locus-tag	class	description
I6J71_00015	COG1408	metallophosphoesterase
I6J71_00030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J71_00080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_00130	COG0596	Alpha beta hydrolase
I6J71_00140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_00145	COG3104	oligopeptide transport
I6J71_00170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_00180	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6J71_00190	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_00205	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6J71_00210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J71_00215	COG1737	Transcriptional regulator
I6J71_00220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J71_00225	COG3876	Protein conserved in bacteria
I6J71_00230	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_00290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J71_00320	COG1754	DNA topoisomerase type I activity
I6J71_00320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J71_00325	COG2223	nitrite transmembrane transporter activity
I6J71_00340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J71_00345	COG0470	DNA polymerase III
I6J71_00385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J71_00390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J71_00395	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J71_00405	COG0037	tRNA processing
I6J71_00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_00440	COG0302	gtp cyclohydrolase
I6J71_00445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J71_00460	COG0789	Transcriptional regulator
I6J71_00485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J71_00490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J71_00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J71_00505	COG1595	DNA-templated transcription, initiation
I6J71_00515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J71_00550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6J71_00585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J71_00625	COG1609	Transcriptional regulator
I6J71_00635	COG1121	(ABC) transporter
I6J71_00640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J71_00650	COG4399	Belongs to the UPF0754 family
I6J71_00670	COG0235	Class ii aldolase
I6J71_00685	COG0215	cysteine-tRNA ligase activity
I6J71_00705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J71_00710	COG1329	Transcriptional regulator
I6J71_00715	COG2847	Copper chaperone PCu(A)C
I6J71_00720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J71_00745	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J71_00765	COG0784	Response regulator, receiver
I6J71_00765	COG2198	Histidine kinase
I6J71_00765	COG2205	protein histidine kinase activity
I6J71_00800	COG1309	transcriptional regulator
I6J71_00835	COG1946	Acyl-CoA thioesterase
I6J71_00840	COG0596	Alpha beta hydrolase
I6J71_00845	COG2124	cytochrome p450
I6J71_00880	COG3795	YCII-related domain
I6J71_00890	COG4941	Belongs to the sigma-70 factor family
I6J71_00910	COG2205	protein histidine kinase activity
I6J71_00915	COG0745	RESPONSE REGULATOR receiver
I6J71_00925	COG1832	CoA-binding protein
I6J71_00930	COG0346	lactoylglutathione lyase activity
I6J71_01005	COG0346	lactoylglutathione lyase activity
I6J71_01010	COG0400	carboxylic ester hydrolase activity
I6J71_01020	COG5416	Lipopolysaccharide assembly protein A domain
I6J71_01035	COG4399	Belongs to the UPF0754 family
I6J71_01045	COG0456	acetyltransferase
I6J71_01055	COG1917	Cupin 2, conserved barrel domain protein
I6J71_01060	COG5285	phytanoyl-CoA dioxygenase
I6J71_01065	COG3903	Transcriptional regulator
I6J71_01065	COG3629	intracellular signal transduction
I6J71_01095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J71_01100	COG2971	BadF BadG BcrA BcrD
I6J71_01105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J71_01110	COG2188	Transcriptional regulator
I6J71_01115	COG0477	Major facilitator Superfamily
I6J71_01120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_01130	COG0352	thiamine-phosphate diphosphorylase activity
I6J71_01135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_01135	COG2022	thiamine diphosphate biosynthetic process
I6J71_01145	COG2022	thiamine diphosphate biosynthetic process
I6J71_01165	COG0604	alcohol dehydrogenase
I6J71_01180	COG0351	phosphomethylpyrimidine kinase
I6J71_01185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J71_01190	COG0242	peptide deformylase activity
I6J71_01205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_01215	COG0688	phosphatidylethanolamine metabolic process
I6J71_01225	COG2261	transglycosylase associated protein
I6J71_01255	COG1278	Cold shock
I6J71_01265	COG0459	protein refolding
I6J71_01275	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_01280	COG3629	intracellular signal transduction
I6J71_01280	COG3903	Transcriptional regulator
I6J71_01295	COG1061	Type III restriction enzyme res subunit
I6J71_01370	COG1116	anion transmembrane transporter activity
I6J71_01375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_01380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_01385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_01395	COG2018	Roadblock/LC7 domain
I6J71_01410	COG2018	Roadblock/LC7 domain
I6J71_01485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J71_01490	COG3304	Inner membrane component domain
I6J71_01495	COG0384	phenazine biosynthesis protein PhzF
I6J71_01520	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_01525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_01535	COG0546	phosphoglycolate phosphatase activity
I6J71_01545	COG1278	Cold shock
I6J71_01555	COG2814	Major facilitator Superfamily
I6J71_01580	COG2252	PERMEase
I6J71_01590	COG2814	Major facilitator Superfamily
I6J71_01595	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6J71_01605	COG5398	heme oxygenase
I6J71_01620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_01645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J71_01685	COG0831	urea catabolic process
I6J71_01690	COG0832	Belongs to the urease beta subunit family
I6J71_01695	COG0804	urea catabolic process
I6J71_01705	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J71_01710	COG0829	nickel cation binding
I6J71_01720	COG0259	pyridoxamine-phosphate oxidase activity
I6J71_01745	COG1309	transcriptional regulator
I6J71_01750	COG2017	converts alpha-aldose to the beta-anomer
I6J71_01770	COG1960	acyl-CoA dehydrogenase activity
I6J71_01790	COG0415	Belongs to the DNA photolyase family
I6J71_01800	COG1668	transmembrane transport
I6J71_01805	COG4152	abc transporter atp-binding protein
I6J71_01820	COG0277	FAD linked oxidase domain protein
I6J71_01875	COG0395	ABC-type sugar transport system, permease component
I6J71_01880	COG1175	transmembrane transport
I6J71_01885	COG2182	Extracellular solute-binding protein
I6J71_01900	COG1169	isochorismate synthase
I6J71_01910	COG1960	acyl-CoA dehydrogenase activity
I6J71_01925	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_01930	COG1024	Enoyl-CoA hydratase
I6J71_01950	COG1321	iron dependent repressor
I6J71_01970	COG1984	allophanate hydrolase subunit 2
I6J71_01975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_01980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_01985	COG4336	lyase activity
I6J71_01990	COG2814	Major facilitator Superfamily
I6J71_02000	COG3469	chitinase activity
I6J71_02025	COG1940	carbohydrate kinase activity
I6J71_02025	COG1846	Transcriptional regulator
I6J71_02030	COG4166	transmembrane transport
I6J71_02040	COG0601	transmembrane transport
I6J71_02045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_02050	COG0444	Belongs to the ABC transporter superfamily
I6J71_02110	COG1846	Transcriptional regulator
I6J71_02120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J71_02120	COG2755	lipolytic protein G-D-S-L family
I6J71_02130	COG3511	phospholipase C
I6J71_02140	COG0583	DNA-binding transcription factor activity
I6J71_02145	COG0515	serine threonine protein kinase
I6J71_02150	COG1510	regulation of RNA biosynthetic process
I6J71_02155	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_02165	COG3285	dna ligase
I6J71_02165	COG1793	dna ligase
I6J71_02200	COG3629	intracellular signal transduction
I6J71_02200	COG3903	Transcriptional regulator
I6J71_02315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J71_02325	COG1131	(ABC) transporter
I6J71_02360	COG1131	(ABC) transporter
I6J71_02410	COG1131	(ABC) transporter
I6J71_02430	COG2197	response regulator
I6J71_02435	COG2860	membrane
I6J71_02450	COG1349	DNA-binding transcription factor activity
I6J71_02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_02475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_02495	COG0745	RESPONSE REGULATOR receiver
I6J71_02500	COG5002	protein histidine kinase activity
I6J71_02515	COG1131	(ABC) transporter
I6J71_02540	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J71_02540	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J71_02565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J71_02570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J71_02625	COG0629	single-stranded DNA binding
I6J71_02685	COG1793	dna ligase
I6J71_02715	COG0583	DNA-binding transcription factor activity
I6J71_02740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J71_02790	COG2258	MOSC domain
I6J71_02805	COG0596	Alpha beta hydrolase
I6J71_02815	COG0515	serine threonine protein kinase
I6J71_02825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J71_02875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J71_02880	COG0084	hydrolase, TatD family'
I6J71_02890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J71_02900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J71_02905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J71_02910	COG0488	(ABC) transporter
I6J71_02915	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_02925	COG0193	aminoacyl-tRNA hydrolase activity
I6J71_02965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J71_02990	COG0583	DNA-binding transcription factor activity
I6J71_03030	COG0586	Pfam SNARE associated Golgi protein
I6J71_03050	COG2133	pyrroloquinoline quinone binding
I6J71_03060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_03105	COG0134	indole-3-glycerol-phosphate synthase activity
I6J71_03120	COG1595	DNA-templated transcription, initiation
I6J71_03130	COG1131	(ABC) transporter
I6J71_03150	COG2837	iron assimilation
I6J71_03155	COG2822	iron ion transport
I6J71_03160	COG0672	)-iron permease
I6J71_03190	COG0148	phosphopyruvate hydratase activity
I6J71_03210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J71_03220	COG4166	transmembrane transport
I6J71_03225	COG0601	transmembrane transport
I6J71_03230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_03240	COG4608	Belongs to the ABC transporter superfamily
I6J71_03300	COG2124	cytochrome p450
I6J71_03315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_03325	COG1515	deoxyribonuclease V activity
I6J71_03335	COG1252	NADH dehydrogenase
I6J71_03340	COG2132	Multicopper oxidase
I6J71_03385	COG0135	phosphoribosylanthranilate isomerase activity
I6J71_03405	COG2368	4-hydroxyphenylacetate
I6J71_03465	COG0778	Nitroreductase
I6J71_03485	COG0583	DNA-binding transcription factor activity
I6J71_03495	COG3971	2-oxopent-4-enoate hydratase activity
I6J71_03500	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6J71_03505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_03530	COG3483	tryptophan 2,3-dioxygenase activity
I6J71_03540	COG0477	Major facilitator Superfamily
I6J71_03565	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_03595	COG1396	sequence-specific DNA binding
I6J71_03620	COG1136	(ABC) transporter
I6J71_03650	COG1316	TRANSCRIPTIONal
I6J71_03660	COG0671	phosphoesterase, PA-phosphatase related
I6J71_03755	COG0395	ABC-type sugar transport system, permease component
I6J71_03760	COG1175	transmembrane transport
I6J71_03780	COG0667	Aldo Keto reductase
I6J71_03785	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_03790	COG2197	response regulator
I6J71_03800	COG1175	transmembrane transport
I6J71_03810	COG2723	6-phospho-beta-galactosidase activity
I6J71_03820	COG3903	Transcriptional regulator
I6J71_03820	COG3629	intracellular signal transduction
I6J71_03860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J71_03895	COG0477	Major facilitator Superfamily
I6J71_03900	COG0183	Belongs to the thiolase family
I6J71_03940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_03975	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J71_03985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_03990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J71_04000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_04010	COG1331	Highly conserved protein containing a thioredoxin domain
I6J71_04060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J71_04080	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_04130	COG1793	dna ligase
I6J71_04145	COG0114	fumarate hydratase activity
I6J71_04150	COG0492	ferredoxin-NADP+ reductase activity
I6J71_04165	COG1722	exodeoxyribonuclease VII activity
I6J71_04175	COG1570	exodeoxyribonuclease VII activity
I6J71_04185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J71_04200	COG0420	3'-5' exonuclease activity
I6J71_04205	COG0419	ATPase involved in DNA repair
I6J71_04215	COG0012	GTP binding
I6J71_04280	COG1725	Transcriptional regulator
I6J71_04305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_04310	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J71_04325	COG3842	ATPase activity
I6J71_04335	COG1131	(ABC) transporter
I6J71_04345	COG0745	RESPONSE REGULATOR receiver
I6J71_04355	COG0494	nUDIX hydrolase
I6J71_04355	COG0406	alpha-ribazole phosphatase activity
I6J71_04360	COG0180	Tryptophanyl-tRNA synthetase
I6J71_04375	COG1217	gtp-binding protein TYPA
I6J71_04380	COG0747	negative chemotaxis
I6J71_04385	COG4608	Belongs to the ABC transporter superfamily
I6J71_04400	COG0601	transmembrane transport
I6J71_04405	COG4166	transmembrane transport
I6J71_04410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_04430	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_04445	COG1994	Peptidase M50
I6J71_04485	COG1482	cell wall glycoprotein biosynthetic process
I6J71_04495	COG0531	amino acid
I6J71_04540	COG0656	L-ascorbic acid biosynthetic process
I6J71_04570	COG2146	nitrite reductase [NAD(P)H] activity
I6J71_04575	COG0745	RESPONSE REGULATOR receiver
I6J71_04580	COG5002	protein histidine kinase activity
I6J71_04595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J71_04600	COG0653	protein targeting
I6J71_04620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_04655	COG1162	GTPase activity
I6J71_04660	COG2135	peptidase activity
I6J71_04675	COG1595	DNA-templated transcription, initiation
I6J71_04680	COG5662	AntiSigma factor
I6J71_04695	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_04730	COG1597	lipid kinase activity
I6J71_04745	COG0406	alpha-ribazole phosphatase activity
I6J71_04755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6J71_04760	COG0281	malic enzyme
I6J71_04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_04805	COG0567	Dehydrogenase, E1 component
I6J71_04820	COG1132	(ABC) transporter
I6J71_04825	COG0686	Belongs to the AlaDH PNT family
I6J71_04840	COG2508	Transcriptional regulator
I6J71_04840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J71_04850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_04855	COG2755	lipolytic protein G-D-S-L family
I6J71_04870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_04880	COG1960	acyl-CoA dehydrogenase activity
I6J71_04895	COG4221	oxidoreductase activity
I6J71_04970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J71_04975	COG1960	acyl-CoA dehydrogenase activity
I6J71_04980	COG1960	acyl-CoA dehydrogenase activity
I6J71_04990	COG1309	transcriptional regulator
I6J71_04995	COG0183	Belongs to the thiolase family
I6J71_05000	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_05000	COG1024	Enoyl-CoA hydratase
I6J71_05010	COG2188	Transcriptional regulator
I6J71_05025	COG4260	virion core protein, lumpy skin disease virus
I6J71_05060	COG0028	Belongs to the TPP enzyme family
I6J71_05080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J71_05090	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_05120	COG0154	amidase activity
I6J71_05165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_05170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J71_05230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_05270	COG1595	DNA-templated transcription, initiation
I6J71_05285	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_05370	COG2814	Major facilitator Superfamily
I6J71_05430	COG2188	Transcriptional regulator
I6J71_05570	COG0596	Alpha beta hydrolase
I6J71_05580	COG2755	lipolytic protein G-D-S-L family
I6J71_05590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J71_05605	COG0018	arginyl-trna synthetase
I6J71_05610	COG0019	diaminopimelate decarboxylase activity
I6J71_05615	COG0460	homoserine dehydrogenase
I6J71_05620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J71_05625	COG0083	homoserine kinase activity
I6J71_05635	COG0254	rRNA binding
I6J71_05640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J71_05660	COG0463	Glycosyl transferase, family 2
I6J71_05665	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_05685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J71_05700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J71_05705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J71_05715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J71_05720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J71_05725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J71_05730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J71_05760	COG1309	transcriptional regulator
I6J71_05765	COG1280	lysine exporter protein (LysE YggA)
I6J71_05785	COG0765	amino acid transport
I6J71_05790	COG0765	amino acid transport
I6J71_05795	COG1126	abc transporter atp-binding protein
I6J71_05810	COG1024	Enoyl-CoA hydratase
I6J71_05825	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J71_05855	COG2376	Dihydroxyacetone kinase
I6J71_05865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J71_05870	COG1522	sequence-specific DNA binding
I6J71_05875	COG0626	cystathionine gamma-synthase activity
I6J71_05900	COG2267	carboxylic ester hydrolase activity
I6J71_05910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_05915	COG0560	Phosphoserine phosphatase
I6J71_05915	COG3830	Belongs to the UPF0237 family
I6J71_05950	COG1335	isochorismatase
I6J71_05955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J71_05995	COG1794	racemase activity, acting on amino acids and derivatives
I6J71_06020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J71_06025	COG1234	tRNA 3'-trailer cleavage
I6J71_06030	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J71_06035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J71_06075	COG2188	Transcriptional regulator
I6J71_06095	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_06100	COG1295	ribonuclease BN
I6J71_06135	COG1316	TRANSCRIPTIONal
I6J71_06170	COG3844	kynureninase activity
I6J71_06185	COG2018	Roadblock/LC7 domain
I6J71_06200	COG2259	Doxx family
I6J71_06205	COG1051	belongs to the nudix hydrolase family
