locus-tag	class	description
YIM_00015	COG0592	DNA-directed DNA polymerase activity
YIM_00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
YIM_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YIM_00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
YIM_00035	COG0187	DNA topoisomerase II activity
YIM_00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YIM_00145	COG3764	Sortase (surface protein transpeptidase)
YIM_00170	COG3795	YCII-related domain
YIM_00175	COG0515	serine threonine protein kinase
YIM_00175	COG2815	serine threonine protein kinase
YIM_00180	COG0515	serine threonine protein kinase
YIM_00185	COG0768	penicillin binding
YIM_00200	COG1716	ATPase activity
YIM_00205	COG1716	ATPase activity
YIM_00275	COG2186	Transcriptional regulator
YIM_00280	COG0747	negative chemotaxis
YIM_00300	COG4608	Belongs to the ABC transporter superfamily
YIM_00305	COG1012	belongs to the aldehyde dehydrogenase family
YIM_00310	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_00315	COG0154	amidase activity
YIM_00325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_00345	COG2301	Belongs to the HpcH HpaI aldolase family
YIM_00370	COG0702	epimerase
YIM_00445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YIM_00450	COG1174	glycine betaine transport
YIM_00460	COG1174	glycine betaine transport
YIM_00490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
YIM_00495	COG0697	spore germination
YIM_00535	COG0477	Major facilitator Superfamily
YIM_00545	COG4585	Histidine kinase
YIM_00550	COG2197	response regulator
YIM_00570	COG0438	transferase activity, transferring glycosyl groups
YIM_00615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YIM_00620	COG2234	aminopeptidase activity
YIM_00640	COG3397	chitin binding
YIM_00660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YIM_00665	COG3275	phosphorelay sensor kinase activity
YIM_00690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YIM_00695	COG3162	membrane
YIM_00700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YIM_00745	COG1191	sigma factor activity
YIM_00755	COG1528	Iron-storage protein
YIM_00760	COG2235	arginine
YIM_00785	COG0592	DNA-directed DNA polymerase activity
YIM_00840	COG1271	oxidase subunit
YIM_00845	COG1294	oxidase, subunit
YIM_00850	COG4988	ABC transporter
YIM_00860	COG1335	isochorismatase
YIM_00895	COG4715	Zinc finger, swim domain protein
YIM_00910	COG1072	(Pantothenic acid kinase))
YIM_00915	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YIM_00925	COG0406	alpha-ribazole phosphatase activity
YIM_00930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
YIM_00980	COG0754	glutathionylspermidine amidase activity
YIM_00985	COG3766	membrane
YIM_00990	COG0596	Alpha beta hydrolase
YIM_00995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
YIM_01010	COG0579	oxidoreductase
YIM_01070	COG0438	transferase activity, transferring glycosyl groups
YIM_01075	COG0110	maltose O-acetyltransferase activity
YIM_01100	COG0673	inositol 2-dehydrogenase activity
YIM_01105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YIM_01115	COG0546	phosphoglycolate phosphatase activity
YIM_01120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YIM_01125	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_01130	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_01170	COG0561	phosphatase activity
YIM_01175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_01190	COG0671	phosphoesterase, PA-phosphatase related
YIM_01195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
YIM_01225	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_01230	COG0277	FAD linked oxidase domain protein
YIM_01240	COG1216	Glycosyl transferase, family 2
YIM_01270	COG1216	Glycosyl transferase, family 2
YIM_01305	COG2234	aminopeptidase activity
YIM_01365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_01365	COG1672	PFAM Archaeal ATPase
YIM_01375	COG1960	acyl-CoA dehydrogenase activity
YIM_01390	COG2910	NAD(P)H-binding
YIM_01405	COG4585	Histidine kinase
YIM_01410	COG2197	response regulator
YIM_01415	COG2814	Major facilitator Superfamily
YIM_01425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YIM_01430	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_01430	COG2972	Histidine kinase
YIM_01440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
YIM_01450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
YIM_01470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YIM_01475	COG0412	Dienelactone hydrolase
YIM_01495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YIM_01605	COG0667	Aldo Keto reductase
YIM_01610	COG3647	Membrane
YIM_01645	COG4585	Histidine kinase
YIM_01650	COG2197	response regulator
YIM_01655	COG2183	response to ionizing radiation
YIM_01670	COG2080	2 iron, 2 sulfur cluster binding
YIM_01675	COG2010	Cytochrome c
YIM_01675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_01690	COG3559	Exporter of polyketide antibiotics
YIM_01695	COG1131	(ABC) transporter
YIM_01720	COG0287	Prephenate dehydrogenase
YIM_01785	COG1674	ftsk spoiiie
YIM_01810	COG2205	protein histidine kinase activity
YIM_01815	COG0745	RESPONSE REGULATOR receiver
YIM_01840	COG1739	Uncharacterized protein family UPF0029
YIM_01870	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
YIM_01910	COG2197	response regulator
YIM_01920	COG0745	RESPONSE REGULATOR receiver
YIM_01925	COG2205	protein histidine kinase activity
YIM_01930	COG3540	Alkaline phosphatase
YIM_01945	COG3467	pyridoxamine 5'-phosphate
YIM_01950	COG1733	regulation of RNA biosynthetic process
YIM_01955	COG0860	N-Acetylmuramoyl-L-alanine amidase
YIM_01960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YIM_01965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
YIM_01975	COG0747	negative chemotaxis
YIM_01990	COG0444	Belongs to the ABC transporter superfamily
YIM_01995	COG4608	Belongs to the ABC transporter superfamily
YIM_02000	COG0702	epimerase
YIM_02010	COG0583	DNA-binding transcription factor activity
YIM_02020	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_02070	COG1690	Belongs to the RtcB family
YIM_02105	COG1764	response to oxidative stress
YIM_02120	COG2226	methyltransferase
YIM_02135	COG1408	metallophosphoesterase
YIM_02140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YIM_02165	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
YIM_02220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YIM_02235	COG0596	Alpha beta hydrolase
YIM_02245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YIM_02250	COG3104	oligopeptide transport
YIM_02300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YIM_02310	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
YIM_02320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
YIM_02325	COG1737	Transcriptional regulator
YIM_02330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YIM_02335	COG3876	Protein conserved in bacteria
YIM_02340	COG1472	Belongs to the glycosyl hydrolase 3 family
YIM_02395	COG1205	dead DEAH box helicase
YIM_02395	COG1111	helicase
YIM_02400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
YIM_02425	COG1754	DNA topoisomerase type I activity
YIM_02425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YIM_02440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YIM_02475	COG1674	ftsk spoiiie
YIM_02525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_02540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YIM_02555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YIM_02565	COG0640	Transcriptional regulator
YIM_02580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YIM_02595	COG0037	tRNA processing
YIM_02625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YIM_02630	COG0302	gtp cyclohydrolase
YIM_02635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YIM_02650	COG0789	Transcriptional regulator
YIM_02675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YIM_02680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
YIM_02685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YIM_02705	COG0542	response to heat
YIM_02730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YIM_02745	COG0596	Alpha beta hydrolase
YIM_02755	COG1194	a g-specific adenine glycosylase
YIM_02765	COG1609	Transcriptional regulator
YIM_02775	COG1120	ATPase activity
YIM_02790	COG4399	Belongs to the UPF0754 family
YIM_02830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YIM_02845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
YIM_02850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YIM_02855	COG1329	Transcriptional regulator
YIM_02860	COG2847	Copper chaperone PCu(A)C
YIM_02865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
YIM_02900	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
YIM_02910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
YIM_02930	COG0384	phenazine biosynthesis protein PhzF
YIM_02935	COG0583	DNA-binding transcription factor activity
YIM_02940	COG1695	Transcriptional regulator
YIM_02945	COG1902	pentaerythritol trinitrate reductase activity
YIM_02945	COG0446	pyridine nucleotide-disulphide oxidoreductase
YIM_02965	COG2197	response regulator
YIM_02995	COG1832	CoA-binding protein
YIM_03030	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_03035	COG2124	cytochrome p450
YIM_03040	COG1012	belongs to the aldehyde dehydrogenase family
YIM_03040	COG2030	dehydratase
YIM_03045	COG3396	Phenylacetate-CoA oxygenase
YIM_03050	COG3460	Phenylacetate-CoA oxygenase
YIM_03055	COG3396	Phenylacetate-CoA oxygenase
YIM_03060	COG2151	metal-sulfur cluster biosynthetic enzyme
YIM_03065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YIM_03070	COG0477	Major facilitator Superfamily
YIM_03090	COG0129	dihydroxy-acid dehydratase activity
YIM_03125	COG0346	lactoylglutathione lyase activity
YIM_03130	COG0400	carboxylic ester hydrolase activity
YIM_03140	COG4399	Belongs to the UPF0754 family
YIM_03150	COG0456	acetyltransferase
YIM_03160	COG1917	Cupin 2, conserved barrel domain protein
YIM_03165	COG5285	phytanoyl-CoA dioxygenase
YIM_03170	COG3629	intracellular signal transduction
YIM_03170	COG3903	Transcriptional regulator
YIM_03190	COG2885	chlorophyll binding
YIM_03210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YIM_03220	COG2971	BadF BadG BcrA BcrD
YIM_03225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YIM_03230	COG2188	Transcriptional regulator
YIM_03235	COG0477	Major facilitator Superfamily
YIM_03250	COG0537	adenosine 5'-monophosphoramidase activity
YIM_03255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YIM_03275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YIM_03280	COG0352	thiamine-phosphate diphosphorylase activity
YIM_03285	COG2022	thiamine diphosphate biosynthetic process
YIM_03285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YIM_03295	COG2022	thiamine diphosphate biosynthetic process
YIM_03325	COG0351	phosphomethylpyrimidine kinase
YIM_03330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YIM_03345	COG0242	peptide deformylase activity
YIM_03365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YIM_03375	COG0688	phosphatidylethanolamine metabolic process
YIM_03395	COG1278	Cold shock
YIM_03405	COG0459	protein refolding
YIM_03420	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_03425	COG3629	intracellular signal transduction
YIM_03425	COG3903	Transcriptional regulator
YIM_03435	COG1414	Transcriptional regulator
YIM_03445	COG1061	Type III restriction enzyme res subunit
YIM_03465	COG3142	Participates in the control of copper homeostasis
YIM_03470	COG2814	Major facilitator Superfamily
YIM_03480	COG0765	amino acid transport
YIM_03495	COG2018	Roadblock/LC7 domain
YIM_03510	COG2018	Roadblock/LC7 domain
YIM_03545	COG1388	LysM domain
YIM_03560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YIM_03580	COG2175	clavaminate synthase activity
YIM_03595	COG3304	Inner membrane component domain
YIM_03600	COG0384	phenazine biosynthesis protein PhzF
YIM_03605	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_03610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YIM_03630	COG1278	Cold shock
YIM_03640	COG2814	Major facilitator Superfamily
YIM_03665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_03680	COG2252	PERMEase
YIM_03690	COG2814	Major facilitator Superfamily
YIM_03700	COG2162	N-hydroxyarylamine O-acetyltransferase activity
YIM_03710	COG5398	heme oxygenase
YIM_03725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YIM_03750	COG2205	protein histidine kinase activity
YIM_03755	COG0745	RESPONSE REGULATOR receiver
YIM_03770	COG1136	(ABC) transporter
YIM_03770	COG0577	efflux transmembrane transporter activity
YIM_03780	COG5650	phosphatidylinositol metabolic process
YIM_03795	COG2197	response regulator
YIM_03830	COG1309	transcriptional regulator
YIM_03840	COG0831	urea catabolic process
YIM_03845	COG0832	Belongs to the urease beta subunit family
YIM_03850	COG0804	urea catabolic process
YIM_03860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YIM_03865	COG0829	nickel cation binding
YIM_03885	COG0259	pyridoxamine-phosphate oxidase activity
YIM_03905	COG2017	converts alpha-aldose to the beta-anomer
YIM_03910	COG1228	amidohydrolase
YIM_03915	COG1960	acyl-CoA dehydrogenase activity
YIM_03925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YIM_03935	COG0415	Belongs to the DNA photolyase family
YIM_03940	COG1668	transmembrane transport
YIM_03945	COG4152	abc transporter atp-binding protein
YIM_03970	COG0277	FAD linked oxidase domain protein
YIM_04015	COG1169	isochorismate synthase
YIM_04040	COG1301	dicarboxylic acid transport
YIM_04045	COG1960	acyl-CoA dehydrogenase activity
YIM_04065	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_04070	COG1024	Enoyl-CoA hydratase
YIM_04085	COG1321	iron dependent repressor
YIM_04095	COG1113	amino acid transport
YIM_04120	COG2409	Drug exporters of the RND superfamily
YIM_04125	COG2205	protein histidine kinase activity
YIM_04130	COG0745	RESPONSE REGULATOR receiver
YIM_04140	COG4221	oxidoreductase activity
YIM_04150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_04170	COG1335	isochorismatase
YIM_04210	COG0596	Alpha beta hydrolase
YIM_04225	COG2205	protein histidine kinase activity
YIM_04230	COG0745	RESPONSE REGULATOR receiver
YIM_04245	COG1136	(ABC) transporter
YIM_04250	COG0577	efflux transmembrane transporter activity
YIM_04250	COG1136	(ABC) transporter
YIM_04290	COG0596	Alpha beta hydrolase
YIM_04335	COG2197	response regulator
YIM_04340	COG2860	membrane
YIM_04355	COG1349	DNA-binding transcription factor activity
YIM_04365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YIM_04400	COG0745	RESPONSE REGULATOR receiver
YIM_04405	COG5002	protein histidine kinase activity
YIM_04415	COG0521	Mo-molybdopterin cofactor biosynthetic process
YIM_04415	COG0315	cyclic pyranopterin monophosphate synthase activity
YIM_04425	COG1970	mechanosensitive ion channel activity
YIM_04440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YIM_04445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YIM_04485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YIM_04510	COG2910	NAD(P)H-binding
YIM_04515	COG1309	transcriptional regulator
YIM_04525	COG4585	Histidine kinase
YIM_04530	COG2197	response regulator
YIM_04535	COG2409	Drug exporters of the RND superfamily
YIM_04560	COG1012	belongs to the aldehyde dehydrogenase family
YIM_04570	COG2258	MOSC domain
YIM_04655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YIM_04660	COG0084	hydrolase, TatD family'
YIM_04665	COG3583	domain protein
YIM_04675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
YIM_04680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
YIM_04685	COG0488	(ABC) transporter
YIM_04690	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_04705	COG0193	aminoacyl-tRNA hydrolase activity
YIM_04720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_04730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
YIM_04735	COG0745	RESPONSE REGULATOR receiver
YIM_04735	COG3706	GGDEF domain
YIM_04750	COG1309	transcriptional regulator
YIM_04765	COG2133	pyrroloquinoline quinone binding
YIM_04800	COG3634	alkyl hydroperoxide reductase activity
YIM_04820	COG0148	phosphopyruvate hydratase activity
YIM_04850	COG0747	negative chemotaxis
YIM_04855	COG0601	transmembrane transport
YIM_04865	COG0444	Belongs to the ABC transporter superfamily
YIM_04870	COG4608	Belongs to the ABC transporter superfamily
YIM_04875	COG1404	Belongs to the peptidase S8 family
YIM_04910	COG1252	NADH dehydrogenase
YIM_04925	COG2197	response regulator
YIM_04930	COG4585	Histidine kinase
YIM_04940	COG1733	regulation of RNA biosynthetic process
YIM_04965	COG1953	Uracil, thiamine, allantoin
YIM_04970	COG1802	Transcriptional regulator
YIM_04980	COG0789	Transcriptional regulator
YIM_04985	COG1902	pentaerythritol trinitrate reductase activity
YIM_05005	COG2391	methyltransferase activity
YIM_05010	COG0183	Belongs to the thiolase family
YIM_05050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YIM_05055	COG3185	4-Hydroxyphenylpyruvate dioxygenase
YIM_05065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YIM_05070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YIM_05080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YIM_05090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YIM_05100	COG1331	Highly conserved protein containing a thioredoxin domain
YIM_05120	COG0789	Transcriptional regulator
YIM_05145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
YIM_05195	COG1793	dna ligase
YIM_05200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YIM_05205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_05215	COG0667	Aldo Keto reductase
YIM_05235	COG0114	fumarate hydratase activity
YIM_05240	COG0492	ferredoxin-NADP+ reductase activity
YIM_05255	COG1722	exodeoxyribonuclease VII activity
YIM_05265	COG1570	exodeoxyribonuclease VII activity
YIM_05275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
YIM_05280	COG0667	Aldo Keto reductase
YIM_05295	COG0420	3'-5' exonuclease activity
YIM_05300	COG0419	ATPase involved in DNA repair
YIM_05310	COG0012	GTP binding
YIM_05330	COG2154	pterin-4-alpha-carbinolamine dehydratase
YIM_05345	COG3842	ATPase activity
YIM_05355	COG1131	(ABC) transporter
YIM_05365	COG0745	RESPONSE REGULATOR receiver
YIM_05375	COG0494	nUDIX hydrolase
YIM_05380	COG0180	Tryptophanyl-tRNA synthetase
YIM_05400	COG0747	negative chemotaxis
YIM_05430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YIM_05445	COG1994	Peptidase M50
YIM_05475	COG2835	tetraacyldisaccharide 4'-kinase activity
YIM_05485	COG1482	cell wall glycoprotein biosynthetic process
YIM_05510	COG0531	amino acid
YIM_05520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
YIM_05530	COG1414	Transcriptional regulator
YIM_05535	COG0745	RESPONSE REGULATOR receiver
YIM_05540	COG5002	protein histidine kinase activity
YIM_05545	COG5401	PFAM Sporulation and spore germination
YIM_05555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YIM_05560	COG0653	protein targeting
YIM_05580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YIM_05595	COG1012	belongs to the aldehyde dehydrogenase family
YIM_05610	COG2135	peptidase activity
YIM_05620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YIM_05625	COG1595	DNA-templated transcription, initiation
YIM_05635	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
YIM_05650	COG1597	lipid kinase activity
YIM_05665	COG0406	alpha-ribazole phosphatase activity
YIM_05680	COG0281	malic enzyme
YIM_05690	COG1125	glycine betaine transport
YIM_05690	COG0517	IMP dehydrogenase activity
YIM_05695	COG1174	glycine betaine transport
YIM_05700	COG1174	glycine betaine transport
YIM_05710	COG3153	acetyltransferase
YIM_05720	COG0508	dehydrogenase complex catalyzes the overall conversion of
YIM_05720	COG0567	Dehydrogenase, E1 component
YIM_05760	COG1132	(ABC) transporter
YIM_05775	COG0477	Major facilitator Superfamily
YIM_05785	COG0686	Belongs to the AlaDH PNT family
YIM_05805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
YIM_05805	COG2508	Transcriptional regulator
YIM_05820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YIM_05850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YIM_05860	COG1960	acyl-CoA dehydrogenase activity
YIM_05870	COG4221	oxidoreductase activity
YIM_05885	COG1434	Gram-negative-bacterium-type cell wall biogenesis
YIM_05900	COG1960	acyl-CoA dehydrogenase activity
YIM_05910	COG1309	transcriptional regulator
YIM_05915	COG0183	Belongs to the thiolase family
YIM_05920	COG1024	Enoyl-CoA hydratase
YIM_05920	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_05950	COG0028	Belongs to the TPP enzyme family
YIM_05980	COG0473	3-isopropylmalate dehydrogenase activity
YIM_05985	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YIM_05990	COG2186	Transcriptional regulator
YIM_06010	COG0154	amidase activity
YIM_06025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YIM_06040	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
YIM_06055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YIM_06075	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_06095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_06130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
YIM_06140	COG0640	Transcriptional regulator
YIM_06145	COG2267	carboxylic ester hydrolase activity
