locus-tag	class	description
L1857_00020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1857_00040	COG1408	metallophosphoesterase
L1857_00060	COG0783	Belongs to the Dps family
L1857_00065	COG1764	response to oxidative stress
L1857_00075	COG0657	acetylesterase activity
L1857_00115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L1857_00120	COG0667	Aldo Keto reductase
L1857_00165	COG1132	(ABC) transporter
L1857_00170	COG1132	(ABC) transporter
L1857_00180	COG0515	serine threonine protein kinase
L1857_00190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_00200	COG0583	DNA-binding transcription factor activity
L1857_00205	COG0697	spore germination
L1857_00215	COG4608	Belongs to the ABC transporter superfamily
L1857_00220	COG0444	Belongs to the ABC transporter superfamily
L1857_00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_00230	COG0601	transmembrane transport
L1857_00235	COG0747	negative chemotaxis
L1857_00245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L1857_00250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1857_00255	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1857_00270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L1857_00280	COG2205	protein histidine kinase activity
L1857_00285	COG0745	RESPONSE REGULATOR receiver
L1857_00315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L1857_00335	COG1959	2 iron, 2 sulfur cluster binding
L1857_00345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L1857_00355	COG5001	Diguanylate cyclase
L1857_00450	COG1278	Cold shock
L1857_00470	COG0477	Major facilitator Superfamily
L1857_00480	COG0515	serine threonine protein kinase
L1857_00485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_00540	COG2188	Transcriptional regulator
L1857_00610	COG2391	methyltransferase activity
L1857_00615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1857_00620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1857_00645	COG1609	Transcriptional regulator
L1857_00650	COG2814	Major facilitator Superfamily
L1857_00660	COG3250	beta-galactosidase activity
L1857_00680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1857_00735	COG0477	Major facilitator Superfamily
L1857_00740	COG1960	acyl-CoA dehydrogenase activity
L1857_00745	COG1309	transcriptional regulator
L1857_00765	COG0247	lactate metabolic process
L1857_00765	COG2181	nitrate reductase activity
L1857_00770	COG2076	Multidrug Resistance protein
L1857_00795	COG0443	Heat shock 70 kDa protein
L1857_00805	COG0484	heat shock protein binding
L1857_00810	COG0789	Transcriptional regulator
L1857_00815	COG2801	Transposase and inactivated derivatives
L1857_00825	COG0412	Dienelactone hydrolase
L1857_00840	COG0477	Major facilitator Superfamily
L1857_00850	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_00855	COG0542	response to heat
L1857_00865	COG4221	oxidoreductase activity
L1857_00875	COG2318	DinB family
L1857_00890	COG1053	succinate dehydrogenase
L1857_00895	COG2223	nitrite transmembrane transporter activity
L1857_00900	COG0583	DNA-binding transcription factor activity
L1857_00920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_00925	COG0243	molybdopterin cofactor binding
L1857_00935	COG1609	Transcriptional regulator
L1857_00960	COG1072	(Pantothenic acid kinase))
L1857_00965	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_01000	COG0586	Pfam SNARE associated Golgi protein
L1857_01005	COG2353	YceI-like domain
L1857_01015	COG1846	Transcriptional regulator
L1857_01020	COG0277	FAD linked oxidase domain protein
L1857_01025	COG0586	Pfam SNARE associated Golgi protein
L1857_01060	COG0300	oxidoreductase activity
L1857_01065	COG0667	Aldo Keto reductase
L1857_01105	COG4172	Belongs to the ABC transporter superfamily
L1857_01110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_01115	COG0601	transmembrane transport
L1857_01120	COG0747	negative chemotaxis
L1857_01145	COG0025	NhaP-type Na H and K H
L1857_01150	COG5650	phosphatidylinositol metabolic process
L1857_01155	COG0477	Major facilitator Superfamily
L1857_01165	COG0584	glycerophosphoryl diester phosphodiesterase
L1857_01195	COG5280	Phage tail tape measure protein TP901
L1857_01195	COG3953	SLT domain
L1857_01200	COG0436	Aminotransferase
L1857_01235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L1857_01255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_01260	COG1012	belongs to the aldehyde dehydrogenase family
L1857_01265	COG1376	ErfK ybiS ycfS ynhG family protein
L1857_01300	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1857_01305	COG0047	phosphoribosylformylglycinamidine synthase activity
L1857_01310	COG1132	(ABC) transporter
L1857_01315	COG1132	(ABC) transporter
L1857_01320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1857_01395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L1857_01400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L1857_01440	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_01460	COG1984	allophanate hydrolase subunit 2
L1857_01470	COG4044	May play a role in the intracellular transport of hydrophobic ligands
L1857_01500	COG0745	RESPONSE REGULATOR receiver
L1857_01505	COG0454	-acetyltransferase
L1857_01505	COG0456	acetyltransferase
L1857_01525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1857_01545	COG2357	RelA SpoT domain protein
L1857_01550	COG0704	Plays a role in the regulation of phosphate uptake
L1857_01570	COG1525	nuclease
L1857_01570	COG4085	toxin activity
L1857_01570	COG0737	Belongs to the 5'-nucleotidase family
L1857_01585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L1857_01600	COG2197	response regulator
L1857_01605	COG1960	acyl-CoA dehydrogenase activity
L1857_01640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L1857_01680	COG3030	protein affecting phage T7 exclusion by the F plasmid
L1857_01690	COG1309	transcriptional regulator
L1857_01695	COG2030	dehydratase
L1857_01700	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_01705	COG0183	Belongs to the thiolase family
L1857_01720	COG1733	regulation of RNA biosynthetic process
L1857_01785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L1857_01800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L1857_01810	COG4585	Histidine kinase
L1857_01815	COG2197	response regulator
L1857_01850	COG1136	(ABC) transporter
L1857_01860	COG2197	response regulator
L1857_01880	COG0402	S-adenosylhomocysteine deaminase activity
L1857_01885	COG0702	epimerase
L1857_01890	COG1309	transcriptional regulator
L1857_01910	COG4221	oxidoreductase activity
L1857_01930	COG2814	Major facilitator Superfamily
L1857_01935	COG1846	Transcriptional regulator
L1857_01945	COG0640	Transcriptional regulator
L1857_01950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1857_01970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1857_02000	COG0360	Binds together with S18 to 16S ribosomal RNA
L1857_02010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L1857_02015	COG0359	binds to the 23S rRNA
L1857_02045	COG0789	Transcriptional regulator
L1857_02055	COG2267	carboxylic ester hydrolase activity
L1857_02075	COG3384	dioxygenase
L1857_02110	COG2205	protein histidine kinase activity
L1857_02115	COG2197	response regulator
L1857_02125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1857_02130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_02140	COG0495	leucyl-tRNA aminoacylation
L1857_02155	COG1678	Uncharacterized ACR, COG1678
L1857_02210	COG4585	Histidine kinase
L1857_02215	COG0617	tRNA 3'-terminal CCA addition
L1857_02240	COG1595	DNA-templated transcription, initiation
L1857_02255	COG3118	belongs to the thioredoxin family
L1857_02255	COG0492	ferredoxin-NADP+ reductase activity
L1857_02260	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1857_02260	COG3409	Peptidoglycan-binding domain 1 protein
L1857_02275	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1857_02285	COG1192	Involved in chromosome partitioning
L1857_02290	COG0357	Ribosomal RNA small subunit methyltransferase G
L1857_02305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L1857_02325	COG0583	DNA-binding transcription factor activity
L1857_02335	COG0592	DNA-directed DNA polymerase activity
L1857_02340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L1857_02345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1857_02350	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
L1857_02355	COG0187	DNA topoisomerase II activity
L1857_02360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1857_02505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1857_02520	COG2353	YceI-like domain
L1857_02580	COG0457	Tetratricopeptide repeat
L1857_02580	COG0705	Rhomboid family
L1857_02595	COG3764	Sortase (surface protein transpeptidase)
L1857_02635	COG0745	RESPONSE REGULATOR receiver
L1857_02640	COG2205	protein histidine kinase activity
L1857_02660	COG0768	penicillin binding
L1857_02675	COG1716	ATPase activity
L1857_02680	COG1716	ATPase activity
L1857_02705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1857_02710	COG0583	DNA-binding transcription factor activity
L1857_02770	COG2186	Transcriptional regulator
L1857_02775	COG0747	negative chemotaxis
L1857_02785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_02795	COG4608	Belongs to the ABC transporter superfamily
L1857_02800	COG1012	belongs to the aldehyde dehydrogenase family
L1857_02805	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_02810	COG0154	amidase activity
L1857_02825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1857_02835	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_02840	COG0515	serine threonine protein kinase
L1857_02885	COG2211	Major facilitator Superfamily
L1857_02915	COG1276	copper resistance
L1857_02915	COG2372	response to copper ion
L1857_02930	COG1174	glycine betaine transport
L1857_02940	COG1174	glycine betaine transport
L1857_02975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L1857_02990	COG0477	Major facilitator Superfamily
L1857_03000	COG3209	COG3209 Rhs family protein
L1857_03015	COG4585	Histidine kinase
L1857_03020	COG2197	response regulator
L1857_03035	COG0438	transferase activity, transferring glycosyl groups
L1857_03040	COG4106	trans-aconitate 2-methyltransferase activity
L1857_03080	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_03085	COG0022	dehydrogenase e1 component
L1857_03095	COG0683	leucine binding
L1857_03110	COG1022	Amp-dependent synthetase and ligase
L1857_03120	COG0410	ABC transporter
L1857_03125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_03135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_03140	COG0765	amino acid transport
L1857_03170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_03175	COG3275	phosphorelay sensor kinase activity
L1857_03185	COG3279	Response regulator of the LytR AlgR family
L1857_03195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_03205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_03210	COG0425	Belongs to the sulfur carrier protein TusA family
L1857_03210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1857_03235	COG1191	sigma factor activity
L1857_03245	COG1528	Iron-storage protein
L1857_03290	COG1271	oxidase subunit
L1857_03295	COG1294	oxidase, subunit
L1857_03300	COG4988	ABC transporter
L1857_03330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_03340	COG1846	Transcriptional regulator
L1857_03345	COG1289	transmembrane transporter activity
L1857_03400	COG1072	(Pantothenic acid kinase))
L1857_03405	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L1857_03415	COG0406	alpha-ribazole phosphatase activity
L1857_03430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_03455	COG0754	glutathionylspermidine amidase activity
L1857_03460	COG3766	membrane
L1857_03465	COG0596	Alpha beta hydrolase
L1857_03480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L1857_03485	COG3473	Maleate cis-trans isomerase
L1857_03500	COG0579	oxidoreductase
L1857_03530	COG2207	Transcriptional regulator
L1857_03535	COG2223	nitrite transmembrane transporter activity
L1857_03540	COG0673	inositol 2-dehydrogenase activity
L1857_03545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_03550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1857_03560	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_03595	COG0561	phosphatase activity
L1857_03600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_03615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1857_03635	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_03640	COG0277	FAD linked oxidase domain protein
L1857_03650	COG1216	Glycosyl transferase, family 2
L1857_03660	COG1216	Glycosyl transferase, family 2
L1857_03680	COG2089	acid synthase
L1857_03710	COG1063	alcohol dehydrogenase
L1857_03715	COG2234	aminopeptidase activity
L1857_03750	COG2188	Transcriptional regulator
L1857_03785	COG0443	Heat shock 70 kDa protein
L1857_03815	COG4585	Histidine kinase
L1857_03820	COG2197	response regulator
L1857_03835	COG1522	sequence-specific DNA binding
L1857_03855	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L1857_03885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1857_03895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_03900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L1857_03900	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L1857_03935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_03940	COG2124	cytochrome p450
L1857_03950	COG0477	Major facilitator Superfamily
L1857_03960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_03985	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L1857_03990	COG2814	Major facilitator Superfamily
L1857_03995	COG1309	transcriptional regulator
L1857_04000	COG1937	Protein conserved in bacteria
L1857_04005	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L1857_04020	COG2072	flavoprotein involved in K transport
L1857_04030	COG0028	Belongs to the TPP enzyme family
L1857_04035	COG0248	Ppx GppA phosphatase
L1857_04050	COG2723	6-phospho-beta-galactosidase activity
L1857_04075	COG1309	transcriptional regulator
L1857_04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_04095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_04100	COG1120	ATPase activity
L1857_04105	COG1280	lysine exporter protein (LysE YggA)
L1857_04120	COG3559	Exporter of polyketide antibiotics
L1857_04125	COG1131	(ABC) transporter
L1857_04200	COG0287	Prephenate dehydrogenase
L1857_04205	COG1473	amidohydrolase
L1857_04255	COG1674	ftsk spoiiie
L1857_04275	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L1857_04285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_04300	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_04310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_04315	COG0427	acetyl-CoA hydrolase
L1857_04325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1857_04330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_04335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L1857_04350	COG0444	Belongs to the ABC transporter superfamily
L1857_04355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_04360	COG0601	transmembrane transport
L1857_04365	COG0747	negative chemotaxis
L1857_04385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
L1857_04395	COG1414	Transcriptional regulator
L1857_04400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1857_04415	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_04420	COG0277	FAD linked oxidase domain protein
L1857_04425	COG0247	lactate metabolic process
L1857_04455	COG2200	EAL domain
L1857_04480	COG1472	Belongs to the glycosyl hydrolase 3 family
L1857_04550	COG0542	response to heat
L1857_04555	COG2364	Membrane
L1857_04560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_04580	COG2733	membrane
L1857_04600	COG1136	(ABC) transporter
L1857_04615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1857_04620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L1857_04645	COG1174	glycine betaine transport
L1857_04665	COG2130	NADP-dependent
L1857_04705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L1857_04720	COG0438	transferase activity, transferring glycosyl groups
L1857_04730	COG0588	phosphoglycerate mutase activity
L1857_04740	COG0667	Aldo Keto reductase
L1857_04770	COG0506	proline dehydrogenase activity
L1857_04785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L1857_04820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1857_04835	COG1595	DNA-templated transcription, initiation
L1857_04840	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_04860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L1857_04865	COG0181	hydroxymethylbilane synthase activity
L1857_04870	COG1648	precorrin-2 dehydrogenase activity
L1857_04870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1857_04895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1857_04900	COG0406	alpha-ribazole phosphatase activity
L1857_04915	COG0785	Cytochrome C biogenesis protein
