locus-tag	class	description
Anacy_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Anacy_0002	COG2076	Multidrug Resistance protein
Anacy_0004	COG0723	plastoquinol--plastocyanin reductase activity
Anacy_0011	COG1216	Glycosyl transferase, family 2
Anacy_0011	COG0463	Glycosyl transferase, family 2
Anacy_0012	COG1131	(ABC) transporter
Anacy_0014	COG0003	Pfam Anion-transporting ATPase
Anacy_0015	COG4251	negative regulation of phosphorylation
Anacy_0015	COG2203	Gaf domain
Anacy_0015	COG3706	GGDEF domain
Anacy_0015	COG5001	Diguanylate cyclase
Anacy_0016	COG0592	DNA-directed DNA polymerase activity
Anacy_0017	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Anacy_0018	COG2211	Major facilitator Superfamily
Anacy_0020	COG0708	Exodeoxyribonuclease III
Anacy_0022	COG3118	belongs to the thioredoxin family
Anacy_0024	COG2264	protein methyltransferase activity
Anacy_0025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Anacy_0029	COG1850	ribulose-bisphosphate carboxylase activity
Anacy_0031	COG4451	ribulose bisphosphate carboxylase, small
Anacy_0042	COG1121	(ABC) transporter
Anacy_0043	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Anacy_0046	COG0659	secondary active sulfate transmembrane transporter activity
Anacy_0048	COG1271	oxidase subunit
Anacy_0049	COG1294	oxidase, subunit
Anacy_0064	COG4208	sulfate ABC transporter
Anacy_0065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Anacy_0066	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Anacy_0067	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Anacy_0068	COG0784	Response regulator, receiver
Anacy_0069	COG0121	glutamine amidotransferase
Anacy_0078	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Anacy_0094	COG0629	single-stranded DNA binding
Anacy_0095	COG2084	Dehydrogenase
Anacy_0098	COG1301	dicarboxylic acid transport
Anacy_0099	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Anacy_0100	COG0589	response to stress
Anacy_0100	COG0475	glutathione-regulated potassium exporter activity
Anacy_0102	COG0456	acetyltransferase
Anacy_0104	COG4771	TonB-dependent receptor
Anacy_0106	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Anacy_0114	COG2217	Heavy metal translocating P-type atpase
Anacy_0119	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Anacy_0120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Anacy_0121	COG0189	ligase activity
Anacy_0122	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Anacy_0132	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anacy_0139	COG0006	proline dipeptidase activity
Anacy_0140	COG0384	phenazine biosynthesis protein PhzF
Anacy_0145	COG0612	Peptidase, M16
Anacy_0146	COG0612	Peptidase, M16
Anacy_0159	COG3000	fatty acid hydroxylase
Anacy_0159	COG0300	oxidoreductase activity
Anacy_0162	COG2066	Belongs to the glutaminase family
Anacy_0163	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Anacy_0165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Anacy_0168	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anacy_0181	COG0784	Response regulator, receiver
Anacy_0181	COG2205	protein histidine kinase activity
Anacy_0184	COG0800	Aldolase
Anacy_0187	COG5002	protein histidine kinase activity
Anacy_0187	COG2205	protein histidine kinase activity
Anacy_0187	COG0784	Response regulator, receiver
Anacy_0210	COG0443	Heat shock 70 kDa protein
Anacy_0211	COG4294	response to UV
Anacy_0214	COG1045	serine acetyltransferase
Anacy_0218	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Anacy_0219	COG5554	nitrogen fixation
Anacy_0224	COG3118	belongs to the thioredoxin family
Anacy_0229	COG3546	catalase activity
Anacy_0230	COG2261	transglycosylase associated protein
Anacy_0231	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Anacy_0232	COG5398	heme oxygenase
Anacy_0233	COG2202	Pas domain
Anacy_0233	COG2205	protein histidine kinase activity
Anacy_0237	COG1716	ATPase activity
Anacy_0237	COG5001	Diguanylate cyclase
Anacy_0238	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Anacy_0240	COG0497	DNA recombination
Anacy_0243	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Anacy_0248	COG3311	Transcriptional regulator
Anacy_0249	COG1569	PIN domain
Anacy_0250	COG1063	alcohol dehydrogenase
Anacy_0251	COG0306	phosphate transporter
Anacy_0252	COG0697	spore germination
Anacy_0255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Anacy_0256	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Anacy_0257	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Anacy_0258	COG0745	RESPONSE REGULATOR receiver
Anacy_0259	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Anacy_0260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Anacy_0261	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Anacy_0262	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Anacy_0266	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Anacy_0270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Anacy_0271	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Anacy_0272	COG0511	ligase activity, forming carbon-carbon bonds
Anacy_0275	COG2988	succinylglutamate desuccinylase activity
Anacy_0278	COG0438	transferase activity, transferring glycosyl groups
Anacy_0281	COG1132	(ABC) transporter
Anacy_0284	COG0489	protein tyrosine kinase activity
Anacy_0285	COG0438	transferase activity, transferring glycosyl groups
Anacy_0289	COG1216	Glycosyl transferase, family 2
Anacy_0292	COG1216	Glycosyl transferase, family 2
Anacy_0294	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Anacy_0295	COG0579	oxidoreductase
Anacy_0296	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Anacy_0299	COG4245	von Willebrand factor, type A
Anacy_0300	COG0784	Response regulator, receiver
Anacy_0301	COG3842	ATPase activity
Anacy_0302	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Anacy_0304	COG5635	Nacht domain
Anacy_0304	COG2319	Wd-40 repeat
Anacy_0308	COG2226	methyltransferase
Anacy_0311	COG0438	transferase activity, transferring glycosyl groups
Anacy_0315	COG0438	transferase activity, transferring glycosyl groups
Anacy_0316	COG0438	transferase activity, transferring glycosyl groups
Anacy_0318	COG1160	GTP binding
Anacy_0320	COG1487	ribonuclease activity
Anacy_0322	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Anacy_0327	COG0745	RESPONSE REGULATOR receiver
Anacy_0330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Anacy_0333	COG0133	tryptophan synthase activity
Anacy_0339	COG0701	Predicted permease
Anacy_0348	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_0349	COG0072	phenylalanine-tRNA ligase activity
Anacy_0349	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Anacy_0350	COG0110	maltose O-acetyltransferase activity
Anacy_0352	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Anacy_0355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Anacy_0356	COG0745	RESPONSE REGULATOR receiver
Anacy_0359	COG3536	Protein conserved in bacteria
Anacy_0363	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Anacy_0367	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Anacy_0369	COG0483	inositol monophosphate 1-phosphatase activity
Anacy_0370	COG0484	heat shock protein binding
Anacy_0371	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Anacy_0372	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_0377	COG1672	PFAM Archaeal ATPase
Anacy_0377	COG2319	Wd-40 repeat
Anacy_0379	COG1595	DNA-templated transcription, initiation
Anacy_0383	COG1672	PFAM Archaeal ATPase
Anacy_0383	COG2319	Wd-40 repeat
Anacy_0386	COG1505	serine-type exopeptidase activity
Anacy_0391	COG0784	Response regulator, receiver
Anacy_0393	COG0037	tRNA processing
Anacy_0396	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Anacy_0400	COG0439	Biotin carboxylase
Anacy_0403	COG0515	serine threonine protein kinase
Anacy_0406	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Anacy_0409	COG0492	ferredoxin-NADP+ reductase activity
Anacy_0412	COG0233	cytoplasmic translational termination
Anacy_0414	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Anacy_0421	COG0170	dolichyl monophosphate biosynthetic process
Anacy_0423	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Anacy_0424	COG3937	granule-associated protein
Anacy_0425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Anacy_0426	COG0631	protein serine/threonine phosphatase activity
Anacy_0430	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Anacy_0431	COG2205	protein histidine kinase activity
Anacy_0432	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Anacy_0434	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Anacy_0435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Anacy_0436	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Anacy_0437	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anacy_0438	COG0456	acetyltransferase
Anacy_0446	COG2010	Cytochrome c
Anacy_0450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anacy_0462	COG0556	nucleotide-excision repair
Anacy_0465	COG0390	transport system, permease component
Anacy_0479	COG0583	DNA-binding transcription factor activity
Anacy_0482	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Anacy_0482	COG4451	ribulose bisphosphate carboxylase, small
Anacy_0483	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Anacy_0484	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Anacy_0485	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Anacy_0486	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Anacy_0487	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_0492	COG2274	protein secretion by the type I secretion system
Anacy_0501	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Anacy_0507	COG2062	phosphohistidine phosphatase, SixA
Anacy_0508	COG0372	Belongs to the citrate synthase family
Anacy_0509	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Anacy_0511	COG0839	Belongs to the complex I subunit 6 family
Anacy_0512	COG0713	ATP synthesis coupled electron transport
Anacy_0516	COG5002	protein histidine kinase activity
Anacy_0517	COG0745	RESPONSE REGULATOR receiver
Anacy_0518	COG2226	methyltransferase
Anacy_0520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Anacy_0523	COG2255	four-way junction helicase activity
Anacy_0526	COG1819	glycosyl
Anacy_0534	COG0525	valine-tRNA ligase activity
Anacy_0537	COG0113	porphobilinogen synthase activity
Anacy_0542	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Anacy_0546	COG0438	transferase activity, transferring glycosyl groups
Anacy_0549	COG2890	protein-(glutamine-N5) methyltransferase activity
Anacy_0553	COG0454	-acetyltransferase
Anacy_0556	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Anacy_0561	COG2052	Domain of unknown function (DUF370)
Anacy_0566	COG0142	geranyltranstransferase activity
Anacy_0568	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Anacy_0571	COG0475	glutathione-regulated potassium exporter activity
Anacy_0573	COG0629	single-stranded DNA binding
Anacy_0574	COG1077	Cell shape determining protein MreB Mrl
Anacy_0577	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Anacy_0577	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Anacy_0583	COG1487	ribonuclease activity
Anacy_0585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Anacy_0587	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Anacy_0592	COG4249	Peptidase C14 caspase catalytic subunit p20
Anacy_0592	COG2319	Wd-40 repeat
Anacy_0596	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Anacy_0598	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Anacy_0604	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Anacy_0605	COG1690	Belongs to the RtcB family
Anacy_0606	COG0697	spore germination
Anacy_0607	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Anacy_0609	COG2082	Precorrin-8x methylmutase
Anacy_0617	COG0745	RESPONSE REGULATOR receiver
Anacy_0618	COG1366	Belongs to the anti-sigma-factor antagonist family
Anacy_0620	COG0783	Belongs to the Dps family
Anacy_0622	COG2385	sporulation resulting in formation of a cellular spore
Anacy_0623	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Anacy_0625	COG0024	Methionine aminopeptidase
Anacy_0638	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Anacy_0638	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Anacy_0639	COG1982	Orn Lys Arg decarboxylase major
Anacy_0642	COG2205	protein histidine kinase activity
Anacy_0643	COG0745	RESPONSE REGULATOR receiver
Anacy_0657	COG0514	ATP-dependent DNA helicase (RecQ)
Anacy_0660	COG1022	Amp-dependent synthetase and ligase
Anacy_0663	COG0508	dehydrogenase complex catalyzes the overall conversion of
Anacy_0667	COG2166	iron-sulfur cluster assembly
Anacy_0674	COG3609	addiction module antidote protein, CC2985 family
Anacy_0682	COG1429	ligase activity, forming nitrogen-metal bonds
Anacy_0691	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Anacy_0692	COG4106	trans-aconitate 2-methyltransferase activity
Anacy_0693	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Anacy_0699	COG1247	-acetyltransferase
Anacy_0701	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Anacy_0702	COG1741	Belongs to the pirin family
Anacy_0706	COG0793	Belongs to the peptidase S41A family
Anacy_0713	COG0826	peptidase U32
Anacy_0717	COG1834	amidinotransferase
Anacy_0741	COG5002	protein histidine kinase activity
Anacy_0741	COG0784	Response regulator, receiver
Anacy_0741	COG2198	Histidine kinase
Anacy_0755	COG0693	protein deglycase activity
Anacy_0759	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Anacy_0760	COG0830	nickel cation binding
