locus-tag	class	description
ANA_C10001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANA_C10014	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ANA_C10015	COG0668	transmembrane transport
ANA_C10019	COG0784	Response regulator, receiver
ANA_C10020	COG4245	von Willebrand factor, type A
ANA_C10023	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANA_C10024	COG0579	oxidoreductase
ANA_C10025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ANA_C10026	COG1216	Glycosyl transferase, family 2
ANA_C10027	COG1216	Glycosyl transferase, family 2
ANA_C10032	COG0489	protein tyrosine kinase activity
ANA_C10035	COG1132	(ABC) transporter
ANA_C10037	COG1216	Glycosyl transferase, family 2
ANA_C10038	COG0438	transferase activity, transferring glycosyl groups
ANA_C10045	COG2319	Wd-40 repeat
ANA_C10045	COG3903	Transcriptional regulator
ANA_C10046	COG2988	succinylglutamate desuccinylase activity
ANA_C10048	COG5433	transposase activity
ANA_C10050	COG2319	Wd-40 repeat
ANA_C10052	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ANA_C10053	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANA_C10056	COG0515	serine threonine protein kinase
ANA_C10056	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C10059	COG2197	response regulator
ANA_C10060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ANA_C10062	COG5002	protein histidine kinase activity
ANA_C10065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ANA_C10075	COG0390	transport system, permease component
ANA_C10080	COG1012	belongs to the aldehyde dehydrogenase family
ANA_C10084	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ANA_C10085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ANA_C10087	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ANA_C10089	COG0740	serine-type endopeptidase activity
ANA_C10090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ANA_C10093	COG0406	alpha-ribazole phosphatase activity
ANA_C10095	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ANA_C10100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ANA_C10104	COG0802	atpase or kinase
ANA_C10106	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ANA_C10107	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ANA_C10108	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ANA_C10110	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANA_C10114	COG0426	domain, Protein
ANA_C10114	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_C10117	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_C10117	COG0426	domain, Protein
ANA_C10121	COG0724	RNA recognition motif
ANA_C10122	COG2205	protein histidine kinase activity
ANA_C10123	COG1505	serine-type exopeptidase activity
ANA_C10124	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANA_C10126	COG0051	transcription antitermination factor activity, RNA binding
ANA_C10127	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANA_C10131	COG0316	Belongs to the HesB IscA family
ANA_C10135	COG0067	glutamate synthase
ANA_C10135	COG0070	glutamate synthase
ANA_C10135	COG0069	glutamate synthase activity
ANA_C10138	COG0463	Glycosyl transferase, family 2
ANA_C10139	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANA_C10144	COG0561	phosphatase activity
ANA_C10148	COG0432	Pfam Uncharacterised protein family UPF0047
ANA_C10149	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANA_C10151	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ANA_C10159	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ANA_C10159	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ANA_C10160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ANA_C10164	COG0494	nUDIX hydrolase
ANA_C10165	COG0534	Mate efflux family protein
ANA_C10167	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ANA_C10168	COG1268	BioY protein
ANA_C10169	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ANA_C10170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ANA_C10175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ANA_C10176	COG0601	transmembrane transport
ANA_C10179	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ANA_C10193	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANA_C10196	COG0432	Pfam Uncharacterised protein family UPF0047
ANA_C10197	COG0745	RESPONSE REGULATOR receiver
ANA_C10198	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ANA_C10200	COG4232	protein-disulfide reductase activity
ANA_C10204	COG2166	iron-sulfur cluster assembly
ANA_C10207	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ANA_C10212	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ANA_C10214	COG0133	tryptophan synthase activity
ANA_C10216	COG1401	restriction endodeoxyribonuclease activity
ANA_C10218	COG0023	Translation Initiation Factor
ANA_C10229	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C10229	COG0515	serine threonine protein kinase
ANA_C10231	COG1131	(ABC) transporter
ANA_C10232	COG1672	PFAM Archaeal ATPase
ANA_C10232	COG2319	Wd-40 repeat
ANA_C10233	COG5001	Diguanylate cyclase
ANA_C10233	COG4251	negative regulation of phosphorylation
ANA_C10233	COG3706	GGDEF domain
ANA_C10233	COG2203	Gaf domain
ANA_C10235	COG1316	TRANSCRIPTIONal
ANA_C10237	COG0728	peptidoglycan biosynthetic process
ANA_C10238	COG2239	Acts as a magnesium transporter
ANA_C10243	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ANA_C10243	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ANA_C10244	COG0222	ribosome binding
ANA_C10245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ANA_C10248	COG0250	Participates in transcription elongation, termination and antitermination
ANA_C10249	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ANA_C10250	COG0335	large ribosomal subunit rRNA binding
ANA_C10258	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ANA_C10263	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANA_C10265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ANA_C10266	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ANA_C10272	COG2205	protein histidine kinase activity
ANA_C10281	COG1672	PFAM Archaeal ATPase
ANA_C10281	COG2319	Wd-40 repeat
ANA_C10287	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ANA_C10290	COG0697	spore germination
ANA_C10291	COG0306	phosphate transporter
ANA_C10292	COG2226	methyltransferase
ANA_C10295	COG0515	serine threonine protein kinase
ANA_C10295	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C10307	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C10313	COG2361	Protein of unknown function DUF86
ANA_C10317	COG0708	Exodeoxyribonuclease III
ANA_C10322	COG0824	Thioesterase
ANA_C10323	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ANA_C10324	COG0534	Mate efflux family protein
ANA_C10325	COG0416	fatty acid biosynthetic process
ANA_C10327	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANA_C10332	COG0270	DNA (cytosine-5-)-methyltransferase activity
ANA_C10338	COG2204	response regulator
ANA_C10344	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
ANA_C10357	COG0535	radical SAM domain protein
ANA_C10365	COG0339	signal peptide processing
ANA_C10368	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ANA_C10371	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANA_C10373	COG3206	protein involved in exopolysaccharide biosynthesis
ANA_C10373	COG0489	protein tyrosine kinase activity
ANA_C10376	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_C10377	COG1216	Glycosyl transferase, family 2
ANA_C10386	COG0360	Binds together with S18 to 16S ribosomal RNA
ANA_C10390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ANA_C10391	COG0606	chelatase, subunit chli
ANA_C10395	COG0537	adenosine 5'-monophosphoramidase activity
ANA_C10398	COG0724	RNA recognition motif
ANA_C10399	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ANA_C10403	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ANA_C10404	COG3794	PFAM blue (type 1) copper domain protein
ANA_C10405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANA_C10409	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANA_C10410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ANA_C10414	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ANA_C10418	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ANA_C10419	COG1160	GTP binding
ANA_C10421	COG0745	RESPONSE REGULATOR receiver
ANA_C10422	COG0429	hydrolase of the alpha beta-hydrolase fold
ANA_C10423	COG2091	lysine biosynthetic process via aminoadipic acid
ANA_C10427	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ANA_C10428	COG0047	phosphoribosylformylglycinamidine synthase activity
ANA_C10430	COG4680	protein conserved in bacteria
ANA_C10435	COG0312	modulator of DNA gyrase
ANA_C10445	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C10446	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ANA_C10447	COG0673	inositol 2-dehydrogenase activity
ANA_C10450	COG2211	Major facilitator Superfamily
ANA_C10451	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
ANA_C10452	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ANA_C10453	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_C10460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_C10462	COG1492	cobalamin metabolic process
ANA_C10465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_C10466	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C10472	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANA_C10475	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ANA_C10480	COG0395	ABC-type sugar transport system, permease component
ANA_C10483	COG3437	response regulator, receiver
ANA_C10483	COG3850	Histidine kinase
ANA_C10483	COG2205	protein histidine kinase activity
ANA_C10483	COG4999	Histidine kinase
ANA_C10484	COG3706	GGDEF domain
ANA_C10484	COG0745	RESPONSE REGULATOR receiver
ANA_C10485	COG0814	amino acid
ANA_C10489	COG0515	serine threonine protein kinase
ANA_C10489	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_C10493	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
ANA_C10496	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANA_C10497	COG0772	Belongs to the SEDS family
ANA_C10498	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ANA_C10501	COG0154	amidase activity
ANA_C10508	COG0587	DNA-directed DNA polymerase activity
ANA_C10510	COG2274	protein secretion by the type I secretion system
ANA_C10514	COG2203	Gaf domain
ANA_C10515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANA_C10520	COG2084	Dehydrogenase
ANA_C10521	COG0629	single-stranded DNA binding
ANA_C10524	COG1136	(ABC) transporter
ANA_C10524	COG0577	efflux transmembrane transporter activity
ANA_C10528	COG0564	pseudouridine synthase activity
ANA_C10532	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ANA_C10533	COG3903	Transcriptional regulator
ANA_C10533	COG2319	Wd-40 repeat
ANA_C10544	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ANA_C10545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ANA_C10551	COG1595	DNA-templated transcription, initiation
ANA_C10552	COG1376	ErfK ybiS ycfS ynhG family protein
ANA_C10552	COG1388	LysM domain
ANA_C10554	COG0741	lytic transglycosylase activity
ANA_C10554	COG0739	heme binding
ANA_C10554	COG1196	nuclear chromosome segregation
ANA_C10555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANA_C10555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANA_C10557	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ANA_C10560	COG1027	Aspartate ammonia-lyase
ANA_C10561	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_C10565	COG2890	protein-(glutamine-N5) methyltransferase activity
ANA_C10570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ANA_C10573	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ANA_C10576	COG0628	permease
ANA_C10578	COG1316	TRANSCRIPTIONal
ANA_C10580	COG0515	serine threonine protein kinase
ANA_C10580	COG3266	domain, Protein
ANA_C10581	COG2205	protein histidine kinase activity
ANA_C10588	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ANA_C10589	COG3536	Protein conserved in bacteria
ANA_C10591	COG0138	bifunctional purine biosynthesis protein purh
ANA_C10595	COG0095	Lipoate-protein ligase
ANA_C10598	COG1196	nuclear chromosome segregation
ANA_C10598	COG1674	ftsk spoiiie
ANA_C10599	COG1192	Involved in chromosome partitioning
ANA_C10604	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ANA_C10606	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ANA_C10615	COG3258	Cytochrome c
ANA_C10616	COG0363	glucosamine-6-phosphate deaminase activity
ANA_C10617	COG1136	(ABC) transporter
ANA_C10617	COG0577	efflux transmembrane transporter activity
ANA_C10621	COG0604	alcohol dehydrogenase
ANA_C10621	COG3321	synthase
ANA_C10621	COG3321	synthase
ANA_C10621	COG0604	alcohol dehydrogenase
ANA_C10623	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANA_C10623	COG2070	2-Nitropropane dioxygenase
ANA_C10625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_C10625	COG3320	Male sterility
ANA_C10629	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ANA_C10630	COG1799	cell septum assembly
ANA_C10631	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ANA_C10637	COG1160	GTP binding
ANA_C10642	COG4581	dead DEAH box helicase
ANA_C10646	COG1902	pentaerythritol trinitrate reductase activity
ANA_C10647	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ANA_C10653	COG0308	aminopeptidase N
ANA_C10654	COG0768	penicillin binding
ANA_C10656	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ANA_C10657	COG1176	ABC-type spermidine putrescine transport system, permease component I
ANA_C10658	COG0673	inositol 2-dehydrogenase activity
ANA_C10660	COG0497	DNA recombination
ANA_C10661	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ANA_C10662	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANA_C10663	COG0583	DNA-binding transcription factor activity
ANA_C10667	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C10673	COG1429	ligase activity, forming nitrogen-metal bonds
ANA_C10691	COG0113	porphobilinogen synthase activity
ANA_C10694	COG0678	peroxiredoxin activity
ANA_C10700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANA_C10701	COG0166	Belongs to the GPI family
ANA_C10702	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ANA_C10707	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C10708	COG1160	GTP binding
ANA_C10710	COG5635	Nacht domain
ANA_C10710	COG2319	Wd-40 repeat
ANA_C10711	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ANA_C10713	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ANA_C10714	COG0501	Belongs to the peptidase M48B family
ANA_C10718	COG0297	glycogen (starch) synthase activity
ANA_C10723	COG3659	wide pore channel activity
ANA_C10724	COG0803	Belongs to the bacterial solute-binding protein 9 family
ANA_C10725	COG1121	(ABC) transporter
ANA_C10726	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ANA_C10729	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ANA_C10736	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ANA_C10737	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANA_C10738	COG1218	3'(2'),5'-bisphosphate nucleotidase
ANA_C10742	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_C10745	COG1116	anion transmembrane transporter activity
ANA_C10746	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ANA_C10746	COG1116	anion transmembrane transporter activity
ANA_C10748	COG0571	ribonuclease III activity
ANA_C10751	COG0515	serine threonine protein kinase
ANA_C10752	COG0538	isocitrate dehydrogenase activity
ANA_C10756	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANA_C10760	COG0505	Belongs to the CarA family
ANA_C10762	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ANA_C10763	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANA_C10765	COG0596	Alpha beta hydrolase
ANA_C10767	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ANA_C10767	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANA_C10768	COG2076	Multidrug Resistance protein
ANA_C10770	COG0129	dihydroxy-acid dehydratase activity
ANA_C10772	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANA_C10775	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ANA_C10780	COG0515	serine threonine protein kinase
ANA_C10780	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C10783	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ANA_C10787	COG1530	ribonuclease E activity
ANA_C10790	COG0077	Prephenate dehydratase
ANA_C10790	COG1605	Chorismate mutase
ANA_C10793	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ANA_C10795	COG0742	ribosomal rna small subunit methyltransferase
ANA_C10797	COG2010	Cytochrome c
ANA_C10803	COG0653	protein targeting
ANA_C10805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_C10811	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ANA_C10812	COG0438	transferase activity, transferring glycosyl groups
ANA_C10814	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ANA_C10815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANA_C10816	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ANA_C10818	COG1002	Type II restriction enzyme, methylase subunits
ANA_C10822	COG0745	RESPONSE REGULATOR receiver
ANA_C10825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ANA_C10828	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ANA_C10832	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C10833	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C10834	COG3266	domain, Protein
ANA_C10834	COG0515	serine threonine protein kinase
ANA_C10844	COG2183	response to ionizing radiation
ANA_C10849	COG1950	PFAM Membrane protein of
ANA_C10853	COG2010	Cytochrome c
ANA_C10860	COG3266	domain, Protein
ANA_C10860	COG0515	serine threonine protein kinase
ANA_C10874	COG3657	addiction module killer protein
ANA_C10887	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_C10889	COG0656	L-ascorbic acid biosynthetic process
ANA_C10891	COG0442	prolyl-tRNA aminoacylation
ANA_C10896	COG5554	nitrogen fixation
ANA_C10897	COG5554	nitrogen fixation
ANA_C10898	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANA_C10901	COG1045	serine acetyltransferase
ANA_C10904	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ANA_C10909	COG0045	succinate-CoA ligase (ADP-forming) activity
ANA_C10912	COG2217	Heavy metal translocating P-type atpase
ANA_C10913	COG0123	including yeast histone deacetylase and acetoin utilization protein
ANA_C10916	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANA_C10919	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANA_C10921	COG0616	signal peptide processing
ANA_C10929	COG0469	pyruvate kinase activity
ANA_C10933	COG0484	heat shock protein binding
ANA_C10939	COG4636	protein conserved in cyanobacteria
ANA_C10948	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ANA_C10953	COG0398	Pfam SNARE associated Golgi protein
ANA_C10957	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ANA_C10957	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ANA_C10964	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ANA_C10967	COG0748	coenzyme F420 binding
ANA_C10970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANA_C10973	COG0181	hydroxymethylbilane synthase activity
ANA_C10975	COG0297	glycogen (starch) synthase activity
ANA_C10978	COG4178	(ABC) transporter
ANA_C10979	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANA_C10982	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ANA_C10990	COG4948	Mandelate Racemase Muconate Lactonizing
ANA_C10995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ANA_C10999	COG3629	intracellular signal transduction
ANA_C10999	COG3903	Transcriptional regulator
ANA_C11001	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ANA_C11002	COG0745	RESPONSE REGULATOR receiver
ANA_C11005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ANA_C11007	COG3878	Protein conserved in bacteria
ANA_C11011	COG3659	wide pore channel activity
ANA_C11015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ANA_C11016	COG1408	metallophosphoesterase
ANA_C11019	COG0473	3-isopropylmalate dehydrogenase activity
ANA_C11020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANA_C11028	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANA_C11029	COG4178	(ABC) transporter
ANA_C11031	COG0436	Aminotransferase
ANA_C11032	COG0457	Tetratricopeptide repeat
ANA_C11032	COG0463	Glycosyl transferase, family 2
ANA_C11033	COG0322	excinuclease ABC activity
ANA_C11037	COG0837	glucose binding
ANA_C11046	COG1252	NADH dehydrogenase
ANA_C11047	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ANA_C11049	COG0154	amidase activity
ANA_C11052	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ANA_C11066	COG0784	Response regulator, receiver
ANA_C11067	COG0564	pseudouridine synthase activity
ANA_C11070	COG0237	dephospho-CoA kinase activity
ANA_C11071	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ANA_C11072	COG1413	lyase activity
ANA_C11073	COG1413	lyase activity
ANA_C11074	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANA_C11075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANA_C11077	COG0237	dephospho-CoA kinase activity
ANA_C11080	COG0121	glutamine amidotransferase
ANA_C11081	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ANA_C11082	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ANA_C11083	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ANA_C11084	COG4208	sulfate ABC transporter
ANA_C11088	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANA_C11090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ANA_C11091	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ANA_C11093	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANA_C11093	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ANA_C11096	COG1940	carbohydrate kinase activity
ANA_C11102	COG2082	Precorrin-8x methylmutase
ANA_C11105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ANA_C11111	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_C11111	COG0515	serine threonine protein kinase