YIM_06165	COG1129	ABC transporter
YIM_06170	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_06185	COG4952	isomerase
YIM_06200	COG1879	ABC-type sugar transport system periplasmic component
YIM_06205	COG1129	ABC transporter
YIM_06210	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_06215	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_06230	COG1280	lysine exporter protein (LysE YggA)
YIM_06235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YIM_06235	COG0072	phenylalanine-tRNA ligase activity
YIM_06245	COG4941	Belongs to the sigma-70 factor family
YIM_06250	COG0129	dihydroxy-acid dehydratase activity
YIM_06270	COG0018	arginyl-trna synthetase
YIM_06275	COG0019	diaminopimelate decarboxylase activity
YIM_06285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
YIM_06290	COG0083	homoserine kinase activity
YIM_06295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YIM_06305	COG0254	rRNA binding
YIM_06310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
YIM_06320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_06330	COG0789	Transcriptional regulator
YIM_06335	COG2890	protein-(glutamine-N5) methyltransferase activity
YIM_06345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YIM_06370	COG0356	it plays a direct role in the translocation of protons across the membrane
YIM_06375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
YIM_06380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
YIM_06385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
YIM_06395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
YIM_06400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
YIM_06405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
YIM_06435	COG1280	lysine exporter protein (LysE YggA)
YIM_06445	COG1674	ftsk spoiiie
YIM_06450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YIM_06465	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
YIM_06485	COG2376	Dihydroxyacetone kinase
YIM_06490	COG1461	Dihydroxyacetone kinase
YIM_06495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YIM_06495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YIM_06505	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_06525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YIM_06530	COG2207	Transcriptional regulator
YIM_06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YIM_06550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YIM_06550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_06570	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_06570	COG1672	PFAM Archaeal ATPase
YIM_06580	COG0653	protein targeting
YIM_06610	COG0174	glutamine synthetase
YIM_06645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
YIM_06705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YIM_06725	COG3480	Lon protease (S16) C-terminal proteolytic domain
YIM_06735	COG1615	UPF0182 protein
YIM_06745	COG2378	regulation of single-species biofilm formation
YIM_06765	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
YIM_06770	COG2884	Cell division ATP-binding protein ftsE
YIM_06775	COG2177	Part of the ABC transporter FtsEX involved in
YIM_06780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
YIM_06800	COG1846	Transcriptional regulator
YIM_06810	COG2197	response regulator
YIM_06815	COG4585	Histidine kinase
YIM_06860	COG1937	Protein conserved in bacteria
YIM_06885	COG2986	histidine ammonia-lyase
YIM_06890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
YIM_06905	COG1228	amidohydrolase
YIM_06925	COG1819	glycosyl
YIM_06930	COG4585	Histidine kinase
YIM_06955	COG0671	phosphoesterase, PA-phosphatase related
YIM_06970	COG1643	Atp-dependent helicase
YIM_06975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_06990	COG3883	PFAM NLP P60 protein
YIM_06990	COG0791	NLP P60 protein
YIM_07025	COG1819	glycosyl
YIM_07030	COG3903	Transcriptional regulator
YIM_07030	COG3629	intracellular signal transduction
YIM_07075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_07075	COG3153	acetyltransferase
YIM_07080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_07110	COG1366	Belongs to the anti-sigma-factor antagonist family
YIM_07115	COG1366	Belongs to the anti-sigma-factor antagonist family
YIM_07120	COG2172	sigma factor antagonist activity
YIM_07245	COG1309	transcriptional regulator
YIM_07265	COG2267	carboxylic ester hydrolase activity
YIM_07345	COG0667	Aldo Keto reductase
YIM_07405	COG1011	Hydrolase
YIM_07475	COG3706	GGDEF domain
YIM_07585	COG0714	Associated with various cellular activities
YIM_07685	COG4974	Belongs to the 'phage' integrase family
YIM_07710	COG1388	LysM domain
YIM_07710	COG0791	NLP P60 protein
YIM_07710	COG3103	Sh3 type 3 domain protein
YIM_07770	COG0270	DNA (cytosine-5-)-methyltransferase activity
YIM_07860	COG3629	intracellular signal transduction
YIM_07860	COG3903	Transcriptional regulator
YIM_07885	COG0583	DNA-binding transcription factor activity
YIM_07890	COG0076	glutamate decarboxylase activity
YIM_07895	COG2197	response regulator
YIM_07900	COG1162	GTPase activity
YIM_07935	COG1053	succinate dehydrogenase
YIM_08010	COG0738	Major facilitator superfamily
YIM_08025	COG0789	Transcriptional regulator
YIM_08030	COG2362	D-Aminopeptidase
YIM_08045	COG1733	regulation of RNA biosynthetic process
YIM_08055	COG2311	Membrane
YIM_08060	COG4585	Histidine kinase
YIM_08065	COG2197	response regulator
YIM_08075	COG1063	alcohol dehydrogenase
YIM_08080	COG2318	DinB family
YIM_08110	COG0596	Alpha beta hydrolase
YIM_08170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YIM_08210	COG2226	methyltransferase
YIM_08230	COG3226	Transcriptional regulator
YIM_08235	COG3629	intracellular signal transduction
YIM_08235	COG3903	Transcriptional regulator
YIM_08240	COG2610	gluconate transmembrane transporter activity
YIM_08255	COG0583	DNA-binding transcription factor activity
YIM_08275	COG1309	transcriptional regulator
YIM_08280	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_08285	COG4977	sequence-specific DNA binding
YIM_08310	COG2205	protein histidine kinase activity
YIM_08315	COG0745	RESPONSE REGULATOR receiver
YIM_08330	COG1131	(ABC) transporter
YIM_08345	COG0017	Asparaginyl-tRNA synthetase
YIM_08365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
YIM_08420	COG1316	TRANSCRIPTIONal
YIM_08435	COG3903	Transcriptional regulator
YIM_08435	COG3629	intracellular signal transduction
YIM_08440	COG3706	GGDEF domain
YIM_08440	COG0745	RESPONSE REGULATOR receiver
YIM_08450	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_08460	COG1309	transcriptional regulator
YIM_08480	COG1116	anion transmembrane transporter activity
YIM_08485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YIM_08500	COG2018	Roadblock/LC7 domain
YIM_08515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YIM_08520	COG1595	DNA-templated transcription, initiation
YIM_08525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YIM_08565	COG2205	protein histidine kinase activity
YIM_08570	COG2018	Roadblock/LC7 domain
YIM_08610	COG0387	Pfam Sodium calcium exchanger
YIM_08615	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_08620	COG0385	Bile acid
YIM_08630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YIM_08635	COG1846	Transcriptional regulator
YIM_08640	COG0446	pyridine nucleotide-disulphide oxidoreductase
YIM_08650	COG1121	(ABC) transporter
YIM_08705	COG0531	amino acid
YIM_08715	COG2197	response regulator
YIM_08720	COG3903	Transcriptional regulator
YIM_08720	COG3629	intracellular signal transduction
YIM_08745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YIM_08750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
YIM_08760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YIM_08780	COG0297	glycogen (starch) synthase activity
YIM_08790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YIM_08795	COG0483	inositol monophosphate 1-phosphatase activity
YIM_08825	COG1846	Transcriptional regulator
YIM_08830	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_08895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
YIM_08930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YIM_08935	COG0433	COG0433 Predicted ATPase
YIM_08950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YIM_08960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YIM_08965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YIM_08970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YIM_08980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
YIM_08990	COG1418	mRNA catabolic process
YIM_09005	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_09040	COG0183	Belongs to the thiolase family
YIM_09060	COG1309	transcriptional regulator
YIM_09065	COG0300	oxidoreductase activity
YIM_09070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_09075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_09080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
YIM_09090	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_09105	COG1609	Transcriptional regulator
YIM_09110	COG2409	Drug exporters of the RND superfamily
YIM_09115	COG1846	Transcriptional regulator
YIM_09140	COG0058	SHG alpha-glucan phosphorylase activity
YIM_09165	COG1119	ATPase activity
YIM_09185	COG2197	response regulator
YIM_09190	COG4585	Histidine kinase
YIM_09215	COG4195	phage-related replication protein
YIM_09225	COG0789	Transcriptional regulator
YIM_09230	COG0346	lactoylglutathione lyase activity
YIM_09260	COG2267	carboxylic ester hydrolase activity
YIM_09265	COG0110	maltose O-acetyltransferase activity
YIM_09275	COG0640	Transcriptional regulator
YIM_09285	COG2814	Major facilitator Superfamily
YIM_09310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YIM_09330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_09370	COG4221	oxidoreductase activity
YIM_09380	COG0446	pyridine nucleotide-disulphide oxidoreductase
YIM_09380	COG1902	pentaerythritol trinitrate reductase activity
YIM_09385	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_09390	COG0791	NLP P60 protein
YIM_09390	COG1388	LysM domain
YIM_09390	COG3103	Sh3 type 3 domain protein
YIM_09400	COG0110	maltose O-acetyltransferase activity
YIM_09470	COG0386	Belongs to the glutathione peroxidase family
YIM_09480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YIM_09495	COG1307	EDD domain protein, DegV family
YIM_09505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
YIM_09520	COG0477	Major facilitator Superfamily
YIM_09530	COG0482	sulfurtransferase activity
YIM_09545	COG3386	PFAM SMP-30 Gluconolaconase
YIM_09550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YIM_09560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YIM_09560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_09575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YIM_09580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_09590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YIM_09595	COG0154	amidase activity
YIM_09605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YIM_09635	COG0129	dihydroxy-acid dehydratase activity
YIM_09650	COG0440	acetolactate synthase activity
YIM_09655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YIM_09695	COG1404	Belongs to the peptidase S8 family
YIM_09700	COG0473	3-isopropylmalate dehydrogenase activity
YIM_09705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YIM_09710	COG0179	Fumarylacetoacetate (FAA) hydrolase
YIM_09720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YIM_09755	COG1309	transcriptional regulator
YIM_09775	COG0463	Glycosyl transferase, family 2
YIM_09790	COG0640	Transcriptional regulator
YIM_09795	COG0492	ferredoxin-NADP+ reductase activity
YIM_09805	COG2072	flavoprotein involved in K transport
YIM_09840	COG0346	lactoylglutathione lyase activity
YIM_09850	COG0640	Transcriptional regulator
YIM_09885	COG1131	(ABC) transporter
YIM_09925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_09940	COG4221	oxidoreductase activity
YIM_09950	COG2132	Multicopper oxidase
YIM_10010	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
YIM_10080	COG2409	Drug exporters of the RND superfamily
YIM_10115	COG2205	protein histidine kinase activity
YIM_10125	COG0183	Belongs to the thiolase family
YIM_10135	COG2030	dehydratase
YIM_10140	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_10150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YIM_10155	COG0066	3-isopropylmalate dehydratase activity
YIM_10165	COG3629	intracellular signal transduction
YIM_10165	COG3903	Transcriptional regulator
YIM_10190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
YIM_10205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_10210	COG1181	Belongs to the D-alanine--D-alanine ligase family
YIM_10240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YIM_10245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YIM_10250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YIM_10255	COG1461	Dihydroxyacetone kinase
YIM_10275	COG4191	Histidine kinase
YIM_10290	COG3293	Transposase
YIM_10305	COG4336	lyase activity
YIM_10310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YIM_10315	COG1984	allophanate hydrolase subunit 2
YIM_10355	COG1929	Belongs to the glycerate kinase type-1 family
YIM_10370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
YIM_10375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
YIM_10385	COG3485	protocatechuate 3,4-dioxygenase
YIM_10390	COG3485	protocatechuate 3,4-dioxygenase
YIM_10395	COG0596	Alpha beta hydrolase
YIM_10400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_10405	COG1414	Transcriptional regulator
YIM_10410	COG0746	molybdenum cofactor guanylyltransferase activity
YIM_10415	COG1349	DNA-binding transcription factor activity
YIM_10420	COG1105	Belongs to the carbohydrate kinase PfkB family
YIM_10430	COG2213	PTS system mannitol-specific
YIM_10430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YIM_10435	COG2213	PTS system mannitol-specific
YIM_10435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YIM_10440	COG1063	alcohol dehydrogenase
YIM_10445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YIM_10450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YIM_10455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YIM_10495	COG3795	YCII-related domain
YIM_10500	COG5650	phosphatidylinositol metabolic process
YIM_10505	COG3962	Belongs to the TPP enzyme family
YIM_10510	COG3718	enzyme involved in inositol metabolism
YIM_10520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YIM_10540	COG1082	Xylose isomerase domain protein TIM barrel
YIM_10545	COG1609	Transcriptional regulator
YIM_10550	COG0673	inositol 2-dehydrogenase activity
YIM_10565	COG0531	amino acid
YIM_10575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
YIM_10580	COG1012	belongs to the aldehyde dehydrogenase family
YIM_10590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YIM_10590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YIM_10595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YIM_10600	COG0509	glycine decarboxylation via glycine cleavage system
YIM_10605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YIM_10610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YIM_10615	COG1760	l-serine dehydratase
YIM_10620	COG2186	Transcriptional regulator
YIM_10625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YIM_10635	COG1120	ATPase activity
YIM_10640	COG4221	oxidoreductase activity
YIM_10660	COG2910	NAD(P)H-binding
YIM_10665	COG2814	Major facilitator Superfamily
YIM_10675	COG0475	glutathione-regulated potassium exporter activity
YIM_10690	COG1643	Atp-dependent helicase
YIM_10715	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_10755	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_10765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YIM_10775	COG1116	anion transmembrane transporter activity
YIM_10775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YIM_10780	COG0673	inositol 2-dehydrogenase activity
YIM_10825	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_10845	COG0542	response to heat
YIM_10855	COG1228	amidohydrolase
YIM_10870	COG3275	phosphorelay sensor kinase activity
YIM_10875	COG3279	Response regulator of the LytR AlgR family
YIM_10885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YIM_10895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YIM_10900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YIM_10950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YIM_10995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_11000	COG3973	AAA domain
YIM_11005	COG0742	ribosomal rna small subunit methyltransferase
YIM_11010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
YIM_11030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YIM_11035	COG0571	ribonuclease III activity
YIM_11040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YIM_11060	COG1940	carbohydrate kinase activity
YIM_11065	COG0367	asparagine synthase
YIM_11080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
YIM_11090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
YIM_11110	COG1254	Belongs to the acylphosphatase family
YIM_11145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YIM_11150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
YIM_11160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YIM_11165	COG1414	Transcriptional regulator
YIM_11180	COG1301	dicarboxylic acid transport
YIM_11185	COG3835	regulator
YIM_11205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_11215	COG1309	transcriptional regulator
YIM_11220	COG2233	PERMEase
YIM_11250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YIM_11255	COG1832	CoA-binding protein
YIM_11265	COG0667	Aldo Keto reductase
YIM_11295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
YIM_11305	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
YIM_11330	COG0228	four-way junction DNA binding
YIM_11345	COG0336	Belongs to the RNA methyltransferase TrmD family
YIM_11350	COG0335	large ribosomal subunit rRNA binding
YIM_11355	COG0681	Belongs to the peptidase S26 family
YIM_11360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
YIM_11370	COG0792	nuclease activity
YIM_11380	COG0606	chelatase, subunit chli
YIM_11395	COG1191	sigma factor activity
YIM_11405	COG0052	Belongs to the universal ribosomal protein uS2 family
YIM_11410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YIM_11415	COG0528	UMP kinase activity
YIM_11420	COG0233	cytoplasmic translational termination
YIM_11440	COG1695	Transcriptional regulator
YIM_11445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
YIM_11475	COG0477	Major facilitator Superfamily
YIM_11490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_11495	COG0019	diaminopimelate decarboxylase activity
YIM_11600	COG3321	synthase
YIM_11600	COG0604	alcohol dehydrogenase
YIM_11610	COG2267	carboxylic ester hydrolase activity
YIM_11655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YIM_11710	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
YIM_11735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
YIM_11740	COG0750	zinc metalloprotease
YIM_11745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
YIM_11760	COG0456	acetyltransferase
YIM_11760	COG0454	-acetyltransferase
YIM_11780	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_11795	COG2186	Transcriptional regulator
YIM_11800	COG2807	transmembrane transport
YIM_11835	COG0513	Belongs to the DEAD box helicase family
YIM_11850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YIM_11855	COG3022	response to hydroperoxide
YIM_11860	COG0456	acetyltransferase
YIM_11865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YIM_11875	COG0442	prolyl-tRNA aminoacylation
YIM_11895	COG0432	Pfam Uncharacterised protein family UPF0047
YIM_11900	COG2197	response regulator
YIM_11930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YIM_11935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YIM_11940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YIM_11975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YIM_12010	COG0668	transmembrane transport
YIM_12015	COG3201	nicotinamide mononucleotide transporter
YIM_12020	COG1620	l-lactate permease
YIM_12030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YIM_12070	COG0596	Alpha beta hydrolase
YIM_12085	COG2267	carboxylic ester hydrolase activity
YIM_12115	COG1113	amino acid transport
YIM_12125	COG0587	DNA-directed DNA polymerase activity
YIM_12160	COG0586	Pfam SNARE associated Golgi protein
YIM_12165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YIM_12190	COG0321	lipoyl(octanoyl) transferase activity
YIM_12215	COG0508	dehydrogenase complex catalyzes the overall conversion of
YIM_12220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YIM_12235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YIM_12255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YIM_12260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
YIM_12265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YIM_12270	COG0667	Aldo Keto reductase
YIM_12300	COG1414	Transcriptional regulator
YIM_12310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YIM_12325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YIM_12335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YIM_12345	COG1845	cytochrome c oxidase, subunit III