L1857_04925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L1857_04955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L1857_04975	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L1857_04980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L1857_05010	COG0438	transferase activity, transferring glycosyl groups
L1857_05015	COG2226	methyltransferase
L1857_05030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1857_05035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1857_05040	COG0649	NAD binding
L1857_05055	COG1034	ATP synthesis coupled electron transport
L1857_05060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L1857_05065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1857_05070	COG0839	Belongs to the complex I subunit 6 family
L1857_05075	COG0713	ATP synthesis coupled electron transport
L1857_05080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L1857_05105	COG0142	geranyltranstransferase activity
L1857_05115	COG1013	pyruvate-flavodoxin oxidoreductase activity
L1857_05120	COG0674	pyruvate-flavodoxin oxidoreductase activity
L1857_05120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L1857_05130	COG1522	sequence-specific DNA binding
L1857_05135	COG1834	amidinotransferase
L1857_05145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_05165	COG1215	transferase activity, transferring glycosyl groups
L1857_05175	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
L1857_05180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1857_05245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_05250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1857_05260	COG0297	glycogen (starch) synthase activity
L1857_05265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L1857_05290	COG0367	asparagine synthase
L1857_05310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L1857_05315	COG0501	Belongs to the peptidase M48B family
L1857_05325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L1857_05330	COG0596	Alpha beta hydrolase
L1857_05340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L1857_05360	COG1666	GTP binding
L1857_05375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1857_05415	COG2205	protein histidine kinase activity
L1857_05420	COG0745	RESPONSE REGULATOR receiver
L1857_05440	COG1136	(ABC) transporter
L1857_05440	COG0577	efflux transmembrane transporter activity
L1857_05450	COG4941	Belongs to the sigma-70 factor family
L1857_05455	COG1793	dna ligase
L1857_05470	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L1857_05480	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_05485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_05490	COG1021	2,3-dihydroxybenzoate-AMP ligase
L1857_05495	COG0477	Major facilitator Superfamily
L1857_05515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1857_05535	COG0438	transferase activity, transferring glycosyl groups
L1857_05540	COG2814	Major facilitator Superfamily
L1857_05550	COG2197	response regulator
L1857_05555	COG4585	Histidine kinase
L1857_05565	COG2132	Multicopper oxidase
L1857_05580	COG4585	Histidine kinase
L1857_05585	COG0586	Pfam SNARE associated Golgi protein
L1857_05590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L1857_05615	COG2030	dehydratase
L1857_05635	COG2755	lipolytic protein G-D-S-L family
L1857_05640	COG0436	Aminotransferase
L1857_05650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L1857_05665	COG0081	regulation of translation
L1857_05675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L1857_05680	COG0222	ribosome binding
L1857_05695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_05720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L1857_05745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L1857_05770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L1857_05775	COG0049	tRNA binding
L1857_05780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L1857_05790	COG0051	transcription antitermination factor activity, RNA binding
L1857_05795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L1857_05800	COG0088	Forms part of the polypeptide exit tunnel
L1857_05805	COG0089	rRNA binding
L1857_05810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L1857_05815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L1857_05820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L1857_05825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L1857_05835	COG0255	Belongs to the universal ribosomal protein uL29 family
L1857_05840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L1857_05845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L1857_05850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L1857_05855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L1857_05865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L1857_05870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L1857_05880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L1857_05885	COG1841	ribosomal large subunit assembly
L1857_05910	COG0563	adenylate kinase activity
L1857_05920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L1857_05925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L1857_05940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L1857_05945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L1857_05950	COG0202	RNA polymerase activity
L1857_05955	COG0203	ribosomal protein L17
L1857_05960	COG0101	tRNA pseudouridine synthase activity
L1857_05980	COG1404	Belongs to the peptidase S8 family
L1857_05990	COG1674	ftsk spoiiie
L1857_06025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L1857_06035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1857_06060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1857_06075	COG1175	transmembrane transport
L1857_06080	COG0395	ABC-type sugar transport system, permease component
L1857_06085	COG1063	alcohol dehydrogenase
L1857_06090	COG1349	DNA-binding transcription factor activity
L1857_06095	COG1070	Carbohydrate kinase
L1857_06100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L1857_06110	COG0802	atpase or kinase
L1857_06120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L1857_06120	COG0825	malonyl-CoA metabolic process
L1857_06125	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_06135	COG2186	Transcriptional regulator
L1857_06145	COG0456	acetyltransferase
L1857_06150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L1857_06165	COG3540	Alkaline phosphatase
L1857_06170	COG1733	regulation of RNA biosynthetic process
L1857_06180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L1857_06185	COG0459	protein refolding
L1857_06190	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_06195	COG1309	transcriptional regulator
L1857_06240	COG0516	GMP reductase activity
L1857_06270	COG1012	belongs to the aldehyde dehydrogenase family
L1857_06285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L1857_06285	COG0519	Catalyzes the synthesis of GMP from XMP
L1857_06320	COG0583	DNA-binding transcription factor activity
L1857_06330	COG0515	serine threonine protein kinase
L1857_06370	COG0739	heme binding
L1857_06385	COG0045	succinate-CoA ligase (ADP-forming) activity
L1857_06410	COG0138	bifunctional purine biosynthesis protein purh
L1857_06415	COG0667	Aldo Keto reductase
L1857_06435	COG0587	DNA-directed DNA polymerase activity
L1857_06440	COG2816	NAD+ diphosphatase activity
L1857_06455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1857_06465	COG2814	Major facilitator Superfamily
L1857_06505	COG1234	tRNA 3'-trailer cleavage
L1857_06510	COG0708	Exodeoxyribonuclease III
L1857_06525	COG0180	Tryptophanyl-tRNA synthetase
L1857_06530	COG1295	ribonuclease BN
L1857_06535	COG1686	Belongs to the peptidase S11 family
L1857_06560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L1857_06575	COG2009	succinate dehydrogenase
L1857_06580	COG1744	ABC transporter substrate-binding protein PnrA-like
L1857_06595	COG1079	Belongs to the binding-protein-dependent transport system permease family
L1857_06620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L1857_06625	COG2271	Major facilitator Superfamily
L1857_06655	COG2124	cytochrome p450
L1857_06665	COG1063	alcohol dehydrogenase
L1857_06680	COG0395	ABC-type sugar transport system, permease component
L1857_06690	COG2124	cytochrome p450
L1857_06705	COG1012	belongs to the aldehyde dehydrogenase family
L1857_06710	COG1012	belongs to the aldehyde dehydrogenase family
L1857_06715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L1857_06740	COG4106	trans-aconitate 2-methyltransferase activity
L1857_06755	COG0667	Aldo Keto reductase
L1857_06795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1857_06805	COG0515	serine threonine protein kinase
L1857_06830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L1857_06830	COG1473	amidohydrolase
L1857_06860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L1857_06865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1857_06870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L1857_06895	COG4770	biotin carboxylase activity
L1857_06915	COG1301	dicarboxylic acid transport
L1857_06920	COG0424	maF-like protein
L1857_06935	COG1802	Transcriptional regulator
L1857_06950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_06965	COG0640	Transcriptional regulator
L1857_06970	COG3467	pyridoxamine 5'-phosphate
L1857_07015	COG0596	Alpha beta hydrolase
L1857_07035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1857_07040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_07050	COG1388	LysM domain
L1857_07050	COG0791	NLP P60 protein
L1857_07090	COG0483	inositol monophosphate 1-phosphatase activity
L1857_07095	COG0745	RESPONSE REGULATOR receiver
L1857_07105	COG5002	protein histidine kinase activity
L1857_07155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_07160	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_07175	COG2259	Doxx family
L1857_07185	COG1316	TRANSCRIPTIONal
L1857_07190	COG1316	TRANSCRIPTIONal
L1857_07210	COG4221	oxidoreductase activity
L1857_07215	COG0438	transferase activity, transferring glycosyl groups
L1857_07230	COG0438	transferase activity, transferring glycosyl groups
L1857_07265	COG1725	Transcriptional regulator
L1857_07280	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L1857_07290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L1857_07300	COG1309	transcriptional regulator
L1857_07325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_07330	COG1611	Belongs to the LOG family
L1857_07345	COG0463	Glycosyl transferase, family 2
L1857_07360	COG0519	Catalyzes the synthesis of GMP from XMP
L1857_07365	COG1024	Enoyl-CoA hydratase
L1857_07375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L1857_07380	COG0583	DNA-binding transcription factor activity
L1857_07385	COG2814	Major facilitator Superfamily
L1857_07400	COG4122	O-methyltransferase activity
L1857_07415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_07420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1857_07435	COG2239	Acts as a magnesium transporter
L1857_07445	COG0330	HflC and HflK could
L1857_07450	COG1960	acyl-CoA dehydrogenase activity
L1857_07495	COG0598	Magnesium transport protein CorA
L1857_07510	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_07530	COG0613	PHP domain protein
L1857_07535	COG2095	MarC family integral membrane protein
L1857_07555	COG1309	transcriptional regulator
L1857_07560	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_07610	COG2267	carboxylic ester hydrolase activity
L1857_07640	COG2319	Wd-40 repeat
L1857_07650	COG0243	molybdopterin cofactor binding
L1857_07655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_07660	COG2223	nitrite transmembrane transporter activity
L1857_07665	COG2146	nitrite reductase [NAD(P)H] activity
L1857_07665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_07700	COG2378	regulation of single-species biofilm formation
L1857_07730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1857_07760	COG0714	Associated with various cellular activities
L1857_07790	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_07795	COG1309	transcriptional regulator
L1857_07810	COG0612	Peptidase, M16
L1857_07830	COG3265	gluconokinase activity
L1857_07840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L1857_07875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L1857_07925	COG3629	intracellular signal transduction
L1857_07925	COG3903	Transcriptional regulator
L1857_07945	COG3903	Transcriptional regulator
L1857_07945	COG3629	intracellular signal transduction
L1857_07965	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
L1857_07975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L1857_07990	COG1012	belongs to the aldehyde dehydrogenase family
L1857_07995	COG3842	ATPase activity
L1857_08000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L1857_08005	COG1176	ABC-type spermidine putrescine transport system, permease component I
L1857_08010	COG1177	transmembrane transport
L1857_08015	COG1968	undecaprenyl-diphosphatase activity
L1857_08020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L1857_08035	COG2318	DinB family
L1857_08045	COG0653	protein targeting
L1857_08075	COG0174	glutamine synthetase
L1857_08100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L1857_08110	COG0174	glutamine synthetase
L1857_08155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1857_08175	COG3480	Lon protease (S16) C-terminal proteolytic domain
L1857_08185	COG1615	UPF0182 protein
L1857_08220	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L1857_08225	COG2884	Cell division ATP-binding protein ftsE
L1857_08230	COG2177	Part of the ABC transporter FtsEX involved in
L1857_08235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L1857_08265	COG2197	response regulator
L1857_08285	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_08290	COG1414	Transcriptional regulator
L1857_08295	COG2986	histidine ammonia-lyase
L1857_08300	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L1857_08305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_08315	COG1228	amidohydrolase
L1857_08355	COG4585	Histidine kinase
L1857_08360	COG2197	response regulator
L1857_08370	COG1131	(ABC) transporter
L1857_08380	COG1643	Atp-dependent helicase
L1857_08440	COG2801	Transposase and inactivated derivatives
L1857_08465	COG0582	viral genome integration into host DNA
L1857_08575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_08580	COG2816	NAD+ diphosphatase activity
L1857_08595	COG2755	lipolytic protein G-D-S-L family
L1857_08625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1857_08715	COG3328	transposase activity
L1857_08745	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_08755	COG1960	acyl-CoA dehydrogenase activity
L1857_08775	COG1231	oxidoreductase activity
L1857_08795	COG4221	oxidoreductase activity
L1857_08815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1857_08840	COG1595	DNA-templated transcription, initiation
L1857_08850	COG3850	Histidine kinase
L1857_08850	COG3437	response regulator, receiver
L1857_08850	COG2205	protein histidine kinase activity
L1857_08850	COG4999	Histidine kinase
L1857_08855	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_08860	COG0583	DNA-binding transcription factor activity
L1857_08865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L1857_08875	COG0583	DNA-binding transcription factor activity
L1857_08880	COG1119	ATPase activity
L1857_08895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1857_08900	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_08930	COG1228	amidohydrolase
L1857_08970	COG0438	transferase activity, transferring glycosyl groups
L1857_08970	COG1216	Glycosyl transferase, family 2
L1857_08985	COG0477	Major facilitator Superfamily
L1857_08990	COG1309	transcriptional regulator
L1857_08995	COG0187	DNA topoisomerase II activity
L1857_09000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1857_09005	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_09015	COG2208	phosphoserine phosphatase activity
L1857_09020	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_09025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_09030	COG0372	Belongs to the citrate synthase family
L1857_09035	COG0372	Belongs to the citrate synthase family
L1857_09045	COG0583	DNA-binding transcription factor activity
L1857_09055	COG0129	dihydroxy-acid dehydratase activity
L1857_09080	COG4336	lyase activity
L1857_09120	COG4977	sequence-specific DNA binding
L1857_09145	COG3285	dna ligase
L1857_09145	COG1793	dna ligase
L1857_09160	COG1063	alcohol dehydrogenase
L1857_09170	COG1280	lysine exporter protein (LysE YggA)
L1857_09195	COG0564	pseudouridine synthase activity
L1857_09220	COG3226	Transcriptional regulator
L1857_09245	COG2186	Transcriptional regulator
L1857_09295	COG1725	Transcriptional regulator
L1857_09325	COG0018	arginyl-trna synthetase
L1857_09330	COG0019	diaminopimelate decarboxylase activity
L1857_09335	COG0460	homoserine dehydrogenase
L1857_09340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L1857_09345	COG0083	homoserine kinase activity