ANA_C11118	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANA_C11123	COG3118	belongs to the thioredoxin family
ANA_C11124	COG0516	GMP reductase activity
ANA_C11130	COG0628	permease
ANA_C11138	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C11138	COG0515	serine threonine protein kinase
ANA_C11143	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ANA_C11144	COG0512	Glutamine amidotransferase of anthranilate synthase
ANA_C11145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ANA_C11147	COG0006	proline dipeptidase activity
ANA_C11148	COG5635	Nacht domain
ANA_C11148	COG2319	Wd-40 repeat
ANA_C11149	COG0454	-acetyltransferase
ANA_C11151	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ANA_C11156	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ANA_C11159	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ANA_C11162	COG0714	Associated with various cellular activities
ANA_C11172	COG0322	excinuclease ABC activity
ANA_C11174	COG0215	cysteine-tRNA ligase activity
ANA_C11175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ANA_C11176	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_C11179	COG0359	binds to the 23S rRNA
ANA_C11180	COG1372	Participates in initiation and elongation during chromosome replication
ANA_C11180	COG0305	Participates in initiation and elongation during chromosome replication
ANA_C11189	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C11193	COG0515	serine threonine protein kinase
ANA_C11194	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ANA_C11195	COG1121	(ABC) transporter
ANA_C11196	COG0803	Belongs to the bacterial solute-binding protein 9 family
ANA_C11197	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ANA_C11198	COG5398	heme oxygenase
ANA_C11199	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANA_C11202	COG1994	Peptidase M50
ANA_C11202	COG0517	IMP dehydrogenase activity
ANA_C11206	COG0302	gtp cyclohydrolase
ANA_C11207	COG0300	oxidoreductase activity
ANA_C11208	COG0825	malonyl-CoA metabolic process
ANA_C11209	COG5322	oxidoreductase activity
ANA_C11210	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ANA_C11217	COG2154	pterin-4-alpha-carbinolamine dehydratase
ANA_C11222	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ANA_C11228	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ANA_C11230	COG0683	leucine binding
ANA_C11234	COG0586	Pfam SNARE associated Golgi protein
ANA_C11235	COG1132	(ABC) transporter
ANA_C11241	COG0254	rRNA binding
ANA_C11242	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ANA_C11244	COG0101	tRNA pseudouridine synthase activity
ANA_C11245	COG0203	ribosomal protein L17
ANA_C11249	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ANA_C11251	COG0563	adenylate kinase activity
ANA_C11252	COG0201	protein transport
ANA_C11257	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ANA_C11258	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ANA_C11259	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ANA_C11260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ANA_C11263	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ANA_C11264	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ANA_C11267	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ANA_C11268	COG0089	rRNA binding
ANA_C11269	COG0088	Forms part of the polypeptide exit tunnel
ANA_C11270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ANA_C11275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANA_C11279	COG0617	tRNA 3'-terminal CCA addition
ANA_C11283	COG3937	granule-associated protein
ANA_C11284	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_C11285	COG0631	protein serine/threonine phosphatase activity
ANA_C11289	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANA_C11291	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANA_C11297	COG0438	transferase activity, transferring glycosyl groups
ANA_C11298	COG3631	Ketosteroid isomerase-related protein
ANA_C11303	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ANA_C11307	COG0539	negative regulation of cytoplasmic translation
ANA_C11308	COG0412	Dienelactone hydrolase
ANA_C11309	COG2188	Transcriptional regulator
ANA_C11311	COG0483	inositol monophosphate 1-phosphatase activity
ANA_C11313	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANA_C11319	COG0352	thiamine-phosphate diphosphorylase activity
ANA_C11326	COG0501	Belongs to the peptidase M48B family
ANA_C11327	COG0464	growth
ANA_C11328	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANA_C11337	COG1850	ribulose-bisphosphate carboxylase activity
ANA_C11339	COG4451	ribulose bisphosphate carboxylase, small
ANA_C11352	COG0438	transferase activity, transferring glycosyl groups
ANA_C11353	COG1177	transmembrane transport
ANA_C11357	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANA_C11368	COG0284	orotidine-5'-phosphate decarboxylase activity
ANA_C11368	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ANA_C11369	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANA_C11370	COG1104	cysteine desulfurase activity
ANA_C11374	COG0312	modulator of DNA gyrase
ANA_C11375	COG0312	modulator of DNA gyrase
ANA_C11381	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ANA_C11382	COG0009	L-threonylcarbamoyladenylate synthase
ANA_C11391	COG2176	DNA-directed DNA polymerase activity
ANA_C11396	COG0463	Glycosyl transferase, family 2
ANA_C11401	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ANA_C11404	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ANA_C11406	COG0113	porphobilinogen synthase activity
ANA_C11407	COG0523	cobalamin synthesis protein
ANA_C11408	COG0302	gtp cyclohydrolase
ANA_C11414	COG0408	coproporphyrinogen oxidase activity
ANA_C11423	COG0582	viral genome integration into host DNA
ANA_C11425	COG1943	Transposase
ANA_C11440	COG2501	S4 domain
ANA_C11442	COG0746	molybdenum cofactor guanylyltransferase activity
ANA_C11450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ANA_C11456	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ANA_C11458	COG2226	methyltransferase
ANA_C11460	COG0375	protein maturation
ANA_C11463	COG0409	Hydrogenase expression formation protein
ANA_C11464	COG0298	carbon dioxide binding
ANA_C11465	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ANA_C11479	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_C11480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANA_C11485	COG0563	adenylate kinase activity
ANA_C11486	COG3118	belongs to the thioredoxin family
ANA_C11490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ANA_C11491	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ANA_C11494	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ANA_C11498	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_C11502	COG0004	ammonium transporteR
ANA_C11504	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ANA_C11506	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C11507	COG1937	Protein conserved in bacteria
ANA_C11511	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ANA_C11516	COG0024	Methionine aminopeptidase
ANA_C11517	COG0673	inositol 2-dehydrogenase activity
ANA_C11522	COG2385	sporulation resulting in formation of a cellular spore
ANA_C11524	COG1366	Belongs to the anti-sigma-factor antagonist family
ANA_C11525	COG0745	RESPONSE REGULATOR receiver
ANA_C11532	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C11534	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C11534	COG0515	serine threonine protein kinase
ANA_C11535	COG1366	Belongs to the anti-sigma-factor antagonist family
ANA_C11536	COG0586	Pfam SNARE associated Golgi protein
ANA_C11539	COG0752	glycyl-tRNA synthetase alpha subunit
ANA_C11543	COG1819	glycosyl
ANA_C11544	COG2124	cytochrome p450
ANA_C11549	COG2267	carboxylic ester hydrolase activity
ANA_C11551	COG0515	serine threonine protein kinase
ANA_C11551	COG3266	domain, Protein
ANA_C11552	COG0515	serine threonine protein kinase
ANA_C11552	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C11553	COG1073	alpha beta
ANA_C11554	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
ANA_C11555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ANA_C11559	COG0515	serine threonine protein kinase
ANA_C11559	COG3266	domain, Protein
ANA_C11564	COG0024	Methionine aminopeptidase
ANA_C11566	COG0612	Peptidase, M16
ANA_C11572	COG0285	dihydrofolate synthase activity
ANA_C11579	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ANA_C11580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ANA_C11581	COG1959	2 iron, 2 sulfur cluster binding
ANA_C11585	COG0038	chloride channel
ANA_C11587	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANA_C11591	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ANA_C11592	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ANA_C11595	COG1872	DUF167
ANA_C11602	COG1473	amidohydrolase
ANA_C11607	COG1136	(ABC) transporter
ANA_C11609	COG0303	'Molybdopterin
ANA_C11611	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_C11617	COG2831	hemolysin activation secretion protein
ANA_C11622	COG0513	Belongs to the DEAD box helicase family
ANA_C11625	COG0592	DNA-directed DNA polymerase activity
ANA_C11626	COG2010	Cytochrome c
ANA_C11638	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ANA_C11641	COG1051	belongs to the nudix hydrolase family
ANA_C11642	COG0628	permease
ANA_C11646	COG1979	alcohol dehydrogenase
ANA_C11647	COG0151	Belongs to the GarS family
ANA_C11652	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ANA_C11667	COG0793	Belongs to the peptidase S41A family
ANA_C11671	COG0850	regulation of cytokinetic process
ANA_C11672	COG2894	cell division
ANA_C11673	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ANA_C11674	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANA_C11681	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ANA_C11685	COG2385	sporulation resulting in formation of a cellular spore
ANA_C11686	COG0489	protein tyrosine kinase activity
ANA_C11687	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANA_C11689	COG1252	NADH dehydrogenase
ANA_C11691	COG1404	Belongs to the peptidase S8 family
ANA_C11691	COG4935	Belongs to the peptidase S8 family
ANA_C11696	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANA_C11697	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ANA_C11698	COG4597	amino acid ABC transporter
ANA_C11704	COG0765	amino acid transport
ANA_C11705	COG1126	abc transporter atp-binding protein
ANA_C11708	COG0523	cobalamin synthesis protein
ANA_C11711	COG0517	IMP dehydrogenase activity
ANA_C11711	COG1125	glycine betaine transport
ANA_C11718	COG5002	protein histidine kinase activity
ANA_C11720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ANA_C11722	COG1587	Uroporphyrinogen-III synthase
ANA_C11723	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ANA_C11724	COG0745	RESPONSE REGULATOR receiver
ANA_C11734	COG0243	molybdopterin cofactor binding
ANA_C11735	COG1032	radical SAM domain protein
ANA_C11737	COG0180	Tryptophanyl-tRNA synthetase
ANA_C11739	COG3266	domain, Protein
ANA_C11739	COG0515	serine threonine protein kinase
ANA_C11740	COG3266	domain, Protein
ANA_C11740	COG0515	serine threonine protein kinase
ANA_C11741	COG1028	Short-chain dehydrogenase reductase Sdr
ANA_C11744	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANA_C11745	COG0459	protein refolding
ANA_C11746	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ANA_C11755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_C11756	COG0573	inorganic phosphate transmembrane transporter activity
ANA_C11757	COG0581	inorganic phosphate transmembrane transporter activity
ANA_C11758	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANA_C11761	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_C11761	COG0515	serine threonine protein kinase
ANA_C11763	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_C11765	COG0581	inorganic phosphate transmembrane transporter activity
ANA_C11766	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANA_C11769	COG0629	single-stranded DNA binding
ANA_C11770	COG1077	Cell shape determining protein MreB Mrl
ANA_C11784	COG1672	PFAM Archaeal ATPase
ANA_C11784	COG2319	Wd-40 repeat
ANA_C11787	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANA_C11787	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ANA_C11790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANA_C11795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_C11799	COG4178	(ABC) transporter
ANA_C11811	COG0018	arginyl-trna synthetase
ANA_C11812	COG1193	negative regulation of DNA recombination
ANA_C11815	COG1215	transferase activity, transferring glycosyl groups
ANA_C11816	COG0463	Glycosyl transferase, family 2
ANA_C11817	COG1619	proteins homologs of microcin C7 resistance protein MccF
ANA_C11818	COG0697	spore germination
ANA_C11819	COG0314	molybdopterin synthase activity
ANA_C11821	COG0811	peptide transport
ANA_C11822	COG0848	biopolymer transport protein
ANA_C11825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ANA_C11832	COG3240	lipase activity
ANA_C11835	COG4680	protein conserved in bacteria
ANA_C11841	COG0584	glycerophosphoryl diester phosphodiesterase
ANA_C11844	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ANA_C11849	COG2124	cytochrome p450
ANA_C11858	COG2337	Toxic component of a toxin-antitoxin (TA) module
ANA_C11863	COG3609	addiction module antidote protein, CC2985 family
ANA_C11866	COG5433	transposase activity
ANA_C11873	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ANA_C11876	COG0857	belongs to the CobB CobQ family
ANA_C11890	COG1215	transferase activity, transferring glycosyl groups
ANA_C11895	COG3259	Nickel-dependent hydrogenase
ANA_C11897	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_C11901	COG0589	response to stress
ANA_C11902	COG2205	protein histidine kinase activity
ANA_C11903	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANA_C11905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ANA_C11906	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANA_C11907	COG2205	protein histidine kinase activity
ANA_C11910	COG4279	zinc finger
ANA_C11912	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANA_C11918	COG0165	Argininosuccinate lyase
ANA_C11920	COG1691	(AIR) carboxylase
ANA_C11921	COG0668	transmembrane transport
ANA_C11923	COG4166	transmembrane transport
ANA_C11928	COG0336	Belongs to the RNA methyltransferase TrmD family
ANA_C11929	COG4242	Belongs to the peptidase S51 family
ANA_C11931	COG0003	Pfam Anion-transporting ATPase
ANA_C11932	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANA_C11936	COG0316	Belongs to the HesB IscA family
ANA_C11939	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ANA_C11942	COG2203	Gaf domain
ANA_C11942	COG3706	GGDEF domain
ANA_C11942	COG4251	negative regulation of phosphorylation
ANA_C11942	COG5001	Diguanylate cyclase
ANA_C11946	COG0438	transferase activity, transferring glycosyl groups
ANA_C11950	COG0167	dihydroorotate dehydrogenase activity
ANA_C11951	COG0205	6-phosphofructokinase activity
ANA_C11955	COG0469	pyruvate kinase activity
ANA_C11956	COG0574	Belongs to the PEP-utilizing enzyme family
ANA_C11956	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANA_C11959	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ANA_C11966	COG1252	NADH dehydrogenase
ANA_C11976	COG0556	nucleotide-excision repair
ANA_C11980	COG4636	protein conserved in cyanobacteria
ANA_C11985	COG0419	ATPase involved in DNA repair
ANA_C11987	COG2223	nitrite transmembrane transporter activity
ANA_C11992	COG3706	GGDEF domain
ANA_C11992	COG2203	Gaf domain
ANA_C11992	COG5001	Diguanylate cyclase
ANA_C11992	COG4251	negative regulation of phosphorylation
ANA_C11995	COG1968	undecaprenyl-diphosphatase activity
ANA_C11996	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_C11997	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ANA_C11999	COG2267	carboxylic ester hydrolase activity
ANA_C12003	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ANA_C12004	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_C12005	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_C12007	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANA_C12017	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANA_C12027	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ANA_C12029	COG4249	Peptidase C14 caspase catalytic subunit p20
ANA_C12029	COG2319	Wd-40 repeat
ANA_C12031	COG1132	(ABC) transporter
ANA_C12032	COG0328	RNA-DNA hybrid ribonuclease activity
ANA_C12038	COG0343	queuine tRNA-ribosyltransferase activity
ANA_C12044	COG1040	competence protein
ANA_C12053	COG1666	GTP binding
ANA_C12057	COG1070	Carbohydrate kinase
ANA_C12063	COG0515	serine threonine protein kinase
ANA_C12063	COG3266	domain, Protein
ANA_C12065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ANA_C12069	COG0644	oxidoreductase
ANA_C12077	COG0523	cobalamin synthesis protein
ANA_C12096	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANA_C12101	COG0495	leucyl-tRNA aminoacylation
ANA_C12102	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_C12102	COG0515	serine threonine protein kinase
ANA_C12108	COG0003	Pfam Anion-transporting ATPase
ANA_C12112	COG1160	GTP binding
ANA_C12114	COG0066	3-isopropylmalate dehydratase activity
ANA_C12116	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ANA_C12118	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ANA_C12121	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ANA_C12122	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C12135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ANA_C12136	COG5398	heme oxygenase
ANA_C12137	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANA_C12138	COG0450	alkyl hydroperoxide reductase
ANA_C12142	COG1834	amidinotransferase
ANA_C12146	COG0515	serine threonine protein kinase
ANA_C12146	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C12150	COG1429	ligase activity, forming nitrogen-metal bonds
ANA_C12151	COG0577	efflux transmembrane transporter activity
ANA_C12151	COG1136	(ABC) transporter
ANA_C12155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANA_C12159	COG1649	PFAM Uncharacterised BCR, COG1649
ANA_C12160	COG0494	nUDIX hydrolase
ANA_C12164	COG0517	IMP dehydrogenase activity
ANA_C12164	COG0516	GMP reductase activity
ANA_C12167	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ANA_C12168	COG0330	HflC and HflK could
ANA_C12169	COG1596	polysaccharide export
ANA_C12170	COG1131	(ABC) transporter
ANA_C12171	COG0131	Imidazoleglycerol-phosphate dehydratase
ANA_C12172	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ANA_C12174	COG4372	Transposase
ANA_C12179	COG0826	peptidase U32
ANA_C12184	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANA_C12187	COG1940	carbohydrate kinase activity
ANA_C12191	COG4968	Prepilin-type N-terminal cleavage methylation domain
ANA_C12198	COG1196	nuclear chromosome segregation
ANA_C12201	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_C12206	COG1487	ribonuclease activity
ANA_C12209	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ANA_C12215	COG1253	flavin adenine dinucleotide binding
ANA_C12216	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ANA_C12223	COG0259	pyridoxamine-phosphate oxidase activity
ANA_C12225	COG0628	permease
ANA_C12227	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANA_C12228	COG1166	arginine decarboxylase activity
ANA_C12230	COG0105	UTP biosynthetic process
ANA_C12231	COG0861	Integral membrane protein TerC family
ANA_C12233	COG0745	RESPONSE REGULATOR receiver
ANA_C12236	COG0419	ATPase involved in DNA repair
ANA_C12244	COG0642	Histidine kinase
ANA_C12244	COG3850	Histidine kinase
ANA_C12255	COG2161	toxin-antitoxin pair type II binding
ANA_C12259	COG0750	zinc metalloprotease
ANA_C12260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ANA_C12261	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ANA_C12263	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ANA_C12266	COG0242	peptide deformylase activity
ANA_C12273	COG0725	ABC transporter, periplasmic molybdate-binding protein
ANA_C12274	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ANA_C12284	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_C12284	COG0426	domain, Protein
ANA_C12285	COG0426	domain, Protein
ANA_C12285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_C12286	COG4399	Belongs to the UPF0754 family
ANA_C12289	COG0515	serine threonine protein kinase
ANA_C12289	COG2815	serine threonine protein kinase
ANA_C12293	COG0210	DNA helicase
ANA_C12294	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ANA_C12298	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ANA_C12302	COG1672	PFAM Archaeal ATPase
ANA_C12302	COG2319	Wd-40 repeat
ANA_C12304	COG0572	uridine kinase
ANA_C12306	COG0460	homoserine dehydrogenase
ANA_C12308	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANA_C12318	COG1836	PFAM Integral membrane protein DUF92
ANA_C12328	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANA_C12328	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANA_C12332	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ANA_C12333	COG0148	phosphopyruvate hydratase activity
ANA_C12345	COG0346	lactoylglutathione lyase activity
ANA_C12346	COG0542	response to heat
ANA_C12355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ANA_C12360	COG5002	protein histidine kinase activity
ANA_C12362	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ANA_C12363	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ANA_C12370	COG0735	belongs to the Fur family
ANA_C12371	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_C12373	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANA_C12374	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANA_C12377	COG4804	nuclease activity
ANA_C12378	COG0732	type I restriction modification DNA specificity domain
ANA_C12388	COG1247	-acetyltransferase
ANA_C12389	COG0739	heme binding
ANA_C12390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ANA_C12391	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ANA_C12396	COG0713	ATP synthesis coupled electron transport
ANA_C12397	COG0839	Belongs to the complex I subunit 6 family
ANA_C12399	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ANA_C12400	COG0372	Belongs to the citrate synthase family
ANA_C12401	COG2062	phosphohistidine phosphatase, SixA
ANA_C12406	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ANA_C12408	COG0840	transmembrane signaling receptor activity
ANA_C12408	COG2203	Gaf domain
ANA_C12409	COG0643	Histidine kinase
ANA_C12409	COG2198	Histidine kinase
ANA_C12412	COG3639	organic phosphonate transmembrane transporter activity
ANA_C12413	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ANA_C12416	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ANA_C12417	COG0509	glycine decarboxylation via glycine cleavage system
ANA_C12421	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ANA_C12422	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANA_C12423	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANA_C12431	COG1606	tRNA processing
ANA_C12432	COG5002	protein histidine kinase activity
ANA_C12436	COG1032	radical SAM domain protein
ANA_C12437	COG5002	protein histidine kinase activity
ANA_C12437	COG3850	Histidine kinase
ANA_C12438	COG0784	Response regulator, receiver
ANA_C12439	COG4251	negative regulation of phosphorylation
ANA_C12451	COG0793	Belongs to the peptidase S41A family
ANA_C12452	COG0515	serine threonine protein kinase
ANA_C12452	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C12454	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_C12455	COG2326	polyphosphate kinase activity
ANA_C12458	COG1797	cobyrinic acid a,c-diamide synthase activity
ANA_C12465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ANA_C12470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ANA_C12471	COG0515	serine threonine protein kinase
ANA_C12471	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C12472	COG3311	Transcriptional regulator
ANA_C12474	COG1063	alcohol dehydrogenase
ANA_C12482	COG0438	transferase activity, transferring glycosyl groups
ANA_C12487	COG1086	Polysaccharide biosynthesis protein
ANA_C12490	COG1134	teichoic acid transport
ANA_C12492	COG1216	Glycosyl transferase, family 2
ANA_C12492	COG0463	Glycosyl transferase, family 2
ANA_C12493	COG0438	transferase activity, transferring glycosyl groups
ANA_C12494	COG0463	Glycosyl transferase, family 2
ANA_C12494	COG1216	Glycosyl transferase, family 2
ANA_C12496	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ANA_C12498	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANA_C12499	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ANA_C12503	COG0445	tRNA wobble uridine modification
ANA_C12507	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_C12507	COG0515	serine threonine protein kinase
ANA_C12509	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ANA_C12510	COG0751	glycine-tRNA ligase activity
ANA_C12518	COG2217	Heavy metal translocating P-type atpase
ANA_C12519	COG1090	epimerase
ANA_C12523	COG2852	Protein conserved in bacteria
ANA_C12525	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C12529	COG0450	alkyl hydroperoxide reductase
ANA_C12531	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C12538	COG1091	dTDP-4-dehydrorhamnose reductase activity
ANA_C12545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_C12546	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ANA_C12547	COG0783	Belongs to the Dps family
ANA_C12553	COG0515	serine threonine protein kinase
ANA_C12553	COG3266	domain, Protein
ANA_C12555	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_C12556	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANA_C12557	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_C12558	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_C12559	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ANA_C12560	COG4451	ribulose bisphosphate carboxylase, small
ANA_C12560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ANA_C12564	COG0745	RESPONSE REGULATOR receiver
ANA_C12570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANA_C12577	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANA_C12577	COG0758	DNA mediated transformation
ANA_C12581	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ANA_C12585	COG1234	tRNA 3'-trailer cleavage
ANA_C12586	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_C12589	COG1104	cysteine desulfurase activity
ANA_C12593	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ANA_C12594	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ANA_C12597	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ANA_C12599	COG0515	serine threonine protein kinase
ANA_C12599	COG4991	sh3 domain protein
ANA_C12599	COG3064	Membrane
ANA_C12600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ANA_C12603	COG0515	serine threonine protein kinase
ANA_C12605	COG0038	chloride channel
ANA_C12608	COG0312	modulator of DNA gyrase
ANA_C12610	COG1573	uracil-dna glycosylase
ANA_C12612	COG1058	Belongs to the CinA family
ANA_C12612	COG1546	Belongs to the CinA family
ANA_C12615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ANA_C12624	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANA_C12627	COG1215	transferase activity, transferring glycosyl groups
ANA_C12628	COG0438	transferase activity, transferring glycosyl groups
ANA_C12635	COG1696	Membrane protein involved in D-alanine export
ANA_C12637	COG0463	Glycosyl transferase, family 2
ANA_C12642	COG0438	transferase activity, transferring glycosyl groups
ANA_C12644	COG0438	transferase activity, transferring glycosyl groups
ANA_C12648	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_C12649	COG0463	Glycosyl transferase, family 2
ANA_C12654	COG0489	protein tyrosine kinase activity
ANA_C12656	COG0501	Belongs to the peptidase M48B family
ANA_C12657	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANA_C12658	COG0321	lipoyl(octanoyl) transferase activity
ANA_C12659	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ANA_C12660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_C12669	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ANA_C12672	COG0768	penicillin binding
ANA_C12677	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ANA_C12684	COG0191	fructose-bisphosphate aldolase activity
ANA_C12692	COG2226	methyltransferase
ANA_C12695	COG1045	serine acetyltransferase
ANA_C12699	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ANA_C12702	COG3977	Valine--pyruvate aminotransferase
ANA_C12703	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ANA_C12707	COG2132	Multicopper oxidase
ANA_C12711	COG0310	cobalt ion transport
ANA_C12713	COG1122	ATPase activity
ANA_C12715	COG0514	ATP-dependent DNA helicase (RecQ)
ANA_C12716	COG1446	asparaginase
ANA_C12719	COG0167	dihydroorotate dehydrogenase activity
ANA_C12722	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANA_C12722	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANA_C12727	COG0745	RESPONSE REGULATOR receiver
ANA_C12728	COG5002	protein histidine kinase activity
ANA_C12729	COG0704	Plays a role in the regulation of phosphate uptake
ANA_C12730	COG3659	wide pore channel activity
ANA_C12731	COG0277	FAD linked oxidase domain protein
ANA_C12732	COG0247	lactate metabolic process
ANA_C12734	COG2442	InterPro IPR007367
ANA_C12736	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C12736	COG0515	serine threonine protein kinase
ANA_C12737	COG0572	uridine kinase
ANA_C12738	COG2003	Belongs to the UPF0758 family
ANA_C12741	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANA_C12743	COG0384	phenazine biosynthesis protein PhzF
ANA_C12746	COG0612	Peptidase, M16
ANA_C12747	COG0612	Peptidase, M16
ANA_C12748	COG0004	ammonium transporteR
ANA_C12751	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ANA_C12752	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C12754	COG1106	Psort location Cytoplasmic, score
ANA_C12756	COG4636	protein conserved in cyanobacteria
ANA_C12765	COG1657	PFAM Prenyltransferase squalene oxidase
ANA_C12770	COG0612	Peptidase, M16
ANA_C12771	COG2226	methyltransferase
ANA_C12773	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ANA_C12778	COG0799	negative regulation of ribosome biogenesis
ANA_C12784	COG1494	fructose-1,6-bisphosphatase
ANA_C12790	COG0019	diaminopimelate decarboxylase activity
ANA_C12794	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ANA_C12794	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ANA_C12797	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANA_C12801	COG0194	GDP metabolic process
ANA_C12802	COG2052	Domain of unknown function (DUF370)
ANA_C12807	COG0142	geranyltranstransferase activity
ANA_C12809	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ANA_C12810	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANA_C12811	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANA_C12811	COG2247	cell wall binding repeat
ANA_C12812	COG0475	glutathione-regulated potassium exporter activity
ANA_C12815	COG1012	belongs to the aldehyde dehydrogenase family
ANA_C12816	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C12817	COG2059	Chromate
ANA_C12818	COG0584	glycerophosphoryl diester phosphodiesterase
ANA_C12819	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANA_C12820	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ANA_C12821	COG0310	cobalt ion transport
ANA_C12822	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
ANA_C12824	COG1122	ATPase activity
ANA_C12829	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ANA_C12834	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_C12836	COG0248	Ppx GppA phosphatase
ANA_C12837	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANA_C12839	COG2208	phosphoserine phosphatase activity
ANA_C12842	COG0552	protein localization to endoplasmic reticulum
ANA_C12843	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANA_C12845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANA_C12847	COG4221	oxidoreductase activity
ANA_C12851	COG0589	response to stress
ANA_C12852	COG0126	phosphoglycerate kinase activity
ANA_C12856	COG0515	serine threonine protein kinase
ANA_C12856	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C12861	COG4636	protein conserved in cyanobacteria
ANA_C12867	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ANA_C12870	COG2912	Transglutaminase-like superfamily
ANA_C12872	COG1160	GTP binding
ANA_C12873	COG1136	(ABC) transporter
ANA_C12874	COG1136	(ABC) transporter
ANA_C12874	COG0577	efflux transmembrane transporter activity
ANA_C12875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANA_C12881	COG0438	transferase activity, transferring glycosyl groups
ANA_C12883	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ANA_C12884	COG0546	phosphoglycolate phosphatase activity
ANA_C12885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ANA_C12887	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANA_C12888	COG0824	Thioesterase
ANA_C12889	COG0318	PFAM AMP-dependent synthetase and ligase
ANA_C12891	COG1575	Belongs to the MenA family. Type 1 subfamily
ANA_C12893	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANA_C12911	COG0003	Pfam Anion-transporting ATPase
ANA_C12913	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ANA_C12915	COG1233	COG1233 Phytoene dehydrogenase and related
ANA_C12917	COG3956	TIGRFAM MazG family protein
ANA_C12919	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANA_C12920	COG4636	protein conserved in cyanobacteria
ANA_C12926	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANA_C12928	COG0277	FAD linked oxidase domain protein
ANA_C12931	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_C12933	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ANA_C12934	COG4221	oxidoreductase activity
ANA_C12936	COG1570	exodeoxyribonuclease VII activity
ANA_C12943	COG0156	8-amino-7-oxononanoate synthase activity
ANA_C12944	COG0632	four-way junction helicase activity
ANA_C12945	COG0561	phosphatase activity
ANA_C12946	COG0561	phosphatase activity
ANA_C12956	COG1722	exodeoxyribonuclease VII activity
ANA_C12964	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C12964	COG0515	serine threonine protein kinase
ANA_C12966	COG1012	belongs to the aldehyde dehydrogenase family
ANA_C12974	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ANA_C12975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ANA_C12976	COG3409	Peptidoglycan-binding domain 1 protein
ANA_C12976	COG3429	Glucose-6-phosphate dehydrogenase subunit
ANA_C12979	COG4251	negative regulation of phosphorylation
ANA_C12981	COG1943	Transposase
ANA_C12982	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ANA_C12985	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ANA_C12992	COG2045	Belongs to the ComB family
ANA_C12993	COG2363	Small membrane protein
ANA_C12995	COG0556	nucleotide-excision repair
ANA_C12996	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ANA_C12997	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ANA_C12999	COG5433	transposase activity
ANA_C13007	COG0515	serine threonine protein kinase
ANA_C13007	COG2815	serine threonine protein kinase
ANA_C13046	COG0582	viral genome integration into host DNA
ANA_C13048	COG4178	(ABC) transporter
ANA_C13049	COG1874	Beta-galactosidase
ANA_C13049	COG0366	Alpha amylase catalytic
ANA_C13051	COG0463	Glycosyl transferase, family 2
ANA_C13054	COG0318	PFAM AMP-dependent synthetase and ligase
ANA_C13059	COG1028	Short-chain dehydrogenase reductase Sdr
ANA_C13063	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANA_C13064	COG1819	glycosyl
ANA_C13069	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ANA_C13071	COG1215	transferase activity, transferring glycosyl groups
ANA_C13075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ANA_C13076	COG0719	Fe-S assembly protein
ANA_C13077	COG0396	ATPase activity
ANA_C13078	COG0719	Fe-S assembly protein
ANA_C13086	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C13090	COG0659	secondary active sulfate transmembrane transporter activity
ANA_C13093	COG0393	Putative heavy-metal-binding
ANA_C13097	COG2197	response regulator
ANA_C13099	COG1053	succinate dehydrogenase
ANA_C13100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C13102	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C13108	COG0701	Predicted permease
ANA_C13110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C13111	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANA_C13118	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ANA_C13119	COG0830	nickel cation binding
ANA_C13120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ANA_C13124	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ANA_C13126	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ANA_C13127	COG0798	PFAM Bile acid sodium symporter
ANA_C13129	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ANA_C13130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_C13135	COG3394	polysaccharide catabolic process
ANA_C13149	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ANA_C13151	COG3706	GGDEF domain
ANA_C13151	COG0745	RESPONSE REGULATOR receiver
ANA_C13152	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ANA_C13153	COG0489	protein tyrosine kinase activity
ANA_C13157	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ANA_C13162	COG1132	(ABC) transporter
ANA_C13164	COG0463	Glycosyl transferase, family 2
ANA_C13164	COG1216	Glycosyl transferase, family 2
ANA_C13165	COG1215	transferase activity, transferring glycosyl groups
ANA_C13168	COG0438	transferase activity, transferring glycosyl groups
ANA_C13169	COG0438	transferase activity, transferring glycosyl groups
ANA_C13170	COG1216	Glycosyl transferase, family 2
ANA_C13171	COG0438	transferase activity, transferring glycosyl groups
ANA_C13178	COG1088	dTDP-glucose 4,6-dehydratase activity
ANA_C13184	COG1845	cytochrome c oxidase, subunit III
ANA_C13185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANA_C13186	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANA_C13188	COG0109	protoheme IX farnesyltransferase activity
ANA_C13190	COG1543	Belongs to the glycosyl hydrolase 57 family
ANA_C13194	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANA_C13198	COG0443	Heat shock 70 kDa protein
ANA_C13200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ANA_C13204	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANA_C13204	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANA_C13205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ANA_C13207	COG0561	phosphatase activity
ANA_C13209	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANA_C13210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_C13211	COG0515	serine threonine protein kinase
ANA_C13212	COG0583	DNA-binding transcription factor activity
ANA_C13214	COG3118	belongs to the thioredoxin family
ANA_C13215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANA_C13218	COG4636	protein conserved in cyanobacteria
ANA_C13223	COG0667	Aldo Keto reductase
ANA_C13232	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_C13233	COG1372	Participates in initiation and elongation during chromosome replication
ANA_C13233	COG0187	DNA topoisomerase II activity
ANA_C13235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ANA_C13237	COG4680	protein conserved in bacteria
ANA_C13240	COG0706	membrane insertase activity
ANA_C13243	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ANA_C13245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ANA_C13246	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ANA_C13247	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ANA_C13251	COG2337	Toxic component of a toxin-antitoxin (TA) module
ANA_C13260	COG0484	heat shock protein binding
ANA_C13261	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ANA_C13262	COG1959	2 iron, 2 sulfur cluster binding
ANA_C13263	COG3659	wide pore channel activity
ANA_C13266	COG1122	ATPase activity
ANA_C13267	COG3688	RNA-binding protein containing a PIN domain
ANA_C13268	COG4771	TonB-dependent receptor
ANA_C13278	COG3321	synthase
ANA_C13278	COG0604	alcohol dehydrogenase
ANA_C13279	COG3321	synthase
ANA_C13279	COG1028	Short-chain dehydrogenase reductase Sdr
ANA_C13279	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ANA_C13279	COG4221	oxidoreductase activity
ANA_C13281	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_C13281	COG0300	oxidoreductase activity
ANA_C13281	COG4221	oxidoreductase activity
ANA_C13281	COG3321	synthase
ANA_C13282	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANA_C13282	COG2070	2-Nitropropane dioxygenase
ANA_C13283	COG3320	Male sterility
ANA_C13283	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_C13284	COG0300	oxidoreductase activity
ANA_C13285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANA_C13289	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANA_C13290	COG0515	serine threonine protein kinase
ANA_C13294	COG0521	Mo-molybdopterin cofactor biosynthetic process
ANA_C13296	COG1785	Belongs to the alkaline phosphatase family
ANA_C13298	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ANA_C13300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_C13304	COG0525	valine-tRNA ligase activity
ANA_C13309	COG2274	protein secretion by the type I secretion system
ANA_C13319	COG1487	ribonuclease activity
ANA_C13321	COG1555	photosystem II stabilization
ANA_C13322	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ANA_C13331	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANA_C13334	COG0010	Belongs to the arginase family
ANA_C13335	COG2264	protein methyltransferase activity
ANA_C13336	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANA_C13337	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ANA_C13338	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ANA_C13347	COG0513	Belongs to the DEAD box helicase family
ANA_C13348	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANA_C13349	COG0434	BtpA family
ANA_C13350	COG4243	Vitamin k epoxide reductase
ANA_C13351	COG0542	response to heat
ANA_C13356	COG1773	rubredoxin
ANA_C13357	COG2081	HI0933 family
ANA_C13359	COG0848	biopolymer transport protein
ANA_C13360	COG0811	peptide transport
ANA_C13361	COG2226	methyltransferase
ANA_C13362	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ANA_C13365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ANA_C13366	COG3852	Histidine kinase
ANA_C13369	COG0772	Belongs to the SEDS family
ANA_C13370	COG0489	protein tyrosine kinase activity
ANA_C13372	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANA_C13374	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANA_C13384	COG1131	(ABC) transporter
ANA_C13389	COG0788	formyltetrahydrofolate deformylase activity
ANA_C13393	COG0477	Major facilitator Superfamily
ANA_C13394	COG0463	Glycosyl transferase, family 2
ANA_C13395	COG0791	NLP P60 protein
ANA_C13404	COG4115	mRNA cleavage
ANA_C13407	COG3266	domain, Protein
ANA_C13407	COG0515	serine threonine protein kinase
ANA_C13412	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ANA_C13414	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANA_C13417	COG1104	cysteine desulfurase activity
ANA_C13418	COG2906	2 iron, 2 sulfur cluster binding
ANA_C13418	COG0822	iron-sulfur transferase activity
ANA_C13418	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ANA_C13450	COG1324	tolerance protein
ANA_C13459	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C13459	COG0515	serine threonine protein kinase
ANA_C13466	COG0631	protein serine/threonine phosphatase activity
ANA_C13483	COG2319	Wd-40 repeat
ANA_C13483	COG3903	Transcriptional regulator
ANA_C13495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_C13510	COG0582	viral genome integration into host DNA
ANA_C13512	COG2319	Wd-40 repeat
ANA_C13512	COG3903	Transcriptional regulator
ANA_C13520	COG3903	Transcriptional regulator
ANA_C13520	COG2319	Wd-40 repeat
ANA_C13529	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_C13530	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C13532	COG0582	viral genome integration into host DNA
ANA_C13533	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_C13534	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_C13535	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_C13538	COG5420	small protein containing a coiled-coil domain
ANA_C13550	COG4636	protein conserved in cyanobacteria
ANA_C13551	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANA_C13556	COG0515	serine threonine protein kinase
ANA_C13556	COG2815	serine threonine protein kinase
ANA_C13557	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ANA_C13559	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ANA_C13560	COG0170	dolichyl monophosphate biosynthetic process
ANA_C13572	COG0528	UMP kinase activity
ANA_C13573	COG0233	cytoplasmic translational termination
ANA_C13591	COG1702	phosphate starvation-inducible protein PhoH
ANA_C13593	COG0228	four-way junction DNA binding
ANA_C13606	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ANA_C13607	COG0612	Peptidase, M16
ANA_C13611	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ANA_C13619	COG0515	serine threonine protein kinase
ANA_C13622	COG0439	Biotin carboxylase
ANA_C13626	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ANA_C13633	COG3064	Membrane
ANA_C13633	COG4991	sh3 domain protein
ANA_C13633	COG0515	serine threonine protein kinase
ANA_C13634	COG0037	tRNA processing
ANA_C13640	COG0643	Histidine kinase
ANA_C13640	COG0643	Histidine kinase
ANA_C13640	COG2198	Histidine kinase
ANA_C13640	COG2198	Histidine kinase
ANA_C13643	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANA_C13644	COG0745	RESPONSE REGULATOR receiver
ANA_C13646	COG1007	ATP synthesis coupled electron transport
ANA_C13660	COG1754	DNA topoisomerase type I activity
ANA_C13660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANA_C13662	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ANA_C13664	COG1480	7TM receptor with intracellular HD hydrolase
ANA_C13674	COG0307	riboflavin synthase, alpha
ANA_C13675	COG0741	lytic transglycosylase activity
ANA_C13675	COG0739	heme binding
ANA_C13675	COG1196	nuclear chromosome segregation
ANA_C13676	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ANA_C13676	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ANA_C13684	COG0519	Catalyzes the synthesis of GMP from XMP
ANA_C13684	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANA_C13685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANA_C13686	COG0189	ligase activity
ANA_C13687	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ANA_C13704	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_C13705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_C13708	COG0251	oxidation-reduction process
ANA_C13710	COG2816	NAD+ diphosphatase activity
ANA_C13711	COG1640	4-alpha-glucanotransferase
ANA_C13712	COG1426	Protein conserved in bacteria
ANA_C13713	COG1187	pseudouridine synthase activity
ANA_C13715	COG0575	Belongs to the CDS family
ANA_C13717	COG0515	serine threonine protein kinase
ANA_C13717	COG3266	domain, Protein
ANA_C13722	COG2066	Belongs to the glutaminase family
ANA_C13724	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ANA_C13729	COG0515	serine threonine protein kinase
ANA_C13733	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ANA_C13734	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ANA_C13736	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ANA_C13739	COG0572	uridine kinase
ANA_C13742	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANA_C13743	COG2205	protein histidine kinase activity
ANA_C13746	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ANA_C13753	COG0602	queuosine metabolic process
ANA_C13754	COG0720	synthase
ANA_C13761	COG4783	chaperone-mediated protein folding
ANA_C13762	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANA_C13765	COG0617	tRNA 3'-terminal CCA addition
ANA_C13767	COG1214	PFAM Peptidase M22, glycoprotease
ANA_C13770	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANA_C13770	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANA_C13770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANA_C13770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANA_C13773	COG0583	DNA-binding transcription factor activity
ANA_C13774	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANA_C13775	COG0243	molybdopterin cofactor binding
ANA_C13776	COG2223	nitrite transmembrane transporter activity
ANA_C13782	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ANA_C13783	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ANA_C13787	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ANA_C13792	COG0157	Belongs to the NadC ModD family
ANA_C13793	COG0436	Aminotransferase
ANA_C13794	COG3118	belongs to the thioredoxin family
ANA_C13799	COG1842	Phage shock protein A
ANA_C13800	COG1842	Phage shock protein A
ANA_C13804	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ANA_C13806	COG3266	domain, Protein
ANA_C13806	COG0515	serine threonine protein kinase
ANA_C13809	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C13810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C13812	COG4636	protein conserved in cyanobacteria
ANA_C13813	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ANA_C13814	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANA_C13815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_C13816	COG2048	Heterodisulfide reductase, subunit B
ANA_C13817	COG0242	peptide deformylase activity
ANA_C13818	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C20001	COG0268	Binds directly to 16S ribosomal RNA
ANA_C20002	COG0084	hydrolase, TatD family'
ANA_C20004	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ANA_C20005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ANA_C20007	COG2022	thiamine diphosphate biosynthetic process
ANA_C20007	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANA_C20011	COG1741	Belongs to the pirin family
ANA_C20012	COG0804	urea catabolic process
ANA_C20013	COG0832	Belongs to the urease beta subunit family
ANA_C20014	COG0831	urea catabolic process
ANA_C20015	COG0829	nickel cation binding
ANA_C20016	COG1192	Involved in chromosome partitioning
ANA_C20018	COG0745	RESPONSE REGULATOR receiver
ANA_C20020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ANA_C20023	COG1192	Involved in chromosome partitioning
ANA_C20025	COG0017	Asparaginyl-tRNA synthetase
ANA_C20029	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ANA_C20031	COG0512	Glutamine amidotransferase of anthranilate synthase
ANA_C20031	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ANA_C20032	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ANA_C20035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ANA_C20041	COG1943	Transposase
ANA_C20042	COG2267	carboxylic ester hydrolase activity
ANA_C20047	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ANA_C20048	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ANA_C20048	COG0140	phosphoribosyl-ATP diphosphatase activity
ANA_C20050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ANA_C20058	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ANA_C20063	COG1049	propionate catabolic process, 2-methylcitrate cycle
ANA_C20073	COG2211	Major facilitator Superfamily
ANA_C20078	COG4956	integral membrane protein (PIN domain superfamily)
ANA_C20079	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANA_C20087	COG0436	Aminotransferase
ANA_C20088	COG0371	Dehydrogenase
ANA_C20091	COG1696	Membrane protein involved in D-alanine export
ANA_C20095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_C20097	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ANA_C20098	COG0859	PFAM glycosyl transferase family 9
ANA_C20101	COG2197	response regulator
ANA_C20104	COG0776	regulation of translation
ANA_C20106	COG2304	oxidoreductase activity
ANA_C20107	COG2304	oxidoreductase activity
ANA_C20113	COG0740	serine-type endopeptidase activity
ANA_C20115	COG0484	heat shock protein binding
ANA_C20126	COG0175	sulfate reduction
ANA_C20132	COG2205	protein histidine kinase activity
ANA_C20132	COG0784	Response regulator, receiver
ANA_C20132	COG5002	protein histidine kinase activity
ANA_C20137	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANA_C20139	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_C20140	COG1285	pathogenesis
ANA_C20141	COG0574	Belongs to the PEP-utilizing enzyme family
ANA_C20141	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANA_C20143	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ANA_C20145	COG0163	prenyltransferase activity
ANA_C20146	COG0557	exoribonuclease II activity
ANA_C20150	COG0672	)-iron permease
ANA_C20154	COG2340	Cysteine-rich secretory protein family
ANA_C20155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ANA_C20156	COG0805	protein transport
ANA_C20159	COG2319	Wd-40 repeat
ANA_C20159	COG1672	PFAM Archaeal ATPase
ANA_C20163	COG5433	transposase activity
ANA_C20165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ANA_C20166	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ANA_C20171	COG0542	response to heat
ANA_C20183	COG0539	negative regulation of cytoplasmic translation
ANA_C20187	COG2310	stress, protein
ANA_C20188	COG2310	stress, protein
ANA_C20192	COG3842	ATPase activity
ANA_C20193	COG0438	transferase activity, transferring glycosyl groups
ANA_C20194	COG0438	transferase activity, transferring glycosyl groups
ANA_C20199	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
ANA_C20201	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ANA_C20203	COG3239	Fatty acid desaturase
ANA_C20210	COG0475	glutathione-regulated potassium exporter activity
ANA_C20212	COG0488	(ABC) transporter
ANA_C20213	COG2205	protein histidine kinase activity
ANA_C20213	COG0784	Response regulator, receiver
ANA_C20214	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANA_C20217	COG2267	carboxylic ester hydrolase activity
ANA_C20218	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ANA_C20223	COG0284	orotidine-5'-phosphate decarboxylase activity
ANA_C20229	COG0484	heat shock protein binding
ANA_C20232	COG0681	Belongs to the peptidase S26 family
ANA_C20234	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ANA_C20236	COG1652	LysM domain
ANA_C20238	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANA_C20239	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ANA_C20242	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ANA_C20249	COG0651	ATP synthesis coupled electron transport
ANA_C20251	COG1982	Orn Lys Arg decarboxylase major
ANA_C20256	COG0012	GTP binding
ANA_C20261	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ANA_C20271	COG0071	Belongs to the small heat shock protein (HSP20) family
ANA_C20275	COG4585	Histidine kinase
ANA_C20276	COG2197	response regulator
ANA_C20277	COG0358	DNA primase activity
ANA_C20278	COG0440	acetolactate synthase activity
ANA_C20281	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ANA_C20287	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANA_C20287	COG0237	dephospho-CoA kinase activity
ANA_C20289	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ANA_C20290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ANA_C20291	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANA_C20294	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANA_C20295	COG0356	it plays a direct role in the translocation of protons across the membrane
ANA_C20297	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_C20298	COG1401	restriction endodeoxyribonuclease activity
ANA_C20301	COG0765	amino acid transport
ANA_C20302	COG1472	Belongs to the glycosyl hydrolase 3 family
ANA_C20303	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ANA_C20304	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ANA_C20304	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ANA_C20305	COG1562	ergosterol biosynthetic process
ANA_C20306	COG0354	folic acid binding
ANA_C20318	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANA_C20320	COG0483	inositol monophosphate 1-phosphatase activity
ANA_C20323	COG0271	Belongs to the BolA IbaG family
ANA_C20324	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ANA_C20328	COG0745	RESPONSE REGULATOR receiver
ANA_C20329	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ANA_C20332	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANA_C20333	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANA_C20336	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ANA_C20343	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_C20346	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ANA_C20356	COG0514	ATP-dependent DNA helicase (RecQ)
ANA_C20358	COG1022	Amp-dependent synthetase and ligase
ANA_C20360	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANA_C20361	COG3118	belongs to the thioredoxin family
ANA_C20362	COG1028	Short-chain dehydrogenase reductase Sdr
ANA_C20363	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_C20366	COG0443	Heat shock 70 kDa protein
ANA_C20367	COG0484	heat shock protein binding
ANA_C20371	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ANA_C20372	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ANA_C20373	COG0019	diaminopimelate decarboxylase activity
ANA_C20379	COG0793	Belongs to the peptidase S41A family
ANA_C20388	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANA_C20389	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ANA_C20390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ANA_C20391	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ANA_C20392	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ANA_C20393	COG1410	methionine synthase
ANA_C20393	COG0646	methionine synthase
ANA_C20394	COG0515	serine threonine protein kinase
ANA_C20394	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C20406	COG2010	Cytochrome c
ANA_C20407	COG0456	acetyltransferase
ANA_C20409	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_C20410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ANA_C20411	COG0457	Tetratricopeptide repeat
ANA_C20412	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANA_C20413	COG0443	Heat shock 70 kDa protein
ANA_C20415	COG1187	pseudouridine synthase activity
ANA_C20417	COG0515	serine threonine protein kinase
ANA_C20425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANA_C20426	COG3237	CsbD-like
ANA_C20429	COG3237	CsbD-like
ANA_C20430	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ANA_C20432	COG1132	(ABC) transporter
ANA_C20435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANA_C20436	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ANA_C20436	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ANA_C20442	COG2119	membrane
ANA_C20444	COG3239	Fatty acid desaturase
ANA_C20447	COG5001	Diguanylate cyclase
ANA_C20447	COG3706	GGDEF domain
ANA_C20447	COG2203	Gaf domain
ANA_C20447	COG4251	negative regulation of phosphorylation
ANA_C20451	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ANA_C20453	COG0779	Required for maturation of 30S ribosomal subunits
ANA_C20454	COG0195	Participates in both transcription termination and antitermination
ANA_C20457	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ANA_C20457	COG3266	domain, Protein
ANA_C20467	COG0481	GTPase activity
ANA_C20480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANA_C20482	COG0724	RNA recognition motif
ANA_C20483	COG0724	RNA recognition motif
ANA_C20484	COG1672	PFAM Archaeal ATPase
ANA_C20485	COG0571	ribonuclease III activity
ANA_C20491	COG4953	penicillin-binding protein 1C
ANA_C20492	COG2373	Large extracellular alpha-helical protein
ANA_C20494	COG1253	flavin adenine dinucleotide binding
ANA_C20495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ANA_C20500	COG0686	Belongs to the AlaDH PNT family
ANA_C20501	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ANA_C20502	COG1127	ABC transporter
ANA_C20505	COG0542	response to heat
ANA_C20516	COG0557	exoribonuclease II activity
ANA_C20523	COG3854	ATPases associated with a variety of cellular activities
ANA_C20525	COG0443	Heat shock 70 kDa protein
ANA_C20527	COG1597	lipid kinase activity
ANA_C20528	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ANA_C20529	COG1116	anion transmembrane transporter activity
ANA_C20530	COG1116	anion transmembrane transporter activity
ANA_C20530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ANA_C20531	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ANA_C20532	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ANA_C20533	COG0395	ABC-type sugar transport system, permease component
ANA_C20537	COG0574	Belongs to the PEP-utilizing enzyme family
ANA_C20537	COG3848	Pyruvate phosphate dikinase
ANA_C20545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ANA_C20552	COG0022	dehydrogenase e1 component
ANA_C20552	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANA_C20553	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANA_C20554	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANA_C20556	COG0454	-acetyltransferase
ANA_C20557	COG5002	protein histidine kinase activity
ANA_C20562	COG1895	HEPN domain
ANA_C20565	COG0515	serine threonine protein kinase
ANA_C20565	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_C20566	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ANA_C20569	COG0598	Magnesium transport protein CorA
ANA_C20573	COG5002	protein histidine kinase activity
ANA_C20578	COG1487	ribonuclease activity
ANA_C20583	COG4245	von Willebrand factor, type A
ANA_C20584	COG3000	fatty acid hydroxylase
ANA_C20584	COG0300	oxidoreductase activity
ANA_C20587	COG1132	(ABC) transporter
ANA_C20589	COG0488	(ABC) transporter
ANA_C20594	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ANA_C20595	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ANA_C20596	COG1304	FMN binding
ANA_C20597	COG0616	signal peptide processing
ANA_C20598	COG0415	Belongs to the DNA photolyase family
ANA_C20599	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ANA_C20601	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ANA_C20608	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ANA_C20609	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANA_C20612	COG0363	glucosamine-6-phosphate deaminase activity
ANA_C20613	COG1716	ATPase activity
ANA_C20621	COG0515	serine threonine protein kinase
ANA_C20621	COG3266	domain, Protein
ANA_C20622	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ANA_C20623	COG3852	Histidine kinase
ANA_C20625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_C20634	COG0006	proline dipeptidase activity
ANA_C20635	COG0275	rRNA processing
ANA_C20637	COG0649	NAD binding
ANA_C20639	COG0351	phosphomethylpyrimidine kinase
ANA_C20640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ANA_C20643	COG0511	ligase activity, forming carbon-carbon bonds
ANA_C20644	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ANA_C20645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANA_C20647	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ANA_C20655	COG0402	S-adenosylhomocysteine deaminase activity
ANA_C20656	COG1845	cytochrome c oxidase, subunit III
ANA_C20657	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANA_C20658	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANA_C20661	COG0778	Nitroreductase
ANA_C20662	COG3118	belongs to the thioredoxin family
ANA_C20664	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_C20666	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ANA_C20667	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ANA_C20671	COG0792	nuclease activity
ANA_C20673	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ANA_C20674	COG0569	domain protein
ANA_C20680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ANA_C20681	COG2226	methyltransferase
ANA_C20682	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANA_C20685	COG0501	Belongs to the peptidase M48B family
ANA_C20692	COG1895	HEPN domain
ANA_C20693	COG0300	oxidoreductase activity
ANA_C20694	COG4636	protein conserved in cyanobacteria
ANA_C20698	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANA_C20704	COG0587	DNA-directed DNA polymerase activity
ANA_C20709	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ANA_C20711	COG5002	protein histidine kinase activity
ANA_C20715	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_C20716	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_C20723	COG0714	Associated with various cellular activities
ANA_C20726	COG0196	riboflavin kinase activity
ANA_C20728	COG1122	ATPase activity
ANA_C20737	COG0577	efflux transmembrane transporter activity
ANA_C20737	COG1136	(ABC) transporter
ANA_C20742	COG0424	maF-like protein
ANA_C20744	COG0482	sulfurtransferase activity
ANA_C20745	COG2226	methyltransferase
ANA_C20747	COG0515	serine threonine protein kinase
ANA_C20747	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_C20749	COG2226	methyltransferase
ANA_C20750	COG2119	membrane
ANA_P10018	COG1475	DNA binding
ANA_P10019	COG1192	Involved in chromosome partitioning
ANA_P10021	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ANA_P10088	COG0443	Heat shock 70 kDa protein
ANA_P20003	COG4974	Belongs to the 'phage' integrase family
ANA_P20015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_P20017	COG5433	transposase activity
ANA_P20038	COG5433	transposase activity
ANA_P20039	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ANA_P20040	COG1518	maintenance of DNA repeat elements
ANA_P20049	COG4804	nuclease activity
ANA_P30012	COG0210	DNA helicase
ANA_P30013	COG0582	viral genome integration into host DNA