I6J71_06210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_06225	COG1408	metallophosphoesterase
I6J71_06245	COG1960	acyl-CoA dehydrogenase activity
I6J71_06250	COG1063	alcohol dehydrogenase
I6J71_06255	COG0022	dehydrogenase e1 component
I6J71_06275	COG1309	transcriptional regulator
I6J71_06280	COG1024	Enoyl-CoA hydratase
I6J71_06305	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_06315	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_06345	COG1733	regulation of RNA biosynthetic process
I6J71_06370	COG0662	Cupin 2, conserved barrel domain protein
I6J71_06385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_06390	COG3383	formate dehydrogenase (NAD+) activity
I6J71_06400	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_06405	COG2909	trisaccharide binding
I6J71_06415	COG4335	DNA alkylation repair
I6J71_06420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_06440	COG1309	transcriptional regulator
I6J71_06450	COG3835	regulator
I6J71_06470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_06475	COG0590	tRNA wobble adenosine to inosine editing
I6J71_06480	COG2252	PERMEase
I6J71_06490	COG1929	Belongs to the glycerate kinase type-1 family
I6J71_06500	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_06525	COG2837	iron assimilation
I6J71_06530	COG3511	phospholipase C
I6J71_06550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J71_06555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J71_06560	COG1120	ATPase activity
I6J71_06565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J71_06590	COG3250	beta-galactosidase activity
I6J71_06600	COG3250	beta-galactosidase activity
I6J71_06620	COG2226	methyltransferase
I6J71_06680	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_06695	COG0706	membrane insertase activity
I6J71_06760	COG0367	asparagine synthase
I6J71_06785	COG0789	Transcriptional regulator
I6J71_06830	COG1024	Enoyl-CoA hydratase
I6J71_06845	COG0242	peptide deformylase activity
I6J71_06880	COG3540	Alkaline phosphatase
I6J71_06910	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_06915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_06920	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_06925	COG1595	DNA-templated transcription, initiation
I6J71_06985	COG3214	Protein conserved in bacteria
I6J71_06995	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_07025	COG1126	abc transporter atp-binding protein
I6J71_07030	COG4215	(ABC) transporter
I6J71_07045	COG2186	Transcriptional regulator
I6J71_07050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_07055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_07100	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_07105	COG0583	DNA-binding transcription factor activity
I6J71_07115	COG0477	Major facilitator Superfamily
I6J71_07135	COG2072	flavoprotein involved in K transport
I6J71_07160	COG1234	tRNA 3'-trailer cleavage
I6J71_07180	COG1349	DNA-binding transcription factor activity
I6J71_07210	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_07215	COG1309	transcriptional regulator
I6J71_07220	COG0596	Alpha beta hydrolase
I6J71_07225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_07230	COG0765	amino acid transport
I6J71_07235	COG0765	amino acid transport
I6J71_07245	COG1126	abc transporter atp-binding protein
I6J71_07275	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_07280	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_07290	COG1136	(ABC) transporter
I6J71_07295	COG1136	(ABC) transporter
I6J71_07345	COG4977	sequence-specific DNA binding
I6J71_07350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_07355	COG2079	MmgE PrpD family protein
I6J71_07370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_07385	COG4214	carbohydrate transport
I6J71_07395	COG0410	ABC transporter
I6J71_07410	COG1053	succinate dehydrogenase
I6J71_07415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_07455	COG1309	transcriptional regulator
I6J71_07460	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J71_07480	COG0596	Alpha beta hydrolase
I6J71_07510	COG1414	Transcriptional regulator
I6J71_07515	COG4638	Rieske (2fe-2S)
I6J71_07530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J71_07530	COG0519	Catalyzes the synthesis of GMP from XMP
I6J71_07540	COG2814	Major facilitator Superfamily
I6J71_07575	COG0778	Nitroreductase
I6J71_07580	COG0657	acetylesterase activity
I6J71_07595	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_07640	COG1017	nitric oxide dioxygenase activity
I6J71_07640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_07650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_07655	COG1611	Belongs to the LOG family
I6J71_07665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J71_07670	COG1309	transcriptional regulator
I6J71_07690	COG1053	succinate dehydrogenase
I6J71_07715	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_07730	COG0514	ATP-dependent DNA helicase (RecQ)
I6J71_07745	COG0583	DNA-binding transcription factor activity
I6J71_07755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_07770	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_07805	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_07820	COG0753	catalase activity
I6J71_07840	COG0583	DNA-binding transcription factor activity
I6J71_07850	COG0583	DNA-binding transcription factor activity
I6J71_07865	COG2814	Major facilitator Superfamily
I6J71_07870	COG2188	Transcriptional regulator
I6J71_07885	COG1984	allophanate hydrolase subunit 2
I6J71_07890	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_07895	COG0439	Biotin carboxylase
I6J71_07905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_07910	COG2508	Transcriptional regulator
I6J71_07935	COG2226	methyltransferase
I6J71_07965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J71_07995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_08025	COG0154	amidase activity
I6J71_08030	COG0154	amidase activity
I6J71_08065	COG4413	Urea transporter
I6J71_08080	COG3540	Alkaline phosphatase
I6J71_08115	COG0531	amino acid
I6J71_08165	COG3511	phospholipase C
I6J71_08300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J71_08310	COG0477	Major facilitator Superfamily
I6J71_08315	COG1609	Transcriptional regulator
I6J71_08325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J71_08475	COG2801	Transposase and inactivated derivatives
I6J71_08535	COG2801	Transposase and inactivated derivatives
I6J71_08600	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_08605	COG2814	Major facilitator Superfamily
I6J71_08630	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_08645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J71_08650	COG4988	ABC transporter
I6J71_08660	COG1294	oxidase, subunit
I6J71_08665	COG1271	oxidase subunit
I6J71_08700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_08730	COG2267	carboxylic ester hydrolase activity
I6J71_08755	COG3483	tryptophan 2,3-dioxygenase activity
I6J71_08765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_08765	COG2226	methyltransferase
I6J71_08765	COG3433	isochorismatase activity
I6J71_08770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_08775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_08840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J71_08845	COG0433	COG0433 Predicted ATPase
I6J71_08855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_08865	COG2226	methyltransferase
I6J71_09035	COG4195	phage-related replication protein
I6J71_09090	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6J71_09105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J71_09110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_09110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_09115	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_09120	COG3469	chitinase activity
I6J71_09135	COG1476	TRANSCRIPTIONal
I6J71_09170	COG0778	Nitroreductase
I6J71_09205	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J71_09215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J71_09220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J71_09230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J71_09235	COG1492	cobalamin metabolic process
I6J71_09245	COG2197	response regulator
I6J71_09250	COG3851	Histidine kinase
I6J71_09255	COG0308	aminopeptidase N
I6J71_09265	COG1733	regulation of RNA biosynthetic process
I6J71_09280	COG0067	glutamate synthase
I6J71_09280	COG0069	glutamate synthase activity
I6J71_09280	COG0070	glutamate synthase
I6J71_09285	COG1739	Uncharacterized protein family UPF0029
I6J71_09295	COG0277	FAD linked oxidase domain protein
I6J71_09295	COG0247	lactate metabolic process
I6J71_09330	COG2072	flavoprotein involved in K transport
I6J71_09350	COG2144	transferase activity, transferring acyl groups
I6J71_09355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_09365	COG0438	transferase activity, transferring glycosyl groups
I6J71_09380	COG0235	Class ii aldolase
I6J71_09380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J71_09390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_09400	COG1595	DNA-templated transcription, initiation
I6J71_09405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_09450	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
I6J71_09545	COG1674	ftsk spoiiie
I6J71_09550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J71_09585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J71_09585	COG1796	DNA polymerase
I6J71_09605	COG3268	Saccharopine dehydrogenase
I6J71_09630	COG0475	glutathione-regulated potassium exporter activity
I6J71_09635	COG1643	Atp-dependent helicase
I6J71_09640	COG2207	Transcriptional regulator
I6J71_09645	COG0667	Aldo Keto reductase
I6J71_09680	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_09705	COG3971	2-oxopent-4-enoate hydratase activity
I6J71_09710	COG1024	Enoyl-CoA hydratase
I6J71_09715	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_09770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_09780	COG0642	Histidine kinase
I6J71_09790	COG1609	Transcriptional regulator
I6J71_09835	COG0747	negative chemotaxis
I6J71_09860	COG0366	Alpha amylase catalytic
I6J71_09880	COG1609	Transcriptional regulator
I6J71_09885	COG1414	Transcriptional regulator
I6J71_09935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J71_09945	COG4221	oxidoreductase activity
I6J71_09950	COG2267	carboxylic ester hydrolase activity
I6J71_09990	COG1937	Protein conserved in bacteria
I6J71_10005	COG1285	pathogenesis
I6J71_10010	COG0009	L-threonylcarbamoyladenylate synthase
I6J71_10020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_10030	COG0477	Major facilitator Superfamily
I6J71_10040	COG4941	Belongs to the sigma-70 factor family
I6J71_10090	COG2801	Transposase and inactivated derivatives
I6J71_10110	COG1609	Transcriptional regulator
I6J71_10115	COG0738	Major facilitator superfamily
I6J71_10120	COG0588	phosphoglycerate mutase activity
I6J71_10140	COG2902	Dehydrogenase
I6J71_10170	COG0366	Alpha amylase catalytic
I6J71_10180	COG0668	transmembrane transport
I6J71_10195	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J71_10205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J71_10220	COG0698	ribose 5-phosphate isomerase
I6J71_10270	COG0789	Transcriptional regulator
I6J71_10275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_10290	COG0531	amino acid
I6J71_10310	COG0657	acetylesterase activity
I6J71_10320	COG1024	Enoyl-CoA hydratase
I6J71_10340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_10465	COG0693	protein deglycase activity
I6J71_10490	COG0656	L-ascorbic acid biosynthetic process
I6J71_10505	COG2409	Drug exporters of the RND superfamily
I6J71_10515	COG2409	Drug exporters of the RND superfamily
I6J71_10520	COG0017	Asparaginyl-tRNA synthetase
I6J71_10550	COG1129	ABC transporter
I6J71_10555	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_10560	COG1879	ABC-type sugar transport system periplasmic component
I6J71_10565	COG0673	inositol 2-dehydrogenase activity
I6J71_10590	COG1940	carbohydrate kinase activity
I6J71_10610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J71_10620	COG4689	acetoacetate decarboxylase
I6J71_10625	COG1309	transcriptional regulator
I6J71_10630	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I6J71_10640	COG2271	Major facilitator Superfamily
I6J71_10645	COG2423	ornithine cyclodeaminase activity
I6J71_10650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J71_10660	COG3537	Alpha-1,2-mannosidase
I6J71_10710	COG2205	protein histidine kinase activity
I6J71_10720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_10725	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J71_10730	COG0740	serine-type endopeptidase activity
I6J71_10735	COG0740	serine-type endopeptidase activity
I6J71_10740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J71_10760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J71_10800	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_10820	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_10825	COG1316	TRANSCRIPTIONal
I6J71_10840	COG0477	Major facilitator Superfamily
I6J71_10855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J71_10855	COG2124	cytochrome p450
I6J71_10865	COG0525	valine-tRNA ligase activity
I6J71_10895	COG2755	lipolytic protein G-D-S-L family
I6J71_10910	COG0285	dihydrofolate synthase activity
I6J71_10920	COG0596	Alpha beta hydrolase
I6J71_10935	COG0105	UTP biosynthetic process
I6J71_10950	COG1131	(ABC) transporter
I6J71_10980	COG1530	ribonuclease E activity
I6J71_10980	COG1530	ribonuclease E activity
I6J71_10985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J71_10995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J71_11005	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_11020	COG0018	arginyl-trna synthetase
I6J71_11025	COG0477	Major facilitator Superfamily
I6J71_11035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J71_11040	COG0799	negative regulation of ribosome biogenesis
I6J71_11045	COG0406	alpha-ribazole phosphatase activity
I6J71_11050	COG2755	lipolytic protein G-D-S-L family
I6J71_11055	COG1307	EDD domain protein, DegV family
I6J71_11075	COG1555	photosystem II stabilization
I6J71_11085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J71_11095	COG0268	Binds directly to 16S ribosomal RNA
I6J71_11110	COG2226	methyltransferase
I6J71_11115	COG0481	GTPase activity
I6J71_11140	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_11145	COG2070	2-Nitropropane dioxygenase
I6J71_11150	COG0531	amino acid
I6J71_11160	COG0604	alcohol dehydrogenase
I6J71_11170	COG4290	ribonuclease
I6J71_11180	COG1024	Enoyl-CoA hydratase
I6J71_11210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J71_11225	COG1309	transcriptional regulator
I6J71_11260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_11265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_11270	COG1953	Uracil, thiamine, allantoin
I6J71_11275	COG0745	RESPONSE REGULATOR receiver
I6J71_11280	COG2205	protein histidine kinase activity
I6J71_11305	COG0667	Aldo Keto reductase
I6J71_11310	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_11360	COG0537	adenosine 5'-monophosphoramidase activity
I6J71_11370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J71_11385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J71_11410	COG1381	Involved in DNA repair and RecF pathway recombination
I6J71_11415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J71_11425	COG0701	Predicted permease
I6J71_11460	COG0423	glycine-tRNA ligase activity
I6J71_11465	COG1131	(ABC) transporter
I6J71_11475	COG4585	Histidine kinase
I6J71_11480	COG2197	response regulator
I6J71_11490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J71_11510	COG1595	DNA-templated transcription, initiation
I6J71_11525	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_11555	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_11560	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_11620	COG0248	Ppx GppA phosphatase
I6J71_11625	COG1793	dna ligase
I6J71_11625	COG3285	dna ligase
I6J71_11635	COG3655	Transcriptional regulator
I6J71_11645	COG0789	Transcriptional regulator
I6J71_11680	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6J71_11685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_11790	COG1940	carbohydrate kinase activity
I6J71_11795	COG0656	L-ascorbic acid biosynthetic process
I6J71_11800	COG2197	response regulator
I6J71_11805	COG3940	Belongs to the glycosyl hydrolase 43 family
I6J71_11835	COG1609	Transcriptional regulator
I6J71_11845	COG3250	beta-galactosidase activity
I6J71_11860	COG3408	Glycogen debranching enzyme
I6J71_11885	COG0477	Major facilitator Superfamily
I6J71_11920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_11930	COG0589	response to stress
I6J71_11955	COG0667	Aldo Keto reductase
I6J71_11995	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6J71_12000	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_12005	COG1063	alcohol dehydrogenase
I6J71_12020	COG0395	ABC-type sugar transport system, permease component
I6J71_12025	COG1940	carbohydrate kinase activity
I6J71_12050	COG0702	epimerase
I6J71_12055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J71_12060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_12065	COG1595	DNA-templated transcription, initiation
I6J71_12070	COG1959	2 iron, 2 sulfur cluster binding
I6J71_12090	COG0583	DNA-binding transcription factor activity
I6J71_12120	COG2871	sodium ion transport
I6J71_12130	COG3485	protocatechuate 3,4-dioxygenase
I6J71_12135	COG1959	2 iron, 2 sulfur cluster binding
I6J71_12160	COG0438	transferase activity, transferring glycosyl groups
I6J71_12175	COG0789	Transcriptional regulator
I6J71_12190	COG1414	Transcriptional regulator
I6J71_12205	COG2271	Major facilitator Superfamily
I6J71_12260	COG0477	Major facilitator Superfamily
I6J71_12270	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_12280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_12300	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_12305	COG3473	Maleate cis-trans isomerase
I6J71_12340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_12350	COG0628	permease
I6J71_12360	COG2909	trisaccharide binding
I6J71_12415	COG0604	alcohol dehydrogenase
I6J71_12440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_12445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_12450	COG0154	amidase activity
I6J71_12465	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J71_12565	COG3118	belongs to the thioredoxin family
I6J71_12565	COG0492	ferredoxin-NADP+ reductase activity
I6J71_12580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_12590	COG1573	uracil-dna glycosylase
I6J71_12595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_12600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_12600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J71_12620	COG0667	Aldo Keto reductase
I6J71_12625	COG0477	Major facilitator Superfamily
I6J71_12650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J71_12655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J71_12675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J71_12770	COG2801	Transposase and inactivated derivatives
I6J71_12780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J71_12815	COG0778	Nitroreductase
I6J71_12820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_12830	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_12845	COG0604	alcohol dehydrogenase