L1857_09360	COG0254	rRNA binding
L1857_09365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L1857_09370	COG0596	Alpha beta hydrolase
L1857_09375	COG0789	Transcriptional regulator
L1857_09380	COG2890	protein-(glutamine-N5) methyltransferase activity
L1857_09390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L1857_09400	COG0356	it plays a direct role in the translocation of protons across the membrane
L1857_09405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1857_09410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1857_09415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1857_09420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L1857_09425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L1857_09430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L1857_09435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L1857_09460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L1857_09470	COG1280	lysine exporter protein (LysE YggA)
L1857_09475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_09475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_09485	COG0765	amino acid transport
L1857_09490	COG0765	amino acid transport
L1857_09495	COG1126	abc transporter atp-binding protein
L1857_09505	COG1024	Enoyl-CoA hydratase
L1857_09520	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
L1857_09540	COG2376	Dihydroxyacetone kinase
L1857_09570	COG1309	transcriptional regulator
L1857_09595	COG2267	carboxylic ester hydrolase activity
L1857_09610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L1857_09645	COG1335	isochorismatase
L1857_09650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L1857_09655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L1857_09665	COG3191	aminopeptidase activity
L1857_09700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L1857_09705	COG1234	tRNA 3'-trailer cleavage
L1857_09715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L1857_09720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L1857_09725	COG1984	allophanate hydrolase subunit 2
L1857_09730	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L1857_09735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L1857_09770	COG0300	oxidoreductase activity
L1857_09825	COG0110	maltose O-acetyltransferase activity
L1857_09835	COG0431	NADPH-dependent FMN reductase
L1857_09850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L1857_09880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1857_09900	COG1307	EDD domain protein, DegV family
L1857_09910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L1857_09940	COG0482	sulfurtransferase activity
L1857_09975	COG0640	Transcriptional regulator
L1857_10020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_10040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L1857_10070	COG2409	Drug exporters of the RND superfamily
L1857_10080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L1857_10120	COG2259	Doxx family
L1857_10125	COG0129	dihydroxy-acid dehydratase activity
L1857_10130	COG2186	Transcriptional regulator
L1857_10135	COG0154	amidase activity
L1857_10155	COG0440	acetolactate synthase activity
L1857_10160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L1857_10185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_10190	COG1404	Belongs to the peptidase S8 family
L1857_10195	COG0473	3-isopropylmalate dehydrogenase activity
L1857_10200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_10215	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_10225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1857_10280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1857_10285	COG0066	3-isopropylmalate dehydratase activity
L1857_10305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L1857_10320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1857_10345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_10350	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1857_10375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L1857_10380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L1857_10385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L1857_10390	COG1461	Dihydroxyacetone kinase
L1857_10405	COG3800	Transcriptional regulator
L1857_10405	COG1396	sequence-specific DNA binding
L1857_10420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1857_10425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_10430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_10435	COG3973	AAA domain
L1857_10440	COG0742	ribosomal rna small subunit methyltransferase
L1857_10445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L1857_10465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L1857_10470	COG0571	ribonuclease III activity
L1857_10475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_10480	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L1857_10495	COG0367	asparagine synthase
L1857_10505	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L1857_10510	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L1857_10515	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L1857_10540	COG1254	Belongs to the acylphosphatase family
L1857_10560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_10565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L1857_10600	COG1414	Transcriptional regulator
L1857_10605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L1857_10620	COG3835	regulator
L1857_10640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_10650	COG1309	transcriptional regulator
L1857_10660	COG2233	PERMEase
L1857_10685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_10690	COG4266	Belongs to the allantoicase family
L1857_10695	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_10710	COG2873	o-acetylhomoserine
L1857_10720	COG0477	Major facilitator Superfamily
L1857_10745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L1857_10755	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L1857_10800	COG0228	four-way junction DNA binding
L1857_10810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L1857_10815	COG0336	Belongs to the RNA methyltransferase TrmD family
L1857_10820	COG0335	large ribosomal subunit rRNA binding
L1857_10825	COG0681	Belongs to the peptidase S26 family
L1857_10830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L1857_10840	COG0792	nuclease activity
L1857_10865	COG1191	sigma factor activity
L1857_10875	COG0052	Belongs to the universal ribosomal protein uS2 family
L1857_10880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L1857_10885	COG0528	UMP kinase activity
L1857_10890	COG0233	cytoplasmic translational termination
L1857_10905	COG2226	methyltransferase
L1857_10915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L1857_10925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L1857_10930	COG0750	zinc metalloprotease
L1857_10935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L1857_10965	COG2186	Transcriptional regulator
L1857_10970	COG2807	transmembrane transport
L1857_11015	COG0513	Belongs to the DEAD box helicase family
L1857_11025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_11030	COG3022	response to hydroperoxide
L1857_11045	COG3903	Transcriptional regulator
L1857_11045	COG3629	intracellular signal transduction
L1857_11070	COG1609	Transcriptional regulator
L1857_11075	COG2223	nitrite transmembrane transporter activity
L1857_11100	COG2902	Dehydrogenase
L1857_11115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_11125	COG0668	transmembrane transport
L1857_11140	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L1857_11150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L1857_11180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1857_11195	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L1857_11215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_11220	COG1793	dna ligase
L1857_11220	COG3285	dna ligase
L1857_11240	COG1012	belongs to the aldehyde dehydrogenase family
L1857_11260	COG0395	ABC-type sugar transport system, permease component
L1857_11285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L1857_11295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L1857_11300	COG2205	protein histidine kinase activity
L1857_11330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1857_11335	COG0544	peptidyl-prolyl cis-trans isomerase activity
L1857_11340	COG0740	serine-type endopeptidase activity
L1857_11345	COG0740	serine-type endopeptidase activity
L1857_11350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L1857_11365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_11370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L1857_11380	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_11410	COG2353	YceI-like domain
L1857_11415	COG0346	lactoylglutathione lyase activity
L1857_11430	COG0477	Major facilitator Superfamily
L1857_11450	COG0525	valine-tRNA ligase activity
L1857_11455	COG2318	DinB family
L1857_11475	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_11485	COG2755	lipolytic protein G-D-S-L family
L1857_11490	COG1960	acyl-CoA dehydrogenase activity
L1857_11495	COG0154	amidase activity
L1857_11510	COG0285	dihydrofolate synthase activity
L1857_11530	COG0105	UTP biosynthetic process
L1857_11535	COG1414	Transcriptional regulator
L1857_11540	COG1131	(ABC) transporter
L1857_11560	COG1530	ribonuclease E activity
L1857_11560	COG1530	ribonuclease E activity
L1857_11565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L1857_11570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L1857_11575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L1857_11585	COG0477	Major facilitator Superfamily
L1857_11590	COG0514	ATP-dependent DNA helicase (RecQ)
L1857_11595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L1857_11600	COG0799	negative regulation of ribosome biogenesis
L1857_11610	COG2755	lipolytic protein G-D-S-L family
L1857_11615	COG1307	EDD domain protein, DegV family
L1857_11620	COG1596	polysaccharide export
L1857_11620	COG1555	photosystem II stabilization
L1857_11630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L1857_11640	COG0268	Binds directly to 16S ribosomal RNA
L1857_11655	COG2226	methyltransferase
L1857_11685	COG2070	2-Nitropropane dioxygenase
L1857_11700	COG3328	transposase activity
L1857_11730	COG5183	chlorophyll binding
L1857_11730	COG2133	pyrroloquinoline quinone binding
L1857_11750	COG5183	chlorophyll binding
L1857_11750	COG2133	pyrroloquinoline quinone binding
L1857_11795	COG0531	amino acid
L1857_11810	COG0604	alcohol dehydrogenase
L1857_11825	COG2732	(Barnase) inhibitor
L1857_11830	COG1024	Enoyl-CoA hydratase
L1857_11855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_11865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1857_11885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_11925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_11930	COG3104	oligopeptide transport
L1857_11945	COG0477	Major facilitator Superfamily
L1857_11950	COG1309	transcriptional regulator
L1857_11955	COG0367	asparagine synthase
L1857_11960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_11970	COG1053	succinate dehydrogenase
L1857_11970	COG3976	FMN-binding domain protein
L1857_11975	COG0395	ABC-type sugar transport system, permease component
L1857_12015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_12025	COG1953	Uracil, thiamine, allantoin
L1857_12040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1857_12055	COG0484	heat shock protein binding
L1857_12065	COG0537	adenosine 5'-monophosphoramidase activity
L1857_12075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L1857_12090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L1857_12105	COG1381	Involved in DNA repair and RecF pathway recombination
L1857_12110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L1857_12120	COG0701	Predicted permease
L1857_12145	COG0423	glycine-tRNA ligase activity
L1857_12155	COG1396	sequence-specific DNA binding
L1857_12160	COG1131	(ABC) transporter
L1857_12170	COG4585	Histidine kinase
L1857_12175	COG2197	response regulator
L1857_12200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1857_12205	COG0789	Transcriptional regulator
L1857_12215	COG1595	DNA-templated transcription, initiation
L1857_12220	COG0358	DNA primase activity
L1857_12230	COG4106	trans-aconitate 2-methyltransferase activity
L1857_12235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L1857_12255	COG0582	viral genome integration into host DNA
L1857_12330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_12360	COG0410	ABC transporter
L1857_12395	COG3467	pyridoxamine 5'-phosphate
L1857_12415	COG1234	tRNA 3'-trailer cleavage
L1857_12445	COG0124	histidyl-tRNA synthetase
L1857_12460	COG0596	Alpha beta hydrolase
L1857_12465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_12470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1857_12475	COG2080	2 iron, 2 sulfur cluster binding
L1857_12490	COG1802	Transcriptional regulator
L1857_12500	COG1454	alcohol dehydrogenase
L1857_12510	COG0247	lactate metabolic process
L1857_12510	COG0277	FAD linked oxidase domain protein
L1857_12515	COG2318	DinB family
L1857_12525	COG1012	belongs to the aldehyde dehydrogenase family
L1857_12535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_12550	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_12555	COG0183	Belongs to the thiolase family
L1857_12560	COG1960	acyl-CoA dehydrogenase activity
L1857_12565	COG1960	acyl-CoA dehydrogenase activity
L1857_12570	COG1024	Enoyl-CoA hydratase
L1857_12575	COG1024	Enoyl-CoA hydratase
L1857_12580	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_12585	COG1960	acyl-CoA dehydrogenase activity
L1857_12615	COG0009	L-threonylcarbamoyladenylate synthase
L1857_12620	COG4221	oxidoreductase activity
L1857_12635	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_12645	COG1053	succinate dehydrogenase
L1857_12720	COG2186	Transcriptional regulator
L1857_12730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1857_12750	COG1309	transcriptional regulator
L1857_12780	COG4565	transcriptional regulatory protein
L1857_12785	COG3290	protein histidine kinase activity
L1857_12810	COG0702	epimerase
L1857_12820	COG1309	transcriptional regulator
L1857_12825	COG0791	NLP P60 protein
L1857_12830	COG1984	allophanate hydrolase subunit 2
L1857_12840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1857_12865	COG1674	ftsk spoiiie
L1857_12970	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_12975	COG0477	Major facilitator Superfamily
L1857_12980	COG1012	belongs to the aldehyde dehydrogenase family
L1857_12995	COG0747	negative chemotaxis
L1857_13035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_13040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_13085	COG3629	intracellular signal transduction
L1857_13085	COG3903	Transcriptional regulator
L1857_13090	COG3629	intracellular signal transduction
L1857_13090	COG3903	Transcriptional regulator
L1857_13095	COG2197	response regulator
L1857_13100	COG3629	intracellular signal transduction
L1857_13100	COG3903	Transcriptional regulator
L1857_13110	COG0671	phosphoesterase, PA-phosphatase related
L1857_13140	COG1595	DNA-templated transcription, initiation
L1857_13170	COG2011	ABC-type metal ion transport system permease component
L1857_13175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1857_13180	COG1464	Belongs to the NlpA lipoprotein family
L1857_13215	COG1609	Transcriptional regulator
L1857_13220	COG1129	ABC transporter
L1857_13225	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_13230	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_13250	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_13250	COG3347	Dehydrogenase
L1857_13260	COG1070	Carbohydrate kinase
L1857_13265	COG0247	lactate metabolic process
L1857_13270	COG1139	Iron-sulfur cluster binding protein
L1857_13275	COG1556	Lactate utilization protein
L1857_13280	COG2197	response regulator
L1857_13290	COG2132	Multicopper oxidase
L1857_13295	COG2132	Multicopper oxidase
L1857_13355	COG4974	Belongs to the 'phage' integrase family
L1857_13360	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_13370	COG1733	regulation of RNA biosynthetic process
L1857_13385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1857_13395	COG0789	Transcriptional regulator
L1857_13400	COG2814	Major facilitator Superfamily
L1857_13405	COG2814	Major facilitator Superfamily
L1857_13450	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_13460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1857_13465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1857_13470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1857_13480	COG1129	ABC transporter
L1857_13490	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_13500	COG4214	carbohydrate transport
L1857_13510	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_13550	COG2801	Transposase and inactivated derivatives
L1857_13560	COG4829	muconolactone delta-isomerase
L1857_13565	COG3485	protocatechuate 3,4-dioxygenase
L1857_13575	COG0583	DNA-binding transcription factor activity
L1857_13580	COG4638	Rieske (2fe-2S)
L1857_13600	COG2814	Major facilitator Superfamily
L1857_13610	COG3135	benzoate transporter
L1857_13625	COG1793	dna ligase
L1857_13625	COG3285	dna ligase
L1857_13630	COG0477	Major facilitator Superfamily
L1857_13640	COG0028	Belongs to the TPP enzyme family
L1857_13655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_13690	COG1012	belongs to the aldehyde dehydrogenase family
L1857_13705	COG0515	serine threonine protein kinase
L1857_13730	COG0673	inositol 2-dehydrogenase activity
L1857_13745	COG0405	Gamma-glutamyltransferase
L1857_13765	COG1120	ATPase activity
L1857_13775	COG3443	Belongs to the bacterial solute-binding protein 9 family
L1857_13775	COG0803	Belongs to the bacterial solute-binding protein 9 family
L1857_13810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1857_13815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_13820	COG2814	Major facilitator Superfamily
L1857_13850	COG0702	epimerase
L1857_13865	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L1857_13870	COG2218	PFAM glutamate synthase alpha subunit domain protein
L1857_13875	COG0069	glutamate synthase activity
L1857_13890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1857_13895	COG1024	Enoyl-CoA hydratase
L1857_13900	COG0584	glycerophosphoryl diester phosphodiesterase
L1857_13920	COG0477	Major facilitator Superfamily
L1857_13930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1857_13935	COG1012	belongs to the aldehyde dehydrogenase family
L1857_13955	COG0477	Major facilitator Superfamily
L1857_13970	COG2376	Dihydroxyacetone kinase
L1857_13975	COG0698	ribose 5-phosphate isomerase
L1857_13985	COG3959	Transketolase, thiamine diphosphate binding domain
L1857_13990	COG3958	Transketolase
L1857_13995	COG2197	response regulator
L1857_14000	COG0477	Major facilitator Superfamily
L1857_14005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_14010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_14020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_14065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_14070	COG2188	Transcriptional regulator
L1857_14110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_14120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_14125	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_14145	COG2367	Beta-lactamase
L1857_14220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1857_14235	COG0477	Major facilitator Superfamily
L1857_14245	COG2072	flavoprotein involved in K transport
L1857_14255	COG4585	Histidine kinase
L1857_14260	COG2197	response regulator
L1857_14265	COG4152	abc transporter atp-binding protein
L1857_14290	COG1940	carbohydrate kinase activity
L1857_14315	COG3622	Belongs to the hyi family
L1857_14380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_14395	COG1309	transcriptional regulator
L1857_14405	COG0488	(ABC) transporter
L1857_14410	COG3540	Alkaline phosphatase
L1857_14430	COG0604	alcohol dehydrogenase
L1857_14430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1857_14430	COG3321	synthase
L1857_14430	COG4221	oxidoreductase activity
L1857_14435	COG1595	DNA-templated transcription, initiation
L1857_14450	COG0488	(ABC) transporter
L1857_14485	COG0604	alcohol dehydrogenase
L1857_14525	COG2084	Dehydrogenase
L1857_14535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1857_14540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_14570	COG0861	Integral membrane protein TerC family
L1857_14580	COG0477	Major facilitator Superfamily
L1857_14590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1857_14595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1857_14600	COG1609	Transcriptional regulator
L1857_14615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1857_14620	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_14655	COG1454	alcohol dehydrogenase
L1857_14665	COG1012	belongs to the aldehyde dehydrogenase family
L1857_14690	COG0477	Major facilitator Superfamily
L1857_14695	COG0640	Transcriptional regulator
L1857_14715	COG1960	acyl-CoA dehydrogenase activity
L1857_14720	COG1309	transcriptional regulator
L1857_14725	COG0477	Major facilitator Superfamily
L1857_14740	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_14780	COG2814	Major facilitator Superfamily
L1857_14800	COG0745	RESPONSE REGULATOR receiver
L1857_14805	COG5002	protein histidine kinase activity
L1857_14845	COG0646	methionine synthase
L1857_14845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L1857_14855	COG0402	S-adenosylhomocysteine deaminase activity
L1857_14865	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_14915	COG1309	transcriptional regulator
L1857_14955	COG0779	Required for maturation of 30S ribosomal subunits
L1857_14970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L1857_14970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L1857_14980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L1857_14995	COG0300	oxidoreductase activity
L1857_15015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L1857_15030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L1857_15050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L1857_15055	COG1185	polyribonucleotide nucleotidyltransferase activity
L1857_15065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L1857_15080	COG0667	Aldo Keto reductase
L1857_15105	COG3214	Protein conserved in bacteria
L1857_15150	COG0515	serine threonine protein kinase
L1857_15155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_15160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L1857_15190	COG0655	NAD(P)H dehydrogenase (quinone) activity
L1857_15215	COG1674	ftsk spoiiie
L1857_15225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L1857_15230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1857_15240	COG1546	Belongs to the CinA family
L1857_15240	COG1058	Belongs to the CinA family
L1857_15245	COG1396	sequence-specific DNA binding
L1857_15260	COG0167	dihydroorotate dehydrogenase activity
L1857_15280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_15295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1857_15305	COG2814	Major facilitator Superfamily
L1857_15315	COG1609	Transcriptional regulator
L1857_15325	COG0366	Alpha amylase catalytic
L1857_15335	COG1305	Transglutaminase-like
L1857_15345	COG0714	Associated with various cellular activities
L1857_15370	COG2001	Belongs to the MraZ family
L1857_15375	COG0275	rRNA processing
L1857_15385	COG0768	penicillin binding
L1857_15390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L1857_15400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L1857_15405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L1857_15415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L1857_15420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1857_15425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L1857_15455	COG1799	cell septum assembly
L1857_15475	COG0640	Transcriptional regulator
L1857_15480	COG0477	Major facilitator Superfamily
L1857_15485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L1857_15500	COG3263	regulation of cellular component size
L1857_15505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1857_15510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L1857_15540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_15550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_15570	COG0640	Transcriptional regulator
L1857_15590	COG0542	response to heat
L1857_15610	COG0438	transferase activity, transferring glycosyl groups
L1857_15615	COG3546	catalase activity
L1857_15630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1857_15635	COG2192	nodulation
L1857_15645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L1857_15650	COG0859	PFAM glycosyl transferase family 9
L1857_15655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L1857_15660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L1857_15660	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L1857_15670	COG0859	PFAM glycosyl transferase family 9
L1857_15675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L1857_15735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L1857_15750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1857_15755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1857_15785	COG2186	Transcriptional regulator
L1857_15790	COG3386	PFAM SMP-30 Gluconolaconase
L1857_15810	COG1316	TRANSCRIPTIONal
L1857_15830	COG0237	dephospho-CoA kinase activity
L1857_15830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L1857_15845	COG2197	response regulator
L1857_15860	COG1131	(ABC) transporter
L1857_15895	COG1131	(ABC) transporter
L1857_15905	COG1506	peptidase
L1857_15905	COG4946	Tricorn protease homolog
L1857_15905	COG0823	Involved in the tonB-independent uptake of proteins
L1857_15925	COG1129	ABC transporter
L1857_15930	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_15940	COG1609	Transcriptional regulator
L1857_15945	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
L1857_15950	COG1070	Carbohydrate kinase
L1857_15955	COG1285	pathogenesis
L1857_15990	COG0328	RNA-DNA hybrid ribonuclease activity
L1857_16000	COG1864	DNA RNA non-specific endonuclease
L1857_16000	COG3591	Belongs to the peptidase S1B family
L1857_16050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_16070	COG1301	dicarboxylic acid transport
L1857_16075	COG3290	protein histidine kinase activity
L1857_16080	COG4565	transcriptional regulatory protein
L1857_16090	COG2610	gluconate transmembrane transporter activity
L1857_16095	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
L1857_16110	COG0251	oxidation-reduction process
L1857_16125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L1857_16130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L1857_16135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_16140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L1857_16145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1857_16145	COG0072	phenylalanine-tRNA ligase activity
L1857_16170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L1857_16175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L1857_16180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L1857_16185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1857_16190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L1857_16195	COG1438	arginine binding
L1857_16200	COG0165	Argininosuccinate lyase
L1857_16210	COG2094	Belongs to the DNA glycosylase MPG family
L1857_16215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L1857_16240	COG0647	UMP catabolic process
L1857_16255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1857_16285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L1857_16290	COG0504	CTP synthase activity
L1857_16295	COG0494	nUDIX hydrolase
L1857_16315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L1857_16320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L1857_16330	COG0514	ATP-dependent DNA helicase (RecQ)
L1857_16340	COG0475	glutathione-regulated potassium exporter activity
L1857_16360	COG1160	GTP binding
L1857_16380	COG4213	ABC transporter substrate-binding protein
L1857_16390	COG4214	carbohydrate transport
L1857_16405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_16415	COG0747	negative chemotaxis
L1857_16475	COG0583	DNA-binding transcription factor activity
L1857_16485	COG2851	Citrate transporter
L1857_16515	COG0577	efflux transmembrane transporter activity
L1857_16515	COG1136	(ABC) transporter
L1857_16520	COG4591	ABC-type transport system involved in lipoprotein release permease component
L1857_16525	COG2124	cytochrome p450
L1857_16535	COG1414	Transcriptional regulator
L1857_16540	COG0745	RESPONSE REGULATOR receiver
L1857_16550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_16555	COG1116	anion transmembrane transporter activity
L1857_16560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1857_16565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_16570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L1857_16575	COG0506	proline dehydrogenase activity
L1857_16580	COG1012	belongs to the aldehyde dehydrogenase family
L1857_16595	COG1309	transcriptional regulator
L1857_16600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1857_16605	COG3281	Trehalose synthase
L1857_16610	COG0366	Alpha amylase catalytic
L1857_16615	COG0366	Alpha amylase catalytic
L1857_16660	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_16685	COG2843	Capsule synthesis protein
L1857_16700	COG1940	carbohydrate kinase activity
L1857_16710	COG1129	ABC transporter
L1857_16715	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_16720	COG1879	ABC-type sugar transport system periplasmic component
L1857_16735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1857_16765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L1857_16780	COG1268	BioY protein
L1857_16795	COG1122	ATPase activity
L1857_16815	COG0142	geranyltranstransferase activity
L1857_16825	COG4585	Histidine kinase
L1857_16855	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_16855	COG1024	Enoyl-CoA hydratase
L1857_16860	COG1063	alcohol dehydrogenase
L1857_16865	COG1410	methionine synthase
L1857_16865	COG0646	methionine synthase
L1857_16895	COG2115	Belongs to the xylose isomerase family
L1857_16900	COG3842	ATPase activity
L1857_16905	COG1940	carbohydrate kinase activity
L1857_16920	COG0246	Mannitol dehydrogenase
L1857_16925	COG0477	Major facilitator Superfamily
L1857_16930	COG1063	alcohol dehydrogenase
L1857_16940	COG0800	Aldolase
L1857_16960	COG1802	Transcriptional regulator
L1857_16990	COG1595	DNA-templated transcription, initiation
L1857_17025	COG0583	DNA-binding transcription factor activity
L1857_17030	COG1280	lysine exporter protein (LysE YggA)
L1857_17065	COG1414	Transcriptional regulator
L1857_17090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_17125	COG0110	maltose O-acetyltransferase activity
L1857_17140	COG1215	transferase activity, transferring glycosyl groups
L1857_17150	COG0778	Nitroreductase
L1857_17155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L1857_17170	COG1846	Transcriptional regulator
L1857_17180	COG1560	Kdo2-lipid A biosynthetic process
L1857_17185	COG0438	transferase activity, transferring glycosyl groups
L1857_17195	COG3608	succinylglutamate desuccinylase aspartoacylase
L1857_17195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L1857_17210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L1857_17215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L1857_17220	COG0217	transcriptional regulatory protein
L1857_17230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L1857_17235	COG0632	four-way junction helicase activity
L1857_17240	COG2255	four-way junction helicase activity
L1857_17255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L1857_17260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1857_17265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1857_17270	COG1024	Enoyl-CoA hydratase
L1857_17310	COG1653	transport
L1857_17325	COG4977	sequence-specific DNA binding
L1857_17335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1857_17345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L1857_17360	COG2040	homocysteine
L1857_17370	COG2124	cytochrome p450
L1857_17400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L1857_17410	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_17455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_17460	COG1120	ATPase activity
L1857_17475	COG2264	protein methyltransferase activity
L1857_17515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1857_17520	COG1012	belongs to the aldehyde dehydrogenase family
L1857_17525	COG0596	Alpha beta hydrolase
L1857_17540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_17550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_17555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1857_17560	COG3833	ABC-type maltose transport systems, permease component
L1857_17570	COG3842	ATPase activity
L1857_17580	COG1408	metallophosphoesterase
L1857_17590	COG2814	Major facilitator Superfamily
L1857_17610	COG1064	alcohol dehydrogenase
L1857_17620	COG0477	Major facilitator Superfamily
L1857_17705	COG4941	Belongs to the sigma-70 factor family
L1857_17720	COG1309	transcriptional regulator
L1857_17725	COG1511	domain protein
L1857_17740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1857_17745	COG0539	negative regulation of cytoplasmic translation
L1857_17755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1857_17790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_17800	COG2211	Major facilitator Superfamily
L1857_17810	COG0523	cobalamin synthesis protein
L1857_17830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L1857_17840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L1857_17845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L1857_17855	COG1648	precorrin-2 dehydrogenase activity
L1857_17855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1857_17870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_17895	COG1716	ATPase activity
L1857_17950	COG3572	ergothioneine biosynthetic process
L1857_17955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1857_17960	COG0121	glutamine amidotransferase
L1857_17965	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L1857_17995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L1857_18000	COG0492	ferredoxin-NADP+ reductase activity
L1857_18005	COG1309	transcriptional regulator
L1857_18010	COG0183	Belongs to the thiolase family
L1857_18015	COG3104	oligopeptide transport
L1857_18035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L1857_18040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L1857_18050	COG1414	Transcriptional regulator
L1857_18075	COG0110	maltose O-acetyltransferase activity
L1857_18090	COG0640	Transcriptional regulator
L1857_18145	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_18165	COG0513	Belongs to the DEAD box helicase family
L1857_18180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_18190	COG0022	dehydrogenase e1 component
L1857_18195	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_18210	COG2197	response regulator
L1857_18215	COG4585	Histidine kinase
L1857_18240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L1857_18245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L1857_18265	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L1857_18300	COG0477	Major facilitator Superfamily
L1857_18350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L1857_18355	COG0129	dihydroxy-acid dehydratase activity
L1857_18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_18395	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_18400	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_18430	COG0583	DNA-binding transcription factor activity
L1857_18460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_18460	COG2010	Cytochrome c
L1857_18465	COG2080	2 iron, 2 sulfur cluster binding
L1857_18485	COG3226	Transcriptional regulator
L1857_18490	COG2814	Major facilitator Superfamily
L1857_18500	COG1024	Enoyl-CoA hydratase
L1857_18500	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_18515	COG0477	Major facilitator Superfamily
L1857_18525	COG4566	intracellular signal transduction
L1857_18570	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_18580	COG3958	Transketolase
L1857_18585	COG3959	Transketolase, thiamine diphosphate binding domain
L1857_18590	COG1414	Transcriptional regulator
L1857_18595	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_18600	COG1879	ABC-type sugar transport system periplasmic component
L1857_18605	COG1129	ABC transporter
L1857_18610	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_18620	COG2072	flavoprotein involved in K transport
L1857_18655	COG0745	RESPONSE REGULATOR receiver
L1857_18665	COG2205	protein histidine kinase activity
L1857_18675	COG0714	Associated with various cellular activities
L1857_18720	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_18735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1857_18765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1857_18770	COG1674	ftsk spoiiie
L1857_18815	COG2072	flavoprotein involved in K transport
L1857_18820	COG0583	DNA-binding transcription factor activity
L1857_18835	COG2172	sigma factor antagonist activity
L1857_18845	COG1309	transcriptional regulator
L1857_18855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_18860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1857_18865	COG2080	2 iron, 2 sulfur cluster binding
L1857_18870	COG1309	transcriptional regulator
L1857_18895	COG0659	secondary active sulfate transmembrane transporter activity
L1857_18935	COG0673	inositol 2-dehydrogenase activity
L1857_18965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_18985	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_18995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_19005	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L1857_19030	COG2188	Transcriptional regulator
L1857_19035	COG3250	beta-galactosidase activity
L1857_19045	COG1609	Transcriptional regulator
L1857_19055	COG0148	phosphopyruvate hydratase activity
L1857_19065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_19070	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_19100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_19105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_19110	COG0477	Major facilitator Superfamily
L1857_19115	COG0477	Major facilitator Superfamily
L1857_19175	COG1960	acyl-CoA dehydrogenase activity
L1857_19190	COG1278	Cold shock
L1857_19195	COG3328	transposase activity
L1857_19230	COG0659	secondary active sulfate transmembrane transporter activity
L1857_19235	COG3973	AAA domain
L1857_19255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L1857_19275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L1857_19280	COG0789	Transcriptional regulator
L1857_19300	COG1309	transcriptional regulator
L1857_19305	COG3328	transposase activity
L1857_19310	COG1247	-acetyltransferase
L1857_19335	COG0640	Transcriptional regulator
L1857_19365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1857_19370	COG0573	inorganic phosphate transmembrane transporter activity
L1857_19375	COG0581	inorganic phosphate transmembrane transporter activity
L1857_19380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1857_19385	COG0745	RESPONSE REGULATOR receiver
L1857_19390	COG0640	Transcriptional regulator
L1857_19400	COG0798	PFAM Bile acid sodium symporter
L1857_19405	COG2072	flavoprotein involved in K transport
L1857_19410	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_19450	COG0697	spore germination
L1857_19510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1857_19520	COG3209	COG3209 Rhs family protein
L1857_19540	COG1846	Transcriptional regulator
L1857_19550	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L1857_19570	COG2072	flavoprotein involved in K transport
L1857_19605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L1857_19620	COG0431	NADPH-dependent FMN reductase
L1857_19625	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_19635	COG0656	L-ascorbic acid biosynthetic process
L1857_19665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1857_19725	COG0437	4 iron, 4 sulfur cluster binding
L1857_19735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_19755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_19775	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_19790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_19810	COG0667	Aldo Keto reductase
L1857_19815	COG1968	undecaprenyl-diphosphatase activity
L1857_19825	COG0339	signal peptide processing
L1857_19830	COG2226	methyltransferase
L1857_19840	COG0154	amidase activity
L1857_19860	COG1846	Transcriptional regulator
L1857_19885	COG0039	L-malate dehydrogenase activity
L1857_19925	COG0601	transmembrane transport
L1857_19930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_19935	COG4172	Belongs to the ABC transporter superfamily
L1857_19955	COG1619	proteins homologs of microcin C7 resistance protein MccF
L1857_19975	COG1595	DNA-templated transcription, initiation
L1857_20020	COG1733	regulation of RNA biosynthetic process
L1857_20075	COG0477	Major facilitator Superfamily
L1857_20085	COG1595	DNA-templated transcription, initiation
L1857_20115	COG0300	oxidoreductase activity
L1857_20140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_20150	COG0477	Major facilitator Superfamily
L1857_20155	COG1053	succinate dehydrogenase
L1857_20155	COG3976	FMN-binding domain protein
L1857_20160	COG1012	belongs to the aldehyde dehydrogenase family
L1857_20165	COG1802	Transcriptional regulator
L1857_20185	COG2860	membrane
L1857_20210	COG0583	DNA-binding transcription factor activity
L1857_20225	COG2890	protein-(glutamine-N5) methyltransferase activity
L1857_20230	COG1802	Transcriptional regulator
L1857_20280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L1857_20315	COG1435	thymidine kinase activity
L1857_20325	COG0463	Glycosyl transferase, family 2
L1857_20335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L1857_20400	COG4152	abc transporter atp-binding protein
L1857_20460	COG2378	regulation of single-species biofilm formation
L1857_20465	COG2378	regulation of single-species biofilm formation
L1857_20480	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L1857_20485	COG1357	PFAM Pentapeptide repeats (8 copies)
L1857_20490	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L1857_20495	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L1857_20535	COG1222	aaa ATPase
L1857_20555	COG0517	IMP dehydrogenase activity
L1857_20555	COG1994	Peptidase M50
L1857_20570	COG1192	Involved in chromosome partitioning
L1857_20575	COG2814	Major facilitator Superfamily
L1857_20585	COG4941	Belongs to the sigma-70 factor family
L1857_20590	COG3795	YCII-related domain
L1857_20605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L1857_20610	COG0140	phosphoribosyl-ATP diphosphatase activity
L1857_20615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1857_20620	COG1410	methionine synthase
L1857_20620	COG0646	methionine synthase
L1857_20635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L1857_20645	COG0215	cysteine-tRNA ligase activity
L1857_20695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L1857_20700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L1857_20710	COG0477	Major facilitator Superfamily
L1857_20715	COG0745	RESPONSE REGULATOR receiver
L1857_20735	COG2226	methyltransferase
L1857_20740	COG3540	Alkaline phosphatase
L1857_20745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L1857_20755	COG2304	oxidoreductase activity
L1857_20765	COG0714	Associated with various cellular activities
L1857_20780	COG0746	molybdenum cofactor guanylyltransferase activity
L1857_20785	COG0596	Alpha beta hydrolase
L1857_20790	COG0791	NLP P60 protein
L1857_20790	COG3883	PFAM NLP P60 protein
L1857_20805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L1857_20810	COG0477	Major facilitator Superfamily
L1857_20825	COG2197	response regulator
L1857_20860	COG0589	response to stress
L1857_20865	COG2814	Major facilitator Superfamily
L1857_20870	COG1082	Xylose isomerase domain protein TIM barrel
L1857_20875	COG0673	inositol 2-dehydrogenase activity
L1857_20880	COG1082	Xylose isomerase domain protein TIM barrel
L1857_20890	COG3962	Belongs to the TPP enzyme family
L1857_20895	COG3718	enzyme involved in inositol metabolism
L1857_20905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_20910	COG1609	Transcriptional regulator
L1857_20925	COG0714	Associated with various cellular activities
L1857_20935	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L1857_20940	COG0137	argininosuccinate synthase activity
L1857_20970	COG1802	Transcriptional regulator
L1857_20980	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
L1857_20985	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_21000	COG1414	Transcriptional regulator
L1857_21005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_21010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_21015	COG2610	gluconate transmembrane transporter activity
L1857_21025	COG3655	Transcriptional regulator
L1857_21030	COG2814	Major facilitator Superfamily
L1857_21085	COG2226	methyltransferase
L1857_21105	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1857_21105	COG5479	isomerase activity
L1857_21120	COG4941	Belongs to the sigma-70 factor family
L1857_21140	COG0640	Transcriptional regulator
L1857_21160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L1857_21175	COG1309	transcriptional regulator
L1857_21180	COG2267	carboxylic ester hydrolase activity
L1857_21185	COG2755	lipolytic protein G-D-S-L family
L1857_21195	COG1733	regulation of RNA biosynthetic process
L1857_21205	COG2814	Major facilitator Superfamily
L1857_21220	COG0251	oxidation-reduction process
L1857_21255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1857_21290	COG1846	Transcriptional regulator
L1857_21300	COG0477	Major facilitator Superfamily
L1857_21305	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_21330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_21335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L1857_21345	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_21355	COG3250	beta-galactosidase activity
L1857_21360	COG1609	Transcriptional regulator
L1857_21365	COG1904	glucuronate isomerase
L1857_21370	COG0246	Mannitol dehydrogenase
L1857_21430	COG0596	Alpha beta hydrolase
L1857_21435	COG1335	isochorismatase
L1857_21460	COG0477	Major facilitator Superfamily
L1857_21475	COG2309	aminopeptidase activity
L1857_21485	COG1280	lysine exporter protein (LysE YggA)
L1857_21495	COG0596	Alpha beta hydrolase
L1857_21505	COG0697	spore germination
L1857_21510	COG0583	DNA-binding transcription factor activity
L1857_21545	COG5280	Phage tail tape measure protein TP901
L1857_21545	COG3953	SLT domain
L1857_21565	COG0596	Alpha beta hydrolase
L1857_21600	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_21605	COG1024	Enoyl-CoA hydratase
L1857_21610	COG1960	acyl-CoA dehydrogenase activity
L1857_21620	COG1309	transcriptional regulator
L1857_21625	COG1739	Uncharacterized protein family UPF0029
L1857_21630	COG0009	L-threonylcarbamoyladenylate synthase
L1857_21665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_21675	COG0477	Major facilitator Superfamily
L1857_21680	COG1802	Transcriptional regulator
L1857_21690	COG1937	Protein conserved in bacteria
L1857_21720	COG0583	DNA-binding transcription factor activity
L1857_21725	COG1942	4-Oxalocrotonate Tautomerase
L1857_21730	COG2855	membrane
L1857_21745	COG0280	phosphate acetyltransferase
L1857_21755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_21770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_21785	COG1414	Transcriptional regulator
L1857_21795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_21800	COG1113	amino acid transport
L1857_21830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L1857_21835	COG0569	domain protein
L1857_21840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1857_21890	COG0025	NhaP-type Na H and K H
L1857_21895	COG1063	alcohol dehydrogenase
L1857_21900	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_21905	COG3387	PFAM Glycoside hydrolase 15-related
L1857_21915	COG1295	ribonuclease BN
L1857_21940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1857_21970	COG1957	nucleoside hydrolase
L1857_22010	COG0740	serine-type endopeptidase activity
L1857_22015	COG1012	belongs to the aldehyde dehydrogenase family
L1857_22035	COG1846	Transcriptional regulator
L1857_22070	COG0477	Major facilitator Superfamily
L1857_22075	COG3971	2-oxopent-4-enoate hydratase activity
L1857_22085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_22085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_22100	COG1012	belongs to the aldehyde dehydrogenase family
L1857_22105	COG1309	transcriptional regulator
L1857_22110	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_22115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L1857_22115	COG1042	CoA-binding domain protein
L1857_22115	COG0045	succinate-CoA ligase (ADP-forming) activity
L1857_22120	COG1960	acyl-CoA dehydrogenase activity
L1857_22130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L1857_22160	COG2197	response regulator
L1857_22165	COG4585	Histidine kinase
L1857_22180	COG1012	belongs to the aldehyde dehydrogenase family
L1857_22200	COG3835	regulator
L1857_22210	COG4266	Belongs to the allantoicase family
L1857_22215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_22220	COG1929	Belongs to the glycerate kinase type-1 family
L1857_22225	COG3960	tartronate-semialdehyde synthase activity
L1857_22230	COG2084	Dehydrogenase
L1857_22235	COG3622	Belongs to the hyi family
L1857_22245	COG2252	PERMEase
L1857_22250	COG0590	tRNA wobble adenosine to inosine editing
L1857_22255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_22275	COG2351	hydroxyisourate hydrolase activity
L1857_22285	COG3835	regulator
L1857_22315	COG0189	ligase activity
L1857_22370	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_22375	COG4221	oxidoreductase activity
L1857_22420	COG1846	Transcriptional regulator
L1857_22445	COG0492	ferredoxin-NADP+ reductase activity
L1857_22450	COG1247	-acetyltransferase
L1857_22455	COG0477	Major facilitator Superfamily
L1857_22475	COG1414	Transcriptional regulator
L1857_22480	COG2814	Major facilitator Superfamily
L1857_22505	COG3485	protocatechuate 3,4-dioxygenase
L1857_22510	COG1454	alcohol dehydrogenase
L1857_22515	COG2814	Major facilitator Superfamily
L1857_22525	COG0596	Alpha beta hydrolase
L1857_22555	COG0640	Transcriptional regulator
L1857_22585	COG1136	(ABC) transporter
L1857_22595	COG4585	Histidine kinase
L1857_22600	COG2197	response regulator
L1857_22625	COG0022	dehydrogenase e1 component
L1857_22630	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_22640	COG1846	Transcriptional regulator
L1857_22640	COG1940	carbohydrate kinase activity
L1857_22650	COG0183	Belongs to the thiolase family
L1857_22665	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_22670	COG1960	acyl-CoA dehydrogenase activity
L1857_22685	COG0280	phosphate acetyltransferase
L1857_22700	COG5416	Lipopolysaccharide assembly protein A domain
L1857_22730	COG1302	Protein conserved in bacteria
L1857_22750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_22770	COG0596	Alpha beta hydrolase
L1857_22785	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
L1857_22790	COG1309	transcriptional regulator
L1857_22820	COG1063	alcohol dehydrogenase
L1857_22840	COG2318	DinB family
L1857_22845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L1857_22845	COG1796	DNA polymerase
L1857_22850	COG4941	Belongs to the sigma-70 factor family
L1857_22875	COG2259	Doxx family
L1857_22885	COG3209	COG3209 Rhs family protein
L1857_22915	COG5650	phosphatidylinositol metabolic process
L1857_22920	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L1857_22955	COG1960	acyl-CoA dehydrogenase activity
L1857_22960	COG1960	acyl-CoA dehydrogenase activity
L1857_22965	COG1960	acyl-CoA dehydrogenase activity
L1857_22970	COG1309	transcriptional regulator
L1857_22980	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_22985	COG1309	transcriptional regulator
L1857_22990	COG0596	Alpha beta hydrolase
L1857_23020	COG1309	transcriptional regulator
L1857_23040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_23045	COG1960	acyl-CoA dehydrogenase activity
L1857_23060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L1857_23060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_23065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_23095	COG0657	acetylesterase activity
L1857_23110	COG1316	TRANSCRIPTIONal
L1857_23120	COG4821	SIS domain
L1857_23125	COG1132	(ABC) transporter
L1857_23140	COG0488	(ABC) transporter
L1857_23145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L1857_23150	COG3706	GGDEF domain
L1857_23150	COG5001	Diguanylate cyclase
L1857_23150	COG2203	Gaf domain
L1857_23150	COG4251	negative regulation of phosphorylation
L1857_23160	COG2151	metal-sulfur cluster biosynthetic enzyme
L1857_23165	COG0822	iron-sulfur transferase activity
L1857_23175	COG0396	ATPase activity
L1857_23235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_23235	COG3453	Protein conserved in bacteria
L1857_23240	COG2226	methyltransferase
L1857_23260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L1857_23265	COG1657	PFAM Prenyltransferase squalene oxidase
L1857_23275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L1857_23305	COG0697	spore germination
L1857_23310	COG0300	oxidoreductase activity
L1857_23325	COG0109	protoheme IX farnesyltransferase activity
L1857_23335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L1857_23340	COG0166	Belongs to the GPI family
L1857_23355	COG0363	glucosamine-6-phosphate deaminase activity
L1857_23360	COG4585	Histidine kinase
L1857_23375	COG0149	triose-phosphate isomerase activity
L1857_23380	COG0126	phosphoglycerate kinase activity
L1857_23385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L1857_23430	COG1846	Transcriptional regulator
L1857_23455	COG2205	protein histidine kinase activity
L1857_23460	COG0745	RESPONSE REGULATOR receiver
L1857_23470	COG1481	regulation of sporulation
L1857_23480	COG1660	Displays ATPase and GTPase activities
L1857_23485	COG0322	excinuclease ABC activity
L1857_23500	COG0708	Exodeoxyribonuclease III
L1857_23510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L1857_23515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_23515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_23540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L1857_23545	COG0405	Gamma-glutamyltransferase
L1857_23555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L1857_23565	COG1758	RNA polymerase activity
L1857_23570	COG0194	GDP metabolic process
L1857_23580	COG0284	orotidine-5'-phosphate decarboxylase activity
L1857_23590	COG0505	Belongs to the CarA family
L1857_23605	COG0540	Belongs to the ATCase OTCase family
L1857_23610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L1857_23620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1857_23625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1857_23645	COG0346	lactoylglutathione lyase activity
L1857_23655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L1857_23660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L1857_23665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1857_23670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L1857_23710	COG2190	(PTS) system
L1857_23715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1857_23720	COG2188	Transcriptional regulator
L1857_23725	COG1263	PTS System
L1857_23730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1857_23755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L1857_23810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L1857_23825	COG1733	regulation of RNA biosynthetic process
L1857_23835	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
L1857_23855	COG0702	epimerase
L1857_23860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_23875	COG0386	Belongs to the glutathione peroxidase family
L1857_23895	COG1252	NADH dehydrogenase
L1857_23900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1857_23910	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
L1857_23915	COG1473	amidohydrolase
L1857_23945	COG1414	Transcriptional regulator
L1857_23975	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_24005	COG2018	Roadblock/LC7 domain
L1857_24050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_24055	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_24080	COG2197	response regulator
L1857_24100	COG0439	Biotin carboxylase
L1857_24105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_24115	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_24125	COG2814	Major facilitator Superfamily
L1857_24150	COG0477	Major facilitator Superfamily
L1857_24155	COG0583	DNA-binding transcription factor activity
L1857_24160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1857_24165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L1857_24170	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_24175	COG1960	acyl-CoA dehydrogenase activity
L1857_24205	COG1278	Cold shock
L1857_24210	COG1940	carbohydrate kinase activity
L1857_24215	COG0673	inositol 2-dehydrogenase activity
L1857_24240	COG0590	tRNA wobble adenosine to inosine editing
L1857_24250	COG1522	sequence-specific DNA binding
L1857_24275	COG1960	acyl-CoA dehydrogenase activity
L1857_24290	COG1802	Transcriptional regulator
L1857_24315	COG2376	Dihydroxyacetone kinase
L1857_24320	COG1414	Transcriptional regulator
L1857_24335	COG2197	response regulator
L1857_24365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_24395	COG0542	response to heat
L1857_24415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_24430	COG2226	methyltransferase
L1857_24450	COG0640	Transcriptional regulator
L1857_24455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1857_24505	COG1316	TRANSCRIPTIONal
L1857_24530	COG2175	clavaminate synthase activity
L1857_24535	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
L1857_24540	COG3336	cytochrome c oxidase
L1857_24560	COG2318	DinB family
L1857_24565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1857_24570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_24575	COG0765	amino acid transport
L1857_24650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_24665	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_24685	COG2272	Belongs to the type-B carboxylesterase lipase family
L1857_24715	COG4941	Belongs to the sigma-70 factor family
L1857_24720	COG3795	YCII-related domain
L1857_24750	COG3546	catalase activity
L1857_24755	COG4946	Tricorn protease homolog
L1857_24755	COG1506	peptidase
L1857_24755	COG0823	Involved in the tonB-independent uptake of proteins
L1857_24780	COG0697	spore germination
L1857_24785	COG0463	Glycosyl transferase, family 2
L1857_24820	COG1309	transcriptional regulator
L1857_24830	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_24865	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_24870	COG3622	Belongs to the hyi family
L1857_24875	COG1846	Transcriptional regulator
L1857_24880	COG0477	Major facilitator Superfamily
L1857_24885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_24895	COG2018	Roadblock/LC7 domain
L1857_24910	COG3033	Beta-eliminating lyase
L1857_24920	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_24925	COG1024	Enoyl-CoA hydratase
L1857_24930	COG0577	efflux transmembrane transporter activity
L1857_24930	COG1136	(ABC) transporter
L1857_24935	COG0577	efflux transmembrane transporter activity
L1857_24935	COG1136	(ABC) transporter
L1857_24955	COG0745	RESPONSE REGULATOR receiver
L1857_24960	COG2205	protein histidine kinase activity
L1857_24965	COG3012	SEC-C Motif Domain Protein
L1857_24980	COG0183	Belongs to the thiolase family
L1857_25000	COG2271	Major facilitator Superfamily
L1857_25005	COG0583	DNA-binding transcription factor activity
L1857_25015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_25030	COG3386	PFAM SMP-30 Gluconolaconase
L1857_25090	COG3835	regulator
L1857_25105	COG2271	Major facilitator Superfamily
L1857_25115	COG0657	acetylesterase activity
L1857_25120	COG1414	Transcriptional regulator
L1857_25125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_25130	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_25150	COG1414	Transcriptional regulator
L1857_25155	COG2814	Major facilitator Superfamily
L1857_25165	COG3250	beta-galactosidase activity
L1857_25170	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_25195	COG0673	inositol 2-dehydrogenase activity
L1857_25200	COG1063	alcohol dehydrogenase
L1857_25210	COG1136	(ABC) transporter
L1857_25215	COG0577	efflux transmembrane transporter activity
L1857_25215	COG1136	(ABC) transporter
L1857_25235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_25240	COG0765	amino acid transport
L1857_25245	COG0765	amino acid transport
L1857_25250	COG1126	abc transporter atp-binding protein
L1857_25270	COG2267	carboxylic ester hydrolase activity
L1857_25290	COG0640	Transcriptional regulator
L1857_25295	COG0798	PFAM Bile acid sodium symporter
L1857_25300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1857_25335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_25335	COG0426	domain, Protein
L1857_25340	COG1960	acyl-CoA dehydrogenase activity
L1857_25345	COG1960	acyl-CoA dehydrogenase activity
L1857_25350	COG1960	acyl-CoA dehydrogenase activity
L1857_25355	COG1024	Enoyl-CoA hydratase
L1857_25360	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_25365	COG1960	acyl-CoA dehydrogenase activity
L1857_25375	COG0183	Belongs to the thiolase family
L1857_25395	COG1024	Enoyl-CoA hydratase
L1857_25400	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_25415	COG0640	Transcriptional regulator
L1857_25420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1857_25430	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_25430	COG1024	Enoyl-CoA hydratase
L1857_25480	COG2375	cellular response to nickel ion
L1857_25480	COG1132	(ABC) transporter
L1857_25485	COG1132	(ABC) transporter
L1857_25490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1857_25495	COG4638	Rieske (2fe-2S)
L1857_25500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1857_25535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1857_25540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1857_25550	COG1760	l-serine dehydratase
L1857_25560	COG1414	Transcriptional regulator
L1857_25565	COG2146	nitrite reductase [NAD(P)H] activity
L1857_25575	COG3226	Transcriptional regulator
L1857_25580	COG1012	belongs to the aldehyde dehydrogenase family
L1857_25605	COG4977	sequence-specific DNA binding
L1857_25610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L1857_25615	COG1012	belongs to the aldehyde dehydrogenase family
L1857_25630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L1857_25650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1857_25650	COG0574	Belongs to the PEP-utilizing enzyme family
L1857_25730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_25750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_25760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_25820	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_25830	COG0154	amidase activity
L1857_25855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_25860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1857_25865	COG1012	belongs to the aldehyde dehydrogenase family
L1857_25875	COG1735	metal-dependent hydrolase with the TIM-barrel fold
L1857_25885	COG2124	cytochrome p450
L1857_25920	COG0596	Alpha beta hydrolase
L1857_25945	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_25955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_25960	COG4176	ABC-type proline glycine betaine transport system permease component
L1857_25965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L1857_25975	COG0066	3-isopropylmalate dehydratase activity
L1857_25980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1857_25985	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L1857_25990	COG1414	Transcriptional regulator
L1857_25995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_26000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1857_26055	COG0791	NLP P60 protein
L1857_26055	COG3883	PFAM NLP P60 protein
L1857_26120	COG0714	Associated with various cellular activities
L1857_26285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_26285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_26340	COG4977	sequence-specific DNA binding
L1857_26350	COG0174	glutamine synthetase
L1857_26380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1857_26395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L1857_26405	COG1793	dna ligase
L1857_26425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_26440	COG0515	serine threonine protein kinase
L1857_26470	COG3220	belongs to the UPF0276 family
L1857_26485	COG3253	May function as heme-dependent peroxidase
L1857_26495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L1857_26505	COG2197	response regulator
L1857_26515	COG0183	Belongs to the thiolase family
L1857_26520	COG1024	Enoyl-CoA hydratase
L1857_26520	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_26525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_26530	COG1846	Transcriptional regulator
L1857_26535	COG0656	L-ascorbic acid biosynthetic process
L1857_26540	COG2205	protein histidine kinase activity
L1857_26545	COG0745	RESPONSE REGULATOR receiver
L1857_26550	COG0583	DNA-binding transcription factor activity
L1857_26560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L1857_26575	COG1053	succinate dehydrogenase
L1857_26580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L1857_26590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1857_26595	COG0531	amino acid
L1857_26600	COG0569	domain protein
L1857_26610	COG0596	Alpha beta hydrolase
L1857_26645	COG0756	dUTP diphosphatase activity
L1857_26665	COG0483	inositol monophosphate 1-phosphatase activity
L1857_26685	COG0531	amino acid
L1857_26695	COG0174	glutamine synthetase
L1857_26730	COG2313	pseudouridylate synthase activity
L1857_26745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_26750	COG2318	DinB family
L1857_26765	COG1490	D-aminoacyl-tRNA deacylase activity
L1857_26790	COG3795	YCII-related domain
L1857_26795	COG4941	Belongs to the sigma-70 factor family
L1857_26810	COG2070	2-Nitropropane dioxygenase
L1857_26850	COG2124	cytochrome p450
L1857_26855	COG0183	Belongs to the thiolase family
L1857_26865	COG2226	methyltransferase
L1857_26875	COG0583	DNA-binding transcription factor activity
L1857_26880	COG1733	regulation of RNA biosynthetic process
L1857_26885	COG0702	epimerase
L1857_26900	COG1473	amidohydrolase
L1857_26910	COG0596	Alpha beta hydrolase
L1857_26930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L1857_26935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_26945	COG0366	Alpha amylase catalytic
L1857_26950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_26955	COG0346	lactoylglutathione lyase activity
L1857_26960	COG2267	carboxylic ester hydrolase activity
L1857_26965	COG1960	acyl-CoA dehydrogenase activity
L1857_26975	COG1053	succinate dehydrogenase
L1857_26995	COG2030	dehydratase
L1857_27020	COG1960	acyl-CoA dehydrogenase activity
L1857_27025	COG1960	acyl-CoA dehydrogenase activity
L1857_27030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1857_27035	COG0657	acetylesterase activity
L1857_27045	COG1733	regulation of RNA biosynthetic process