YIM_12350	COG2010	Cytochrome c
YIM_12360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
YIM_12385	COG1136	(ABC) transporter
YIM_12400	COG1876	peptidase activity
YIM_12415	COG0438	transferase activity, transferring glycosyl groups
YIM_12420	COG1595	DNA-templated transcription, initiation
YIM_12430	COG1309	transcriptional regulator
YIM_12440	COG2124	cytochrome p450
YIM_12445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YIM_12450	COG0659	secondary active sulfate transmembrane transporter activity
YIM_12455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YIM_12460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
YIM_12470	COG0501	Belongs to the peptidase M48B family
YIM_12490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YIM_12495	COG0157	Belongs to the NadC ModD family
YIM_12500	COG1404	Belongs to the peptidase S8 family
YIM_12510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YIM_12510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YIM_12535	COG1674	ftsk spoiiie
YIM_12550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YIM_12570	COG2197	response regulator
YIM_12580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YIM_12585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YIM_12590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YIM_12595	COG0131	Imidazoleglycerol-phosphate dehydratase
YIM_12605	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
YIM_12620	COG2208	phosphoserine phosphatase activity
YIM_12620	COG2770	Histidine kinase
YIM_12630	COG3959	Transketolase, thiamine diphosphate binding domain
YIM_12635	COG3958	Transketolase
YIM_12680	COG0513	Belongs to the DEAD box helicase family
YIM_12695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YIM_12710	COG1960	acyl-CoA dehydrogenase activity
YIM_12720	COG2018	Roadblock/LC7 domain
YIM_12735	COG1174	glycine betaine transport
YIM_12740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YIM_12755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YIM_12760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
YIM_12775	COG0107	imidazoleglycerol-phosphate synthase activity
YIM_12785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YIM_12800	COG1309	transcriptional regulator
YIM_12805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
YIM_12815	COG0134	indole-3-glycerol-phosphate synthase activity
YIM_12820	COG0133	tryptophan synthase activity
YIM_12825	COG0159	tryptophan synthase activity
YIM_12835	COG0601	transmembrane transport
YIM_12845	COG1124	(ABC) transporter
YIM_12855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YIM_12890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
YIM_12895	COG0070	glutamate synthase
YIM_12895	COG0069	glutamate synthase activity
YIM_12895	COG0067	glutamate synthase
YIM_12925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
YIM_12945	COG2268	Band 7 protein
YIM_12955	COG0515	serine threonine protein kinase
YIM_12955	COG2815	serine threonine protein kinase
YIM_12970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_13015	COG0583	DNA-binding transcription factor activity
YIM_13020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YIM_13065	COG0242	peptide deformylase activity
YIM_13070	COG1201	RNA secondary structure unwinding
YIM_13075	COG0443	Heat shock 70 kDa protein
YIM_13090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YIM_13095	COG2137	regulation of response to DNA damage stimulus
YIM_13105	COG0800	Aldolase
YIM_13125	COG1053	succinate dehydrogenase
YIM_13135	COG0765	amino acid transport
YIM_13140	COG0765	amino acid transport
YIM_13145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_13150	COG1126	abc transporter atp-binding protein
YIM_13160	COG2205	protein histidine kinase activity
YIM_13175	COG2337	Toxic component of a toxin-antitoxin (TA) module
YIM_13180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YIM_13195	COG1196	nuclear chromosome segregation
YIM_13205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
YIM_13210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
YIM_13590	COG2814	Major facilitator Superfamily
YIM_13600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YIM_13610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YIM_13625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YIM_13645	COG1090	epimerase
YIM_13655	COG0259	pyridoxamine-phosphate oxidase activity
YIM_13665	COG4279	zinc finger
YIM_13670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YIM_13675	COG1228	amidohydrolase
YIM_13690	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YIM_13700	COG1505	serine-type exopeptidase activity
YIM_13705	COG2321	neutral zinc metallopeptidase
YIM_13715	COG0596	Alpha beta hydrolase
YIM_13740	COG2936	dipeptidyl-peptidase activity
YIM_13765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YIM_13770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
YIM_13785	COG0123	including yeast histone deacetylase and acetoin utilization protein
YIM_13805	COG1960	acyl-CoA dehydrogenase activity
YIM_13810	COG1960	acyl-CoA dehydrogenase activity
YIM_13815	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_13825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YIM_13830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YIM_13885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YIM_13890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
YIM_13900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YIM_13905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YIM_13910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YIM_13920	COG2318	DinB family
YIM_13930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YIM_13970	COG1799	cell septum assembly
YIM_14000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
YIM_14005	COG0768	penicillin binding
YIM_14025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YIM_14030	COG0156	8-amino-7-oxononanoate synthase activity
YIM_14040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
YIM_14110	COG0003	Pfam Anion-transporting ATPase
YIM_14120	COG1940	carbohydrate kinase activity
YIM_14130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
YIM_14155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YIM_14195	COG1946	Acyl-CoA thioesterase
YIM_14220	COG1672	PFAM Archaeal ATPase
YIM_14220	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_14225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_14235	COG1012	belongs to the aldehyde dehydrogenase family
YIM_14250	COG1960	acyl-CoA dehydrogenase activity
YIM_14255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_14275	COG1566	PFAM secretion protein HlyD family protein
YIM_14300	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
YIM_14305	COG0019	diaminopimelate decarboxylase activity
YIM_14310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YIM_14325	COG2018	Roadblock/LC7 domain
YIM_14340	COG1703	isobutyryl-CoA mutase activity
YIM_14340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YIM_14340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YIM_14365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_14370	COG1309	transcriptional regulator
YIM_14375	COG1960	acyl-CoA dehydrogenase activity
YIM_14380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YIM_14385	COG2249	NAD(P)H dehydrogenase (quinone) activity
YIM_14395	COG1960	acyl-CoA dehydrogenase activity
YIM_14400	COG1960	acyl-CoA dehydrogenase activity
YIM_14425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YIM_14450	COG1960	acyl-CoA dehydrogenase activity
YIM_14455	COG2267	carboxylic ester hydrolase activity
YIM_14460	COG0346	lactoylglutathione lyase activity
YIM_14465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YIM_14480	COG1024	Enoyl-CoA hydratase
YIM_14500	COG0110	maltose O-acetyltransferase activity
YIM_14505	COG0596	Alpha beta hydrolase
YIM_14515	COG0183	Belongs to the thiolase family
YIM_14520	COG2124	cytochrome p450
YIM_14525	COG2226	methyltransferase
YIM_14550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
YIM_14555	COG1024	Enoyl-CoA hydratase
YIM_14565	COG2070	2-Nitropropane dioxygenase
YIM_14575	COG2188	Transcriptional regulator
YIM_14605	COG1490	D-aminoacyl-tRNA deacylase activity
YIM_14610	COG2890	protein-(glutamine-N5) methyltransferase activity
YIM_14620	COG1473	amidohydrolase
YIM_14635	COG2313	pseudouridylate synthase activity
YIM_14655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YIM_14670	COG4213	ABC transporter substrate-binding protein
YIM_14680	COG4214	carbohydrate transport
YIM_14700	COG2197	response regulator
YIM_14740	COG3293	Transposase
YIM_14765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YIM_14770	COG1414	Transcriptional regulator
YIM_14775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_14800	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_14815	COG3345	alpha-galactosidase
YIM_14825	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
YIM_14850	COG0028	Belongs to the TPP enzyme family
YIM_14860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
YIM_14865	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
YIM_14895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YIM_14900	COG0640	Transcriptional regulator
YIM_14910	COG1573	uracil-dna glycosylase
YIM_14930	COG0714	Associated with various cellular activities
YIM_14940	COG3552	Protein containing von Willebrand factor type A (VWA) domain
YIM_14980	COG1309	transcriptional regulator
YIM_15005	COG0725	ABC transporter, periplasmic molybdate-binding protein
YIM_15025	COG0702	epimerase
YIM_15035	COG1309	transcriptional regulator
YIM_15050	COG1695	Transcriptional regulator
YIM_15055	COG1136	(ABC) transporter
YIM_15075	COG1131	(ABC) transporter
YIM_15085	COG2197	response regulator
YIM_15090	COG2409	Drug exporters of the RND superfamily
YIM_15110	COG1309	transcriptional regulator
YIM_15150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YIM_15155	COG1819	glycosyl
YIM_15210	COG1063	alcohol dehydrogenase
YIM_15215	COG0748	coenzyme F420 binding
YIM_15225	COG0596	Alpha beta hydrolase
YIM_15230	COG3903	Transcriptional regulator
YIM_15230	COG3629	intracellular signal transduction
YIM_15235	COG0583	DNA-binding transcription factor activity
YIM_15265	COG1414	Transcriptional regulator
YIM_15280	COG3485	protocatechuate 3,4-dioxygenase
YIM_15285	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_15290	COG4829	muconolactone delta-isomerase
YIM_15345	COG1302	Protein conserved in bacteria
YIM_15365	COG2208	phosphoserine phosphatase activity
YIM_15370	COG4251	negative regulation of phosphorylation
YIM_15375	COG0784	Response regulator, receiver
YIM_15415	COG2197	response regulator
YIM_15420	COG4585	Histidine kinase
YIM_15525	COG2267	carboxylic ester hydrolase activity
YIM_15530	COG0673	inositol 2-dehydrogenase activity
YIM_15550	COG1733	regulation of RNA biosynthetic process
YIM_15600	COG0667	Aldo Keto reductase
YIM_15645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_15650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_15655	COG1120	ATPase activity
YIM_15660	COG2080	2 iron, 2 sulfur cluster binding
YIM_15665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YIM_15670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_15675	COG2207	Transcriptional regulator
YIM_15680	COG0515	serine threonine protein kinase
YIM_15680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YIM_15690	COG1309	transcriptional regulator
YIM_15695	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_15710	COG0640	Transcriptional regulator
YIM_15725	COG0702	epimerase
YIM_15755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YIM_15760	COG0066	3-isopropylmalate dehydratase activity
YIM_15765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YIM_15790	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
YIM_15800	COG3209	COG3209 Rhs family protein
YIM_15815	COG3866	Pectate lyase
YIM_15835	COG0477	Major facilitator Superfamily
YIM_15850	COG3629	intracellular signal transduction
YIM_15850	COG3903	Transcriptional regulator
YIM_15855	COG3321	synthase
YIM_15855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_15865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_15875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YIM_15905	COG3903	Transcriptional regulator
YIM_15905	COG3629	intracellular signal transduction
YIM_15910	COG0673	inositol 2-dehydrogenase activity
YIM_15920	COG2814	Major facilitator Superfamily
YIM_15925	COG0640	Transcriptional regulator
YIM_15945	COG1136	(ABC) transporter
YIM_15945	COG0577	efflux transmembrane transporter activity
YIM_15965	COG1309	transcriptional regulator
YIM_15990	COG3345	alpha-galactosidase
YIM_15995	COG3507	Belongs to the glycosyl hydrolase 43 family
YIM_16010	COG0693	protein deglycase activity
YIM_16045	COG0475	glutathione-regulated potassium exporter activity
YIM_16080	COG0798	PFAM Bile acid sodium symporter
YIM_16125	COG1595	DNA-templated transcription, initiation
YIM_16140	COG0477	Major facilitator Superfamily
YIM_16170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_16200	COG0473	3-isopropylmalate dehydrogenase activity
YIM_16205	COG1929	Belongs to the glycerate kinase type-1 family
YIM_16210	COG2814	Major facilitator Superfamily
YIM_16220	COG3896	Chloramphenicol phosphotransferase-like protein
YIM_16245	COG3629	intracellular signal transduction
YIM_16245	COG3903	Transcriptional regulator
YIM_16250	COG0583	DNA-binding transcription factor activity
YIM_16255	COG2807	transmembrane transport
YIM_16315	COG3622	Belongs to the hyi family
YIM_16350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YIM_16355	COG0247	lactate metabolic process
YIM_16355	COG0277	FAD linked oxidase domain protein
YIM_16360	COG0179	Fumarylacetoacetate (FAA) hydrolase
YIM_16365	COG3622	Belongs to the hyi family
YIM_16370	COG2084	Dehydrogenase
YIM_16375	COG3960	tartronate-semialdehyde synthase activity
YIM_16380	COG1929	Belongs to the glycerate kinase type-1 family
YIM_16405	COG0454	-acetyltransferase
YIM_16420	COG2267	carboxylic ester hydrolase activity
YIM_16430	COG0667	Aldo Keto reductase
YIM_16445	COG0583	DNA-binding transcription factor activity
YIM_16450	COG0667	Aldo Keto reductase
YIM_16460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YIM_16465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_16495	COG0697	spore germination
YIM_16510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YIM_16515	COG0747	negative chemotaxis
YIM_16530	COG0444	Belongs to the ABC transporter superfamily
YIM_16535	COG4608	Belongs to the ABC transporter superfamily
YIM_16545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YIM_16550	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_16555	COG1414	Transcriptional regulator
YIM_16560	COG0187	DNA topoisomerase II activity
YIM_16570	COG1024	Enoyl-CoA hydratase
YIM_16575	COG3903	Transcriptional regulator
YIM_16575	COG3629	intracellular signal transduction
YIM_16590	COG2203	Gaf domain
YIM_16590	COG4585	Histidine kinase
YIM_16610	COG3629	intracellular signal transduction
YIM_16610	COG3903	Transcriptional regulator
YIM_16615	COG3629	intracellular signal transduction
YIM_16615	COG3903	Transcriptional regulator
YIM_16620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
YIM_16630	COG2197	response regulator
YIM_16635	COG2267	carboxylic ester hydrolase activity
YIM_16640	COG1764	response to oxidative stress
YIM_16645	COG0488	(ABC) transporter
YIM_16650	COG0488	(ABC) transporter
YIM_16660	COG2188	Transcriptional regulator
YIM_16665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YIM_16670	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
YIM_16680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YIM_16685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_16690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YIM_16695	COG2080	2 iron, 2 sulfur cluster binding
YIM_16700	COG1309	transcriptional regulator
YIM_16710	COG1960	acyl-CoA dehydrogenase activity
YIM_16720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YIM_16735	COG0747	negative chemotaxis
YIM_16740	COG0601	transmembrane transport
YIM_16750	COG0444	Belongs to the ABC transporter superfamily
YIM_16775	COG1609	Transcriptional regulator
YIM_16780	COG2814	Major facilitator Superfamily
YIM_16800	COG3540	Alkaline phosphatase
YIM_16840	COG0022	dehydrogenase e1 component
YIM_16845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YIM_16865	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_16880	COG2188	Transcriptional regulator
YIM_16895	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_16920	COG2197	response regulator
YIM_16930	COG0577	efflux transmembrane transporter activity
YIM_16930	COG1136	(ABC) transporter
YIM_16935	COG0577	efflux transmembrane transporter activity
YIM_16950	COG0302	gtp cyclohydrolase
YIM_16960	COG1120	ATPase activity
YIM_16965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YIM_17000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YIM_17005	COG1309	transcriptional regulator
YIM_17025	COG0515	serine threonine protein kinase
YIM_17025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YIM_17080	COG1914	H( )-stimulated, divalent metal cation uptake system
YIM_17085	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_17090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YIM_17105	COG0667	Aldo Keto reductase
YIM_17110	COG4608	Belongs to the ABC transporter superfamily
YIM_17115	COG4172	Belongs to the ABC transporter superfamily
YIM_17125	COG0601	transmembrane transport
YIM_17135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YIM_17140	COG1349	DNA-binding transcription factor activity
YIM_17145	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_17160	COG1120	ATPase activity
YIM_17185	COG2124	cytochrome p450
YIM_17200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_17230	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_17255	COG1506	peptidase
YIM_17255	COG4946	Tricorn protease homolog
YIM_17255	COG0823	Involved in the tonB-independent uptake of proteins
YIM_17260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_17285	COG1309	transcriptional regulator
YIM_17290	COG3321	synthase
YIM_17290	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_17290	COG0604	alcohol dehydrogenase
YIM_17300	COG2076	Multidrug Resistance protein
YIM_17310	COG0778	Nitroreductase
YIM_17315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YIM_17340	COG1560	Kdo2-lipid A biosynthetic process
YIM_17345	COG0438	transferase activity, transferring glycosyl groups
YIM_17360	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
YIM_17370	COG1733	regulation of RNA biosynthetic process
YIM_17380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YIM_17380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YIM_17410	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
YIM_17415	COG0217	transcriptional regulatory protein
YIM_17425	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
YIM_17430	COG0632	four-way junction helicase activity
YIM_17435	COG2255	four-way junction helicase activity
YIM_17450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YIM_17455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YIM_17460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YIM_17470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YIM_17495	COG1414	Transcriptional regulator
YIM_17500	COG0747	negative chemotaxis
YIM_17515	COG4172	Belongs to the ABC transporter superfamily
YIM_17520	COG0673	inositol 2-dehydrogenase activity
YIM_17565	COG2226	methyltransferase
YIM_17575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
YIM_17620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
YIM_17640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YIM_17650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YIM_17655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YIM_17660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
YIM_17685	COG2124	cytochrome p450
YIM_17705	COG2124	cytochrome p450
YIM_17715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YIM_17720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YIM_17720	COG2190	(PTS) system
YIM_17720	COG1263	PTS System
YIM_17730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YIM_17730	COG1263	PTS System
YIM_17765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
YIM_17770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YIM_17775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
YIM_17780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YIM_17785	COG0346	lactoylglutathione lyase activity
YIM_17800	COG0006	proline dipeptidase activity
YIM_17805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YIM_17810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YIM_17820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
YIM_17825	COG0540	Belongs to the ATCase OTCase family
YIM_17840	COG0505	Belongs to the CarA family
YIM_17850	COG0284	orotidine-5'-phosphate decarboxylase activity
YIM_17860	COG0194	GDP metabolic process
YIM_17865	COG1758	RNA polymerase activity
YIM_17875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
YIM_17880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YIM_17890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YIM_17895	COG0405	Gamma-glutamyltransferase