Anacy_0761	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Anacy_0764	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Anacy_0766	COG3258	Cytochrome c
Anacy_0772	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Anacy_0773	COG0509	glycine decarboxylation via glycine cleavage system
Anacy_0783	COG4232	protein-disulfide reductase activity
Anacy_0784	COG0697	spore germination
Anacy_0787	COG0659	secondary active sulfate transmembrane transporter activity
Anacy_0789	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Anacy_0789	COG0674	pyruvate-flavodoxin oxidoreductase activity
Anacy_0789	COG1013	pyruvate-flavodoxin oxidoreductase activity
Anacy_0789	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Anacy_0799	COG0023	Translation Initiation Factor
Anacy_0802	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Anacy_0809	COG0784	Response regulator, receiver
Anacy_0809	COG2205	protein histidine kinase activity
Anacy_0809	COG5002	protein histidine kinase activity
Anacy_0811	COG0571	ribonuclease III activity
Anacy_0817	COG0598	Magnesium transport protein CorA
Anacy_0818	COG0681	Belongs to the peptidase S26 family
Anacy_0819	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Anacy_0820	COG0802	atpase or kinase
Anacy_0821	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Anacy_0822	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Anacy_0826	COG0045	succinate-CoA ligase (ADP-forming) activity
Anacy_0831	COG4636	protein conserved in cyanobacteria
Anacy_0839	COG2197	response regulator
Anacy_0843	COG3265	gluconokinase activity
Anacy_0849	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Anacy_0850	COG0406	alpha-ribazole phosphatase activity
Anacy_0851	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Anacy_0853	COG1073	alpha beta
Anacy_0856	COG1215	transferase activity, transferring glycosyl groups
Anacy_0857	COG1215	transferase activity, transferring glycosyl groups
Anacy_0869	COG0463	Glycosyl transferase, family 2
Anacy_0871	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Anacy_0872	COG0552	protein localization to endoplasmic reticulum
Anacy_0873	COG2208	phosphoserine phosphatase activity
Anacy_0882	COG2363	Small membrane protein
Anacy_0887	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Anacy_0889	COG0772	Belongs to the SEDS family
Anacy_0892	COG0649	NAD binding
Anacy_0898	COG0275	rRNA processing
Anacy_0901	COG4172	Belongs to the ABC transporter superfamily
Anacy_0912	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Anacy_0913	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anacy_0914	COG1937	Protein conserved in bacteria
Anacy_0915	COG0596	Alpha beta hydrolase
Anacy_0917	COG0702	epimerase
Anacy_0924	COG0514	ATP-dependent DNA helicase (RecQ)
Anacy_0936	COG0850	regulation of cytokinetic process
Anacy_0937	COG2894	cell division
Anacy_0938	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Anacy_0943	COG0667	Aldo Keto reductase
Anacy_0949	COG0270	DNA (cytosine-5-)-methyltransferase activity
Anacy_0951	COG1160	GTP binding
Anacy_0956	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Anacy_0961	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Anacy_0973	COG1122	ATPase activity
Anacy_0974	COG0357	Ribosomal RNA small subunit methyltransferase G
Anacy_0983	COG0538	isocitrate dehydrogenase activity
Anacy_0984	COG0515	serine threonine protein kinase
Anacy_0985	COG5002	protein histidine kinase activity
Anacy_0985	COG0784	Response regulator, receiver
Anacy_0989	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Anacy_0991	COG0697	spore germination
Anacy_0992	COG1943	Transposase
Anacy_0993	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Anacy_1002	COG0805	protein transport
Anacy_1003	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Anacy_1004	COG1420	regulation of RNA biosynthetic process
Anacy_1008	COG1045	serine acetyltransferase
Anacy_1023	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Anacy_1024	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Anacy_1025	COG3409	Peptidoglycan-binding domain 1 protein
Anacy_1025	COG3429	Glucose-6-phosphate dehydrogenase subunit
Anacy_1026	COG1797	cobyrinic acid a,c-diamide synthase activity
Anacy_1039	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
Anacy_1040	COG0716	FMN binding
Anacy_1047	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Anacy_1050	COG0440	acetolactate synthase activity
Anacy_1053	COG0784	Response regulator, receiver
Anacy_1055	COG0840	transmembrane signaling receptor activity
Anacy_1055	COG2203	Gaf domain
Anacy_1056	COG0643	Histidine kinase
Anacy_1056	COG2198	Histidine kinase
Anacy_1061	COG3959	Transketolase, thiamine diphosphate binding domain
Anacy_1065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Anacy_1066	COG1695	Transcriptional regulator
Anacy_1067	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
Anacy_1068	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
Anacy_1074	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Anacy_1086	COG0745	RESPONSE REGULATOR receiver
Anacy_1087	COG0642	Histidine kinase
Anacy_1090	COG0723	plastoquinol--plastocyanin reductase activity
Anacy_1103	COG2133	pyrroloquinoline quinone binding
Anacy_1105	COG4191	Histidine kinase
Anacy_1108	COG1940	carbohydrate kinase activity
Anacy_1111	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Anacy_1116	COG5002	protein histidine kinase activity
Anacy_1117	COG0151	Belongs to the GarS family
Anacy_1118	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anacy_1124	COG2205	protein histidine kinase activity
Anacy_1124	COG0784	Response regulator, receiver
Anacy_1125	COG0415	Belongs to the DNA photolyase family
Anacy_1126	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Anacy_1129	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Anacy_1130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Anacy_1131	COG2161	toxin-antitoxin pair type II binding
Anacy_1133	COG0590	tRNA wobble adenosine to inosine editing
Anacy_1136	COG4948	Mandelate Racemase Muconate Lactonizing
Anacy_1149	COG1024	Enoyl-CoA hydratase
Anacy_1150	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_1152	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Anacy_1152	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Anacy_1153	COG2197	response regulator
Anacy_1154	COG2815	serine threonine protein kinase
Anacy_1154	COG0515	serine threonine protein kinase
Anacy_1176	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anacy_1177	COG3012	SEC-C Motif Domain Protein
Anacy_1178	COG2361	Protein of unknown function DUF86
Anacy_1194	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Anacy_1200	COG2255	four-way junction helicase activity
Anacy_1207	COG4644	lycopene metabolic process
Anacy_1211	COG1205	dead DEAH box helicase
Anacy_1211	COG1111	helicase
Anacy_1218	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Anacy_1234	COG1487	ribonuclease activity
Anacy_1235	COG4974	Belongs to the 'phage' integrase family
Anacy_1240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anacy_1241	COG1959	2 iron, 2 sulfur cluster binding
Anacy_1242	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Anacy_1246	COG0730	response to heat
Anacy_1247	COG0671	phosphoesterase, PA-phosphatase related
Anacy_1251	COG0730	response to heat
Anacy_1257	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Anacy_1258	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_1261	COG0667	Aldo Keto reductase
Anacy_1262	COG3659	wide pore channel activity
Anacy_1266	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_1267	COG2175	clavaminate synthase activity
Anacy_1268	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Anacy_1269	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_1270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Anacy_1271	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Anacy_1272	COG0431	NADPH-dependent FMN reductase
Anacy_1275	COG3852	Histidine kinase
Anacy_1276	COG1285	pathogenesis
Anacy_1277	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Anacy_1279	COG4221	oxidoreductase activity
Anacy_1283	COG3903	Transcriptional regulator
Anacy_1283	COG2319	Wd-40 repeat
Anacy_1288	COG3240	lipase activity
Anacy_1293	COG0577	efflux transmembrane transporter activity
Anacy_1293	COG1136	(ABC) transporter
Anacy_1298	COG2091	lysine biosynthetic process via aminoadipic acid
Anacy_1305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anacy_1306	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Anacy_1312	COG0625	glutathione transferase activity
Anacy_1326	COG0667	Aldo Keto reductase
Anacy_1327	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_1328	COG1132	(ABC) transporter
Anacy_1353	COG0673	inositol 2-dehydrogenase activity
Anacy_1360	COG2304	oxidoreductase activity
Anacy_1363	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anacy_1366	COG1902	pentaerythritol trinitrate reductase activity
Anacy_1370	COG0180	Tryptophanyl-tRNA synthetase
Anacy_1371	COG1032	radical SAM domain protein
Anacy_1375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_1379	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Anacy_1387	COG0582	viral genome integration into host DNA
Anacy_1407	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Anacy_1408	COG0640	Transcriptional regulator
Anacy_1409	COG1121	(ABC) transporter
Anacy_1410	COG0803	Belongs to the bacterial solute-binding protein 9 family
Anacy_1411	COG3659	wide pore channel activity
Anacy_1413	COG3437	response regulator, receiver
Anacy_1413	COG4999	Histidine kinase
Anacy_1413	COG3850	Histidine kinase
Anacy_1413	COG2205	protein histidine kinase activity
Anacy_1414	COG0456	acetyltransferase
Anacy_1417	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Anacy_1418	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Anacy_1419	COG0022	dehydrogenase e1 component
Anacy_1419	COG0508	dehydrogenase complex catalyzes the overall conversion of
Anacy_1427	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Anacy_1433	COG1187	pseudouridine synthase activity
Anacy_1435	COG0515	serine threonine protein kinase
Anacy_1435	COG3266	domain, Protein
Anacy_1440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Anacy_1443	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Anacy_1447	COG0673	inositol 2-dehydrogenase activity
Anacy_1450	COG4968	Prepilin-type N-terminal cleavage methylation domain
Anacy_1451	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Anacy_1452	COG0492	ferredoxin-NADP+ reductase activity
Anacy_1453	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Anacy_1455	COG1940	carbohydrate kinase activity
Anacy_1457	COG0504	CTP synthase activity
Anacy_1458	COG0860	N-Acetylmuramoyl-L-alanine amidase
Anacy_1458	COG4991	sh3 domain protein
Anacy_1458	COG3103	Sh3 type 3 domain protein
Anacy_1459	COG0860	N-Acetylmuramoyl-L-alanine amidase
Anacy_1459	COG4991	sh3 domain protein
Anacy_1459	COG3103	Sh3 type 3 domain protein
Anacy_1463	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Anacy_1466	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Anacy_1467	COG3977	Valine--pyruvate aminotransferase
Anacy_1468	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Anacy_1471	COG0412	Dienelactone hydrolase
Anacy_1473	COG0837	glucose binding
Anacy_1478	COG0157	Belongs to the NadC ModD family
Anacy_1489	COG0243	molybdopterin cofactor binding
Anacy_1490	COG2223	nitrite transmembrane transporter activity
Anacy_1492	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_1499	COG0583	DNA-binding transcription factor activity
Anacy_1500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Anacy_1504	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Anacy_1505	COG1518	maintenance of DNA repeat elements
Anacy_1512	COG4804	nuclease activity
Anacy_1513	COG2442	InterPro IPR007367
Anacy_1518	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Anacy_1519	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Anacy_1521	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Anacy_1525	COG1027	Aspartate ammonia-lyase
Anacy_1526	COG0750	zinc metalloprotease
Anacy_1528	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Anacy_1529	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Anacy_1531	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Anacy_1534	COG0242	peptide deformylase activity
Anacy_1538	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Anacy_1538	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Anacy_1541	COG0793	Belongs to the peptidase S41A family
Anacy_1544	COG2501	S4 domain
Anacy_1545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Anacy_1549	COG1842	Phage shock protein A
Anacy_1550	COG1842	Phage shock protein A
Anacy_1551	COG3118	belongs to the thioredoxin family
Anacy_1552	COG0436	Aminotransferase
Anacy_1557	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Anacy_1561	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Anacy_1568	COG2208	phosphoserine phosphatase activity
Anacy_1568	COG2770	Histidine kinase
Anacy_1569	COG1366	Belongs to the anti-sigma-factor antagonist family
Anacy_1570	COG0515	serine threonine protein kinase
Anacy_1573	COG0628	permease
Anacy_1576	COG0523	cobalamin synthesis protein
Anacy_1577	COG1785	Belongs to the alkaline phosphatase family
Anacy_1579	COG0521	Mo-molybdopterin cofactor biosynthetic process
Anacy_1581	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anacy_1582	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Anacy_1586	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Anacy_1590	COG0395	ABC-type sugar transport system, permease component