L1857_27050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L1857_27055	COG1960	acyl-CoA dehydrogenase activity
L1857_27060	COG1309	transcriptional regulator
L1857_27080	COG1703	isobutyryl-CoA mutase activity
L1857_27080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_27080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_27095	COG2018	Roadblock/LC7 domain
L1857_27110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_27115	COG0019	diaminopimelate decarboxylase activity
L1857_27120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L1857_27135	COG1566	PFAM secretion protein HlyD family protein
L1857_27155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_27170	COG1012	belongs to the aldehyde dehydrogenase family
L1857_27175	COG1672	PFAM Archaeal ATPase
L1857_27175	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L1857_27200	COG1946	Acyl-CoA thioesterase
L1857_27225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1857_27235	COG0204	Acyl-transferase
L1857_27250	COG1929	Belongs to the glycerate kinase type-1 family
L1857_27255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_27265	COG1309	transcriptional regulator
L1857_27280	COG2890	protein-(glutamine-N5) methyltransferase activity
L1857_27300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L1857_27305	COG0723	plastoquinol--plastocyanin reductase activity
L1857_27310	COG3328	transposase activity
L1857_27315	COG3328	transposase activity
L1857_27370	COG1278	Cold shock
L1857_27385	COG2080	2 iron, 2 sulfur cluster binding
L1857_27390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_27390	COG2010	Cytochrome c
L1857_27420	COG1902	pentaerythritol trinitrate reductase activity
L1857_27420	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_27425	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_27425	COG1902	pentaerythritol trinitrate reductase activity
L1857_27435	COG0535	radical SAM domain protein
L1857_27470	COG1940	carbohydrate kinase activity
L1857_27480	COG0003	Pfam Anion-transporting ATPase
L1857_27500	COG1022	Amp-dependent synthetase and ligase
L1857_27555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_27560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_27570	COG1012	belongs to the aldehyde dehydrogenase family
L1857_27575	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_27585	COG1960	acyl-CoA dehydrogenase activity
L1857_27590	COG1960	acyl-CoA dehydrogenase activity
L1857_27595	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_27605	COG0123	including yeast histone deacetylase and acetoin utilization protein
L1857_27615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L1857_27620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L1857_27640	COG0516	GMP reductase activity
L1857_27640	COG0517	IMP dehydrogenase activity
L1857_27655	COG1505	serine-type exopeptidase activity
L1857_27660	COG0477	Major facilitator Superfamily
L1857_27675	COG0758	DNA mediated transformation
L1857_27685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_27690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L1857_27695	COG1388	LysM domain
L1857_27700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L1857_27710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L1857_27725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L1857_27730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L1857_27740	COG1196	nuclear chromosome segregation
L1857_27760	COG2814	Major facilitator Superfamily
L1857_27765	COG0583	DNA-binding transcription factor activity
L1857_27770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1857_27780	COG1126	abc transporter atp-binding protein
L1857_27790	COG0765	amino acid transport
L1857_27795	COG0765	amino acid transport
L1857_27800	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
L1857_27805	COG3842	ATPase activity
L1857_27815	COG1175	transmembrane transport
L1857_27825	COG1940	carbohydrate kinase activity
L1857_27835	COG1053	succinate dehydrogenase
L1857_27855	COG0800	Aldolase
L1857_27865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_27885	COG2137	regulation of response to DNA damage stimulus
L1857_27890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L1857_27900	COG0443	Heat shock 70 kDa protein
L1857_27905	COG1201	RNA secondary structure unwinding
L1857_27910	COG0242	peptide deformylase activity
L1857_27940	COG5504	Zn-dependent protease
L1857_27960	COG0697	spore germination
L1857_27980	COG0583	DNA-binding transcription factor activity
L1857_27990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L1857_27995	COG1396	sequence-specific DNA binding
L1857_28040	COG3328	transposase activity
L1857_28055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_28060	COG0142	geranyltranstransferase activity
L1857_28075	COG2815	serine threonine protein kinase
L1857_28075	COG0515	serine threonine protein kinase
L1857_28095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L1857_28100	COG2409	Drug exporters of the RND superfamily
L1857_28120	COG0067	glutamate synthase
L1857_28120	COG0069	glutamate synthase activity
L1857_28120	COG0070	glutamate synthase
L1857_28130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_28135	COG1120	ATPase activity
L1857_28165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L1857_28185	COG0159	tryptophan synthase activity
L1857_28190	COG0133	tryptophan synthase activity
L1857_28195	COG0134	indole-3-glycerol-phosphate synthase activity
L1857_28205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L1857_28215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L1857_28220	COG0107	imidazoleglycerol-phosphate synthase activity
L1857_28235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L1857_28240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L1857_28250	COG3958	Transketolase
L1857_28255	COG3959	Transketolase, thiamine diphosphate binding domain
L1857_28270	COG0456	acetyltransferase
L1857_28275	COG1309	transcriptional regulator
L1857_28280	COG2409	Drug exporters of the RND superfamily
L1857_28290	COG0131	Imidazoleglycerol-phosphate dehydratase
L1857_28295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1857_28300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1857_28315	COG2197	response regulator
L1857_28330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_28330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_28345	COG0157	Belongs to the NadC ModD family
L1857_28350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L1857_28380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L1857_28390	COG0789	Transcriptional regulator
L1857_28400	COG2124	cytochrome p450
L1857_28415	COG0438	transferase activity, transferring glycosyl groups
L1857_28420	COG0791	NLP P60 protein
L1857_28455	COG2010	Cytochrome c
L1857_28460	COG1845	cytochrome c oxidase, subunit III
L1857_28475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L1857_28485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L1857_28495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_28515	COG0667	Aldo Keto reductase
L1857_28535	COG1228	amidohydrolase
L1857_28540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L1857_28575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1857_28580	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_28595	COG1090	epimerase
L1857_28605	COG0321	lipoyl(octanoyl) transferase activity
L1857_28630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L1857_28635	COG0586	Pfam SNARE associated Golgi protein
L1857_28650	COG1752	Esterase of the alpha-beta hydrolase superfamily
L1857_28655	COG1376	ErfK ybiS ycfS ynhG family protein
L1857_28660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1857_28670	COG0587	DNA-directed DNA polymerase activity
L1857_28690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1857_28705	COG1136	(ABC) transporter
L1857_28705	COG0577	efflux transmembrane transporter activity
L1857_28710	COG4585	Histidine kinase
L1857_28715	COG2197	response regulator
L1857_28720	COG1472	Belongs to the glycosyl hydrolase 3 family
L1857_28730	COG1653	transport
L1857_28735	COG1175	transmembrane transport
L1857_28765	COG1397	ADP-ribosylglycohydrolase
L1857_28795	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L1857_28810	COG1620	l-lactate permease
L1857_28815	COG3201	nicotinamide mononucleotide transporter
L1857_28830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1857_28835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1857_28880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_28885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_28905	COG0442	prolyl-tRNA aminoacylation
L1857_28915	COG1414	Transcriptional regulator
L1857_28935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L1857_28955	COG2186	Transcriptional regulator
L1857_28960	COG0028	Belongs to the TPP enzyme family
L1857_28965	COG1742	UPF0060 membrane protein
L1857_28970	COG0859	PFAM glycosyl transferase family 9
L1857_28975	COG1946	Acyl-CoA thioesterase
L1857_29005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1857_29010	COG2151	metal-sulfur cluster biosynthetic enzyme
L1857_29015	COG3396	Phenylacetate-CoA oxygenase
L1857_29020	COG3460	Phenylacetate-CoA oxygenase
L1857_29025	COG3396	Phenylacetate-CoA oxygenase
L1857_29030	COG1012	belongs to the aldehyde dehydrogenase family
L1857_29030	COG2030	dehydratase
L1857_29050	COG1309	transcriptional regulator
L1857_29055	COG2814	Major facilitator Superfamily
L1857_29080	COG1690	Belongs to the RtcB family
L1857_29085	COG1522	sequence-specific DNA binding
L1857_29115	COG2267	carboxylic ester hydrolase activity
L1857_29120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_29125	COG0789	Transcriptional regulator
L1857_29150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_29160	COG1793	dna ligase
L1857_29160	COG3285	dna ligase
L1857_29165	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L1857_29165	COG1672	PFAM Archaeal ATPase
L1857_29170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1857_29180	COG3540	Alkaline phosphatase
L1857_29185	COG4941	Belongs to the sigma-70 factor family
L1857_29200	COG0477	Major facilitator Superfamily
L1857_29210	COG0242	peptide deformylase activity
L1857_29250	COG2315	Protein conserved in bacteria
L1857_29275	COG1846	Transcriptional regulator
L1857_29285	COG0477	Major facilitator Superfamily
L1857_29290	COG0596	Alpha beta hydrolase
L1857_29365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1857_29370	COG1414	Transcriptional regulator
L1857_29375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L1857_29425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_29435	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_29445	COG1506	peptidase
L1857_29445	COG0823	Involved in the tonB-independent uptake of proteins
L1857_29465	COG1733	regulation of RNA biosynthetic process
L1857_29510	COG3275	phosphorelay sensor kinase activity
L1857_29515	COG3279	Response regulator of the LytR AlgR family
L1857_29525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_29535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_29550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_29555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1857_29560	COG2080	2 iron, 2 sulfur cluster binding
L1857_29570	COG2186	Transcriptional regulator
L1857_29575	COG0747	negative chemotaxis
L1857_29595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_29610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L1857_29620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1857_29625	COG0531	amino acid
L1857_29650	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_29670	COG1609	Transcriptional regulator
L1857_29675	COG3328	transposase activity
L1857_29715	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_29725	COG1643	Atp-dependent helicase
L1857_29745	COG0789	Transcriptional regulator
L1857_29745	COG4978	Transcriptional regulator
L1857_29750	COG0475	glutathione-regulated potassium exporter activity
L1857_29760	COG2814	Major facilitator Superfamily
L1857_29785	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_29800	COG1120	ATPase activity
L1857_29805	COG4122	O-methyltransferase activity
L1857_29815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L1857_29820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L1857_29825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1857_29825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1857_29835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1857_29840	COG0174	glutamine synthetase
L1857_29905	COG4106	trans-aconitate 2-methyltransferase activity
L1857_29910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_29925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1857_29930	COG1414	Transcriptional regulator
L1857_29935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1857_29940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_29950	COG3485	protocatechuate 3,4-dioxygenase
L1857_29955	COG3485	protocatechuate 3,4-dioxygenase
L1857_29960	COG0183	Belongs to the thiolase family
L1857_29965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L1857_29970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1857_29990	COG1309	transcriptional regulator
L1857_29995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_30035	COG3268	Saccharopine dehydrogenase
L1857_30065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_30070	COG0583	DNA-binding transcription factor activity
L1857_30095	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
L1857_30100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L1857_30100	COG0235	Class ii aldolase
L1857_30120	COG2197	response regulator
L1857_30125	COG2197	response regulator
L1857_30130	COG0410	ABC transporter
L1857_30135	COG0411	ABC transporter
L1857_30140	COG0559	Belongs to the binding-protein-dependent transport system permease family
L1857_30160	COG0577	efflux transmembrane transporter activity
L1857_30160	COG1136	(ABC) transporter
L1857_30170	COG3971	2-oxopent-4-enoate hydratase activity
L1857_30190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_30195	COG0067	glutamate synthase
L1857_30195	COG0069	glutamate synthase activity
L1857_30195	COG0070	glutamate synthase
L1857_30210	COG1349	DNA-binding transcription factor activity
L1857_30215	COG1492	cobalamin metabolic process
L1857_30220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L1857_30235	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L1857_30255	COG1797	cobyrinic acid a,c-diamide synthase activity
L1857_30290	COG0778	Nitroreductase
L1857_30310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_30315	COG1131	(ABC) transporter
L1857_30325	COG1476	TRANSCRIPTIONal
L1857_30335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L1857_30360	COG2183	response to ionizing radiation
L1857_30380	COG1522	sequence-specific DNA binding
L1857_30390	COG3328	transposase activity
L1857_30400	COG2910	NAD(P)H-binding
L1857_30405	COG0431	NADPH-dependent FMN reductase
L1857_30415	COG3328	transposase activity
L1857_30425	COG0277	FAD linked oxidase domain protein
L1857_30445	COG0515	serine threonine protein kinase
L1857_30445	COG2815	serine threonine protein kinase
L1857_30470	COG1119	ATPase activity
L1857_30505	COG0477	Major facilitator Superfamily
L1857_30520	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_30525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_30535	COG0058	SHG alpha-glucan phosphorylase activity
L1857_30545	COG1846	Transcriptional regulator
L1857_30560	COG2409	Drug exporters of the RND superfamily
L1857_30565	COG2205	protein histidine kinase activity
L1857_30570	COG0745	RESPONSE REGULATOR receiver
L1857_30595	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_30600	COG1879	ABC-type sugar transport system periplasmic component
L1857_30605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L1857_30610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1857_30615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_30625	COG0183	Belongs to the thiolase family
L1857_30660	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L1857_30670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L1857_30690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_30705	COG1376	ErfK ybiS ycfS ynhG family protein
L1857_30780	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_30800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_30805	COG1396	sequence-specific DNA binding
L1857_30870	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L1857_30880	COG1414	Transcriptional regulator
L1857_30895	COG0784	Response regulator, receiver
L1857_30895	COG2205	protein histidine kinase activity
L1857_30915	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_30920	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_30925	COG2172	sigma factor antagonist activity
L1857_30945	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_30975	COG0517	IMP dehydrogenase activity
