR receiver
HUW46_05685	COG5002	protein histidine kinase activity
HUW46_05685	COG5000	phosphorelay sensor kinase activity
HUW46_05688	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUW46_05689	COG0653	protein targeting
HUW46_05692	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW46_05696	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUW46_05696	COG0506	proline dehydrogenase activity
HUW46_05696	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUW46_05700	COG1162	GTPase activity
HUW46_05701	COG2135	peptidase activity
HUW46_05705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUW46_05708	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUW46_05711	COG1597	lipid kinase activity
HUW46_05714	COG0406	alpha-ribazole phosphatase activity
HUW46_05717	COG1522	sequence-specific DNA binding
HUW46_05718	COG0477	Major facilitator Superfamily
HUW46_05719	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HUW46_05723	COG1174	glycine betaine transport
HUW46_05724	COG1174	glycine betaine transport
HUW46_05727	COG2205	protein histidine kinase activity
HUW46_05728	COG0745	RESPONSE REGULATOR receiver
HUW46_05744	COG0567	Dehydrogenase, E1 component
HUW46_05744	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW46_05746	COG3209	COG3209 Rhs family protein
HUW46_05746	COG3209	COG3209 Rhs family protein
HUW46_05751	COG1132	(ABC) transporter
HUW46_05754	COG0686	Belongs to the AlaDH PNT family
HUW46_05757	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HUW46_05757	COG2508	Transcriptional regulator
HUW46_05759	COG1695	Transcriptional regulator
HUW46_05760	COG0346	lactoylglutathione lyase activity
HUW46_05762	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUW46_05767	COG2755	lipolytic protein G-D-S-L family
HUW46_05768	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW46_05770	COG1960	acyl-CoA dehydrogenase activity
HUW46_05774	COG2814	Major facilitator Superfamily
HUW46_05776	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_05778	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HUW46_05779	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUW46_05780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUW46_05782	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUW46_05783	COG1960	acyl-CoA dehydrogenase activity
HUW46_05786	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_05787	COG0583	DNA-binding transcription factor activity
HUW46_05788	COG1309	transcriptional regulator
HUW46_05789	COG0183	Belongs to the thiolase family
HUW46_05790	COG1024	Enoyl-CoA hydratase
HUW46_05790	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_05791	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW46_05794	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUW46_05795	COG0028	Belongs to the TPP enzyme family
HUW46_05800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUW46_05802	COG0473	3-isopropylmalate dehydrogenase activity
HUW46_05809	COG0154	amidase activity
HUW46_05810	COG0667	Aldo Keto reductase
HUW46_05816	COG2133	pyrroloquinoline quinone binding
HUW46_05818	COG0435	Glutathione S-transferase
HUW46_05819	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_05826	COG3345	alpha-galactosidase
HUW46_05827	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_05833	COG0583	DNA-binding transcription factor activity
HUW46_05834	COG0596	Alpha beta hydrolase
HUW46_05836	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW46_05837	COG1215	transferase activity, transferring glycosyl groups
HUW46_05844	COG0702	epimerase
HUW46_05845	COG0326	Molecular chaperone. Has ATPase activity
HUW46_05849	COG0653	protein targeting
HUW46_05850	COG0583	DNA-binding transcription factor activity
HUW46_05852	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_05856	COG3634	alkyl hydroperoxide reductase activity
HUW46_05873	COG1819	glycosyl
HUW46_05874	COG1309	transcriptional regulator
HUW46_05879	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUW46_05880	COG2319	Wd-40 repeat
HUW46_05880	COG4249	Peptidase C14 caspase catalytic subunit p20
HUW46_05888	COG0475	glutathione-regulated potassium exporter activity
HUW46_05891	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW46_05893	COG1960	acyl-CoA dehydrogenase activity
HUW46_05894	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_05896	COG3629	intracellular signal transduction
HUW46_05896	COG3903	Transcriptional regulator
HUW46_05897	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_05900	COG1960	acyl-CoA dehydrogenase activity
HUW46_05902	COG3433	isochorismatase activity
HUW46_05902	COG2226	methyltransferase
HUW46_05902	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_05905	COG2197	response regulator
HUW46_05906	COG1309	transcriptional regulator
HUW46_05919	COG1132	(ABC) transporter
HUW46_05922	COG2197	response regulator
HUW46_05935	COG2267	carboxylic ester hydrolase activity
HUW46_05942	COG0018	arginyl-trna synthetase
HUW46_05943	COG0019	diaminopimelate decarboxylase activity
HUW46_05944	COG0460	homoserine dehydrogenase
HUW46_05945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUW46_05946	COG0083	homoserine kinase activity
HUW46_05947	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUW46_05947	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUW46_05949	COG0254	rRNA binding
HUW46_05950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW46_05953	COG0789	Transcriptional regulator
HUW46_05954	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW46_05956	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW46_05957	COG0492	ferredoxin-NADP+ reductase activity
HUW46_05964	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_05966	COG0356	it plays a direct role in the translocation of protons across the membrane
HUW46_05967	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW46_05968	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUW46_05969	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW46_05971	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUW46_05972	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUW46_05973	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUW46_05977	COG4941	Belongs to the sigma-70 factor family
HUW46_05978	COG0667	Aldo Keto reductase
HUW46_05987	COG0477	Major facilitator Superfamily
HUW46_05989	COG1280	lysine exporter protein (LysE YggA)
HUW46_05991	COG1280	lysine exporter protein (LysE YggA)
HUW46_05992	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW46_05992	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW46_05993	COG1024	Enoyl-CoA hydratase
HUW46_05995	COG0702	epimerase
HUW46_05999	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUW46_06003	COG2376	Dihydroxyacetone kinase
HUW46_06008	COG1131	(ABC) transporter
HUW46_06010	COG4585	Histidine kinase
HUW46_06011	COG2197	response regulator
HUW46_06017	COG2267	carboxylic ester hydrolase activity
HUW46_06018	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUW46_06026	COG0800	Aldolase
HUW46_06027	COG1335	isochorismatase
HUW46_06028	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW46_06029	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUW46_06031	COG3191	aminopeptidase activity
HUW46_06036	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUW46_06037	COG1234	tRNA 3'-trailer cleavage
HUW46_06039	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUW46_06040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW46_06052	COG1316	TRANSCRIPTIONal
HUW46_06055	COG3629	intracellular signal transduction
HUW46_06055	COG3903	Transcriptional regulator
HUW46_06057	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06059	COG3844	kynureninase activity
HUW46_06062	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW46_06064	COG1796	DNA polymerase
HUW46_06064	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW46_06065	COG1295	ribonuclease BN
HUW46_06075	COG2197	response regulator
HUW46_06080	COG0477	Major facilitator Superfamily
HUW46_06088	COG0154	amidase activity
HUW46_06091	COG1309	transcriptional regulator
HUW46_06096	COG0243	molybdopterin cofactor binding
HUW46_06098	COG1396	sequence-specific DNA binding
HUW46_06106	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW46_06113	COG2124	cytochrome p450
HUW46_06121	COG0366	Alpha amylase catalytic
HUW46_06122	COG0366	Alpha amylase catalytic
HUW46_06124	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUW46_06125	COG0297	glycogen (starch) synthase activity
HUW46_06127	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06134	COG4935	Belongs to the peptidase S8 family
HUW46_06134	COG2234	aminopeptidase activity
HUW46_06137	COG0745	RESPONSE REGULATOR receiver
HUW46_06138	COG2205	protein histidine kinase activity
HUW46_06141	COG2080	2 iron, 2 sulfur cluster binding
HUW46_06142	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW46_06142	COG2010	Cytochrome c
HUW46_06143	COG2508	Transcriptional regulator
HUW46_06147	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06155	COG3629	intracellular signal transduction
HUW46_06155	COG3903	Transcriptional regulator
HUW46_06160	COG0346	lactoylglutathione lyase activity
HUW46_06161	COG0183	Belongs to the thiolase family
HUW46_06164	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_06165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW46_06166	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW46_06167	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUW46_06170	COG2205	protein histidine kinase activity
HUW46_06171	COG0745	RESPONSE REGULATOR receiver
HUW46_06174	COG0531	amino acid
HUW46_06175	COG3629	intracellular signal transduction
HUW46_06175	COG3903	Transcriptional regulator
HUW46_06176	COG3903	Transcriptional regulator
HUW46_06176	COG3629	intracellular signal transduction
HUW46_06184	COG0464	growth
HUW46_06186	COG0443	Heat shock 70 kDa protein
HUW46_06187	COG1674	ftsk spoiiie
HUW46_06188	COG1404	Belongs to the peptidase S8 family
HUW46_06201	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW46_06203	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW46_06205	COG3279	Response regulator of the LytR AlgR family
HUW46_06206	COG3275	phosphorelay sensor kinase activity
HUW46_06217	COG1309	transcriptional regulator
HUW46_06219	COG1879	ABC-type sugar transport system periplasmic component
HUW46_06220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW46_06223	COG1609	Transcriptional regulator
HUW46_06224	COG3537	Alpha-1,2-mannosidase
HUW46_06225	COG3537	Alpha-1,2-mannosidase
HUW46_06228	COG2124	cytochrome p450
HUW46_06232	COG1846	Transcriptional regulator
HUW46_06239	COG0058	SHG alpha-glucan phosphorylase activity
HUW46_06249	COG0745	RESPONSE REGULATOR receiver
HUW46_06250	COG2205	protein histidine kinase activity
HUW46_06252	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_06255	COG0596	Alpha beta hydrolase
HUW46_06259	COG3345	alpha-galactosidase
HUW46_06260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUW46_06261	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUW46_06262	COG0444	Belongs to the ABC transporter superfamily
HUW46_06263	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUW46_06264	COG1461	Dihydroxyacetone kinase
HUW46_06266	COG1309	transcriptional regulator
HUW46_06269	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUW46_06274	COG3835	regulator
HUW46_06283	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUW46_06288	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW46_06290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_06291	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW46_06292	COG3973	AAA domain
HUW46_06293	COG0742	ribosomal rna small subunit methyltransferase
HUW46_06294	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW46_06298	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUW46_06299	COG0571	ribonuclease III activity
HUW46_06300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW46_06306	COG0367	asparagine synthase
HUW46_06308	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUW46_06309	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUW46_06310	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUW46_06314	COG1254	Belongs to the acylphosphatase family
HUW46_06318	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW46_06319	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUW46_06324	COG1414	Transcriptional regulator
HUW46_06325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUW46_06327	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUW46_06328	COG3835	regulator
HUW46_06332	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW46_06333	COG0590	tRNA wobble adenosine to inosine editing
HUW46_06334	COG2252	PERMEase
HUW46_06337	COG3795	YCII-related domain
HUW46_06338	COG4941	Belongs to the sigma-70 factor family
HUW46_06344	COG2814	Major facilitator Superfamily
HUW46_06348	COG2233	PERMEase
HUW46_06353	COG3622	Belongs to the hyi family
HUW46_06354	COG2084	Dehydrogenase
HUW46_06355	COG3960	tartronate-semialdehyde synthase activity
HUW46_06356	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW46_06357	COG4266	Belongs to the allantoicase family
HUW46_06360	COG1832	CoA-binding protein
HUW46_06365	COG0667	Aldo Keto reductase
HUW46_06370	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUW46_06372	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUW46_06375	COG1132	(ABC) transporter
HUW46_06380	COG0228	four-way junction DNA binding
HUW46_06384	COG0336	Belongs to the RNA methyltransferase TrmD family
HUW46_06385	COG0335	large ribosomal subunit rRNA binding
HUW46_06386	COG0681	Belongs to the peptidase S26 family
HUW46_06387	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUW46_06389	COG0792	nuclease activity
HUW46_06393	COG1191	sigma factor activity
HUW46_06395	COG0052	Belongs to the universal ribosomal protein uS2 family
HUW46_06396	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUW46_06397	COG0528	UMP kinase activity
HUW46_06398	COG0233	cytoplasmic translational termination
HUW46_06400	COG0477	Major facilitator Superfamily
HUW46_06406	COG0583	DNA-binding transcription factor activity
HUW46_06407	COG5006	permease, DMT superfamily
HUW46_06408	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUW46_06409	COG4691	Plasmid stability protein
HUW46_06410	COG1487	ribonuclease activity
HUW46_06414	COG2267	carboxylic ester hydrolase activity
HUW46_06415	COG1510	regulation of RNA biosynthetic process
HUW46_06416	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HUW46_06418	COG1802	Transcriptional regulator
HUW46_06422	COG0596	Alpha beta hydrolase
HUW46_06423	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_06425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW46_06425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW46_06428	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_06431	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUW46_06433	COG2197	response regulator
HUW46_06445	COG3629	intracellular signal transduction
HUW46_06445	COG3903	Transcriptional regulator
HUW46_06464	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW46_06464	COG1672	PFAM Archaeal ATPase
HUW46_06468	COG1785	Belongs to the alkaline phosphatase family
HUW46_06471	COG2814	Major facilitator Superfamily
HUW46_06472	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW46_06475	COG0750	zinc metalloprotease
HUW46_06476	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUW46_06479	COG0456	acetyltransferase
HUW46_06481	COG0454	-acetyltransferase
HUW46_06481	COG0456	acetyltransferase
HUW46_06484	COG2186	Transcriptional regulator
HUW46_06485	COG2807	transmembrane transport
HUW46_06492	COG0513	Belongs to the DEAD box helicase family
HUW46_06494	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW46_06494	COG1672	PFAM Archaeal ATPase
HUW46_06495	COG1404	Belongs to the peptidase S8 family
HUW46_06499	COG3022	response to hydroperoxide
HUW46_06503	COG1414	Transcriptional regulator
HUW46_06505	COG0442	prolyl-tRNA aminoacylation
HUW46_06508	COG3328	transposase activity
HUW46_06511	COG4585	Histidine kinase
HUW46_06512	COG2197	response regulator
HUW46_06518	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW46_06518	COG1902	pentaerythritol trinitrate reductase activity
HUW46_06524	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUW46_06527	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW46_06532	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_06533	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW46_06536	COG4152	abc transporter atp-binding protein
HUW46_06537	COG1668	transmembrane transport
HUW46_06538	COG0668	transmembrane transport
HUW46_06539	COG3201	nicotinamide mononucleotide transporter
HUW46_06541	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUW46_06548	COG3340	Belongs to the peptidase S51 family
HUW46_06553	COG2814	Major facilitator Superfamily
HUW46_06561	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_06562	COG1104	cysteine desulfurase activity
HUW46_06567	COG1113	amino acid transport
HUW46_06569	COG3537	Alpha-1,2-mannosidase
HUW46_06570	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06572	COG0587	DNA-directed DNA polymerase activity
HUW46_06575	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06580	COG5002	protein histidine kinase activity
HUW46_06580	COG3850	Histidine kinase
HUW46_06582	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW46_06583	COG1376	ErfK ybiS ycfS ynhG family protein
HUW46_06587	COG0586	Pfam SNARE associated Golgi protein
HUW46_06588	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUW46_06594	COG3250	beta-galactosidase activity
HUW46_06595	COG0321	lipoyl(octanoyl) transferase activity
HUW46_06598	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW46_06599	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW46_06601	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUW46_06602	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUW46_06608	COG0107	imidazoleglycerol-phosphate synthase activity
HUW46_06611	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW46_06613	COG0134	indole-3-glycerol-phosphate synthase activity
HUW46_06614	COG0133	tryptophan synthase activity
HUW46_06615	COG0159	tryptophan synthase activity
HUW46_06617	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUW46_06622	COG1120	ATPase activity
HUW46_06623	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_06625	COG0067	glutamate synthase
HUW46_06625	COG0069	glutamate synthase activity
HUW46_06625	COG0070	glutamate synthase
HUW46_06628	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUW46_06630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUW46_06631	COG0066	3-isopropylmalate dehydratase activity
HUW46_06633	COG3629	intracellular signal transduction
HUW46_06633	COG3903	Transcriptional regulator
HUW46_06634	COG0494	nUDIX hydrolase
HUW46_06634	COG0406	alpha-ribazole phosphatase activity
HUW46_06636	COG1920	GTP binding
HUW46_06638	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUW46_06642	COG1119	ATPase activity
HUW46_06643	COG1024	Enoyl-CoA hydratase
HUW46_06644	COG2226	methyltransferase
HUW46_06647	COG3979	chitinase
HUW46_06649	COG3473	Maleate cis-trans isomerase
HUW46_06650	COG0583	DNA-binding transcription factor activity
HUW46_06651	COG1335	isochorismatase
HUW46_06663	COG0596	Alpha beta hydrolase
HUW46_06665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_06666	COG1126	abc transporter atp-binding protein
HUW46_06667	COG0765	amino acid transport
HUW46_06668	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW46_06682	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06683	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUW46_06690	COG0640	Transcriptional regulator
HUW46_06692	COG4106	trans-aconitate 2-methyltransferase activity
HUW46_06697	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW46_06698	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_06700	COG1335	isochorismatase
HUW46_06712	COG1733	regulation of RNA biosynthetic process
HUW46_06721	COG0596	Alpha beta hydrolase
HUW46_06723	COG3629	intracellular signal transduction
HUW46_06723	COG3903	Transcriptional regulator
HUW46_06730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW46_06733	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06736	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW46_06744	COG0477	Major facilitator Superfamily
HUW46_06753	COG4585	Histidine kinase
HUW46_06754	COG2197	response regulator
HUW46_06755	COG0791	NLP P60 protein
HUW46_06755	COG1388	LysM domain
HUW46_06755	COG3103	Sh3 type 3 domain protein
HUW46_06757	COG0110	maltose O-acetyltransferase activity
HUW46_06760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUW46_06764	COG3706	GGDEF domain
HUW46_06766	COG1309	transcriptional regulator
HUW46_06768	COG3250	beta-galactosidase activity
HUW46_06769	COG2017	converts alpha-aldose to the beta-anomer
HUW46_06770	COG0386	Belongs to the glutathione peroxidase family
HUW46_06772	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW46_06774	COG1307	EDD domain protein, DegV family
HUW46_06776	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUW46_06779	COG0583	DNA-binding transcription factor activity
HUW46_06780	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06784	COG0482	sulfurtransferase activity
HUW46_06788	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_06793	COG2409	Drug exporters of the RND superfamily
HUW46_06795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUW46_06795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW46_06798	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW46_06804	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW46_06805	COG0154	amidase activity
HUW46_06810	COG1414	Transcriptional regulator
HUW46_06816	COG1609	Transcriptional regulator
HUW46_06817	COG0673	inositol 2-dehydrogenase activity
HUW46_06819	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUW46_06828	COG0583	DNA-binding transcription factor activity
HUW46_06829	COG0148	phosphopyruvate hydratase activity
HUW46_06831	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_06832	COG3321	synthase
HUW46_06832	COG0604	alcohol dehydrogenase
HUW46_06834	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUW46_06846	COG1733	regulation of RNA biosynthetic process
HUW46_06859	COG0604	alcohol dehydrogenase
HUW46_06859	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_06859	COG3321	synthase
HUW46_06867	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_06870	COG2814	Major facilitator Superfamily
HUW46_06871	COG1733	regulation of RNA biosynthetic process
HUW46_06879	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW46_06880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUW46_06883	COG1846	Transcriptional regulator
HUW46_06884	COG0640	Transcriptional regulator
HUW46_06887	COG1132	(ABC) transporter
HUW46_06888	COG3250	beta-galactosidase activity
HUW46_06890	COG1609	Transcriptional regulator
HUW46_06891	COG2223	nitrite transmembrane transporter activity
HUW46_06894	COG0629	single-stranded DNA binding
HUW46_06897	COG2902	Dehydrogenase
HUW46_06903	COG0366	Alpha amylase catalytic
HUW46_06905	COG0668	transmembrane transport
HUW46_06909	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HUW46_06911	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUW46_06915	COG0698	ribose 5-phosphate isomerase
HUW46_06920	COG0791	NLP P60 protein
HUW46_06929	COG0477	Major facilitator Superfamily
HUW46_06932	COG3629	intracellular signal transduction
HUW46_06932	COG3903	Transcriptional regulator
HUW46_06942	COG0745	RESPONSE REGULATOR receiver
HUW46_06949	COG4166	transmembrane transport
HUW46_06957	COG0477	Major facilitator Superfamily
HUW46_06958	COG2267	carboxylic ester hydrolase activity
HUW46_06960	COG0434	BtpA family
HUW46_06962	COG1349	DNA-binding transcription factor activity
HUW46_06963	COG0531	amino acid
HUW46_06968	COG4948	Mandelate Racemase Muconate Lactonizing
HUW46_06969	COG2508	Transcriptional regulator
HUW46_06969	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HUW46_06972	COG0444	Belongs to the ABC transporter superfamily
HUW46_06973	COG0601	transmembrane transport
HUW46_06981	COG2197	response regulator
HUW46_06982	COG4585	Histidine kinase
HUW46_06986	COG0488	(ABC) transporter
HUW46_06988	COG1672	PFAM Archaeal ATPase
HUW46_06988	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW46_06993	COG1309	transcriptional regulator
HUW46_07000	COG3537	Alpha-1,2-mannosidase
HUW46_07010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_07011	COG1309	transcriptional regulator
HUW46_07015	COG2313	pseudouridylate synthase activity
HUW46_07020	COG4213	ABC transporter substrate-binding protein
HUW46_07022	COG4214	carbohydrate transport
HUW46_07025	COG0531	amino acid
HUW46_07026	COG2197	response regulator
HUW46_07032	COG1940	carbohydrate kinase activity
HUW46_07033	COG0483	inositol monophosphate 1-phosphatase activity
HUW46_07037	COG0756	dUTP diphosphatase activity
HUW46_07039	COG1280	lysine exporter protein (LysE YggA)
HUW46_07044	COG0569	domain protein
HUW46_07045	COG0531	amino acid
HUW46_07046	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW46_07049	COG4122	O-methyltransferase activity
HUW46_07052	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_07056	COG3226	Transcriptional regulator
HUW46_07064	COG1357	PFAM Pentapeptide repeats (8 copies)
HUW46_07069	COG2226	methyltransferase
HUW46_07070	COG1349	DNA-binding transcription factor activity
HUW46_07071	COG1070	Carbohydrate kinase
HUW46_07072	COG1879	ABC-type sugar transport system periplasmic component
HUW46_07073	COG1129	ABC transporter
HUW46_07074	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW46_07075	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW46_07076	COG3347	Dehydrogenase
HUW46_07076	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_07081	COG0531	amino acid
HUW46_07083	COG1070	Carbohydrate kinase
HUW46_07087	COG2267	carboxylic ester hydrolase activity
HUW46_07088	COG1653	transport
HUW46_07089	COG1175	transmembrane transport
HUW46_07090	COG0395	ABC-type sugar transport system, permease component
HUW46_07092	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUW46_07096	COG2197	response regulator
HUW46_07097	COG0009	L-threonylcarbamoyladenylate synthase
HUW46_07105	COG0640	Transcriptional regulator
HUW46_07106	COG1742	UPF0060 membrane protein
HUW46_07108	COG1309	transcriptional regulator
HUW46_07111	COG1793	dna ligase
HUW46_07116	COG0475	glutathione-regulated potassium exporter activity
HUW46_07118	COG2111	Na H antiporter
HUW46_07118	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW46_07119	COG2111	Na H antiporter
HUW46_07120	COG1006	Multisubunit Na H antiporter MnhC subunit
HUW46_07121	COG0651	ATP synthesis coupled electron transport
HUW46_07124	COG1320	monovalent cation:proton antiporter activity
HUW46_07125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW46_07127	COG1160	GTP binding
HUW46_07139	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW46_07140	COG1414	Transcriptional regulator
HUW46_07142	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW46_07143	COG4948	Mandelate Racemase Muconate Lactonizing
HUW46_07151	COG1793	dna ligase
HUW46_07151	COG3285	dna ligase
HUW46_07152	COG1609	Transcriptional regulator
HUW46_07153	COG0477	Major facilitator Superfamily
HUW46_07156	COG0667	Aldo Keto reductase
HUW46_07158	COG0604	alcohol dehydrogenase
HUW46_07158	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_07158	COG3321	synthase
HUW46_07160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_07161	COG0596	Alpha beta hydrolase
HUW46_07164	COG2828	Protein conserved in bacteria
HUW46_07177	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW46_07182	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUW46_07186	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_07197	COG0252	asparaginase activity
HUW46_07198	COG0542	response to heat
HUW46_07206	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUW46_07210	COG2837	iron assimilation
HUW46_07212	COG2169	Transcriptional regulator
HUW46_07216	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_07217	COG1454	alcohol dehydrogenase
HUW46_07233	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HUW46_07236	COG2188	Transcriptional regulator
HUW46_07237	COG1653	transport
HUW46_07238	COG1175	transmembrane transport
HUW46_07239	COG0395	ABC-type sugar transport system, permease component
HUW46_07240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUW46_07244	COG4941	Belongs to the sigma-70 factor family
HUW46_07250	COG0477	Major facilitator Superfamily
HUW46_07254	COG0667	Aldo Keto reductase
HUW46_07256	COG1501	Belongs to the glycosyl hydrolase 31 family
HUW46_07263	COG0384	phenazine biosynthesis protein PhzF
HUW46_07264	COG0277	FAD linked oxidase domain protein
HUW46_07269	COG1595	DNA-templated transcription, initiation
HUW46_07272	COG0028	Belongs to the TPP enzyme family
HUW46_07277	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_07286	COG0673	inositol 2-dehydrogenase activity
HUW46_07288	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW46_07289	COG1082	Xylose isomerase domain protein TIM barrel
HUW46_07294	COG1233	COG1233 Phytoene dehydrogenase and related
HUW46_07295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW46_07297	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_07312	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW46_07314	COG1309	transcriptional regulator
HUW46_07317	COG0745	RESPONSE REGULATOR receiver
HUW46_07318	COG2205	protein histidine kinase activity
HUW46_07323	COG1116	anion transmembrane transporter activity
HUW46_07324	COG3328	transposase activity
HUW46_07332	COG0069	glutamate synthase activity
HUW46_07340	COG0300	oxidoreductase activity
HUW46_07345	COG1960	acyl-CoA dehydrogenase activity
HUW46_07346	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_07347	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUW46_07355	COG0601	transmembrane transport
HUW46_07356	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_07357	COG0444	Belongs to the ABC transporter superfamily
HUW46_07359	COG3191	aminopeptidase activity
HUW46_07362	COG1609	Transcriptional regulator
HUW46_07367	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW46_07369	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUW46_07376	COG3604	Transcriptional regulator
HUW46_07378	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUW46_07386	COG4257	antibiotic catabolic process
HUW46_07389	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_07390	COG1535	isochorismatase
HUW46_07390	COG3433	isochorismatase activity
HUW46_07393	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_07394	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW46_07395	COG1120	ATPase activity
HUW46_07403	COG2318	DinB family
HUW46_07406	COG2124	cytochrome p450
HUW46_07407	COG0402	S-adenosylhomocysteine deaminase activity
HUW46_07415	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HUW46_07416	COG1140	nitrate reductase beta subunit
HUW46_07419	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUW46_07431	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_07432	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW46_07432	COG0617	tRNA 3'-terminal CCA addition
HUW46_07432	COG0517	IMP dehydrogenase activity
HUW46_07441	COG4585	Histidine kinase
HUW46_07442	COG2197	response regulator
HUW46_07444	COG1695	Transcriptional regulator
HUW46_07447	COG2205	protein histidine kinase activity
HUW46_07451	COG0242	peptide deformylase activity
HUW46_07455	COG0702	epimerase
HUW46_07464	COG1131	(ABC) transporter
HUW46_07466	COG0745	RESPONSE REGULATOR receiver
HUW46_07467	COG2205	protein histidine kinase activity
HUW46_07469	COG0531	amino acid
HUW46_07472	COG3511	phospholipase C
HUW46_07478	COG1024	Enoyl-CoA hydratase
HUW46_07484	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_07485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_07486	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_07488	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW46_07489	COG0159	tryptophan synthase activity
HUW46_07490	COG0662	Cupin 2, conserved barrel domain protein
HUW46_07491	COG1960	acyl-CoA dehydrogenase activity
HUW46_07493	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HUW46_07494	COG0135	phosphoribosylanthranilate isomerase activity
HUW46_07495	COG0134	indole-3-glycerol-phosphate synthase activity
HUW46_07496	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUW46_07497	COG0163	prenyltransferase activity
HUW46_07502	COG2814	Major facilitator Superfamily
HUW46_07506	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_07507	COG2197	response regulator
HUW46_07509	COG2124	cytochrome p450
HUW46_07510	COG3321	synthase
HUW46_07510	COG0604	alcohol dehydrogenase
HUW46_07518	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW46_07521	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_07525	COG0175	sulfate reduction
HUW46_07529	COG0156	8-amino-7-oxononanoate synthase activity
HUW46_07537	COG2855	membrane
HUW46_07542	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_07543	COG0583	DNA-binding transcription factor activity
HUW46_07544	COG1464	Belongs to the NlpA lipoprotein family
HUW46_07545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUW46_07546	COG2011	ABC-type metal ion transport system permease component
HUW46_07548	COG2850	peptidyl-arginine hydroxylation
HUW46_07550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_07555	COG3251	PFAM MbtH domain protein
HUW46_07556	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_07557	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_07557	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_07558	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_07559	COG0069	glutamate synthase activity
HUW46_07560	COG0017	Asparaginyl-tRNA synthetase
HUW46_07561	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_07563	COG2175	clavaminate synthase activity
HUW46_07565	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HUW46_07571	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW46_07573	COG3903	Transcriptional regulator
HUW46_07573	COG3629	intracellular signal transduction
HUW46_07583	COG0640	Transcriptional regulator
HUW46_07585	COG1132	(ABC) transporter
HUW46_07586	COG2201	protein-glutamate methylesterase activity
HUW46_07589	COG2197	response regulator
HUW46_07590	COG0681	Belongs to the peptidase S26 family
HUW46_07597	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUW46_07599	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUW46_07603	COG0667	Aldo Keto reductase
HUW46_07616	COG1846	Transcriptional regulator
HUW46_07617	COG0702	epimerase
HUW46_07621	COG1968	undecaprenyl-diphosphatase activity
HUW46_07634	COG3420	alginic acid biosynthetic process
HUW46_07635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW46_07639	COG0778	Nitroreductase
HUW46_07642	COG2353	YceI-like domain
HUW46_07646	COG0438	transferase activity, transferring glycosyl groups
HUW46_07648	COG3608	succinylglutamate desuccinylase aspartoacylase
HUW46_07648	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUW46_07650	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUW46_07651	COG1396	sequence-specific DNA binding
HUW46_07654	COG1522	sequence-specific DNA binding
HUW46_07655	COG0626	cystathionine gamma-synthase activity
HUW46_07656	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUW46_07657	COG0217	transcriptional regulatory protein
HUW46_07659	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUW46_07660	COG0632	four-way junction helicase activity
HUW46_07664	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUW46_07665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW46_07666	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW46_07673	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_07677	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUW46_07678	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_07679	COG1609	Transcriptional regulator
HUW46_07680	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_07683	COG1414	Transcriptional regulator
HUW46_07684	COG0747	negative chemotaxis
HUW46_07686	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_07688	COG0673	inositol 2-dehydrogenase activity
HUW46_07691	COG4948	Mandelate Racemase Muconate Lactonizing
HUW46_07695	COG2318	DinB family
HUW46_07709	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW46_07714	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUW46_07722	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW46_07722	COG2755	lipolytic protein G-D-S-L family
HUW46_07724	COG2205	protein histidine kinase activity
HUW46_07725	COG0745	RESPONSE REGULATOR receiver
HUW46_07741	COG0488	(ABC) transporter
HUW46_07747	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUW46_07750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUW46_07754	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW46_07757	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW46_07758	COG1263	PTS System
HUW46_07759	COG2188	Transcriptional regulator
HUW46_07760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW46_07768	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUW46_07769	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW46_07770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUW46_07771	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUW46_07774	COG0006	proline dipeptidase activity
HUW46_07775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUW46_07776	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW46_07779	COG0540	Belongs to the ATCase OTCase family
HUW46_07782	COG0505	Belongs to the CarA family
HUW46_07784	COG0284	orotidine-5'-phosphate decarboxylase activity
HUW46_07786	COG0194	GDP metabolic process
HUW46_07787	COG1758	RNA polymerase activity
HUW46_07789	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW46_07796	COG0405	Gamma-glutamyltransferase
HUW46_07797	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW46_07802	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW46_07802	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW46_07803	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUW46_07805	COG2318	DinB family
HUW46_07806	COG1309	transcriptional regulator
HUW46_07810	COG0322	excinuclease ABC activity
HUW46_07811	COG1660	Displays ATPase and GTPase activities
HUW46_07813	COG1481	regulation of sporulation
HUW46_07815	COG0463	Glycosyl transferase, family 2
HUW46_07825	COG0297	glycogen (starch) synthase activity
HUW46_07837	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUW46_07838	COG0126	phosphoglycerate kinase activity
HUW46_07839	COG0149	triose-phosphate isomerase activity
HUW46_07842	COG3850	Histidine kinase
HUW46_07845	COG0363	glucosamine-6-phosphate deaminase activity
HUW46_07848	COG0166	Belongs to the GPI family
HUW46_07848	COG0166	Belongs to the GPI family
HUW46_07849	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW46_07851	COG0109	protoheme IX farnesyltransferase activity
HUW46_07859	COG0583	DNA-binding transcription factor activity
HUW46_07862	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_07863	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_07863	COG2022	thiamine diphosphate biosynthetic process
HUW46_07865	COG1612	heme a metabolic process
HUW46_07872	COG0396	ATPase activity
HUW46_07875	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW46_07876	COG0681	Belongs to the peptidase S26 family
HUW46_07877	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUW46_07879	COG4585	Histidine kinase
HUW46_07880	COG2197	response regulator
HUW46_07881	COG2200	EAL domain
HUW46_07881	COG2202	Pas domain
HUW46_07881	COG2199	diguanylate cyclase activity
HUW46_07887	COG0488	(ABC) transporter
HUW46_07890	COG1132	(ABC) transporter
HUW46_07892	COG2267	carboxylic ester hydrolase activity
HUW46_07893	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUW46_07894	COG1316	TRANSCRIPTIONal
HUW46_07896	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW46_07903	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW46_07904	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW46_07904	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUW46_07906	COG1024	Enoyl-CoA hydratase
HUW46_07910	COG1960	acyl-CoA dehydrogenase activity
HUW46_07911	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW46_07915	COG1309	transcriptional regulator
HUW46_07917	COG3469	chitinase activity
HUW46_07932	COG1595	DNA-templated transcription, initiation
HUW46_07938	COG0406	alpha-ribazole phosphatase activity
HUW46_07941	COG0475	glutathione-regulated potassium exporter activity
HUW46_07942	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW46_07943	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_07944	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_07947	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW46_07948	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW46_07957	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_07959	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW46_07960	COG1819	glycosyl
HUW46_07961	COG3903	Transcriptional regulator
HUW46_07961	COG3629	intracellular signal transduction
HUW46_07965	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_07974	COG3629	intracellular signal transduction
HUW46_07974	COG3903	Transcriptional regulator
HUW46_07985	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_07988	COG2124	cytochrome p450
HUW46_07994	COG0477	Major facilitator Superfamily
HUW46_07996	COG0402	S-adenosylhomocysteine deaminase activity
HUW46_07997	COG0166	Belongs to the GPI family
HUW46_07998	COG0488	(ABC) transporter
HUW46_07999	COG0488	(ABC) transporter
HUW46_08001	COG0583	DNA-binding transcription factor activity
HUW46_08005	COG0537	adenosine 5'-monophosphoramidase activity
HUW46_08006	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08008	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_08009	COG1309	transcriptional regulator
HUW46_08011	COG2378	regulation of single-species biofilm formation
HUW46_08012	COG1960	acyl-CoA dehydrogenase activity
HUW46_08013	COG1960	acyl-CoA dehydrogenase activity
HUW46_08014	COG1960	acyl-CoA dehydrogenase activity
HUW46_08021	COG1940	carbohydrate kinase activity
HUW46_08022	COG0531	amino acid
HUW46_08023	COG3250	beta-galactosidase activity
HUW46_08025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUW46_08038	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_08045	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08045	COG3321	synthase
HUW46_08045	COG0604	alcohol dehydrogenase
HUW46_08046	COG2197	response regulator
HUW46_08051	COG3842	ATPase activity
HUW46_08053	COG3458	cephalosporin-C deacetylase activity
HUW46_08066	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUW46_08069	COG1408	metallophosphoesterase
HUW46_08071	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUW46_08071	COG0456	acetyltransferase
HUW46_08081	COG5650	phosphatidylinositol metabolic process
HUW46_08083	COG0596	Alpha beta hydrolase
HUW46_08084	COG0328	RNA-DNA hybrid ribonuclease activity
HUW46_08086	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_08087	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_08093	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW46_08095	COG4585	Histidine kinase
HUW46_08097	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW46_08099	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW46_08105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUW46_08106	COG0517	IMP dehydrogenase activity
HUW46_08106	COG4175	Glycine betaine
HUW46_08107	COG4176	ABC-type proline glycine betaine transport system permease component
HUW46_08108	COG2113	Glycine betaine
HUW46_08112	COG0583	DNA-binding transcription factor activity
HUW46_08116	COG0477	Major facilitator Superfamily
HUW46_08117	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_08131	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_08132	COG0789	Transcriptional regulator
HUW46_08134	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08137	COG2124	cytochrome p450
HUW46_08163	COG4585	Histidine kinase
HUW46_08164	COG2197	response regulator
HUW46_08166	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HUW46_08168	COG4941	Belongs to the sigma-70 factor family
HUW46_08169	COG3795	YCII-related domain
HUW46_08175	COG0542	response to heat
HUW46_08182	COG2409	Drug exporters of the RND superfamily
HUW46_08185	COG4989	oxidoreductase activity
HUW46_08186	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_08190	COG1733	regulation of RNA biosynthetic process
HUW46_08191	COG0583	DNA-binding transcription factor activity
HUW46_08192	COG0473	3-isopropylmalate dehydrogenase activity
HUW46_08193	COG0596	Alpha beta hydrolase
HUW46_08196	COG1573	uracil-dna glycosylase
HUW46_08198	COG1846	Transcriptional regulator
HUW46_08199	COG1609	Transcriptional regulator
HUW46_08200	COG4952	isomerase
HUW46_08207	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW46_08209	COG1125	glycine betaine transport
HUW46_08209	COG0517	IMP dehydrogenase activity
HUW46_08222	COG1309	transcriptional regulator
HUW46_08223	COG1799	cell septum assembly
HUW46_08224	COG0477	Major facilitator Superfamily
HUW46_08235	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_08240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_08241	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08243	COG2226	methyltransferase
HUW46_08244	COG2124	cytochrome p450
HUW46_08245	COG2226	methyltransferase
HUW46_08245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08245	COG3433	isochorismatase activity
HUW46_08246	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08252	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUW46_08256	COG2072	flavoprotein involved in K transport
HUW46_08258	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_08268	COG0477	Major facilitator Superfamily
HUW46_08269	COG1335	isochorismatase
HUW46_08272	COG1834	amidinotransferase
HUW46_08276	COG2226	methyltransferase
HUW46_08276	COG3433	isochorismatase activity
HUW46_08276	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08286	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW46_08289	COG0183	Belongs to the thiolase family
HUW46_08290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_08291	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08292	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW46_08293	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW46_08294	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_08296	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW46_08297	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW46_08304	COG1960	acyl-CoA dehydrogenase activity
HUW46_08317	COG0640	Transcriptional regulator
HUW46_08318	COG0346	lactoylglutathione lyase activity
HUW46_08320	COG0583	DNA-binding transcription factor activity
HUW46_08322	COG0747	negative chemotaxis
HUW46_08324	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_08329	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW46_08331	COG1404	Belongs to the peptidase S8 family
HUW46_08332	COG1063	alcohol dehydrogenase
HUW46_08336	COG2197	response regulator
HUW46_08339	COG0477	Major facilitator Superfamily
HUW46_08342	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HUW46_08343	COG1960	acyl-CoA dehydrogenase activity
HUW46_08345	COG1960	acyl-CoA dehydrogenase activity
HUW46_08348	COG0644	oxidoreductase
HUW46_08353	COG0477	Major facilitator Superfamily
HUW46_08355	COG0583	DNA-binding transcription factor activity
HUW46_08369	COG0477	Major facilitator Superfamily
HUW46_08373	COG1252	NADH dehydrogenase
HUW46_08375	COG0464	growth
HUW46_08379	COG0640	Transcriptional regulator
HUW46_08386	COG0243	molybdopterin cofactor binding
HUW46_08392	COG1414	Transcriptional regulator
HUW46_08393	COG4608	Belongs to the ABC transporter superfamily
HUW46_08394	COG0444	Belongs to the ABC transporter superfamily
HUW46_08398	COG0747	negative chemotaxis
HUW46_08399	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW46_08401	COG0673	inositol 2-dehydrogenase activity
HUW46_08404	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUW46_08407	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_08410	COG0640	Transcriptional regulator
HUW46_08413	COG2815	serine threonine protein kinase
HUW46_08413	COG0515	serine threonine protein kinase
HUW46_08431	COG1674	ftsk spoiiie
HUW46_08433	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_08434	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW46_08438	COG0667	Aldo Keto reductase
HUW46_08439	COG1968	undecaprenyl-diphosphatase activity
HUW46_08441	COG0339	signal peptide processing
HUW46_08443	COG1090	epimerase
HUW46_08448	COG0039	L-malate dehydrogenase activity
HUW46_08449	COG1846	Transcriptional regulator
HUW46_08454	COG3537	Alpha-1,2-mannosidase
HUW46_08457	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08460	COG3537	Alpha-1,2-mannosidase
HUW46_08461	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW46_08462	COG2362	D-Aminopeptidase
HUW46_08463	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUW46_08467	COG0747	negative chemotaxis
HUW46_08468	COG0601	transmembrane transport
HUW46_08469	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_08477	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUW46_08485	COG1595	DNA-templated transcription, initiation
HUW46_08487	COG1131	(ABC) transporter
HUW46_08490	COG0477	Major facilitator Superfamily
HUW46_08497	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_08499	COG4941	Belongs to the sigma-70 factor family
HUW46_08500	COG1309	transcriptional regulator
HUW46_08501	COG2267	carboxylic ester hydrolase activity
HUW46_08502	COG3795	YCII-related domain
HUW46_08503	COG4941	Belongs to the sigma-70 factor family
HUW46_08505	COG0667	Aldo Keto reductase
HUW46_08508	COG0300	oxidoreductase activity
HUW46_08509	COG4941	Belongs to the sigma-70 factor family
HUW46_08513	COG4974	Belongs to the 'phage' integrase family
HUW46_08518	COG1309	transcriptional regulator
HUW46_08523	COG0604	alcohol dehydrogenase
HUW46_08523	COG3321	synthase
HUW46_08527	COG1902	pentaerythritol trinitrate reductase activity
HUW46_08540	COG2188	Transcriptional regulator
HUW46_08542	COG2197	response regulator
HUW46_08549	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW46_08551	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW46_08552	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_08554	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08554	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW46_08559	COG2197	response regulator
HUW46_08561	COG1509	lysine 2,3-aminomutase activity
HUW46_08563	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08565	COG1309	transcriptional regulator
HUW46_08575	COG0367	asparagine synthase
HUW46_08578	COG2124	cytochrome p450
HUW46_08578	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUW46_08586	COG3903	Transcriptional regulator
HUW46_08586	COG3629	intracellular signal transduction
HUW46_08589	COG1063	alcohol dehydrogenase
HUW46_08592	COG3284	Transcriptional regulator
HUW46_08594	COG1280	lysine exporter protein (LysE YggA)
HUW46_08604	COG3903	Transcriptional regulator
HUW46_08604	COG3629	intracellular signal transduction
HUW46_08608	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_08609	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_08611	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUW46_08611	COG2070	2-Nitropropane dioxygenase
HUW46_08612	COG0300	oxidoreductase activity
HUW46_08612	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08612	COG3321	synthase
HUW46_08612	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08612	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_08613	COG3321	synthase
HUW46_08613	COG0604	alcohol dehydrogenase
HUW46_08613	COG3321	synthase
HUW46_08613	COG0604	alcohol dehydrogenase
HUW46_08615	COG4221	oxidoreductase activity
HUW46_08615	COG0300	oxidoreductase activity
HUW46_08615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW46_08615	COG3321	synthase
HUW46_08618	COG2175	clavaminate synthase activity
HUW46_08629	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUW46_08634	COG0492	ferredoxin-NADP+ reductase activity
HUW46_08647	COG2409	Drug exporters of the RND superfamily
HUW46_08649	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_08654	COG0006	proline dipeptidase activity
HUW46_08660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_08661	COG1309	transcriptional regulator
HUW46_08668	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW46_08673	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_08677	COG0477	Major facilitator Superfamily
HUW46_08685	COG0640	Transcriptional regulator
HUW46_08687	COG2197	response regulator
HUW46_08692	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW46_08693	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW46_08696	COG2814	Major facilitator Superfamily
HUW46_08699	COG0587	DNA-directed DNA polymerase activity
HUW46_08701	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUW46_08704	COG0604	alcohol dehydrogenase
HUW46_08706	COG1960	acyl-CoA dehydrogenase activity
HUW46_08710	COG0583	DNA-binding transcription factor activity
HUW46_08713	COG1960	acyl-CoA dehydrogenase activity
HUW46_08714	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08715	COG2030	dehydratase
HUW46_08717	COG0183	Belongs to the thiolase family
HUW46_08719	COG4221	oxidoreductase activity
HUW46_08720	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08723	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUW46_08727	COG1124	(ABC) transporter
HUW46_08728	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_08729	COG0601	transmembrane transport
HUW46_08732	COG1414	Transcriptional regulator
HUW46_08733	COG0247	lactate metabolic process
HUW46_08733	COG0277	FAD linked oxidase domain protein
HUW46_08734	COG1454	alcohol dehydrogenase
HUW46_08735	COG0477	Major facilitator Superfamily
HUW46_08736	COG0280	phosphate acetyltransferase
HUW46_08737	COG1414	Transcriptional regulator
HUW46_08738	COG1414	Transcriptional regulator
HUW46_08739	COG2271	Major facilitator Superfamily
HUW46_08740	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_08741	COG0045	succinate-CoA ligase (ADP-forming) activity
HUW46_08742	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUW46_08743	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_08746	COG4251	negative regulation of phosphorylation
HUW46_08747	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HUW46_08748	COG5002	protein histidine kinase activity
HUW46_08764	COG1414	Transcriptional regulator
HUW46_08767	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUW46_08768	COG2855	membrane
HUW46_08770	COG1113	amino acid transport
HUW46_08775	COG2018	Roadblock/LC7 domain
HUW46_08788	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUW46_08789	COG5001	Diguanylate cyclase
HUW46_08791	COG2124	cytochrome p450
HUW46_08798	COG1435	thymidine kinase activity
HUW46_08800	COG0463	Glycosyl transferase, family 2
HUW46_08802	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUW46_08803	COG1509	lysine 2,3-aminomutase activity
HUW46_08805	COG3220	belongs to the UPF0276 family
HUW46_08811	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_08820	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08824	COG1309	transcriptional regulator
HUW46_08825	COG0657	acetylesterase activity
HUW46_08828	COG0747	negative chemotaxis
HUW46_08829	COG0601	transmembrane transport
HUW46_08832	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08836	COG2814	Major facilitator Superfamily
HUW46_08841	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08847	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_08848	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW46_08849	COG1802	Transcriptional regulator
HUW46_08850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW46_08856	COG1657	PFAM Prenyltransferase squalene oxidase
HUW46_08858	COG0596	Alpha beta hydrolase
HUW46_08863	COG0745	RESPONSE REGULATOR receiver
HUW46_08864	COG1794	racemase activity, acting on amino acids and derivatives
HUW46_08865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUW46_08866	COG1802	Transcriptional regulator
HUW46_08867	COG2223	nitrite transmembrane transporter activity
HUW46_08869	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUW46_08871	COG0583	DNA-binding transcription factor activity
HUW46_08873	COG3629	intracellular signal transduction
HUW46_08873	COG3903	Transcriptional regulator
HUW46_08885	COG4552	Acetyltransferase involved in intracellular survival and related
HUW46_08891	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW46_08893	COG2378	regulation of single-species biofilm formation
HUW46_08895	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUW46_08899	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUW46_08900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUW46_08907	COG1222	aaa ATPase
HUW46_08910	COG0517	IMP dehydrogenase activity
HUW46_08910	COG1994	Peptidase M50
HUW46_08913	COG1192	Involved in chromosome partitioning
HUW46_08915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUW46_08916	COG0140	phosphoribosyl-ATP diphosphatase activity
HUW46_08918	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW46_08920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW46_08921	COG0646	methionine synthase
HUW46_08921	COG1410	methionine synthase
HUW46_08923	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUW46_08924	COG0488	(ABC) transporter
HUW46_08925	COG0215	cysteine-tRNA ligase activity
HUW46_08931	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HUW46_08933	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUW46_08940	COG0477	Major facilitator Superfamily
HUW46_08945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUW46_08947	COG2304	oxidoreductase activity
HUW46_08949	COG0714	Associated with various cellular activities
HUW46_08951	COG3883	PFAM NLP P60 protein
HUW46_08951	COG0791	NLP P60 protein
HUW46_08952	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUW46_08956	COG0702	epimerase
HUW46_08959	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUW46_08960	COG0121	glutamine amidotransferase
HUW46_08961	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW46_08962	COG3572	ergothioneine biosynthetic process
HUW46_08963	COG0583	DNA-binding transcription factor activity
HUW46_08964	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUW46_08965	COG1309	transcriptional regulator
HUW46_08968	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_08981	COG1716	ATPase activity
HUW46_08982	COG0509	glycine decarboxylation via glycine cleavage system
HUW46_08987	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW46_08990	COG1648	precorrin-2 dehydrogenase activity
HUW46_08990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUW46_08994	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW46_08995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUW46_08999	COG0254	rRNA binding
HUW46_09001	COG0523	cobalamin synthesis protein
HUW46_09003	COG2211	Major facilitator Superfamily
HUW46_09006	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_09008	COG1309	transcriptional regulator
HUW46_09009	COG0789	Transcriptional regulator
HUW46_09009	COG4978	Transcriptional regulator
HUW46_09013	COG1414	Transcriptional regulator
HUW46_09015	COG4221	oxidoreductase activity
HUW46_09016	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_09018	COG1309	transcriptional regulator
HUW46_09019	COG3246	L-lysine catabolic process to acetate
HUW46_09020	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW46_09023	COG0601	transmembrane transport
HUW46_09024	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW46_09027	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW46_09028	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUW46_09029	COG1116	anion transmembrane transporter activity
HUW46_09030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUW46_09033	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUW46_09034	COG1028	Short-chain dehydrogenase reductase Sdr
HUW46_09035	COG0539	negative regulation of cytoplasmic translation
HUW46_09036	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW46_09039	COG1511	domain protein
HUW46_09043	COG0667	Aldo Keto reductase
HUW46_09044	COG1309	transcriptional regulator
HUW46_09080	COG0154	amidase activity
HUW46_09081	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW46_09091	COG3903	Transcriptional regulator
HUW46_09091	COG3629	intracellular signal transduction
HUW46_09096	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW46_09103	COG3903	Transcriptional regulator
HUW46_09103	COG3629	intracellular signal transduction
HUW46_09122	COG0542	response to heat
HUW46_09181	COG1074	ATP-dependent DNA helicase activity
HUW46_09183	COG0542	response to heat
HUW46_09208	COG0750	zinc metalloprotease
HUW46_09255	COG0629	single-stranded DNA binding
HUW46_09266	COG3483	tryptophan 2,3-dioxygenase activity
HUW46_09279	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW46_09282	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW46_09285	COG4249	Peptidase C14 caspase catalytic subunit p20
HUW46_09285	COG2319	Wd-40 repeat
HUW46_09288	COG3903	Transcriptional regulator
HUW46_09288	COG3629	intracellular signal transduction
HUW46_09290	COG0494	nUDIX hydrolase
HUW46_09294	COG1088	dTDP-glucose 4,6-dehydratase activity
HUW46_09295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW46_09296	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW46_09297	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW46_09306	COG3285	dna ligase
HUW46_09306	COG1793	dna ligase
HUW46_09317	COG0587	DNA-directed DNA polymerase activity
HUW46_09333	COG3903	Transcriptional regulator
HUW46_09333	COG3629	intracellular signal transduction
HUW46_09336	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUW46_09337	COG1129	ABC transporter
HUW46_09368	COG1234	tRNA 3'-trailer cleavage
HUW46_09412	COG0617	tRNA 3'-terminal CCA addition
HUW46_09412	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW46_09412	COG0517	IMP dehydrogenase activity
HUW46_09414	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW46_09414	COG0617	tRNA 3'-terminal CCA addition
HUW46_09414	COG0517	IMP dehydrogenase activity
HUW46_09427	COG1396	sequence-specific DNA binding
HUW46_09428	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUW46_09429	COG1113	amino acid transport
HUW46_09431	COG0109	protoheme IX farnesyltransferase activity
HUW46_09433	COG0084	hydrolase, TatD family'
HUW46_09439	COG2197	response regulator
HUW46_09443	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW46_09453	COG0436	Aminotransferase
HUW46_09455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW46_09456	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW46_09458	COG0475	glutathione-regulated potassium exporter activity
HUW46_09470	COG2072	flavoprotein involved in K transport
HUW46_09479	COG1609	Transcriptional regulator
HUW46_09481	COG2201	protein-glutamate methylesterase activity
HUW46_09482	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW46_09488	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW46_09489	COG1396	sequence-specific DNA binding
HUW46_09490	COG0740	serine-type endopeptidase activity
HUW46_09491	COG0740	serine-type endopeptidase activity
HUW46_09493	COG0318	PFAM AMP-dependent synthetase and ligase
HUW46_09494	COG1024	Enoyl-CoA hydratase
HUW46_09497	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW46_09501	COG3842	ATPase activity
HUW46_09502	COG1177	transmembrane transport
HUW46_09503	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUW46_09505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUW46_09506	COG1012	belongs to the aldehyde dehydrogenase family
HUW46_09507	COG1309	transcriptional regulator
HUW46_09526	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUW46_09528	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW46_09541	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUW46_09542	COG0288	reversible hydration of carbon dioxide
HUW46_09544	COG0028	Belongs to the TPP enzyme family
HUW46_09567	COG0454	-acetyltransferase