I6J71_12875	COG1309	transcriptional regulator
I6J71_12880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_12885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_12900	COG1063	alcohol dehydrogenase
I6J71_12925	COG0697	spore germination
I6J71_12975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_12990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_13015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_13055	COG0583	DNA-binding transcription factor activity
I6J71_13095	COG1316	TRANSCRIPTIONal
I6J71_13120	COG5002	protein histidine kinase activity
I6J71_13155	COG0477	Major facilitator Superfamily
I6J71_13160	COG0726	polysaccharide deacetylase
I6J71_13180	COG1733	regulation of RNA biosynthetic process
I6J71_13190	COG2197	response regulator
I6J71_13210	COG3226	Transcriptional regulator
I6J71_13230	COG0546	phosphoglycolate phosphatase activity
I6J71_13250	COG0779	Required for maturation of 30S ribosomal subunits
I6J71_13265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J71_13275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J71_13300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_13310	COG0384	phenazine biosynthesis protein PhzF
I6J71_13320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J71_13340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J71_13345	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J71_13355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J71_13385	COG3214	Protein conserved in bacteria
I6J71_13420	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_13430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_13435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J71_13450	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J71_13460	COG1674	ftsk spoiiie
I6J71_13470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J71_13475	COG2755	lipolytic protein G-D-S-L family
I6J71_13475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J71_13485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J71_13495	COG1058	Belongs to the CinA family
I6J71_13495	COG1546	Belongs to the CinA family
I6J71_13500	COG1396	sequence-specific DNA binding
I6J71_13505	COG1842	Phage shock protein A
I6J71_13520	COG0167	dihydroorotate dehydrogenase activity
I6J71_13530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_13535	COG1192	Involved in chromosome partitioning
I6J71_13545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J71_13555	COG1305	Transglutaminase-like
I6J71_13565	COG0714	Associated with various cellular activities
I6J71_13590	COG1522	sequence-specific DNA binding
I6J71_13605	COG2001	Belongs to the MraZ family
I6J71_13610	COG0275	rRNA processing
I6J71_13620	COG0768	penicillin binding
I6J71_13635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J71_13640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J71_13650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J71_13655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_13670	COG2814	Major facilitator Superfamily
I6J71_13680	COG2318	DinB family
I6J71_13690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J71_13695	COG1496	oxidoreductase activity
I6J71_13700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J71_13705	COG1799	cell septum assembly
I6J71_13715	COG3599	regulation of cell shape
I6J71_13725	COG0640	Transcriptional regulator
I6J71_13730	COG0477	Major facilitator Superfamily
I6J71_13735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J71_13740	COG0768	penicillin binding
I6J71_13745	COG0640	Transcriptional regulator
I6J71_13755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_13765	COG5564	TIM-barrel signal transduction protein
I6J71_13770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J71_13775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J71_13800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_13805	COG0248	Ppx GppA phosphatase
I6J71_13835	COG1846	Transcriptional regulator
I6J71_13835	COG1940	carbohydrate kinase activity
I6J71_13850	COG0667	Aldo Keto reductase
I6J71_13865	COG0542	response to heat
I6J71_13875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J71_13885	COG0514	ATP-dependent DNA helicase (RecQ)
I6J71_13955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J71_13965	COG2201	protein-glutamate methylesterase activity
I6J71_13970	COG4585	Histidine kinase
I6J71_13980	COG2197	response regulator
I6J71_13985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_14040	COG2814	Major facilitator Superfamily
I6J71_14050	COG1609	Transcriptional regulator
I6J71_14060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_14075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_14080	COG3285	dna ligase
I6J71_14080	COG1793	dna ligase
I6J71_14125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_14135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J71_14145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J71_14155	COG3485	protocatechuate 3,4-dioxygenase
I6J71_14165	COG2197	response regulator
I6J71_14185	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_14345	COG1801	Protein of unknown function DUF72
I6J71_14355	COG1511	domain protein
I6J71_14370	COG2226	methyltransferase
I6J71_14375	COG0539	negative regulation of cytoplasmic translation
I6J71_14400	COG0237	dephospho-CoA kinase activity
I6J71_14400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J71_14405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J71_14415	COG2197	response regulator
I6J71_14430	COG1131	(ABC) transporter
I6J71_14460	COG1024	Enoyl-CoA hydratase
I6J71_14470	COG1131	(ABC) transporter
I6J71_14480	COG4946	Tricorn protease homolog
I6J71_14480	COG1506	peptidase
I6J71_14480	COG0823	Involved in the tonB-independent uptake of proteins
I6J71_14505	COG1609	Transcriptional regulator
I6J71_14510	COG1070	Carbohydrate kinase
I6J71_14535	COG0406	alpha-ribazole phosphatase activity
I6J71_14550	COG3012	SEC-C Motif Domain Protein
I6J71_14555	COG0328	RNA-DNA hybrid ribonuclease activity
I6J71_14570	COG1024	Enoyl-CoA hydratase
I6J71_14575	COG2368	4-hydroxyphenylacetate
I6J71_14595	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_14620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_14665	COG1301	dicarboxylic acid transport
I6J71_14670	COG3290	protein histidine kinase activity
I6J71_14675	COG4565	transcriptional regulatory protein
I6J71_14700	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6J71_14715	COG1414	Transcriptional regulator
I6J71_14720	COG0251	oxidation-reduction process
I6J71_14725	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J71_14745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J71_14750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J71_14755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_14760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J71_14765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J71_14765	COG0072	phenylalanine-tRNA ligase activity
I6J71_14780	COG2267	carboxylic ester hydrolase activity
I6J71_14800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J71_14805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J71_14810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J71_14815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_14820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J71_14825	COG1438	arginine binding
I6J71_14830	COG0137	argininosuccinate synthase activity
I6J71_14835	COG0165	Argininosuccinate lyase
I6J71_14840	COG2094	Belongs to the DNA glycosylase MPG family
I6J71_14845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J71_14875	COG0647	UMP catabolic process
I6J71_14890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J71_14990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J71_14995	COG0504	CTP synthase activity
I6J71_15000	COG0494	nUDIX hydrolase
I6J71_15020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J71_15035	COG2936	dipeptidyl-peptidase activity
I6J71_15040	COG0475	glutathione-regulated potassium exporter activity
I6J71_15060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J71_15070	COG1160	GTP binding
I6J71_15085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J71_15105	COG4977	sequence-specific DNA binding
I6J71_15110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J71_15115	COG1414	Transcriptional regulator
I6J71_15120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_15125	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_15140	COG5492	domain, Protein
I6J71_15160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J71_15165	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J71_15175	COG0714	Associated with various cellular activities
I6J71_15190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J71_15235	COG0590	tRNA wobble adenosine to inosine editing
I6J71_15240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_15280	COG0778	Nitroreductase
I6J71_15295	COG1674	ftsk spoiiie
I6J71_15505	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_15515	COG0477	Major facilitator Superfamily
I6J71_15545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_15565	COG0778	Nitroreductase
I6J71_15675	COG1802	Transcriptional regulator
I6J71_15690	COG1960	acyl-CoA dehydrogenase activity
I6J71_15705	COG1960	acyl-CoA dehydrogenase activity
I6J71_15750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6J71_15755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6J71_15760	COG0366	Alpha amylase catalytic
I6J71_15765	COG0366	Alpha amylase catalytic
I6J71_15775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J71_15810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_15815	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_15820	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_15875	COG1063	alcohol dehydrogenase
I6J71_15885	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_15910	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_15915	COG1609	Transcriptional regulator
I6J71_15925	COG1175	transmembrane transport
I6J71_15930	COG0395	ABC-type sugar transport system, permease component
I6J71_15935	COG0129	dihydroxy-acid dehydratase activity
I6J71_15945	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_15975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J71_15980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J71_16025	COG2197	response regulator
I6J71_16045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_16045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_16060	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_16065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_16075	COG0154	amidase activity
I6J71_16085	COG1595	DNA-templated transcription, initiation
I6J71_16090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J71_16155	COG2267	carboxylic ester hydrolase activity
I6J71_16165	COG0577	efflux transmembrane transporter activity
I6J71_16165	COG1136	(ABC) transporter
I6J71_16170	COG0745	RESPONSE REGULATOR receiver
I6J71_16175	COG2205	protein histidine kinase activity
I6J71_16190	COG1940	carbohydrate kinase activity
I6J71_16195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_16210	COG0477	Major facilitator Superfamily
I6J71_16255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_16260	COG1595	DNA-templated transcription, initiation
I6J71_16320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J71_16325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J71_16345	COG1560	Kdo2-lipid A biosynthetic process
I6J71_16350	COG0438	transferase activity, transferring glycosyl groups
I6J71_16360	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J71_16360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J71_16385	COG1396	sequence-specific DNA binding
I6J71_16390	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J71_16395	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J71_16400	COG0217	transcriptional regulatory protein
I6J71_16425	COG2255	four-way junction helicase activity
I6J71_16430	COG1862	Preprotein translocase
I6J71_16440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J71_16445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J71_16450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J71_16475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_16550	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J71_16560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J71_16605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_16610	COG1609	Transcriptional regulator
I6J71_16650	COG2318	DinB family
I6J71_16700	COG1309	transcriptional regulator
I6J71_16705	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_16720	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_16720	COG2030	dehydratase
I6J71_16725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_16730	COG2301	Belongs to the HpcH HpaI aldolase family
I6J71_16740	COG4770	biotin carboxylase activity
I6J71_16745	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_16760	COG3485	protocatechuate 3,4-dioxygenase
I6J71_16770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_16775	COG1414	Transcriptional regulator
I6J71_16780	COG0402	S-adenosylhomocysteine deaminase activity
I6J71_16785	COG1793	dna ligase
I6J71_16785	COG3285	dna ligase
I6J71_16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_16810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J71_16910	COG0542	response to heat
I6J71_16940	COG0459	protein refolding
I6J71_16970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_17015	COG2172	sigma factor antagonist activity
I6J71_17075	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_17085	COG0640	Transcriptional regulator
I6J71_17090	COG3250	beta-galactosidase activity
I6J71_17095	COG1733	regulation of RNA biosynthetic process
I6J71_17110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J71_17115	COG2814	Major facilitator Superfamily
I6J71_17140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_17145	COG2358	TRAP transporter, solute receptor (TAXI family
I6J71_17160	COG1802	Transcriptional regulator
I6J71_17165	COG1802	Transcriptional regulator
I6J71_17170	COG0583	DNA-binding transcription factor activity
I6J71_17175	COG0163	prenyltransferase activity
I6J71_17210	COG2233	PERMEase
I6J71_17225	COG1414	Transcriptional regulator
I6J71_17240	COG2814	Major facilitator Superfamily
I6J71_17250	COG0456	acetyltransferase
I6J71_17260	COG0477	Major facilitator Superfamily
I6J71_17265	COG4638	Rieske (2fe-2S)
I6J71_17270	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J71_17335	COG2814	Major facilitator Superfamily
I6J71_17345	COG1609	Transcriptional regulator
I6J71_17350	COG1129	ABC transporter
I6J71_17355	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_17360	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_17380	COG3347	Dehydrogenase
I6J71_17380	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_17390	COG1070	Carbohydrate kinase
I6J71_17395	COG0247	lactate metabolic process
I6J71_17400	COG1139	Iron-sulfur cluster binding protein
I6J71_17405	COG1556	Lactate utilization protein
I6J71_17435	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_17465	COG1396	sequence-specific DNA binding
I6J71_17480	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_17490	COG1129	ABC transporter
I6J71_17520	COG1063	alcohol dehydrogenase
I6J71_17525	COG2084	Dehydrogenase
I6J71_17530	COG1672	PFAM Archaeal ATPase
I6J71_17530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_17535	COG2080	2 iron, 2 sulfur cluster binding
I6J71_17540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J71_17545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_17555	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_17610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_17610	COG0617	tRNA 3'-terminal CCA addition
I6J71_17610	COG0517	IMP dehydrogenase activity
I6J71_17645	COG0517	IMP dehydrogenase activity
I6J71_17645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_17645	COG0617	tRNA 3'-terminal CCA addition
I6J71_17675	COG3284	Transcriptional regulator
I6J71_17705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J71_17710	COG2814	Major facilitator Superfamily
I6J71_17715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_17770	COG0138	bifunctional purine biosynthesis protein purh
I6J71_17775	COG2080	2 iron, 2 sulfur cluster binding
I6J71_17780	COG2010	Cytochrome c
I6J71_17780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_17795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_17800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_17820	COG2030	dehydratase
I6J71_17820	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_17825	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_17830	COG4670	ketone body catabolic process
I6J71_17835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_17850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J71_17870	COG3485	protocatechuate 3,4-dioxygenase
I6J71_17875	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_17880	COG0583	DNA-binding transcription factor activity
I6J71_17905	COG2188	Transcriptional regulator
I6J71_17910	COG1414	Transcriptional regulator
I6J71_17915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_17920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_17970	COG0235	Class ii aldolase
I6J71_17980	COG0683	leucine binding
I6J71_18075	COG1595	DNA-templated transcription, initiation
I6J71_18080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J71_18085	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_18115	COG2261	transglycosylase associated protein
I6J71_18155	COG1454	alcohol dehydrogenase
I6J71_18160	COG0824	Thioesterase
I6J71_18160	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_18185	COG1129	ABC transporter
I6J71_18190	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_18195	COG3284	Transcriptional regulator
I6J71_18225	COG0704	Plays a role in the regulation of phosphate uptake
I6J71_18230	COG0671	phosphoesterase, PA-phosphatase related
I6J71_18265	COG0583	DNA-binding transcription factor activity
I6J71_18295	COG1999	signal sequence binding
I6J71_18325	COG4941	Belongs to the sigma-70 factor family
I6J71_18340	COG0387	Pfam Sodium calcium exchanger
I6J71_18365	COG0028	Belongs to the TPP enzyme family
I6J71_18440	COG0651	ATP synthesis coupled electron transport
I6J71_18475	COG0709	Synthesizes selenophosphate from selenide and ATP
I6J71_18490	COG3276	selenocysteine insertion sequence binding
I6J71_18495	COG3383	formate dehydrogenase (NAD+) activity
I6J71_18495	COG0243	molybdopterin cofactor binding
I6J71_18500	COG0243	molybdopterin cofactor binding
I6J71_18500	COG3383	formate dehydrogenase (NAD+) activity
I6J71_18505	COG0437	4 iron, 4 sulfur cluster binding
I6J71_18535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_18600	COG2267	carboxylic ester hydrolase activity
I6J71_18620	COG2080	2 iron, 2 sulfur cluster binding
I6J71_18650	COG1993	acr, cog1993
I6J71_18655	COG1993	acr, cog1993
I6J71_18660	COG0515	serine threonine protein kinase
I6J71_18665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J71_18665	COG0515	serine threonine protein kinase
I6J71_18745	COG0488	(ABC) transporter
I6J71_18775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_18810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_18815	COG2211	Major facilitator Superfamily
I6J71_18830	COG0412	Dienelactone hydrolase
I6J71_18835	COG2814	Major facilitator Superfamily
I6J71_18845	COG0523	cobalamin synthesis protein
I6J71_18855	COG0254	rRNA binding
I6J71_18865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J71_18870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J71_18875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J71_18880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J71_18885	COG1648	precorrin-2 dehydrogenase activity
I6J71_18885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J71_18890	COG2267	carboxylic ester hydrolase activity
I6J71_18895	COG1024	Enoyl-CoA hydratase
I6J71_18900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_18925	COG1716	ATPase activity
I6J71_18960	COG0656	L-ascorbic acid biosynthetic process
I6J71_18975	COG1253	flavin adenine dinucleotide binding
I6J71_19020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J71_19025	COG0583	DNA-binding transcription factor activity
I6J71_19030	COG3572	ergothioneine biosynthetic process
I6J71_19035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_19040	COG0121	glutamine amidotransferase
I6J71_19045	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6J71_19070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J71_19075	COG0791	NLP P60 protein
I6J71_19075	COG3883	PFAM NLP P60 protein
I6J71_19095	COG0714	Associated with various cellular activities
I6J71_19105	COG2304	oxidoreductase activity
I6J71_19110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J71_19125	COG2205	protein histidine kinase activity
I6J71_19130	COG0745	RESPONSE REGULATOR receiver
I6J71_19135	COG0477	Major facilitator Superfamily
I6J71_19145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J71_19155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_19160	COG1024	Enoyl-CoA hydratase
I6J71_19170	COG1982	Orn Lys Arg decarboxylase major
I6J71_19175	COG0243	molybdopterin cofactor binding
I6J71_19260	COG0723	plastoquinol--plastocyanin reductase activity
I6J71_19265	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_19280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_19290	COG0300	oxidoreductase activity
I6J71_19360	COG0596	Alpha beta hydrolase
I6J71_19370	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I6J71_19410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J71_19425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J71_19435	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_19440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J71_19440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J71_19445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J71_19450	COG2192	nodulation
I6J71_19475	COG0438	transferase activity, transferring glycosyl groups
I6J71_19525	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_19550	COG0248	Ppx GppA phosphatase
I6J71_19560	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_19570	COG0277	FAD linked oxidase domain protein
I6J71_19570	COG0247	lactate metabolic process
I6J71_19575	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_19580	COG0028	Belongs to the TPP enzyme family
I6J71_19590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_19595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_19625	COG2814	Major facilitator Superfamily
I6J71_19635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J71_19645	COG0477	Major facilitator Superfamily
I6J71_19655	COG2159	amidohydrolase
I6J71_19665	COG1609	Transcriptional regulator
I6J71_19675	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_19680	COG0366	Alpha amylase catalytic
I6J71_19725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J71_19740	COG1595	DNA-templated transcription, initiation
I6J71_19775	COG0681	Belongs to the peptidase S26 family
I6J71_19785	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6J71_19795	COG1024	Enoyl-CoA hydratase
I6J71_19800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_19815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_19815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_19820	COG1620	l-lactate permease
I6J71_19830	COG2186	Transcriptional regulator
I6J71_19840	COG3842	ATPase activity
I6J71_19845	COG1175	transmembrane transport
I6J71_19855	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6J71_19880	COG2153	protein acetylation
I6J71_19920	COG3226	Transcriptional regulator
I6J71_19925	COG4638	Rieske (2fe-2S)
I6J71_19970	COG4221	oxidoreductase activity
I6J71_19985	COG0395	ABC-type sugar transport system, permease component
I6J71_19990	COG1175	transmembrane transport
I6J71_19995	COG2182	Extracellular solute-binding protein
I6J71_20000	COG4991	sh3 domain protein
I6J71_20035	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_20055	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_20090	COG2267	carboxylic ester hydrolase activity
I6J71_20125	COG0583	DNA-binding transcription factor activity
I6J71_20130	COG0028	Belongs to the TPP enzyme family
I6J71_20145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J71_20150	COG1053	succinate dehydrogenase
I6J71_20165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_20170	COG2223	nitrite transmembrane transporter activity
I6J71_20175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J71_20185	COG0583	DNA-binding transcription factor activity
I6J71_20230	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J71_20240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_20260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J71_20265	COG3383	formate dehydrogenase (NAD+) activity
I6J71_20285	COG3622	Belongs to the hyi family
I6J71_20290	COG2084	Dehydrogenase
I6J71_20295	COG3960	tartronate-semialdehyde synthase activity
I6J71_20315	COG1846	Transcriptional regulator
I6J71_20330	COG0730	response to heat
I6J71_20360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_20385	COG1793	dna ligase
I6J71_20385	COG3285	dna ligase
I6J71_20395	COG0183	Belongs to the thiolase family
I6J71_20425	COG0583	DNA-binding transcription factor activity
I6J71_20430	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6J71_20455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_20465	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_20475	COG1309	transcriptional regulator
I6J71_20485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_20495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J71_20525	COG0667	Aldo Keto reductase
I6J71_20530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_20535	COG1968	undecaprenyl-diphosphatase activity
I6J71_20545	COG0339	signal peptide processing
I6J71_20555	COG0039	L-malate dehydrogenase activity
I6J71_20585	COG3537	Alpha-1,2-mannosidase
I6J71_20595	COG0154	amidase activity
I6J71_20600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J71_20605	COG2362	D-Aminopeptidase
I6J71_20615	COG0601	transmembrane transport
I6J71_20620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_20650	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J71_20690	COG0477	Major facilitator Superfamily
I6J71_20700	COG0346	lactoylglutathione lyase activity
I6J71_20705	COG0640	Transcriptional regulator
I6J71_20715	COG1309	transcriptional regulator
I6J71_20735	COG1357	PFAM Pentapeptide repeats (8 copies)
I6J71_20740	COG4974	Belongs to the 'phage' integrase family
I6J71_20765	COG0740	serine-type endopeptidase activity
I6J71_20805	COG0596	Alpha beta hydrolase
I6J71_20810	COG4941	Belongs to the sigma-70 factor family
I6J71_20825	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_20835	COG2226	methyltransferase
I6J71_20840	COG1960	acyl-CoA dehydrogenase activity
I6J71_20845	COG1309	transcriptional regulator
I6J71_20855	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_20860	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_20865	COG4941	Belongs to the sigma-70 factor family
I6J71_20870	COG3795	YCII-related domain
I6J71_20875	COG4974	Belongs to the 'phage' integrase family
I6J71_20880	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_20905	COG1435	thymidine kinase activity
I6J71_20915	COG0463	Glycosyl transferase, family 2
I6J71_20925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_20940	COG3973	AAA domain
I6J71_20965	COG4941	Belongs to the sigma-70 factor family
I6J71_21020	COG0702	epimerase
I6J71_21030	COG4552	Acetyltransferase involved in intracellular survival and related
I6J71_21040	COG4552	Acetyltransferase involved in intracellular survival and related
I6J71_21055	COG1597	lipid kinase activity
I6J71_21065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J71_21075	COG2378	regulation of single-species biofilm formation
I6J71_21085	COG4221	oxidoreductase activity
I6J71_21095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J71_21100	COG1597	lipid kinase activity
I6J71_21110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J71_21115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J71_21155	COG1222	aaa ATPase
I6J71_21175	COG1994	Peptidase M50
I6J71_21175	COG0517	IMP dehydrogenase activity
I6J71_21190	COG1192	Involved in chromosome partitioning
I6J71_21195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J71_21200	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J71_21220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J71_21240	COG0488	(ABC) transporter
I6J71_21245	COG0215	cysteine-tRNA ligase activity
I6J71_21260	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I6J71_21280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J71_21485	COG2080	2 iron, 2 sulfur cluster binding
I6J71_21490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J71_21495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_21525	COG2770	Histidine kinase
I6J71_21525	COG2208	phosphoserine phosphatase activity
I6J71_21545	COG1073	alpha beta
I6J71_21560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_21635	COG2814	Major facilitator Superfamily
I6J71_21660	COG3158	transport of potassium into the cell
I6J71_21675	COG5285	phytanoyl-CoA dioxygenase
I6J71_21700	COG0640	Transcriptional regulator
I6J71_21750	COG1968	undecaprenyl-diphosphatase activity
I6J71_21775	COG0574	Belongs to the PEP-utilizing enzyme family
I6J71_21775	COG3848	Pyruvate phosphate dikinase
I6J71_21780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_21800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J71_21850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_21895	COG0739	heme binding
I6J71_21925	COG0778	Nitroreductase
I6J71_21935	COG4221	oxidoreductase activity
I6J71_21940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_21945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_21950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J71_21990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_21995	COG0395	ABC-type sugar transport system, permease component
I6J71_22005	COG2205	protein histidine kinase activity
I6J71_22060	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_22100	COG2197	response regulator
I6J71_22105	COG2197	response regulator
I6J71_22155	COG4221	oxidoreductase activity
I6J71_22175	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_22180	COG0477	Major facilitator Superfamily
I6J71_22185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_22205	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_22230	COG0642	Histidine kinase
I6J71_22270	COG0438	transferase activity, transferring glycosyl groups
I6J71_22275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_22285	COG0586	Pfam SNARE associated Golgi protein
I6J71_22305	COG3383	formate dehydrogenase (NAD+) activity
I6J71_22330	COG0477	Major facilitator Superfamily
I6J71_22340	COG4214	carbohydrate transport
I6J71_22345	COG1129	ABC transporter
I6J71_22355	COG2160	L-arabinose isomerase activity
I6J71_22370	COG1609	Transcriptional regulator
I6J71_22390	COG1846	Transcriptional regulator
I6J71_22415	COG1960	acyl-CoA dehydrogenase activity
I6J71_22420	COG1024	Enoyl-CoA hydratase
I6J71_22425	COG1620	l-lactate permease
I6J71_22435	COG2814	Major facilitator Superfamily
I6J71_22445	COG1802	Transcriptional regulator
I6J71_22450	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_22465	COG1301	dicarboxylic acid transport
I6J71_22515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_22515	COG0517	IMP dehydrogenase activity
I6J71_22515	COG0617	tRNA 3'-terminal CCA addition
I6J71_22520	COG2326	polyphosphate kinase activity
I6J71_22580	COG1309	transcriptional regulator
I6J71_22585	COG2124	cytochrome p450
I6J71_22585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J71_22590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_22630	COG1271	oxidase subunit
I6J71_22640	COG3387	PFAM Glycoside hydrolase 15-related
I6J71_22645	COG1252	NADH dehydrogenase
I6J71_22675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J71_22690	COG1595	DNA-templated transcription, initiation
I6J71_22705	COG0427	acetyl-CoA hydrolase
I6J71_22730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J71_22735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_22740	COG1064	alcohol dehydrogenase
I6J71_22745	COG0477	Major facilitator Superfamily
I6J71_22765	COG0477	Major facilitator Superfamily
I6J71_22770	COG4585	Histidine kinase
I6J71_22775	COG2197	response regulator
I6J71_22790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_22880	COG2771	luxR family
I6J71_22890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J71_22900	COG0535	radical SAM domain protein
I6J71_22905	COG0535	radical SAM domain protein
I6J71_22915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J71_22935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_22955	COG3629	intracellular signal transduction
I6J71_22955	COG3903	Transcriptional regulator
I6J71_23060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J71_23065	COG4208	sulfate ABC transporter
I6J71_23070	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J71_23075	COG0024	Methionine aminopeptidase
I6J71_23085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_23095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J71_23105	COG1733	regulation of RNA biosynthetic process
I6J71_23110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_23110	COG1017	nitric oxide dioxygenase activity
I6J71_23125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_23135	COG4221	oxidoreductase activity
I6J71_23140	COG0583	DNA-binding transcription factor activity
I6J71_23155	COG2080	2 iron, 2 sulfur cluster binding
I6J71_23160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J71_23165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_23235	COG1584	GPR1 FUN34 yaaH family protein
I6J71_23240	COG1620	l-lactate permease
I6J71_23245	COG0247	lactate metabolic process
I6J71_23250	COG0277	FAD linked oxidase domain protein
I6J71_23255	COG0277	FAD linked oxidase domain protein
I6J71_23310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J71_23330	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6J71_23340	COG0617	tRNA 3'-terminal CCA addition
I6J71_23340	COG0517	IMP dehydrogenase activity
I6J71_23340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_23385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_23390	COG1116	anion transmembrane transporter activity
I6J71_23415	COG2066	Belongs to the glutaminase family
I6J71_23435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_23465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_23505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_23505	COG1116	anion transmembrane transporter activity
I6J71_23510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_23515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_23525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J71_23545	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_23550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_23580	COG0154	amidase activity
I6J71_23605	COG2226	methyltransferase
I6J71_23620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J71_23625	COG2301	Belongs to the HpcH HpaI aldolase family
I6J71_23630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_23635	COG2271	Major facilitator Superfamily
I6J71_23655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_23695	COG2267	carboxylic ester hydrolase activity
I6J71_23795	COG0657	acetylesterase activity
I6J71_23830	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_23835	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6J71_23840	COG2084	Dehydrogenase
I6J71_23860	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J71_23865	COG3842	ATPase activity
I6J71_23900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_23910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_23915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J71_23920	COG2186	Transcriptional regulator
I6J71_23935	COG2159	amidohydrolase
I6J71_23940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J71_23945	COG1063	alcohol dehydrogenase
I6J71_23955	COG0698	ribose 5-phosphate isomerase
I6J71_23960	COG0588	phosphoglycerate mutase activity
I6J71_23965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_23970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J71_23990	COG1132	(ABC) transporter
I6J71_24010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_24015	COG0477	Major facilitator Superfamily
I6J71_24025	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_24045	COG0252	asparaginase activity
I6J71_24050	COG1609	Transcriptional regulator
I6J71_24065	COG1113	amino acid transport
I6J71_24070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J71_24075	COG1228	amidohydrolase
I6J71_24085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_24170	COG0601	transmembrane transport
I6J71_24175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_24180	COG4172	Belongs to the ABC transporter superfamily
I6J71_24185	COG3119	arylsulfatase activity
I6J71_24190	COG1940	carbohydrate kinase activity
I6J71_24200	COG2315	Protein conserved in bacteria
I6J71_24270	COG4447	cellulose binding
I6J71_24290	COG0583	DNA-binding transcription factor activity
I6J71_24305	COG2124	cytochrome p450
I6J71_24335	COG3293	Transposase
I6J71_24360	COG0604	alcohol dehydrogenase
I6J71_24380	COG2814	Major facilitator Superfamily
I6J71_24390	COG2188	Transcriptional regulator
I6J71_24400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_24505	COG0142	geranyltranstransferase activity
I6J71_24530	COG2226	methyltransferase
I6J71_24535	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J71_24560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J71_24570	COG2801	Transposase and inactivated derivatives
I6J71_24575	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_24680	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_24690	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_24700	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
I6J71_24715	COG3118	belongs to the thioredoxin family
I6J71_24715	COG0492	ferredoxin-NADP+ reductase activity
I6J71_24725	COG2814	Major facilitator Superfamily
I6J71_24730	COG0656	L-ascorbic acid biosynthetic process
I6J71_24745	COG2815	serine threonine protein kinase
I6J71_24745	COG0515	serine threonine protein kinase
I6J71_24785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_24820	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_24865	COG0515	serine threonine protein kinase
I6J71_24885	COG0515	serine threonine protein kinase
I6J71_24950	COG4566	intracellular signal transduction