YIM_17900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YIM_17930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YIM_17930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YIM_17935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
YIM_17955	COG0322	excinuclease ABC activity
YIM_17960	COG1660	Displays ATPase and GTPase activities
YIM_17965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YIM_17970	COG1481	regulation of sporulation
YIM_18015	COG1280	lysine exporter protein (LysE YggA)
YIM_18025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
YIM_18030	COG0126	phosphoglycerate kinase activity
YIM_18035	COG0149	triose-phosphate isomerase activity
YIM_18050	COG3850	Histidine kinase
YIM_18055	COG0363	glucosamine-6-phosphate deaminase activity
YIM_18070	COG0166	Belongs to the GPI family
YIM_18075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YIM_18085	COG0109	protoheme IX farnesyltransferase activity
YIM_18095	COG1733	regulation of RNA biosynthetic process
YIM_18100	COG3973	AAA domain
YIM_18105	COG0544	peptidyl-prolyl cis-trans isomerase activity
YIM_18110	COG0604	alcohol dehydrogenase
YIM_18160	COG0396	ATPase activity
YIM_18170	COG0822	iron-sulfur transferase activity
YIM_18180	COG0504	CTP synthase activity
YIM_18185	COG0583	DNA-binding transcription factor activity
YIM_18190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YIM_18195	COG4585	Histidine kinase
YIM_18200	COG2197	response regulator
YIM_18260	COG0488	(ABC) transporter
YIM_18275	COG1132	(ABC) transporter
YIM_18285	COG0596	Alpha beta hydrolase
YIM_18290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YIM_18295	COG1316	TRANSCRIPTIONal
YIM_18305	COG5001	Diguanylate cyclase
YIM_18315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YIM_18320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YIM_18325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YIM_18325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YIM_18335	COG1024	Enoyl-CoA hydratase
YIM_18355	COG1960	acyl-CoA dehydrogenase activity
YIM_18360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YIM_18380	COG1309	transcriptional regulator
YIM_18405	COG0596	Alpha beta hydrolase
YIM_18415	COG1309	transcriptional regulator
YIM_18420	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_18430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YIM_18440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YIM_18445	COG1024	Enoyl-CoA hydratase
YIM_18450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YIM_18455	COG1309	transcriptional regulator
YIM_18465	COG1960	acyl-CoA dehydrogenase activity
YIM_18470	COG1960	acyl-CoA dehydrogenase activity
YIM_18500	COG2186	Transcriptional regulator
YIM_18505	COG2197	response regulator
YIM_18510	COG3903	Transcriptional regulator
YIM_18510	COG3629	intracellular signal transduction
YIM_18520	COG3251	PFAM MbtH domain protein
YIM_18560	COG0704	Plays a role in the regulation of phosphate uptake
YIM_18570	COG2197	response regulator
YIM_18585	COG2197	response regulator
YIM_18600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
YIM_18630	COG0564	pseudouridine synthase activity
YIM_18660	COG1082	Xylose isomerase domain protein TIM barrel
YIM_18665	COG1070	Carbohydrate kinase
YIM_18670	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_18670	COG3347	Dehydrogenase
YIM_18715	COG4335	DNA alkylation repair
YIM_18765	COG2124	cytochrome p450
YIM_18775	COG0009	L-threonylcarbamoyladenylate synthase
YIM_18795	COG0477	Major facilitator Superfamily
YIM_18815	COG0628	permease
YIM_18825	COG0006	proline dipeptidase activity
YIM_18835	COG0531	amino acid
YIM_18855	COG1309	transcriptional regulator
YIM_18885	COG1131	(ABC) transporter
YIM_18895	COG2197	response regulator
YIM_18910	COG1228	amidohydrolase
YIM_18920	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
YIM_18945	COG2271	Major facilitator Superfamily
YIM_18950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_18970	COG1366	Belongs to the anti-sigma-factor antagonist family
YIM_18995	COG0045	succinate-CoA ligase (ADP-forming) activity
YIM_19005	COG2084	Dehydrogenase
YIM_19010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
YIM_19015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YIM_19030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_19050	COG0861	Integral membrane protein TerC family
YIM_19060	COG1802	Transcriptional regulator
YIM_19085	COG3383	formate dehydrogenase (NAD+) activity
YIM_19100	COG1280	lysine exporter protein (LysE YggA)
YIM_19130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YIM_19140	COG1414	Transcriptional regulator
YIM_19170	COG0435	Glutathione S-transferase
YIM_19200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_19205	COG0277	FAD linked oxidase domain protein
YIM_19215	COG2124	cytochrome p450
YIM_19235	COG1929	Belongs to the glycerate kinase type-1 family
YIM_19240	COG3960	tartronate-semialdehyde synthase activity
YIM_19245	COG2084	Dehydrogenase
YIM_19250	COG3622	Belongs to the hyi family
YIM_19260	COG2252	PERMEase
YIM_19265	COG0590	tRNA wobble adenosine to inosine editing
YIM_19270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_19290	COG3835	regulator
YIM_19305	COG1309	transcriptional regulator
YIM_19320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
YIM_19340	COG0028	Belongs to the TPP enzyme family
YIM_19345	COG0583	DNA-binding transcription factor activity
YIM_19350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YIM_19355	COG1053	succinate dehydrogenase
YIM_19365	COG0583	DNA-binding transcription factor activity
YIM_19375	COG2040	homocysteine
YIM_19385	COG0583	DNA-binding transcription factor activity
YIM_19410	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_19440	COG1131	(ABC) transporter
YIM_19450	COG1595	DNA-templated transcription, initiation
YIM_19460	COG0745	RESPONSE REGULATOR receiver
YIM_19460	COG3706	GGDEF domain
YIM_19475	COG1846	Transcriptional regulator
YIM_19525	COG2814	Major facilitator Superfamily
YIM_19535	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_19545	COG2936	dipeptidyl-peptidase activity
YIM_19550	COG0723	plastoquinol--plastocyanin reductase activity
YIM_19560	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_19575	COG0248	Ppx GppA phosphatase
YIM_19585	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
YIM_19595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_19600	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YIM_19605	COG2080	2 iron, 2 sulfur cluster binding
YIM_19610	COG0693	protein deglycase activity
YIM_19625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YIM_19625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YIM_19660	COG4209	transmembrane transport
YIM_19665	COG0395	ABC-type sugar transport system, permease component
YIM_19710	COG1609	Transcriptional regulator
YIM_19720	COG1175	transmembrane transport
YIM_19725	COG0395	ABC-type sugar transport system, permease component
YIM_19745	COG3940	Belongs to the glycosyl hydrolase 43 family
YIM_19760	COG0640	Transcriptional regulator
YIM_19775	COG4733	cellulase activity
YIM_19775	COG5297	Belongs to the glycosyl hydrolase family 6
YIM_19800	COG3842	ATPase activity
YIM_19805	COG2723	6-phospho-beta-galactosidase activity
YIM_19810	COG0395	ABC-type sugar transport system, permease component
YIM_19835	COG5297	Belongs to the glycosyl hydrolase family 6
YIM_19845	COG1335	isochorismatase
YIM_19855	COG0583	DNA-binding transcription factor activity
YIM_19865	COG1609	Transcriptional regulator
YIM_19895	COG1609	Transcriptional regulator
YIM_19915	COG1595	DNA-templated transcription, initiation
YIM_19955	COG3265	gluconokinase activity
YIM_19975	COG2814	Major facilitator Superfamily
YIM_19990	COG0477	Major facilitator Superfamily
YIM_20015	COG1609	Transcriptional regulator
YIM_20025	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_20030	COG0246	Mannitol dehydrogenase
YIM_20040	COG0477	Major facilitator Superfamily
YIM_20055	COG1609	Transcriptional regulator
YIM_20085	COG0477	Major facilitator Superfamily
YIM_20095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YIM_20165	COG2124	cytochrome p450
YIM_20230	COG0583	DNA-binding transcription factor activity
YIM_20235	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_20290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_20295	COG4608	Belongs to the ABC transporter superfamily
YIM_20300	COG0444	Belongs to the ABC transporter superfamily
YIM_20310	COG0747	negative chemotaxis
YIM_20315	COG2186	Transcriptional regulator
YIM_20340	COG0583	DNA-binding transcription factor activity
YIM_20350	COG2356	endonuclease I
YIM_20355	COG3291	Pkd domain containing protein
YIM_20355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
YIM_20395	COG1302	Protein conserved in bacteria
YIM_20400	COG2226	methyltransferase
YIM_20430	COG1253	flavin adenine dinucleotide binding
YIM_20435	COG1253	flavin adenine dinucleotide binding
YIM_20500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YIM_20515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YIM_20515	COG3321	synthase
YIM_20515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YIM_20515	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
YIM_20520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_20535	COG3958	Transketolase
YIM_20540	COG1454	alcohol dehydrogenase
YIM_20550	COG3958	Transketolase
YIM_20555	COG3959	Transketolase, thiamine diphosphate binding domain
YIM_20565	COG0006	proline dipeptidase activity
YIM_20570	COG1012	belongs to the aldehyde dehydrogenase family
YIM_20590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_20630	COG3226	Transcriptional regulator
YIM_20635	COG2076	Multidrug Resistance protein
YIM_20640	COG2076	Multidrug Resistance protein
YIM_20645	COG1522	sequence-specific DNA binding
YIM_20650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YIM_20665	COG1335	isochorismatase
YIM_20675	COG1609	Transcriptional regulator
YIM_20680	COG1175	transmembrane transport
YIM_20705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YIM_20715	COG2084	Dehydrogenase
YIM_20725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_20760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_20765	COG3938	Belongs to the proline racemase family
YIM_20775	COG1024	Enoyl-CoA hydratase
YIM_20790	COG0667	Aldo Keto reductase
YIM_20800	COG0745	RESPONSE REGULATOR receiver
YIM_20815	COG4585	Histidine kinase
YIM_20820	COG2197	response regulator
YIM_20830	COG2814	Major facilitator Superfamily
YIM_20840	COG0076	glutamate decarboxylase activity
YIM_20855	COG3401	FG-GAP repeat protein
YIM_20865	COG1609	Transcriptional regulator
YIM_20870	COG1609	Transcriptional regulator
YIM_20885	COG1175	transmembrane transport
YIM_20895	COG1309	transcriptional regulator
YIM_20995	COG4941	Belongs to the sigma-70 factor family
YIM_21010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YIM_21020	COG2267	carboxylic ester hydrolase activity
YIM_21025	COG2197	response regulator
YIM_21070	COG0583	DNA-binding transcription factor activity
YIM_21110	COG1119	ATPase activity
YIM_21115	COG1309	transcriptional regulator
YIM_21175	COG0475	glutathione-regulated potassium exporter activity
YIM_21190	COG0492	ferredoxin-NADP+ reductase activity
YIM_21205	COG0583	DNA-binding transcription factor activity
YIM_21215	COG1802	Transcriptional regulator
YIM_21250	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_21270	COG1486	melibiose metabolic process
YIM_21275	COG1349	DNA-binding transcription factor activity
YIM_21280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YIM_21285	COG1653	transport
YIM_21290	COG1175	transmembrane transport
YIM_21295	COG0395	ABC-type sugar transport system, permease component
YIM_21300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YIM_21310	COG2197	response regulator
YIM_21320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YIM_21320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
YIM_21325	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YIM_21330	COG2208	phosphoserine phosphatase activity
YIM_21330	COG2770	Histidine kinase
YIM_21365	COG1902	pentaerythritol trinitrate reductase activity
YIM_21365	COG0446	pyridine nucleotide-disulphide oxidoreductase
YIM_21380	COG4977	sequence-specific DNA binding
YIM_21390	COG0583	DNA-binding transcription factor activity
YIM_21395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_21410	COG0583	DNA-binding transcription factor activity
YIM_21430	COG3833	ABC-type maltose transport systems, permease component
YIM_21435	COG1175	transmembrane transport
YIM_21465	COG1609	Transcriptional regulator
YIM_21480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YIM_21485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
YIM_21505	COG0367	asparagine synthase
YIM_21545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YIM_21550	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
YIM_21560	COG0463	Glycosyl transferase, family 2
YIM_21570	COG4310	Domain of unknown function (DUF2172)
YIM_21585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
YIM_21595	COG1012	belongs to the aldehyde dehydrogenase family
YIM_21600	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
YIM_21605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YIM_21700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YIM_21745	COG1013	pyruvate-flavodoxin oxidoreductase activity
YIM_21750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YIM_21750	COG0674	pyruvate-flavodoxin oxidoreductase activity
YIM_21770	COG2267	carboxylic ester hydrolase activity
YIM_21780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YIM_21790	COG4608	Belongs to the ABC transporter superfamily
YIM_21800	COG1960	acyl-CoA dehydrogenase activity
YIM_21805	COG1960	acyl-CoA dehydrogenase activity
YIM_21845	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_21855	COG1960	acyl-CoA dehydrogenase activity
YIM_21875	COG1960	acyl-CoA dehydrogenase activity
YIM_21880	COG1960	acyl-CoA dehydrogenase activity
YIM_21890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_21895	COG1021	2,3-dihydroxybenzoate-AMP ligase
YIM_21900	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_21905	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
YIM_21915	COG2124	cytochrome p450
YIM_21925	COG4166	transmembrane transport
YIM_21930	COG0747	negative chemotaxis
YIM_21940	COG0183	Belongs to the thiolase family
YIM_21945	COG0667	Aldo Keto reductase
YIM_21955	COG2186	Transcriptional regulator
YIM_21960	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_21990	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_22030	COG2267	carboxylic ester hydrolase activity
YIM_22045	COG1309	transcriptional regulator
YIM_22090	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_22105	COG2211	Major facilitator Superfamily
YIM_22120	COG0667	Aldo Keto reductase
YIM_22155	COG0300	oxidoreductase activity
YIM_22165	COG2124	cytochrome p450
YIM_22170	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_22195	COG1024	Enoyl-CoA hydratase
YIM_22205	COG0028	Belongs to the TPP enzyme family
YIM_22215	COG1024	Enoyl-CoA hydratase
YIM_22220	COG1024	Enoyl-CoA hydratase
YIM_22235	COG0516	GMP reductase activity
YIM_22235	COG0517	IMP dehydrogenase activity
YIM_22245	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
YIM_22255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
YIM_22300	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
YIM_22325	COG1140	nitrate reductase beta subunit
YIM_22350	COG0148	phosphopyruvate hydratase activity
YIM_22375	COG3795	YCII-related domain
YIM_22380	COG4941	Belongs to the sigma-70 factor family
YIM_22395	COG0667	Aldo Keto reductase
YIM_22420	COG1309	transcriptional regulator
YIM_22430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YIM_22430	COG2022	thiamine diphosphate biosynthetic process
YIM_22435	COG0789	Transcriptional regulator
YIM_22540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YIM_22570	COG1937	Protein conserved in bacteria
YIM_22620	COG2080	2 iron, 2 sulfur cluster binding
YIM_22625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YIM_22630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_22640	COG1175	transmembrane transport
YIM_22645	COG0395	ABC-type sugar transport system, permease component
YIM_22690	COG0583	DNA-binding transcription factor activity
YIM_22695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_22700	COG1024	Enoyl-CoA hydratase
YIM_22710	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_22715	COG1960	acyl-CoA dehydrogenase activity
YIM_22750	COG4585	Histidine kinase
YIM_22770	COG2986	histidine ammonia-lyase
YIM_22775	COG1132	(ABC) transporter
YIM_22795	COG0475	glutathione-regulated potassium exporter activity
YIM_22840	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_22875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YIM_22900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YIM_22905	COG2197	response regulator
YIM_22940	COG0791	NLP P60 protein
YIM_22940	COG1388	LysM domain
YIM_22940	COG3103	Sh3 type 3 domain protein
YIM_22945	COG2197	response regulator
YIM_22950	COG0477	Major facilitator Superfamily
YIM_22955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YIM_22960	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_22965	COG2271	Major facilitator Superfamily
YIM_22975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YIM_22990	COG0667	Aldo Keto reductase
YIM_23005	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
YIM_23015	COG0778	Nitroreductase
YIM_23020	COG0745	RESPONSE REGULATOR receiver
YIM_23025	COG1960	acyl-CoA dehydrogenase activity
YIM_23030	COG1169	isochorismate synthase
YIM_23055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_23065	COG3485	protocatechuate 3,4-dioxygenase
YIM_23070	COG1454	alcohol dehydrogenase
YIM_23080	COG1012	belongs to the aldehyde dehydrogenase family
YIM_23095	COG4566	intracellular signal transduction
YIM_23100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YIM_23105	COG0154	amidase activity
YIM_23145	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_23165	COG1129	ABC transporter
YIM_23210	COG1312	Catalyzes the dehydration of D-mannonate
YIM_23220	COG0477	Major facilitator Superfamily
YIM_23235	COG0789	Transcriptional regulator
YIM_23235	COG4978	Transcriptional regulator
YIM_23240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YIM_23255	COG1073	alpha beta
YIM_23260	COG0583	DNA-binding transcription factor activity
YIM_23265	COG1335	isochorismatase
YIM_23270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_23285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YIM_23330	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_23355	COG3903	Transcriptional regulator
YIM_23355	COG3629	intracellular signal transduction
YIM_23360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YIM_23375	COG1309	transcriptional regulator
YIM_23380	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_23385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YIM_23395	COG0477	Major facilitator Superfamily
YIM_23405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YIM_23415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YIM_23415	COG4106	trans-aconitate 2-methyltransferase activity
YIM_23420	COG1278	Cold shock
YIM_23425	COG1802	Transcriptional regulator
YIM_23435	COG3842	ATPase activity
YIM_23445	COG1840	ABC-type Fe3 transport system, periplasmic component
YIM_23465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YIM_23465	COG1042	CoA-binding domain protein
YIM_23465	COG0045	succinate-CoA ligase (ADP-forming) activity
YIM_23475	COG0395	ABC-type sugar transport system, permease component
YIM_23560	COG1960	acyl-CoA dehydrogenase activity
YIM_23565	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_23570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
YIM_23575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
YIM_23580	COG0583	DNA-binding transcription factor activity
YIM_23585	COG0477	Major facilitator Superfamily
YIM_23610	COG1295	ribonuclease BN
YIM_23680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YIM_23695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YIM_23720	COG2030	dehydratase
YIM_23760	COG0583	DNA-binding transcription factor activity
YIM_23765	COG2211	Major facilitator Superfamily
YIM_23775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
YIM_23785	COG0640	Transcriptional regulator
YIM_23815	COG2239	Acts as a magnesium transporter
YIM_23905	COG0765	amino acid transport
YIM_23925	COG1024	Enoyl-CoA hydratase
YIM_23930	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_23935	COG1846	Transcriptional regulator
YIM_23940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YIM_23955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_23960	COG3903	Transcriptional regulator
YIM_23960	COG3629	intracellular signal transduction
YIM_23980	COG2207	Transcriptional regulator
YIM_23985	COG2223	nitrite transmembrane transporter activity
YIM_24005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_24035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
YIM_24050	COG4585	Histidine kinase
YIM_24055	COG2197	response regulator
YIM_24060	COG0402	S-adenosylhomocysteine deaminase activity