L1857_31005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L1857_31005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L1857_31025	COG1846	Transcriptional regulator
L1857_31070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L1857_31070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L1857_31100	COG0366	Alpha amylase catalytic
L1857_31135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L1857_31170	COG3844	kynureninase activity
L1857_31185	COG2814	Major facilitator Superfamily
L1857_31205	COG1316	TRANSCRIPTIONal
L1857_31220	COG1309	transcriptional regulator
L1857_31285	COG1595	DNA-templated transcription, initiation
L1857_31295	COG1082	Xylose isomerase domain protein TIM barrel
L1857_31295	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L1857_31300	COG1309	transcriptional regulator
L1857_31305	COG0477	Major facilitator Superfamily
L1857_31330	COG0484	heat shock protein binding
L1857_31340	COG1396	sequence-specific DNA binding
L1857_31340	COG3800	Transcriptional regulator
L1857_31350	COG3340	Belongs to the peptidase S51 family
L1857_31355	COG0242	peptide deformylase activity
L1857_31380	COG1309	transcriptional regulator
L1857_31395	COG0596	Alpha beta hydrolase
L1857_31405	COG0477	Major facilitator Superfamily
L1857_31415	COG0655	NAD(P)H dehydrogenase (quinone) activity
L1857_31420	COG1063	alcohol dehydrogenase
L1857_31430	COG0435	Glutathione S-transferase
L1857_31440	COG0667	Aldo Keto reductase
L1857_31445	COG0154	amidase activity
L1857_31450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_31475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L1857_31480	COG0473	3-isopropylmalate dehydrogenase activity
L1857_31490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L1857_31505	COG0028	Belongs to the TPP enzyme family
L1857_31510	COG1024	Enoyl-CoA hydratase
L1857_31510	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_31515	COG0183	Belongs to the thiolase family
L1857_31520	COG1309	transcriptional regulator
L1857_31535	COG2409	Drug exporters of the RND superfamily
L1857_31540	COG1960	acyl-CoA dehydrogenase activity
L1857_31545	COG1960	acyl-CoA dehydrogenase activity
L1857_31570	COG0640	Transcriptional regulator
L1857_31575	COG0346	lactoylglutathione lyase activity
L1857_31605	COG1960	acyl-CoA dehydrogenase activity
L1857_31615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_31650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_31665	COG2508	Transcriptional regulator
L1857_31665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L1857_31695	COG1132	(ABC) transporter
L1857_31700	COG0277	FAD linked oxidase domain protein
L1857_31710	COG3209	COG3209 Rhs family protein
L1857_31725	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_31725	COG0567	Dehydrogenase, E1 component
L1857_31785	COG0406	alpha-ribazole phosphatase activity
L1857_31790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L1857_31805	COG1597	lipid kinase activity
L1857_31820	COG5662	AntiSigma factor
L1857_31830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L1857_31840	COG2135	peptidase activity
L1857_31860	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L1857_31860	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L1857_31860	COG0506	proline dehydrogenase activity
L1857_31875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_31880	COG1011	Hydrolase
L1857_31890	COG0653	protein targeting
L1857_31895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L1857_31915	COG0477	Major facilitator Superfamily
L1857_31925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_31930	COG5401	PFAM Sporulation and spore germination
L1857_31935	COG5000	phosphorelay sensor kinase activity
L1857_31935	COG5002	protein histidine kinase activity
L1857_31940	COG0745	RESPONSE REGULATOR receiver
L1857_31960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L1857_31970	COG0531	amino acid
L1857_31995	COG1482	cell wall glycoprotein biosynthetic process
L1857_32005	COG2835	tetraacyldisaccharide 4'-kinase activity
L1857_32010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1857_32035	COG1994	Peptidase M50
L1857_32050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_32055	COG0747	negative chemotaxis
L1857_32075	COG4608	Belongs to the ABC transporter superfamily
L1857_32080	COG0747	negative chemotaxis
L1857_32085	COG1217	gtp-binding protein TYPA
L1857_32105	COG0180	Tryptophanyl-tRNA synthetase
L1857_32115	COG2205	protein histidine kinase activity
L1857_32120	COG0745	RESPONSE REGULATOR receiver
L1857_32130	COG1131	(ABC) transporter
L1857_32140	COG3842	ATPase activity
L1857_32145	COG4149	molybdate abc transporter
L1857_32155	COG2154	pterin-4-alpha-carbinolamine dehydratase
L1857_32170	COG0012	GTP binding
L1857_32185	COG0419	ATPase involved in DNA repair
L1857_32195	COG0420	3'-5' exonuclease activity
L1857_32210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L1857_32220	COG1570	exodeoxyribonuclease VII activity
L1857_32230	COG1722	exodeoxyribonuclease VII activity
L1857_32245	COG0492	ferredoxin-NADP+ reductase activity
L1857_32250	COG0114	fumarate hydratase activity
L1857_32255	COG0667	Aldo Keto reductase
L1857_32275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L1857_32285	COG0697	spore germination
L1857_32290	COG1793	dna ligase
L1857_32300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_32305	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_32325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L1857_32350	COG3226	Transcriptional regulator
L1857_32370	COG1331	Highly conserved protein containing a thioredoxin domain
L1857_32385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_32395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1857_32400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_32405	COG1522	sequence-specific DNA binding
L1857_32410	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L1857_32415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1857_32455	COG0183	Belongs to the thiolase family
L1857_32485	COG0642	Histidine kinase
L1857_32505	COG0681	Belongs to the peptidase S26 family
L1857_32525	COG3707	response regulator
L1857_32550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_32560	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_32565	COG0477	Major facilitator Superfamily
L1857_32570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_32580	COG2409	Drug exporters of the RND superfamily
L1857_32625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1857_32635	COG1012	belongs to the aldehyde dehydrogenase family
L1857_32670	COG1252	NADH dehydrogenase
L1857_32720	COG0148	phosphopyruvate hydratase activity
L1857_32740	COG3956	TIGRFAM MazG family protein
L1857_32765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_32785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1857_32790	COG2133	pyrroloquinoline quinone binding
L1857_32795	COG1113	amino acid transport
L1857_32820	COG2076	Multidrug Resistance protein
L1857_32850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1857_32875	COG0193	aminoacyl-tRNA hydrolase activity
L1857_32890	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_32910	COG1309	transcriptional regulator
L1857_32915	COG0488	(ABC) transporter
L1857_32920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L1857_32935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1857_32940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1857_32955	COG0084	hydrolase, TatD family'
L1857_32960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1857_33015	COG0515	serine threonine protein kinase
L1857_33055	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_33075	COG2217	Heavy metal translocating P-type atpase
L1857_33080	COG0640	Transcriptional regulator
L1857_33120	COG0745	RESPONSE REGULATOR receiver
L1857_33125	COG2205	protein histidine kinase activity
L1857_33130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L1857_33135	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L1857_33140	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1857_33175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L1857_33180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1857_33205	COG0315	cyclic pyranopterin monophosphate synthase activity
L1857_33205	COG0521	Mo-molybdopterin cofactor biosynthetic process
L1857_33210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_33220	COG1349	DNA-binding transcription factor activity
L1857_33225	COG2205	protein histidine kinase activity
L1857_33230	COG0745	RESPONSE REGULATOR receiver
L1857_33235	COG2197	response regulator
L1857_33265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1857_33305	COG0387	Pfam Sodium calcium exchanger
L1857_33315	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_33360	COG0668	transmembrane transport
L1857_33365	COG1234	tRNA 3'-trailer cleavage
L1857_33375	COG1012	belongs to the aldehyde dehydrogenase family
L1857_33380	COG3795	YCII-related domain
L1857_33385	COG4941	Belongs to the sigma-70 factor family
L1857_33395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_33410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_33415	COG2267	carboxylic ester hydrolase activity
L1857_33440	COG0583	DNA-binding transcription factor activity
L1857_33445	COG2814	Major facilitator Superfamily
L1857_33450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L1857_33475	COG0583	DNA-binding transcription factor activity
L1857_33480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_33490	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_33495	COG1960	acyl-CoA dehydrogenase activity
L1857_33500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1857_33500	COG5479	isomerase activity
L1857_33510	COG1064	alcohol dehydrogenase
L1857_33515	COG1321	iron dependent repressor
L1857_33545	COG1024	Enoyl-CoA hydratase
L1857_33550	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_33555	COG1309	transcriptional regulator
L1857_33565	COG1960	acyl-CoA dehydrogenase activity
L1857_33575	COG2091	lysine biosynthetic process via aminoadipic acid
L1857_33580	COG1169	isochorismate synthase
L1857_33590	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_33625	COG4152	abc transporter atp-binding protein
L1857_33630	COG1668	transmembrane transport
L1857_33640	COG2801	Transposase and inactivated derivatives
L1857_33645	COG0415	Belongs to the DNA photolyase family
L1857_33660	COG1309	transcriptional regulator
L1857_33670	COG3328	transposase activity
L1857_33695	COG1960	acyl-CoA dehydrogenase activity
L1857_33700	COG1228	amidohydrolase
L1857_33710	COG2017	converts alpha-aldose to the beta-anomer
L1857_33715	COG1309	transcriptional regulator
L1857_33740	COG0259	pyridoxamine-phosphate oxidase activity
L1857_33745	COG0829	nickel cation binding
L1857_33750	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L1857_33760	COG0804	urea catabolic process
L1857_33765	COG0832	Belongs to the urease beta subunit family
L1857_33770	COG0831	urea catabolic process
L1857_33800	COG5650	phosphatidylinositol metabolic process
L1857_33825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_33835	COG5398	heme oxygenase
L1857_33845	COG2162	N-hydroxyarylamine O-acetyltransferase activity
L1857_33855	COG2814	Major facilitator Superfamily
L1857_33875	COG2252	PERMEase
L1857_33900	COG2814	Major facilitator Superfamily
L1857_33910	COG1278	Cold shock
L1857_33920	COG0546	phosphoglycolate phosphatase activity
L1857_33930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_33935	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_33940	COG0384	phenazine biosynthesis protein PhzF
L1857_33945	COG3304	Inner membrane component domain
L1857_33965	COG2814	Major facilitator Superfamily
L1857_34000	COG1846	Transcriptional regulator
L1857_34015	COG1388	LysM domain
L1857_34065	COG2018	Roadblock/LC7 domain
L1857_34080	COG2018	Roadblock/LC7 domain
L1857_34090	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L1857_34095	COG0765	amino acid transport
L1857_34100	COG0765	amino acid transport
L1857_34120	COG1061	Type III restriction enzyme res subunit
L1857_34140	COG0693	protein deglycase activity
L1857_34150	COG1063	alcohol dehydrogenase
L1857_34155	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_34175	COG0459	protein refolding
L1857_34185	COG1278	Cold shock
L1857_34205	COG0688	phosphatidylethanolamine metabolic process
L1857_34210	COG1183	phosphatidylcholine synthase activity
L1857_34230	COG1309	transcriptional regulator
L1857_34235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1857_34265	COG0596	Alpha beta hydrolase
L1857_34275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L1857_34295	COG2022	thiamine diphosphate biosynthetic process
L1857_34305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_34305	COG2022	thiamine diphosphate biosynthetic process
L1857_34310	COG0352	thiamine-phosphate diphosphorylase activity
L1857_34315	COG3226	Transcriptional regulator
L1857_34330	COG2188	Transcriptional regulator
L1857_34335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1857_34340	COG2971	BadF BadG BcrA BcrD
L1857_34350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L1857_34365	COG3903	Transcriptional regulator
L1857_34365	COG3629	intracellular signal transduction
L1857_34370	COG5285	phytanoyl-CoA dioxygenase
L1857_34375	COG1917	Cupin 2, conserved barrel domain protein
L1857_34385	COG0456	acetyltransferase
L1857_34425	COG0346	lactoylglutathione lyase activity
L1857_34460	COG0129	dihydroxy-acid dehydratase activity
L1857_34505	COG0709	Synthesizes selenophosphate from selenide and ATP
L1857_34515	COG1832	CoA-binding protein
L1857_34520	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_34525	COG3835	regulator
L1857_34530	COG0477	Major facilitator Superfamily
L1857_34555	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_34630	COG0582	viral genome integration into host DNA
L1857_34655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L1857_34660	COG2847	Copper chaperone PCu(A)C
L1857_34665	COG1329	Transcriptional regulator
L1857_34670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L1857_34675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L1857_34680	COG0546	phosphoglycolate phosphatase activity
L1857_34685	COG0215	cysteine-tRNA ligase activity
L1857_34690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_34720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_34725	COG0698	ribose 5-phosphate isomerase
L1857_34730	COG2376	Dihydroxyacetone kinase
L1857_34735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1857_34745	COG1349	DNA-binding transcription factor activity
L1857_34750	COG2814	Major facilitator Superfamily
L1857_34755	COG1070	Carbohydrate kinase
L1857_34765	COG4399	Belongs to the UPF0754 family
L1857_34770	COG4399	Belongs to the UPF0754 family
L1857_34780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L1857_34785	COG1121	(ABC) transporter
L1857_34795	COG1609	Transcriptional regulator
L1857_34805	COG1194	a g-specific adenine glycosylase
L1857_34810	COG0667	Aldo Keto reductase
L1857_34820	COG0596	Alpha beta hydrolase
L1857_34825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1857_34835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1857_34850	COG0583	DNA-binding transcription factor activity
L1857_34875	COG0443	Heat shock 70 kDa protein
L1857_34880	COG0542	response to heat
L1857_34915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L1857_34920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L1857_34925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L1857_34950	COG0789	Transcriptional regulator
L1857_34965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1857_34975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1857_35005	COG0037	tRNA processing
L1857_35015	COG2027	D-alanyl-D-alanine carboxypeptidase
L1857_35020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L1857_35025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1857_35075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L1857_35080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L1857_35095	COG1754	DNA topoisomerase type I activity
L1857_35095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1857_35120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L1857_35125	COG1111	helicase
L1857_35125	COG1205	dead DEAH box helicase
L1857_35175	COG1472	Belongs to the glycosyl hydrolase 3 family
L1857_35180	COG3876	Protein conserved in bacteria
L1857_35185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L1857_35190	COG1737	Transcriptional regulator
L1857_35195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L1857_35205	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L1857_35215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_35240	COG0477	Major facilitator Superfamily
L1857_35250	COG4941	Belongs to the sigma-70 factor family
L1857_35270	COG3104	oligopeptide transport
L1857_35275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L1857_35285	COG2267	carboxylic ester hydrolase activity
L1857_35330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid