locus-tag	class	description
LA20533_00055	COG1970	mechanosensitive ion channel activity
LA20533_00060	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA20533_00065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LA20533_00070	COG2384	SAM-dependent methyltransferase
LA20533_00075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA20533_00080	COG0358	DNA primase activity
LA20533_00095	COG1381	Involved in DNA repair and RecF pathway recombination
LA20533_00100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LA20533_00105	COG0295	cytidine deaminase activity
LA20533_00110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LA20533_00115	COG1702	phosphate starvation-inducible protein PhoH
LA20533_00120	COG1610	YqeY-like protein
LA20533_00125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LA20533_00130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LA20533_00140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LA20533_00145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LA20533_00155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA20533_00175	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA20533_00180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA20533_00185	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA20533_00190	COG2200	EAL domain
LA20533_00195	COG1490	D-aminoacyl-tRNA deacylase activity
LA20533_00200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA20533_00210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA20533_00220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LA20533_00270	COG1063	alcohol dehydrogenase
LA20533_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LA20533_00300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LA20533_00300	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LA20533_00305	COG3764	Sortase (surface protein transpeptidase)
LA20533_00315	COG1363	Peptidase, m42
LA20533_00320	COG0484	heat shock protein binding
LA20533_00325	COG0443	Heat shock 70 kDa protein
LA20533_00330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LA20533_00335	COG1420	regulation of RNA biosynthetic process
LA20533_00340	COG0196	riboflavin kinase activity
LA20533_00350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LA20533_00355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LA20533_00355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LA20533_00365	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LA20533_00370	COG0195	Participates in both transcription termination and antitermination
LA20533_00375	COG0779	Required for maturation of 30S ribosomal subunits
LA20533_00385	COG2176	DNA-directed DNA polymerase activity
LA20533_00390	COG0442	prolyl-tRNA aminoacylation
LA20533_00395	COG0750	zinc metalloprotease
LA20533_00400	COG4589	Belongs to the CDS family
LA20533_00405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LA20533_00425	COG0366	Alpha amylase catalytic
LA20533_00440	COG0513	Belongs to the DEAD box helicase family
LA20533_00465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LA20533_00480	COG0204	Acyl-transferase
LA20533_00485	COG1132	(ABC) transporter
LA20533_00490	COG1132	(ABC) transporter
LA20533_00495	COG3763	UPF0154 protein
LA20533_00500	COG4224	UPF0291 protein
LA20533_00505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LA20533_00510	COG0783	Belongs to the Dps family
LA20533_00550	COG0295	cytidine deaminase activity
LA20533_00555	COG0335	large ribosomal subunit rRNA binding
LA20533_00565	COG2832	Protein of unknown function (DUF454)
LA20533_00570	COG0336	Belongs to the RNA methyltransferase TrmD family
LA20533_00575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LA20533_00585	COG0228	four-way junction DNA binding
LA20533_00590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA20533_00595	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LA20533_00605	COG0552	protein localization to endoplasmic reticulum
LA20533_00610	COG1196	nuclear chromosome segregation
LA20533_00615	COG0571	ribonuclease III activity
LA20533_00625	COG4608	Belongs to the ABC transporter superfamily
LA20533_00635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA20533_00640	COG0416	fatty acid biosynthetic process
LA20533_00645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA20533_00650	COG1461	Dihydroxyacetone kinase
LA20533_00655	COG1302	Protein conserved in bacteria
LA20533_00660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LA20533_00670	COG1162	GTPase activity
LA20533_00675	COG0515	serine threonine protein kinase
LA20533_00675	COG2815	serine threonine protein kinase
LA20533_00680	COG0631	protein serine/threonine phosphatase activity
LA20533_00685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA20533_00685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA20533_00690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LA20533_00695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA20533_00700	COG1758	RNA polymerase activity
LA20533_00705	COG0194	GDP metabolic process
LA20533_00725	COG0497	DNA recombination
LA20533_00730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LA20533_00740	COG1722	exodeoxyribonuclease VII activity
LA20533_00745	COG1570	exodeoxyribonuclease VII activity
LA20533_00750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LA20533_00755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA20533_00765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LA20533_00770	COG0006	proline dipeptidase activity
LA20533_00775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LA20533_00780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LA20533_00795	COG0626	cystathionine gamma-synthase activity
LA20533_00805	COG2936	dipeptidyl-peptidase activity
LA20533_00810	COG0174	glutamine synthetase
LA20533_00815	COG0789	Transcriptional regulator
LA20533_00820	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LA20533_00835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA20533_00840	COG1940	carbohydrate kinase activity
LA20533_00865	COG0768	penicillin binding
LA20533_00880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA20533_00885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA20533_00890	COG0072	phenylalanine-tRNA ligase activity
LA20533_00895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LA20533_00900	COG1733	regulation of RNA biosynthetic process
LA20533_00905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA20533_00915	COG0706	membrane insertase activity
LA20533_00920	COG2801	Transposase and inactivated derivatives
LA20533_00945	COG5002	protein histidine kinase activity
LA20533_00950	COG0745	RESPONSE REGULATOR receiver
LA20533_00955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LA20533_00970	COG2226	methyltransferase
LA20533_00975	COG0799	negative regulation of ribosome biogenesis
LA20533_00980	COG1713	HD superfamily hydrolase involved in NAD metabolism
LA20533_00985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LA20533_00995	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LA20533_01000	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LA20533_01005	COG0346	lactoylglutathione lyase activity
LA20533_01015	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA20533_01020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LA20533_01030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LA20533_01035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LA20533_01040	COG1484	DNA-dependent DNA replication
LA20533_01045	COG3611	Membrane attachment protein
LA20533_01055	COG0237	dephospho-CoA kinase activity
LA20533_01060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LA20533_01065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA20533_01065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA20533_01075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA20533_01080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA20533_01090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LA20533_01100	COG1131	(ABC) transporter
LA20533_01105	COG0537	adenosine 5'-monophosphoramidase activity
LA20533_01115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA20533_01120	COG3481	metal-dependent phosphohydrolase, HD sub domain
LA20533_01125	COG4717	serine-type aminopeptidase activity
LA20533_01130	COG0420	3'-5' exonuclease activity
LA20533_01135	COG3679	Belongs to the UPF0342 family
LA20533_01140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA20533_01145	COG0564	pseudouridine synthase activity
LA20533_01150	COG0670	Belongs to the BI1 family
LA20533_01155	COG3619	membrane
LA20533_01175	COG2252	PERMEase
LA20533_01185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LA20533_01190	COG2244	polysaccharide biosynthetic process
LA20533_01195	COG0495	leucyl-tRNA aminoacylation
LA20533_01200	COG0671	phosphoesterase, PA-phosphatase related
LA20533_01205	COG2814	Major facilitator Superfamily
LA20533_01210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LA20533_01330	COG1368	sulfuric ester hydrolase activity
LA20533_01340	COG0438	transferase activity, transferring glycosyl groups
LA20533_01345	COG0438	transferase activity, transferring glycosyl groups
LA20533_01350	COG1447	Phosphotransferase system cellobiose-specific component IIA
LA20533_01365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LA20533_01525	COG1185	polyribonucleotide nucleotidyltransferase activity
LA20533_01535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LA20533_01540	COG0586	Pfam SNARE associated Golgi protein
LA20533_01550	COG0647	UMP catabolic process
LA20533_01560	COG0737	Belongs to the 5'-nucleotidase family
LA20533_01570	COG0584	glycerophosphoryl diester phosphodiesterase
LA20533_01580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA20533_01590	COG0006	proline dipeptidase activity
LA20533_01605	COG0622	Phosphoesterase
LA20533_01610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LA20533_01615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LA20533_01625	COG3118	belongs to the thioredoxin family
LA20533_01630	COG1193	negative regulation of DNA recombination
LA20533_01645	COG3906	Belongs to the UPF0473 family
LA20533_01650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LA20533_01655	COG4472	Bacterial protein of unknown function (DUF965)
LA20533_01665	COG0513	Belongs to the DEAD box helicase family
LA20533_01670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LA20533_01675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LA20533_01680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA20533_01685	COG1862	Preprotein translocase
LA20533_01690	COG0343	queuine tRNA-ribosyltransferase activity
LA20533_01695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LA20533_01700	COG2255	four-way junction helicase activity
LA20533_01705	COG0632	four-way junction helicase activity
LA20533_01720	COG0531	amino acid
LA20533_01740	COG0488	(ABC) transporter
LA20533_01755	COG1214	PFAM Peptidase M22, glycoprotease
LA20533_01785	COG0470	DNA polymerase III
LA20533_01790	COG3870	Protein conserved in bacteria
LA20533_01815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LA20533_01825	COG0590	tRNA wobble adenosine to inosine editing
LA20533_01830	COG2813	Specifically methylates the guanine in position
LA20533_01860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LA20533_01875	COG0081	regulation of translation
LA20533_01880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LA20533_01885	COG0250	Participates in transcription elongation, termination and antitermination
LA20533_01910	COG1252	NADH dehydrogenase
LA20533_01940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA20533_01945	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LA20533_01950	COG0215	cysteine-tRNA ligase activity
LA20533_01955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA20533_01965	COG0756	dUTP diphosphatase activity
LA20533_02005	COG2963	transposase activity
LA20533_02075	COG1136	(ABC) transporter
LA20533_02090	COG0028	Belongs to the TPP enzyme family
LA20533_02100	COG1230	cation diffusion facilitator family transporter
LA20533_02135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA20533_02160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LA20533_02175	COG0425	Belongs to the sulfur carrier protein TusA family
LA20533_02175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA20533_02190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LA20533_02195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LA20533_02220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LA20533_02230	COG1193	negative regulation of DNA recombination
LA20533_02265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LA20533_02270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LA20533_02290	COG1116	anion transmembrane transporter activity
LA20533_02295	COG4120	Belongs to the binding-protein-dependent transport system permease family
LA20533_02310	COG0101	tRNA pseudouridine synthase activity
LA20533_02315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LA20533_02320	COG1122	ATPase activity
LA20533_02325	COG1122	ATPase activity
LA20533_02335	COG0202	RNA polymerase activity
LA20533_02350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LA20533_02355	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LA20533_02390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LA20533_02395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LA20533_02405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LA20533_02410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LA20533_02430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LA20533_02435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LA20533_02440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LA20533_02450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LA20533_02460	COG0088	Forms part of the polypeptide exit tunnel
LA20533_02470	COG0051	transcription antitermination factor activity, RNA binding
LA20533_02480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LA20533_02510	COG0542	response to heat
LA20533_02525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LA20533_02530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA20533_02535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LA20533_02545	COG0037	tRNA processing
LA20533_02560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LA20533_02565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA20533_02570	COG0193	aminoacyl-tRNA hydrolase activity
LA20533_02575	COG0039	L-malate dehydrogenase activity
LA20533_02595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LA20533_02610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA20533_02625	COG4608	Belongs to the ABC transporter superfamily
LA20533_02630	COG0444	Belongs to the ABC transporter superfamily
LA20533_02635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA20533_02640	COG0601	transmembrane transport
LA20533_02645	COG4166	transmembrane transport
LA20533_02650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LA20533_02655	COG0504	CTP synthase activity
LA20533_02660	COG3343	RNA polymerase activity
LA20533_02670	COG0095	Lipoate-protein ligase
LA20533_02675	COG1078	dGTPase activity
LA20533_02680	COG1970	mechanosensitive ion channel activity
LA20533_02700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LA20533_02705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LA20533_02715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LA20533_02720	COG4466	Protein conserved in bacteria
LA20533_02730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LA20533_02735	COG0084	hydrolase, TatD family'
LA20533_02740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA20533_02740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA20533_02745	COG1881	PFAM PEBP family protein
LA20533_02750	COG4989	oxidoreductase activity
LA20533_02780	COG0534	Mate efflux family protein
LA20533_02785	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LA20533_02790	COG1704	LemA family
LA20533_02795	COG1335	isochorismatase
LA20533_02800	COG2131	deaminase
LA20533_02810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA20533_02820	COG1174	glycine betaine transport
LA20533_02825	COG3973	AAA domain
LA20533_02855	COG0778	Nitroreductase
LA20533_02860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA20533_02875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LA20533_02885	COG1368	sulfuric ester hydrolase activity
LA20533_02890	COG1418	mRNA catabolic process
LA20533_02915	COG1764	response to oxidative stress
LA20533_02945	COG0463	Glycosyl transferase, family 2
LA20533_02950	COG0463	Glycosyl transferase, family 2
LA20533_02955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LA20533_02960	COG1316	TRANSCRIPTIONal
LA20533_02970	COG1114	Component of the transport system for branched-chain amino acids
LA20533_02975	COG0726	polysaccharide deacetylase
LA20533_02980	COG1122	ATPase activity
LA20533_02985	COG4120	Belongs to the binding-protein-dependent transport system permease family
LA20533_03000	COG0588	phosphoglycerate mutase activity
LA20533_03020	COG1705	Flagellar rod assembly protein muramidase FlgJ
LA20533_03020	COG1388	LysM domain
LA20533_03050	COG3158	transport of potassium into the cell
LA20533_03070	COG3590	peptidase
LA20533_03075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LA20533_03095	COG3684	Belongs to the aldolase LacD family
LA20533_03100	COG1309	transcriptional regulator
LA20533_03105	COG3559	Exporter of polyketide antibiotics
LA20533_03110	COG1131	(ABC) transporter
LA20533_03135	COG2217	Heavy metal translocating P-type atpase
LA20533_03140	COG2217	Heavy metal translocating P-type atpase
LA20533_03145	COG1914	H( )-stimulated, divalent metal cation uptake system
LA20533_03160	COG1304	FMN binding
LA20533_03165	COG1620	l-lactate permease
LA20533_03170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA20533_03180	COG0561	phosphatase activity
LA20533_03185	COG0367	asparagine synthase
LA20533_03210	COG2818	Glycosylase
LA20533_03215	COG3639	organic phosphonate transmembrane transporter activity
LA20533_03235	COG0589	response to stress
LA20533_03240	COG2365	Tyrosine phosphatase family
LA20533_03245	COG2188	Transcriptional regulator
LA20533_03250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA20533_03255	COG3715	PTS system
LA20533_03260	COG3716	PTS system mannose fructose sorbose family IID component
LA20533_03295	COG2188	Transcriptional regulator
LA20533_03330	COG0028	Belongs to the TPP enzyme family
LA20533_03345	COG0366	Alpha amylase catalytic
LA20533_03355	COG1132	(ABC) transporter
LA20533_03365	COG0656	L-ascorbic acid biosynthetic process
LA20533_03370	COG4876	unkown
LA20533_03395	COG1349	DNA-binding transcription factor activity
LA20533_03415	COG1396	sequence-specific DNA binding
LA20533_03425	COG1346	cytolysis
LA20533_03480	COG4175	Glycine betaine
LA20533_03480	COG3448	diguanylate cyclase activity
LA20533_03490	COG2910	NAD(P)H-binding
LA20533_03500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LA20533_03610	COG1136	(ABC) transporter
LA20533_03615	COG2946	Replication initiation factor
LA20533_03655	COG0328	RNA-DNA hybrid ribonuclease activity
LA20533_03675	COG0400	carboxylic ester hydrolase activity
LA20533_03680	COG0346	lactoylglutathione lyase activity
LA20533_03695	COG2738	Putative neutral zinc metallopeptidase
LA20533_03700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA20533_03720	COG0681	Belongs to the peptidase S26 family
LA20533_03725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LA20533_03730	COG0861	Integral membrane protein TerC family
LA20533_03735	COG3189	MarR family transcriptional regulator
LA20533_03740	COG2094	Belongs to the DNA glycosylase MPG family
LA20533_03750	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA20533_03755	COG0019	diaminopimelate decarboxylase activity
LA20533_03760	COG2171	N-acyltransferase activity
LA20533_03765	COG1473	amidohydrolase
LA20533_03770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA20533_03775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LA20533_03780	COG0436	Aminotransferase
LA20533_03785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA20533_03790	COG0527	aspartate kinase activity
LA20533_03800	COG0765	amino acid transport
LA20533_03805	COG1126	abc transporter atp-binding protein
LA20533_03830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LA20533_03840	COG0516	GMP reductase activity
LA20533_03850	COG2096	Adenosyltransferase
LA20533_03855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LA20533_03860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA20533_03865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LA20533_03880	COG5002	protein histidine kinase activity
LA20533_03885	COG0745	RESPONSE REGULATOR receiver
LA20533_03905	COG1442	glycosyl transferase family 8
LA20533_03910	COG1285	pathogenesis
LA20533_03915	COG2801	Transposase and inactivated derivatives
LA20533_03930	COG2261	transglycosylase associated protein
LA20533_03935	COG2261	transglycosylase associated protein
LA20533_03940	COG2261	transglycosylase associated protein
LA20533_03945	COG2261	transglycosylase associated protein
LA20533_03970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LA20533_03975	COG4974	Belongs to the 'phage' integrase family
LA20533_04045	COG2261	transglycosylase associated protein
LA20533_04055	COG1597	lipid kinase activity
LA20533_04060	COG3328	transposase activity
LA20533_04080	COG0305	Participates in initiation and elongation during chromosome replication
LA20533_04085	COG0359	binds to the 23S rRNA
LA20533_04095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LA20533_04100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LA20533_04105	COG0629	single-stranded DNA binding
LA20533_04110	COG0360	Binds together with S18 to 16S ribosomal RNA
LA20533_04115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LA20533_04120	COG0187	DNA topoisomerase II activity
LA20533_04125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LA20533_04140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LA20533_04155	COG0706	membrane insertase activity
LA20533_04160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LA20533_04175	COG1131	(ABC) transporter
LA20533_04185	COG2252	PERMEase
LA20533_04220	COG4608	Belongs to the ABC transporter superfamily
LA20533_04225	COG0444	Belongs to the ABC transporter superfamily
LA20533_04230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA20533_04235	COG0601	transmembrane transport
LA20533_04240	COG4166	transmembrane transport
LA20533_04255	COG1823	symporter activity
LA20533_04260	COG0588	phosphoglycerate mutase activity
LA20533_04265	COG0577	efflux transmembrane transporter activity
LA20533_04265	COG1136	(ABC) transporter
LA20533_04290	COG2217	Heavy metal translocating P-type atpase
LA20533_04295	COG0517	IMP dehydrogenase activity
LA20533_04305	COG0028	Belongs to the TPP enzyme family
LA20533_04335	COG1131	(ABC) transporter
LA20533_04340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LA20533_04345	COG0789	Transcriptional regulator
LA20533_04385	COG2011	ABC-type metal ion transport system permease component
LA20533_04390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA20533_04395	COG1609	Transcriptional regulator
LA20533_04405	COG0366	Alpha amylase catalytic
LA20533_04410	COG0366	Alpha amylase catalytic
LA20533_04415	COG0366	Alpha amylase catalytic
LA20533_04425	COG1175	transmembrane transport
LA20533_04430	COG3833	ABC-type maltose transport systems, permease component
LA20533_04435	COG3842	ATPase activity
LA20533_04445	COG1132	(ABC) transporter
LA20533_04450	COG1132	(ABC) transporter
LA20533_04475	COG1131	(ABC) transporter
LA20533_04505	COG2365	Tyrosine phosphatase family
LA20533_04515	COG4166	transmembrane transport
LA20533_04540	COG1028	Short-chain dehydrogenase reductase Sdr
LA20533_04575	COG3842	ATPase activity
LA20533_04610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LA20533_04625	COG3949	Membrane
LA20533_04630	COG2814	Major facilitator Superfamily
LA20533_04635	COG3548	integral membrane protein
LA20533_04645	COG0588	phosphoglycerate mutase activity
LA20533_04660	COG0167	dihydroorotate dehydrogenase activity
LA20533_04665	COG3442	glutamine amidotransferase
LA20533_04670	COG0351	phosphomethylpyrimidine kinase
LA20533_04690	COG0745	RESPONSE REGULATOR receiver
LA20533_04695	COG0704	Plays a role in the regulation of phosphate uptake
LA20533_04705	COG0573	inorganic phosphate transmembrane transporter activity
LA20533_04710	COG0581	inorganic phosphate transmembrane transporter activity
LA20533_04720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA20533_04725	COG0704	Plays a role in the regulation of phosphate uptake
LA20533_04755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LA20533_04760	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LA20533_04770	COG2188	Transcriptional regulator
LA20533_04775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LA20533_04780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LA20533_04785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LA20533_04790	COG2261	transglycosylase associated protein
LA20533_04800	COG2207	Transcriptional regulator
LA20533_04800	COG3708	Transcriptional regulator
LA20533_04810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LA20533_04815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LA20533_04820	COG0745	RESPONSE REGULATOR receiver
LA20533_04830	COG1136	(ABC) transporter
LA20533_04860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LA20533_04895	COG1285	pathogenesis
LA20533_04910	COG2084	Dehydrogenase
LA20533_04930	COG1475	DNA binding
LA20533_04935	COG1192	Involved in chromosome partitioning
LA20533_04940	COG1475	DNA binding
LA20533_04945	COG4481	Protein conserved in bacteria
LA20533_04950	COG0012	GTP binding
LA20533_04965	COG1132	(ABC) transporter
LA20533_04985	COG1686	Belongs to the peptidase S11 family
LA20533_04990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LA20533_04995	COG1794	racemase activity, acting on amino acids and derivatives
LA20533_05015	COG2814	Major facilitator Superfamily
LA20533_05020	COG0284	orotidine-5'-phosphate decarboxylase activity
LA20533_05025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LA20533_05030	COG1126	abc transporter atp-binding protein
LA20533_05035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA20533_05045	COG1105	Belongs to the carbohydrate kinase PfkB family
LA20533_05050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA20533_05050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA20533_05050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA20533_05055	COG1162	GTPase activity
LA20533_05060	COG0765	amino acid transport
LA20533_05070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA20533_05090	COG1316	TRANSCRIPTIONal
LA20533_05115	COG0488	(ABC) transporter
LA20533_05135	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LA20533_05140	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LA20533_05145	COG0813	purine-nucleoside phosphorylase activity
LA20533_05165	COG0730	response to heat
LA20533_05185	COG3715	PTS system
LA20533_05190	COG3716	PTS system mannose fructose sorbose family IID component
LA20533_05195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA20533_05210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LA20533_05215	COG4948	Mandelate Racemase Muconate Lactonizing
LA20533_05230	COG2723	6-phospho-beta-galactosidase activity
LA20533_05280	COG0583	DNA-binding transcription factor activity
LA20533_05285	COG1053	succinate dehydrogenase
LA20533_05285	COG0431	NADPH-dependent FMN reductase
LA20533_05285	COG3976	FMN-binding domain protein
LA20533_05290	COG1053	succinate dehydrogenase
LA20533_05315	COG1857	crispr-associated protein
LA20533_05330	COG1518	maintenance of DNA repeat elements
LA20533_05335	COG2176	DNA-directed DNA polymerase activity
LA20533_05340	COG0500	methyltransferase
LA20533_05380	COG0574	Belongs to the PEP-utilizing enzyme family
LA20533_05380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA20533_05390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LA20533_05400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA20533_05405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA20533_05410	COG1780	Probably involved in ribonucleotide reductase function
LA20533_05415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA20533_05440	COG1126	abc transporter atp-binding protein
LA20533_05445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA20533_05450	COG0765	amino acid transport
LA20533_05455	COG0765	amino acid transport
LA20533_05460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA20533_05470	COG1136	(ABC) transporter
LA20533_05485	COG3973	AAA domain
LA20533_05490	COG1053	succinate dehydrogenase
LA20533_05490	COG0431	NADPH-dependent FMN reductase
LA20533_05490	COG3976	FMN-binding domain protein
LA20533_05515	COG0519	Catalyzes the synthesis of GMP from XMP
LA20533_05520	COG0582	viral genome integration into host DNA
LA20533_05555	COG3328	transposase activity
LA20533_05575	COG0791	NLP P60 protein
LA20533_05575	COG0741	lytic transglycosylase activity
LA20533_05625	COG2946	Replication initiation factor
LA20533_05630	COG1674	ftsk spoiiie
LA20533_05675	COG1674	ftsk spoiiie
LA20533_05735	COG0488	(ABC) transporter
LA20533_05745	COG4221	oxidoreductase activity
LA20533_05750	COG0789	Transcriptional regulator
LA20533_05760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LA20533_05765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LA20533_05795	COG1070	Carbohydrate kinase
LA20533_05800	COG5549	protein import
LA20533_05800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA20533_05810	COG1428	Deoxynucleoside kinase
LA20533_05820	COG0346	lactoylglutathione lyase activity
LA20533_05825	COG3022	response to hydroperoxide
LA20533_05850	COG2502	aspartate--ammonia ligase
LA20533_05855	COG0686	Belongs to the AlaDH PNT family
LA20533_05885	COG1902	pentaerythritol trinitrate reductase activity
LA20533_05890	COG1012	belongs to the aldehyde dehydrogenase family
LA20533_05905	COG0546	phosphoglycolate phosphatase activity
LA20533_05920	COG1131	(ABC) transporter
LA20533_05925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LA20533_05950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA20533_05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA20533_05960	COG0765	amino acid transport
LA20533_05965	COG1126	abc transporter atp-binding protein
LA20533_05970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LA20533_05990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LA20533_06035	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LA20533_06040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA20533_06050	COG3104	oligopeptide transport
LA20533_06070	COG2188	Transcriptional regulator
LA20533_06080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LA20533_06085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LA20533_06115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LA20533_06130	COG3091	SprT-like family
LA20533_06155	COG1278	Cold shock
LA20533_06160	COG1705	Flagellar rod assembly protein muramidase FlgJ
LA20533_06160	COG1388	LysM domain
LA20533_06165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LA20533_06170	COG2233	PERMEase
LA20533_06180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LA20533_06185	COG4851	CamS sex pheromone cAM373 precursor
LA20533_06195	COG0154	amidase activity
LA20533_06200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LA20533_06205	COG1597	lipid kinase activity
LA20533_06210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA20533_06220	COG0582	viral genome integration into host DNA
LA20533_06225	COG3759	membrane
LA20533_06265	COG1253	flavin adenine dinucleotide binding
LA20533_06275	COG0531	amino acid
LA20533_06285	COG0673	inositol 2-dehydrogenase activity
LA20533_06295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LA20533_06305	COG2309	aminopeptidase activity
LA20533_06310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LA20533_06315	COG2246	polysaccharide biosynthetic process
LA20533_06325	COG0716	FMN binding
LA20533_06330	COG0024	Methionine aminopeptidase
LA20533_06340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA20533_06350	COG0183	Belongs to the thiolase family
LA20533_06360	COG3425	synthase
LA20533_06365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA20533_06375	COG3557	Belongs to the UPF0374 family
LA20533_06410	COG1253	flavin adenine dinucleotide binding
LA20533_06415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LA20533_06425	COG0542	response to heat
LA20533_06455	COG0642	Histidine kinase
LA20533_06460	COG0745	RESPONSE REGULATOR receiver
LA20533_06465	COG1136	(ABC) transporter
LA20533_06470	COG0577	efflux transmembrane transporter activity
LA20533_06475	COG1234	tRNA 3'-trailer cleavage
LA20533_06480	COG1393	Belongs to the ArsC family
LA20533_06505	COG2357	RelA SpoT domain protein
LA20533_06515	COG0564	pseudouridine synthase activity
LA20533_06520	COG2239	Acts as a magnesium transporter
LA20533_06525	COG3142	Participates in the control of copper homeostasis
LA20533_06535	COG2706	6-phosphogluconolactonase activity
LA20533_06540	COG3731	PTS system glucitol sorbitol-specific IIA component
LA20533_06545	COG0628	permease
LA20533_06560	COG1674	ftsk spoiiie
LA20533_06570	COG0612	Peptidase, M16
LA20533_06575	COG0300	oxidoreductase activity
LA20533_06580	COG1426	Protein conserved in bacteria
LA20533_06585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LA20533_06590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LA20533_06595	COG1418	mRNA catabolic process
LA20533_06600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA20533_06605	COG1739	Uncharacterized protein family UPF0029
LA20533_06610	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LA20533_06625	COG0653	protein targeting
LA20533_06630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LA20533_06635	COG2884	Cell division ATP-binding protein ftsE
LA20533_06640	COG2177	Part of the ABC transporter FtsEX involved in
LA20533_06650	COG0573	inorganic phosphate transmembrane transporter activity
LA20533_06655	COG0581	inorganic phosphate transmembrane transporter activity
LA20533_06660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA20533_06665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA20533_06670	COG0704	Plays a role in the regulation of phosphate uptake
LA20533_06675	COG1983	PspC domain protein
LA20533_06690	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LA20533_06695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LA20533_06700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LA20533_06705	COG0492	ferredoxin-NADP+ reductase activity
LA20533_06710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA20533_06715	COG0556	nucleotide-excision repair
LA20533_06720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LA20533_06745	COG1846	Transcriptional regulator
LA20533_06760	COG4619	ABC transporter
LA20533_06765	COG0390	transport system, permease component
LA20533_06785	COG2390	Transcriptional regulator
LA20533_06795	COG0126	phosphoglycerate kinase activity
LA20533_06815	COG1647	Serine aminopeptidase, S33
LA20533_06820	COG0557	exoribonuclease II activity
LA20533_06850	COG0583	DNA-binding transcription factor activity
LA20533_06865	COG0561	phosphatase activity
LA20533_06870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LA20533_06875	COG0280	phosphate acetyltransferase
LA20533_06880	COG0802	atpase or kinase
LA20533_06885	COG2176	DNA-directed DNA polymerase activity
LA20533_06890	COG0708	Exodeoxyribonuclease III
LA20533_06895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LA20533_06910	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA20533_06915	COG1177	transmembrane transport
LA20533_06945	COG4708	membrane
LA20533_06950	COG0561	phosphatase activity
LA20533_06970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA20533_07005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LA20533_07010	COG1131	(ABC) transporter
LA20533_07035	COG1598	PFAM Uncharacterised protein family UPF0150
LA20533_07040	COG4975	Glucose uptake
LA20533_07045	COG1482	cell wall glycoprotein biosynthetic process
LA20533_07050	COG0745	RESPONSE REGULATOR receiver
LA20533_07055	COG3850	Histidine kinase
LA20533_07055	COG5002	protein histidine kinase activity
LA20533_07060	COG1368	sulfuric ester hydrolase activity
LA20533_07085	COG1316	TRANSCRIPTIONal
LA20533_07095	COG0489	protein tyrosine kinase activity
LA20533_07100	COG4464	protein tyrosine phosphatase activity
LA20533_07105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA20533_07120	COG3475	LICD family
LA20533_07155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LA20533_07165	COG1088	dTDP-glucose 4,6-dehydratase activity
LA20533_07170	COG1091	dTDP-4-dehydrorhamnose reductase activity
LA20533_07200	COG3715	PTS system
LA20533_07205	COG3716	PTS system mannose fructose sorbose family IID component
LA20533_07215	COG0166	Belongs to the GPI family
LA20533_07240	COG0306	phosphate transporter
LA20533_07245	COG1392	Phosphate transport regulator
LA20533_07265	COG1309	transcriptional regulator
LA20533_07280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA20533_07285	COG1435	thymidine kinase activity
LA20533_07295	COG2890	protein-(glutamine-N5) methyltransferase activity
LA20533_07300	COG0009	L-threonylcarbamoyladenylate synthase
LA20533_07305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LA20533_07315	COG0356	it plays a direct role in the translocation of protons across the membrane
LA20533_07320	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LA20533_07325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LA20533_07330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LA20533_07340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LA20533_07345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LA20533_07360	COG1077	Cell shape determining protein MreB Mrl
LA20533_07370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LA20533_07380	COG0772	Belongs to the SEDS family
LA20533_07385	COG0509	glycine decarboxylation via glycine cleavage system
LA20533_07405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA20533_07420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LA20533_07425	COG1104	cysteine desulfurase activity
LA20533_07430	COG0301	tRNA thio-modification
LA20533_07435	COG0525	valine-tRNA ligase activity
LA20533_07445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA20533_07450	COG2003	Belongs to the UPF0758 family
LA20533_07455	COG1077	Cell shape determining protein MreB Mrl
LA20533_07460	COG1792	Involved in formation and maintenance of cell shape
LA20533_07490	COG0275	rRNA processing
LA20533_07500	COG0768	penicillin binding
LA20533_07505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA20533_07510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LA20533_07520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LA20533_07530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LA20533_07535	COG1799	cell septum assembly
LA20533_07550	COG3599	regulation of cell shape
LA20533_07555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LA20533_07560	COG1278	Cold shock
LA20533_07565	COG0494	nUDIX hydrolase
LA20533_07580	COG1104	cysteine desulfurase activity
LA20533_07590	COG0482	sulfurtransferase activity
LA20533_07610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LA20533_07615	COG1597	lipid kinase activity
LA20533_07620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LA20533_07625	COG5503	Protein of unknown function (DUF1447)
LA20533_07630	COG0242	peptide deformylase activity
LA20533_07655	COG0483	inositol monophosphate 1-phosphatase activity
LA20533_07660	COG1217	gtp-binding protein TYPA
LA20533_07665	COG0772	Belongs to the SEDS family
LA20533_07675	COG0742	ribosomal rna small subunit methyltransferase
LA20533_07685	COG3480	Lon protease (S16) C-terminal proteolytic domain
LA20533_07690	COG1596	polysaccharide export
LA20533_07690	COG1555	photosystem II stabilization
LA20533_07695	COG0658	competence protein
LA20533_07695	COG2333	competence protein COMEC
LA20533_07700	COG1466	dna polymerase III delta subunit
LA20533_07705	COG0268	Binds directly to 16S ribosomal RNA
LA20533_07710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LA20533_07740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LA20533_07745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LA20533_07750	COG0018	arginyl-trna synthetase
LA20533_07755	COG0765	amino acid transport
LA20533_07760	COG1126	abc transporter atp-binding protein
LA20533_07765	COG0322	excinuclease ABC activity
LA20533_07775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LA20533_07775	COG2755	lipolytic protein G-D-S-L family
LA20533_07780	COG1234	tRNA 3'-trailer cleavage
LA20533_07785	COG0300	oxidoreductase activity
LA20533_07795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LA20533_07800	COG0737	Belongs to the 5'-nucleotidase family
LA20533_07810	COG0587	DNA-directed DNA polymerase activity
LA20533_07825	COG2996	Protein conserved in bacteria
LA20533_07850	COG1187	pseudouridine synthase activity
LA20533_07855	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LA20533_07865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LA20533_07870	COG0539	negative regulation of cytoplasmic translation
LA20533_07875	COG1160	GTP binding
LA20533_07895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LA20533_07910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LA20533_07920	COG1272	protein, Hemolysin III
LA20533_07925	COG1307	EDD domain protein, DegV family
LA20533_07930	COG4479	Belongs to the UPF0346 family
LA20533_07935	COG3409	Peptidoglycan-binding domain 1 protein
LA20533_07935	COG0793	Belongs to the peptidase S41A family
LA20533_07940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LA20533_07945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LA20533_07950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LA20533_07955	COG0758	DNA mediated transformation
LA20533_07960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA20533_07990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LA20533_07995	COG0187	DNA topoisomerase II activity
LA20533_08000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LA20533_08005	COG0583	DNA-binding transcription factor activity
LA20533_08010	COG1227	inorganic diphosphatase activity
LA20533_08015	COG1307	EDD domain protein, DegV family
LA20533_08025	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LA20533_08030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LA20533_08035	COG0505	Belongs to the CarA family
LA20533_08045	COG0564	pseudouridine synthase activity
LA20533_08070	COG1307	EDD domain protein, DegV family
LA20533_08075	COG0095	Lipoate-protein ligase
LA20533_08085	COG1546	Belongs to the CinA family
LA20533_08085	COG1058	Belongs to the CinA family
LA20533_08100	COG0116	Belongs to the methyltransferase superfamily
LA20533_08110	COG3599	regulation of cell shape
LA20533_08115	COG4474	Belongs to the UPF0398 family
LA20533_08120	COG3331	DNA recombination
LA20533_08125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA20533_08130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA20533_08140	COG0017	Asparaginyl-tRNA synthetase
LA20533_08150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA20533_08150	COG1199	ATP-dependent helicase activity
LA20533_08155	COG1074	ATP-dependent DNA helicase activity
LA20533_08160	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LA20533_08180	COG1304	FMN binding
LA20533_08185	COG1132	(ABC) transporter
LA20533_08230	COG1942	4-Oxalocrotonate Tautomerase
LA20533_08235	COG1970	mechanosensitive ion channel activity
LA20533_08240	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA20533_08245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LA20533_08250	COG2384	SAM-dependent methyltransferase
LA20533_08255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA20533_08260	COG0358	DNA primase activity
LA20533_08275	COG1381	Involved in DNA repair and RecF pathway recombination
LA20533_08280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LA20533_08285	COG0295	cytidine deaminase activity
LA20533_08290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LA20533_08295	COG1702	phosphate starvation-inducible protein PhoH
LA20533_08300	COG1610	YqeY-like protein
LA20533_08305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LA20533_08310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LA20533_08325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA20533_08345	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA20533_08350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA20533_08355	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA20533_08360	COG2200	EAL domain
LA20533_08365	COG1490	D-aminoacyl-tRNA deacylase activity
LA20533_08380	COG1385	rRNA (uridine-N3-)-methyltransferase activity