YIM_24070	COG2124	cytochrome p450
YIM_24090	COG1414	Transcriptional regulator
YIM_24145	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_24150	COG4221	oxidoreductase activity
YIM_24155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_24165	COG1733	regulation of RNA biosynthetic process
YIM_24170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YIM_24185	COG1349	DNA-binding transcription factor activity
YIM_24195	COG3833	ABC-type maltose transport systems, permease component
YIM_24200	COG0395	ABC-type sugar transport system, permease component
YIM_24215	COG1349	DNA-binding transcription factor activity
YIM_24220	COG0673	inositol 2-dehydrogenase activity
YIM_24235	COG1012	belongs to the aldehyde dehydrogenase family
YIM_24240	COG0506	proline dehydrogenase activity
YIM_24255	COG0667	Aldo Keto reductase
YIM_24260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_24265	COG1968	undecaprenyl-diphosphatase activity
YIM_24275	COG0339	signal peptide processing
YIM_24285	COG3104	oligopeptide transport
YIM_24290	COG0039	L-malate dehydrogenase activity
YIM_24305	COG3537	Alpha-1,2-mannosidase
YIM_24310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YIM_24320	COG4166	transmembrane transport
YIM_24325	COG0601	transmembrane transport
YIM_24330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YIM_24360	COG1619	proteins homologs of microcin C7 resistance protein MccF
YIM_24460	COG0477	Major facilitator Superfamily
YIM_24465	COG0431	NADPH-dependent FMN reductase
YIM_24480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YIM_24490	COG4941	Belongs to the sigma-70 factor family
YIM_24495	COG0667	Aldo Keto reductase
YIM_24530	COG0596	Alpha beta hydrolase
YIM_24540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YIM_24555	COG0590	tRNA wobble adenosine to inosine editing
YIM_24565	COG1522	sequence-specific DNA binding
YIM_24580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_24585	COG1960	acyl-CoA dehydrogenase activity
YIM_24590	COG4974	Belongs to the 'phage' integrase family
YIM_24600	COG2197	response regulator
YIM_24605	COG4585	Histidine kinase
YIM_24625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YIM_24625	COG0515	serine threonine protein kinase
YIM_24630	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YIM_24630	COG0515	serine threonine protein kinase
YIM_24635	COG1595	DNA-templated transcription, initiation
YIM_24670	COG2319	Wd-40 repeat
YIM_24670	COG4249	Peptidase C14 caspase catalytic subunit p20
YIM_24705	COG2205	protein histidine kinase activity
YIM_24710	COG0745	RESPONSE REGULATOR receiver
YIM_24740	COG4221	oxidoreductase activity
YIM_24755	COG1725	Transcriptional regulator
YIM_24760	COG1131	(ABC) transporter
YIM_24775	COG0640	Transcriptional regulator
YIM_24790	COG1733	regulation of RNA biosynthetic process
YIM_24805	COG4941	Belongs to the sigma-70 factor family
YIM_24810	COG3795	YCII-related domain
YIM_24840	COG0702	epimerase
YIM_24860	COG4941	Belongs to the sigma-70 factor family
YIM_24865	COG3795	YCII-related domain
YIM_24890	COG2890	protein-(glutamine-N5) methyltransferase activity
YIM_24955	COG0640	Transcriptional regulator
YIM_24975	COG1309	transcriptional regulator
YIM_24990	COG1435	thymidine kinase activity
YIM_25005	COG0463	Glycosyl transferase, family 2
YIM_25015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YIM_25055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
YIM_25070	COG1309	transcriptional regulator
YIM_25090	COG0367	asparagine synthase
YIM_25095	COG1231	oxidoreductase activity
YIM_25105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_25110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_25130	COG3483	tryptophan 2,3-dioxygenase activity
YIM_25135	COG3844	kynureninase activity
YIM_25160	COG0277	FAD linked oxidase domain protein
YIM_25170	COG2890	protein-(glutamine-N5) methyltransferase activity
YIM_25180	COG1063	alcohol dehydrogenase
YIM_25185	COG1012	belongs to the aldehyde dehydrogenase family
YIM_25195	COG2814	Major facilitator Superfamily
YIM_25220	COG0583	DNA-binding transcription factor activity
YIM_25250	COG0436	Aminotransferase
YIM_25270	COG1136	(ABC) transporter
YIM_25300	COG2318	DinB family
YIM_25350	COG1733	regulation of RNA biosynthetic process
YIM_25365	COG0477	Major facilitator Superfamily
YIM_25400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YIM_25410	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_25420	COG0583	DNA-binding transcription factor activity
YIM_25485	COG3903	Transcriptional regulator
YIM_25485	COG3629	intracellular signal transduction
YIM_25505	COG1472	Belongs to the glycosyl hydrolase 3 family
YIM_25525	COG0596	Alpha beta hydrolase
YIM_25535	COG2318	DinB family
YIM_25545	COG1309	transcriptional regulator
YIM_25550	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_25565	COG1760	l-serine dehydratase
YIM_25600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YIM_25615	COG4638	Rieske (2fe-2S)
YIM_25620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YIM_25625	COG2146	nitrite reductase [NAD(P)H] activity
YIM_25630	COG1414	Transcriptional regulator
YIM_25635	COG0477	Major facilitator Superfamily
YIM_25670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_25685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YIM_25690	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_25700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YIM_25705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YIM_25710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YIM_25725	COG2986	histidine ammonia-lyase
YIM_25735	COG1672	PFAM Archaeal ATPase
YIM_25735	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_25755	COG2814	Major facilitator Superfamily
YIM_25760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YIM_25785	COG2175	clavaminate synthase activity
YIM_25795	COG3321	synthase
YIM_25795	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_25795	COG0604	alcohol dehydrogenase
YIM_25825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_25835	COG3507	Belongs to the glycosyl hydrolase 43 family
YIM_25845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YIM_25885	COG0477	Major facilitator Superfamily
YIM_25895	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_25900	COG2197	response regulator
YIM_25905	COG4585	Histidine kinase
YIM_25920	COG0596	Alpha beta hydrolase
YIM_25960	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_25970	COG3629	intracellular signal transduction
YIM_25970	COG3903	Transcriptional regulator
YIM_25975	COG1309	transcriptional regulator
YIM_25990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YIM_25995	COG0477	Major facilitator Superfamily
YIM_26005	COG1120	ATPase activity
YIM_26010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_26015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_26025	COG2375	cellular response to nickel ion
YIM_26030	COG1535	isochorismatase
YIM_26030	COG3433	isochorismatase activity
YIM_26035	COG1535	isochorismatase
YIM_26035	COG3433	isochorismatase activity
YIM_26040	COG1021	2,3-dihydroxybenzoate-AMP ligase
YIM_26045	COG1169	isochorismate synthase
YIM_26050	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_26070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_26100	COG0667	Aldo Keto reductase
YIM_26110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YIM_26130	COG0277	FAD linked oxidase domain protein
YIM_26145	COG0477	Major facilitator Superfamily
YIM_26150	COG1846	Transcriptional regulator
YIM_26155	COG2409	Drug exporters of the RND superfamily
YIM_26205	COG2723	6-phospho-beta-galactosidase activity
YIM_26230	COG0583	DNA-binding transcription factor activity
YIM_26235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_26285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_26290	COG0697	spore germination
YIM_26320	COG1136	(ABC) transporter
YIM_26340	COG0745	RESPONSE REGULATOR receiver
YIM_26355	COG3395	kinase activity
YIM_26360	COG0235	Class ii aldolase
YIM_26365	COG1349	DNA-binding transcription factor activity
YIM_26380	COG1846	Transcriptional regulator
YIM_26460	COG1414	Transcriptional regulator
YIM_26470	COG0477	Major facilitator Superfamily
YIM_26475	COG1846	Transcriptional regulator
YIM_26480	COG1764	response to oxidative stress
YIM_26490	COG1280	lysine exporter protein (LysE YggA)
YIM_26495	COG0726	polysaccharide deacetylase
YIM_26510	COG3386	PFAM SMP-30 Gluconolaconase
YIM_26520	COG1414	Transcriptional regulator
YIM_26525	COG2017	converts alpha-aldose to the beta-anomer
YIM_26530	COG3940	Belongs to the glycosyl hydrolase 43 family
YIM_26545	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_26550	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_26560	COG1879	ABC-type sugar transport system periplasmic component
YIM_26565	COG1609	Transcriptional regulator
YIM_26600	COG0596	Alpha beta hydrolase
YIM_26620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
YIM_26630	COG3226	Transcriptional regulator
YIM_26635	COG0738	Major facilitator superfamily
YIM_26655	COG2814	Major facilitator Superfamily
YIM_26660	COG1733	regulation of RNA biosynthetic process
YIM_26670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_26675	COG0277	FAD linked oxidase domain protein
YIM_26675	COG0247	lactate metabolic process
YIM_26680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YIM_26695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YIM_26700	COG2315	Protein conserved in bacteria
YIM_26715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YIM_26725	COG3851	Histidine kinase
YIM_26730	COG2197	response regulator
YIM_26735	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YIM_26735	COG2755	lipolytic protein G-D-S-L family
YIM_26745	COG1595	DNA-templated transcription, initiation
YIM_26760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YIM_26765	COG0789	Transcriptional regulator
YIM_26785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YIM_26800	COG3345	alpha-galactosidase
YIM_26815	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_26820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YIM_26830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YIM_26835	COG0439	Biotin carboxylase
YIM_26840	COG0511	ligase activity, forming carbon-carbon bonds
YIM_26845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
YIM_26845	COG0825	malonyl-CoA metabolic process
YIM_26855	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_26885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YIM_26890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YIM_26900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YIM_26905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YIM_26925	COG2124	cytochrome p450
YIM_26935	COG0644	oxidoreductase
YIM_26960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YIM_26970	COG2226	methyltransferase
YIM_26985	COG3634	alkyl hydroperoxide reductase activity
YIM_26990	COG2226	methyltransferase
YIM_27045	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_27050	COG2197	response regulator
YIM_27055	COG0596	Alpha beta hydrolase
YIM_27060	COG0596	Alpha beta hydrolase
YIM_27105	COG0431	NADPH-dependent FMN reductase
YIM_27110	COG1733	regulation of RNA biosynthetic process
YIM_27125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YIM_27135	COG0477	Major facilitator Superfamily
YIM_27195	COG4552	Acetyltransferase involved in intracellular survival and related
YIM_27235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YIM_27245	COG2378	regulation of single-species biofilm formation
YIM_27250	COG2378	regulation of single-species biofilm formation
YIM_27265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
YIM_27275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
YIM_27280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
YIM_27325	COG1222	aaa ATPase
YIM_27345	COG0517	IMP dehydrogenase activity
YIM_27345	COG1994	Peptidase M50
YIM_27370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
YIM_27375	COG0140	phosphoribosyl-ATP diphosphatase activity
YIM_27380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YIM_27385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YIM_27390	COG0646	methionine synthase
YIM_27390	COG1410	methionine synthase
YIM_27405	COG0477	Major facilitator Superfamily
YIM_27410	COG2226	methyltransferase
YIM_27425	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_27455	COG0488	(ABC) transporter
YIM_27460	COG0488	(ABC) transporter
YIM_27465	COG0215	cysteine-tRNA ligase activity
YIM_27470	COG0789	Transcriptional regulator
YIM_27495	COG4867	von Willebrand factor, type A
YIM_27510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YIM_27520	COG1595	DNA-templated transcription, initiation
YIM_27530	COG1309	transcriptional regulator
YIM_27545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
YIM_27560	COG2205	protein histidine kinase activity
YIM_27575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YIM_27590	COG2304	oxidoreductase activity
YIM_27600	COG0714	Associated with various cellular activities
YIM_27605	COG0746	molybdenum cofactor guanylyltransferase activity
YIM_27615	COG0791	NLP P60 protein
YIM_27615	COG3883	PFAM NLP P60 protein
YIM_27630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YIM_27635	COG1285	pathogenesis
YIM_27645	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
YIM_27650	COG0121	glutamine amidotransferase
YIM_27655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
YIM_27665	COG0583	DNA-binding transcription factor activity
YIM_27670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
YIM_27695	COG1309	transcriptional regulator
YIM_27725	COG0656	L-ascorbic acid biosynthetic process
YIM_27750	COG1309	transcriptional regulator
YIM_27765	COG1716	ATPase activity
YIM_27770	COG0509	glycine decarboxylation via glycine cleavage system
YIM_27790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YIM_27800	COG2267	carboxylic ester hydrolase activity
YIM_27805	COG1648	precorrin-2 dehydrogenase activity
YIM_27805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YIM_27835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YIM_27840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YIM_27845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
YIM_27850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YIM_27885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_27920	COG1132	(ABC) transporter
YIM_27925	COG1309	transcriptional regulator
YIM_27980	COG1472	Belongs to the glycosyl hydrolase 3 family
YIM_27990	COG1477	protein flavinylation
YIM_28005	COG0745	RESPONSE REGULATOR receiver
YIM_28010	COG2205	protein histidine kinase activity
YIM_28020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YIM_28030	COG1309	transcriptional regulator
YIM_28035	COG3246	L-lysine catabolic process to acetate
YIM_28040	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_28045	COG3842	ATPase activity
YIM_28055	COG1486	melibiose metabolic process
YIM_28060	COG0395	ABC-type sugar transport system, permease component
YIM_28065	COG1175	transmembrane transport
YIM_28075	COG1940	carbohydrate kinase activity
YIM_28085	COG0488	(ABC) transporter
YIM_28090	COG0640	Transcriptional regulator
YIM_28115	COG3706	GGDEF domain
YIM_28140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YIM_28145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YIM_28175	COG4702	Belongs to the UPF0303 family
YIM_28185	COG0133	tryptophan synthase activity
YIM_28195	COG1234	tRNA 3'-trailer cleavage
YIM_28210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
YIM_28230	COG4585	Histidine kinase
YIM_28235	COG2197	response regulator
YIM_28240	COG0439	Biotin carboxylase
YIM_28245	COG5650	phosphatidylinositol metabolic process
YIM_28250	COG2197	response regulator
YIM_28255	COG4585	Histidine kinase
YIM_28260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YIM_28285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YIM_28290	COG4585	Histidine kinase
YIM_28295	COG2197	response regulator
YIM_28300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YIM_28310	COG0596	Alpha beta hydrolase
YIM_28330	COG1595	DNA-templated transcription, initiation
YIM_28355	COG0154	amidase activity
YIM_28360	COG1252	NADH dehydrogenase
YIM_28385	COG1960	acyl-CoA dehydrogenase activity
YIM_28400	COG1357	PFAM Pentapeptide repeats (8 copies)
YIM_28430	COG1131	(ABC) transporter
YIM_28435	COG1725	Transcriptional regulator
YIM_28465	COG3629	intracellular signal transduction
YIM_28465	COG3903	Transcriptional regulator
YIM_28490	COG0410	ABC transporter
YIM_28510	COG1309	transcriptional regulator
YIM_28520	COG3903	Transcriptional regulator
YIM_28520	COG3629	intracellular signal transduction
YIM_28560	COG1846	Transcriptional regulator
YIM_28565	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_28575	COG1940	carbohydrate kinase activity
YIM_28575	COG1846	Transcriptional regulator
YIM_28580	COG0395	ABC-type sugar transport system, permease component
YIM_28585	COG1175	transmembrane transport
YIM_28600	COG1082	Xylose isomerase domain protein TIM barrel
YIM_28625	COG2267	carboxylic ester hydrolase activity
YIM_28640	COG2814	Major facilitator Superfamily
YIM_28650	COG2851	Citrate transporter
YIM_28670	COG1653	transport
YIM_28685	COG0515	serine threonine protein kinase
YIM_28695	COG2815	serine threonine protein kinase
YIM_28695	COG0515	serine threonine protein kinase
YIM_28715	COG3345	alpha-galactosidase
YIM_28720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YIM_28735	COG2197	response regulator
YIM_28740	COG3629	intracellular signal transduction
YIM_28740	COG3903	Transcriptional regulator
YIM_28770	COG3209	COG3209 Rhs family protein
YIM_28770	COG4104	PAAR repeat-containing protein
YIM_28885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YIM_28960	COG0604	alcohol dehydrogenase
YIM_28960	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_28960	COG3321	synthase
YIM_28975	COG1309	transcriptional regulator
YIM_29000	COG4585	Histidine kinase
YIM_29040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YIM_29045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_29075	COG1914	H( )-stimulated, divalent metal cation uptake system
YIM_29085	COG0596	Alpha beta hydrolase
YIM_29090	COG1335	isochorismatase
YIM_29115	COG0477	Major facilitator Superfamily
YIM_29130	COG2309	aminopeptidase activity
YIM_29140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YIM_29150	COG1397	ADP-ribosylglycohydrolase
YIM_29160	COG0300	oxidoreductase activity
YIM_29220	COG0584	glycerophosphoryl diester phosphodiesterase
YIM_29235	COG1132	(ABC) transporter
YIM_29240	COG1132	(ABC) transporter
YIM_29245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_29300	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_29310	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_29325	COG2124	cytochrome p450
YIM_29330	COG0604	alcohol dehydrogenase
YIM_29330	COG3321	synthase
YIM_29375	COG3321	synthase
YIM_29375	COG0604	alcohol dehydrogenase
YIM_29400	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_29430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YIM_29435	COG0540	Belongs to the ATCase OTCase family
YIM_29455	COG1012	belongs to the aldehyde dehydrogenase family
YIM_29485	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
YIM_29485	COG0028	Belongs to the TPP enzyme family
YIM_29495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YIM_29505	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
YIM_29530	COG1960	acyl-CoA dehydrogenase activity
YIM_29540	COG1063	alcohol dehydrogenase
YIM_29545	COG1021	2,3-dihydroxybenzoate-AMP ligase
YIM_29570	COG1960	acyl-CoA dehydrogenase activity
YIM_29595	COG1960	acyl-CoA dehydrogenase activity
YIM_29600	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_29610	COG1024	Enoyl-CoA hydratase
YIM_29615	COG0477	Major facilitator Superfamily
YIM_29645	COG0494	nUDIX hydrolase
YIM_29650	COG0154	amidase activity
YIM_29745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YIM_29760	COG1674	ftsk spoiiie
YIM_29815	COG2259	Doxx family
YIM_29835	COG0484	heat shock protein binding
YIM_29850	COG1309	transcriptional regulator
YIM_29860	COG0596	Alpha beta hydrolase
YIM_29870	COG0583	DNA-binding transcription factor activity
YIM_29885	COG1733	regulation of RNA biosynthetic process
YIM_29900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_29905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YIM_29925	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_29935	COG2271	Major facilitator Superfamily
YIM_29940	COG1802	Transcriptional regulator
YIM_29960	COG2205	protein histidine kinase activity
YIM_29965	COG0745	RESPONSE REGULATOR receiver
YIM_29975	COG0789	Transcriptional regulator
YIM_29980	COG3209	COG3209 Rhs family protein
YIM_30000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
YIM_30010	COG3958	Transketolase
YIM_30015	COG3959	Transketolase, thiamine diphosphate binding domain
YIM_30040	COG0477	Major facilitator Superfamily
YIM_30085	COG0243	molybdopterin cofactor binding
YIM_30090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
YIM_30100	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_30105	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_30110	COG0583	DNA-binding transcription factor activity
YIM_30115	COG3848	Pyruvate phosphate dikinase
YIM_30115	COG0574	Belongs to the PEP-utilizing enzyme family
YIM_30130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_30135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YIM_30140	COG2080	2 iron, 2 sulfur cluster binding
YIM_30150	COG2072	flavoprotein involved in K transport
YIM_30155	COG2186	Transcriptional regulator
YIM_30165	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_30170	COG1129	ABC transporter
YIM_30205	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_30210	COG2072	flavoprotein involved in K transport
YIM_30230	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_30250	COG2072	flavoprotein involved in K transport
YIM_30270	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_30285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_30295	COG1846	Transcriptional regulator
YIM_30305	COG3226	Transcriptional regulator
YIM_30310	COG0515	serine threonine protein kinase
YIM_30310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YIM_30325	COG1959	2 iron, 2 sulfur cluster binding
YIM_30330	COG0515	serine threonine protein kinase
YIM_30330	COG2815	serine threonine protein kinase
YIM_30430	COG1929	Belongs to the glycerate kinase type-1 family
YIM_30435	COG1408	metallophosphoesterase
YIM_30440	COG1063	alcohol dehydrogenase
YIM_30445	COG0179	Fumarylacetoacetate (FAA) hydrolase
YIM_30450	COG1414	Transcriptional regulator
YIM_30455	COG0129	dihydroxy-acid dehydratase activity
YIM_30480	COG2267	carboxylic ester hydrolase activity
YIM_30500	COG0454	-acetyltransferase
YIM_30545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YIM_30550	COG0515	serine threonine protein kinase
YIM_30560	COG1609	Transcriptional regulator
YIM_30570	COG1733	regulation of RNA biosynthetic process
YIM_30580	COG2084	Dehydrogenase
YIM_30600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YIM_30610	COG0477	Major facilitator Superfamily
YIM_30665	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_30685	COG1012	belongs to the aldehyde dehydrogenase family
YIM_30690	COG0179	Fumarylacetoacetate (FAA) hydrolase
YIM_30695	COG1802	Transcriptional regulator
YIM_30700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_30705	COG1012	belongs to the aldehyde dehydrogenase family
YIM_30720	COG3629	intracellular signal transduction
YIM_30720	COG3903	Transcriptional regulator
YIM_30755	COG5650	phosphatidylinositol metabolic process
YIM_30760	COG0174	glutamine synthetase
YIM_30780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YIM_30785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YIM_30800	COG2326	polyphosphate kinase activity
YIM_30805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YIM_30820	COG0488	(ABC) transporter
YIM_30840	COG1595	DNA-templated transcription, initiation
YIM_30850	COG1302	Protein conserved in bacteria
YIM_30895	COG1793	dna ligase
YIM_30915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YIM_30920	COG0398	Pfam SNARE associated Golgi protein
YIM_30925	COG0515	serine threonine protein kinase
YIM_30925	COG2815	serine threonine protein kinase
YIM_30945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YIM_30965	COG3220	belongs to the UPF0276 family
YIM_30975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_30995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
YIM_31005	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
YIM_31010	COG3766	membrane
YIM_31030	COG2197	response regulator
YIM_31060	COG0183	Belongs to the thiolase family
YIM_31065	COG1250	3-hydroxyacyl-CoA dehydrogenase
YIM_31065	COG1024	Enoyl-CoA hydratase
YIM_31085	COG2205	protein histidine kinase activity
YIM_31090	COG0745	RESPONSE REGULATOR receiver
YIM_31115	COG1012	belongs to the aldehyde dehydrogenase family
YIM_31140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
YIM_31150	COG2755	lipolytic protein G-D-S-L family
YIM_31150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YIM_31170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YIM_31175	COG0531	amino acid
YIM_31180	COG0569	domain protein
YIM_31210	COG1280	lysine exporter protein (LysE YggA)
YIM_31220	COG0756	dUTP diphosphatase activity
YIM_31240	COG0483	inositol monophosphate 1-phosphatase activity
YIM_31260	COG1733	regulation of RNA biosynthetic process
YIM_31265	COG0488	(ABC) transporter
YIM_31270	COG1940	carbohydrate kinase activity
YIM_31275	COG1309	transcriptional regulator
YIM_31280	COG2124	cytochrome p450
YIM_31300	COG1160	GTP binding
YIM_31320	COG0475	glutathione-regulated potassium exporter activity
YIM_31335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
YIM_31340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
YIM_31370	COG0504	CTP synthase activity
YIM_31375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
YIM_31395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YIM_31410	COG0647	UMP catabolic process
YIM_31435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
YIM_31440	COG2094	Belongs to the DNA glycosylase MPG family
YIM_31465	COG0165	Argininosuccinate lyase
YIM_31470	COG1438	arginine binding
YIM_31480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YIM_31485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YIM_31490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
YIM_31495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YIM_31510	COG0072	phenylalanine-tRNA ligase activity
YIM_31510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YIM_31515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YIM_31520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YIM_31525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
YIM_31530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
YIM_31550	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YIM_31575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
YIM_31580	COG2610	gluconate transmembrane transporter activity
YIM_31585	COG2706	6-phosphogluconolactonase activity
YIM_31610	COG1051	belongs to the nudix hydrolase family
YIM_31625	COG1316	TRANSCRIPTIONal
YIM_31640	COG3290	protein histidine kinase activity
YIM_31645	COG1301	dicarboxylic acid transport
YIM_31710	COG1793	dna ligase
YIM_31710	COG3285	dna ligase
YIM_31730	COG0640	Transcriptional regulator
YIM_31740	COG1126	abc transporter atp-binding protein
YIM_31745	COG0765	amino acid transport
YIM_31750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_31765	COG3250	beta-galactosidase activity
YIM_31785	COG0702	epimerase
YIM_31790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YIM_31810	COG0667	Aldo Keto reductase
YIM_31815	COG1070	Carbohydrate kinase
YIM_31825	COG1609	Transcriptional regulator
YIM_31830	COG1879	ABC-type sugar transport system periplasmic component
YIM_31835	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_31840	COG1129	ABC transporter
YIM_31865	COG1506	peptidase
YIM_31865	COG0823	Involved in the tonB-independent uptake of proteins
YIM_31865	COG4946	Tricorn protease homolog
YIM_31870	COG0861	Integral membrane protein TerC family
YIM_31875	COG1131	(ABC) transporter
YIM_31915	COG1515	deoxyribonuclease V activity
YIM_31920	COG1131	(ABC) transporter
YIM_31935	COG4585	Histidine kinase
YIM_31940	COG2197	response regulator
YIM_31945	COG0237	dephospho-CoA kinase activity
YIM_31945	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
YIM_31960	COG3321	synthase
YIM_31960	COG0604	alcohol dehydrogenase
YIM_31960	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_31970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YIM_31975	COG2267	carboxylic ester hydrolase activity
YIM_31980	COG1819	glycosyl
YIM_31995	COG0539	negative regulation of cytoplasmic translation
YIM_32000	COG2226	methyltransferase
YIM_32020	COG1511	domain protein
YIM_32065	COG2050	protein possibly involved in aromatic compounds catabolism
YIM_32070	COG0583	DNA-binding transcription factor activity
YIM_32085	COG0411	ABC transporter
YIM_32115	COG0582	viral genome integration into host DNA
YIM_32160	COG1674	ftsk spoiiie
YIM_32215	COG2124	cytochrome p450
YIM_32220	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_32295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_32325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YIM_32335	COG1960	acyl-CoA dehydrogenase activity
YIM_32355	COG3903	Transcriptional regulator
YIM_32355	COG3629	intracellular signal transduction
YIM_32360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
YIM_32365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YIM_32370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YIM_32405	COG3209	COG3209 Rhs family protein
YIM_32440	COG1063	alcohol dehydrogenase
YIM_32445	COG0477	Major facilitator Superfamily
YIM_32450	COG0246	Mannitol dehydrogenase
YIM_32470	COG1733	regulation of RNA biosynthetic process
YIM_32480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YIM_32490	COG0297	glycogen (starch) synthase activity
YIM_32515	COG1621	beta-fructofuranosidase activity
YIM_32540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YIM_32560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YIM_32565	COG0395	ABC-type sugar transport system, permease component
YIM_32575	COG2186	Transcriptional regulator
YIM_32590	COG4221	oxidoreductase activity
YIM_32595	COG2159	amidohydrolase
YIM_32605	COG2723	6-phospho-beta-galactosidase activity
YIM_32610	COG3250	beta-galactosidase activity
YIM_32615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YIM_32630	COG2084	Dehydrogenase
YIM_32635	COG0601	transmembrane transport
YIM_32675	COG3401	FG-GAP repeat protein
YIM_32680	COG3250	beta-galactosidase activity
YIM_32690	COG1175	transmembrane transport
YIM_32695	COG0395	ABC-type sugar transport system, permease component
YIM_32775	COG4585	Histidine kinase
YIM_32780	COG2197	response regulator
YIM_32790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YIM_32795	COG2197	response regulator
YIM_32845	COG2936	dipeptidyl-peptidase activity
YIM_32850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YIM_32870	COG3629	intracellular signal transduction
YIM_32870	COG3903	Transcriptional regulator
YIM_32935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YIM_32960	COG2319	Wd-40 repeat
YIM_32960	COG4249	Peptidase C14 caspase catalytic subunit p20
YIM_32975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_32980	COG0789	Transcriptional regulator
YIM_32995	COG1309	transcriptional regulator
YIM_33000	COG1609	Transcriptional regulator
YIM_33005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_33010	COG1914	H( )-stimulated, divalent metal cation uptake system
YIM_33025	COG2226	methyltransferase
YIM_33035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YIM_33040	COG2390	Transcriptional regulator
YIM_33045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YIM_33055	COG3732	PTS system glucitol sorbitol-specific
YIM_33075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YIM_33080	COG0022	dehydrogenase e1 component
YIM_33080	COG0508	dehydrogenase complex catalyzes the overall conversion of
YIM_33085	COG0508	dehydrogenase complex catalyzes the overall conversion of
YIM_33090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YIM_33130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_33135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YIM_33140	COG2080	2 iron, 2 sulfur cluster binding
YIM_33150	COG1960	acyl-CoA dehydrogenase activity
YIM_33160	COG1960	acyl-CoA dehydrogenase activity
YIM_33165	COG1024	Enoyl-CoA hydratase
YIM_33170	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_33175	COG1960	acyl-CoA dehydrogenase activity
YIM_33185	COG0183	Belongs to the thiolase family
YIM_33190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_33210	COG1024	Enoyl-CoA hydratase
YIM_33215	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_33220	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_33250	COG1309	transcriptional regulator
YIM_33260	COG0604	alcohol dehydrogenase
YIM_33290	COG1940	carbohydrate kinase activity
YIM_33290	COG1846	Transcriptional regulator
YIM_33320	COG3706	GGDEF domain
YIM_33330	COG2272	Belongs to the type-B carboxylesterase lipase family
YIM_33365	COG1131	(ABC) transporter
YIM_33375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YIM_33380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YIM_33385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YIM_33390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_33395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_33400	COG1120	ATPase activity
YIM_33415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
YIM_33420	COG0859	PFAM glycosyl transferase family 9
YIM_33430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
YIM_33430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
YIM_33435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YIM_33445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YIM_33450	COG2192	nodulation
YIM_33455	COG0438	transferase activity, transferring glycosyl groups
YIM_33465	COG1215	transferase activity, transferring glycosyl groups
YIM_33485	COG2890	protein-(glutamine-N5) methyltransferase activity
YIM_33510	COG3546	catalase activity
YIM_33535	COG4221	oxidoreductase activity
YIM_33545	COG0148	phosphopyruvate hydratase activity
YIM_33555	COG0748	coenzyme F420 binding
YIM_33585	COG0300	oxidoreductase activity
YIM_33595	COG3257	ureidoglycine aminohydrolase activity
YIM_33600	COG3835	regulator
YIM_33635	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_33645	COG0477	Major facilitator Superfamily
YIM_33650	COG2409	Drug exporters of the RND superfamily
YIM_33720	COG1234	tRNA 3'-trailer cleavage
YIM_33740	COG1309	transcriptional regulator
YIM_33755	COG4555	ABC transporter
YIM_33795	COG4552	Acetyltransferase involved in intracellular survival and related
YIM_33810	COG3903	Transcriptional regulator
YIM_33810	COG3629	intracellular signal transduction
YIM_33845	COG0628	permease
YIM_33850	COG2409	Drug exporters of the RND superfamily
YIM_33865	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
YIM_33870	COG0477	Major facilitator Superfamily
YIM_33895	COG1309	transcriptional regulator
YIM_33910	COG3903	Transcriptional regulator
YIM_33910	COG3629	intracellular signal transduction
YIM_33920	COG0596	Alpha beta hydrolase
YIM_33925	COG0789	Transcriptional regulator
YIM_33935	COG0481	GTPase activity
YIM_33935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YIM_33955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YIM_33980	COG4585	Histidine kinase
YIM_33985	COG2197	response regulator
YIM_33990	COG0596	Alpha beta hydrolase
YIM_34005	COG0789	Transcriptional regulator
YIM_34020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_34030	COG2318	DinB family
YIM_34090	COG0587	DNA-directed DNA polymerase activity
YIM_34105	COG4585	Histidine kinase
YIM_34110	COG2197	response regulator
YIM_34130	COG2814	Major facilitator Superfamily
YIM_34160	COG1595	DNA-templated transcription, initiation
YIM_34185	COG4638	Rieske (2fe-2S)
YIM_34190	COG2264	protein methyltransferase activity
YIM_34200	COG0604	alcohol dehydrogenase
YIM_34205	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_34225	COG0477	Major facilitator Superfamily
YIM_34235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YIM_34235	COG2755	lipolytic protein G-D-S-L family
YIM_34245	COG2205	protein histidine kinase activity
YIM_34250	COG0745	RESPONSE REGULATOR receiver
YIM_34305	COG1733	regulation of RNA biosynthetic process
YIM_34360	COG1574	metal-dependent hydrolase with the TIM-barrel fold
YIM_34375	COG3509	depolymerase
YIM_34380	COG2755	lipolytic protein G-D-S-L family
YIM_34395	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_34400	COG0583	DNA-binding transcription factor activity
YIM_34470	COG3903	Transcriptional regulator
YIM_34470	COG3629	intracellular signal transduction
YIM_34495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_34510	COG0025	NhaP-type Na H and K H
YIM_34540	COG2186	Transcriptional regulator
YIM_34545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YIM_34575	COG1695	Transcriptional regulator
YIM_34585	COG1113	amino acid transport
YIM_34590	COG0745	RESPONSE REGULATOR receiver
YIM_34595	COG2205	protein histidine kinase activity
YIM_34675	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_34690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
YIM_34695	COG1674	ftsk spoiiie
YIM_34715	COG4667	esterase of the alpha-beta hydrolase superfamily
YIM_34740	COG0583	DNA-binding transcription factor activity
YIM_34755	COG3629	intracellular signal transduction
YIM_34755	COG3903	Transcriptional regulator
YIM_34765	COG1136	(ABC) transporter
YIM_34790	COG3209	COG3209 Rhs family protein
YIM_34815	COG2205	protein histidine kinase activity
YIM_34820	COG0745	RESPONSE REGULATOR receiver
YIM_34825	COG2271	Major facilitator Superfamily
YIM_34835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YIM_34840	COG1024	Enoyl-CoA hydratase
YIM_34850	COG1024	Enoyl-CoA hydratase
YIM_34855	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_34880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YIM_34900	COG0410	ABC transporter
YIM_34915	COG0559	Belongs to the binding-protein-dependent transport system permease family
YIM_34925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_34930	COG2301	Belongs to the HpcH HpaI aldolase family
YIM_34940	COG2079	MmgE PrpD family protein
YIM_34970	COG3866	Pectate lyase
YIM_34985	COG0395	ABC-type sugar transport system, permease component
YIM_35000	COG1959	2 iron, 2 sulfur cluster binding
YIM_35005	COG4941	Belongs to the sigma-70 factor family
YIM_35065	COG0456	acetyltransferase
YIM_35070	COG0740	serine-type endopeptidase activity
YIM_35080	COG1309	transcriptional regulator
YIM_35085	COG5001	Diguanylate cyclase
YIM_35095	COG2124	cytochrome p450
YIM_35125	COG1414	Transcriptional regulator
YIM_35150	COG0346	lactoylglutathione lyase activity
YIM_35190	COG2080	2 iron, 2 sulfur cluster binding
YIM_35195	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YIM_35205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YIM_35210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YIM_35215	COG2318	DinB family
YIM_35220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
YIM_35260	COG1725	Transcriptional regulator
YIM_35280	COG1063	alcohol dehydrogenase
YIM_35290	COG0022	dehydrogenase e1 component
YIM_35295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YIM_35300	COG3199	ATP-NAD kinase
YIM_35305	COG4221	oxidoreductase activity
YIM_35330	COG0514	ATP-dependent DNA helicase (RecQ)
YIM_35335	COG3537	Alpha-1,2-mannosidase
YIM_35355	COG1132	(ABC) transporter
YIM_35360	COG1132	(ABC) transporter
YIM_35385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_35390	COG2226	methyltransferase
YIM_35400	COG1309	transcriptional regulator
YIM_35405	COG0508	dehydrogenase complex catalyzes the overall conversion of
YIM_35420	COG1522	sequence-specific DNA binding
YIM_35440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YIM_35465	COG1492	cobalamin metabolic process
YIM_35470	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YIM_35480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
YIM_35485	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
YIM_35500	COG1797	cobyrinic acid a,c-diamide synthase activity
YIM_35550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YIM_35555	COG1131	(ABC) transporter
YIM_35565	COG1476	TRANSCRIPTIONal
YIM_35600	COG0640	Transcriptional regulator
YIM_35605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YIM_35625	COG0248	Ppx GppA phosphatase
YIM_35640	COG0768	penicillin binding
YIM_35650	COG0275	rRNA processing
YIM_35655	COG2001	Belongs to the MraZ family
YIM_35680	COG0714	Associated with various cellular activities
YIM_35690	COG1305	Transglutaminase-like
YIM_35710	COG2151	metal-sulfur cluster biosynthetic enzyme
YIM_35710	COG0489	protein tyrosine kinase activity
YIM_35715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YIM_35720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
YIM_35725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YIM_35730	COG0167	dihydroorotate dehydrogenase activity
YIM_35750	COG1396	sequence-specific DNA binding
YIM_35755	COG1546	Belongs to the CinA family
YIM_35755	COG1058	Belongs to the CinA family
YIM_35765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YIM_35770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
YIM_35790	COG0778	Nitroreductase
YIM_35795	COG1674	ftsk spoiiie
YIM_35820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
YIM_35825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YIM_35830	COG2815	serine threonine protein kinase
YIM_35830	COG0515	serine threonine protein kinase
YIM_35860	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_35860	COG1672	PFAM Archaeal ATPase
YIM_35870	COG0477	Major facilitator Superfamily
YIM_35875	COG3214	Protein conserved in bacteria
YIM_35900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
YIM_35905	COG0612	Peptidase, M16
YIM_35910	COG1185	polyribonucleotide nucleotidyltransferase activity
YIM_35915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
YIM_35930	COG0196	riboflavin kinase activity
YIM_35935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
YIM_35975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
YIM_35990	COG0477	Major facilitator Superfamily
YIM_36010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YIM_36025	COG0779	Required for maturation of 30S ribosomal subunits
YIM_36040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YIM_36075	COG4585	Histidine kinase
YIM_36080	COG2197	response regulator
YIM_36085	COG1733	regulation of RNA biosynthetic process
YIM_36105	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_36105	COG1672	PFAM Archaeal ATPase
YIM_36115	COG2936	dipeptidyl-peptidase activity
YIM_36120	COG0667	Aldo Keto reductase
YIM_36140	COG2022	thiamine diphosphate biosynthetic process
YIM_36155	COG0646	methionine synthase
YIM_36155	COG1410	methionine synthase
YIM_36175	COG2409	Drug exporters of the RND superfamily
YIM_36200	COG0626	cystathionine gamma-synthase activity
YIM_36220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_36235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YIM_36270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YIM_36295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YIM_36305	COG0328	RNA-DNA hybrid ribonuclease activity
YIM_36355	COG2115	Belongs to the xylose isomerase family
YIM_36360	COG1940	carbohydrate kinase activity
YIM_36360	COG1846	Transcriptional regulator
YIM_36385	COG0367	asparagine synthase
YIM_36405	COG1793	dna ligase
YIM_36405	COG3285	dna ligase
YIM_36465	COG0583	DNA-binding transcription factor activity
YIM_36470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YIM_36490	COG2072	flavoprotein involved in K transport
YIM_36535	COG1181	Belongs to the D-alanine--D-alanine ligase family
YIM_36540	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
YIM_36550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YIM_36555	COG2205	protein histidine kinase activity
YIM_36560	COG0745	RESPONSE REGULATOR receiver
YIM_36585	COG0025	NhaP-type Na H and K H
YIM_36590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
YIM_36595	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
YIM_36600	COG4585	Histidine kinase
YIM_36605	COG2197	response regulator
YIM_36620	COG1132	(ABC) transporter
YIM_36630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_36640	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_36650	COG3631	Ketosteroid isomerase-related protein
YIM_36675	COG0346	lactoylglutathione lyase activity
YIM_36680	COG2072	flavoprotein involved in K transport
YIM_36695	COG0667	Aldo Keto reductase
YIM_36710	COG0444	Belongs to the ABC transporter superfamily
YIM_36715	COG0747	negative chemotaxis
YIM_36725	COG0601	transmembrane transport
YIM_36745	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_36750	COG1053	succinate dehydrogenase
YIM_36750	COG3976	FMN-binding domain protein
YIM_36795	COG1024	Enoyl-CoA hydratase
YIM_36805	COG1414	Transcriptional regulator
YIM_36815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_36825	COG1960	acyl-CoA dehydrogenase activity
YIM_36845	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_36855	COG1218	3'(2'),5'-bisphosphate nucleotidase
YIM_36860	COG0175	sulfate reduction
YIM_36865	COG2895	sulfate adenylyltransferase (ATP) activity
YIM_36870	COG1063	alcohol dehydrogenase
YIM_36900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_36910	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_36915	COG2814	Major facilitator Superfamily
YIM_36920	COG3507	Belongs to the glycosyl hydrolase 43 family
YIM_36950	COG3250	beta-galactosidase activity
YIM_36955	COG2814	Major facilitator Superfamily
YIM_36960	COG2723	6-phospho-beta-galactosidase activity
YIM_37020	COG3903	Transcriptional regulator
YIM_37020	COG3629	intracellular signal transduction
YIM_37090	COG0210	DNA helicase
YIM_37095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YIM_37125	COG1131	(ABC) transporter
YIM_37160	COG0395	ABC-type sugar transport system, permease component
YIM_37240	COG1454	alcohol dehydrogenase
YIM_37270	COG0459	protein refolding
YIM_37320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YIM_37360	COG2226	methyltransferase
YIM_37375	COG1846	Transcriptional regulator
YIM_37400	COG1078	dGTPase activity
YIM_37415	COG1120	ATPase activity
YIM_37420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_37425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YIM_37425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YIM_37440	COG3795	YCII-related domain
YIM_37445	COG4941	Belongs to the sigma-70 factor family
YIM_37460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YIM_37480	COG0477	Major facilitator Superfamily
YIM_37510	COG2072	flavoprotein involved in K transport
YIM_37540	COG1802	Transcriptional regulator
YIM_37545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YIM_37575	COG1309	transcriptional regulator
YIM_37585	COG0137	argininosuccinate synthase activity
YIM_37610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
YIM_37640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_37655	COG3629	intracellular signal transduction
YIM_37655	COG3903	Transcriptional regulator
YIM_37680	COG1132	(ABC) transporter
YIM_37690	COG4585	Histidine kinase
YIM_37710	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_37715	COG1846	Transcriptional regulator
YIM_37735	COG2272	Belongs to the type-B carboxylesterase lipase family
YIM_37760	COG2271	Major facilitator Superfamily
YIM_37765	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_37770	COG0800	Aldolase
YIM_37780	COG1414	Transcriptional regulator
YIM_37820	COG0640	Transcriptional regulator
YIM_37860	COG0659	secondary active sulfate transmembrane transporter activity
YIM_37875	COG1609	Transcriptional regulator
YIM_37880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YIM_37895	COG3693	PFAM glycoside hydrolase, family 10
YIM_37910	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
YIM_37930	COG0477	Major facilitator Superfamily
YIM_37955	COG5310	Homospermidine synthase
YIM_38000	COG4106	trans-aconitate 2-methyltransferase activity
YIM_38010	COG0358	DNA primase activity
YIM_38015	COG1595	DNA-templated transcription, initiation
YIM_38020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_38025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_38030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_38065	COG2197	response regulator
YIM_38070	COG4585	Histidine kinase
YIM_38080	COG1131	(ABC) transporter
YIM_38085	COG0423	glycine-tRNA ligase activity
YIM_38130	COG0701	Predicted permease
YIM_38140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YIM_38145	COG1381	Involved in DNA repair and RecF pathway recombination
YIM_38180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
YIM_38185	COG3903	Transcriptional regulator
YIM_38185	COG3629	intracellular signal transduction
YIM_38200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
YIM_38210	COG0537	adenosine 5'-monophosphoramidase activity
YIM_38220	COG0484	heat shock protein binding
YIM_38225	COG1420	regulation of RNA biosynthetic process
YIM_38235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YIM_38250	COG1953	Uracil, thiamine, allantoin
YIM_38260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YIM_38300	COG0640	Transcriptional regulator
YIM_38320	COG2409	Drug exporters of the RND superfamily
YIM_38330	COG2197	response regulator
YIM_38370	COG1024	Enoyl-CoA hydratase
YIM_38375	COG2732	(Barnase) inhibitor
YIM_38390	COG0604	alcohol dehydrogenase
YIM_38395	COG2267	carboxylic ester hydrolase activity
YIM_38400	COG0531	amino acid
YIM_38405	COG2070	2-Nitropropane dioxygenase
YIM_38430	COG0481	GTPase activity
YIM_38470	COG0268	Binds directly to 16S ribosomal RNA
YIM_38490	COG1555	photosystem II stabilization
YIM_38490	COG1596	polysaccharide export
YIM_38515	COG1307	EDD domain protein, DegV family
YIM_38520	COG2755	lipolytic protein G-D-S-L family
YIM_38525	COG0406	alpha-ribazole phosphatase activity
YIM_38530	COG0799	negative regulation of ribosome biogenesis
YIM_38535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
YIM_38540	COG0514	ATP-dependent DNA helicase (RecQ)
YIM_38545	COG0477	Major facilitator Superfamily
YIM_38555	COG1309	transcriptional regulator
YIM_38565	COG1136	(ABC) transporter
YIM_38565	COG0577	efflux transmembrane transporter activity
YIM_38575	COG2197	response regulator
YIM_38590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YIM_38595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
YIM_38600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
YIM_38605	COG1530	ribonuclease E activity
YIM_38605	COG1530	ribonuclease E activity
YIM_38615	COG0842	Transport permease protein
YIM_38625	COG1131	(ABC) transporter
YIM_38640	COG2186	Transcriptional regulator
YIM_38650	COG0105	UTP biosynthetic process
YIM_38660	COG2366	antibiotic biosynthetic process
YIM_38675	COG0285	dihydrofolate synthase activity
YIM_38700	COG1082	Xylose isomerase domain protein TIM barrel
YIM_38715	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_38720	COG1129	ABC transporter
YIM_38730	COG2755	lipolytic protein G-D-S-L family
YIM_38735	COG2755	lipolytic protein G-D-S-L family
YIM_38745	COG0525	valine-tRNA ligase activity
YIM_38785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
YIM_38810	COG0740	serine-type endopeptidase activity
YIM_38820	COG0544	peptidyl-prolyl cis-trans isomerase activity
YIM_38880	COG0018	arginyl-trna synthetase
YIM_38925	COG1674	ftsk spoiiie
YIM_39000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YIM_39035	COG0477	Major facilitator Superfamily
YIM_39040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
YIM_39050	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
YIM_39065	COG0668	transmembrane transport
YIM_39075	COG0366	Alpha amylase catalytic
YIM_39105	COG2902	Dehydrogenase
YIM_39120	COG0629	single-stranded DNA binding
YIM_39215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YIM_39215	COG2755	lipolytic protein G-D-S-L family
YIM_39235	COG1695	Transcriptional regulator
YIM_39250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YIM_39260	COG0583	DNA-binding transcription factor activity
YIM_39265	COG5006	permease, DMT superfamily
YIM_39275	COG1846	Transcriptional regulator
YIM_39310	COG0640	Transcriptional regulator
YIM_39325	COG2226	methyltransferase
YIM_39330	COG0492	ferredoxin-NADP+ reductase activity
YIM_39350	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_39375	COG2197	response regulator
YIM_39405	COG0326	Molecular chaperone. Has ATPase activity
YIM_39415	COG3467	pyridoxamine 5'-phosphate
YIM_39420	COG2084	Dehydrogenase
YIM_39460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YIM_39530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_39545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YIM_39625	COG0477	Major facilitator Superfamily
YIM_39630	COG2226	methyltransferase
YIM_39655	COG1793	dna ligase
YIM_39665	COG2814	Major facilitator Superfamily
YIM_39670	COG0656	L-ascorbic acid biosynthetic process
YIM_39675	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_39680	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_39700	COG0583	DNA-binding transcription factor activity
YIM_39705	COG0667	Aldo Keto reductase
YIM_39715	COG1672	PFAM Archaeal ATPase
YIM_39715	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YIM_39750	COG0531	amino acid
YIM_39755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YIM_39790	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
YIM_39805	COG0246	Mannitol dehydrogenase
YIM_39830	COG2197	response regulator
YIM_39850	COG3254	rhamnose metabolic process
YIM_39855	COG2186	Transcriptional regulator
YIM_39860	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_39865	COG1129	ABC transporter
YIM_39875	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_39880	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_39885	COG0179	Fumarylacetoacetate (FAA) hydrolase
YIM_39905	COG3268	Saccharopine dehydrogenase
YIM_39910	COG2072	flavoprotein involved in K transport
YIM_39920	COG1796	DNA polymerase
YIM_39920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
YIM_39935	COG0366	Alpha amylase catalytic
YIM_39945	COG1175	transmembrane transport
YIM_39955	COG1609	Transcriptional regulator
YIM_39980	COG2072	flavoprotein involved in K transport
YIM_40000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
YIM_40005	COG0583	DNA-binding transcription factor activity
YIM_40035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_40065	COG3483	tryptophan 2,3-dioxygenase activity
YIM_40095	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_40100	COG1024	Enoyl-CoA hydratase
YIM_40110	COG1960	acyl-CoA dehydrogenase activity
YIM_40125	COG0583	DNA-binding transcription factor activity
YIM_40130	COG0471	metal ion transport
YIM_40135	COG0235	Class ii aldolase
YIM_40135	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YIM_40150	COG0247	lactate metabolic process
YIM_40150	COG0277	FAD linked oxidase domain protein
YIM_40160	COG0070	glutamate synthase
YIM_40160	COG0069	glutamate synthase activity
YIM_40160	COG0067	glutamate synthase
YIM_40170	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_40185	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_40190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YIM_40195	COG1132	(ABC) transporter
YIM_40200	COG1132	(ABC) transporter
YIM_40205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
YIM_40220	COG3486	L-lysine 6-monooxygenase (NADPH) activity
YIM_40225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YIM_40235	COG1278	Cold shock
YIM_40240	COG3540	Alkaline phosphatase
YIM_40245	COG4991	sh3 domain protein
YIM_40250	COG3629	intracellular signal transduction
YIM_40250	COG3903	Transcriptional regulator
YIM_40255	COG4991	sh3 domain protein
YIM_40280	COG0300	oxidoreductase activity
YIM_40385	COG0577	efflux transmembrane transporter activity
YIM_40390	COG0577	efflux transmembrane transporter activity
YIM_40390	COG1136	(ABC) transporter
YIM_40410	COG0642	Histidine kinase
YIM_40415	COG0745	RESPONSE REGULATOR receiver
YIM_40420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YIM_40455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YIM_40470	COG1522	sequence-specific DNA binding
YIM_40475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
YIM_40495	COG4715	Zinc finger, swim domain protein
YIM_40500	COG3552	Protein containing von Willebrand factor type A (VWA) domain
YIM_40505	COG2425	protein containing a von Willebrand factor type A (vWA) domain
YIM_40510	COG0714	Associated with various cellular activities
YIM_40515	COG3831	ATPase activity
YIM_40540	COG0515	serine threonine protein kinase
YIM_40540	COG2815	serine threonine protein kinase
YIM_40555	COG0714	Associated with various cellular activities
YIM_40565	COG2205	protein histidine kinase activity
YIM_40575	COG3903	Transcriptional regulator
YIM_40575	COG3629	intracellular signal transduction
YIM_40585	COG0745	RESPONSE REGULATOR receiver
YIM_40610	COG0175	sulfate reduction
YIM_40630	COG0583	DNA-binding transcription factor activity
YIM_40640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YIM_40645	COG0187	DNA topoisomerase II activity
YIM_40670	COG0515	serine threonine protein kinase
YIM_40685	COG3012	SEC-C Motif Domain Protein
YIM_40730	COG0640	Transcriptional regulator
YIM_40760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YIM_40835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_40840	COG0367	asparagine synthase
YIM_40855	COG1794	racemase activity, acting on amino acids and derivatives
YIM_40865	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_40870	COG1960	acyl-CoA dehydrogenase activity
YIM_40875	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_40880	COG1960	acyl-CoA dehydrogenase activity
YIM_40935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YIM_40940	COG1960	acyl-CoA dehydrogenase activity
YIM_40950	COG0477	Major facilitator Superfamily
YIM_40970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YIM_41005	COG2124	cytochrome p450
YIM_41030	COG4977	sequence-specific DNA binding
YIM_41030	COG1917	Cupin 2, conserved barrel domain protein
YIM_41040	COG2197	response regulator
YIM_41045	COG4585	Histidine kinase
YIM_41065	COG3629	intracellular signal transduction
YIM_41070	COG1733	regulation of RNA biosynthetic process
YIM_41075	COG1045	serine acetyltransferase
YIM_41080	COG0367	asparagine synthase
YIM_41085	COG0523	cobalamin synthesis protein
YIM_41090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
YIM_41105	COG5002	protein histidine kinase activity
YIM_41110	COG0745	RESPONSE REGULATOR receiver
YIM_41115	COG3706	GGDEF domain
YIM_41115	COG0745	RESPONSE REGULATOR receiver
YIM_41165	COG0640	Transcriptional regulator
YIM_41170	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_41175	COG0235	Class ii aldolase
YIM_41185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YIM_41190	COG0698	ribose 5-phosphate isomerase
YIM_41195	COG2376	Dihydroxyacetone kinase
YIM_41200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YIM_41205	COG0588	phosphoglycerate mutase activity
YIM_41210	COG1349	DNA-binding transcription factor activity
YIM_41215	COG2814	Major facilitator Superfamily
YIM_41220	COG1070	Carbohydrate kinase
YIM_41240	COG3655	Transcriptional regulator
YIM_41245	COG1733	regulation of RNA biosynthetic process
YIM_41255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YIM_41275	COG1295	ribonuclease BN
YIM_41280	COG2272	Belongs to the type-B carboxylesterase lipase family
YIM_41285	COG1309	transcriptional regulator
YIM_41315	COG2223	nitrite transmembrane transporter activity
YIM_41325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YIM_41330	COG1609	Transcriptional regulator
YIM_41350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YIM_41355	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
YIM_41380	COG1959	2 iron, 2 sulfur cluster binding
YIM_41395	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
YIM_41405	COG2197	response regulator
YIM_41410	COG4585	Histidine kinase
YIM_41425	COG1309	transcriptional regulator
YIM_41435	COG0587	DNA-directed DNA polymerase activity
YIM_41445	COG1309	transcriptional regulator
YIM_41475	COG2261	transglycosylase associated protein
YIM_41480	COG0640	Transcriptional regulator
YIM_41515	COG2186	Transcriptional regulator
YIM_41525	COG2201	protein-glutamate methylesterase activity
YIM_41575	COG1733	regulation of RNA biosynthetic process
YIM_41600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YIM_41605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
YIM_41615	COG1234	tRNA 3'-trailer cleavage
YIM_41620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
YIM_41630	COG0823	Involved in the tonB-independent uptake of proteins
YIM_41635	COG0705	Rhomboid family
YIM_41640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YIM_41655	COG0583	DNA-binding transcription factor activity
YIM_41685	COG3191	aminopeptidase activity
YIM_41695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
YIM_41700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
YIM_41705	COG1335	isochorismatase
YIM_41745	COG3830	Belongs to the UPF0237 family
YIM_41745	COG0560	Phosphoserine phosphatase
YIM_41750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YIM_41755	COG2318	DinB family
YIM_41765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
YIM_41765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YIM_41770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YIM_41790	COG1012	belongs to the aldehyde dehydrogenase family
YIM_41795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YIM_41800	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YIM_41870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YIM_41895	COG2197	response regulator
YIM_41900	COG3265	gluconokinase activity
YIM_41905	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YIM_41925	COG1609	Transcriptional regulator
YIM_41950	COG3509	depolymerase
YIM_41965	COG2197	response regulator
YIM_41980	COG1595	DNA-templated transcription, initiation
YIM_41990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YIM_42000	COG0328	RNA-DNA hybrid ribonuclease activity
YIM_42000	COG0406	alpha-ribazole phosphatase activity
YIM_42015	COG0612	Peptidase, M16
YIM_42050	COG0714	Associated with various cellular activities
YIM_42080	COG1309	transcriptional regulator
YIM_42095	COG0210	DNA helicase
YIM_42100	COG0210	DNA helicase
YIM_42120	COG2378	regulation of single-species biofilm formation
YIM_42155	COG0148	phosphopyruvate hydratase activity
YIM_42160	COG2146	nitrite reductase [NAD(P)H] activity
YIM_42160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YIM_42165	COG2146	nitrite reductase [NAD(P)H] activity
YIM_42165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YIM_42175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YIM_42180	COG0243	molybdopterin cofactor binding
YIM_42200	COG2267	carboxylic ester hydrolase activity
YIM_42210	COG2267	carboxylic ester hydrolase activity
YIM_42245	COG0513	Belongs to the DEAD box helicase family
YIM_42270	COG2095	MarC family integral membrane protein
YIM_42275	COG0613	PHP domain protein
YIM_42305	COG0598	Magnesium transport protein CorA
YIM_42365	COG0330	HflC and HflK could
YIM_42370	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
YIM_42375	COG2239	Acts as a magnesium transporter
YIM_42390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YIM_42395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YIM_42410	COG4122	O-methyltransferase activity
YIM_42415	COG2814	Major facilitator Superfamily
YIM_42420	COG0583	DNA-binding transcription factor activity
YIM_42425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YIM_42435	COG1024	Enoyl-CoA hydratase
YIM_42440	COG0519	Catalyzes the synthesis of GMP from XMP
YIM_42465	COG1271	oxidase subunit
YIM_42475	COG4988	ABC transporter
YIM_42480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YIM_42495	COG1611	Belongs to the LOG family
YIM_42525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YIM_42560	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
YIM_42560	COG0778	Nitroreductase
YIM_42575	COG1725	Transcriptional regulator
YIM_42610	COG0438	transferase activity, transferring glycosyl groups
YIM_42640	COG1316	TRANSCRIPTIONal
YIM_42645	COG1316	TRANSCRIPTIONal
YIM_42655	COG2259	Doxx family
YIM_42680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YIM_42690	COG5479	isomerase activity
YIM_42690	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
YIM_42695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YIM_42705	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_42710	COG2814	Major facilitator Superfamily
YIM_42715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YIM_42730	COG1960	acyl-CoA dehydrogenase activity
YIM_42735	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_42785	COG2205	protein histidine kinase activity
YIM_42790	COG0745	RESPONSE REGULATOR receiver
YIM_42795	COG0483	inositol monophosphate 1-phosphatase activity
YIM_42835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
YIM_42835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
YIM_42840	COG1388	LysM domain
YIM_42840	COG0791	NLP P60 protein
YIM_42840	COG3103	Sh3 type 3 domain protein
YIM_42865	COG1725	Transcriptional regulator
YIM_42885	COG0596	Alpha beta hydrolase
YIM_42900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YIM_42925	COG0424	maF-like protein
YIM_42930	COG1301	dicarboxylic acid transport
YIM_42975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YIM_42980	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
YIM_42985	COG0235	Class ii aldolase
YIM_42990	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
YIM_42995	COG4770	biotin carboxylase activity
YIM_43010	COG2197	response regulator
YIM_43020	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_43025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YIM_43030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YIM_43035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YIM_43060	COG1473	amidohydrolase
YIM_43060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
YIM_43085	COG0515	serine threonine protein kinase
YIM_43100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YIM_43105	COG0706	membrane insertase activity
YIM_43135	COG3973	AAA domain
YIM_43150	COG0477	Major facilitator Superfamily
YIM_43160	COG0667	Aldo Keto reductase
YIM_43165	COG0667	Aldo Keto reductase
YIM_43170	COG0789	Transcriptional regulator
YIM_43190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YIM_43195	COG1012	belongs to the aldehyde dehydrogenase family
YIM_43200	COG1012	belongs to the aldehyde dehydrogenase family
YIM_43245	COG2271	Major facilitator Superfamily
YIM_43250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
YIM_43290	COG1082	Xylose isomerase domain protein TIM barrel
YIM_43295	COG3345	alpha-galactosidase
YIM_43310	COG2009	succinate dehydrogenase
YIM_43325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YIM_43380	COG2814	Major facilitator Superfamily
YIM_43385	COG1295	ribonuclease BN
YIM_43405	COG0180	Tryptophanyl-tRNA synthetase
YIM_43415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
YIM_43440	COG0708	Exodeoxyribonuclease III
YIM_43490	COG2814	Major facilitator Superfamily
YIM_43495	COG0640	Transcriptional regulator
YIM_43520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
YIM_43545	COG1228	amidohydrolase
YIM_43560	COG0587	DNA-directed DNA polymerase activity
YIM_43595	COG0138	bifunctional purine biosynthesis protein purh
YIM_43620	COG0045	succinate-CoA ligase (ADP-forming) activity
YIM_43675	COG2815	serine threonine protein kinase
YIM_43675	COG0515	serine threonine protein kinase
YIM_43680	COG0583	DNA-binding transcription factor activity
YIM_43685	COG0697	spore germination
YIM_43690	COG2197	response regulator
YIM_43710	COG0519	Catalyzes the synthesis of GMP from XMP
YIM_43710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YIM_43720	COG1012	belongs to the aldehyde dehydrogenase family
YIM_43740	COG0516	GMP reductase activity
YIM_43795	COG1309	transcriptional regulator
YIM_43800	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_43805	COG0459	protein refolding
YIM_43810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
YIM_43815	COG3540	Alkaline phosphatase
YIM_43825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
YIM_43830	COG0456	acetyltransferase
YIM_43850	COG2186	Transcriptional regulator
YIM_43860	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_43865	COG0825	malonyl-CoA metabolic process
YIM_43865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
YIM_43870	COG0154	amidase activity
YIM_43875	COG3458	cephalosporin-C deacetylase activity
YIM_43880	COG0802	atpase or kinase
YIM_43890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YIM_43895	COG3842	ATPase activity
YIM_43900	COG1070	Carbohydrate kinase
YIM_43905	COG1063	alcohol dehydrogenase
YIM_43910	COG1349	DNA-binding transcription factor activity
YIM_43915	COG1063	alcohol dehydrogenase
YIM_43920	COG0395	ABC-type sugar transport system, permease component
YIM_43940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YIM_43970	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_43990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YIM_43995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
YIM_44000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YIM_44040	COG0443	Heat shock 70 kDa protein
YIM_44045	COG1674	ftsk spoiiie
YIM_44055	COG1404	Belongs to the peptidase S8 family
YIM_44095	COG0101	tRNA pseudouridine synthase activity
YIM_44100	COG0203	ribosomal protein L17
YIM_44105	COG0202	RNA polymerase activity
YIM_44110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YIM_44115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
YIM_44125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YIM_44130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YIM_44135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YIM_44145	COG0563	adenylate kinase activity
YIM_44155	COG1280	lysine exporter protein (LysE YggA)
YIM_44165	COG0200	Binds to the 23S rRNA
YIM_44170	COG1841	ribosomal large subunit assembly
YIM_44175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YIM_44180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
YIM_44185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
YIM_44190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YIM_44200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YIM_44205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
YIM_44210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YIM_44215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YIM_44220	COG0255	Belongs to the universal ribosomal protein uL29 family
YIM_44225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YIM_44230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YIM_44235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YIM_44240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YIM_44245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YIM_44250	COG0089	rRNA binding
YIM_44255	COG0088	Forms part of the polypeptide exit tunnel
YIM_44260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YIM_44275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YIM_44280	COG0049	tRNA binding
YIM_44285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YIM_44315	COG0084	hydrolase, TatD family'
YIM_44325	COG0109	protoheme IX farnesyltransferase activity
YIM_44335	COG3507	Belongs to the glycosyl hydrolase 43 family
YIM_44340	COG0673	inositol 2-dehydrogenase activity
YIM_44350	COG1172	Belongs to the binding-protein-dependent transport system permease family
YIM_44355	COG1129	ABC transporter
YIM_44365	COG1940	carbohydrate kinase activity
YIM_44415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
YIM_44420	COG2197	response regulator
YIM_44425	COG4585	Histidine kinase
YIM_44450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YIM_44500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YIM_44515	COG0222	ribosome binding
YIM_44520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YIM_44540	COG0081	regulation of translation
YIM_44545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
YIM_44565	COG0436	Aminotransferase
YIM_44575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_44595	COG2030	dehydratase
YIM_44605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YIM_44635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YIM_44640	COG0586	Pfam SNARE associated Golgi protein
YIM_44645	COG4585	Histidine kinase
YIM_44650	COG2197	response regulator
YIM_44655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YIM_44665	COG1309	transcriptional regulator
YIM_44725	COG2186	Transcriptional regulator
YIM_44735	COG1660	Displays ATPase and GTPase activities
YIM_44775	COG0270	DNA (cytosine-5-)-methyltransferase activity
YIM_44805	COG1666	GTP binding
YIM_44815	COG1309	transcriptional regulator
YIM_44820	COG0596	Alpha beta hydrolase
YIM_44825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YIM_44850	COG0673	inositol 2-dehydrogenase activity
YIM_44860	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
YIM_44860	COG2146	nitrite reductase [NAD(P)H] activity
YIM_44870	COG0438	transferase activity, transferring glycosyl groups
YIM_44875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YIM_44890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YIM_44935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YIM_44965	COG1215	transferase activity, transferring glycosyl groups
YIM_44970	COG1834	amidinotransferase
YIM_44975	COG1522	sequence-specific DNA binding
YIM_44985	COG0674	pyruvate-flavodoxin oxidoreductase activity
YIM_44985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YIM_44990	COG1013	pyruvate-flavodoxin oxidoreductase activity
YIM_45060	COG1007	ATP synthesis coupled electron transport
YIM_45075	COG0713	ATP synthesis coupled electron transport
YIM_45080	COG0839	Belongs to the complex I subunit 6 family
YIM_45085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YIM_45090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
YIM_45095	COG1034	ATP synthesis coupled electron transport
YIM_45110	COG0649	NAD binding
YIM_45115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YIM_45120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YIM_45135	COG2226	methyltransferase
YIM_45140	COG0438	transferase activity, transferring glycosyl groups
YIM_45150	COG0483	inositol monophosphate 1-phosphatase activity
YIM_45165	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
YIM_45170	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
YIM_45175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YIM_45195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YIM_45205	COG1522	sequence-specific DNA binding
YIM_45225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YIM_45245	COG0406	alpha-ribazole phosphatase activity
YIM_45250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YIM_45260	COG1136	(ABC) transporter
YIM_45260	COG0577	efflux transmembrane transporter activity
YIM_45265	COG1136	(ABC) transporter
YIM_45265	COG0577	efflux transmembrane transporter activity
YIM_45270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YIM_45295	COG1648	precorrin-2 dehydrogenase activity
YIM_45295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YIM_45300	COG0181	hydroxymethylbilane synthase activity
YIM_45305	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
YIM_45310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
YIM_45315	COG3903	Transcriptional regulator
YIM_45315	COG3629	intracellular signal transduction
YIM_45350	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_45355	COG1595	DNA-templated transcription, initiation
YIM_45365	COG0560	Phosphoserine phosphatase
YIM_45370	COG0204	Acyl-transferase
YIM_45390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YIM_45400	COG0506	proline dehydrogenase activity
YIM_45425	COG5002	protein histidine kinase activity
YIM_45430	COG0667	Aldo Keto reductase
YIM_45465	COG0438	transferase activity, transferring glycosyl groups
YIM_45480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YIM_45500	COG0788	formyltetrahydrofolate deformylase activity
YIM_45510	COG2130	NADP-dependent
YIM_45525	COG1174	glycine betaine transport
YIM_45530	COG1174	glycine betaine transport
YIM_45535	COG2986	histidine ammonia-lyase
YIM_45565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
YIM_45570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YIM_45570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YIM_45590	COG4941	Belongs to the sigma-70 factor family
YIM_45595	COG3795	YCII-related domain
YIM_45605	COG2733	membrane
YIM_45625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YIM_45630	COG2364	Membrane
YIM_45700	COG1027	Aspartate ammonia-lyase
YIM_45730	COG1674	ftsk spoiiie
YIM_45750	COG2188	Transcriptional regulator
YIM_45755	COG0546	phosphoglycolate phosphatase activity
YIM_45790	COG1278	Cold shock
YIM_45805	COG1595	DNA-templated transcription, initiation
YIM_45815	COG0477	Major facilitator Superfamily
YIM_45825	COG1408	metallophosphoesterase
YIM_45830	COG0515	serine threonine protein kinase
YIM_45840	COG1012	belongs to the aldehyde dehydrogenase family
YIM_45845	COG4948	Mandelate Racemase Muconate Lactonizing
YIM_45850	COG1414	Transcriptional regulator
YIM_45855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_45865	COG2197	response regulator
YIM_45870	COG4585	Histidine kinase
YIM_45895	COG1132	(ABC) transporter
YIM_45900	COG1132	(ABC) transporter
YIM_45910	COG0515	serine threonine protein kinase
YIM_45915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YIM_45960	COG0443	Heat shock 70 kDa protein
YIM_46015	COG1309	transcriptional regulator
YIM_46020	COG1064	alcohol dehydrogenase
YIM_46035	COG1309	transcriptional regulator
YIM_46045	COG0640	Transcriptional regulator
YIM_46060	COG2272	Belongs to the type-B carboxylesterase lipase family
YIM_46100	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_46145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YIM_46190	COG1316	TRANSCRIPTIONal
YIM_46200	COG3706	GGDEF domain
YIM_46200	COG0745	RESPONSE REGULATOR receiver
YIM_46210	COG0318	PFAM AMP-dependent synthetase and ligase
YIM_46210	COG0204	Acyl-transferase
YIM_46245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
YIM_46260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YIM_46265	COG0454	-acetyltransferase
YIM_46265	COG0456	acetyltransferase
YIM_46270	COG0745	RESPONSE REGULATOR receiver
YIM_46280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YIM_46305	COG4044	May play a role in the intracellular transport of hydrophobic ligands
YIM_46310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YIM_46315	COG1984	allophanate hydrolase subunit 2
YIM_46325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YIM_46365	COG3845	ABC transporter
YIM_46410	COG3181	Tripartite tricarboxylate transporter family receptor
YIM_46415	COG3290	protein histidine kinase activity
YIM_46420	COG4565	transcriptional regulatory protein
YIM_46435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
YIM_46510	COG1132	(ABC) transporter
YIM_46515	COG1132	(ABC) transporter
YIM_46520	COG0047	phosphoribosylformylglycinamidine synthase activity
YIM_46525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
YIM_46565	COG0730	response to heat
YIM_46575	COG1126	abc transporter atp-binding protein
YIM_46580	COG0765	amino acid transport
YIM_46585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YIM_46595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YIM_46640	COG0436	Aminotransferase
YIM_46645	COG1376	ErfK ybiS ycfS ynhG family protein
YIM_46650	COG5280	Phage tail tape measure protein TP901
YIM_46650	COG3953	SLT domain
YIM_46665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YIM_46665	COG0515	serine threonine protein kinase
YIM_46710	COG0584	glycerophosphoryl diester phosphodiesterase
YIM_46715	COG2814	Major facilitator Superfamily
YIM_46725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YIM_46765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YIM_46800	COG0586	Pfam SNARE associated Golgi protein
YIM_46805	COG0277	FAD linked oxidase domain protein
YIM_46820	COG0477	Major facilitator Superfamily
YIM_46840	COG2353	YceI-like domain
YIM_46845	COG0586	Pfam SNARE associated Golgi protein
YIM_46855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
YIM_46860	COG2188	Transcriptional regulator
YIM_46865	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_46870	COG1072	(Pantothenic acid kinase))
YIM_46910	COG0243	molybdopterin cofactor binding
YIM_46915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YIM_46935	COG0300	oxidoreductase activity
YIM_46945	COG0542	response to heat
YIM_46965	COG0789	Transcriptional regulator
YIM_46970	COG0484	heat shock protein binding
YIM_46975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YIM_46980	COG0443	Heat shock 70 kDa protein
YIM_47020	COG2181	nitrate reductase activity
YIM_47020	COG0247	lactate metabolic process
YIM_47025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YIM_47035	COG1522	sequence-specific DNA binding
YIM_47055	COG1309	transcriptional regulator
YIM_47060	COG1960	acyl-CoA dehydrogenase activity
YIM_47070	COG2340	Cysteine-rich secretory protein family
YIM_47120	COG0737	Belongs to the 5'-nucleotidase family
YIM_47120	COG1525	nuclease
YIM_47120	COG4085	toxin activity
YIM_47140	COG3663	DNA glycosylase
YIM_47145	COG2197	response regulator
YIM_47150	COG1960	acyl-CoA dehydrogenase activity
YIM_47175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
YIM_47180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YIM_47200	COG0765	amino acid transport
YIM_47220	COG1305	Transglutaminase-like
YIM_47230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YIM_47240	COG0022	dehydrogenase e1 component
YIM_47245	COG0508	dehydrogenase complex catalyzes the overall conversion of
YIM_47260	COG1132	(ABC) transporter
YIM_47270	COG3030	protein affecting phage T7 exclusion by the F plasmid
YIM_47285	COG1309	transcriptional regulator
YIM_47290	COG2030	dehydratase
YIM_47295	COG1028	Short-chain dehydrogenase reductase Sdr
YIM_47300	COG0183	Belongs to the thiolase family
YIM_47310	COG0584	glycerophosphoryl diester phosphodiesterase
YIM_47320	COG0789	Transcriptional regulator
YIM_47335	COG1846	Transcriptional regulator
YIM_47335	COG0456	acetyltransferase
YIM_47395	COG4133	protoheme IX ABC transporter activity
YIM_47400	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
YIM_47440	COG4585	Histidine kinase
YIM_47445	COG2197	response regulator
YIM_47465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
YIM_47475	COG1136	(ABC) transporter
YIM_47485	COG2197	response regulator
YIM_47490	COG0402	S-adenosylhomocysteine deaminase activity
YIM_47505	COG2197	response regulator
YIM_47510	COG4585	Histidine kinase
YIM_47520	COG4221	oxidoreductase activity
YIM_47540	COG0842	Transport permease protein
YIM_47555	COG2814	Major facilitator Superfamily
YIM_47780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YIM_47785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YIM_47815	COG2814	Major facilitator Superfamily
YIM_47820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YIM_47855	COG1695	Transcriptional regulator
YIM_47865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YIM_47870	COG1228	amidohydrolase
YIM_47875	COG0673	inositol 2-dehydrogenase activity
YIM_47880	COG1940	carbohydrate kinase activity
YIM_47915	COG0360	Binds together with S18 to 16S ribosomal RNA
YIM_47925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YIM_47930	COG0359	binds to the 23S rRNA
YIM_47970	COG2267	carboxylic ester hydrolase activity
YIM_48015	COG3384	dioxygenase
YIM_48040	COG2197	response regulator
YIM_48055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YIM_48065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YIM_48095	COG0495	leucyl-tRNA aminoacylation
YIM_48110	COG1678	Uncharacterized ACR, COG1678
YIM_48170	COG4585	Histidine kinase
YIM_48195	COG0765	amino acid transport
YIM_48200	COG0765	amino acid transport
YIM_48230	COG3118	belongs to the thioredoxin family
YIM_48230	COG0492	ferredoxin-NADP+ reductase activity
YIM_48235	COG3409	Peptidoglycan-binding domain 1 protein
YIM_48235	COG0860	N-Acetylmuramoyl-L-alanine amidase
YIM_48250	COG1181	Belongs to the D-alanine--D-alanine ligase family
YIM_48260	COG1192	Involved in chromosome partitioning
YIM_48265	COG0357	Ribosomal RNA small subunit methyltransferase G
YIM_48285	COG0706	membrane insertase activity