Anacy_1591	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Anacy_1596	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Anacy_1603	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Anacy_1604	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anacy_1605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Anacy_1608	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anacy_1611	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Anacy_1614	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Anacy_1619	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_1619	COG0515	serine threonine protein kinase
Anacy_1620	COG5002	protein histidine kinase activity
Anacy_1620	COG0784	Response regulator, receiver
Anacy_1630	COG0745	RESPONSE REGULATOR receiver
Anacy_1631	COG5002	protein histidine kinase activity
Anacy_1632	COG0704	Plays a role in the regulation of phosphate uptake
Anacy_1633	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anacy_1635	COG3659	wide pore channel activity
Anacy_1636	COG3659	wide pore channel activity
Anacy_1649	COG3852	Histidine kinase
Anacy_1651	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Anacy_1651	COG0426	domain, Protein
Anacy_1652	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Anacy_1652	COG0426	domain, Protein
Anacy_1657	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Anacy_1659	COG0745	RESPONSE REGULATOR receiver
Anacy_1661	COG5002	protein histidine kinase activity
Anacy_1662	COG5002	protein histidine kinase activity
Anacy_1664	COG0628	permease
Anacy_1666	COG1316	TRANSCRIPTIONal
Anacy_1670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Anacy_1672	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Anacy_1672	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Anacy_1676	COG0393	Putative heavy-metal-binding
Anacy_1680	COG0719	Fe-S assembly protein
Anacy_1681	COG0396	ATPase activity
Anacy_1682	COG0719	Fe-S assembly protein
Anacy_1683	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Anacy_1685	COG0523	cobalamin synthesis protein
Anacy_1689	COG2124	cytochrome p450
Anacy_1695	COG2124	cytochrome p450
Anacy_1696	COG0297	glycogen (starch) synthase activity
Anacy_1709	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Anacy_1710	COG4221	oxidoreductase activity
Anacy_1718	COG1619	proteins homologs of microcin C7 resistance protein MccF
Anacy_1733	COG0237	dephospho-CoA kinase activity
Anacy_1733	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Anacy_1738	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Anacy_1740	COG0356	it plays a direct role in the translocation of protons across the membrane
Anacy_1744	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Anacy_1745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Anacy_1746	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Anacy_1754	COG0431	NADPH-dependent FMN reductase
Anacy_1755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anacy_1759	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_1760	COG5001	Diguanylate cyclase
Anacy_1760	COG2203	Gaf domain
Anacy_1760	COG3706	GGDEF domain
Anacy_1760	COG4251	negative regulation of phosphorylation
Anacy_1762	COG0582	viral genome integration into host DNA
Anacy_1764	COG2442	InterPro IPR007367
Anacy_1775	COG4680	protein conserved in bacteria
Anacy_1777	COG2337	Toxic component of a toxin-antitoxin (TA) module
Anacy_1801	COG0298	carbon dioxide binding
Anacy_1802	COG0409	Hydrogenase expression formation protein
Anacy_1805	COG0375	protein maturation
Anacy_1806	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Anacy_1808	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Anacy_1810	COG0284	orotidine-5'-phosphate decarboxylase activity
Anacy_1810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Anacy_1812	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Anacy_1812	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Anacy_1813	COG1196	nuclear chromosome segregation
Anacy_1813	COG0741	lytic transglycosylase activity
Anacy_1813	COG0739	heme binding
Anacy_1819	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Anacy_1820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Anacy_1834	COG3237	CsbD-like
Anacy_1837	COG0762	integral membrane protein
Anacy_1839	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Anacy_1846	COG1131	(ABC) transporter
Anacy_1850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Anacy_1851	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Anacy_1860	COG0395	ABC-type sugar transport system, permease component
Anacy_1862	COG2010	Cytochrome c
Anacy_1863	COG3794	PFAM blue (type 1) copper domain protein
Anacy_1864	COG2010	Cytochrome c
Anacy_1868	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Anacy_1869	COG2202	Pas domain
Anacy_1869	COG2205	protein histidine kinase activity
Anacy_1872	COG0784	Response regulator, receiver
Anacy_1873	COG3437	response regulator, receiver
Anacy_1873	COG2205	protein histidine kinase activity
Anacy_1873	COG3850	Histidine kinase
Anacy_1873	COG4999	Histidine kinase
Anacy_1875	COG2197	response regulator
Anacy_1886	COG0438	transferase activity, transferring glycosyl groups
Anacy_1888	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_1888	COG0515	serine threonine protein kinase
Anacy_1893	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Anacy_1894	COG0784	Response regulator, receiver
Anacy_1895	COG0564	pseudouridine synthase activity
Anacy_1898	COG0237	dephospho-CoA kinase activity
Anacy_1899	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Anacy_1900	COG1413	lyase activity
Anacy_1901	COG1413	lyase activity
Anacy_1902	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Anacy_1903	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Anacy_1904	COG0237	dephospho-CoA kinase activity
Anacy_1907	COG0019	diaminopimelate decarboxylase activity
Anacy_1910	COG0367	asparagine synthase
Anacy_1919	COG0572	uridine kinase
Anacy_1920	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Anacy_1921	COG2203	Gaf domain
Anacy_1921	COG3706	GGDEF domain
Anacy_1921	COG4251	negative regulation of phosphorylation
Anacy_1921	COG5001	Diguanylate cyclase
Anacy_1921	COG2203	Gaf domain
Anacy_1921	COG3706	GGDEF domain
Anacy_1921	COG4251	negative regulation of phosphorylation
Anacy_1921	COG5001	Diguanylate cyclase
Anacy_1924	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Anacy_1926	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Anacy_1929	COG1085	galactose-1-phosphate uridylyltransferase
Anacy_1932	COG3507	Belongs to the glycosyl hydrolase 43 family
Anacy_1933	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Anacy_1934	COG1091	dTDP-4-dehydrorhamnose reductase activity
Anacy_1936	COG0562	UDP-galactopyranose mutase
Anacy_1944	COG1012	belongs to the aldehyde dehydrogenase family
Anacy_1953	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Anacy_1958	COG0123	including yeast histone deacetylase and acetoin utilization protein
Anacy_1965	COG2274	protein secretion by the type I secretion system
Anacy_1966	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Anacy_1967	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Anacy_1972	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_1973	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_1975	COG0515	serine threonine protein kinase
Anacy_1976	COG0515	serine threonine protein kinase
Anacy_1993	COG1979	alcohol dehydrogenase
Anacy_2003	COG0739	heme binding
Anacy_2005	COG5001	Diguanylate cyclase
Anacy_2005	COG2203	Gaf domain
Anacy_2005	COG4251	negative regulation of phosphorylation
Anacy_2005	COG3706	GGDEF domain
Anacy_2006	COG4221	oxidoreductase activity
Anacy_2007	COG1309	transcriptional regulator
Anacy_2011	COG1252	NADH dehydrogenase
Anacy_2013	COG1733	regulation of RNA biosynthetic process
Anacy_2014	COG0702	epimerase
Anacy_2017	COG1104	cysteine desulfurase activity
Anacy_2024	COG0793	Belongs to the peptidase S41A family
Anacy_2025	COG4251	negative regulation of phosphorylation
Anacy_2025	COG3706	GGDEF domain
Anacy_2025	COG5001	Diguanylate cyclase
Anacy_2025	COG2203	Gaf domain
Anacy_2035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Anacy_2041	COG0739	heme binding
Anacy_2041	COG0741	lytic transglycosylase activity
Anacy_2041	COG1196	nuclear chromosome segregation
Anacy_2042	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anacy_2045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Anacy_2049	COG2197	response regulator
Anacy_2052	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Anacy_2054	COG0776	regulation of translation
Anacy_2063	COG0285	dihydrofolate synthase activity
Anacy_2065	COG0110	maltose O-acetyltransferase activity
Anacy_2068	COG0612	Peptidase, M16
Anacy_2070	COG0024	Methionine aminopeptidase
Anacy_2071	COG0154	amidase activity
Anacy_2075	COG4106	trans-aconitate 2-methyltransferase activity
Anacy_2082	COG1252	NADH dehydrogenase
Anacy_2086	COG0277	FAD linked oxidase domain protein
Anacy_2087	COG0247	lactate metabolic process
Anacy_2088	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Anacy_2091	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anacy_2105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Anacy_2107	COG0822	iron-sulfur transferase activity
Anacy_2107	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Anacy_2107	COG2906	2 iron, 2 sulfur cluster binding
Anacy_2116	COG0582	viral genome integration into host DNA
Anacy_2118	COG0582	viral genome integration into host DNA
Anacy_2122	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_2132	COG0582	viral genome integration into host DNA
Anacy_2142	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_2145	COG4974	Belongs to the 'phage' integrase family
Anacy_2158	COG1192	Involved in chromosome partitioning
Anacy_2214	COG0582	viral genome integration into host DNA
Anacy_2216	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anacy_2218	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anacy_2219	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anacy_2222	COG5420	small protein containing a coiled-coil domain
Anacy_2226	COG0633	Ferredoxin
Anacy_2232	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Anacy_2232	COG2755	lipolytic protein G-D-S-L family
Anacy_2242	COG1252	NADH dehydrogenase
Anacy_2247	COG1295	ribonuclease BN
Anacy_2253	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Anacy_2258	COG1902	pentaerythritol trinitrate reductase activity
Anacy_2260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Anacy_2262	COG0004	ammonium transporteR
Anacy_2263	COG0515	serine threonine protein kinase
Anacy_2263	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_2269	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Anacy_2270	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Anacy_2274	COG0751	glycine-tRNA ligase activity
Anacy_2275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Anacy_2278	COG2234	aminopeptidase activity
Anacy_2281	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Anacy_2283	COG1132	(ABC) transporter
Anacy_2284	COG0741	lytic transglycosylase activity
Anacy_2287	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Anacy_2290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Anacy_2291	COG0228	four-way junction DNA binding
Anacy_2293	COG1702	phosphate starvation-inducible protein PhoH
Anacy_2297	COG1132	(ABC) transporter
Anacy_2299	COG0563	adenylate kinase activity
Anacy_2300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Anacy_2301	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Anacy_2302	COG0363	glucosamine-6-phosphate deaminase activity
Anacy_2303	COG1716	ATPase activity
Anacy_2307	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Anacy_2308	COG2208	phosphoserine phosphatase activity
Anacy_2308	COG2770	Histidine kinase
Anacy_2312	COG1366	Belongs to the anti-sigma-factor antagonist family
Anacy_2319	COG3659	wide pore channel activity
Anacy_2322	COG1234	tRNA 3'-trailer cleavage
Anacy_2328	COG2373	Large extracellular alpha-helical protein
Anacy_2329	COG4953	penicillin-binding protein 1C
Anacy_2331	COG1090	epimerase
Anacy_2334	COG0316	Belongs to the HesB IscA family
Anacy_2337	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Anacy_2339	COG0753	catalase activity
Anacy_2341	COG1492	cobalamin metabolic process
Anacy_2343	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Anacy_2350	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Anacy_2352	COG0457	Tetratricopeptide repeat
Anacy_2352	COG0463	Glycosyl transferase, family 2
Anacy_2354	COG0436	Aminotransferase
Anacy_2356	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Anacy_2363	COG0596	Alpha beta hydrolase
Anacy_2365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Anacy_2366	COG0572	uridine kinase
Anacy_2368	COG0460	homoserine dehydrogenase
Anacy_2369	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Anacy_2370	COG0784	Response regulator, receiver
Anacy_2370	COG2205	protein histidine kinase activity
Anacy_2376	COG2815	serine threonine protein kinase
Anacy_2376	COG0515	serine threonine protein kinase
Anacy_2380	COG1131	(ABC) transporter
Anacy_2381	COG4251	negative regulation of phosphorylation
Anacy_2381	COG2203	Gaf domain
Anacy_2381	COG3706	GGDEF domain
Anacy_2381	COG5001	Diguanylate cyclase
Anacy_2382	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Anacy_2384	COG1316	TRANSCRIPTIONal
Anacy_2387	COG0728	peptidoglycan biosynthetic process
Anacy_2391	COG4636	protein conserved in cyanobacteria
Anacy_2395	COG1950	PFAM Membrane protein of
Anacy_2397	COG2183	response to ionizing radiation
Anacy_2403	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anacy_2403	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
Anacy_2403	COG3321	synthase
Anacy_2403	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Anacy_2405	COG4932	domain protein
Anacy_2405	COG3266	domain, Protein
Anacy_2405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Anacy_2405	COG4932	domain protein
Anacy_2405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Anacy_2405	COG3266	domain, Protein
Anacy_2408	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Anacy_2415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Anacy_2416	COG0193	aminoacyl-tRNA hydrolase activity
Anacy_2418	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Anacy_2421	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Anacy_2423	COG1218	3'(2'),5'-bisphosphate nucleotidase
Anacy_2440	COG0166	Belongs to the GPI family
Anacy_2441	COG3852	Histidine kinase
Anacy_2447	COG1598	PFAM Uncharacterised protein family UPF0150
Anacy_2448	COG0730	response to heat
Anacy_2449	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Anacy_2453	COG1494	fructose-1,6-bisphosphatase
Anacy_2454	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Anacy_2455	COG0590	tRNA wobble adenosine to inosine editing
Anacy_2457	COG4249	Peptidase C14 caspase catalytic subunit p20
Anacy_2457	COG2319	Wd-40 repeat
Anacy_2460	COG1404	Belongs to the peptidase S8 family
Anacy_2460	COG4935	Belongs to the peptidase S8 family
Anacy_2462	COG0271	Belongs to the BolA IbaG family
Anacy_2463	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Anacy_2465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Anacy_2467	COG0745	RESPONSE REGULATOR receiver
Anacy_2468	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Anacy_2477	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Anacy_2481	COG1530	ribonuclease E activity
Anacy_2482	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Anacy_2484	COG0077	Prephenate dehydratase
Anacy_2484	COG1605	Chorismate mutase
Anacy_2485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Anacy_2486	COG0051	transcription antitermination factor activity, RNA binding
Anacy_2487	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Anacy_2488	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Anacy_2489	COG0049	tRNA binding
Anacy_2491	COG0316	Belongs to the HesB IscA family
Anacy_2492	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Anacy_2492	COG0662	Cupin 2, conserved barrel domain protein
Anacy_2495	COG0069	glutamate synthase activity
Anacy_2495	COG0067	glutamate synthase
Anacy_2495	COG0070	glutamate synthase
Anacy_2496	COG0726	polysaccharide deacetylase
Anacy_2498	COG0463	Glycosyl transferase, family 2
Anacy_2502	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Anacy_2506	COG0824	Thioesterase
Anacy_2510	COG0501	Belongs to the peptidase M48B family
Anacy_2527	COG5002	protein histidine kinase activity
Anacy_2528	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Anacy_2529	COG2201	protein-glutamate methylesterase activity
Anacy_2533	COG2205	protein histidine kinase activity
Anacy_2536	COG3240	lipase activity
Anacy_2546	COG0668	transmembrane transport
Anacy_2549	COG1160	GTP binding
Anacy_2550	COG1716	ATPase activity
Anacy_2550	COG5001	Diguanylate cyclase
Anacy_2551	COG2203	Gaf domain
Anacy_2551	COG3706	GGDEF domain
Anacy_2551	COG5001	Diguanylate cyclase
Anacy_2551	COG4251	negative regulation of phosphorylation
Anacy_2554	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Anacy_2555	COG0330	HflC and HflK could
Anacy_2556	COG4279	zinc finger
Anacy_2558	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anacy_2558	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anacy_2571	COG4372	Transposase
Anacy_2573	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Anacy_2574	COG0131	Imidazoleglycerol-phosphate dehydratase
Anacy_2575	COG1131	(ABC) transporter
Anacy_2576	COG1596	polysaccharide export
Anacy_2580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Anacy_2581	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Anacy_2584	COG1063	alcohol dehydrogenase
Anacy_2588	COG3266	domain, Protein
Anacy_2588	COG0515	serine threonine protein kinase
Anacy_2592	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Anacy_2593	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Anacy_2595	COG0084	hydrolase, TatD family'
Anacy_2596	COG0268	Binds directly to 16S ribosomal RNA
Anacy_2598	COG0589	response to stress
Anacy_2600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Anacy_2610	COG0612	Peptidase, M16
Anacy_2613	COG0515	serine threonine protein kinase
Anacy_2613	COG3266	domain, Protein
Anacy_2614	COG0222	ribosome binding
Anacy_2615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Anacy_2618	COG0250	Participates in transcription elongation, termination and antitermination
Anacy_2619	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Anacy_2621	COG0463	Glycosyl transferase, family 2
Anacy_2623	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Anacy_2626	COG0724	RNA recognition motif
Anacy_2629	COG3654	unkown
Anacy_2632	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Anacy_2632	COG0426	domain, Protein
Anacy_2633	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Anacy_2633	COG0426	domain, Protein
Anacy_2634	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Anacy_2642	COG1691	(AIR) carboxylase
Anacy_2643	COG0747	negative chemotaxis
Anacy_2646	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Anacy_2648	COG4242	Belongs to the peptidase S51 family
Anacy_2650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Anacy_2651	COG0515	serine threonine protein kinase
Anacy_2651	COG3266	domain, Protein
Anacy_2652	COG0515	serine threonine protein kinase
Anacy_2654	COG0575	Belongs to the CDS family
Anacy_2656	COG1187	pseudouridine synthase activity
Anacy_2658	COG1640	4-alpha-glucanotransferase
Anacy_2661	COG0251	oxidation-reduction process
Anacy_2662	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Anacy_2665	COG1053	succinate dehydrogenase
Anacy_2669	COG0277	FAD linked oxidase domain protein
Anacy_2672	COG2203	Gaf domain
Anacy_2672	COG5001	Diguanylate cyclase
Anacy_2672	COG4251	negative regulation of phosphorylation
Anacy_2672	COG3706	GGDEF domain
Anacy_2676	COG0148	phosphopyruvate hydratase activity
Anacy_2677	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Anacy_2678	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Anacy_2678	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Anacy_2683	COG1410	methionine synthase
Anacy_2683	COG0646	methionine synthase
Anacy_2685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Anacy_2689	COG0783	Belongs to the Dps family
Anacy_2690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Anacy_2691	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anacy_2695	COG0516	GMP reductase activity
Anacy_2695	COG0517	IMP dehydrogenase activity
Anacy_2699	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Anacy_2707	COG0482	sulfurtransferase activity
Anacy_2709	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Anacy_2709	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Anacy_2713	COG2119	membrane
Anacy_2714	COG4680	protein conserved in bacteria
Anacy_2716	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Anacy_2717	COG0187	DNA topoisomerase II activity
Anacy_2717	COG1372	Participates in initiation and elongation during chromosome replication
Anacy_2718	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anacy_2720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Anacy_2724	COG1136	(ABC) transporter
Anacy_2724	COG0577	efflux transmembrane transporter activity
Anacy_2725	COG1136	(ABC) transporter
Anacy_2727	COG1309	transcriptional regulator
Anacy_2729	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Anacy_2730	COG0577	efflux transmembrane transporter activity
Anacy_2730	COG1136	(ABC) transporter
Anacy_2731	COG1136	(ABC) transporter
Anacy_2732	COG2205	protein histidine kinase activity
Anacy_2732	COG0784	Response regulator, receiver
Anacy_2733	COG2197	response regulator
Anacy_2737	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Anacy_2738	COG0546	phosphoglycolate phosphatase activity
Anacy_2744	COG2884	Cell division ATP-binding protein ftsE
Anacy_2746	COG3344	reverse transcriptase
Anacy_2752	COG4783	chaperone-mediated protein folding
Anacy_2760	COG4636	protein conserved in cyanobacteria
Anacy_2761	COG0542	response to heat
Anacy_2762	COG0346	lactoylglutathione lyase activity
Anacy_2767	COG0577	efflux transmembrane transporter activity
Anacy_2767	COG1136	(ABC) transporter
Anacy_2768	COG0628	permease
Anacy_2772	COG3706	GGDEF domain
Anacy_2772	COG2203	Gaf domain
Anacy_2772	COG5001	Diguanylate cyclase
Anacy_2772	COG4251	negative regulation of phosphorylation
Anacy_2775	COG2176	DNA-directed DNA polymerase activity
Anacy_2776	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Anacy_2776	COG1215	transferase activity, transferring glycosyl groups
Anacy_2778	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Anacy_2779	COG3118	belongs to the thioredoxin family
Anacy_2781	COG0583	DNA-binding transcription factor activity
Anacy_2782	COG0515	serine threonine protein kinase
Anacy_2783	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Anacy_2785	COG0778	Nitroreductase
Anacy_2786	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Anacy_2787	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anacy_2788	COG0018	arginyl-trna synthetase
Anacy_2789	COG0561	phosphatase activity
Anacy_2790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Anacy_2790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Anacy_2791	COG2203	Gaf domain
Anacy_2791	COG2199	diguanylate cyclase activity
Anacy_2794	COG0464	growth
Anacy_2798	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Anacy_2801	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_2812	COG1487	ribonuclease activity
Anacy_2817	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Anacy_2818	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Anacy_2819	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Anacy_2821	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Anacy_2824	COG0706	membrane insertase activity
Anacy_2835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anacy_2837	COG5001	Diguanylate cyclase
Anacy_2837	COG1716	ATPase activity
Anacy_2838	COG0419	ATPase involved in DNA repair
Anacy_2842	COG0745	RESPONSE REGULATOR receiver
Anacy_2843	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Anacy_2848	COG0779	Required for maturation of 30S ribosomal subunits
Anacy_2849	COG0195	Participates in both transcription termination and antitermination
Anacy_2862	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Anacy_2878	COG1032	radical SAM domain protein
Anacy_2887	COG5002	protein histidine kinase activity
Anacy_2889	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Anacy_2890	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Anacy_2891	COG2202	Pas domain
Anacy_2891	COG2205	protein histidine kinase activity
Anacy_2894	COG0735	belongs to the Fur family
Anacy_2895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anacy_2896	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Anacy_2897	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Anacy_2898	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Anacy_2898	COG2205	protein histidine kinase activity
Anacy_2901	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Anacy_2902	COG0436	Aminotransferase
Anacy_2904	COG1285	pathogenesis
Anacy_2906	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Anacy_2907	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Anacy_2909	COG1672	PFAM Archaeal ATPase
Anacy_2911	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Anacy_2917	COG4680	protein conserved in bacteria
Anacy_2924	COG1122	ATPase activity
Anacy_2926	COG0310	cobalt ion transport
Anacy_2932	COG2132	Multicopper oxidase
Anacy_2937	COG0672	)-iron permease
Anacy_2938	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Anacy_2939	COG0746	molybdenum cofactor guanylyltransferase activity
Anacy_2941	COG1331	Highly conserved protein containing a thioredoxin domain
Anacy_2943	COG0740	serine-type endopeptidase activity
Anacy_2945	COG0557	exoribonuclease II activity
Anacy_2946	COG0163	prenyltransferase activity
Anacy_2949	COG3903	Transcriptional regulator
Anacy_2949	COG2319	Wd-40 repeat
Anacy_2950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Anacy_2955	COG0259	pyridoxamine-phosphate oxidase activity
Anacy_2956	COG0628	permease
Anacy_2958	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Anacy_2959	COG1166	arginine decarboxylase activity
Anacy_2960	COG0105	UTP biosynthetic process
Anacy_2961	COG0861	Integral membrane protein TerC family
Anacy_2969	COG1943	Transposase
Anacy_2971	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Anacy_2980	COG2010	Cytochrome c
Anacy_2984	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Anacy_2996	COG0651	ATP synthesis coupled electron transport
Anacy_2999	COG0765	amino acid transport
Anacy_3007	COG0625	glutathione transferase activity
Anacy_3018	COG0215	cysteine-tRNA ligase activity
Anacy_3029	COG0284	orotidine-5'-phosphate decarboxylase activity
Anacy_3036	COG1573	uracil-dna glycosylase
Anacy_3039	COG0154	amidase activity
Anacy_3040	COG1733	regulation of RNA biosynthetic process
Anacy_3043	COG0587	DNA-directed DNA polymerase activity
Anacy_3045	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Anacy_3047	COG0363	glucosamine-6-phosphate deaminase activity
Anacy_3049	COG1136	(ABC) transporter
Anacy_3051	COG1566	PFAM secretion protein HlyD family protein
Anacy_3053	COG3321	synthase
Anacy_3053	COG0604	alcohol dehydrogenase
Anacy_3055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Anacy_3055	COG2070	2-Nitropropane dioxygenase
Anacy_3059	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anacy_3059	COG3320	Male sterility
Anacy_3068	COG2226	methyltransferase
Anacy_3075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Anacy_3076	COG1799	cell septum assembly
Anacy_3077	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Anacy_3085	COG4581	dead DEAH box helicase
Anacy_3091	COG2217	Heavy metal translocating P-type atpase
Anacy_3098	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Anacy_3101	COG1662	PFAM IS1 transposase
Anacy_3102	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_3104	COG3852	Histidine kinase
Anacy_3105	COG0625	glutathione transferase activity
Anacy_3106	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Anacy_3107	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Anacy_3111	COG0731	radical SAM domain protein
Anacy_3113	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Anacy_3114	COG0588	phosphoglycerate mutase activity
Anacy_3127	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Anacy_3130	COG3266	domain, Protein
Anacy_3130	COG0515	serine threonine protein kinase
Anacy_3131	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Anacy_3132	COG4221	oxidoreductase activity
Anacy_3134	COG0598	Magnesium transport protein CorA
Anacy_3137	COG1950	PFAM Membrane protein of
Anacy_3141	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_3142	COG0581	inorganic phosphate transmembrane transporter activity
Anacy_3143	COG0573	inorganic phosphate transmembrane transporter activity
Anacy_3144	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Anacy_3147	COG0300	oxidoreductase activity
Anacy_3148	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anacy_3148	COG3320	Male sterility
Anacy_3149	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Anacy_3149	COG2070	2-Nitropropane dioxygenase
Anacy_3152	COG3321	synthase
Anacy_3152	COG4221	oxidoreductase activity
Anacy_3152	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Anacy_3152	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_3153	COG0604	alcohol dehydrogenase
Anacy_3153	COG3321	synthase
Anacy_3160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Anacy_3161	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Anacy_3162	COG3639	organic phosphonate transmembrane transporter activity
Anacy_3163	COG3624	Phosphonate C-P lyase system protein PhnG
Anacy_3166	COG3626	phosphonate metabolism
Anacy_3167	COG3454	Phosphonate metabolism
Anacy_3168	COG3627	carbon phosphorus lyase activity
Anacy_3169	COG4107	phosphonate C-P lyase system protein PhnK
Anacy_3170	COG4778	phosphonate C-P lyase system protein PhnL
Anacy_3171	COG2201	protein-glutamate methylesterase activity
Anacy_3174	COG0840	transmembrane signaling receptor activity
Anacy_3174	COG2203	Gaf domain
Anacy_3175	COG0643	Histidine kinase
Anacy_3175	COG2198	Histidine kinase
Anacy_3177	COG1176	ABC-type spermidine putrescine transport system, permease component I
Anacy_3179	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Anacy_3180	COG3842	ATPase activity
Anacy_3181	COG0768	penicillin binding
Anacy_3184	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Anacy_3185	COG2211	Major facilitator Superfamily
Anacy_3191	COG0584	glycerophosphoryl diester phosphodiesterase
Anacy_3196	COG0438	transferase activity, transferring glycosyl groups
Anacy_3197	COG0463	Glycosyl transferase, family 2
Anacy_3197	COG1216	Glycosyl transferase, family 2
Anacy_3200	COG1215	transferase activity, transferring glycosyl groups
Anacy_3202	COG1215	transferase activity, transferring glycosyl groups
Anacy_3205	COG0457	Tetratricopeptide repeat
Anacy_3206	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Anacy_3207	COG0739	heme binding
Anacy_3208	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Anacy_3209	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Anacy_3210	COG0542	response to heat
Anacy_3216	COG2081	HI0933 family
Anacy_3219	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Anacy_3220	COG2831	hemolysin activation secretion protein
Anacy_3222	COG0312	modulator of DNA gyrase
Anacy_3223	COG0312	modulator of DNA gyrase
Anacy_3227	COG4191	Histidine kinase
Anacy_3230	COG2244	polysaccharide biosynthetic process
Anacy_3231	COG1215	transferase activity, transferring glycosyl groups
Anacy_3237	COG1366	Belongs to the anti-sigma-factor antagonist family
Anacy_3238	COG0745	RESPONSE REGULATOR receiver
Anacy_3239	COG5002	protein histidine kinase activity
Anacy_3239	COG0784	Response regulator, receiver
Anacy_3239	COG2205	protein histidine kinase activity
Anacy_3242	COG0628	permease
Anacy_3243	COG0494	nUDIX hydrolase
Anacy_3245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Anacy_3247	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Anacy_3251	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Anacy_3257	COG1132	(ABC) transporter
Anacy_3259	COG0745	RESPONSE REGULATOR receiver
Anacy_3259	COG3706	GGDEF domain
Anacy_3261	COG3118	belongs to the thioredoxin family
Anacy_3266	COG1733	regulation of RNA biosynthetic process
Anacy_3269	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Anacy_3273	COG0443	Heat shock 70 kDa protein
Anacy_3284	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Anacy_3285	COG0484	heat shock protein binding
Anacy_3287	COG2205	protein histidine kinase activity
Anacy_3287	COG4999	Histidine kinase
Anacy_3287	COG3437	response regulator, receiver
Anacy_3287	COG3850	Histidine kinase
Anacy_3289	COG0481	GTPase activity
Anacy_3293	COG0827	DNA restriction-modification system
Anacy_3295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Anacy_3296	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anacy_3298	COG0848	biopolymer transport protein
Anacy_3301	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Anacy_3303	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Anacy_3304	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Anacy_3305	COG5002	protein histidine kinase activity
Anacy_3308	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Anacy_3310	COG3878	Protein conserved in bacteria
Anacy_3312	COG0450	alkyl hydroperoxide reductase
Anacy_3315	COG0484	heat shock protein binding
Anacy_3321	COG4636	protein conserved in cyanobacteria
Anacy_3327	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Anacy_3334	COG0300	oxidoreductase activity
Anacy_3335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Anacy_3339	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Anacy_3342	COG2205	protein histidine kinase activity
Anacy_3343	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Anacy_3346	COG0572	uridine kinase
Anacy_3347	COG4251	negative regulation of phosphorylation
Anacy_3348	COG2203	Gaf domain
Anacy_3348	COG3706	GGDEF domain
Anacy_3348	COG4251	negative regulation of phosphorylation
Anacy_3348	COG5001	Diguanylate cyclase
Anacy_3350	COG2203	Gaf domain
Anacy_3350	COG3706	GGDEF domain
Anacy_3350	COG4251	negative regulation of phosphorylation
Anacy_3350	COG5001	Diguanylate cyclase
Anacy_3351	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Anacy_3352	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Anacy_3353	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Anacy_3355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Anacy_3356	COG2124	cytochrome p450
Anacy_3362	COG0012	GTP binding
Anacy_3363	COG0515	serine threonine protein kinase
Anacy_3363	COG2815	serine threonine protein kinase
Anacy_3365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Anacy_3369	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Anacy_3371	COG0432	Pfam Uncharacterised protein family UPF0047
Anacy_3373	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Anacy_3376	COG0515	serine threonine protein kinase
Anacy_3377	COG0515	serine threonine protein kinase
Anacy_3382	COG1846	Transcriptional regulator
Anacy_3383	COG1649	PFAM Uncharacterised BCR, COG1649
Anacy_3384	COG0402	S-adenosylhomocysteine deaminase activity
Anacy_3388	COG0395	ABC-type sugar transport system, permease component
Anacy_3389	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Anacy_3390	COG5322	oxidoreductase activity
Anacy_3391	COG0825	malonyl-CoA metabolic process
Anacy_3392	COG0300	oxidoreductase activity
Anacy_3393	COG0302	gtp cyclohydrolase
Anacy_3398	COG0135	phosphoribosylanthranilate isomerase activity
Anacy_3400	COG1994	Peptidase M50
Anacy_3400	COG0517	IMP dehydrogenase activity
Anacy_3403	COG0739	heme binding
Anacy_3405	COG1388	LysM domain
Anacy_3405	COG1376	ErfK ybiS ycfS ynhG family protein
Anacy_3406	COG1595	DNA-templated transcription, initiation
Anacy_3408	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Anacy_3410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Anacy_3411	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Anacy_3411	COG0515	serine threonine protein kinase
Anacy_3413	COG0495	leucyl-tRNA aminoacylation
Anacy_3422	COG1372	Participates in initiation and elongation during chromosome replication
Anacy_3422	COG0305	Participates in initiation and elongation during chromosome replication
Anacy_3423	COG0359	binds to the 23S rRNA
Anacy_3428	COG1132	(ABC) transporter
Anacy_3429	COG0438	transferase activity, transferring glycosyl groups
Anacy_3434	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Anacy_3435	COG0308	aminopeptidase N
Anacy_3446	COG0408	coproporphyrinogen oxidase activity
Anacy_3447	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Anacy_3454	COG3688	RNA-binding protein containing a PIN domain
Anacy_3455	COG1122	ATPase activity
Anacy_3458	COG3659	wide pore channel activity
Anacy_3459	COG1959	2 iron, 2 sulfur cluster binding
Anacy_3460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Anacy_3461	COG0484	heat shock protein binding
Anacy_3468	COG2226	methyltransferase
Anacy_3469	COG2045	Belongs to the ComB family
Anacy_3471	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anacy_3473	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Anacy_3474	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Anacy_3477	COG1192	Involved in chromosome partitioning
Anacy_3484	COG0488	(ABC) transporter
Anacy_3488	COG0725	ABC transporter, periplasmic molybdate-binding protein
Anacy_3491	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Anacy_3498	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_3498	COG0515	serine threonine protein kinase
Anacy_3500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Anacy_3501	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Anacy_3501	COG0140	phosphoribosyl-ATP diphosphatase activity
Anacy_3504	COG2154	pterin-4-alpha-carbinolamine dehydratase
Anacy_3511	COG1487	ribonuclease activity
Anacy_3523	COG0489	protein tyrosine kinase activity
Anacy_3523	COG3206	protein involved in exopolysaccharide biosynthesis
Anacy_3524	COG0745	RESPONSE REGULATOR receiver
Anacy_3526	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Anacy_3527	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Anacy_3528	COG1943	Transposase
Anacy_3530	COG0752	glycyl-tRNA synthetase alpha subunit
Anacy_3536	COG1070	Carbohydrate kinase
Anacy_3542	COG0625	glutathione transferase activity
Anacy_3546	COG0857	belongs to the CobB CobQ family
Anacy_3548	COG1215	transferase activity, transferring glycosyl groups
Anacy_3558	COG1959	2 iron, 2 sulfur cluster binding
Anacy_3559	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Anacy_3560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Anacy_3562	COG0784	Response regulator, receiver
Anacy_3563	COG4251	negative regulation of phosphorylation
Anacy_3565	COG0314	molybdopterin synthase activity
Anacy_3568	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Anacy_3581	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Anacy_3588	COG1012	belongs to the aldehyde dehydrogenase family
Anacy_3596	COG1830	Aldolase
Anacy_3598	COG2267	carboxylic ester hydrolase activity
Anacy_3600	COG0668	transmembrane transport
Anacy_3601	COG0123	including yeast histone deacetylase and acetoin utilization protein
Anacy_3608	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Anacy_3613	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anacy_3614	COG0438	transferase activity, transferring glycosyl groups
Anacy_3616	COG1215	transferase activity, transferring glycosyl groups
Anacy_3618	COG1192	Involved in chromosome partitioning
Anacy_3619	COG1192	Involved in chromosome partitioning
Anacy_3621	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Anacy_3630	COG0587	DNA-directed DNA polymerase activity
Anacy_3633	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Anacy_3633	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Anacy_3635	COG0596	Alpha beta hydrolase
Anacy_3640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Anacy_3641	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Anacy_3643	COG0505	Belongs to the CarA family
Anacy_3647	COG0784	Response regulator, receiver
Anacy_3647	COG5002	protein histidine kinase activity
Anacy_3648	COG0328	RNA-DNA hybrid ribonuclease activity
Anacy_3651	COG1040	competence protein
Anacy_3653	COG1196	nuclear chromosome segregation
Anacy_3669	COG0438	transferase activity, transferring glycosyl groups
Anacy_3673	COG0492	ferredoxin-NADP+ reductase activity
Anacy_3682	COG4251	negative regulation of phosphorylation
Anacy_3688	COG0739	heme binding
Anacy_3691	COG0358	DNA primase activity
Anacy_3694	COG0784	Response regulator, receiver
Anacy_3695	COG4251	negative regulation of phosphorylation
Anacy_3696	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Anacy_3697	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Anacy_3705	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Anacy_3709	COG4245	von Willebrand factor, type A
Anacy_3711	COG0512	Glutamine amidotransferase of anthranilate synthase
Anacy_3711	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Anacy_3716	COG0534	Mate efflux family protein
Anacy_3718	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Anacy_3719	COG1605	Chorismate mutase
Anacy_3719	COG0077	Prephenate dehydratase
Anacy_3725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Anacy_3730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Anacy_3735	COG1429	ligase activity, forming nitrogen-metal bonds
Anacy_3740	COG0811	peptide transport
Anacy_3741	COG0848	biopolymer transport protein
Anacy_3742	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Anacy_3743	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Anacy_3744	COG1120	ATPase activity
Anacy_3750	COG0675	Transposase, IS605 OrfB family
Anacy_3753	COG0811	peptide transport
Anacy_3754	COG0848	biopolymer transport protein
Anacy_3759	COG0408	coproporphyrinogen oxidase activity
Anacy_3761	COG0489	protein tyrosine kinase activity
Anacy_3762	COG0772	Belongs to the SEDS family
Anacy_3765	COG0589	response to stress
Anacy_3765	COG0475	glutathione-regulated potassium exporter activity
Anacy_3766	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anacy_3767	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Anacy_3769	COG0489	protein tyrosine kinase activity
Anacy_3772	COG0438	transferase activity, transferring glycosyl groups
Anacy_3777	COG2273	Hydrolase Family 16
Anacy_3777	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Anacy_3779	COG0110	maltose O-acetyltransferase activity
Anacy_3781	COG0463	Glycosyl transferase, family 2
Anacy_3782	COG2327	Polysaccharide pyruvyl transferase
Anacy_3785	COG0438	transferase activity, transferring glycosyl groups
Anacy_3789	COG1215	transferase activity, transferring glycosyl groups
Anacy_3792	COG0529	Catalyzes the synthesis of activated sulfate
Anacy_3796	COG1546	Belongs to the CinA family
Anacy_3796	COG1058	Belongs to the CinA family
Anacy_3797	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Anacy_3798	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Anacy_3802	COG0360	Binds together with S18 to 16S ribosomal RNA
Anacy_3805	COG0586	Pfam SNARE associated Golgi protein
Anacy_3812	COG1216	Glycosyl transferase, family 2
Anacy_3822	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Anacy_3823	COG4636	protein conserved in cyanobacteria
Anacy_3824	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Anacy_3826	COG0463	Glycosyl transferase, family 2
Anacy_3827	COG2814	Major facilitator Superfamily
Anacy_3831	COG2204	response regulator
Anacy_3842	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Anacy_3844	COG5398	heme oxygenase
Anacy_3845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Anacy_3847	COG0438	transferase activity, transferring glycosyl groups
Anacy_3849	COG0438	transferase activity, transferring glycosyl groups
Anacy_3850	COG0438	transferase activity, transferring glycosyl groups
Anacy_3851	COG0450	alkyl hydroperoxide reductase
Anacy_3863	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Anacy_3864	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Anacy_3871	COG0354	folic acid binding
Anacy_3874	COG1562	ergosterol biosynthetic process
Anacy_3875	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Anacy_3875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Anacy_3876	COG1472	Belongs to the glycosyl hydrolase 3 family
Anacy_3878	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Anacy_3880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Anacy_3881	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Anacy_3884	COG1662	PFAM IS1 transposase
Anacy_3886	COG3706	GGDEF domain
Anacy_3886	COG2203	Gaf domain
Anacy_3886	COG5001	Diguanylate cyclase
Anacy_3886	COG4251	negative regulation of phosphorylation
Anacy_3887	COG2205	protein histidine kinase activity
Anacy_3887	COG0784	Response regulator, receiver
Anacy_3890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Anacy_3899	COG0330	HflC and HflK could
Anacy_3901	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Anacy_3902	COG0047	phosphoribosylformylglycinamidine synthase activity
Anacy_3906	COG0515	serine threonine protein kinase
Anacy_3908	COG1381	Involved in DNA repair and RecF pathway recombination
Anacy_3910	COG0438	transferase activity, transferring glycosyl groups
Anacy_3912	COG0488	(ABC) transporter
Anacy_3913	COG0475	glutathione-regulated potassium exporter activity
Anacy_3919	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Anacy_3920	COG0088	Forms part of the polypeptide exit tunnel
Anacy_3921	COG0089	rRNA binding
Anacy_3922	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Anacy_3925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Anacy_3926	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Anacy_3927	COG0255	Belongs to the universal ribosomal protein uL29 family
Anacy_3929	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Anacy_3930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Anacy_3931	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Anacy_3932	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Anacy_3933	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Anacy_3936	COG0200	Binds to the 23S rRNA
Anacy_3937	COG0201	protein transport
Anacy_3938	COG0563	adenylate kinase activity
Anacy_3944	COG0203	ribosomal protein L17
Anacy_3945	COG0101	tRNA pseudouridine synthase activity
Anacy_3948	COG0254	rRNA binding
Anacy_3953	COG1002	Type II restriction enzyme, methylase subunits
Anacy_3960	COG0330	HflC and HflK could
Anacy_3962	COG0571	ribonuclease III activity
Anacy_3966	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Anacy_3967	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Anacy_3968	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Anacy_3969	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Anacy_3973	COG0438	transferase activity, transferring glycosyl groups
Anacy_3992	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Anacy_3995	COG5002	protein histidine kinase activity
Anacy_4004	COG2337	Toxic component of a toxin-antitoxin (TA) module
Anacy_4007	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Anacy_4033	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_4040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Anacy_4046	COG0799	negative regulation of ribosome biogenesis
Anacy_4047	COG0297	glycogen (starch) synthase activity
Anacy_4049	COG0602	queuosine metabolic process
Anacy_4052	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Anacy_4053	COG4597	amino acid ABC transporter
Anacy_4054	COG0765	amino acid transport
Anacy_4055	COG1126	abc transporter atp-binding protein
Anacy_4062	COG0322	excinuclease ABC activity
Anacy_4067	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anacy_4076	COG1120	ATPase activity
Anacy_4077	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Anacy_4082	COG1858	cytochrome C peroxidase
Anacy_4084	COG4771	TonB-dependent receptor
Anacy_4104	COG0535	radical SAM domain protein
Anacy_4112	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Anacy_4120	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Anacy_4121	COG0519	Catalyzes the synthesis of GMP from XMP
Anacy_4121	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Anacy_4122	COG5002	protein histidine kinase activity
Anacy_4123	COG0784	Response regulator, receiver
Anacy_4124	COG4251	negative regulation of phosphorylation
Anacy_4126	COG1230	cation diffusion facilitator family transporter
Anacy_4130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Anacy_4135	COG0009	L-threonylcarbamoyladenylate synthase
Anacy_4136	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Anacy_4140	COG4636	protein conserved in cyanobacteria
Anacy_4146	COG0515	serine threonine protein kinase
Anacy_4150	COG2239	Acts as a magnesium transporter
Anacy_4155	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Anacy_4163	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Anacy_4164	COG0681	Belongs to the peptidase S26 family
Anacy_4167	COG0484	heat shock protein binding
Anacy_4169	COG2048	Heterodisulfide reductase, subunit B
Anacy_4170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anacy_4171	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Anacy_4172	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Anacy_4173	COG5002	protein histidine kinase activity
Anacy_4173	COG2205	protein histidine kinase activity
Anacy_4173	COG0784	Response regulator, receiver
Anacy_4175	COG2205	protein histidine kinase activity
Anacy_4176	COG4999	Histidine kinase
Anacy_4176	COG3850	Histidine kinase
Anacy_4176	COG2205	protein histidine kinase activity
Anacy_4176	COG3437	response regulator, receiver
Anacy_4177	COG3693	PFAM glycoside hydrolase, family 10
Anacy_4179	COG3220	belongs to the UPF0276 family
Anacy_4181	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anacy_4182	COG0590	tRNA wobble adenosine to inosine editing
Anacy_4188	COG2197	response regulator
Anacy_4189	COG4585	Histidine kinase
Anacy_4192	COG0534	Mate efflux family protein
Anacy_4194	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Anacy_4196	COG2326	polyphosphate kinase activity
Anacy_4201	COG5002	protein histidine kinase activity
Anacy_4202	COG0745	RESPONSE REGULATOR receiver
Anacy_4203	COG0745	RESPONSE REGULATOR receiver
Anacy_4206	COG0574	Belongs to the PEP-utilizing enzyme family
Anacy_4206	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Anacy_4208	COG0167	dihydroorotate dehydrogenase activity
Anacy_4232	COG0438	transferase activity, transferring glycosyl groups
Anacy_4251	COG3259	Nickel-dependent hydrogenase
Anacy_4253	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_4258	COG0589	response to stress
Anacy_4259	COG1132	(ABC) transporter
Anacy_4260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Anacy_4265	COG2226	methyltransferase
Anacy_4269	COG0811	peptide transport
Anacy_4271	COG1136	(ABC) transporter
Anacy_4274	COG1309	transcriptional regulator
Anacy_4275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anacy_4278	COG0589	response to stress
Anacy_4281	COG3852	Histidine kinase
Anacy_4282	COG3237	CsbD-like
Anacy_4283	COG3237	CsbD-like
Anacy_4287	COG0484	heat shock protein binding
Anacy_4289	COG1253	flavin adenine dinucleotide binding
Anacy_4290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Anacy_4291	COG0673	inositol 2-dehydrogenase activity
Anacy_4292	COG0586	Pfam SNARE associated Golgi protein
Anacy_4296	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Anacy_4298	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Anacy_4299	COG3781	membrane
Anacy_4300	COG2234	aminopeptidase activity
Anacy_4301	COG0443	Heat shock 70 kDa protein
Anacy_4302	COG0484	heat shock protein binding
Anacy_4305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Anacy_4306	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Anacy_4307	COG0019	diaminopimelate decarboxylase activity
Anacy_4309	COG0542	response to heat
Anacy_4313	COG0343	queuine tRNA-ribosyltransferase activity
Anacy_4317	COG0589	response to stress
Anacy_4318	COG1216	Glycosyl transferase, family 2
Anacy_4323	COG0339	signal peptide processing
Anacy_4325	COG1254	Belongs to the acylphosphatase family
Anacy_4329	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Anacy_4330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Anacy_4330	COG0189	ligase activity
Anacy_4332	COG2091	lysine biosynthetic process via aminoadipic acid
Anacy_4333	COG0429	hydrolase of the alpha beta-hydrolase fold
Anacy_4334	COG0745	RESPONSE REGULATOR receiver
Anacy_4337	COG2442	InterPro IPR007367
Anacy_4351	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Anacy_4352	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Anacy_4353	COG0443	Heat shock 70 kDa protein
Anacy_4354	COG0484	heat shock protein binding
Anacy_4356	COG1162	GTPase activity
Anacy_4357	COG1543	Belongs to the glycosyl hydrolase 57 family
Anacy_4360	COG2815	serine threonine protein kinase
Anacy_4360	COG0515	serine threonine protein kinase
Anacy_4361	COG1253	flavin adenine dinucleotide binding
Anacy_4366	COG2066	Belongs to the glutaminase family
Anacy_4373	COG1214	PFAM Peptidase M22, glycoprotease
Anacy_4375	COG0617	tRNA 3'-terminal CCA addition
Anacy_4376	COG2205	protein histidine kinase activity
Anacy_4376	COG0784	Response regulator, receiver
Anacy_4378	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Anacy_4378	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Anacy_4381	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Anacy_4382	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Anacy_4384	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_4388	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Anacy_4392	COG5002	protein histidine kinase activity
Anacy_4394	COG2205	protein histidine kinase activity
Anacy_4397	COG1175	transmembrane transport
Anacy_4400	COG4251	negative regulation of phosphorylation
Anacy_4400	COG3706	GGDEF domain
Anacy_4400	COG2203	Gaf domain
Anacy_4400	COG5001	Diguanylate cyclase
Anacy_4404	COG3956	TIGRFAM MazG family protein
Anacy_4405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Anacy_4411	COG0025	NhaP-type Na H and K H
Anacy_4413	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Anacy_4416	COG1169	isochorismate synthase
Anacy_4417	COG1575	Belongs to the MenA family. Type 1 subfamily
Anacy_4419	COG0318	PFAM AMP-dependent synthetase and ligase
Anacy_4420	COG0824	Thioesterase
Anacy_4432	COG0606	chelatase, subunit chli
Anacy_4434	COG0632	four-way junction helicase activity
Anacy_4435	COG0156	8-amino-7-oxononanoate synthase activity
Anacy_4436	COG0004	ammonium transporteR
Anacy_4437	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Anacy_4438	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Anacy_4440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Anacy_4449	COG0612	Peptidase, M16
Anacy_4452	COG1201	RNA secondary structure unwinding
Anacy_4453	COG0515	serine threonine protein kinase
Anacy_4453	COG3266	domain, Protein
Anacy_4458	COG3848	Pyruvate phosphate dikinase
Anacy_4458	COG0574	Belongs to the PEP-utilizing enzyme family
Anacy_4459	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_4460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Anacy_4461	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_4461	COG1116	anion transmembrane transporter activity
Anacy_4462	COG1116	anion transmembrane transporter activity
Anacy_4463	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_4464	COG0501	Belongs to the peptidase M48B family
Anacy_4471	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Anacy_4478	COG0577	efflux transmembrane transporter activity
Anacy_4478	COG1136	(ABC) transporter
Anacy_4489	COG0424	maF-like protein
Anacy_4493	COG4638	Rieske (2fe-2S)
Anacy_4495	COG0095	Lipoate-protein ligase
Anacy_4496	COG0138	bifunctional purine biosynthesis protein purh
Anacy_4505	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Anacy_4510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Anacy_4511	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Anacy_4512	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Anacy_4518	COG1960	acyl-CoA dehydrogenase activity
Anacy_4519	COG3321	synthase
Anacy_4519	COG0300	oxidoreductase activity
Anacy_4519	COG4221	oxidoreductase activity
Anacy_4519	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anacy_4520	COG1696	Membrane protein involved in D-alanine export
Anacy_4522	COG1252	NADH dehydrogenase
Anacy_4524	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Anacy_4526	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anacy_4529	COG2852	Protein conserved in bacteria
Anacy_4534	COG3852	Histidine kinase
Anacy_4535	COG0351	phosphomethylpyrimidine kinase
Anacy_4544	COG0564	pseudouridine synthase activity
Anacy_4545	COG3852	Histidine kinase
Anacy_4554	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Anacy_4557	COG0438	transferase activity, transferring glycosyl groups
Anacy_4558	COG1177	transmembrane transport
Anacy_4560	COG0745	RESPONSE REGULATOR receiver
Anacy_4561	COG0745	RESPONSE REGULATOR receiver
Anacy_4563	COG0784	Response regulator, receiver
Anacy_4564	COG4251	negative regulation of phosphorylation
Anacy_4569	COG4689	acetoacetate decarboxylase
Anacy_4574	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Anacy_4575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Anacy_4576	COG0515	serine threonine protein kinase
Anacy_4577	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Anacy_4579	COG1473	amidohydrolase
Anacy_4582	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Anacy_4588	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Anacy_4589	COG1253	flavin adenine dinucleotide binding
Anacy_4596	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
Anacy_4604	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Anacy_4604	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Anacy_4607	COG1836	PFAM Integral membrane protein DUF92
Anacy_4614	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Anacy_4614	COG2022	thiamine diphosphate biosynthetic process
Anacy_4615	COG0445	tRNA wobble uridine modification
Anacy_4620	COG0788	formyltetrahydrofolate deformylase activity
Anacy_4624	COG1131	(ABC) transporter
Anacy_4628	COG0352	thiamine-phosphate diphosphorylase activity
Anacy_4632	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Anacy_4633	COG0515	serine threonine protein kinase
Anacy_4634	COG0616	signal peptide processing
Anacy_4635	COG1304	FMN binding
Anacy_4640	COG3852	Histidine kinase
Anacy_4641	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Anacy_4642	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_4642	COG0515	serine threonine protein kinase
Anacy_4643	COG0515	serine threonine protein kinase
Anacy_4643	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_4648	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Anacy_4649	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Anacy_4651	COG1116	anion transmembrane transporter activity
Anacy_4652	COG1116	anion transmembrane transporter activity
Anacy_4652	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anacy_4653	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Anacy_4654	COG0784	Response regulator, receiver
Anacy_4654	COG5002	protein histidine kinase activity
Anacy_4655	COG0571	ribonuclease III activity
Anacy_4661	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Anacy_4661	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Anacy_4667	COG0670	Belongs to the BI1 family
Anacy_4670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Anacy_4671	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Anacy_4672	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Anacy_4672	COG0512	Glutamine amidotransferase of anthranilate synthase
Anacy_4678	COG0006	proline dipeptidase activity
Anacy_4681	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Anacy_4682	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Anacy_4683	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Anacy_4685	COG2319	Wd-40 repeat
Anacy_4685	COG4249	Peptidase C14 caspase catalytic subunit p20
Anacy_4686	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Anacy_4688	COG0644	oxidoreductase
Anacy_4699	COG2226	methyltransferase
Anacy_4700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Anacy_4702	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Anacy_4704	COG3852	Histidine kinase
Anacy_4706	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Anacy_4710	COG1950	PFAM Membrane protein of
Anacy_4712	COG0612	Peptidase, M16
Anacy_4713	COG0612	Peptidase, M16
Anacy_4714	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Anacy_4717	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Anacy_4718	COG0784	Response regulator, receiver
Anacy_4718	COG2205	protein histidine kinase activity
Anacy_4718	COG5002	protein histidine kinase activity
Anacy_4721	COG0175	sulfate reduction
Anacy_4723	COG0321	lipoyl(octanoyl) transferase activity
Anacy_4725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Anacy_4726	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Anacy_4731	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Anacy_4735	COG0768	penicillin binding
Anacy_4740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Anacy_4744	COG0748	coenzyme F420 binding
Anacy_4750	COG2197	response regulator
Anacy_4752	COG3854	ATPases associated with a variety of cellular activities
Anacy_4754	COG0459	protein refolding
Anacy_4755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Anacy_4756	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_4760	COG1773	rubredoxin
Anacy_4760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Anacy_4762	COG0438	transferase activity, transferring glycosyl groups
Anacy_4773	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
Anacy_4775	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Anacy_4777	COG3239	Fatty acid desaturase
Anacy_4778	COG3239	Fatty acid desaturase
Anacy_4782	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Anacy_4784	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Anacy_4788	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_4788	COG0515	serine threonine protein kinase
Anacy_4790	COG1940	carbohydrate kinase activity
Anacy_4795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Anacy_4797	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Anacy_4800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Anacy_4801	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Anacy_4802	COG1845	cytochrome c oxidase, subunit III
Anacy_4808	COG1480	7TM receptor with intracellular HD hydrolase
Anacy_4810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Anacy_4812	COG1754	DNA topoisomerase type I activity
Anacy_4812	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Anacy_4819	COG0745	RESPONSE REGULATOR receiver
Anacy_4820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Anacy_4825	COG1606	tRNA processing
Anacy_4830	COG3852	Histidine kinase
Anacy_4832	COG0758	DNA mediated transformation
Anacy_4832	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Anacy_4835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Anacy_4837	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anacy_4845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Anacy_4846	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Anacy_4847	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Anacy_4853	COG4636	protein conserved in cyanobacteria
Anacy_4859	COG0419	ATPase involved in DNA repair
Anacy_4862	COG2223	nitrite transmembrane transporter activity
Anacy_4865	COG0456	acetyltransferase
Anacy_4867	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Anacy_4869	COG3300	MHYT domain
Anacy_4869	COG5001	Diguanylate cyclase
Anacy_4870	COG1366	Belongs to the anti-sigma-factor antagonist family
Anacy_4870	COG2202	Pas domain
Anacy_4872	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Anacy_4873	COG1968	undecaprenyl-diphosphatase activity
Anacy_4875	COG1555	photosystem II stabilization
Anacy_4876	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Anacy_4879	COG4243	Vitamin k epoxide reductase
Anacy_4880	COG0434	BtpA family
Anacy_4881	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anacy_4882	COG0513	Belongs to the DEAD box helicase family
Anacy_4891	COG0483	inositol monophosphate 1-phosphatase activity
Anacy_4897	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Anacy_4905	COG0562	UDP-galactopyranose mutase
Anacy_4907	COG1216	Glycosyl transferase, family 2
Anacy_4908	COG1215	transferase activity, transferring glycosyl groups
Anacy_4915	COG0438	transferase activity, transferring glycosyl groups
Anacy_4916	COG0469	pyruvate kinase activity
Anacy_4924	COG0616	signal peptide processing
Anacy_4926	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Anacy_4931	COG1160	GTP binding
Anacy_4932	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Anacy_4933	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Anacy_4938	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Anacy_4940	COG2226	methyltransferase
Anacy_4947	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Anacy_4948	COG2205	protein histidine kinase activity
Anacy_4948	COG0784	Response regulator, receiver
Anacy_4948	COG5002	protein histidine kinase activity
Anacy_4949	COG0745	RESPONSE REGULATOR receiver
Anacy_4951	COG0398	Pfam SNARE associated Golgi protein
Anacy_4952	COG0398	Pfam SNARE associated Golgi protein
Anacy_4960	COG0515	serine threonine protein kinase
Anacy_4961	COG0515	serine threonine protein kinase
Anacy_4961	COG3266	domain, Protein
Anacy_4963	COG1160	GTP binding
Anacy_4974	COG0584	glycerophosphoryl diester phosphodiesterase
Anacy_4980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Anacy_4983	COG1120	ATPase activity
Anacy_4992	COG0110	maltose O-acetyltransferase activity
Anacy_4994	COG1215	transferase activity, transferring glycosyl groups
Anacy_5003	COG2197	response regulator
Anacy_5005	COG1234	tRNA 3'-trailer cleavage
Anacy_5006	COG0489	protein tyrosine kinase activity
Anacy_5007	COG2385	sporulation resulting in formation of a cellular spore
Anacy_5014	COG0667	Aldo Keto reductase
Anacy_5019	COG0542	response to heat
Anacy_5022	COG1127	ABC transporter
Anacy_5026	COG0539	negative regulation of cytoplasmic translation
Anacy_5030	COG2161	toxin-antitoxin pair type II binding
Anacy_5038	COG0443	Heat shock 70 kDa protein
Anacy_5042	COG0346	lactoylglutathione lyase activity
Anacy_5043	COG0798	PFAM Bile acid sodium symporter
Anacy_5045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Anacy_5046	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Anacy_5050	COG0436	Aminotransferase
Anacy_5051	COG0371	Dehydrogenase
Anacy_5053	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anacy_5058	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Anacy_5061	COG1074	ATP-dependent DNA helicase activity
Anacy_5064	COG2204	response regulator
Anacy_5068	COG0686	Belongs to the AlaDH PNT family
Anacy_5069	COG3903	Transcriptional regulator
Anacy_5069	COG2319	Wd-40 repeat
Anacy_5071	COG0673	inositol 2-dehydrogenase activity
Anacy_5076	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Anacy_5076	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Anacy_5079	COG2119	membrane
Anacy_5093	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Anacy_5094	COG0668	transmembrane transport
Anacy_5096	COG1049	propionate catabolic process, 2-methylcitrate cycle
Anacy_5106	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_5106	COG0515	serine threonine protein kinase
Anacy_5112	COG0514	ATP-dependent DNA helicase (RecQ)
Anacy_5115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Anacy_5116	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Anacy_5117	COG1234	tRNA 3'-trailer cleavage
Anacy_5119	COG0196	riboflavin kinase activity
Anacy_5120	COG0714	Associated with various cellular activities
Anacy_5123	COG0653	protein targeting
Anacy_5127	COG0419	ATPase involved in DNA repair
Anacy_5132	COG0784	Response regulator, receiver
Anacy_5135	COG0745	RESPONSE REGULATOR receiver
Anacy_5137	COG5002	protein histidine kinase activity
Anacy_5137	COG0784	Response regulator, receiver
Anacy_5141	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Anacy_5145	COG0537	adenosine 5'-monophosphoramidase activity
Anacy_5147	COG0438	transferase activity, transferring glycosyl groups
Anacy_5148	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Anacy_5153	COG1215	transferase activity, transferring glycosyl groups
Anacy_5156	COG1619	proteins homologs of microcin C7 resistance protein MccF
Anacy_5158	COG0697	spore germination
Anacy_5167	COG0516	GMP reductase activity
Anacy_5168	COG3118	belongs to the thioredoxin family
Anacy_5173	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Anacy_5174	COG2267	carboxylic ester hydrolase activity
Anacy_5177	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Anacy_5181	COG0416	fatty acid biosynthetic process
Anacy_5183	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Anacy_5188	COG0628	permease
Anacy_5190	COG2268	Band 7 protein
Anacy_5195	COG0539	negative regulation of cytoplasmic translation
Anacy_5196	COG0412	Dienelactone hydrolase
Anacy_5197	COG2188	Transcriptional regulator
Anacy_5198	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Anacy_5202	COG1215	transferase activity, transferring glycosyl groups
Anacy_5203	COG1657	PFAM Prenyltransferase squalene oxidase
Anacy_5206	COG0113	porphobilinogen synthase activity
Anacy_5208	COG0523	cobalamin synthesis protein
Anacy_5209	COG0302	gtp cyclohydrolase
Anacy_5213	COG2003	Belongs to the UPF0758 family
Anacy_5214	COG0557	exoribonuclease II activity
Anacy_5221	COG0303	'Molybdopterin
Anacy_5222	COG0534	Mate efflux family protein
Anacy_5225	COG1982	Orn Lys Arg decarboxylase major
Anacy_5227	COG1032	radical SAM domain protein
Anacy_5239	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Anacy_5240	COG0415	Belongs to the DNA photolyase family
Anacy_5241	COG0753	catalase activity
Anacy_5244	COG0297	glycogen (starch) synthase activity
Anacy_5245	COG0181	hydroxymethylbilane synthase activity
Anacy_5246	COG3706	GGDEF domain
Anacy_5248	COG1597	lipid kinase activity
Anacy_5248	COG1803	Methylglyoxal synthase
Anacy_5250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Anacy_5255	COG0583	DNA-binding transcription factor activity
Anacy_5256	COG0129	dihydroxy-acid dehydratase activity
Anacy_5261	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Anacy_5263	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Anacy_5266	COG1487	ribonuclease activity
Anacy_5268	COG0126	phosphoglycerate kinase activity
Anacy_5269	COG0589	response to stress
Anacy_5275	COG1662	PFAM IS1 transposase
Anacy_5277	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Anacy_5278	COG4956	integral membrane protein (PIN domain superfamily)
Anacy_5279	COG0346	lactoylglutathione lyase activity
Anacy_5284	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Anacy_5286	COG0569	domain protein
Anacy_5287	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Anacy_5288	COG2226	methyltransferase
Anacy_5289	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Anacy_5291	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Anacy_5292	COG1587	Uroporphyrinogen-III synthase
Anacy_5294	COG0784	Response regulator, receiver
Anacy_5295	COG4251	negative regulation of phosphorylation
Anacy_5306	COG0515	serine threonine protein kinase
Anacy_5306	COG3266	domain, Protein
Anacy_5307	COG2319	Wd-40 repeat
Anacy_5307	COG5635	Nacht domain
Anacy_5313	COG1473	amidohydrolase
Anacy_5315	COG5592	hemerythrin HHE cation binding domain
Anacy_5316	COG1132	(ABC) transporter
Anacy_5317	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Anacy_5318	COG0678	peroxiredoxin activity
Anacy_5323	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_5326	COG0038	chloride channel
Anacy_5330	COG2010	Cytochrome c
Anacy_5332	COG0742	ribosomal rna small subunit methyltransferase
Anacy_5333	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Anacy_5334	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Anacy_5339	COG2267	carboxylic ester hydrolase activity
Anacy_5344	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Anacy_5345	COG1994	Peptidase M50
Anacy_5345	COG0517	IMP dehydrogenase activity
Anacy_5348	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Anacy_5353	COG2319	Wd-40 repeat
Anacy_5353	COG4249	Peptidase C14 caspase catalytic subunit p20
Anacy_5355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Anacy_5356	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Anacy_5358	COG0484	heat shock protein binding
Anacy_5360	COG0740	serine-type endopeptidase activity
Anacy_5363	COG0515	serine threonine protein kinase
Anacy_5363	COG3266	domain, Protein
Anacy_5364	COG2319	Wd-40 repeat
Anacy_5364	COG3903	Transcriptional regulator
Anacy_5366	COG1404	Belongs to the peptidase S8 family
Anacy_5367	COG2304	oxidoreductase activity
Anacy_5368	COG2304	oxidoreductase activity
Anacy_5373	COG0066	3-isopropylmalate dehydratase activity
Anacy_5374	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Anacy_5377	COG0071	Belongs to the small heat shock protein (HSP20) family
Anacy_5382	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Anacy_5389	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Anacy_5393	COG2130	NADP-dependent
Anacy_5394	COG0724	RNA recognition motif
Anacy_5396	COG0191	fructose-bisphosphate aldolase activity
Anacy_5398	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Anacy_5401	COG0842	Transport permease protein
Anacy_5409	COG0842	Transport permease protein
Anacy_5409	COG1129	ABC transporter
Anacy_5410	COG1131	(ABC) transporter
Anacy_5411	COG1845	cytochrome c oxidase, subunit III
Anacy_5412	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Anacy_5413	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Anacy_5416	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Anacy_5417	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Anacy_5419	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Anacy_5420	COG3852	Histidine kinase
Anacy_5421	COG0625	glutathione transferase activity
Anacy_5423	COG2207	Transcriptional regulator
Anacy_5426	COG4221	oxidoreductase activity
Anacy_5431	COG2815	serine threonine protein kinase
Anacy_5431	COG0515	serine threonine protein kinase
Anacy_5432	COG1028	Short-chain dehydrogenase reductase Sdr
Anacy_5445	COG0745	RESPONSE REGULATOR receiver
Anacy_5456	COG2226	methyltransferase
Anacy_5463	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anacy_5465	COG1169	isochorismate synthase
Anacy_5466	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Anacy_5470	COG0513	Belongs to the DEAD box helicase family
Anacy_5474	COG0312	modulator of DNA gyrase
Anacy_5476	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Anacy_5480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Anacy_5485	COG1357	PFAM Pentapeptide repeats (8 copies)
Anacy_5485	COG0515	serine threonine protein kinase
Anacy_5487	COG0601	transmembrane transport
Anacy_5495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Anacy_5496	COG0573	inorganic phosphate transmembrane transporter activity
Anacy_5497	COG0581	inorganic phosphate transmembrane transporter activity
Anacy_5498	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_5527	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Anacy_5532	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Anacy_5532	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Anacy_5533	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Anacy_5536	COG3631	Ketosteroid isomerase-related protein
Anacy_5537	COG1446	asparaginase
Anacy_5540	COG0167	dihydroorotate dehydrogenase activity
Anacy_5543	COG2304	oxidoreductase activity
Anacy_5553	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Anacy_5556	COG4636	protein conserved in cyanobacteria
Anacy_5559	COG0017	Asparaginyl-tRNA synthetase
Anacy_5563	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Anacy_5565	COG0829	nickel cation binding
Anacy_5566	COG0831	urea catabolic process
Anacy_5567	COG0832	Belongs to the urease beta subunit family
Anacy_5572	COG1012	belongs to the aldehyde dehydrogenase family
Anacy_5575	COG0740	serine-type endopeptidase activity
Anacy_5576	COG0544	peptidyl-prolyl cis-trans isomerase activity
Anacy_5577	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Anacy_5578	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Anacy_5579	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Anacy_5583	COG1193	negative regulation of DNA recombination
Anacy_5591	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Anacy_5592	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Anacy_5593	COG0010	Belongs to the arginase family
Anacy_5600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Anacy_5601	COG3338	carbonate dehydratase activity
Anacy_5605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Anacy_5611	COG0717	Belongs to the dCTP deaminase family
Anacy_5616	COG5001	Diguanylate cyclase
Anacy_5616	COG4251	negative regulation of phosphorylation
Anacy_5616	COG3706	GGDEF domain
Anacy_5616	COG2203	Gaf domain
Anacy_5622	COG0318	PFAM AMP-dependent synthetase and ligase
Anacy_5623	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Anacy_5624	COG1461	Dihydroxyacetone kinase
Anacy_5625	COG2376	Dihydroxyacetone kinase
Anacy_5626	COG0242	peptide deformylase activity
Anacy_5627	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anacy_5641	COG1205	dead DEAH box helicase
Anacy_5641	COG1111	helicase
Anacy_5647	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Anacy_5649	COG0592	DNA-directed DNA polymerase activity
Anacy_5651	COG4689	acetoacetate decarboxylase
Anacy_5674	COG1662	PFAM IS1 transposase
Anacy_5695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anacy_5702	COG2205	protein histidine kinase activity
Anacy_5702	COG0784	Response regulator, receiver
Anacy_5703	COG2197	response regulator
Anacy_5709	COG0457	Tetratricopeptide repeat
Anacy_5710	COG1233	COG1233 Phytoene dehydrogenase and related
Anacy_5714	COG1598	PFAM Uncharacterised protein family UPF0150
Anacy_5746	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anacy_5763	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Anacy_5782	COG4974	Belongs to the 'phage' integrase family
Anacy_5783	COG3228	Belongs to the MtfA family
Anacy_5785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Anacy_5792	COG5002	protein histidine kinase activity
Anacy_5793	COG0745	RESPONSE REGULATOR receiver
Anacy_5795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Anacy_5805	COG5002	protein histidine kinase activity
Anacy_5807	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anacy_5810	COG1993	acr, cog1993
Anacy_5815	COG3659	wide pore channel activity
Anacy_5823	COG5002	protein histidine kinase activity
Anacy_5828	COG2217	Heavy metal translocating P-type atpase
Anacy_5830	COG2814	Major facilitator Superfamily
Anacy_5836	COG2197	response regulator
Anacy_5844	COG1695	Transcriptional regulator
Anacy_5858	COG3831	ATPase activity
Anacy_5867	COG0640	Transcriptional regulator
Anacy_5870	COG1475	DNA binding
Anacy_5876	COG0470	DNA polymerase III
Anacy_5883	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Anacy_5884	COG0592	DNA-directed DNA polymerase activity
Anacy_5897	COG1337	RAMP superfamily
Anacy_5924	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anacy_5926	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Anacy_5936	COG2226	methyltransferase
Anacy_5941	COG2217	Heavy metal translocating P-type atpase
Anacy_5942	COG1192	Involved in chromosome partitioning
Anacy_5968	COG1518	maintenance of DNA repeat elements
Anacy_5968	COG1468	defense response to virus
Anacy_5979	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Anacy_5982	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Anacy_5987	COG0714	Associated with various cellular activities
Anacy_6028	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_6051	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Anacy_6053	COG4636	protein conserved in cyanobacteria
Anacy_6054	COG0732	type I restriction modification DNA specificity domain
Anacy_6058	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Anacy_6066	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anacy_6068	COG4249	Peptidase C14 caspase catalytic subunit p20
Anacy_6068	COG2319	Wd-40 repeat
Anacy_6078	COG2319	Wd-40 repeat
Anacy_6078	COG3903	Transcriptional regulator
Anacy_6083	COG1475	DNA binding
Anacy_6091	COG4644	lycopene metabolic process
Anacy_6094	COG0443	Heat shock 70 kDa protein
Anacy_6111	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Anacy_6114	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Anacy_6117	COG1192	Involved in chromosome partitioning
Anacy_6118	COG1475	DNA binding
Anacy_6119	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Anacy_6119	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Anacy_6135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity