locus-tag	class	description
ORV05_00010	COG0688	phosphatidylethanolamine metabolic process
ORV05_00035	COG1278	Cold shock
ORV05_00045	COG0459	protein refolding
ORV05_00065	COG4948	Mandelate Racemase Muconate Lactonizing
ORV05_00070	COG0693	protein deglycase activity
ORV05_00090	COG1061	Type III restriction enzyme res subunit
ORV05_00110	COG1174	glycine betaine transport
ORV05_00115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ORV05_00120	COG0596	Alpha beta hydrolase
ORV05_00130	COG1116	anion transmembrane transporter activity
ORV05_00140	COG2018	Roadblock/LC7 domain
ORV05_00155	COG2018	Roadblock/LC7 domain
ORV05_00190	COG1388	LysM domain
ORV05_00200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ORV05_00205	COG1846	Transcriptional regulator
ORV05_00235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ORV05_00250	COG3304	Inner membrane component domain
ORV05_00255	COG0384	phenazine biosynthesis protein PhzF
ORV05_00260	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_00265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ORV05_00285	COG1278	Cold shock
ORV05_00320	COG2252	PERMEase
ORV05_00330	COG2814	Major facilitator Superfamily
ORV05_00355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ORV05_00385	COG0831	urea catabolic process
ORV05_00390	COG0832	Belongs to the urease beta subunit family
ORV05_00395	COG0804	urea catabolic process
ORV05_00405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ORV05_00410	COG0829	nickel cation binding
ORV05_00415	COG0259	pyridoxamine-phosphate oxidase activity
ORV05_00430	COG3883	PFAM NLP P60 protein
ORV05_00430	COG0791	NLP P60 protein
ORV05_00445	COG0789	Transcriptional regulator
ORV05_00490	COG1309	transcriptional regulator
ORV05_00495	COG2017	converts alpha-aldose to the beta-anomer
ORV05_00510	COG1960	acyl-CoA dehydrogenase activity
ORV05_00515	COG1309	transcriptional regulator
ORV05_00540	COG1668	transmembrane transport
ORV05_00545	COG4152	abc transporter atp-binding protein
ORV05_00595	COG1169	isochorismate synthase
ORV05_00600	COG2091	lysine biosynthetic process via aminoadipic acid
ORV05_00605	COG2267	carboxylic ester hydrolase activity
ORV05_00610	COG1960	acyl-CoA dehydrogenase activity
ORV05_00625	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_00630	COG1024	Enoyl-CoA hydratase
ORV05_00645	COG1321	iron dependent repressor
ORV05_00655	COG1064	alcohol dehydrogenase
ORV05_00685	COG5479	isomerase activity
ORV05_00685	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ORV05_00695	COG1247	-acetyltransferase
ORV05_00700	COG2226	methyltransferase
ORV05_00705	COG0640	Transcriptional regulator
ORV05_00710	COG0798	PFAM Bile acid sodium symporter
ORV05_00715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ORV05_00725	COG2814	Major facilitator Superfamily
ORV05_00730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ORV05_00740	COG2814	Major facilitator Superfamily
ORV05_00745	COG1819	glycosyl
ORV05_00755	COG1309	transcriptional regulator
ORV05_00765	COG1917	Cupin 2, conserved barrel domain protein
ORV05_00765	COG4977	sequence-specific DNA binding
ORV05_00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ORV05_00815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ORV05_00820	COG0477	Major facilitator Superfamily
ORV05_00830	COG1234	tRNA 3'-trailer cleavage
ORV05_00860	COG4941	Belongs to the sigma-70 factor family
ORV05_00865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ORV05_00875	COG0508	dehydrogenase complex catalyzes the overall conversion of
ORV05_00895	COG0525	valine-tRNA ligase activity
ORV05_00920	COG1136	(ABC) transporter
ORV05_00945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ORV05_00950	COG3973	AAA domain
ORV05_00955	COG0702	epimerase
ORV05_00960	COG1733	regulation of RNA biosynthetic process
ORV05_00990	COG2268	Band 7 protein
ORV05_00995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ORV05_01000	COG1902	pentaerythritol trinitrate reductase activity
ORV05_01010	COG0477	Major facilitator Superfamily
ORV05_01035	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_01040	COG3835	regulator
ORV05_01045	COG1063	alcohol dehydrogenase
ORV05_01110	COG0626	cystathionine gamma-synthase activity
ORV05_01120	COG3629	intracellular signal transduction
ORV05_01120	COG3903	Transcriptional regulator
ORV05_01135	COG1309	transcriptional regulator
ORV05_01155	COG0583	DNA-binding transcription factor activity
ORV05_01190	COG3903	Transcriptional regulator
ORV05_01190	COG3629	intracellular signal transduction
ORV05_01195	COG0596	Alpha beta hydrolase
ORV05_01225	COG0300	oxidoreductase activity
ORV05_01240	COG2197	response regulator
ORV05_01245	COG1131	(ABC) transporter
ORV05_01250	COG3559	Exporter of polyketide antibiotics
ORV05_01275	COG2197	response regulator
ORV05_01290	COG1349	DNA-binding transcription factor activity
ORV05_01300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ORV05_01325	COG0745	RESPONSE REGULATOR receiver
ORV05_01330	COG5002	protein histidine kinase activity
ORV05_01340	COG0315	cyclic pyranopterin monophosphate synthase activity
ORV05_01340	COG0521	Mo-molybdopterin cofactor biosynthetic process
ORV05_01365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ORV05_01370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ORV05_01380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ORV05_01410	COG1733	regulation of RNA biosynthetic process
ORV05_01430	COG2205	protein histidine kinase activity
ORV05_01440	COG2902	Dehydrogenase
ORV05_01445	COG1113	amino acid transport
ORV05_01450	COG2197	response regulator
ORV05_01470	COG0464	growth
ORV05_01480	COG1404	Belongs to the peptidase S8 family
ORV05_01485	COG1674	ftsk spoiiie
ORV05_01495	COG3266	domain, Protein
ORV05_01615	COG1309	transcriptional regulator
ORV05_01685	COG0515	serine threonine protein kinase
ORV05_01725	COG3290	protein histidine kinase activity
ORV05_01730	COG4565	transcriptional regulatory protein
ORV05_01750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ORV05_01755	COG0084	hydrolase, TatD family'
ORV05_01760	COG3583	domain protein
ORV05_01765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ORV05_01770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ORV05_01785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ORV05_01790	COG0488	(ABC) transporter
ORV05_01805	COG1733	regulation of RNA biosynthetic process
ORV05_01810	COG0702	epimerase
ORV05_01820	COG0583	DNA-binding transcription factor activity
ORV05_01825	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_01835	COG0193	aminoacyl-tRNA hydrolase activity
ORV05_01860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ORV05_01895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_01905	COG4221	oxidoreductase activity
ORV05_01925	COG2837	iron assimilation
ORV05_01935	COG0672	)-iron permease
ORV05_01955	COG0148	phosphopyruvate hydratase activity
ORV05_02000	COG1252	NADH dehydrogenase
ORV05_02085	COG2188	Transcriptional regulator
ORV05_02145	COG2890	protein-(glutamine-N5) methyltransferase activity
ORV05_02160	COG2259	Doxx family
ORV05_02185	COG0463	Glycosyl transferase, family 2
ORV05_02190	COG0791	NLP P60 protein
ORV05_02200	COG1501	Belongs to the glycosyl hydrolase 31 family
ORV05_02215	COG2814	Major facilitator Superfamily
ORV05_02265	COG0183	Belongs to the thiolase family
ORV05_02300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ORV05_02310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_02315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ORV05_02325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ORV05_02335	COG1331	Highly conserved protein containing a thioredoxin domain
ORV05_02345	COG5504	Zn-dependent protease
ORV05_02360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ORV05_02370	COG1131	(ABC) transporter
ORV05_02390	COG0667	Aldo Keto reductase
ORV05_02400	COG0745	RESPONSE REGULATOR receiver
ORV05_02405	COG2205	protein histidine kinase activity
ORV05_02415	COG1793	dna ligase
ORV05_02435	COG0114	fumarate hydratase activity
ORV05_02440	COG0492	ferredoxin-NADP+ reductase activity
ORV05_02450	COG1722	exodeoxyribonuclease VII activity
ORV05_02460	COG1570	exodeoxyribonuclease VII activity
ORV05_02470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ORV05_02490	COG0419	ATPase involved in DNA repair
ORV05_02500	COG0012	GTP binding
ORV05_02570	COG3012	SEC-C Motif Domain Protein
ORV05_02595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ORV05_02640	COG2154	pterin-4-alpha-carbinolamine dehydratase
ORV05_02650	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ORV05_02655	COG3842	ATPase activity
ORV05_02675	COG1131	(ABC) transporter
ORV05_02685	COG0745	RESPONSE REGULATOR receiver
ORV05_02690	COG2205	protein histidine kinase activity
ORV05_02700	COG0180	Tryptophanyl-tRNA synthetase
ORV05_02710	COG1217	gtp-binding protein TYPA
ORV05_02715	COG0747	negative chemotaxis
ORV05_02725	COG0601	transmembrane transport
ORV05_02740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ORV05_02760	COG1994	Peptidase M50
ORV05_02790	COG2835	tetraacyldisaccharide 4'-kinase activity
ORV05_02800	COG1482	cell wall glycoprotein biosynthetic process
ORV05_02810	COG3903	Transcriptional regulator
ORV05_02810	COG3629	intracellular signal transduction
ORV05_02835	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ORV05_02845	COG0745	RESPONSE REGULATOR receiver
ORV05_02850	COG5000	phosphorelay sensor kinase activity
ORV05_02850	COG5002	protein histidine kinase activity
ORV05_02855	COG5401	PFAM Sporulation and spore germination
ORV05_02865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ORV05_02870	COG0653	protein targeting
ORV05_02880	COG1011	Hydrolase
ORV05_02885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ORV05_02900	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_02915	COG1162	GTPase activity
ORV05_02920	COG2135	peptidase activity
ORV05_02930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ORV05_02935	COG1595	DNA-templated transcription, initiation
ORV05_02955	COG1597	lipid kinase activity
ORV05_02970	COG0406	alpha-ribazole phosphatase activity
ORV05_02980	COG4106	trans-aconitate 2-methyltransferase activity
ORV05_02985	COG2197	response regulator
ORV05_02990	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ORV05_02995	COG0281	malic enzyme
ORV05_03000	COG0517	IMP dehydrogenase activity
ORV05_03000	COG1125	glycine betaine transport
ORV05_03010	COG0567	Dehydrogenase, E1 component
ORV05_03010	COG0508	dehydrogenase complex catalyzes the overall conversion of
ORV05_03015	COG0277	FAD linked oxidase domain protein
ORV05_03020	COG1132	(ABC) transporter
ORV05_03040	COG0686	Belongs to the AlaDH PNT family
ORV05_03060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ORV05_03070	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ORV05_03070	COG2508	Transcriptional regulator
ORV05_03085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ORV05_03105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ORV05_03115	COG1960	acyl-CoA dehydrogenase activity
ORV05_03130	COG3243	poly(R)-hydroxyalkanoic acid synthase
ORV05_03140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ORV05_03170	COG1960	acyl-CoA dehydrogenase activity
ORV05_03175	COG1960	acyl-CoA dehydrogenase activity
ORV05_03190	COG0183	Belongs to the thiolase family
ORV05_03195	COG1250	3-hydroxyacyl-CoA dehydrogenase
ORV05_03195	COG1024	Enoyl-CoA hydratase
ORV05_03200	COG0028	Belongs to the TPP enzyme family
ORV05_03215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ORV05_03225	COG0473	3-isopropylmalate dehydrogenase activity
ORV05_03235	COG0583	DNA-binding transcription factor activity
ORV05_03280	COG0435	Glutathione S-transferase
ORV05_03300	COG0596	Alpha beta hydrolase
ORV05_03320	COG1414	Transcriptional regulator
ORV05_03345	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_03355	COG3340	Belongs to the peptidase S51 family
ORV05_03375	COG0484	heat shock protein binding
ORV05_03390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ORV05_03415	COG2124	cytochrome p450
ORV05_03430	COG1136	(ABC) transporter
ORV05_03430	COG0577	efflux transmembrane transporter activity
ORV05_03435	COG1136	(ABC) transporter
ORV05_03450	COG0745	RESPONSE REGULATOR receiver
ORV05_03455	COG2205	protein histidine kinase activity
ORV05_03510	COG1316	TRANSCRIPTIONal
ORV05_03530	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_03540	COG3844	kynureninase activity
ORV05_03545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ORV05_03555	COG0514	ATP-dependent DNA helicase (RecQ)
ORV05_03560	COG0366	Alpha amylase catalytic
ORV05_03590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ORV05_03590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ORV05_03605	COG2072	flavoprotein involved in K transport
ORV05_03640	COG2814	Major facilitator Superfamily
ORV05_03645	COG1846	Transcriptional regulator
ORV05_03655	COG0492	ferredoxin-NADP+ reductase activity
ORV05_03660	COG0321	lipoyl(octanoyl) transferase activity
ORV05_03665	COG1595	DNA-templated transcription, initiation
ORV05_03735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ORV05_03740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ORV05_03745	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ORV05_03755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ORV05_03760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ORV05_03785	COG0346	lactoylglutathione lyase activity
ORV05_03790	COG0183	Belongs to the thiolase family
ORV05_03800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ORV05_03810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_03815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ORV05_03820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ORV05_03825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ORV05_03830	COG1879	ABC-type sugar transport system periplasmic component
ORV05_03835	COG1172	Belongs to the binding-protein-dependent transport system permease family
ORV05_03850	COG1609	Transcriptional regulator
ORV05_03855	COG3537	Alpha-1,2-mannosidase
ORV05_03875	COG1846	Transcriptional regulator
ORV05_03895	COG0058	SHG alpha-glucan phosphorylase activity
ORV05_03910	COG1119	ATPase activity
ORV05_03920	COG2226	methyltransferase
ORV05_03930	COG0412	Dienelactone hydrolase
ORV05_03940	COG0515	serine threonine protein kinase
ORV05_03960	COG0277	FAD linked oxidase domain protein
ORV05_03975	COG2910	NAD(P)H-binding
ORV05_03995	COG1522	sequence-specific DNA binding
ORV05_04010	COG3629	intracellular signal transduction
ORV05_04010	COG3903	Transcriptional regulator
ORV05_04015	COG2183	response to ionizing radiation
ORV05_04040	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ORV05_04055	COG0745	RESPONSE REGULATOR receiver
ORV05_04060	COG5002	protein histidine kinase activity
ORV05_04070	COG1476	TRANSCRIPTIONal
ORV05_04080	COG1131	(ABC) transporter
ORV05_04105	COG0778	Nitroreductase
ORV05_04115	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ORV05_04140	COG1797	cobyrinic acid a,c-diamide synthase activity
ORV05_04150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ORV05_04165	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ORV05_04170	COG1492	cobalamin metabolic process
ORV05_04180	COG0069	glutamate synthase activity
ORV05_04180	COG0070	glutamate synthase
ORV05_04180	COG0067	glutamate synthase
ORV05_04185	COG3971	2-oxopent-4-enoate hydratase activity
ORV05_04195	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ORV05_04195	COG0235	Class ii aldolase
ORV05_04200	COG0251	oxidation-reduction process
ORV05_04205	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ORV05_04210	COG3483	tryptophan 2,3-dioxygenase activity
ORV05_04215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ORV05_04225	COG0583	DNA-binding transcription factor activity
ORV05_04230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ORV05_04255	COG3268	Saccharopine dehydrogenase
ORV05_04260	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_04260	COG2030	dehydratase
ORV05_04295	COG0316	Belongs to the HesB IscA family
ORV05_04320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ORV05_04325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ORV05_04330	COG0183	Belongs to the thiolase family
ORV05_04335	COG3485	protocatechuate 3,4-dioxygenase
ORV05_04340	COG3485	protocatechuate 3,4-dioxygenase
ORV05_04350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ORV05_04355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ORV05_04360	COG1414	Transcriptional regulator
ORV05_04365	COG0746	molybdenum cofactor guanylyltransferase activity
ORV05_04435	COG0154	amidase activity
ORV05_04460	COG0174	glutamine synthetase
ORV05_04465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ORV05_04480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ORV05_04480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ORV05_04485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ORV05_04490	COG1760	l-serine dehydratase
ORV05_04495	COG2186	Transcriptional regulator
ORV05_04510	COG2814	Major facilitator Superfamily
ORV05_04530	COG0789	Transcriptional regulator
ORV05_04530	COG4978	Transcriptional regulator
ORV05_04565	COG0577	efflux transmembrane transporter activity
ORV05_04565	COG1136	(ABC) transporter
ORV05_04570	COG4585	Histidine kinase
ORV05_04575	COG2197	response regulator
ORV05_04580	COG4221	oxidoreductase activity
ORV05_04585	COG1643	Atp-dependent helicase
ORV05_04595	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_04615	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_04625	COG2409	Drug exporters of the RND superfamily
ORV05_04640	COG1609	Transcriptional regulator
ORV05_04655	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_04665	COG4974	Belongs to the 'phage' integrase family
ORV05_04710	COG2197	response regulator
ORV05_04755	COG0037	tRNA processing
ORV05_04825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ORV05_04825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ORV05_05075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ORV05_05135	COG0542	response to heat
ORV05_05150	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_05155	COG1309	transcriptional regulator
ORV05_05160	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ORV05_05180	COG0442	prolyl-tRNA aminoacylation
ORV05_05195	COG2197	response regulator
ORV05_05230	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ORV05_05255	COG1404	Belongs to the peptidase S8 family
ORV05_05275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ORV05_05280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ORV05_05295	COG3201	nicotinamide mononucleotide transporter
ORV05_05305	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ORV05_05395	COG2188	Transcriptional regulator
ORV05_05450	COG1104	cysteine desulfurase activity
ORV05_05455	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_05465	COG0587	DNA-directed DNA polymerase activity
ORV05_05485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ORV05_05490	COG1376	ErfK ybiS ycfS ynhG family protein
ORV05_05510	COG0586	Pfam SNARE associated Golgi protein
ORV05_05515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ORV05_05540	COG0321	lipoyl(octanoyl) transferase activity
ORV05_05545	COG0671	phosphoesterase, PA-phosphatase related
ORV05_05555	COG0508	dehydrogenase complex catalyzes the overall conversion of
ORV05_05560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ORV05_05585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ORV05_05595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ORV05_05595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ORV05_05600	COG0667	Aldo Keto reductase
ORV05_05620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ORV05_05630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ORV05_05640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ORV05_05655	COG1845	cytochrome c oxidase, subunit III
ORV05_05660	COG2010	Cytochrome c
ORV05_05670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ORV05_05700	COG0438	transferase activity, transferring glycosyl groups
ORV05_05715	COG2124	cytochrome p450
ORV05_05720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ORV05_05725	COG0659	secondary active sulfate transmembrane transporter activity
ORV05_05730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ORV05_05735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ORV05_05750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ORV05_05760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ORV05_05765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ORV05_05780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ORV05_05795	COG2197	response regulator
ORV05_05805	COG0697	spore germination
ORV05_05815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ORV05_05820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ORV05_05825	COG0131	Imidazoleglycerol-phosphate dehydratase
ORV05_05835	COG2409	Drug exporters of the RND superfamily
ORV05_05840	COG1309	transcriptional regulator
ORV05_05850	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ORV05_05860	COG3959	Transketolase, thiamine diphosphate binding domain
ORV05_05865	COG3958	Transketolase
ORV05_05875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ORV05_05880	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ORV05_05895	COG0107	imidazoleglycerol-phosphate synthase activity
ORV05_05915	COG1309	transcriptional regulator
ORV05_05920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ORV05_05930	COG0134	indole-3-glycerol-phosphate synthase activity
ORV05_05935	COG0133	tryptophan synthase activity
ORV05_05940	COG0159	tryptophan synthase activity
ORV05_05960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ORV05_05995	COG1120	ATPase activity
ORV05_06000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ORV05_06005	COG4558	Periplasmic binding protein
ORV05_06010	COG0069	glutamate synthase activity
ORV05_06010	COG0067	glutamate synthase
ORV05_06010	COG0070	glutamate synthase
ORV05_06035	COG1309	transcriptional regulator
ORV05_06045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ORV05_06060	COG2815	serine threonine protein kinase
ORV05_06060	COG0515	serine threonine protein kinase
ORV05_06085	COG0142	geranyltranstransferase activity
ORV05_06090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ORV05_06105	COG0583	DNA-binding transcription factor activity
ORV05_06185	COG0242	peptide deformylase activity
ORV05_06190	COG1201	RNA secondary structure unwinding
ORV05_06195	COG0443	Heat shock 70 kDa protein
ORV05_06205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ORV05_06210	COG2137	regulation of response to DNA damage stimulus
ORV05_06230	COG0596	Alpha beta hydrolase
ORV05_06240	COG0800	Aldolase
ORV05_06260	COG1053	succinate dehydrogenase
ORV05_06285	COG1940	carbohydrate kinase activity
ORV05_06295	COG1175	transmembrane transport
ORV05_06305	COG3842	ATPase activity
ORV05_06310	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ORV05_06315	COG0765	amino acid transport
ORV05_06320	COG0765	amino acid transport
ORV05_06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ORV05_06330	COG1126	abc transporter atp-binding protein
ORV05_06340	COG2337	Toxic component of a toxin-antitoxin (TA) module
ORV05_06345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ORV05_06360	COG2814	Major facilitator Superfamily
ORV05_06370	COG1802	Transcriptional regulator
ORV05_06380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ORV05_06390	COG1196	nuclear chromosome segregation
ORV05_06400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ORV05_06405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ORV05_06420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ORV05_06430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ORV05_06440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ORV05_06445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ORV05_06450	COG4977	sequence-specific DNA binding
ORV05_06480	COG0477	Major facilitator Superfamily
ORV05_06485	COG1505	serine-type exopeptidase activity
ORV05_06515	COG2197	response regulator
ORV05_06520	COG4585	Histidine kinase
ORV05_06540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ORV05_06550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ORV05_06555	COG0179	Fumarylacetoacetate (FAA) hydrolase
ORV05_06560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ORV05_06570	COG0123	including yeast histone deacetylase and acetoin utilization protein
ORV05_06585	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_06590	COG1960	acyl-CoA dehydrogenase activity
ORV05_06595	COG1960	acyl-CoA dehydrogenase activity
ORV05_06610	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_06625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ORV05_06645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ORV05_06670	COG1022	Amp-dependent synthetase and ligase
ORV05_06700	COG1940	carbohydrate kinase activity
ORV05_06730	COG0535	radical SAM domain protein
ORV05_06740	COG0446	pyridine nucleotide-disulphide oxidoreductase
ORV05_06740	COG1902	pentaerythritol trinitrate reductase activity
ORV05_06750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ORV05_06755	COG0644	oxidoreductase
ORV05_06770	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_06790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ORV05_06790	COG2010	Cytochrome c
ORV05_06810	COG1278	Cold shock
ORV05_06825	COG1573	uracil-dna glycosylase
ORV05_06855	COG3285	dna ligase
ORV05_06855	COG1793	dna ligase
ORV05_06860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ORV05_06875	COG2890	protein-(glutamine-N5) methyltransferase activity
ORV05_06925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_06930	COG1929	Belongs to the glycerate kinase type-1 family
ORV05_06970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ORV05_06990	COG1309	transcriptional regulator
ORV05_07010	COG1946	Acyl-CoA thioesterase
ORV05_07030	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ORV05_07030	COG1672	PFAM Archaeal ATPase
ORV05_07035	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_07065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ORV05_07085	COG1566	PFAM secretion protein HlyD family protein
ORV05_07095	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ORV05_07110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ORV05_07125	COG2018	Roadblock/LC7 domain
ORV05_07140	COG1703	isobutyryl-CoA mutase activity
ORV05_07140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ORV05_07140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ORV05_07165	COG1309	transcriptional regulator
ORV05_07170	COG1960	acyl-CoA dehydrogenase activity
ORV05_07175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ORV05_07180	COG4279	zinc finger
ORV05_07185	COG0657	acetylesterase activity
ORV05_07195	COG1960	acyl-CoA dehydrogenase activity
ORV05_07200	COG1960	acyl-CoA dehydrogenase activity
ORV05_07205	COG2030	dehydratase
ORV05_07225	COG2030	dehydratase
ORV05_07245	COG1053	succinate dehydrogenase
ORV05_07250	COG1960	acyl-CoA dehydrogenase activity
ORV05_07255	COG2267	carboxylic ester hydrolase activity
ORV05_07260	COG0346	lactoylglutathione lyase activity
ORV05_07265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ORV05_07285	COG1960	acyl-CoA dehydrogenase activity
ORV05_07290	COG1960	acyl-CoA dehydrogenase activity
ORV05_07295	COG1960	acyl-CoA dehydrogenase activity
ORV05_07300	COG1024	Enoyl-CoA hydratase
ORV05_07305	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_07310	COG1960	acyl-CoA dehydrogenase activity
ORV05_07315	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_07320	COG1309	transcriptional regulator
ORV05_07330	COG1473	amidohydrolase
ORV05_07340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ORV05_07355	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_07360	COG0702	epimerase
ORV05_07365	COG1733	regulation of RNA biosynthetic process
ORV05_07370	COG0183	Belongs to the thiolase family
ORV05_07375	COG2124	cytochrome p450
ORV05_07425	COG2070	2-Nitropropane dioxygenase
ORV05_07440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ORV05_07440	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ORV05_07450	COG1490	D-aminoacyl-tRNA deacylase activity
ORV05_07455	COG2890	protein-(glutamine-N5) methyltransferase activity
ORV05_07465	COG2318	DinB family
ORV05_07470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ORV05_07485	COG2313	pseudouridylate synthase activity
ORV05_07490	COG1942	4-Oxalocrotonate Tautomerase
ORV05_07515	COG0174	glutamine synthetase
ORV05_07525	COG0531	amino acid
ORV05_07540	COG0483	inositol monophosphate 1-phosphatase activity
ORV05_07560	COG0756	dUTP diphosphatase activity
ORV05_07570	COG1280	lysine exporter protein (LysE YggA)
ORV05_07595	COG0569	domain protein
ORV05_07600	COG0531	amino acid
ORV05_07605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ORV05_07620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ORV05_07625	COG0745	RESPONSE REGULATOR receiver
ORV05_07630	COG2205	protein histidine kinase activity
ORV05_07635	COG1024	Enoyl-CoA hydratase
ORV05_07635	COG1250	3-hydroxyacyl-CoA dehydrogenase
ORV05_07640	COG0183	Belongs to the thiolase family
ORV05_07650	COG2197	response regulator
ORV05_07665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ORV05_07675	COG3253	May function as heme-dependent peroxidase
ORV05_07680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ORV05_07685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ORV05_07745	COG0384	phenazine biosynthesis protein PhzF
ORV05_07765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ORV05_07885	COG2815	serine threonine protein kinase
ORV05_07885	COG0515	serine threonine protein kinase
ORV05_07975	COG0582	viral genome integration into host DNA
ORV05_08050	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_08070	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_08100	COG1228	amidohydrolase
ORV05_08120	COG1733	regulation of RNA biosynthetic process
ORV05_08155	COG0640	Transcriptional regulator
ORV05_08160	COG0702	epimerase
ORV05_08170	COG0583	DNA-binding transcription factor activity
ORV05_08190	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_08205	COG2205	protein histidine kinase activity
ORV05_08205	COG2198	Histidine kinase
ORV05_08205	COG0784	Response regulator, receiver
ORV05_08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ORV05_08210	COG2197	response regulator
ORV05_08235	COG3387	PFAM Glycoside hydrolase 15-related
ORV05_08280	COG2267	carboxylic ester hydrolase activity
ORV05_08305	COG0477	Major facilitator Superfamily
ORV05_08310	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_08315	COG1309	transcriptional regulator
ORV05_08320	COG0477	Major facilitator Superfamily
ORV05_08335	COG3971	2-oxopent-4-enoate hydratase activity
ORV05_08360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_08365	COG0179	Fumarylacetoacetate (FAA) hydrolase
ORV05_08375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_08385	COG0179	Fumarylacetoacetate (FAA) hydrolase
ORV05_08390	COG1802	Transcriptional regulator
ORV05_08415	COG3209	COG3209 Rhs family protein
ORV05_08475	COG1309	transcriptional regulator
ORV05_08480	COG2207	Transcriptional regulator
ORV05_08575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_08585	COG2197	response regulator
ORV05_08605	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_08610	COG0477	Major facilitator Superfamily
ORV05_08620	COG1414	Transcriptional regulator
ORV05_08625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ORV05_08635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ORV05_08690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ORV05_08705	COG3012	SEC-C Motif Domain Protein
ORV05_08710	COG1414	Transcriptional regulator
ORV05_08760	COG1674	ftsk spoiiie
ORV05_08775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ORV05_08785	COG0653	protein targeting
ORV05_08815	COG0464	growth
ORV05_08835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ORV05_08840	COG1140	nitrate reductase beta subunit
ORV05_08855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ORV05_08860	COG0022	dehydrogenase e1 component
ORV05_08865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ORV05_08885	COG3903	Transcriptional regulator
ORV05_08885	COG3629	intracellular signal transduction
ORV05_08895	COG2226	methyltransferase
ORV05_08915	COG2860	membrane
ORV05_08930	COG4977	sequence-specific DNA binding
ORV05_08945	COG2197	response regulator
ORV05_08950	COG4585	Histidine kinase
ORV05_08955	COG0577	efflux transmembrane transporter activity
ORV05_08955	COG1136	(ABC) transporter
ORV05_08980	COG2124	cytochrome p450
ORV05_09005	COG5002	protein histidine kinase activity
ORV05_09035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_09045	COG4941	Belongs to the sigma-70 factor family
ORV05_09080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ORV05_09080	COG2755	lipolytic protein G-D-S-L family
ORV05_09090	COG1595	DNA-templated transcription, initiation
ORV05_09130	COG0706	membrane insertase activity
ORV05_09135	COG0701	Predicted permease
ORV05_09140	COG2814	Major facilitator Superfamily
ORV05_09155	COG0346	lactoylglutathione lyase activity
ORV05_09165	COG2080	2 iron, 2 sulfur cluster binding
ORV05_09170	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ORV05_09175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ORV05_09180	COG0702	epimerase
ORV05_09220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ORV05_09230	COG2197	response regulator
ORV05_09245	COG2267	carboxylic ester hydrolase activity
ORV05_09260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ORV05_09310	COG2197	response regulator
ORV05_09340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ORV05_09350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ORV05_09355	COG0604	alcohol dehydrogenase
ORV05_09355	COG3321	synthase
ORV05_09355	COG0604	alcohol dehydrogenase
ORV05_09355	COG3321	synthase
ORV05_09375	COG1136	(ABC) transporter
ORV05_09375	COG0577	efflux transmembrane transporter activity
ORV05_09400	COG3321	synthase
ORV05_09400	COG0604	alcohol dehydrogenase
ORV05_09425	COG1309	transcriptional regulator
ORV05_09440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ORV05_09450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_09485	COG2255	four-way junction helicase activity
ORV05_09505	COG1129	ABC transporter
ORV05_09510	COG1172	Belongs to the binding-protein-dependent transport system permease family
ORV05_09515	COG1879	ABC-type sugar transport system periplasmic component
ORV05_09535	COG1609	Transcriptional regulator
ORV05_09540	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
ORV05_09545	COG1070	Carbohydrate kinase
ORV05_09550	COG1285	pathogenesis
ORV05_09610	COG1301	dicarboxylic acid transport
ORV05_09615	COG3290	protein histidine kinase activity
ORV05_09620	COG4565	transcriptional regulatory protein
ORV05_09650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ORV05_09655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ORV05_09660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ORV05_09665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ORV05_09670	COG0072	phenylalanine-tRNA ligase activity
ORV05_09670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ORV05_09695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ORV05_09700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ORV05_09705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ORV05_09710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ORV05_09720	COG1438	arginine binding
ORV05_09725	COG0137	argininosuccinate synthase activity
ORV05_09730	COG0165	Argininosuccinate lyase
ORV05_09740	COG2094	Belongs to the DNA glycosylase MPG family
ORV05_09745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ORV05_09775	COG0647	UMP catabolic process
ORV05_09790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ORV05_09815	COG0667	Aldo Keto reductase
ORV05_09825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ORV05_09830	COG0504	CTP synthase activity
ORV05_09835	COG0494	nUDIX hydrolase
ORV05_09860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ORV05_09865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ORV05_09875	COG0514	ATP-dependent DNA helicase (RecQ)
ORV05_09880	COG0475	glutathione-regulated potassium exporter activity
ORV05_09890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ORV05_09900	COG1160	GTP binding
ORV05_09925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ORV05_09930	COG1414	Transcriptional regulator
ORV05_09955	COG0484	heat shock protein binding
ORV05_09970	COG3284	Transcriptional regulator
ORV05_09980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ORV05_10000	COG0489	protein tyrosine kinase activity
ORV05_10000	COG2151	metal-sulfur cluster biosynthetic enzyme
ORV05_10005	COG1063	alcohol dehydrogenase
ORV05_10010	COG0459	protein refolding
ORV05_10040	COG1024	Enoyl-CoA hydratase
ORV05_10065	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_10070	COG0506	proline dehydrogenase activity
ORV05_10080	COG0477	Major facilitator Superfamily
ORV05_10090	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ORV05_10165	COG2205	protein histidine kinase activity
ORV05_10190	COG0714	Associated with various cellular activities
ORV05_10205	COG0515	serine threonine protein kinase
ORV05_10220	COG1653	transport
ORV05_10240	COG0673	inositol 2-dehydrogenase activity
ORV05_10250	COG1609	Transcriptional regulator
ORV05_10255	COG1082	Xylose isomerase domain protein TIM barrel
ORV05_10275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ORV05_10285	COG3718	enzyme involved in inositol metabolism
ORV05_10290	COG3962	Belongs to the TPP enzyme family
ORV05_10295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ORV05_10305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ORV05_10310	COG0488	(ABC) transporter
ORV05_10335	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ORV05_10340	COG1132	(ABC) transporter
ORV05_10355	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_10380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ORV05_10390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_10400	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_10430	COG0697	spore germination
ORV05_10435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ORV05_10500	COG0477	Major facilitator Superfamily
ORV05_10510	COG1309	transcriptional regulator
ORV05_10520	COG4260	virion core protein, lumpy skin disease virus
ORV05_10535	COG2318	DinB family
ORV05_10545	COG4221	oxidoreductase activity
ORV05_10560	COG0366	Alpha amylase catalytic
ORV05_10565	COG3833	ABC-type maltose transport systems, permease component
ORV05_10575	COG2182	Extracellular solute-binding protein
ORV05_10615	COG0395	ABC-type sugar transport system, permease component
ORV05_10630	COG1609	Transcriptional regulator
ORV05_10635	COG1472	Belongs to the glycosyl hydrolase 3 family
ORV05_10655	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_10660	COG1881	PFAM PEBP family protein
ORV05_10690	COG1472	Belongs to the glycosyl hydrolase 3 family
ORV05_10705	COG1175	transmembrane transport
ORV05_10730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ORV05_10735	COG1960	acyl-CoA dehydrogenase activity
ORV05_10745	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_10750	COG1960	acyl-CoA dehydrogenase activity
ORV05_10755	COG1960	acyl-CoA dehydrogenase activity
ORV05_10780	COG1116	anion transmembrane transporter activity
ORV05_10790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ORV05_10805	COG1957	nucleoside hydrolase
ORV05_10810	COG2186	Transcriptional regulator
ORV05_10835	COG0596	Alpha beta hydrolase
ORV05_10850	COG1764	response to oxidative stress
ORV05_10855	COG1846	Transcriptional regulator
ORV05_10860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ORV05_10880	COG0477	Major facilitator Superfamily
ORV05_10890	COG0583	DNA-binding transcription factor activity
ORV05_10945	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_10955	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ORV05_10965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ORV05_10970	COG0145	ligase activity
ORV05_10975	COG4647	ligase activity
ORV05_10985	COG0145	ligase activity
ORV05_10990	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ORV05_10995	COG0583	DNA-binding transcription factor activity
ORV05_11010	COG0183	Belongs to the thiolase family
ORV05_11015	COG1309	transcriptional regulator
ORV05_11065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ORV05_11065	COG1017	nitric oxide dioxygenase activity
ORV05_11080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ORV05_11095	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_11130	COG0640	Transcriptional regulator
ORV05_11145	COG4716	Myosin-crossreactive antigen
ORV05_11155	COG0628	permease
ORV05_11170	COG0247	lactate metabolic process
ORV05_11170	COG0277	FAD linked oxidase domain protein
ORV05_11180	COG1454	alcohol dehydrogenase
ORV05_11205	COG0583	DNA-binding transcription factor activity
ORV05_11215	COG0504	CTP synthase activity
ORV05_11220	COG0596	Alpha beta hydrolase
ORV05_11250	COG4264	IucA IucC family
ORV05_11260	COG0019	diaminopimelate decarboxylase activity
ORV05_11285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ORV05_11290	COG1595	DNA-templated transcription, initiation
ORV05_11315	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_11340	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_11380	COG0300	oxidoreductase activity
ORV05_11410	COG2124	cytochrome p450
ORV05_11470	COG0573	inorganic phosphate transmembrane transporter activity
ORV05_11535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ORV05_11560	COG2072	flavoprotein involved in K transport
ORV05_11570	COG0657	acetylesterase activity
ORV05_11605	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_11620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ORV05_11625	COG1960	acyl-CoA dehydrogenase activity
ORV05_11630	COG2197	response regulator
ORV05_11635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ORV05_11670	COG3665	Urea carboxylase-associated protein
ORV05_11680	COG2132	Multicopper oxidase
ORV05_11700	COG1595	DNA-templated transcription, initiation
ORV05_11715	COG1802	Transcriptional regulator
ORV05_11720	COG2814	Major facilitator Superfamily
ORV05_11725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ORV05_11745	COG1309	transcriptional regulator
ORV05_11750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ORV05_11755	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_11770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ORV05_11780	COG0583	DNA-binding transcription factor activity
ORV05_11790	COG2814	Major facilitator Superfamily
ORV05_11795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ORV05_11820	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ORV05_11835	COG0587	DNA-directed DNA polymerase activity
ORV05_11860	COG1073	alpha beta
ORV05_11900	COG2267	carboxylic ester hydrolase activity
ORV05_11915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ORV05_11945	COG4762	Protein conserved in bacteria
ORV05_11970	COG1511	domain protein
ORV05_11980	COG1309	transcriptional regulator
ORV05_11985	COG1414	Transcriptional regulator
ORV05_11990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_12000	COG0179	Fumarylacetoacetate (FAA) hydrolase
ORV05_12025	COG0596	Alpha beta hydrolase
ORV05_12040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ORV05_12045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ORV05_12050	COG1959	2 iron, 2 sulfur cluster binding
ORV05_12060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ORV05_12085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ORV05_12090	COG0137	argininosuccinate synthase activity
ORV05_12095	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_12130	COG0702	epimerase
ORV05_12145	COG1215	transferase activity, transferring glycosyl groups
ORV05_12165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ORV05_12165	COG2124	cytochrome p450
ORV05_12185	COG2755	lipolytic protein G-D-S-L family
ORV05_12205	COG4104	PAAR repeat-containing protein
ORV05_12205	COG3209	COG3209 Rhs family protein
ORV05_12245	COG2409	Drug exporters of the RND superfamily
ORV05_12260	COG2837	iron assimilation
ORV05_12270	COG0438	transferase activity, transferring glycosyl groups
ORV05_12305	COG0515	serine threonine protein kinase
ORV05_12325	COG2181	nitrate reductase activity
ORV05_12325	COG0247	lactate metabolic process
ORV05_12335	COG0326	Molecular chaperone. Has ATPase activity
ORV05_12370	COG2261	transglycosylase associated protein
ORV05_12375	COG2814	Major facilitator Superfamily
ORV05_12390	COG0515	serine threonine protein kinase
ORV05_12390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ORV05_12420	COG3246	L-lysine catabolic process to acetate
ORV05_12440	COG0477	Major facilitator Superfamily
ORV05_12450	COG1846	Transcriptional regulator
ORV05_12455	COG3321	synthase
ORV05_12455	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_12455	COG0604	alcohol dehydrogenase
ORV05_12480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ORV05_12490	COG4977	sequence-specific DNA binding
ORV05_12510	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ORV05_12545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_12550	COG2124	cytochrome p450
ORV05_12585	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ORV05_12605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ORV05_12615	COG0535	radical SAM domain protein
ORV05_12620	COG0535	radical SAM domain protein
ORV05_12625	COG1971	Probably functions as a manganese efflux pump
ORV05_12670	COG2318	DinB family
ORV05_12705	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_12730	COG2197	response regulator
ORV05_12735	COG4585	Histidine kinase
ORV05_12790	COG0667	Aldo Keto reductase
ORV05_12800	COG2197	response regulator
ORV05_12815	COG2233	PERMEase
ORV05_12825	COG3209	COG3209 Rhs family protein
ORV05_12850	COG2259	Doxx family
ORV05_12855	COG1335	isochorismatase
ORV05_12880	COG0789	Transcriptional regulator
ORV05_12890	COG0583	DNA-binding transcription factor activity
ORV05_12895	COG0395	ABC-type sugar transport system, permease component
ORV05_12905	COG1653	transport
ORV05_12910	COG3842	ATPase activity
ORV05_12915	COG1234	tRNA 3'-trailer cleavage
ORV05_12925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ORV05_12985	COG1022	Amp-dependent synthetase and ligase
ORV05_12990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ORV05_12990	COG3433	isochorismatase activity
ORV05_12990	COG2226	methyltransferase
ORV05_13035	COG2223	nitrite transmembrane transporter activity
ORV05_13040	COG2207	Transcriptional regulator
ORV05_13045	COG4166	transmembrane transport
ORV05_13050	COG0601	transmembrane transport
ORV05_13055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ORV05_13060	COG0444	Belongs to the ABC transporter superfamily
ORV05_13065	COG4608	Belongs to the ABC transporter superfamily
ORV05_13070	COG1846	Transcriptional regulator
ORV05_13110	COG3321	synthase
ORV05_13110	COG0604	alcohol dehydrogenase
ORV05_13115	COG3321	synthase
ORV05_13115	COG0604	alcohol dehydrogenase
ORV05_13115	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_13145	COG2267	carboxylic ester hydrolase activity
ORV05_13160	COG0038	chloride channel
ORV05_13165	COG1846	Transcriptional regulator
ORV05_13170	COG0076	glutamate decarboxylase activity
ORV05_13200	COG2130	NADP-dependent
ORV05_13215	COG1404	Belongs to the peptidase S8 family
ORV05_13240	COG1960	acyl-CoA dehydrogenase activity
ORV05_13255	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_13270	COG0583	DNA-binding transcription factor activity
ORV05_13290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ORV05_13295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ORV05_13300	COG0657	acetylesterase activity
ORV05_13315	COG1309	transcriptional regulator
ORV05_13335	COG2267	carboxylic ester hydrolase activity
ORV05_13365	COG4941	Belongs to the sigma-70 factor family
ORV05_13395	COG2205	protein histidine kinase activity
ORV05_13450	COG2072	flavoprotein involved in K transport
ORV05_13455	COG1309	transcriptional regulator
ORV05_13490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ORV05_13500	COG2197	response regulator
ORV05_13505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ORV05_13510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_13515	COG0596	Alpha beta hydrolase
ORV05_13560	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_13565	COG1250	3-hydroxyacyl-CoA dehydrogenase
ORV05_13565	COG1024	Enoyl-CoA hydratase
ORV05_13580	COG2197	response regulator
ORV05_13585	COG4585	Histidine kinase
ORV05_13595	COG2132	Multicopper oxidase
ORV05_13645	COG0583	DNA-binding transcription factor activity
ORV05_13665	COG2272	Belongs to the type-B carboxylesterase lipase family
ORV05_13695	COG0596	Alpha beta hydrolase
ORV05_13750	COG0667	Aldo Keto reductase
ORV05_13760	COG0667	Aldo Keto reductase
ORV05_13810	COG2814	Major facilitator Superfamily
ORV05_13860	COG0596	Alpha beta hydrolase
ORV05_13880	COG2267	carboxylic ester hydrolase activity
ORV05_13885	COG4552	Acetyltransferase involved in intracellular survival and related
ORV05_13890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ORV05_13895	COG1960	acyl-CoA dehydrogenase activity
ORV05_13905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_13915	COG1902	pentaerythritol trinitrate reductase activity
ORV05_13920	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_13970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_13990	COG1733	regulation of RNA biosynthetic process
ORV05_13995	COG1250	3-hydroxyacyl-CoA dehydrogenase
ORV05_13995	COG1024	Enoyl-CoA hydratase
ORV05_14065	COG4585	Histidine kinase
ORV05_14070	COG2197	response regulator
ORV05_14080	COG1132	(ABC) transporter
ORV05_14095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ORV05_14095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ORV05_14115	COG0183	Belongs to the thiolase family
ORV05_14120	COG1250	3-hydroxyacyl-CoA dehydrogenase
ORV05_14125	COG0583	DNA-binding transcription factor activity
ORV05_14130	COG0596	Alpha beta hydrolase
ORV05_14170	COG2186	Transcriptional regulator
ORV05_14190	COG1960	acyl-CoA dehydrogenase activity
ORV05_14195	COG1024	Enoyl-CoA hydratase
ORV05_14200	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_14210	COG2267	carboxylic ester hydrolase activity
ORV05_14225	COG0431	NADPH-dependent FMN reductase
ORV05_14235	COG0747	negative chemotaxis
ORV05_14240	COG0601	transmembrane transport
ORV05_14245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ORV05_14255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_14260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_14265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_14270	COG3634	alkyl hydroperoxide reductase activity
ORV05_14295	COG1733	regulation of RNA biosynthetic process
ORV05_14300	COG0640	Transcriptional regulator
ORV05_14345	COG3511	phospholipase C
ORV05_14380	COG2115	Belongs to the xylose isomerase family
ORV05_14385	COG1846	Transcriptional regulator
ORV05_14385	COG0456	acetyltransferase
ORV05_14395	COG0508	dehydrogenase complex catalyzes the overall conversion of
ORV05_14400	COG0508	dehydrogenase complex catalyzes the overall conversion of
ORV05_14400	COG0022	dehydrogenase e1 component
ORV05_14405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ORV05_14410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ORV05_14435	COG0697	spore germination
ORV05_14510	COG3387	PFAM Glycoside hydrolase 15-related
ORV05_14515	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_14520	COG1063	alcohol dehydrogenase
ORV05_14535	COG1595	DNA-templated transcription, initiation
ORV05_14540	COG1228	amidohydrolase
ORV05_14550	COG0640	Transcriptional regulator
ORV05_14590	COG0501	Belongs to the peptidase M48B family
ORV05_14600	COG0789	Transcriptional regulator
ORV05_14605	COG5504	Zn-dependent protease
ORV05_14610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ORV05_14640	COG4109	DRTGG domain
ORV05_14655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ORV05_14660	COG0517	IMP dehydrogenase activity
ORV05_14705	COG0640	Transcriptional regulator
ORV05_14740	COG2326	polyphosphate kinase activity
ORV05_14820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ORV05_14835	COG1366	Belongs to the anti-sigma-factor antagonist family
ORV05_14840	COG1366	Belongs to the anti-sigma-factor antagonist family
ORV05_14845	COG2172	sigma factor antagonist activity
ORV05_14865	COG0517	IMP dehydrogenase activity
ORV05_14890	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_14905	COG0306	phosphate transporter
ORV05_14910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ORV05_14930	COG1309	transcriptional regulator
ORV05_14955	COG1472	Belongs to the glycosyl hydrolase 3 family
ORV05_14965	COG1522	sequence-specific DNA binding
ORV05_14975	COG0300	oxidoreductase activity
ORV05_14990	COG0515	serine threonine protein kinase
ORV05_14990	COG2815	serine threonine protein kinase
ORV05_15000	COG1136	(ABC) transporter
ORV05_15005	COG1136	(ABC) transporter
ORV05_15020	COG0697	spore germination
ORV05_15025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ORV05_15030	COG3226	Transcriptional regulator
ORV05_15045	COG1796	DNA polymerase
ORV05_15045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ORV05_15060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ORV05_15065	COG0022	dehydrogenase e1 component
ORV05_15085	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_15095	COG0640	Transcriptional regulator
ORV05_15105	COG4941	Belongs to the sigma-70 factor family
ORV05_15115	COG1509	lysine 2,3-aminomutase activity
ORV05_15130	COG0463	Glycosyl transferase, family 2
ORV05_15140	COG1435	thymidine kinase activity
ORV05_15150	COG0584	glycerophosphoryl diester phosphodiesterase
ORV05_15175	COG0740	serine-type endopeptidase activity
ORV05_15185	COG0667	Aldo Keto reductase
ORV05_15190	COG1309	transcriptional regulator
ORV05_15205	COG0640	Transcriptional regulator
ORV05_15225	COG0640	Transcriptional regulator
ORV05_15245	COG2226	methyltransferase
ORV05_15280	COG4585	Histidine kinase
ORV05_15315	COG0702	epimerase
ORV05_15325	COG4257	antibiotic catabolic process
ORV05_15335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_15375	COG1595	DNA-templated transcription, initiation
ORV05_15385	COG1309	transcriptional regulator
ORV05_15395	COG0662	Cupin 2, conserved barrel domain protein
ORV05_15420	COG0583	DNA-binding transcription factor activity
ORV05_15430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ORV05_15440	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_15490	COG0657	acetylesterase activity
ORV05_15515	COG4585	Histidine kinase
ORV05_15520	COG2197	response regulator
ORV05_15570	COG4941	Belongs to the sigma-70 factor family
ORV05_15575	COG3795	YCII-related domain
ORV05_15580	COG0640	Transcriptional regulator
ORV05_15585	COG0477	Major facilitator Superfamily
ORV05_15595	COG1819	glycosyl
ORV05_15620	COG0789	Transcriptional regulator
ORV05_15625	COG4221	oxidoreductase activity
ORV05_15630	COG0583	DNA-binding transcription factor activity
ORV05_15655	COG0596	Alpha beta hydrolase
ORV05_15690	COG1366	Belongs to the anti-sigma-factor antagonist family
ORV05_15720	COG1309	transcriptional regulator
ORV05_15725	COG0477	Major facilitator Superfamily
ORV05_15750	COG1733	regulation of RNA biosynthetic process
ORV05_15765	COG0823	Involved in the tonB-independent uptake of proteins
ORV05_15765	COG4946	Tricorn protease homolog
ORV05_15765	COG1506	peptidase
ORV05_15770	COG1619	proteins homologs of microcin C7 resistance protein MccF
ORV05_15775	COG0154	amidase activity
ORV05_15815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ORV05_15820	COG0601	transmembrane transport
ORV05_15830	COG2362	D-Aminopeptidase
ORV05_15850	COG3537	Alpha-1,2-mannosidase
ORV05_15865	COG0039	L-malate dehydrogenase activity
ORV05_15870	COG0339	signal peptide processing
ORV05_15880	COG1968	undecaprenyl-diphosphatase activity
ORV05_15885	COG0667	Aldo Keto reductase
ORV05_15900	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_15930	COG1595	DNA-templated transcription, initiation
ORV05_15940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ORV05_15945	COG0583	DNA-binding transcription factor activity
ORV05_15955	COG0667	Aldo Keto reductase
ORV05_15960	COG1216	Glycosyl transferase, family 2
ORV05_15980	COG0559	Belongs to the binding-protein-dependent transport system permease family
ORV05_15995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ORV05_16015	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_16020	COG0183	Belongs to the thiolase family
ORV05_16025	COG1960	acyl-CoA dehydrogenase activity
ORV05_16030	COG1960	acyl-CoA dehydrogenase activity
ORV05_16035	COG1024	Enoyl-CoA hydratase
ORV05_16040	COG1024	Enoyl-CoA hydratase
ORV05_16050	COG4977	sequence-specific DNA binding
ORV05_16075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ORV05_16080	COG4608	Belongs to the ABC transporter superfamily
ORV05_16095	COG4166	transmembrane transport
ORV05_16125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_16135	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_16140	COG2072	flavoprotein involved in K transport
ORV05_16150	COG1376	ErfK ybiS ycfS ynhG family protein
ORV05_16200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ORV05_16205	COG2011	ABC-type metal ion transport system permease component
ORV05_16225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ORV05_16230	COG1690	Belongs to the RtcB family
ORV05_16240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ORV05_16255	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ORV05_16255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_16260	COG0427	acetyl-CoA hydrolase
ORV05_16290	COG2608	mercury ion transmembrane transporter activity
ORV05_16320	COG0515	serine threonine protein kinase
ORV05_16325	COG0235	Class ii aldolase
ORV05_16405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ORV05_16430	COG1802	Transcriptional regulator
ORV05_16470	COG0640	Transcriptional regulator
ORV05_16475	COG2837	iron assimilation
ORV05_16480	COG2847	Copper chaperone PCu(A)C
ORV05_16485	COG4991	sh3 domain protein
ORV05_16505	COG2890	protein-(glutamine-N5) methyltransferase activity
ORV05_16515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ORV05_16525	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ORV05_16540	COG0375	protein maturation
ORV05_16550	COG0409	Hydrogenase expression formation protein
ORV05_16555	COG0298	carbon dioxide binding
ORV05_16585	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ORV05_16595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ORV05_16605	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ORV05_16610	COG1309	transcriptional regulator
ORV05_16615	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_16645	COG2197	response regulator
ORV05_16655	COG4948	Mandelate Racemase Muconate Lactonizing
ORV05_16700	COG3511	phospholipase C
ORV05_16730	COG0242	peptide deformylase activity
ORV05_16745	COG0745	RESPONSE REGULATOR receiver
ORV05_16760	COG2208	phosphoserine phosphatase activity
ORV05_16760	COG2770	Histidine kinase
ORV05_16770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_16795	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ORV05_16800	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ORV05_16805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ORV05_16845	COG0477	Major facilitator Superfamily
ORV05_16865	COG1172	Belongs to the binding-protein-dependent transport system permease family
ORV05_16885	COG4948	Mandelate Racemase Muconate Lactonizing
ORV05_16890	COG0179	Fumarylacetoacetate (FAA) hydrolase
ORV05_16920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ORV05_16935	COG0346	lactoylglutathione lyase activity
ORV05_16950	COG2814	Major facilitator Superfamily
ORV05_16965	COG0028	Belongs to the TPP enzyme family
ORV05_16975	COG0477	Major facilitator Superfamily
ORV05_16980	COG1335	isochorismatase
ORV05_17005	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_17010	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_17020	COG1024	Enoyl-CoA hydratase
ORV05_17040	COG1937	Protein conserved in bacteria
ORV05_17050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_17050	COG3453	Protein conserved in bacteria
ORV05_17060	COG2855	membrane
ORV05_17065	COG2188	Transcriptional regulator
ORV05_17085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ORV05_17100	COG2072	flavoprotein involved in K transport
ORV05_17105	COG3226	Transcriptional regulator
ORV05_17110	COG0439	Biotin carboxylase
ORV05_17125	COG4977	sequence-specific DNA binding
ORV05_17130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ORV05_17140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ORV05_17145	COG1063	alcohol dehydrogenase
ORV05_17170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ORV05_17225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ORV05_17240	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_17260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ORV05_17295	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_17320	COG2226	methyltransferase
ORV05_17325	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ORV05_17345	COG1725	Transcriptional regulator
ORV05_17350	COG1131	(ABC) transporter
ORV05_17375	COG3220	belongs to the UPF0276 family
ORV05_17395	COG1846	Transcriptional regulator
ORV05_17425	COG1960	acyl-CoA dehydrogenase activity
ORV05_17430	COG1960	acyl-CoA dehydrogenase activity
ORV05_17435	COG2226	methyltransferase
ORV05_17440	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ORV05_17450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ORV05_17480	COG1309	transcriptional regulator
ORV05_17485	COG0583	DNA-binding transcription factor activity
ORV05_17500	COG1584	GPR1 FUN34 yaaH family protein
ORV05_17505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ORV05_17510	COG3275	phosphorelay sensor kinase activity
ORV05_17515	COG3279	Response regulator of the LytR AlgR family
ORV05_17525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ORV05_17535	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_17540	COG1309	transcriptional regulator
ORV05_17545	COG0596	Alpha beta hydrolase
ORV05_17555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ORV05_17560	COG1063	alcohol dehydrogenase
ORV05_17565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ORV05_17580	COG1105	Belongs to the carbohydrate kinase PfkB family
ORV05_17585	COG1349	DNA-binding transcription factor activity
ORV05_17605	COG1309	transcriptional regulator
ORV05_17620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ORV05_17625	COG1960	acyl-CoA dehydrogenase activity
ORV05_17640	COG1024	Enoyl-CoA hydratase
ORV05_17675	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_17700	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_17720	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_17755	COG2860	membrane
ORV05_17770	COG1472	Belongs to the glycosyl hydrolase 3 family
ORV05_17790	COG1268	BioY protein
ORV05_17805	COG1122	ATPase activity
ORV05_17835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ORV05_17855	COG1138	Cytochrome C-type biogenesis protein
ORV05_17860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ORV05_17865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ORV05_17875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ORV05_17895	COG3474	cytochrome
ORV05_17900	COG2010	Cytochrome c
ORV05_17910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ORV05_17915	COG0247	lactate metabolic process
ORV05_17915	COG0277	FAD linked oxidase domain protein
ORV05_17920	COG0028	Belongs to the TPP enzyme family
ORV05_17935	COG0437	4 iron, 4 sulfur cluster binding
ORV05_17985	COG2205	protein histidine kinase activity
ORV05_17990	COG0745	RESPONSE REGULATOR receiver
ORV05_18035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ORV05_18085	COG2423	ornithine cyclodeaminase activity
ORV05_18090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ORV05_18095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ORV05_18100	COG2175	clavaminate synthase activity
ORV05_18105	COG3629	intracellular signal transduction
ORV05_18105	COG3903	Transcriptional regulator
ORV05_18130	COG3629	intracellular signal transduction
ORV05_18130	COG3903	Transcriptional regulator
ORV05_18135	COG3629	intracellular signal transduction
ORV05_18135	COG3903	Transcriptional regulator
ORV05_18140	COG0730	response to heat
ORV05_18145	COG0175	sulfate reduction
ORV05_18150	COG0529	Catalyzes the synthesis of activated sulfate
ORV05_18150	COG2895	sulfate adenylyltransferase (ATP) activity
ORV05_18175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ORV05_18180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ORV05_18225	COG1793	dna ligase
ORV05_18230	COG0697	spore germination
ORV05_18235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ORV05_18270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_18280	COG1172	Belongs to the binding-protein-dependent transport system permease family
ORV05_18285	COG1172	Belongs to the binding-protein-dependent transport system permease family
ORV05_18290	COG1129	ABC transporter
ORV05_18295	COG1879	ABC-type sugar transport system periplasmic component
ORV05_18300	COG1609	Transcriptional regulator
ORV05_18315	COG2271	Major facilitator Superfamily
ORV05_18320	COG0583	DNA-binding transcription factor activity
ORV05_18325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ORV05_18335	COG0477	Major facilitator Superfamily
ORV05_18340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ORV05_18345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ORV05_18355	COG1414	Transcriptional regulator
ORV05_18360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ORV05_18365	COG0501	Belongs to the peptidase M48B family
ORV05_18370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ORV05_18370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ORV05_18395	COG1316	TRANSCRIPTIONal
ORV05_18410	COG1132	(ABC) transporter
ORV05_18425	COG0488	(ABC) transporter
ORV05_18435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ORV05_18440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_18445	COG5001	Diguanylate cyclase
ORV05_18445	COG4251	negative regulation of phosphorylation
ORV05_18445	COG3706	GGDEF domain
ORV05_18445	COG2203	Gaf domain
ORV05_18450	COG5640	endopeptidase activity
ORV05_18455	COG2151	metal-sulfur cluster biosynthetic enzyme
ORV05_18460	COG0822	iron-sulfur transferase activity
ORV05_18470	COG0396	ATPase activity
ORV05_18495	COG1131	(ABC) transporter
ORV05_18530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ORV05_18535	COG1657	PFAM Prenyltransferase squalene oxidase
ORV05_18545	COG1233	COG1233 Phytoene dehydrogenase and related
ORV05_18555	COG1562	ergosterol biosynthetic process
ORV05_18560	COG3835	regulator
ORV05_18570	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_18585	COG0109	protoheme IX farnesyltransferase activity
ORV05_18595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ORV05_18600	COG0166	Belongs to the GPI family
ORV05_18615	COG0363	glucosamine-6-phosphate deaminase activity
ORV05_18620	COG4585	Histidine kinase
ORV05_18635	COG0149	triose-phosphate isomerase activity
ORV05_18640	COG0126	phosphoglycerate kinase activity
ORV05_18645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ORV05_18690	COG1846	Transcriptional regulator
ORV05_18700	COG0463	Glycosyl transferase, family 2
ORV05_18710	COG2205	protein histidine kinase activity
ORV05_18715	COG0745	RESPONSE REGULATOR receiver
ORV05_18725	COG1481	regulation of sporulation
ORV05_18735	COG1660	Displays ATPase and GTPase activities
ORV05_18740	COG0322	excinuclease ABC activity
ORV05_18745	COG0708	Exodeoxyribonuclease III
ORV05_18755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ORV05_18760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ORV05_18760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ORV05_18785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ORV05_18795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ORV05_18805	COG1758	RNA polymerase activity
ORV05_18810	COG0194	GDP metabolic process
ORV05_18820	COG0284	orotidine-5'-phosphate decarboxylase activity
ORV05_18830	COG0505	Belongs to the CarA family
ORV05_18845	COG0540	Belongs to the ATCase OTCase family
ORV05_18850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ORV05_18860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ORV05_18865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ORV05_18870	COG0006	proline dipeptidase activity
ORV05_18885	COG0346	lactoylglutathione lyase activity
ORV05_18890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ORV05_18895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ORV05_18900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ORV05_18905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ORV05_18935	COG1263	PTS System
ORV05_18935	COG2190	(PTS) system
ORV05_18935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ORV05_18940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ORV05_18945	COG2188	Transcriptional regulator
ORV05_18950	COG1263	PTS System
ORV05_18965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ORV05_18970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ORV05_18985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ORV05_19000	COG2084	Dehydrogenase
ORV05_19030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ORV05_19045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_19060	COG0386	Belongs to the glutathione peroxidase family
ORV05_19085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ORV05_19115	COG2018	Roadblock/LC7 domain
ORV05_19145	COG1510	regulation of RNA biosynthetic process
ORV05_19150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ORV05_19180	COG1940	carbohydrate kinase activity
ORV05_19185	COG4214	carbohydrate transport
ORV05_19195	COG4213	ABC transporter substrate-binding protein
ORV05_19220	COG2186	Transcriptional regulator
ORV05_19250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ORV05_19260	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_19270	COG1809	phosphosulfolactate synthase activity
ORV05_19280	COG0406	alpha-ribazole phosphatase activity
ORV05_19295	COG0009	L-threonylcarbamoyladenylate synthase
ORV05_19355	COG3226	Transcriptional regulator
ORV05_19375	COG2353	YceI-like domain
ORV05_19425	COG1357	PFAM Pentapeptide repeats (8 copies)
ORV05_19440	COG0789	Transcriptional regulator
ORV05_19460	COG2315	Protein conserved in bacteria
ORV05_19480	COG3469	chitinase activity
ORV05_19510	COG3833	ABC-type maltose transport systems, permease component
ORV05_19520	COG0477	Major facilitator Superfamily
ORV05_19530	COG2197	response regulator
ORV05_19535	COG4585	Histidine kinase
ORV05_19545	COG3511	phospholipase C
ORV05_19550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ORV05_19565	COG3903	Transcriptional regulator
ORV05_19565	COG3629	intracellular signal transduction
ORV05_19575	COG4585	Histidine kinase
ORV05_19600	COG2186	Transcriptional regulator
ORV05_19640	COG5280	Phage tail tape measure protein TP901
ORV05_19640	COG3953	SLT domain
ORV05_19650	COG0483	inositol monophosphate 1-phosphatase activity
ORV05_19655	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ORV05_19665	COG3813	Protein conserved in bacteria
ORV05_19695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_19710	COG1414	Transcriptional regulator
ORV05_19730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ORV05_19750	COG3547	Transposase (IS116 IS110 IS902 family)
ORV05_19760	COG0745	RESPONSE REGULATOR receiver
ORV05_19795	COG0667	Aldo Keto reductase
ORV05_19820	COG0517	IMP dehydrogenase activity
ORV05_19820	COG0617	tRNA 3'-terminal CCA addition
ORV05_19820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ORV05_19825	COG0574	Belongs to the PEP-utilizing enzyme family
ORV05_19825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ORV05_19850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ORV05_19865	COG1271	oxidase subunit
ORV05_19870	COG1294	oxidase, subunit
ORV05_19875	COG4988	ABC transporter
ORV05_19880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ORV05_19890	COG0517	IMP dehydrogenase activity
ORV05_19890	COG0617	tRNA 3'-terminal CCA addition
ORV05_19890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ORV05_19915	COG2197	response regulator
ORV05_19930	COG0642	Histidine kinase
ORV05_19970	COG4152	abc transporter atp-binding protein
ORV05_19975	COG1668	transmembrane transport
ORV05_19980	COG4552	Acetyltransferase involved in intracellular survival and related
ORV05_19990	COG4552	Acetyltransferase involved in intracellular survival and related
ORV05_20015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ORV05_20025	COG2378	regulation of single-species biofilm formation
ORV05_20030	COG2378	regulation of single-species biofilm formation
ORV05_20035	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ORV05_20045	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ORV05_20050	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ORV05_20080	COG1222	aaa ATPase
ORV05_20100	COG0517	IMP dehydrogenase activity
ORV05_20100	COG1994	Peptidase M50
ORV05_20115	COG1192	Involved in chromosome partitioning
ORV05_20120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ORV05_20125	COG0140	phosphoribosyl-ATP diphosphatase activity
ORV05_20135	COG0646	methionine synthase
ORV05_20135	COG1410	methionine synthase
ORV05_20150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ORV05_20155	COG0488	(ABC) transporter
ORV05_20160	COG0215	cysteine-tRNA ligase activity
ORV05_20180	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ORV05_20190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ORV05_20195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ORV05_20205	COG0477	Major facilitator Superfamily
ORV05_20210	COG0745	RESPONSE REGULATOR receiver
ORV05_20225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ORV05_20230	COG2304	oxidoreductase activity
ORV05_20240	COG0714	Associated with various cellular activities
ORV05_20245	COG0746	molybdenum cofactor guanylyltransferase activity
ORV05_20250	COG3883	PFAM NLP P60 protein
ORV05_20250	COG0791	NLP P60 protein
ORV05_20255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ORV05_20265	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ORV05_20270	COG3511	phospholipase C
ORV05_20280	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ORV05_20285	COG0121	glutamine amidotransferase
ORV05_20290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ORV05_20295	COG3572	ergothioneine biosynthetic process
ORV05_20335	COG0656	L-ascorbic acid biosynthetic process
ORV05_20360	COG1716	ATPase activity
ORV05_20385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ORV05_20395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ORV05_20400	COG1648	precorrin-2 dehydrogenase activity
ORV05_20400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ORV05_20420	COG2211	Major facilitator Superfamily
ORV05_20430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_20465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ORV05_20480	COG0539	negative regulation of cytoplasmic translation
ORV05_20485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ORV05_20495	COG3547	Transposase (IS116 IS110 IS902 family)
ORV05_20500	COG1122	ATPase activity
ORV05_20505	COG1511	domain protein
ORV05_20510	COG1309	transcriptional regulator
ORV05_20525	COG2207	Transcriptional regulator
ORV05_20535	COG2050	protein possibly involved in aromatic compounds catabolism
ORV05_20585	COG3631	Ketosteroid isomerase-related protein
ORV05_20590	COG0702	epimerase
ORV05_20605	COG4221	oxidoreductase activity
ORV05_20615	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_20690	COG2124	cytochrome p450
ORV05_20700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_20705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ORV05_20750	COG2226	methyltransferase
ORV05_20760	COG0531	amino acid
ORV05_20765	COG3851	Histidine kinase
ORV05_20770	COG2197	response regulator
ORV05_20775	COG1131	(ABC) transporter
ORV05_20810	COG2378	regulation of single-species biofilm formation
ORV05_20835	COG1959	2 iron, 2 sulfur cluster binding
ORV05_20895	COG0604	alcohol dehydrogenase
ORV05_20910	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ORV05_20915	COG2272	Belongs to the type-B carboxylesterase lipase family
ORV05_20945	COG2040	homocysteine
ORV05_20960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ORV05_21010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ORV05_21015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ORV05_21020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ORV05_21035	COG2255	four-way junction helicase activity
ORV05_21040	COG0632	four-way junction helicase activity
ORV05_21045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ORV05_21055	COG0217	transcriptional regulatory protein
ORV05_21060	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ORV05_21065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ORV05_21075	COG3608	succinylglutamate desuccinylase aspartoacylase
ORV05_21075	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ORV05_21085	COG0438	transferase activity, transferring glycosyl groups
ORV05_21090	COG1560	Kdo2-lipid A biosynthetic process
ORV05_21100	COG1846	Transcriptional regulator
ORV05_21115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ORV05_21120	COG0778	Nitroreductase
ORV05_21130	COG1215	transferase activity, transferring glycosyl groups
ORV05_21160	COG1215	transferase activity, transferring glycosyl groups
ORV05_21165	COG1216	Glycosyl transferase, family 2
ORV05_21175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ORV05_21265	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_21265	COG3321	synthase
ORV05_21265	COG0604	alcohol dehydrogenase
ORV05_21285	COG1733	regulation of RNA biosynthetic process
ORV05_21290	COG0477	Major facilitator Superfamily
ORV05_21315	COG0183	Belongs to the thiolase family
ORV05_21320	COG1309	transcriptional regulator
ORV05_21340	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_21345	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_21360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ORV05_21365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ORV05_21380	COG1024	Enoyl-CoA hydratase
ORV05_21395	COG1024	Enoyl-CoA hydratase
ORV05_21405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ORV05_21410	COG1741	Belongs to the pirin family
ORV05_21415	COG0028	Belongs to the TPP enzyme family
ORV05_21425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ORV05_21430	COG0583	DNA-binding transcription factor activity
ORV05_21440	COG1309	transcriptional regulator
ORV05_21465	COG0789	Transcriptional regulator
ORV05_21480	COG0823	Involved in the tonB-independent uptake of proteins
ORV05_21480	COG1506	peptidase
ORV05_21480	COG4946	Tricorn protease homolog
ORV05_21535	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ORV05_21535	COG0237	dephospho-CoA kinase activity
ORV05_21550	COG1316	TRANSCRIPTIONal
ORV05_21555	COG3386	PFAM SMP-30 Gluconolaconase
ORV05_21570	COG1172	Belongs to the binding-protein-dependent transport system permease family
ORV05_21575	COG1129	ABC transporter
ORV05_21585	COG2814	Major facilitator Superfamily
ORV05_21590	COG0697	spore germination
ORV05_21595	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ORV05_21600	COG0583	DNA-binding transcription factor activity
ORV05_21660	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ORV05_21670	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_21675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ORV05_21675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ORV05_21680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ORV05_21690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ORV05_21695	COG2192	nodulation
ORV05_21705	COG0438	transferase activity, transferring glycosyl groups
ORV05_21725	COG0542	response to heat
ORV05_21745	COG1309	transcriptional regulator
ORV05_21765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ORV05_21775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_21790	COG0673	inositol 2-dehydrogenase activity
ORV05_21800	COG0673	inositol 2-dehydrogenase activity
ORV05_21810	COG0395	ABC-type sugar transport system, permease component
ORV05_21815	COG1175	transmembrane transport
ORV05_21820	COG0673	inositol 2-dehydrogenase activity
ORV05_21825	COG0657	acetylesterase activity
ORV05_21860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ORV05_21865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ORV05_21870	COG3263	regulation of cellular component size
ORV05_21875	COG1872	DUF167
ORV05_21880	COG0640	Transcriptional regulator
ORV05_21890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ORV05_21895	COG0477	Major facilitator Superfamily
ORV05_21900	COG0640	Transcriptional regulator
ORV05_21920	COG1799	cell septum assembly
ORV05_21930	COG1496	oxidoreductase activity
ORV05_21940	COG2318	DinB family
ORV05_21950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ORV05_21955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ORV05_21960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ORV05_21970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ORV05_21975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ORV05_21995	COG0768	penicillin binding
ORV05_22005	COG0275	rRNA processing
ORV05_22010	COG2001	Belongs to the MraZ family
ORV05_22035	COG0714	Associated with various cellular activities
ORV05_22045	COG1305	Transglutaminase-like
ORV05_22055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ORV05_22065	COG1192	Involved in chromosome partitioning
ORV05_22070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ORV05_22080	COG0167	dihydroorotate dehydrogenase activity
ORV05_22095	COG1842	Phage shock protein A
ORV05_22100	COG1396	sequence-specific DNA binding
ORV05_22105	COG1546	Belongs to the CinA family
ORV05_22105	COG1058	Belongs to the CinA family
ORV05_22115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ORV05_22120	COG0464	growth
ORV05_22125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ORV05_22145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ORV05_22150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ORV05_22155	COG0515	serine threonine protein kinase
ORV05_22185	COG3214	Protein conserved in bacteria
ORV05_22215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ORV05_22225	COG1185	polyribonucleotide nucleotidyltransferase activity
ORV05_22230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ORV05_22250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ORV05_22265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ORV05_22275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ORV05_22285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ORV05_22300	COG0779	Required for maturation of 30S ribosomal subunits
ORV05_22375	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_22385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_22395	COG0583	DNA-binding transcription factor activity
ORV05_22410	COG0583	DNA-binding transcription factor activity
ORV05_22420	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_22430	COG1120	ATPase activity
ORV05_22435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ORV05_22440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ORV05_22450	COG0646	methionine synthase
ORV05_22450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ORV05_22460	COG0582	viral genome integration into host DNA
ORV05_22500	COG1674	ftsk spoiiie
ORV05_22520	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ORV05_22525	COG1518	maintenance of DNA repeat elements
ORV05_22590	COG1309	transcriptional regulator
ORV05_22615	COG3384	dioxygenase
ORV05_22620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ORV05_22635	COG0583	DNA-binding transcription factor activity
ORV05_22650	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ORV05_22800	COG3321	synthase
ORV05_22800	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_22800	COG0604	alcohol dehydrogenase
ORV05_22810	COG2272	Belongs to the type-B carboxylesterase lipase family
ORV05_22815	COG4585	Histidine kinase
ORV05_22820	COG2197	response regulator
ORV05_22925	COG1595	DNA-templated transcription, initiation
ORV05_22995	COG1132	(ABC) transporter
ORV05_23005	COG0688	phosphatidylethanolamine metabolic process
ORV05_23025	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ORV05_23035	COG0791	NLP P60 protein
ORV05_23035	COG1388	LysM domain
ORV05_23055	COG0531	amino acid
ORV05_23060	COG0531	amino acid
ORV05_23070	COG1959	2 iron, 2 sulfur cluster binding
ORV05_23085	COG0346	lactoylglutathione lyase activity
ORV05_23090	COG0640	Transcriptional regulator
ORV05_23105	COG3511	phospholipase C
ORV05_23125	COG2197	response regulator
ORV05_23130	COG4585	Histidine kinase
ORV05_23150	COG4585	Histidine kinase
ORV05_23155	COG2197	response regulator
ORV05_23160	COG0860	N-Acetylmuramoyl-L-alanine amidase
ORV05_23170	COG0443	Heat shock 70 kDa protein
ORV05_23185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ORV05_23195	COG0443	Heat shock 70 kDa protein
ORV05_23225	COG0443	Heat shock 70 kDa protein
ORV05_23285	COG2124	cytochrome p450
ORV05_23290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_23295	COG1472	Belongs to the glycosyl hydrolase 3 family
ORV05_23300	COG1620	l-lactate permease
ORV05_23310	COG1506	peptidase
ORV05_23310	COG0823	Involved in the tonB-independent uptake of proteins
ORV05_23315	COG1309	transcriptional regulator
ORV05_23345	COG2909	trisaccharide binding
ORV05_23350	COG0489	protein tyrosine kinase activity
ORV05_23385	COG0745	RESPONSE REGULATOR receiver
ORV05_23390	COG5002	protein histidine kinase activity
ORV05_23400	COG0477	Major facilitator Superfamily
ORV05_23420	COG2301	Belongs to the HpcH HpaI aldolase family
ORV05_23425	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ORV05_23430	COG1960	acyl-CoA dehydrogenase activity
ORV05_23435	COG2188	Transcriptional regulator
ORV05_23475	COG0437	4 iron, 4 sulfur cluster binding
ORV05_23485	COG1024	Enoyl-CoA hydratase
ORV05_23515	COG1064	alcohol dehydrogenase
ORV05_23560	COG1140	nitrate reductase beta subunit
ORV05_23585	COG0640	Transcriptional regulator
ORV05_23600	COG1595	DNA-templated transcription, initiation
ORV05_23625	COG2197	response regulator
ORV05_23660	COG1316	TRANSCRIPTIONal
ORV05_23675	COG0515	serine threonine protein kinase
ORV05_23680	COG1132	(ABC) transporter
ORV05_23710	COG0582	viral genome integration into host DNA
ORV05_23725	COG4106	trans-aconitate 2-methyltransferase activity
ORV05_23740	COG1595	DNA-templated transcription, initiation
ORV05_23780	COG2197	response regulator
ORV05_23785	COG4585	Histidine kinase
ORV05_23795	COG1131	(ABC) transporter
ORV05_23800	COG1396	sequence-specific DNA binding
ORV05_23825	COG0423	glycine-tRNA ligase activity
ORV05_23845	COG0701	Predicted permease
ORV05_23855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ORV05_23860	COG1381	Involved in DNA repair and RecF pathway recombination
ORV05_23870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ORV05_23885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ORV05_23895	COG0537	adenosine 5'-monophosphoramidase activity
ORV05_23905	COG0484	heat shock protein binding
ORV05_23920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ORV05_23935	COG1953	Uracil, thiamine, allantoin
ORV05_23945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ORV05_23965	COG1136	(ABC) transporter
ORV05_23965	COG0577	efflux transmembrane transporter activity
ORV05_23970	COG1136	(ABC) transporter
ORV05_23970	COG0577	efflux transmembrane transporter activity
ORV05_23975	COG3842	ATPase activity
ORV05_23990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ORV05_23995	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ORV05_23995	COG3608	succinylglutamate desuccinylase aspartoacylase
ORV05_24070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ORV05_24080	COG1024	Enoyl-CoA hydratase
ORV05_24080	COG1250	3-hydroxyacyl-CoA dehydrogenase
ORV05_24085	COG2732	(Barnase) inhibitor
ORV05_24090	COG4290	ribonuclease
ORV05_24100	COG0604	alcohol dehydrogenase
ORV05_24110	COG0531	amino acid
ORV05_24115	COG2070	2-Nitropropane dioxygenase
ORV05_24120	COG0481	GTPase activity
ORV05_24125	COG2226	methyltransferase
ORV05_24155	COG0268	Binds directly to 16S ribosomal RNA
ORV05_24165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ORV05_24180	COG1307	EDD domain protein, DegV family
ORV05_24195	COG0799	negative regulation of ribosome biogenesis
ORV05_24200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ORV05_24210	COG0477	Major facilitator Superfamily
ORV05_24220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ORV05_24225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ORV05_24230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ORV05_24235	COG1530	ribonuclease E activity
ORV05_24235	COG1530	ribonuclease E activity
ORV05_24255	COG1131	(ABC) transporter
ORV05_24260	COG0105	UTP biosynthetic process
ORV05_24285	COG0285	dihydrofolate synthase activity
ORV05_24295	COG0154	amidase activity
ORV05_24300	COG1960	acyl-CoA dehydrogenase activity
ORV05_24315	COG2267	carboxylic ester hydrolase activity
ORV05_24320	COG0583	DNA-binding transcription factor activity
ORV05_24335	COG0477	Major facilitator Superfamily
ORV05_24365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ORV05_24380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ORV05_24385	COG0740	serine-type endopeptidase activity
ORV05_24390	COG0740	serine-type endopeptidase activity
ORV05_24395	COG0544	peptidyl-prolyl cis-trans isomerase activity
ORV05_24410	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ORV05_24440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ORV05_24445	COG2723	6-phospho-beta-galactosidase activity
ORV05_24450	COG0395	ABC-type sugar transport system, permease component
ORV05_24470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ORV05_24505	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_24520	COG2188	Transcriptional regulator
ORV05_24525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ORV05_24575	COG1846	Transcriptional regulator
ORV05_24620	COG2318	DinB family
ORV05_24635	COG0698	ribose 5-phosphate isomerase
ORV05_24650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ORV05_24660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ORV05_24675	COG0668	transmembrane transport
ORV05_24690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ORV05_24710	COG2902	Dehydrogenase
ORV05_24725	COG0629	single-stranded DNA binding
ORV05_24740	COG1609	Transcriptional regulator
ORV05_24750	COG3250	beta-galactosidase activity
ORV05_24760	COG3022	response to hydroperoxide
ORV05_24770	COG0513	Belongs to the DEAD box helicase family
ORV05_24775	COG0156	8-amino-7-oxononanoate synthase activity
ORV05_24800	COG2807	transmembrane transport
ORV05_24805	COG2186	Transcriptional regulator
ORV05_24825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ORV05_24830	COG0750	zinc metalloprotease
ORV05_24835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ORV05_24845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ORV05_24855	COG2226	methyltransferase
ORV05_24875	COG0528	UMP kinase activity
ORV05_24880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ORV05_24885	COG0052	Belongs to the universal ribosomal protein uS2 family
ORV05_24895	COG1191	sigma factor activity
ORV05_24915	COG0792	nuclease activity
ORV05_24925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ORV05_24930	COG0681	Belongs to the peptidase S26 family
ORV05_24935	COG0335	large ribosomal subunit rRNA binding
ORV05_24940	COG0336	Belongs to the RNA methyltransferase TrmD family
ORV05_24945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ORV05_24955	COG0228	four-way junction DNA binding
ORV05_24980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ORV05_24990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ORV05_25015	COG2873	o-acetylhomoserine
ORV05_25020	COG1832	CoA-binding protein
ORV05_25025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ORV05_25030	COG4266	Belongs to the allantoicase family
ORV05_25035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ORV05_25040	COG2084	Dehydrogenase
ORV05_25045	COG3622	Belongs to the hyi family
ORV05_25085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ORV05_25105	COG3835	regulator
ORV05_25120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ORV05_25125	COG1414	Transcriptional regulator
ORV05_25165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ORV05_25170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ORV05_25190	COG1254	Belongs to the acylphosphatase family
ORV05_25210	COG0367	asparagine synthase
ORV05_25220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ORV05_25225	COG0571	ribonuclease III activity
ORV05_25230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ORV05_25250	COG0742	ribosomal rna small subunit methyltransferase
ORV05_25255	COG3973	AAA domain
ORV05_25260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_25265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ORV05_25270	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ORV05_25280	COG1461	Dihydroxyacetone kinase
ORV05_25285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ORV05_25295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ORV05_25330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ORV05_25345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ORV05_25355	COG1920	GTP binding
ORV05_25360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ORV05_25375	COG0066	3-isopropylmalate dehydratase activity
ORV05_25380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ORV05_25395	COG1316	TRANSCRIPTIONal
ORV05_25430	COG0302	gtp cyclohydrolase
ORV05_25455	COG0215	cysteine-tRNA ligase activity
ORV05_25460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ORV05_25465	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_25480	COG3903	Transcriptional regulator
ORV05_25480	COG3629	intracellular signal transduction
ORV05_25515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ORV05_25520	COG2151	metal-sulfur cluster biosynthetic enzyme
ORV05_25525	COG3396	Phenylacetate-CoA oxygenase
ORV05_25530	COG3460	Phenylacetate-CoA oxygenase
ORV05_25535	COG3396	Phenylacetate-CoA oxygenase
ORV05_25540	COG2030	dehydratase
ORV05_25540	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_25555	COG1309	transcriptional regulator
ORV05_25570	COG3848	Pyruvate phosphate dikinase
ORV05_25570	COG0574	Belongs to the PEP-utilizing enzyme family
ORV05_25580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ORV05_25580	COG0574	Belongs to the PEP-utilizing enzyme family
ORV05_25605	COG2018	Roadblock/LC7 domain
ORV05_25635	COG0179	Fumarylacetoacetate (FAA) hydrolase
ORV05_25640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ORV05_25645	COG0473	3-isopropylmalate dehydrogenase activity
ORV05_25710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ORV05_25715	COG0440	acetolactate synthase activity
ORV05_25720	COG0028	Belongs to the TPP enzyme family
ORV05_25735	COG0154	amidase activity
ORV05_25750	COG0129	dihydroxy-acid dehydratase activity
ORV05_25790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ORV05_25800	COG0702	epimerase
ORV05_25805	COG2409	Drug exporters of the RND superfamily
ORV05_25820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ORV05_25840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_25850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ORV05_25855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ORV05_25860	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_25870	COG0482	sulfurtransferase activity
ORV05_25890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ORV05_25900	COG1307	EDD domain protein, DegV family
ORV05_25910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ORV05_25930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ORV05_25945	COG0431	NADPH-dependent FMN reductase
ORV05_25950	COG0110	maltose O-acetyltransferase activity
ORV05_25955	COG1957	nucleoside hydrolase
ORV05_25965	COG1846	Transcriptional regulator
ORV05_25970	COG0662	Cupin 2, conserved barrel domain protein
ORV05_25975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_25980	COG0402	S-adenosylhomocysteine deaminase activity
ORV05_25990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ORV05_26000	COG0277	FAD linked oxidase domain protein
ORV05_26050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ORV05_26055	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ORV05_26065	COG1234	tRNA 3'-trailer cleavage
ORV05_26070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ORV05_26085	COG2346	COG2346, Truncated hemoglobins
ORV05_26115	COG3191	aminopeptidase activity
ORV05_26125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ORV05_26130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ORV05_26135	COG1335	isochorismatase
ORV05_26170	COG3830	Belongs to the UPF0237 family
ORV05_26170	COG0560	Phosphoserine phosphatase
ORV05_26180	COG2267	carboxylic ester hydrolase activity
ORV05_26230	COG2376	Dihydroxyacetone kinase
ORV05_26245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ORV05_26275	COG1674	ftsk spoiiie
ORV05_26285	COG2188	Transcriptional regulator
ORV05_26350	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ORV05_26355	COG0494	nUDIX hydrolase
ORV05_26360	COG1024	Enoyl-CoA hydratase
ORV05_26365	COG1126	abc transporter atp-binding protein
ORV05_26370	COG0765	amino acid transport
ORV05_26375	COG0765	amino acid transport
ORV05_26385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ORV05_26385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ORV05_26390	COG1280	lysine exporter protein (LysE YggA)
ORV05_26415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ORV05_26420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ORV05_26425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ORV05_26430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ORV05_26435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ORV05_26440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ORV05_26445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ORV05_26450	COG0356	it plays a direct role in the translocation of protons across the membrane
ORV05_26460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ORV05_26470	COG2890	protein-(glutamine-N5) methyltransferase activity
ORV05_26480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ORV05_26485	COG0254	rRNA binding
ORV05_26500	COG0083	homoserine kinase activity
ORV05_26505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ORV05_26510	COG0460	homoserine dehydrogenase
ORV05_26515	COG0019	diaminopimelate decarboxylase activity
ORV05_26520	COG0018	arginyl-trna synthetase
ORV05_26545	COG1725	Transcriptional regulator
ORV05_26615	COG4552	Acetyltransferase involved in intracellular survival and related
ORV05_26630	COG1846	Transcriptional regulator
ORV05_26650	COG1846	Transcriptional regulator
ORV05_26655	COG0702	epimerase
ORV05_26705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ORV05_26710	COG1993	acr, cog1993
ORV05_26715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ORV05_26765	COG0366	Alpha amylase catalytic
ORV05_26770	COG0366	Alpha amylase catalytic
ORV05_26780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ORV05_26800	COG0515	serine threonine protein kinase
ORV05_26820	COG4336	lyase activity
ORV05_26840	COG0129	dihydroxy-acid dehydratase activity
ORV05_26845	COG1366	Belongs to the anti-sigma-factor antagonist family
ORV05_26855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ORV05_26860	COG0187	DNA topoisomerase II activity
ORV05_26865	COG0564	pseudouridine synthase activity
ORV05_26870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ORV05_26890	COG3285	dna ligase
ORV05_26890	COG1793	dna ligase
ORV05_26930	COG3260	NADH ubiquinone oxidoreductase 20
ORV05_26940	COG0650	Formate hydrogenlyase subunit 4
ORV05_26950	COG0651	ATP synthesis coupled electron transport
ORV05_26955	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ORV05_26955	COG3261	NADH dehydrogenase
ORV05_26970	COG2723	6-phospho-beta-galactosidase activity
ORV05_26975	COG0395	ABC-type sugar transport system, permease component
ORV05_26990	COG1609	Transcriptional regulator
ORV05_27010	COG0446	pyridine nucleotide-disulphide oxidoreductase
ORV05_27015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_27025	COG1846	Transcriptional regulator
ORV05_27030	COG0697	spore germination
ORV05_27075	COG3239	Fatty acid desaturase
ORV05_27080	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ORV05_27090	COG0714	Associated with various cellular activities
ORV05_27110	COG0674	pyruvate-flavodoxin oxidoreductase activity
ORV05_27115	COG1013	pyruvate-flavodoxin oxidoreductase activity
ORV05_27120	COG0493	'glutamate synthase
ORV05_27135	COG1595	DNA-templated transcription, initiation
ORV05_27170	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ORV05_27180	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_27210	COG0159	tryptophan synthase activity
ORV05_27215	COG0133	tryptophan synthase activity
ORV05_27245	COG0631	protein serine/threonine phosphatase activity
ORV05_27250	COG0515	serine threonine protein kinase
ORV05_27250	COG2815	serine threonine protein kinase
ORV05_27260	COG0443	Heat shock 70 kDa protein
ORV05_27270	COG2197	response regulator
ORV05_27300	COG1131	(ABC) transporter
ORV05_27305	COG1725	Transcriptional regulator
ORV05_27370	COG2367	Beta-lactamase
ORV05_27425	COG1309	transcriptional regulator
ORV05_27440	COG2188	Transcriptional regulator
ORV05_27455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ORV05_27460	COG0657	acetylesterase activity
ORV05_27465	COG2814	Major facilitator Superfamily
ORV05_27470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_27505	COG1181	Belongs to the D-alanine--D-alanine ligase family
ORV05_27510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ORV05_27520	COG0745	RESPONSE REGULATOR receiver
ORV05_27525	COG2205	protein histidine kinase activity
ORV05_27570	COG0596	Alpha beta hydrolase
ORV05_27590	COG4585	Histidine kinase
ORV05_27595	COG2197	response regulator
ORV05_27615	COG2318	DinB family
ORV05_27640	COG2963	transposase activity
ORV05_27645	COG2801	Transposase and inactivated derivatives
ORV05_27675	COG0405	Gamma-glutamyltransferase
ORV05_27695	COG1846	Transcriptional regulator
ORV05_27705	COG0778	Nitroreductase
ORV05_27710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ORV05_27715	COG0640	Transcriptional regulator
ORV05_27725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ORV05_27735	COG0798	PFAM Bile acid sodium symporter
ORV05_27770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ORV05_27795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ORV05_27815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ORV05_27820	COG1643	Atp-dependent helicase
ORV05_27850	COG2986	histidine ammonia-lyase
ORV05_27855	COG1414	Transcriptional regulator
ORV05_27870	COG4585	Histidine kinase
ORV05_27875	COG2197	response regulator
ORV05_27895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ORV05_27900	COG2177	Part of the ABC transporter FtsEX involved in
ORV05_27905	COG2884	Cell division ATP-binding protein ftsE
ORV05_27910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ORV05_27925	COG1615	UPF0182 protein
ORV05_27955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ORV05_28010	COG0174	glutamine synthetase
ORV05_28020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ORV05_28045	COG0174	glutamine synthetase
ORV05_28075	COG0653	protein targeting
ORV05_28080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ORV05_28080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ORV05_28100	COG2318	DinB family
ORV05_28105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ORV05_28110	COG1492	cobalamin metabolic process
ORV05_28115	COG2205	protein histidine kinase activity
ORV05_28125	COG2205	protein histidine kinase activity
ORV05_28130	COG0745	RESPONSE REGULATOR receiver
ORV05_28145	COG1017	nitric oxide dioxygenase activity
ORV05_28145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ORV05_28155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ORV05_28165	COG1968	undecaprenyl-diphosphatase activity
ORV05_28185	COG0557	exoribonuclease II activity
ORV05_28210	COG3883	PFAM NLP P60 protein
ORV05_28210	COG0791	NLP P60 protein
ORV05_28250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ORV05_28265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ORV05_28290	COG2186	Transcriptional regulator
ORV05_28295	COG3265	gluconokinase activity
ORV05_28315	COG0612	Peptidase, M16
ORV05_28355	COG0714	Associated with various cellular activities
ORV05_28385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ORV05_28390	COG0210	DNA helicase
ORV05_28395	COG0210	DNA helicase
ORV05_28410	COG2378	regulation of single-species biofilm formation
ORV05_28445	COG2146	nitrite reductase [NAD(P)H] activity
ORV05_28445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ORV05_28450	COG2223	nitrite transmembrane transporter activity
ORV05_28455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ORV05_28460	COG0243	molybdopterin cofactor binding
ORV05_28480	COG0596	Alpha beta hydrolase
ORV05_28490	COG2267	carboxylic ester hydrolase activity
ORV05_28520	COG0513	Belongs to the DEAD box helicase family
ORV05_28545	COG2095	MarC family integral membrane protein
ORV05_28550	COG0613	PHP domain protein
ORV05_28565	COG0406	alpha-ribazole phosphatase activity
ORV05_28565	COG0494	nUDIX hydrolase
ORV05_28585	COG0598	Magnesium transport protein CorA
ORV05_28605	COG1309	transcriptional regulator
ORV05_28640	COG0330	HflC and HflK could
ORV05_28645	COG2239	Acts as a magnesium transporter
ORV05_28670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ORV05_28675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ORV05_28685	COG1595	DNA-templated transcription, initiation
ORV05_28690	COG4122	O-methyltransferase activity
ORV05_28700	COG2814	Major facilitator Superfamily
ORV05_28705	COG0583	DNA-binding transcription factor activity
ORV05_28710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ORV05_28720	COG1024	Enoyl-CoA hydratase
ORV05_28725	COG2197	response regulator
ORV05_28740	COG2818	Glycosylase
ORV05_28765	COG1611	Belongs to the LOG family
ORV05_28770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ORV05_28810	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ORV05_28815	COG0778	Nitroreductase
ORV05_28815	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ORV05_28825	COG1725	Transcriptional regulator
ORV05_28835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ORV05_28870	COG0438	transferase activity, transferring glycosyl groups
ORV05_28885	COG0438	transferase activity, transferring glycosyl groups
ORV05_28900	COG1316	TRANSCRIPTIONal
ORV05_28905	COG1316	TRANSCRIPTIONal
ORV05_28930	COG1051	belongs to the nudix hydrolase family
ORV05_28970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ORV05_28980	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_29015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ORV05_29020	COG2205	protein histidine kinase activity
ORV05_29025	COG0745	RESPONSE REGULATOR receiver
ORV05_29030	COG0483	inositol monophosphate 1-phosphatase activity
ORV05_29070	COG3103	Sh3 type 3 domain protein
ORV05_29070	COG1388	LysM domain
ORV05_29070	COG0791	NLP P60 protein
ORV05_29100	COG3835	regulator
ORV05_29105	COG1309	transcriptional regulator
ORV05_29130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ORV05_29140	COG0515	serine threonine protein kinase
ORV05_29145	COG2271	Major facilitator Superfamily
ORV05_29150	COG2188	Transcriptional regulator
ORV05_29170	COG0424	maF-like protein
ORV05_29180	COG4770	biotin carboxylase activity
ORV05_29205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ORV05_29215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ORV05_29240	COG1473	amidohydrolase
ORV05_29240	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ORV05_29265	COG0515	serine threonine protein kinase
ORV05_29290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ORV05_29335	COG0667	Aldo Keto reductase
ORV05_29340	COG0789	Transcriptional regulator
ORV05_29360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ORV05_29365	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_29370	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_29385	COG2124	cytochrome p450
ORV05_29395	COG2124	cytochrome p450
ORV05_29420	COG2271	Major facilitator Superfamily
ORV05_29435	COG4585	Histidine kinase
ORV05_29440	COG2197	response regulator
ORV05_29445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ORV05_29465	COG1079	Belongs to the binding-protein-dependent transport system permease family
ORV05_29475	COG3845	ABC transporter
ORV05_29480	COG1744	ABC transporter substrate-binding protein PnrA-like
ORV05_29485	COG2009	succinate dehydrogenase
ORV05_29500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ORV05_29530	COG1686	Belongs to the peptidase S11 family
ORV05_29535	COG1295	ribonuclease BN
ORV05_29550	COG1136	(ABC) transporter
ORV05_29550	COG0577	efflux transmembrane transporter activity
ORV05_29555	COG1136	(ABC) transporter
ORV05_29565	COG0180	Tryptophanyl-tRNA synthetase
ORV05_29610	COG0708	Exodeoxyribonuclease III
ORV05_29635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_29660	COG2814	Major facilitator Superfamily
ORV05_29665	COG0640	Transcriptional regulator
ORV05_29670	COG2814	Major facilitator Superfamily
ORV05_29680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ORV05_29695	COG0587	DNA-directed DNA polymerase activity
ORV05_29715	COG0138	bifunctional purine biosynthesis protein purh
ORV05_29740	COG0045	succinate-CoA ligase (ADP-forming) activity
ORV05_29750	COG0739	heme binding
ORV05_29785	COG2815	serine threonine protein kinase
ORV05_29785	COG0515	serine threonine protein kinase
ORV05_29790	COG0515	serine threonine protein kinase
ORV05_29790	COG2815	serine threonine protein kinase
ORV05_29800	COG2910	NAD(P)H-binding
ORV05_29830	COG0519	Catalyzes the synthesis of GMP from XMP
ORV05_29830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ORV05_29835	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_29845	COG0516	GMP reductase activity
ORV05_29890	COG1309	transcriptional regulator
ORV05_29895	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_29900	COG0459	protein refolding
ORV05_29905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ORV05_29930	COG1733	regulation of RNA biosynthetic process
ORV05_29940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ORV05_29945	COG0456	acetyltransferase
ORV05_29955	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_29960	COG0825	malonyl-CoA metabolic process
ORV05_29960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ORV05_29965	COG0802	atpase or kinase
ORV05_29975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ORV05_29980	COG1070	Carbohydrate kinase
ORV05_29990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ORV05_30015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ORV05_30025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ORV05_30050	COG0443	Heat shock 70 kDa protein
ORV05_30055	COG1674	ftsk spoiiie
ORV05_30065	COG1404	Belongs to the peptidase S8 family
ORV05_30090	COG0101	tRNA pseudouridine synthase activity
ORV05_30095	COG0203	ribosomal protein L17
ORV05_30100	COG0202	RNA polymerase activity
ORV05_30105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ORV05_30110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ORV05_30120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ORV05_30125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ORV05_30130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ORV05_30140	COG0563	adenylate kinase activity
ORV05_30150	COG0200	Binds to the 23S rRNA
ORV05_30155	COG1841	ribosomal large subunit assembly
ORV05_30160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ORV05_30165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ORV05_30170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ORV05_30175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ORV05_30185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ORV05_30190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ORV05_30195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ORV05_30200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ORV05_30205	COG0255	Belongs to the universal ribosomal protein uL29 family
ORV05_30210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ORV05_30215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ORV05_30220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ORV05_30225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ORV05_30230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ORV05_30235	COG0089	rRNA binding
ORV05_30240	COG0088	Forms part of the polypeptide exit tunnel
ORV05_30245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ORV05_30250	COG0051	transcription antitermination factor activity, RNA binding
ORV05_30260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ORV05_30265	COG0049	tRNA binding
ORV05_30270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ORV05_30280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ORV05_30310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ORV05_30335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ORV05_30350	COG0222	ribosome binding
ORV05_30355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ORV05_30365	COG0081	regulation of translation
ORV05_30380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ORV05_30390	COG0436	Aminotransferase
ORV05_30405	COG2030	dehydratase
ORV05_30410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ORV05_30440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ORV05_30455	COG0667	Aldo Keto reductase
ORV05_30465	COG1793	dna ligase
ORV05_30505	COG1666	GTP binding
ORV05_30515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ORV05_30525	COG0596	Alpha beta hydrolase
ORV05_30535	COG0501	Belongs to the peptidase M48B family
ORV05_30540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_30545	COG1834	amidinotransferase
ORV05_30550	COG1522	sequence-specific DNA binding
ORV05_30560	COG0674	pyruvate-flavodoxin oxidoreductase activity
ORV05_30560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ORV05_30565	COG1013	pyruvate-flavodoxin oxidoreductase activity
ORV05_30575	COG0142	geranyltranstransferase activity
ORV05_30580	COG3547	Transposase (IS116 IS110 IS902 family)
ORV05_30585	COG1007	ATP synthesis coupled electron transport
ORV05_30600	COG0713	ATP synthesis coupled electron transport
ORV05_30605	COG0839	Belongs to the complex I subunit 6 family
ORV05_30610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ORV05_30615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ORV05_30620	COG1034	ATP synthesis coupled electron transport
ORV05_30635	COG0649	NAD binding
ORV05_30640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ORV05_30645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ORV05_30665	COG0438	transferase activity, transferring glycosyl groups
ORV05_30695	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ORV05_30715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ORV05_30725	COG1522	sequence-specific DNA binding
ORV05_30745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ORV05_30765	COG0406	alpha-ribazole phosphatase activity
ORV05_30770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ORV05_30795	COG1648	precorrin-2 dehydrogenase activity
ORV05_30795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ORV05_30800	COG0181	hydroxymethylbilane synthase activity
ORV05_30805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ORV05_30810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ORV05_30825	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_30830	COG1595	DNA-templated transcription, initiation
ORV05_30850	COG1309	transcriptional regulator
ORV05_30860	COG0488	(ABC) transporter
ORV05_30885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ORV05_30900	COG1082	Xylose isomerase domain protein TIM barrel
ORV05_30920	COG5002	protein histidine kinase activity
ORV05_30925	COG0667	Aldo Keto reductase
ORV05_30935	COG0588	phosphoglycerate mutase activity
ORV05_30945	COG0438	transferase activity, transferring glycosyl groups
ORV05_30960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ORV05_30995	COG0788	formyltetrahydrofolate deformylase activity
ORV05_31010	COG2130	NADP-dependent
ORV05_31025	COG1174	glycine betaine transport
ORV05_31055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ORV05_31070	COG1136	(ABC) transporter
ORV05_31090	COG2733	membrane
ORV05_31100	COG1595	DNA-templated transcription, initiation
ORV05_31110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ORV05_31115	COG2364	Membrane
ORV05_31155	COG1309	transcriptional regulator
ORV05_31240	COG1674	ftsk spoiiie
ORV05_31290	COG1473	amidohydrolase
ORV05_31295	COG0287	Prephenate dehydrogenase
ORV05_31360	COG1131	(ABC) transporter
ORV05_31365	COG3559	Exporter of polyketide antibiotics
ORV05_31375	COG1309	transcriptional regulator
ORV05_31395	COG2723	6-phospho-beta-galactosidase activity
ORV05_31405	COG0248	Ppx GppA phosphatase
ORV05_31410	COG0028	Belongs to the TPP enzyme family
ORV05_31420	COG0701	Predicted permease
ORV05_31435	COG1937	Protein conserved in bacteria
ORV05_31440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ORV05_31500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ORV05_31500	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ORV05_31505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ORV05_31515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ORV05_31540	COG1793	dna ligase
ORV05_31545	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ORV05_31565	COG1522	sequence-specific DNA binding
ORV05_31585	COG2197	response regulator
ORV05_31650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_31670	COG1733	regulation of RNA biosynthetic process
ORV05_31680	COG1733	regulation of RNA biosynthetic process
ORV05_31710	COG1063	alcohol dehydrogenase
ORV05_31735	COG1216	Glycosyl transferase, family 2
ORV05_31750	COG1216	Glycosyl transferase, family 2
ORV05_31760	COG0277	FAD linked oxidase domain protein
ORV05_31765	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_31785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ORV05_31800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ORV05_31805	COG0561	phosphatase activity
ORV05_31820	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_31840	COG2132	Multicopper oxidase
ORV05_31870	COG0579	oxidoreductase
ORV05_31875	COG0667	Aldo Keto reductase
ORV05_31895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ORV05_31900	COG0596	Alpha beta hydrolase
ORV05_31905	COG3766	membrane
ORV05_31910	COG0754	glutathionylspermidine amidase activity
ORV05_31940	COG0406	alpha-ribazole phosphatase activity
ORV05_31950	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ORV05_31955	COG1072	(Pantothenic acid kinase))
ORV05_32015	COG4988	ABC transporter
ORV05_32020	COG1294	oxidase, subunit
ORV05_32025	COG1271	oxidase subunit
ORV05_32070	COG2235	arginine
ORV05_32080	COG1191	sigma factor activity
ORV05_32110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ORV05_32120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ORV05_32130	COG3279	Response regulator of the LytR AlgR family
ORV05_32140	COG3275	phosphorelay sensor kinase activity
ORV05_32145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ORV05_32175	COG1126	abc transporter atp-binding protein
ORV05_32180	COG0765	amino acid transport
ORV05_32185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ORV05_32190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ORV05_32200	COG0022	dehydrogenase e1 component
ORV05_32205	COG0508	dehydrogenase complex catalyzes the overall conversion of
ORV05_32245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ORV05_32265	COG1216	Glycosyl transferase, family 2
ORV05_32265	COG0438	transferase activity, transferring glycosyl groups
ORV05_32280	COG2197	response regulator
ORV05_32285	COG4585	Histidine kinase
ORV05_32295	COG0477	Major facilitator Superfamily
ORV05_32310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ORV05_32335	COG1174	glycine betaine transport
ORV05_32345	COG1174	glycine betaine transport
ORV05_32390	COG2211	Major facilitator Superfamily
ORV05_32415	COG0702	epimerase
ORV05_32440	COG2301	Belongs to the HpcH HpaI aldolase family
ORV05_32445	COG2301	Belongs to the HpcH HpaI aldolase family
ORV05_32455	COG0154	amidase activity
ORV05_32460	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_32465	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_32470	COG4172	Belongs to the ABC transporter superfamily
ORV05_32475	COG0444	Belongs to the ABC transporter superfamily
ORV05_32480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ORV05_32490	COG0747	negative chemotaxis
ORV05_32515	COG0583	DNA-binding transcription factor activity
ORV05_32530	COG1716	ATPase activity
ORV05_32535	COG1716	ATPase activity
ORV05_32550	COG0768	penicillin binding
ORV05_32555	COG0515	serine threonine protein kinase
ORV05_32585	COG3764	Sortase (surface protein transpeptidase)
ORV05_32635	COG2318	DinB family
ORV05_32640	COG2814	Major facilitator Superfamily
ORV05_32650	COG4221	oxidoreductase activity
ORV05_32670	COG0655	NAD(P)H dehydrogenase (quinone) activity
ORV05_32810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ORV05_32815	COG0187	DNA topoisomerase II activity
ORV05_32820	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ORV05_32825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ORV05_32830	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ORV05_32835	COG0592	DNA-directed DNA polymerase activity
ORV05_32840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ORV05_32845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ORV05_32850	COG0594	ribonuclease P activity
ORV05_32855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ORV05_32870	COG0357	Ribosomal RNA small subunit methyltransferase G
ORV05_32875	COG1192	Involved in chromosome partitioning
ORV05_32885	COG1181	Belongs to the D-alanine--D-alanine ligase family
ORV05_32900	COG0860	N-Acetylmuramoyl-L-alanine amidase
ORV05_32900	COG3409	Peptidoglycan-binding domain 1 protein
ORV05_32920	COG1595	DNA-templated transcription, initiation
ORV05_32970	COG1678	Uncharacterized ACR, COG1678
ORV05_32980	COG0495	leucyl-tRNA aminoacylation
ORV05_32990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ORV05_32995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ORV05_33005	COG2197	response regulator
ORV05_33035	COG3384	dioxygenase
ORV05_33040	COG0640	Transcriptional regulator
ORV05_33075	COG0359	binds to the 23S rRNA
ORV05_33080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ORV05_33090	COG0360	Binds together with S18 to 16S ribosomal RNA
ORV05_33120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ORV05_33140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ORV05_33150	COG2814	Major facilitator Superfamily
ORV05_33165	COG0300	oxidoreductase activity
ORV05_33170	COG0402	S-adenosylhomocysteine deaminase activity
ORV05_33175	COG4221	oxidoreductase activity
ORV05_33185	COG2197	response regulator
ORV05_33195	COG1136	(ABC) transporter
ORV05_33205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ORV05_33230	COG2197	response regulator
ORV05_33235	COG4585	Histidine kinase
ORV05_33245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ORV05_33260	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ORV05_33315	COG0183	Belongs to the thiolase family
ORV05_33320	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_33325	COG2030	dehydratase
ORV05_33330	COG1309	transcriptional regulator
ORV05_33340	COG3030	protein affecting phage T7 exclusion by the F plasmid
ORV05_33370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ORV05_33385	COG1960	acyl-CoA dehydrogenase activity
ORV05_33390	COG2197	response regulator
ORV05_33415	COG4085	toxin activity
ORV05_33415	COG1525	nuclease
ORV05_33415	COG0737	Belongs to the 5'-nucleotidase family
ORV05_33430	COG0704	Plays a role in the regulation of phosphate uptake
ORV05_33435	COG2357	RelA SpoT domain protein
ORV05_33445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ORV05_33465	COG0456	acetyltransferase
ORV05_33465	COG0454	-acetyltransferase
ORV05_33470	COG0745	RESPONSE REGULATOR receiver
ORV05_33500	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ORV05_33505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ORV05_33510	COG1984	allophanate hydrolase subunit 2
ORV05_33520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ORV05_33545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ORV05_33550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ORV05_33610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ORV05_33615	COG1132	(ABC) transporter
ORV05_33625	COG0047	phosphoribosylformylglycinamidine synthase activity
ORV05_33630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ORV05_33640	COG1414	Transcriptional regulator
ORV05_33645	COG1376	ErfK ybiS ycfS ynhG family protein
ORV05_33650	COG1012	belongs to the aldehyde dehydrogenase family
ORV05_33665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ORV05_33695	COG0436	Aminotransferase
ORV05_33700	COG5280	Phage tail tape measure protein TP901
ORV05_33700	COG3953	SLT domain
ORV05_33730	COG0151	Belongs to the GarS family
ORV05_33740	COG0477	Major facilitator Superfamily
ORV05_33805	COG0667	Aldo Keto reductase
ORV05_33835	COG0586	Pfam SNARE associated Golgi protein
ORV05_33840	COG0277	FAD linked oxidase domain protein
ORV05_33845	COG3467	pyridoxamine 5'-phosphate
ORV05_33865	COG0586	Pfam SNARE associated Golgi protein
ORV05_33875	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_33880	COG1072	(Pantothenic acid kinase))
ORV05_33920	COG0243	molybdopterin cofactor binding
ORV05_33925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ORV05_33960	COG0300	oxidoreductase activity
ORV05_33970	COG0542	response to heat
ORV05_34000	COG1309	transcriptional regulator
ORV05_34005	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_34010	COG0412	Dienelactone hydrolase
ORV05_34015	COG0789	Transcriptional regulator
ORV05_34020	COG0484	heat shock protein binding
ORV05_34025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ORV05_34030	COG0443	Heat shock 70 kDa protein
ORV05_34045	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
ORV05_34055	COG2076	Multidrug Resistance protein
ORV05_34060	COG2181	nitrate reductase activity
ORV05_34060	COG0247	lactate metabolic process
ORV05_34085	COG1309	transcriptional regulator
ORV05_34090	COG1960	acyl-CoA dehydrogenase activity
ORV05_34100	COG0717	Belongs to the dCTP deaminase family
ORV05_34125	COG0789	Transcriptional regulator
ORV05_34165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ORV05_34220	COG1473	amidohydrolase
ORV05_34255	COG1960	acyl-CoA dehydrogenase activity
ORV05_34270	COG0183	Belongs to the thiolase family
ORV05_34280	COG0318	PFAM AMP-dependent synthetase and ligase
ORV05_34290	COG2814	Major facilitator Superfamily
ORV05_34300	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_34310	COG0596	Alpha beta hydrolase
ORV05_34330	COG0673	inositol 2-dehydrogenase activity
ORV05_34335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ORV05_34340	COG0726	polysaccharide deacetylase
ORV05_34365	COG0483	inositol monophosphate 1-phosphatase activity
ORV05_34380	COG2910	NAD(P)H-binding
ORV05_34385	COG1733	regulation of RNA biosynthetic process
ORV05_34390	COG0018	arginyl-trna synthetase
ORV05_34400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ORV05_34435	COG0667	Aldo Keto reductase
ORV05_34440	COG0640	Transcriptional regulator
ORV05_34445	COG2807	transmembrane transport
ORV05_34565	COG2814	Major facilitator Superfamily
ORV05_34595	COG0028	Belongs to the TPP enzyme family
ORV05_34620	COG0515	serine threonine protein kinase
ORV05_34645	COG1595	DNA-templated transcription, initiation
ORV05_34655	COG1278	Cold shock
ORV05_34730	COG2188	Transcriptional regulator
ORV05_34765	COG1609	Transcriptional regulator
ORV05_34790	COG1518	maintenance of DNA repeat elements
ORV05_34835	COG2197	response regulator
ORV05_34840	COG4585	Histidine kinase
ORV05_34895	COG2018	Roadblock/LC7 domain
ORV05_34930	COG5001	Diguanylate cyclase
ORV05_34930	COG3300	MHYT domain
ORV05_34945	COG0252	asparaginase activity
ORV05_34960	COG1902	pentaerythritol trinitrate reductase activity
ORV05_34975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ORV05_34980	COG1414	Transcriptional regulator
ORV05_34995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ORV05_35025	COG0745	RESPONSE REGULATOR receiver
ORV05_35030	COG2205	protein histidine kinase activity
ORV05_35040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ORV05_35055	COG0860	N-Acetylmuramoyl-L-alanine amidase
ORV05_35060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ORV05_35065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ORV05_35070	COG0529	Catalyzes the synthesis of activated sulfate
ORV05_35075	COG0747	negative chemotaxis
ORV05_35080	COG0601	transmembrane transport
ORV05_35085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ORV05_35090	COG0444	Belongs to the ABC transporter superfamily
ORV05_35095	COG4608	Belongs to the ABC transporter superfamily
ORV05_35105	COG0697	spore germination
ORV05_35110	COG0583	DNA-binding transcription factor activity
ORV05_35165	COG0657	acetylesterase activity
ORV05_35185	COG0076	glutamate decarboxylase activity
ORV05_35195	COG2226	methyltransferase
ORV05_35205	COG1408	metallophosphoesterase
ORV05_35210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ORV05_35255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ORV05_35260	COG0583	DNA-binding transcription factor activity
ORV05_35265	COG0300	oxidoreductase activity
ORV05_35300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ORV05_35315	COG0596	Alpha beta hydrolase
ORV05_35325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ORV05_35330	COG3104	oligopeptide transport
ORV05_35345	COG0477	Major facilitator Superfamily
ORV05_35370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ORV05_35375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ORV05_35385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ORV05_35390	COG1737	Transcriptional regulator
ORV05_35395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ORV05_35400	COG3876	Protein conserved in bacteria
ORV05_35405	COG1472	Belongs to the glycosyl hydrolase 3 family
ORV05_35455	COG1205	dead DEAH box helicase
ORV05_35455	COG1111	helicase
ORV05_35460	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ORV05_35475	COG1754	DNA topoisomerase type I activity
ORV05_35475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ORV05_35485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ORV05_35490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ORV05_35530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ORV05_35535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ORV05_35540	COG2027	D-alanyl-D-alanine carboxypeptidase
ORV05_35580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ORV05_35590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ORV05_35605	COG0789	Transcriptional regulator
ORV05_35630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ORV05_35635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ORV05_35640	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ORV05_35645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ORV05_35660	COG0542	response to heat
ORV05_35665	COG0443	Heat shock 70 kDa protein
ORV05_35700	COG0596	Alpha beta hydrolase
ORV05_35705	COG1194	a g-specific adenine glycosylase
ORV05_35710	COG1309	transcriptional regulator
ORV05_35715	COG2814	Major facilitator Superfamily
ORV05_35725	COG1609	Transcriptional regulator
ORV05_35735	COG1121	(ABC) transporter
ORV05_35745	COG4399	Belongs to the UPF0754 family
ORV05_35760	COG3548	integral membrane protein
ORV05_35765	COG0531	amino acid
ORV05_35810	COG0477	Major facilitator Superfamily
ORV05_35835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ORV05_35840	COG0215	cysteine-tRNA ligase activity
ORV05_35855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ORV05_35860	COG1329	Transcriptional regulator
ORV05_35865	COG2847	Copper chaperone PCu(A)C
ORV05_35870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ORV05_35910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ORV05_35915	COG1595	DNA-templated transcription, initiation
ORV05_35925	COG4941	Belongs to the sigma-70 factor family
ORV05_35930	COG3795	YCII-related domain
ORV05_35940	COG0513	Belongs to the DEAD box helicase family
ORV05_35945	COG1609	Transcriptional regulator
ORV05_35950	COG1129	ABC transporter
ORV05_35960	COG1172	Belongs to the binding-protein-dependent transport system permease family
ORV05_35980	COG3347	Dehydrogenase
ORV05_35980	COG1028	Short-chain dehydrogenase reductase Sdr
ORV05_35990	COG1070	Carbohydrate kinase
ORV05_35995	COG0247	lactate metabolic process
ORV05_36000	COG1139	Iron-sulfur cluster binding protein
ORV05_36005	COG1556	Lactate utilization protein
ORV05_36015	COG1131	(ABC) transporter
ORV05_36035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ORV05_36040	COG1832	CoA-binding protein
ORV05_36045	COG0709	Synthesizes selenophosphate from selenide and ATP
ORV05_36050	COG2197	response regulator
ORV05_36075	COG3276	selenocysteine insertion sequence binding
ORV05_36100	COG0596	Alpha beta hydrolase
ORV05_36130	COG0346	lactoylglutathione lyase activity
ORV05_36135	COG0400	carboxylic ester hydrolase activity
ORV05_36150	COG5416	Lipopolysaccharide assembly protein A domain
ORV05_36160	COG0456	acetyltransferase
ORV05_36170	COG1917	Cupin 2, conserved barrel domain protein
ORV05_36175	COG5285	phytanoyl-CoA dioxygenase
ORV05_36180	COG3629	intracellular signal transduction
ORV05_36180	COG3903	Transcriptional regulator
ORV05_36220	COG2971	BadF BadG BcrA BcrD
ORV05_36225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ORV05_36230	COG2188	Transcriptional regulator
ORV05_36235	COG0477	Major facilitator Superfamily
ORV05_36245	COG0352	thiamine-phosphate diphosphorylase activity
ORV05_36260	COG2022	thiamine diphosphate biosynthetic process
ORV05_36270	COG2205	protein histidine kinase activity
ORV05_36275	COG0745	RESPONSE REGULATOR receiver
ORV05_36295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ORV05_36305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ORV05_36310	COG0242	peptide deformylase activity
ORV05_36325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ORV05_36335	COG1309	transcriptional regulator