I6J71_24965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J71_25000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_25035	COG4585	Histidine kinase
I6J71_25040	COG2197	response regulator
I6J71_25130	COG1140	nitrate reductase beta subunit
I6J71_25135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J71_25185	COG2132	Multicopper oxidase
I6J71_25195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_25215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_25275	COG0587	DNA-directed DNA polymerase activity
I6J71_25285	COG0667	Aldo Keto reductase
I6J71_25385	COG0515	serine threonine protein kinase
I6J71_25385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J71_25490	COG0121	glutamine amidotransferase
I6J71_25545	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_25575	COG2079	MmgE PrpD family protein
I6J71_25580	COG1309	transcriptional regulator
I6J71_25610	COG1309	transcriptional regulator
I6J71_25615	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_25620	COG1024	Enoyl-CoA hydratase
I6J71_25630	COG0427	acetyl-CoA hydrolase
I6J71_25635	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_25650	COG0183	Belongs to the thiolase family
I6J71_25675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_25675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_25690	COG1129	ABC transporter
I6J71_25700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_25705	COG4608	Belongs to the ABC transporter superfamily
I6J71_25710	COG0444	Belongs to the ABC transporter superfamily
I6J71_25730	COG2843	Capsule synthesis protein
I6J71_25765	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_25780	COG0535	radical SAM domain protein
I6J71_25795	COG3878	Protein conserved in bacteria
I6J71_25840	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J71_25845	COG0798	PFAM Bile acid sodium symporter
I6J71_25850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J71_25855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J71_25860	COG0640	Transcriptional regulator
I6J71_25900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J71_25915	COG1063	alcohol dehydrogenase
I6J71_25920	COG0517	IMP dehydrogenase activity
I6J71_25920	COG0516	GMP reductase activity
I6J71_25930	COG0574	Belongs to the PEP-utilizing enzyme family
I6J71_25930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J71_25935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J71_25945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J71_25950	COG1042	CoA-binding domain protein
I6J71_25950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_25950	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J71_26000	COG0438	transferase activity, transferring glycosyl groups
I6J71_26095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J71_26110	COG1993	acr, cog1993
I6J71_26195	COG0165	Argininosuccinate lyase
I6J71_26200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_26205	COG0129	dihydroxy-acid dehydratase activity
I6J71_26225	COG2197	response regulator
I6J71_26230	COG2072	flavoprotein involved in K transport
I6J71_26320	COG1733	regulation of RNA biosynthetic process
I6J71_26350	COG1309	transcriptional regulator
I6J71_26370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J71_26375	COG0142	geranyltranstransferase activity
I6J71_26385	COG0142	geranyltranstransferase activity
I6J71_26485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6J71_26490	COG1335	isochorismatase
I6J71_26495	COG2259	Doxx family
I6J71_26540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_26620	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_26755	COG2801	Transposase and inactivated derivatives
I6J71_26830	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_26885	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_26885	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J71_26895	COG3976	FMN-binding domain protein
I6J71_26895	COG1053	succinate dehydrogenase
I6J71_26900	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_26905	COG0583	DNA-binding transcription factor activity
I6J71_26910	COG0477	Major facilitator Superfamily
I6J71_26915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_26920	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_26935	COG0129	dihydroxy-acid dehydratase activity
I6J71_26975	COG4249	Peptidase C14 caspase catalytic subunit p20
I6J71_27060	COG1674	ftsk spoiiie
I6J71_27075	COG1960	acyl-CoA dehydrogenase activity
I6J71_27100	COG2124	cytochrome p450
I6J71_27110	COG1024	Enoyl-CoA hydratase
I6J71_27120	COG0439	Biotin carboxylase
I6J71_27125	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_27135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_27140	COG0562	UDP-galactopyranose mutase
I6J71_27160	COG2124	cytochrome p450
I6J71_27165	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J71_27185	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_27190	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_27205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_27230	COG1414	Transcriptional regulator
I6J71_27245	COG0410	ABC transporter
I6J71_27275	COG1946	Acyl-CoA thioesterase
I6J71_27280	COG2030	dehydratase
I6J71_27285	COG2030	dehydratase
I6J71_27300	COG1960	acyl-CoA dehydrogenase activity
I6J71_27305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J71_27315	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_27320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_27325	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_27330	COG0183	Belongs to the thiolase family
I6J71_27335	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J71_27350	COG1960	acyl-CoA dehydrogenase activity
I6J71_27400	COG2197	response regulator
I6J71_27420	COG0583	DNA-binding transcription factor activity
I6J71_27425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J71_27460	COG0367	asparagine synthase
I6J71_27470	COG2124	cytochrome p450
I6J71_27480	COG2226	methyltransferase
I6J71_27490	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_27505	COG0477	Major facilitator Superfamily
I6J71_27570	COG0477	Major facilitator Superfamily
I6J71_27645	COG1309	transcriptional regulator
I6J71_27660	COG1960	acyl-CoA dehydrogenase activity
I6J71_27680	COG1309	transcriptional regulator
I6J71_27685	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_27695	COG1309	transcriptional regulator
I6J71_27700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J71_27715	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_27720	COG1228	amidohydrolase
I6J71_27730	COG2186	Transcriptional regulator
I6J71_27740	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_27760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J71_27770	COG1595	DNA-templated transcription, initiation
I6J71_27790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_27795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J71_27825	COG0596	Alpha beta hydrolase
I6J71_27830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_27830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J71_27850	COG2301	Belongs to the HpcH HpaI aldolase family
I6J71_27855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_27860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_27865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_27890	COG1175	transmembrane transport
I6J71_27895	COG1609	Transcriptional regulator
I6J71_27900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_27920	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J71_27950	COG2367	Beta-lactamase
I6J71_27960	COG2367	Beta-lactamase
I6J71_27980	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_27990	COG1301	dicarboxylic acid transport
I6J71_28025	COG1216	Glycosyl transferase, family 2
I6J71_28035	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_28045	COG3387	PFAM Glycoside hydrolase 15-related
I6J71_28050	COG0477	Major facilitator Superfamily
I6J71_28100	COG4221	oxidoreductase activity
I6J71_28115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J71_28125	COG1609	Transcriptional regulator
I6J71_28145	COG0167	dihydroorotate dehydrogenase activity
I6J71_28150	COG2814	Major facilitator Superfamily
I6J71_28180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_28200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J71_28205	COG3938	Belongs to the proline racemase family
I6J71_28215	COG1846	Transcriptional regulator
I6J71_28220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J71_28235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J71_28265	COG1309	transcriptional regulator
I6J71_28275	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_28280	COG1960	acyl-CoA dehydrogenase activity
I6J71_28285	COG2814	Major facilitator Superfamily
I6J71_28300	COG4585	Histidine kinase
I6J71_28315	COG0459	protein refolding
I6J71_28320	COG1063	alcohol dehydrogenase
I6J71_28345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_28385	COG3511	phospholipase C
I6J71_28410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_28430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J71_28440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J71_28450	COG1126	abc transporter atp-binding protein
I6J71_28455	COG0765	amino acid transport
I6J71_28465	COG1802	Transcriptional regulator
I6J71_28500	COG0601	transmembrane transport
I6J71_28505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_28510	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_28525	COG4608	Belongs to the ABC transporter superfamily
I6J71_28535	COG1802	Transcriptional regulator
I6J71_28550	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_28550	COG1672	PFAM Archaeal ATPase
I6J71_28555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J71_28560	COG0277	FAD linked oxidase domain protein
I6J71_28565	COG2814	Major facilitator Superfamily
I6J71_28570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_28575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_28600	COG1116	anion transmembrane transporter activity
I6J71_28600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_28605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_28625	COG2197	response regulator
I6J71_28630	COG3903	Transcriptional regulator
I6J71_28630	COG3629	intracellular signal transduction
I6J71_28635	COG0739	heme binding
I6J71_28660	COG2197	response regulator
I6J71_28675	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6J71_28695	COG3237	CsbD-like
I6J71_28730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_28735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_28745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J71_28750	COG0697	spore germination
I6J71_28765	COG3835	regulator
I6J71_28790	COG1657	PFAM Prenyltransferase squalene oxidase
I6J71_28805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_28805	COG2010	Cytochrome c
I6J71_28810	COG2080	2 iron, 2 sulfur cluster binding
I6J71_28830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_28840	COG1764	response to oxidative stress
I6J71_28870	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_28880	COG1132	(ABC) transporter
I6J71_28930	COG1349	DNA-binding transcription factor activity
I6J71_28935	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_28965	COG0583	DNA-binding transcription factor activity
I6J71_28990	COG2423	ornithine cyclodeaminase activity
I6J71_29015	COG0300	oxidoreductase activity
I6J71_29025	COG4221	oxidoreductase activity
I6J71_29050	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_29075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J71_29090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J71_29095	COG0587	DNA-directed DNA polymerase activity
I6J71_29110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_29115	COG2814	Major facilitator Superfamily
I6J71_29140	COG2368	4-hydroxyphenylacetate
I6J71_29165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_29170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_29170	COG1116	anion transmembrane transporter activity
I6J71_29185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_29195	COG3618	amidohydrolase
I6J71_29200	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J71_29215	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_29225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J71_29225	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_29230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J71_29235	COG1309	transcriptional regulator
I6J71_29245	COG0477	Major facilitator Superfamily
I6J71_29255	COG4336	lyase activity
I6J71_29260	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J71_29265	COG1402	creatininase
I6J71_29270	COG2188	Transcriptional regulator
I6J71_29275	COG2814	Major facilitator Superfamily
I6J71_29285	COG0667	Aldo Keto reductase
I6J71_29300	COG4941	Belongs to the sigma-70 factor family
I6J71_29350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_29355	COG0601	transmembrane transport
I6J71_29375	COG0583	DNA-binding transcription factor activity
I6J71_29390	COG0148	phosphopyruvate hydratase activity
I6J71_29395	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6J71_29400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6J71_29405	COG3639	organic phosphonate transmembrane transporter activity
I6J71_29425	COG3626	phosphonate metabolism
I6J71_29430	COG3627	carbon phosphorus lyase activity
I6J71_29440	COG3454	Phosphonate metabolism
I6J71_29480	COG2814	Major facilitator Superfamily
I6J71_29480	COG0477	Major facilitator Superfamily
I6J71_29485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_29490	COG1846	Transcriptional regulator
I6J71_29500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_29525	COG1335	isochorismatase
I6J71_29550	COG2264	protein methyltransferase activity
I6J71_29560	COG2423	ornithine cyclodeaminase activity
I6J71_29565	COG3938	Belongs to the proline racemase family
I6J71_29575	COG0477	Major facilitator Superfamily
I6J71_29585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_29610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_29650	COG2124	cytochrome p450
I6J71_29655	COG1309	transcriptional regulator
I6J71_29695	COG0745	RESPONSE REGULATOR receiver
I6J71_29700	COG2205	protein histidine kinase activity
I6J71_29710	COG2223	nitrite transmembrane transporter activity
I6J71_29720	COG0673	inositol 2-dehydrogenase activity
I6J71_29750	COG2186	Transcriptional regulator
I6J71_29755	COG4166	transmembrane transport
I6J71_29765	COG0444	Belongs to the ABC transporter superfamily
I6J71_29775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_29795	COG2188	Transcriptional regulator
I6J71_29800	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_29820	COG0297	glycogen (starch) synthase activity
I6J71_29830	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_29875	COG2271	Major facilitator Superfamily
I6J71_29880	COG1414	Transcriptional regulator
I6J71_29885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_29890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_29895	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_29950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J71_29980	COG0784	Response regulator, receiver
I6J71_29985	COG4251	negative regulation of phosphorylation
I6J71_29990	COG0745	RESPONSE REGULATOR receiver
I6J71_30000	COG0646	methionine synthase
I6J71_30000	COG1410	methionine synthase
I6J71_30020	COG1846	Transcriptional regulator
I6J71_30035	COG2318	DinB family
I6J71_30050	COG3964	amidohydrolase
I6J71_30060	COG1024	Enoyl-CoA hydratase
I6J71_30070	COG0765	amino acid transport
I6J71_30085	COG3622	Belongs to the hyi family
I6J71_30090	COG2084	Dehydrogenase
I6J71_30100	COG0438	transferase activity, transferring glycosyl groups
I6J71_30115	COG0656	L-ascorbic acid biosynthetic process
I6J71_30160	COG0439	Biotin carboxylase
I6J71_30165	COG1454	alcohol dehydrogenase
I6J71_30205	COG0515	serine threonine protein kinase
I6J71_30205	COG2815	serine threonine protein kinase
I6J71_30215	COG1715	Restriction endonuclease
I6J71_30230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J71_30235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J71_30260	COG1793	dna ligase
I6J71_30265	COG1414	Transcriptional regulator
I6J71_30290	COG2271	Major facilitator Superfamily
I6J71_30310	COG0066	3-isopropylmalate dehydratase activity
I6J71_30315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_30320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_30325	COG0066	3-isopropylmalate dehydratase activity
I6J71_30340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_30345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_30375	COG2826	transposase and inactivated derivatives, IS30 family
I6J71_30385	COG0477	Major facilitator Superfamily
I6J71_30395	COG1309	transcriptional regulator
I6J71_30430	COG1846	Transcriptional regulator
I6J71_30440	COG0564	pseudouridine synthase activity
I6J71_30455	COG1063	alcohol dehydrogenase
I6J71_30465	COG2124	cytochrome p450
I6J71_30490	COG1609	Transcriptional regulator
I6J71_30500	COG1940	carbohydrate kinase activity
I6J71_30505	COG3250	beta-galactosidase activity
I6J71_30510	COG0531	amino acid
I6J71_30520	COG0484	heat shock protein binding
I6J71_30525	COG1280	lysine exporter protein (LysE YggA)
I6J71_30545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_30550	COG1960	acyl-CoA dehydrogenase activity
I6J71_30560	COG2197	response regulator
I6J71_30580	COG1960	acyl-CoA dehydrogenase activity
I6J71_30585	COG1960	acyl-CoA dehydrogenase activity
I6J71_30590	COG1960	acyl-CoA dehydrogenase activity
I6J71_30595	COG0596	Alpha beta hydrolase
I6J71_30600	COG0154	amidase activity
I6J71_30615	COG1309	transcriptional regulator
I6J71_30625	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_30635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_30650	COG3573	Dehydrogenase
I6J71_30655	COG0129	dihydroxy-acid dehydratase activity
I6J71_30660	COG0477	Major facilitator Superfamily
I6J71_30665	COG0583	DNA-binding transcription factor activity
I6J71_30670	COG1309	transcriptional regulator
I6J71_30685	COG3706	GGDEF domain
I6J71_30700	COG3469	chitinase activity
I6J71_30735	COG0583	DNA-binding transcription factor activity
I6J71_30750	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_30765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_30770	COG1960	acyl-CoA dehydrogenase activity
I6J71_30785	COG1024	Enoyl-CoA hydratase
I6J71_30790	COG4689	acetoacetate decarboxylase
I6J71_30795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_30795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J71_30800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_30830	COG1316	TRANSCRIPTIONal
I6J71_30835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J71_30845	COG4821	SIS domain
I6J71_30850	COG1132	(ABC) transporter
I6J71_30865	COG0488	(ABC) transporter
I6J71_30880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J71_30890	COG2200	EAL domain
I6J71_30890	COG2199	diguanylate cyclase activity
I6J71_30905	COG5640	endopeptidase activity
I6J71_30920	COG1742	UPF0060 membrane protein
I6J71_30930	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J71_30945	COG0396	ATPase activity
I6J71_31010	COG1278	Cold shock
I6J71_31030	COG0109	protoheme IX farnesyltransferase activity
I6J71_31040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J71_31045	COG0166	Belongs to the GPI family
I6J71_31060	COG0363	glucosamine-6-phosphate deaminase activity
I6J71_31065	COG4585	Histidine kinase
I6J71_31075	COG0277	FAD linked oxidase domain protein
I6J71_31095	COG0149	triose-phosphate isomerase activity
I6J71_31100	COG0126	phosphoglycerate kinase activity
I6J71_31105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J71_31115	COG1280	lysine exporter protein (LysE YggA)
I6J71_31160	COG1481	regulation of sporulation
I6J71_31170	COG1660	Displays ATPase and GTPase activities
I6J71_31175	COG0322	excinuclease ABC activity
I6J71_31195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J71_31200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_31200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_31230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J71_31235	COG1610	YqeY-like protein
I6J71_31250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J71_31255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J71_31265	COG1758	RNA polymerase activity
I6J71_31270	COG0194	GDP metabolic process
I6J71_31280	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J71_31290	COG0505	Belongs to the CarA family
I6J71_31305	COG0540	Belongs to the ATCase OTCase family
I6J71_31310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J71_31325	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_31335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J71_31340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J71_31345	COG0006	proline dipeptidase activity
I6J71_31365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J71_31370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J71_31375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J71_31380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J71_31415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J71_31415	COG1263	PTS System
I6J71_31415	COG2190	(PTS) system
I6J71_31420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J71_31425	COG2188	Transcriptional regulator
I6J71_31430	COG1263	PTS System
I6J71_31435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J71_31455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J71_31460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J71_31475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J71_31490	COG2084	Dehydrogenase
I6J71_31495	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6J71_31515	COG2124	cytochrome p450
I6J71_31535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J71_31565	COG0174	glutamine synthetase
I6J71_31595	COG2326	polyphosphate kinase activity
I6J71_31605	COG0640	Transcriptional regulator
I6J71_31610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_31630	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J71_31640	COG1595	DNA-templated transcription, initiation
I6J71_31660	COG1793	dna ligase
I6J71_31675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J71_31680	COG0506	proline dehydrogenase activity
I6J71_31685	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_31690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J71_31690	COG2508	Transcriptional regulator
I6J71_31705	COG0539	negative regulation of cytoplasmic translation
I6J71_31710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_31730	COG2815	serine threonine protein kinase
I6J71_31730	COG0515	serine threonine protein kinase
I6J71_31745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_31755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_31760	COG3253	May function as heme-dependent peroxidase
I6J71_31770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J71_31780	COG2197	response regulator
I6J71_31800	COG0183	Belongs to the thiolase family
I6J71_31805	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_31805	COG1024	Enoyl-CoA hydratase
I6J71_31820	COG2205	protein histidine kinase activity
I6J71_31825	COG0745	RESPONSE REGULATOR receiver
I6J71_31860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J71_31865	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_31895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J71_31900	COG0531	amino acid
I6J71_31905	COG0569	domain protein
I6J71_31935	COG0756	dUTP diphosphatase activity
I6J71_31955	COG0483	inositol monophosphate 1-phosphatase activity
I6J71_31960	COG1940	carbohydrate kinase activity
I6J71_32025	COG2197	response regulator
I6J71_32030	COG0531	amino acid
I6J71_32040	COG0174	glutamine synthetase
I6J71_32060	COG4214	carbohydrate transport
I6J71_32070	COG4213	ABC transporter substrate-binding protein
I6J71_32105	COG2313	pseudouridylate synthase activity
I6J71_32125	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_32130	COG1490	D-aminoacyl-tRNA deacylase activity
I6J71_32140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J71_32140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J71_32170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_32175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_32205	COG1295	ribonuclease BN
I6J71_32215	COG2124	cytochrome p450
I6J71_32260	COG0596	Alpha beta hydrolase
I6J71_32285	COG4585	Histidine kinase
I6J71_32290	COG2197	response regulator
I6J71_32305	COG1228	amidohydrolase
I6J71_32310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_32320	COG1473	amidohydrolase
I6J71_32395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_32420	COG2030	dehydratase
I6J71_32425	COG0196	riboflavin kinase activity
I6J71_32465	COG0657	acetylesterase activity
I6J71_32475	COG0302	gtp cyclohydrolase
I6J71_32490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J71_32500	COG1309	transcriptional regulator
I6J71_32505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_32515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_32525	COG1703	isobutyryl-CoA mutase activity
I6J71_32525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_32525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_32545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_32560	COG2018	Roadblock/LC7 domain
I6J71_32575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_32580	COG1309	transcriptional regulator
I6J71_32595	COG1566	PFAM secretion protein HlyD family protein
I6J71_32620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_32625	COG1960	acyl-CoA dehydrogenase activity
I6J71_32650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_32650	COG1672	PFAM Archaeal ATPase
I6J71_32670	COG1946	Acyl-CoA thioesterase
I6J71_32710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J71_32745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_32755	COG1940	carbohydrate kinase activity
I6J71_32765	COG0003	Pfam Anion-transporting ATPase
I6J71_32800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_32815	COG2255	four-way junction helicase activity
I6J71_32835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J71_32860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J71_32865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J71_32885	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6J71_32900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J71_32905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J71_32920	COG4585	Histidine kinase
I6J71_32925	COG2197	response regulator
I6J71_32935	COG2936	dipeptidyl-peptidase activity
I6J71_32945	COG0516	GMP reductase activity
I6J71_32945	COG0517	IMP dehydrogenase activity
I6J71_32970	COG1505	serine-type exopeptidase activity
I6J71_32980	COG3226	Transcriptional regulator
I6J71_32990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_32995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J71_33005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J71_33015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J71_33030	COG0525	valine-tRNA ligase activity
I6J71_33035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J71_33040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J71_33045	COG1196	nuclear chromosome segregation
I6J71_33055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J71_33075	COG1126	abc transporter atp-binding protein
I6J71_33080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_33085	COG0765	amino acid transport
I6J71_33090	COG0765	amino acid transport
I6J71_33100	COG1228	amidohydrolase
I6J71_33115	COG1053	succinate dehydrogenase
I6J71_33135	COG0800	Aldolase
I6J71_33140	COG2137	regulation of response to DNA damage stimulus
I6J71_33145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J71_33155	COG0443	Heat shock 70 kDa protein
I6J71_33160	COG2271	Major facilitator Superfamily
I6J71_33165	COG1201	RNA secondary structure unwinding
I6J71_33170	COG0242	peptide deformylase activity
I6J71_33190	COG1131	(ABC) transporter
I6J71_33255	COG0142	geranyltranstransferase activity
I6J71_33290	COG2268	Band 7 protein
I6J71_33305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J71_33315	COG0070	glutamate synthase
I6J71_33315	COG0069	glutamate synthase activity
I6J71_33315	COG0067	glutamate synthase
I6J71_33340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J71_33345	COG1473	amidohydrolase
I6J71_33360	COG0174	glutamine synthetase
I6J71_33365	COG0159	tryptophan synthase activity
I6J71_33370	COG0133	tryptophan synthase activity
I6J71_33375	COG0134	indole-3-glycerol-phosphate synthase activity
I6J71_33385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J71_33415	COG0107	imidazoleglycerol-phosphate synthase activity
I6J71_33445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J71_33450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J71_33460	COG1960	acyl-CoA dehydrogenase activity
I6J71_33465	COG3958	Transketolase
I6J71_33470	COG3959	Transketolase, thiamine diphosphate binding domain
I6J71_33480	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6J71_33485	COG1309	transcriptional regulator
I6J71_33490	COG2409	Drug exporters of the RND superfamily
I6J71_33500	COG1234	tRNA 3'-trailer cleavage
I6J71_33510	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J71_33515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J71_33520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J71_33545	COG0456	acetyltransferase
I6J71_33545	COG0454	-acetyltransferase
I6J71_33550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_33560	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_33585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J71_33590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J71_33600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J71_33620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J71_33635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J71_33640	COG2124	cytochrome p450
I6J71_33650	COG0438	transferase activity, transferring glycosyl groups
I6J71_33680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J71_33690	COG2010	Cytochrome c
I6J71_33695	COG1845	cytochrome c oxidase, subunit III
I6J71_33710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J71_33730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J71_33745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_33765	COG0667	Aldo Keto reductase
I6J71_33780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J71_33815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_33820	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_33835	COG1090	epimerase
I6J71_33845	COG0321	lipoyl(octanoyl) transferase activity
I6J71_33870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J71_33885	COG1376	ErfK ybiS ycfS ynhG family protein
I6J71_33915	COG0587	DNA-directed DNA polymerase activity
I6J71_33950	COG1104	cysteine desulfurase activity
I6J71_33955	COG1960	acyl-CoA dehydrogenase activity
I6J71_33990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J71_34000	COG1620	l-lactate permease
I6J71_34005	COG3201	nicotinamide mononucleotide transporter
I6J71_34015	COG1668	transmembrane transport
I6J71_34020	COG4152	abc transporter atp-binding protein
I6J71_34035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J71_34065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_34085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6J71_34095	COG1309	transcriptional regulator
I6J71_34120	COG2197	response regulator
I6J71_34135	COG0546	phosphoglycolate phosphatase activity
I6J71_34150	COG0442	prolyl-tRNA aminoacylation
I6J71_34170	COG3022	response to hydroperoxide
I6J71_34175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_34190	COG0513	Belongs to the DEAD box helicase family
I6J71_34225	COG2807	transmembrane transport
I6J71_34230	COG2186	Transcriptional regulator
I6J71_34255	COG0454	-acetyltransferase
I6J71_34255	COG0456	acetyltransferase
I6J71_34280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J71_34285	COG0750	zinc metalloprotease
I6J71_34290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J71_34300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J71_34310	COG2755	lipolytic protein G-D-S-L family
I6J71_34310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J71_34315	COG2814	Major facilitator Superfamily
I6J71_34320	COG0277	FAD linked oxidase domain protein
I6J71_34365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J71_34370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J71_34375	COG1695	Transcriptional regulator
I6J71_34380	COG2226	methyltransferase
I6J71_34390	COG0477	Major facilitator Superfamily
I6J71_34400	COG0233	cytoplasmic translational termination
I6J71_34405	COG0528	UMP kinase activity
I6J71_34410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J71_34415	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J71_34425	COG1191	sigma factor activity
I6J71_34445	COG0792	nuclease activity
I6J71_34455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J71_34460	COG0681	Belongs to the peptidase S26 family
I6J71_34465	COG0335	large ribosomal subunit rRNA binding
I6J71_34470	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J71_34475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J71_34485	COG0228	four-way junction DNA binding
I6J71_34505	COG1132	(ABC) transporter
I6J71_34525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J71_34540	COG2226	methyltransferase
I6J71_34555	COG2873	o-acetylhomoserine
I6J71_34560	COG1832	CoA-binding protein
I6J71_34590	COG4266	Belongs to the allantoicase family
I6J71_34595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_34620	COG2233	PERMEase
I6J71_34625	COG1309	transcriptional regulator
I6J71_34630	COG0281	malic enzyme
I6J71_34645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_34665	COG3835	regulator
I6J71_34670	COG0326	Molecular chaperone. Has ATPase activity
I6J71_34680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J71_34685	COG1414	Transcriptional regulator
I6J71_34690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_34710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J71_34715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_34730	COG1254	Belongs to the acylphosphatase family
I6J71_34750	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J71_34755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J71_34760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J71_34770	COG0367	asparagine synthase
I6J71_34790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_34795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_34805	COG0667	Aldo Keto reductase
I6J71_34810	COG0673	inositol 2-dehydrogenase activity
I6J71_34820	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_34840	COG3718	enzyme involved in inositol metabolism
I6J71_34845	COG3962	Belongs to the TPP enzyme family
I6J71_34855	COG0492	ferredoxin-NADP+ reductase activity
I6J71_34905	COG0746	molybdenum cofactor guanylyltransferase activity
I6J71_34910	COG1414	Transcriptional regulator
I6J71_34915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_34920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_34925	COG3485	protocatechuate 3,4-dioxygenase
I6J71_34930	COG3485	protocatechuate 3,4-dioxygenase
I6J71_34940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J71_34945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J71_34955	COG0395	ABC-type sugar transport system, permease component
I6J71_34960	COG1175	transmembrane transport
I6J71_34985	COG1929	Belongs to the glycerate kinase type-1 family
I6J71_35030	COG2186	Transcriptional regulator
I6J71_35035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_35040	COG1129	ABC transporter
I6J71_35045	COG1879	ABC-type sugar transport system periplasmic component
I6J71_35055	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_35060	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_35090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_35095	COG1120	ATPase activity
I6J71_35100	COG4122	O-methyltransferase activity
I6J71_35110	COG2186	Transcriptional regulator
I6J71_35125	COG1760	l-serine dehydratase
I6J71_35130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J71_35135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J71_35140	COG0509	glycine decarboxylation via glycine cleavage system
I6J71_35145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_35150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J71_35150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J71_35165	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_35170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J71_35210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_35215	COG0571	ribonuclease III activity
I6J71_35220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J71_35240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J71_35245	COG0742	ribosomal rna small subunit methyltransferase
I6J71_35250	COG3973	AAA domain
I6J71_35255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_35280	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6J71_35320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J71_35330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J71_35335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J71_35370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_35410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_35415	COG0252	asparaginase activity
I6J71_35425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J71_35435	COG1920	GTP binding
I6J71_35450	COG0776	regulation of translation
I6J71_35455	COG0066	3-isopropylmalate dehydratase activity
I6J71_35460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_35475	COG0776	regulation of translation
I6J71_35515	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_35520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_35525	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_35530	COG1404	Belongs to the peptidase S8 family
I6J71_35555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J71_35560	COG0440	acetolactate synthase activity
I6J71_35575	COG0129	dihydroxy-acid dehydratase activity
I6J71_35580	COG2259	Doxx family
I6J71_35585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J71_35605	COG0154	amidase activity
I6J71_35610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J71_35625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J71_35645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_35655	COG0482	sulfurtransferase activity
I6J71_35670	COG2197	response regulator
I6J71_35690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J71_35700	COG1307	EDD domain protein, DegV family
I6J71_35710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_35720	COG0386	Belongs to the glutathione peroxidase family
I6J71_35725	COG3250	beta-galactosidase activity
I6J71_35750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J71_35765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J71_35800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_35805	COG0531	amino acid
I6J71_35810	COG0110	maltose O-acetyltransferase activity
I6J71_35820	COG0791	NLP P60 protein
I6J71_35820	COG3883	PFAM NLP P60 protein
I6J71_35845	COG4552	Acetyltransferase involved in intracellular survival and related
I6J71_35855	COG1309	transcriptional regulator
I6J71_35870	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_35900	COG0492	ferredoxin-NADP+ reductase activity
I6J71_35945	COG2226	methyltransferase
I6J71_35950	COG1024	Enoyl-CoA hydratase
I6J71_35955	COG1119	ATPase activity
I6J71_35980	COG0058	SHG alpha-glucan phosphorylase activity
I6J71_36005	COG1846	Transcriptional regulator
I6J71_36015	COG3537	Alpha-1,2-mannosidase
I6J71_36020	COG3537	Alpha-1,2-mannosidase
I6J71_36025	COG1609	Transcriptional regulator
I6J71_36050	COG3275	phosphorelay sensor kinase activity
I6J71_36055	COG3279	Response regulator of the LytR AlgR family
I6J71_36065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_36075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_36095	COG0183	Belongs to the thiolase family
I6J71_36100	COG0346	lactoylglutathione lyase activity
I6J71_36125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_36130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_36135	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J71_36140	COG3396	Phenylacetate-CoA oxygenase
I6J71_36145	COG3460	Phenylacetate-CoA oxygenase
I6J71_36150	COG3396	Phenylacetate-CoA oxygenase
I6J71_36155	COG2030	dehydratase
I6J71_36155	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_36170	COG1309	transcriptional regulator
I6J71_36195	COG2072	flavoprotein involved in K transport
I6J71_36210	COG2183	response to ionizing radiation
I6J71_36220	COG0513	Belongs to the DEAD box helicase family
I6J71_36230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_36245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J71_36250	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_36255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J71_36285	COG3540	Alkaline phosphatase
I6J71_36295	COG3629	intracellular signal transduction
I6J71_36295	COG3903	Transcriptional regulator
I6J71_36320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J71_36330	COG1879	ABC-type sugar transport system periplasmic component
I6J71_36350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J71_36355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J71_36355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J71_36375	COG1129	ABC transporter
I6J71_36380	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_36385	COG2186	Transcriptional regulator
I6J71_36415	COG1131	(ABC) transporter
I6J71_36420	COG0596	Alpha beta hydrolase
I6J71_36440	COG1126	abc transporter atp-binding protein
I6J71_36445	COG0765	amino acid transport
I6J71_36450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_36520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J71_36590	COG1595	DNA-templated transcription, initiation
I6J71_36625	COG2801	Transposase and inactivated derivatives
I6J71_36670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_36685	COG3119	arylsulfatase activity
I6J71_36695	COG2814	Major facilitator Superfamily
I6J71_36710	COG1609	Transcriptional regulator
I6J71_36715	COG2814	Major facilitator Superfamily
I6J71_36720	COG3119	arylsulfatase activity
I6J71_36730	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_36775	COG0494	nUDIX hydrolase
I6J71_36785	COG0704	Plays a role in the regulation of phosphate uptake
I6J71_36800	COG4941	Belongs to the sigma-70 factor family
I6J71_36820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_36830	COG1063	alcohol dehydrogenase
I6J71_36865	COG3387	PFAM Glycoside hydrolase 15-related
I6J71_36870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J71_36875	COG0129	dihydroxy-acid dehydratase activity
I6J71_36880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J71_36890	COG2234	aminopeptidase activity
I6J71_36930	COG1073	alpha beta
I6J71_36935	COG1414	Transcriptional regulator
I6J71_36940	COG0477	Major facilitator Superfamily
I6J71_36945	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_36960	COG0154	amidase activity
I6J71_37010	COG2986	histidine ammonia-lyase
I6J71_37025	COG1595	DNA-templated transcription, initiation
I6J71_37030	COG2814	Major facilitator Superfamily
I6J71_37060	COG0789	Transcriptional regulator
I6J71_37065	COG2226	methyltransferase
I6J71_37085	COG0488	(ABC) transporter
I6J71_37090	COG3511	phospholipase C
I6J71_37115	COG2226	methyltransferase
I6J71_37130	COG2072	flavoprotein involved in K transport
I6J71_37135	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_37140	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_37145	COG1309	transcriptional regulator
I6J71_37165	COG2205	protein histidine kinase activity
I6J71_37175	COG0726	polysaccharide deacetylase
I6J71_37180	COG2197	response regulator
I6J71_37190	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J71_37195	COG3858	chitin binding
I6J71_37195	COG1388	LysM domain
I6J71_37235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J71_37245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_37255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_37265	COG1396	sequence-specific DNA binding
I6J71_37330	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_37335	COG0435	Glutathione S-transferase
I6J71_37345	COG2353	YceI-like domain
I6J71_37360	COG1309	transcriptional regulator
I6J71_37375	COG2814	Major facilitator Superfamily
I6J71_37395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J71_37415	COG2815	serine threonine protein kinase
I6J71_37415	COG0515	serine threonine protein kinase
I6J71_37425	COG3706	GGDEF domain
I6J71_37430	COG0393	Putative heavy-metal-binding
I6J71_37450	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_37570	COG4221	oxidoreductase activity
I6J71_37600	COG3458	cephalosporin-C deacetylase activity
I6J71_37610	COG0395	ABC-type sugar transport system, permease component
I6J71_37620	COG3345	alpha-galactosidase
I6J71_37640	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J71_37650	COG1309	transcriptional regulator
I6J71_37670	COG3795	YCII-related domain
I6J71_37675	COG4941	Belongs to the sigma-70 factor family
I6J71_37685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_37690	COG0187	DNA topoisomerase II activity
I6J71_37695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J71_37695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J71_37705	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_37720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_37725	COG1643	Atp-dependent helicase
I6J71_37730	COG1131	(ABC) transporter
I6J71_37750	COG2197	response regulator
I6J71_37755	COG4585	Histidine kinase
I6J71_37790	COG1228	amidohydrolase
I6J71_37805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J71_37810	COG2986	histidine ammonia-lyase
I6J71_37820	COG0405	Gamma-glutamyltransferase
I6J71_37830	COG0583	DNA-binding transcription factor activity
I6J71_37845	COG4585	Histidine kinase
I6J71_37850	COG2197	response regulator
I6J71_37870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J71_37875	COG2177	Part of the ABC transporter FtsEX involved in
I6J71_37880	COG2884	Cell division ATP-binding protein ftsE
I6J71_37885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J71_37920	COG1615	UPF0182 protein
I6J71_37930	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J71_38015	COG2226	methyltransferase
I6J71_38025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J71_38045	COG1522	sequence-specific DNA binding
I6J71_38065	COG0174	glutamine synthetase
I6J71_38085	COG0653	protein targeting
I6J71_38090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J71_38090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_38095	COG2169	Transcriptional regulator
I6J71_38095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J71_38105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J71_38105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J71_38110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J71_38120	COG1968	undecaprenyl-diphosphatase activity
I6J71_38125	COG0596	Alpha beta hydrolase
I6J71_38130	COG1309	transcriptional regulator
I6J71_38135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_38140	COG1177	transmembrane transport
I6J71_38145	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J71_38150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J71_38155	COG3842	ATPase activity
I6J71_38160	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_38185	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_38195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J71_38265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J71_38285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J71_38305	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J71_38315	COG3265	gluconokinase activity
I6J71_38325	COG0667	Aldo Keto reductase
I6J71_38330	COG2207	Transcriptional regulator
I6J71_38335	COG0640	Transcriptional regulator
I6J71_38350	COG1486	melibiose metabolic process
I6J71_38355	COG0395	ABC-type sugar transport system, permease component
I6J71_38360	COG1175	transmembrane transport
I6J71_38380	COG0612	Peptidase, M16
I6J71_38415	COG0714	Associated with various cellular activities
I6J71_38475	COG2378	regulation of single-species biofilm formation
I6J71_38505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J71_38505	COG2146	nitrite reductase [NAD(P)H] activity
I6J71_38510	COG2223	nitrite transmembrane transporter activity
I6J71_38515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J71_38520	COG0243	molybdopterin cofactor binding
I6J71_38540	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J71_38555	COG2267	carboxylic ester hydrolase activity
I6J71_38585	COG0513	Belongs to the DEAD box helicase family
I6J71_38605	COG2095	MarC family integral membrane protein
I6J71_38610	COG0613	PHP domain protein
I6J71_38635	COG0598	Magnesium transport protein CorA
I6J71_38660	COG1309	transcriptional regulator
I6J71_38735	COG0330	HflC and HflK could
I6J71_38745	COG2239	Acts as a magnesium transporter
I6J71_38765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J71_38770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_38790	COG2814	Major facilitator Superfamily
I6J71_38795	COG0583	DNA-binding transcription factor activity
I6J71_38800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J71_38810	COG1024	Enoyl-CoA hydratase
I6J71_38815	COG2818	Glycosylase
I6J71_38840	COG1271	oxidase subunit
I6J71_38845	COG1294	oxidase, subunit
I6J71_38850	COG4988	ABC transporter
I6J71_38855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J71_38860	COG0463	Glycosyl transferase, family 2
I6J71_38875	COG1611	Belongs to the LOG family
I6J71_38880	COG2353	YceI-like domain
I6J71_38935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J71_38940	COG0778	Nitroreductase
I6J71_38940	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J71_38955	COG1725	Transcriptional regulator
I6J71_39000	COG0297	glycogen (starch) synthase activity
I6J71_39030	COG1316	TRANSCRIPTIONal
I6J71_39035	COG1316	TRANSCRIPTIONal
I6J71_39075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_39080	COG2267	carboxylic ester hydrolase activity
I6J71_39090	COG0667	Aldo Keto reductase
I6J71_39120	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_39125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J71_39185	COG2205	protein histidine kinase activity
I6J71_39195	COG0483	inositol monophosphate 1-phosphatase activity
I6J71_39205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_39240	COG1388	LysM domain
I6J71_39240	COG0791	NLP P60 protein
I6J71_39240	COG3103	Sh3 type 3 domain protein
I6J71_39255	COG3511	phospholipase C
I6J71_39290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_39305	COG1309	transcriptional regulator
I6J71_39330	COG0424	maF-like protein
I6J71_39335	COG1301	dicarboxylic acid transport
I6J71_39350	COG4770	biotin carboxylase activity
I6J71_39380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J71_39390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J71_39430	COG1473	amidohydrolase
I6J71_39430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_39455	COG0515	serine threonine protein kinase
I6J71_39500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J71_39530	COG1309	transcriptional regulator
I6J71_39540	COG0596	Alpha beta hydrolase
I6J71_39565	COG4191	Histidine kinase
I6J71_39570	COG0745	RESPONSE REGULATOR receiver
I6J71_39575	COG0475	glutathione-regulated potassium exporter activity
I6J71_39595	COG0667	Aldo Keto reductase
I6J71_39600	COG0667	Aldo Keto reductase
I6J71_39605	COG0789	Transcriptional regulator
I6J71_39675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J71_39680	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_39685	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_39715	COG2124	cytochrome p450
I6J71_39740	COG3842	ATPase activity
I6J71_39745	COG0395	ABC-type sugar transport system, permease component
I6J71_39750	COG1175	transmembrane transport
I6J71_39760	COG1063	alcohol dehydrogenase
I6J71_39770	COG1280	lysine exporter protein (LysE YggA)
I6J71_39785	COG2271	Major facilitator Superfamily
I6J71_39790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J71_39810	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J71_39820	COG3845	ABC transporter
I6J71_39825	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J71_39835	COG2009	succinate dehydrogenase
I6J71_39850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J71_39875	COG1295	ribonuclease BN
I6J71_39895	COG0180	Tryptophanyl-tRNA synthetase
I6J71_39965	COG2814	Major facilitator Superfamily
I6J71_39970	COG0640	Transcriptional regulator
I6J71_39975	COG2814	Major facilitator Superfamily
I6J71_39985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J71_40015	COG0587	DNA-directed DNA polymerase activity
I6J71_40030	COG0596	Alpha beta hydrolase
I6J71_40035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_40040	COG0138	bifunctional purine biosynthesis protein purh
I6J71_40065	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J71_40110	COG0515	serine threonine protein kinase
I6J71_40125	COG0697	spore germination
I6J71_40150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J71_40150	COG0519	Catalyzes the synthesis of GMP from XMP
I6J71_40170	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_40175	COG0277	FAD linked oxidase domain protein
I6J71_40195	COG0516	GMP reductase activity
I6J71_40250	COG1309	transcriptional regulator
I6J71_40255	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_40260	COG0459	protein refolding
I6J71_40265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J71_40270	COG0640	Transcriptional regulator
I6J71_40290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J71_40295	COG0456	acetyltransferase
I6J71_40305	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_40310	COG0825	malonyl-CoA metabolic process
I6J71_40310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J71_40315	COG0802	atpase or kinase
I6J71_40325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J71_40330	COG3842	ATPase activity
I6J71_40335	COG1070	Carbohydrate kinase
I6J71_40340	COG1349	DNA-binding transcription factor activity
I6J71_40345	COG2226	methyltransferase
I6J71_40360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J71_40400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J71_40410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J71_40440	COG0443	Heat shock 70 kDa protein
I6J71_40445	COG1674	ftsk spoiiie
I6J71_40455	COG1404	Belongs to the peptidase S8 family
I6J71_40490	COG0203	ribosomal protein L17
I6J71_40495	COG0202	RNA polymerase activity
I6J71_40500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J71_40505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J71_40515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J71_40520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J71_40525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J71_40535	COG0563	adenylate kinase activity
I6J71_40545	COG0200	Binds to the 23S rRNA
I6J71_40550	COG1841	ribosomal large subunit assembly
I6J71_40555	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J71_40560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J71_40565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J71_40570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J71_40580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J71_40585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J71_40590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J71_40595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J71_40600	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J71_40605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J71_40610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J71_40615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J71_40620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J71_40625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J71_40630	COG0089	rRNA binding
I6J71_40635	COG0088	Forms part of the polypeptide exit tunnel
I6J71_40640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J71_40645	COG0051	transcription antitermination factor activity, RNA binding
I6J71_40655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J71_40660	COG0049	tRNA binding
I6J71_40665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J71_40700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J71_40710	COG1605	Chorismate mutase
I6J71_40730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J71_40755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J71_40790	COG0081	regulation of translation
I6J71_40830	COG2030	dehydratase
I6J71_40835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J71_40870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J71_40885	COG1666	GTP binding
I6J71_40905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J71_40920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_40930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J71_40945	COG4310	Domain of unknown function (DUF2172)
I6J71_40955	COG1216	Glycosyl transferase, family 2
I6J71_40955	COG0463	Glycosyl transferase, family 2
I6J71_40965	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6J71_40970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J71_41030	COG0367	asparagine synthase
I6J71_41050	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J71_41065	COG1834	amidinotransferase
I6J71_41070	COG1522	sequence-specific DNA binding
I6J71_41075	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J71_41075	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J71_41080	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J71_41090	COG0142	geranyltranstransferase activity
I6J71_41110	COG1007	ATP synthesis coupled electron transport
I6J71_41120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J71_41125	COG0713	ATP synthesis coupled electron transport
I6J71_41130	COG0839	Belongs to the complex I subunit 6 family
I6J71_41135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J71_41140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J71_41145	COG1034	ATP synthesis coupled electron transport
I6J71_41150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J71_41160	COG0649	NAD binding
I6J71_41165	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J71_41170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J71_41185	COG2226	methyltransferase
I6J71_41190	COG0438	transferase activity, transferring glycosyl groups
I6J71_41220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J71_41240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_41250	COG1522	sequence-specific DNA binding
I6J71_41270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J71_41280	COG0785	Cytochrome C biogenesis protein
I6J71_41290	COG0406	alpha-ribazole phosphatase activity
I6J71_41295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J71_41325	COG0577	efflux transmembrane transporter activity
I6J71_41325	COG1136	(ABC) transporter
I6J71_41330	COG0577	efflux transmembrane transporter activity
I6J71_41330	COG1136	(ABC) transporter
I6J71_41335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J71_41375	COG1587	Uroporphyrinogen-III synthase
I6J71_41375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J71_41380	COG0181	hydroxymethylbilane synthase activity
I6J71_41385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J71_41390	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J71_41415	COG1595	DNA-templated transcription, initiation
I6J71_41450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J71_41485	COG5002	protein histidine kinase activity
I6J71_41490	COG0667	Aldo Keto reductase
I6J71_41505	COG0588	phosphoglycerate mutase activity
I6J71_41520	COG0438	transferase activity, transferring glycosyl groups
I6J71_41535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J71_41565	COG1064	alcohol dehydrogenase
I6J71_41585	COG2130	NADP-dependent
I6J71_41600	COG1174	glycine betaine transport
I6J71_41605	COG1174	glycine betaine transport
I6J71_41620	COG2986	histidine ammonia-lyase
I6J71_41675	COG2733	membrane
I6J71_41695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_41780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_41785	COG0667	Aldo Keto reductase
I6J71_41840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J71_41885	COG2124	cytochrome p450
I6J71_41890	COG1414	Transcriptional regulator
I6J71_41895	COG0789	Transcriptional regulator
I6J71_41905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J71_41910	COG2233	PERMEase
I6J71_41945	COG2814	Major facilitator Superfamily
I6J71_41950	COG0477	Major facilitator Superfamily
I6J71_42005	COG1278	Cold shock
I6J71_42030	COG0515	serine threonine protein kinase
I6J71_42035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_42065	COG0022	dehydrogenase e1 component
I6J71_42070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J71_42075	COG3199	ATP-NAD kinase
I6J71_42095	COG0028	Belongs to the TPP enzyme family
I6J71_42115	COG1335	isochorismatase
I6J71_42120	COG2124	cytochrome p450
I6J71_42145	COG5002	protein histidine kinase activity
I6J71_42210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_42215	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_42280	COG3033	Beta-eliminating lyase
I6J71_42330	COG2267	carboxylic ester hydrolase activity
I6J71_42335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_42350	COG1960	acyl-CoA dehydrogenase activity
I6J71_42355	COG1960	acyl-CoA dehydrogenase activity
I6J71_42370	COG1309	transcriptional regulator
I6J71_42375	COG2318	DinB family
I6J71_42410	COG1846	Transcriptional regulator
I6J71_42430	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J71_42430	COG1902	pentaerythritol trinitrate reductase activity
I6J71_42435	COG0287	Prephenate dehydrogenase
I6J71_42500	COG1131	(ABC) transporter
I6J71_42505	COG3559	Exporter of polyketide antibiotics
I6J71_42540	COG2172	sigma factor antagonist activity
I6J71_42555	COG0667	Aldo Keto reductase
I6J71_42560	COG3584	3D domain protein
I6J71_42560	COG3583	domain protein
I6J71_42580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J71_42590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J71_42635	COG0409	Hydrogenase expression formation protein
I6J71_42645	COG0375	protein maturation
I6J71_42655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6J71_42670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_42675	COG1720	tRNA m6t6A37 methyltransferase activity
I6J71_42715	COG1494	fructose-1,6-bisphosphatase
I6J71_42745	COG3279	Response regulator of the LytR AlgR family
I6J71_42760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_42765	COG1971	Probably functions as a manganese efflux pump
I6J71_42785	COG3588	fructose-bisphosphate aldolase
I6J71_42790	COG0583	DNA-binding transcription factor activity
I6J71_42800	COG0535	radical SAM domain protein
I6J71_42815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J71_42840	COG1309	transcriptional regulator
I6J71_42865	COG2124	cytochrome p450
I6J71_42875	COG1597	lipid kinase activity
I6J71_42905	COG0596	Alpha beta hydrolase
I6J71_43015	COG0582	viral genome integration into host DNA
I6J71_43035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_43045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J71_43065	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_43075	COG2186	Transcriptional regulator
I6J71_43090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J71_43095	COG1522	sequence-specific DNA binding
I6J71_43115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_43115	COG1672	PFAM Archaeal ATPase
I6J71_43120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J71_43130	COG2329	Antibiotic biosynthesis monooxygenase
I6J71_43150	COG1116	anion transmembrane transporter activity
I6J71_43155	COG3290	protein histidine kinase activity
I6J71_43160	COG4565	transcriptional regulatory protein
I6J71_43210	COG2234	aminopeptidase activity
I6J71_43215	COG1063	alcohol dehydrogenase
I6J71_43230	COG0596	Alpha beta hydrolase
I6J71_43240	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I6J71_43245	COG1086	Polysaccharide biosynthesis protein
I6J71_43250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J71_43260	COG2089	acid synthase
I6J71_43290	COG1216	Glycosyl transferase, family 2
I6J71_43320	COG1216	Glycosyl transferase, family 2
I6J71_43330	COG0277	FAD linked oxidase domain protein
I6J71_43335	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_43375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J71_43395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_43400	COG0561	phosphatase activity
I6J71_43435	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_43440	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_43450	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J71_43455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J71_43480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J71_43495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J71_43505	COG0579	oxidoreductase
I6J71_43525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J71_43530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_43535	COG0596	Alpha beta hydrolase
I6J71_43545	COG0754	glutathionylspermidine amidase activity
I6J71_43575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J71_43580	COG0406	alpha-ribazole phosphatase activity
I6J71_43590	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J71_43595	COG1072	(Pantothenic acid kinase))
I6J71_43610	COG4715	Zinc finger, swim domain protein
I6J71_43635	COG4988	ABC transporter
I6J71_43640	COG1294	oxidase, subunit
I6J71_43645	COG1271	oxidase subunit
I6J71_43710	COG1191	sigma factor activity
I6J71_43730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_43740	COG2814	Major facilitator Superfamily
I6J71_43765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_43775	COG3279	Response regulator of the LytR AlgR family
I6J71_43785	COG3275	phosphorelay sensor kinase activity
I6J71_43795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_43850	COG0438	transferase activity, transferring glycosyl groups
I6J71_43865	COG2197	response regulator
I6J71_43870	COG4585	Histidine kinase
I6J71_43880	COG0477	Major facilitator Superfamily
I6J71_43920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J71_43930	COG1073	alpha beta
I6J71_43930	COG2226	methyltransferase
I6J71_43950	COG1733	regulation of RNA biosynthetic process
I6J71_43965	COG1174	glycine betaine transport
I6J71_43990	COG1276	copper resistance
I6J71_43990	COG2372	response to copper ion
I6J71_44020	COG2211	Major facilitator Superfamily
I6J71_44030	COG1309	transcriptional regulator
I6J71_44035	COG0789	Transcriptional regulator
I6J71_44055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J71_44060	COG0702	epimerase
I6J71_44085	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_44090	COG4608	Belongs to the ABC transporter superfamily
I6J71_44095	COG0444	Belongs to the ABC transporter superfamily
I6J71_44100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_44110	COG0747	negative chemotaxis
I6J71_44115	COG2186	Transcriptional regulator
I6J71_44190	COG1716	ATPase activity
I6J71_44195	COG1716	ATPase activity
I6J71_44210	COG0768	penicillin binding
I6J71_44215	COG0515	serine threonine protein kinase
I6J71_44220	COG2815	serine threonine protein kinase
I6J71_44220	COG0515	serine threonine protein kinase
I6J71_44260	COG1131	(ABC) transporter
I6J71_44285	COG3764	Sortase (surface protein transpeptidase)
I6J71_44305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J71_44365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_44365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_44390	COG0673	inositol 2-dehydrogenase activity
I6J71_44405	COG1609	Transcriptional regulator
I6J71_44415	COG0800	Aldolase
I6J71_44420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J71_44430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J71_44435	COG1518	maintenance of DNA repeat elements
I6J71_44450	COG1857	crispr-associated protein
I6J71_44485	COG2801	Transposase and inactivated derivatives
I6J71_44560	COG0546	phosphoglycolate phosphatase activity
I6J71_44590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J71_44595	COG0187	DNA topoisomerase II activity
I6J71_44600	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J71_44605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J71_44610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J71_44615	COG0592	DNA-directed DNA polymerase activity
I6J71_44625	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J71_44635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J71_44640	COG0706	membrane insertase activity
I6J71_44655	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J71_44660	COG1192	Involved in chromosome partitioning
I6J71_44675	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J71_44700	COG3409	Peptidoglycan-binding domain 1 protein
I6J71_44700	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J71_44705	COG3118	belongs to the thioredoxin family
I6J71_44705	COG0492	ferredoxin-NADP+ reductase activity
I6J71_44720	COG1595	DNA-templated transcription, initiation
I6J71_44745	COG0617	tRNA 3'-terminal CCA addition
I6J71_44750	COG4585	Histidine kinase
I6J71_44790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J71_44810	COG0495	leucyl-tRNA aminoacylation
I6J71_44845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_44850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J71_44865	COG2197	response regulator
I6J71_44870	COG3920	Histidine kinase
I6J71_44890	COG3384	dioxygenase
I6J71_44935	COG0359	binds to the 23S rRNA
I6J71_44940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J71_44950	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J71_44985	COG0673	inositol 2-dehydrogenase activity
I6J71_44990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J71_44995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J71_45005	COG1695	Transcriptional regulator
I6J71_45015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_45025	COG2814	Major facilitator Superfamily
I6J71_45040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J71_45045	COG4221	oxidoreductase activity
I6J71_45050	COG0402	S-adenosylhomocysteine deaminase activity
I6J71_45065	COG2197	response regulator
I6J71_45075	COG1136	(ABC) transporter
I6J71_45085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J71_45100	COG1131	(ABC) transporter
I6J71_45115	COG2197	response regulator
I6J71_45120	COG4585	Histidine kinase
I6J71_45135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J71_45150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6J71_45160	COG1131	(ABC) transporter
I6J71_45205	COG0456	acetyltransferase
I6J71_45205	COG0454	-acetyltransferase
I6J71_45230	COG0183	Belongs to the thiolase family
I6J71_45235	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_45240	COG2030	dehydratase
I6J71_45245	COG1309	transcriptional regulator
I6J71_45290	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6J71_45295	COG4133	protoheme IX ABC transporter activity
I6J71_45310	COG2197	response regulator
I6J71_45340	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_45345	COG0022	dehydrogenase e1 component
I6J71_45355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J71_45365	COG0765	amino acid transport
I6J71_45370	COG1126	abc transporter atp-binding protein
I6J71_45410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J71_45425	COG1960	acyl-CoA dehydrogenase activity
I6J71_45430	COG2197	response regulator
I6J71_45435	COG3663	DNA glycosylase
I6J71_45450	COG0737	Belongs to the 5'-nucleotidase family
I6J71_45450	COG1525	nuclease
I6J71_45450	COG4085	toxin activity
I6J71_45475	COG3795	YCII-related domain
I6J71_45480	COG4941	Belongs to the sigma-70 factor family
I6J71_45525	COG0477	Major facilitator Superfamily
I6J71_45530	COG2340	Cysteine-rich secretory protein family
I6J71_45545	COG0247	lactate metabolic process
I6J71_45545	COG2181	nitrate reductase activity
I6J71_45550	COG2076	Multidrug Resistance protein
I6J71_45580	COG0443	Heat shock 70 kDa protein
I6J71_45585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J71_45590	COG0484	heat shock protein binding
I6J71_45595	COG0789	Transcriptional regulator
I6J71_45605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_45605	COG1017	nitric oxide dioxygenase activity
I6J71_45630	COG0542	response to heat
I6J71_45645	COG4221	oxidoreductase activity
I6J71_45650	COG1136	(ABC) transporter
I6J71_45650	COG0577	efflux transmembrane transporter activity
I6J71_45680	COG1302	Protein conserved in bacteria
I6J71_45690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_45730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_45735	COG0572	uridine kinase
I6J71_45740	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_45755	COG0586	Pfam SNARE associated Golgi protein
I6J71_45775	COG3467	pyridoxamine 5'-phosphate
I6J71_45780	COG0277	FAD linked oxidase domain protein
I6J71_45785	COG0586	Pfam SNARE associated Golgi protein
I6J71_45830	COG0667	Aldo Keto reductase
I6J71_45905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_45910	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_45915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_45920	COG2267	carboxylic ester hydrolase activity
I6J71_45925	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_45930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_45940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_45940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_45960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J71_45975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J71_45980	COG0584	glycerophosphoryl diester phosphodiesterase
I6J71_46025	COG0436	Aminotransferase
I6J71_46075	COG1175	transmembrane transport
I6J71_46080	COG0395	ABC-type sugar transport system, permease component
I6J71_46095	COG0800	Aldolase
I6J71_46115	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_46125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J71_46150	COG0765	amino acid transport
I6J71_46155	COG1126	abc transporter atp-binding protein
I6J71_46175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J71_46195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_46200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_46215	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_46240	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_46270	COG1309	transcriptional regulator
I6J71_46310	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J71_46315	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J71_46325	COG1132	(ABC) transporter
I6J71_46330	COG1132	(ABC) transporter
I6J71_46390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J71_46395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J71_46445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_46460	COG1984	allophanate hydrolase subunit 2
I6J71_46465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_46470	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6J71_46500	COG0745	RESPONSE REGULATOR receiver
I6J71_46525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J71_46545	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J71_46550	COG0596	Alpha beta hydrolase
I6J71_46580	COG1674	ftsk spoiiie
I6J71_46600	COG0464	growth
I6J71_46665	COG1397	ADP-ribosylglycohydrolase
I6J71_46670	COG2188	Transcriptional regulator
I6J71_46690	COG1063	alcohol dehydrogenase
I6J71_46715	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_46715	COG0596	Alpha beta hydrolase
I6J71_46720	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_46725	COG0431	NADPH-dependent FMN reductase
I6J71_46740	COG2197	response regulator
I6J71_46745	COG2267	carboxylic ester hydrolase activity
I6J71_46750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_46750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_46815	COG0346	lactoylglutathione lyase activity
I6J71_46830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_46835	COG4702	Belongs to the UPF0303 family
I6J71_46845	COG1473	amidohydrolase
I6J71_46870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_46875	COG2226	methyltransferase
I6J71_46895	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I6J71_46900	COG2843	Capsule synthesis protein
I6J71_46935	COG1674	ftsk spoiiie
I6J71_46955	COG0596	Alpha beta hydrolase
I6J71_47015	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_47045	COG0745	RESPONSE REGULATOR receiver
I6J71_47050	COG2205	protein histidine kinase activity
I6J71_47055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J71_47060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_47100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J71_47105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J71_47115	COG0463	Glycosyl transferase, family 2
I6J71_47145	COG0747	negative chemotaxis
I6J71_47150	COG0601	transmembrane transport
I6J71_47155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_47160	COG0444	Belongs to the ABC transporter superfamily
I6J71_47165	COG4608	Belongs to the ABC transporter superfamily
I6J71_47180	COG4941	Belongs to the sigma-70 factor family
I6J71_47195	COG0697	spore germination
I6J71_47200	COG0583	DNA-binding transcription factor activity
I6J71_47210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_47220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_47275	COG1690	Belongs to the RtcB family
I6J71_47295	COG0657	acetylesterase activity
I6J71_47305	COG1764	response to oxidative stress
I6J71_47310	COG0783	Belongs to the Dps family
I6J71_47320	COG0076	glutamate decarboxylase activity
I6J71_47325	COG1902	pentaerythritol trinitrate reductase activity