locus-tag	class	description
AA650_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA650_00025	COG0515	serine threonine protein kinase
AA650_00035	COG1187	pseudouridine synthase activity
AA650_00045	COG0443	Heat shock 70 kDa protein
AA650_00080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA650_00080	COG0237	dephospho-CoA kinase activity
AA650_00095	COG0489	protein tyrosine kinase activity
AA650_00100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA650_00120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA650_00145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA650_00165	COG0367	asparagine synthase
AA650_00200	COG0440	acetolactate synthase activity
AA650_00215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA650_00265	COG2022	thiamine diphosphate biosynthetic process
AA650_00265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_00275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA650_00330	COG0402	S-adenosylhomocysteine deaminase activity
AA650_00360	COG0598	Magnesium transport protein CorA
AA650_00365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA650_00375	COG1132	(ABC) transporter
AA650_00380	COG0328	RNA-DNA hybrid ribonuclease activity
AA650_00395	COG3385	transposase activity
AA650_00415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA650_00420	COG1252	NADH dehydrogenase
AA650_00465	COG4251	negative regulation of phosphorylation
AA650_00470	COG0784	Response regulator, receiver
AA650_00480	COG1032	radical SAM domain protein
AA650_00490	COG1505	serine-type exopeptidase activity
AA650_00500	COG1051	belongs to the nudix hydrolase family
AA650_00505	COG0628	permease
AA650_00510	COG1979	alcohol dehydrogenase
AA650_00525	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA650_00530	COG5322	oxidoreductase activity
AA650_00535	COG0825	malonyl-CoA metabolic process
AA650_00540	COG0300	oxidoreductase activity
AA650_00545	COG0302	gtp cyclohydrolase
AA650_00560	COG1994	Peptidase M50
AA650_00560	COG0517	IMP dehydrogenase activity
AA650_00570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA650_00575	COG5398	heme oxygenase
AA650_00580	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA650_00590	COG1121	(ABC) transporter
AA650_00595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA650_00620	COG1160	GTP binding
AA650_00625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA650_00665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AA650_00685	COG1752	Esterase of the alpha-beta hydrolase superfamily
AA650_00690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA650_00710	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA650_00720	COG0411	ABC transporter
AA650_00725	COG0410	ABC transporter
AA650_00750	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AA650_00770	COG0515	serine threonine protein kinase
AA650_00780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_00825	COG1372	Participates in initiation and elongation during chromosome replication
AA650_00825	COG0305	Participates in initiation and elongation during chromosome replication
AA650_00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_00875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA650_00895	COG3631	Ketosteroid isomerase-related protein
AA650_00900	COG0515	serine threonine protein kinase
AA650_00920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA650_00925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_00935	COG0175	sulfate reduction
AA650_00960	COG5002	protein histidine kinase activity
AA650_00960	COG2205	protein histidine kinase activity
AA650_00960	COG0784	Response regulator, receiver
AA650_00990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA650_01000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_01025	COG1285	pathogenesis
AA650_01030	COG0574	Belongs to the PEP-utilizing enzyme family
AA650_01030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA650_01040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA650_01055	COG0163	prenyltransferase activity
AA650_01060	COG0557	exoribonuclease II activity
AA650_01075	COG0672	)-iron permease
AA650_01095	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_01105	COG2814	Major facilitator Superfamily
AA650_01110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA650_01115	COG2132	Multicopper oxidase
AA650_01165	COG0310	cobalt ion transport
AA650_01175	COG1122	ATPase activity
AA650_01190	COG0514	ATP-dependent DNA helicase (RecQ)
AA650_01195	COG1446	asparaginase
AA650_01205	COG0167	dihydroorotate dehydrogenase activity
AA650_01220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA650_01220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA650_01245	COG0745	RESPONSE REGULATOR receiver
AA650_01250	COG5002	protein histidine kinase activity
AA650_01255	COG0704	Plays a role in the regulation of phosphate uptake
AA650_01260	COG3659	wide pore channel activity
AA650_01290	COG1214	PFAM Peptidase M22, glycoprotease
AA650_01300	COG0617	tRNA 3'-terminal CCA addition
AA650_01310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA650_01315	COG4783	chaperone-mediated protein folding
AA650_01355	COG0666	response to abiotic stimulus
AA650_01360	COG0720	synthase
AA650_01365	COG0602	queuosine metabolic process
AA650_01375	COG0215	cysteine-tRNA ligase activity
AA650_01385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA650_01390	COG0406	alpha-ribazole phosphatase activity
AA650_01395	COG0768	penicillin binding
AA650_01405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AA650_01410	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA650_01415	COG0515	serine threonine protein kinase
AA650_01415	COG3266	domain, Protein
AA650_01465	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_01465	COG0515	serine threonine protein kinase
AA650_01480	COG1012	belongs to the aldehyde dehydrogenase family
AA650_01500	COG1597	lipid kinase activity
AA650_01510	COG0443	Heat shock 70 kDa protein
AA650_01525	COG0316	Belongs to the HesB IscA family
AA650_01540	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA650_01555	COG0438	transferase activity, transferring glycosyl groups
AA650_01570	COG0167	dihydroorotate dehydrogenase activity
AA650_01575	COG0205	6-phosphofructokinase activity
AA650_01620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA650_01625	COG1136	(ABC) transporter
AA650_01625	COG0577	efflux transmembrane transporter activity
AA650_01680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA650_01690	COG0483	inositol monophosphate 1-phosphatase activity
AA650_01700	COG3659	wide pore channel activity
AA650_01705	COG1959	2 iron, 2 sulfur cluster binding
AA650_01710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_01720	COG0484	heat shock protein binding
AA650_01755	COG0557	exoribonuclease II activity
AA650_01800	COG0242	peptide deformylase activity
AA650_01820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA650_01820	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AA650_01825	COG0314	molybdopterin synthase activity
AA650_01830	COG0697	spore germination
AA650_01835	COG1619	proteins homologs of microcin C7 resistance protein MccF
AA650_01845	COG1819	glycosyl
AA650_01850	COG1215	transferase activity, transferring glycosyl groups
AA650_01855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA650_01860	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA650_01870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA650_01880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA650_01895	COG0443	Heat shock 70 kDa protein
AA650_01900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA650_01905	COG3977	Valine--pyruvate aminotransferase
AA650_01910	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA650_01920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA650_01925	COG4956	integral membrane protein (PIN domain superfamily)
AA650_01955	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AA650_01970	COG2211	Major facilitator Superfamily
AA650_01975	COG0018	arginyl-trna synthetase
AA650_01985	COG2361	Protein of unknown function DUF86
AA650_02010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA650_02015	COG0248	Ppx GppA phosphatase
AA650_02045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA650_02050	COG1294	oxidase, subunit
AA650_02055	COG1271	oxidase subunit
AA650_02095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA650_02100	COG1120	ATPase activity
AA650_02105	COG4221	oxidoreductase activity
AA650_02115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA650_02125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA650_02130	COG0552	protein localization to endoplasmic reticulum
AA650_02175	COG0604	alcohol dehydrogenase
AA650_02175	COG3321	synthase
AA650_02180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_02180	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_02180	COG3321	synthase
AA650_02180	COG4221	oxidoreductase activity
AA650_02195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA650_02195	COG2070	2-Nitropropane dioxygenase
AA650_02200	COG3320	Male sterility
AA650_02200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_02205	COG0300	oxidoreductase activity
AA650_02215	COG0644	oxidoreductase
AA650_02230	COG3385	transposase activity
AA650_02255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA650_02260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA650_02270	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AA650_02300	COG0484	heat shock protein binding
AA650_02305	COG0443	Heat shock 70 kDa protein
AA650_02310	COG2234	aminopeptidase activity
AA650_02330	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_02340	COG3118	belongs to the thioredoxin family
AA650_02345	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA650_02365	COG1022	Amp-dependent synthetase and ligase
AA650_02375	COG0514	ATP-dependent DNA helicase (RecQ)
AA650_02445	COG0791	NLP P60 protein
AA650_02455	COG0463	Glycosyl transferase, family 2
AA650_02500	COG3153	acetyltransferase
AA650_02505	COG0788	formyltetrahydrofolate deformylase activity
AA650_02515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA650_02535	COG1131	(ABC) transporter
AA650_02545	COG0006	proline dipeptidase activity
AA650_02560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA650_02595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA650_02610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA650_02625	COG2267	carboxylic ester hydrolase activity
AA650_02645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA650_02660	COG5002	protein histidine kinase activity
AA650_02670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA650_02675	COG2201	protein-glutamate methylesterase activity
AA650_02695	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_02695	COG0515	serine threonine protein kinase
AA650_02700	COG4636	protein conserved in cyanobacteria
AA650_02710	COG0335	large ribosomal subunit rRNA binding
AA650_02720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AA650_02725	COG0250	Participates in transcription elongation, termination and antitermination
AA650_02735	COG0081	regulation of translation
AA650_02740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA650_02745	COG0222	ribosome binding
AA650_02750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA650_02750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA650_02775	COG2239	Acts as a magnesium transporter
AA650_02780	COG0728	peptidoglycan biosynthetic process
AA650_02790	COG1316	TRANSCRIPTIONal
AA650_02810	COG0539	negative regulation of cytoplasmic translation
AA650_02815	COG0412	Dienelactone hydrolase
AA650_02820	COG2188	Transcriptional regulator
AA650_02885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA650_02895	COG0460	homoserine dehydrogenase
AA650_02905	COG0572	uridine kinase
AA650_02935	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_02945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA650_02970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA650_03015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA650_03040	COG3118	belongs to the thioredoxin family
AA650_03045	COG0516	GMP reductase activity
AA650_03065	COG5635	Nacht domain
AA650_03065	COG2319	Wd-40 repeat
AA650_03075	COG0628	permease
AA650_03080	COG0492	ferredoxin-NADP+ reductase activity
AA650_03085	COG0233	cytoplasmic translational termination
AA650_03090	COG0528	UMP kinase activity
AA650_03130	COG0170	dolichyl monophosphate biosynthetic process
AA650_03150	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AA650_03160	COG2815	serine threonine protein kinase
AA650_03160	COG0515	serine threonine protein kinase
AA650_03165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA650_03170	COG0745	RESPONSE REGULATOR receiver
AA650_03180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA650_03205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA650_03210	COG0271	Belongs to the BolA IbaG family
AA650_03230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA650_03245	COG2166	iron-sulfur cluster assembly
AA650_03270	COG4232	protein-disulfide reductase activity
AA650_03275	COG1333	cytochrome c biogenesis protein
AA650_03280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA650_03285	COG0745	RESPONSE REGULATOR receiver
AA650_03290	COG0432	Pfam Uncharacterised protein family UPF0047
AA650_03300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA650_03305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA650_03340	COG3657	addiction module killer protein
AA650_03390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA650_03395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_03415	COG0811	peptide transport
AA650_03420	COG0848	biopolymer transport protein
AA650_03425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA650_03435	COG2081	HI0933 family
AA650_03465	COG4636	protein conserved in cyanobacteria
AA650_03470	COG0542	response to heat
AA650_03490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA650_03500	COG3794	PFAM blue (type 1) copper domain protein
AA650_03510	COG0066	3-isopropylmalate dehydratase activity
AA650_03525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA650_03545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA650_03555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA650_03560	COG1799	cell septum assembly
AA650_03565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AA650_03615	COG1468	defense response to virus
AA650_03615	COG1518	maintenance of DNA repeat elements
AA650_03630	COG3320	Male sterility
AA650_03630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_03640	COG2070	2-Nitropropane dioxygenase
AA650_03640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA650_03645	COG3321	synthase
AA650_03650	COG3321	synthase
AA650_03650	COG0604	alcohol dehydrogenase
AA650_03670	COG1136	(ABC) transporter
AA650_03675	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_03680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_03695	COG0616	signal peptide processing
AA650_03700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA650_03730	COG2226	methyltransferase
AA650_03735	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA650_03745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA650_03760	COG0772	Belongs to the SEDS family
AA650_03765	COG0489	protein tyrosine kinase activity
AA650_03780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_03795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA650_03795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA650_03815	COG3385	transposase activity
AA650_03825	COG0484	heat shock protein binding
AA650_03830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA650_03835	COG1045	serine acetyltransferase
AA650_03870	COG0483	inositol monophosphate 1-phosphatase activity
AA650_03890	COG0363	glucosamine-6-phosphate deaminase activity
AA650_03895	COG1716	ATPase activity
AA650_03930	COG1222	aaa ATPase
AA650_03935	COG1049	propionate catabolic process, 2-methylcitrate cycle
AA650_04030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA650_04085	COG1472	Belongs to the glycosyl hydrolase 3 family
AA650_04090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA650_04095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA650_04095	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA650_04100	COG1562	ergosterol biosynthetic process
AA650_04115	COG0071	Belongs to the small heat shock protein (HSP20) family
AA650_04165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AA650_04195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA650_04230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_04235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA650_04245	COG0321	lipoyl(octanoyl) transferase activity
AA650_04250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA650_04255	COG0501	Belongs to the peptidase M48B family
AA650_04265	COG0489	protein tyrosine kinase activity
AA650_04275	COG0110	maltose O-acetyltransferase activity
AA650_04285	COG0463	Glycosyl transferase, family 2
AA650_04290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_04315	COG0438	transferase activity, transferring glycosyl groups
AA650_04350	COG2089	acid synthase
AA650_04375	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AA650_04385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA650_04390	COG1132	(ABC) transporter
AA650_04395	COG1086	Polysaccharide biosynthesis protein
AA650_04425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_04435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AA650_04490	COG0312	modulator of DNA gyrase
AA650_04500	COG1573	uracil-dna glycosylase
AA650_04515	COG1058	Belongs to the CinA family
AA650_04515	COG1546	Belongs to the CinA family
AA650_04525	COG1032	radical SAM domain protein
AA650_04540	COG0180	Tryptophanyl-tRNA synthetase
AA650_04580	COG0124	histidyl-tRNA synthetase
AA650_04605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA650_04610	COG0573	inorganic phosphate transmembrane transporter activity
AA650_04615	COG0581	inorganic phosphate transmembrane transporter activity
AA650_04620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA650_04665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AA650_04675	COG4636	protein conserved in cyanobacteria
AA650_04690	COG0724	RNA recognition motif
AA650_04710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_04740	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_04740	COG0515	serine threonine protein kinase
AA650_04760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AA650_04765	COG0512	Glutamine amidotransferase of anthranilate synthase
AA650_04770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA650_04780	COG0004	ammonium transporteR
AA650_04790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA650_04805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA650_04815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA650_04820	COG0415	Belongs to the DNA photolyase family
AA650_04825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA650_04830	COG3383	formate dehydrogenase (NAD+) activity
AA650_04900	COG3385	transposase activity
AA650_04985	COG0739	heme binding
AA650_04990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AA650_04995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AA650_05005	COG0713	ATP synthesis coupled electron transport
AA650_05010	COG0839	Belongs to the complex I subunit 6 family
AA650_05020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA650_05025	COG0372	Belongs to the citrate synthase family
AA650_05030	COG2062	phosphohistidine phosphatase, SixA
AA650_05050	COG1131	(ABC) transporter
AA650_05060	COG2203	Gaf domain
AA650_05060	COG0840	transmembrane signaling receptor activity
AA650_05065	COG2198	Histidine kinase
AA650_05065	COG0643	Histidine kinase
AA650_05075	COG0596	Alpha beta hydrolase
AA650_05080	COG3639	organic phosphonate transmembrane transporter activity
AA650_05090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA650_05115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA650_05120	COG0509	glycine decarboxylation via glycine cleavage system
AA650_05130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA650_05135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA650_05170	COG4279	zinc finger
AA650_05185	COG0393	Putative heavy-metal-binding
AA650_05200	COG0659	secondary active sulfate transmembrane transporter activity
AA650_05220	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_05270	COG0719	Fe-S assembly protein
AA650_05275	COG0396	ATPase activity
AA650_05280	COG0719	Fe-S assembly protein
AA650_05285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA650_05290	COG0454	-acetyltransferase
AA650_05295	COG5002	protein histidine kinase activity
AA650_05385	COG0814	amino acid
AA650_05420	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
AA650_05445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA650_05460	COG4251	negative regulation of phosphorylation
AA650_05475	COG3429	Glucose-6-phosphate dehydrogenase subunit
AA650_05475	COG3409	Peptidoglycan-binding domain 1 protein
AA650_05480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA650_05485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AA650_05495	COG0745	RESPONSE REGULATOR receiver
AA650_05500	COG3706	GGDEF domain
AA650_05500	COG0745	RESPONSE REGULATOR receiver
AA650_05505	COG5002	protein histidine kinase activity
AA650_05505	COG0784	Response regulator, receiver
AA650_05525	COG0395	ABC-type sugar transport system, permease component
AA650_05545	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA650_05560	COG0515	serine threonine protein kinase
AA650_05575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA650_05585	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_05590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_05595	COG1492	cobalamin metabolic process
AA650_05605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_05620	COG1253	flavin adenine dinucleotide binding
AA650_05640	COG3237	CsbD-like
AA650_05655	COG3237	CsbD-like
AA650_05660	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AA650_05670	COG1132	(ABC) transporter
AA650_05685	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA650_05725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA650_05755	COG1193	negative regulation of DNA recombination
AA650_05790	COG0668	transmembrane transport
AA650_05795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AA650_05820	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AA650_05840	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA650_05855	COG0426	domain, Protein
AA650_05855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_05860	COG0426	domain, Protein
AA650_05860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_05905	COG0312	modulator of DNA gyrase
AA650_05920	COG0047	phosphoribosylformylglycinamidine synthase activity
AA650_05930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA650_05935	COG0735	belongs to the Fur family
AA650_05940	COG0330	HflC and HflK could
AA650_05965	COG2091	lysine biosynthetic process via aminoadipic acid
AA650_05970	COG0429	hydrolase of the alpha beta-hydrolase fold
AA650_05975	COG0745	RESPONSE REGULATOR receiver
AA650_05980	COG1160	GTP binding
AA650_05985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AA650_06060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_06065	COG4636	protein conserved in cyanobacteria
AA650_06080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_06120	COG0667	Aldo Keto reductase
AA650_06140	COG3385	transposase activity
AA650_06145	COG3385	transposase activity
AA650_06165	COG1473	amidohydrolase
AA650_06180	COG1872	DUF167
AA650_06195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AA650_06200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA650_06225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_06235	COG0038	chloride channel
AA650_06240	COG1136	(ABC) transporter
AA650_06260	COG0592	DNA-directed DNA polymerase activity
AA650_06270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA650_06285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA650_06300	COG0515	serine threonine protein kinase
AA650_06330	COG2198	Histidine kinase
AA650_06330	COG0784	Response regulator, receiver
AA650_06330	COG2205	protein histidine kinase activity
AA650_06330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA650_06340	COG0542	response to heat
AA650_06355	COG1127	ABC transporter
AA650_06360	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AA650_06365	COG0686	Belongs to the AlaDH PNT family
AA650_06370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA650_06385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA650_06415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA650_06415	COG3266	domain, Protein
AA650_06425	COG0195	Participates in both transcription termination and antitermination
AA650_06430	COG0779	Required for maturation of 30S ribosomal subunits
AA650_06435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AA650_06495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA650_06500	COG0051	transcription antitermination factor activity, RNA binding
AA650_06505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA650_06530	COG0316	Belongs to the HesB IscA family
AA650_06545	COG0070	glutamate synthase
AA650_06545	COG0069	glutamate synthase activity
AA650_06545	COG0067	glutamate synthase
AA650_06570	COG0726	polysaccharide deacetylase
AA650_06575	COG2076	Multidrug Resistance protein
AA650_06580	COG0463	Glycosyl transferase, family 2
AA650_06590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_06605	COG0586	Pfam SNARE associated Golgi protein
AA650_06610	COG1132	(ABC) transporter
AA650_06675	COG0254	rRNA binding
AA650_06680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA650_06690	COG0101	tRNA pseudouridine synthase activity
AA650_06695	COG0203	ribosomal protein L17
AA650_06725	COG0563	adenylate kinase activity
AA650_06730	COG0201	protein transport
AA650_06755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA650_06760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AA650_06765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA650_06770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA650_06785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA650_06790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA650_06805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA650_06810	COG0089	rRNA binding
AA650_06815	COG0088	Forms part of the polypeptide exit tunnel
AA650_06860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA650_06885	COG0617	tRNA 3'-terminal CCA addition
AA650_06890	COG4636	protein conserved in cyanobacteria
AA650_06915	COG3937	granule-associated protein
AA650_06925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_06930	COG0631	protein serine/threonine phosphatase activity
AA650_06940	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_06940	COG0515	serine threonine protein kinase
AA650_06965	COG1834	amidinotransferase
AA650_06990	COG0450	alkyl hydroperoxide reductase
AA650_06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA650_07000	COG5398	heme oxygenase
AA650_07010	COG1230	cation diffusion facilitator family transporter
AA650_07050	COG2205	protein histidine kinase activity
AA650_07060	COG1230	cation diffusion facilitator family transporter
AA650_07085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA650_07090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA650_07120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA650_07130	COG0463	Glycosyl transferase, family 2
AA650_07165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA650_07180	COG0009	L-threonylcarbamoyladenylate synthase
AA650_07185	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AA650_07195	COG0312	modulator of DNA gyrase
AA650_07200	COG0312	modulator of DNA gyrase
AA650_07205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_07220	COG2183	response to ionizing radiation
AA650_07240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AA650_07255	COG1950	PFAM Membrane protein of
AA650_07275	COG2010	Cytochrome c
AA650_07300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA650_07305	COG0784	Response regulator, receiver
AA650_07310	COG0564	pseudouridine synthase activity
AA650_07325	COG0237	dephospho-CoA kinase activity
AA650_07330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA650_07335	COG1413	lyase activity
AA650_07340	COG1413	lyase activity
AA650_07345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA650_07350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA650_07360	COG0237	dephospho-CoA kinase activity
AA650_07375	COG0121	glutamine amidotransferase
AA650_07380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA650_07385	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA650_07390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA650_07395	COG4208	sulfate ABC transporter
AA650_07405	COG1715	Restriction endonuclease
AA650_07415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA650_07425	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA650_07435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA650_07450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA650_07460	COG0515	serine threonine protein kinase
AA650_07460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_07470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AA650_07475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_07480	COG0456	acetyltransferase
AA650_07505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA650_07515	COG0416	fatty acid biosynthetic process
AA650_07520	COG0534	Mate efflux family protein
AA650_07525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA650_07530	COG0824	Thioesterase
AA650_07585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA650_07615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA650_07620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA650_07635	COG1002	Type II restriction enzyme, methylase subunits
AA650_07645	COG0629	single-stranded DNA binding
AA650_07650	COG1077	Cell shape determining protein MreB Mrl
AA650_07675	COG0475	glutathione-regulated potassium exporter activity
AA650_07680	COG2247	cell wall binding repeat
AA650_07680	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA650_07685	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA650_07690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA650_07700	COG0142	geranyltranstransferase activity
AA650_07725	COG2052	Domain of unknown function (DUF370)
AA650_07745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA650_07750	COG2267	carboxylic ester hydrolase activity
AA650_07765	COG0454	-acetyltransferase
AA650_07775	COG0824	Thioesterase
AA650_07780	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_07790	COG1575	Belongs to the MenA family. Type 1 subfamily
AA650_07800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA650_07890	COG0003	Pfam Anion-transporting ATPase
AA650_07895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_07900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA650_07920	COG1233	COG1233 Phytoene dehydrogenase and related
AA650_07930	COG3956	TIGRFAM MazG family protein
AA650_07945	COG4636	protein conserved in cyanobacteria
AA650_07975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AA650_07985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA650_07990	COG0546	phosphoglycolate phosphatase activity
AA650_07995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA650_08010	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA650_08020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA650_08025	COG2226	methyltransferase
AA650_08030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA650_08035	COG0569	domain protein
AA650_08075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA650_08080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA650_08095	COG3118	belongs to the thioredoxin family
AA650_08125	COG1487	ribonuclease activity
AA650_08185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA650_08190	COG0751	glycine-tRNA ligase activity
AA650_08195	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA650_08200	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA650_08240	COG0673	inositol 2-dehydrogenase activity
AA650_08250	COG0110	maltose O-acetyltransferase activity
AA650_08255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_08260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA650_08310	COG2886	Uncharacterised protein family (UPF0175)
AA650_08345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_08355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_08385	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AA650_08415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA650_08450	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_08455	COG3609	addiction module antidote protein, CC2985 family
AA650_08480	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA650_08515	COG2124	cytochrome p450
AA650_08545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA650_08550	COG0330	HflC and HflK could
AA650_08555	COG1596	polysaccharide export
AA650_08565	COG1131	(ABC) transporter
AA650_08570	COG0131	Imidazoleglycerol-phosphate dehydratase
AA650_08580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA650_08590	COG4372	Transposase
AA650_08630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_08635	COG1372	Participates in initiation and elongation during chromosome replication
AA650_08635	COG0187	DNA topoisomerase II activity
AA650_08645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA650_08670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA650_08685	COG0284	orotidine-5'-phosphate decarboxylase activity
AA650_08720	COG0681	Belongs to the peptidase S26 family
AA650_08730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA650_08735	COG1652	LysM domain
AA650_08750	COG2310	stress, protein
AA650_08765	COG0539	negative regulation of cytoplasmic translation
AA650_08805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA650_08810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA650_08815	COG1845	cytochrome c oxidase, subunit III
AA650_08835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA650_08840	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA650_08855	COG0438	transferase activity, transferring glycosyl groups
AA650_08895	COG1215	transferase activity, transferring glycosyl groups
AA650_08910	COG1132	(ABC) transporter
AA650_08935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_08955	COG0673	inositol 2-dehydrogenase activity
AA650_08965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA650_08970	COG0489	protein tyrosine kinase activity
AA650_08975	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AA650_09020	COG1487	ribonuclease activity
AA650_09055	COG3385	transposase activity
AA650_09070	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA650_09115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AA650_09120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AA650_09125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AA650_09145	COG0706	membrane insertase activity
AA650_09160	COG4680	protein conserved in bacteria
AA650_09185	COG1691	(AIR) carboxylase
AA650_09190	COG4166	transmembrane transport
AA650_09220	COG4242	Belongs to the peptidase S51 family
AA650_09230	COG1487	ribonuclease activity
AA650_09280	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA650_09285	COG1253	flavin adenine dinucleotide binding
AA650_09290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AA650_09325	COG0259	pyridoxamine-phosphate oxidase activity
AA650_09330	COG0628	permease
AA650_09340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA650_09345	COG1166	arginine decarboxylase activity
AA650_09350	COG0105	UTP biosynthetic process
AA650_09355	COG0861	Integral membrane protein TerC family
AA650_09365	COG0745	RESPONSE REGULATOR receiver
AA650_09380	COG0419	ATPase involved in DNA repair
AA650_09425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA650_09430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA650_09460	COG0673	inositol 2-dehydrogenase activity
AA650_09465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AA650_09480	COG2226	methyltransferase
AA650_09485	COG0306	phosphate transporter
AA650_09490	COG0697	spore germination
AA650_09505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA650_09520	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA650_09520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_09580	COG0129	dihydroxy-acid dehydratase activity
AA650_09605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA650_09605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA650_09620	COG2226	methyltransferase
AA650_09620	COG1073	alpha beta
AA650_09635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AA650_09645	COG0505	Belongs to the CarA family
AA650_09715	COG1785	Belongs to the alkaline phosphatase family
AA650_09745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA650_09765	COG1530	ribonuclease E activity
AA650_09780	COG0077	Prephenate dehydratase
AA650_09780	COG1605	Chorismate mutase
AA650_09790	COG0577	efflux transmembrane transporter activity
AA650_09790	COG1136	(ABC) transporter
AA650_09810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA650_09825	COG0395	ABC-type sugar transport system, permease component
AA650_09840	COG2304	oxidoreductase activity
AA650_09845	COG0612	Peptidase, M16
AA650_09855	COG0748	coenzyme F420 binding
AA650_09865	COG0351	phosphomethylpyrimidine kinase
AA650_09875	COG0649	NAD binding
AA650_09900	COG0275	rRNA processing
AA650_09935	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA650_09950	COG2205	protein histidine kinase activity
AA650_09955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_09975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA650_10005	COG0745	RESPONSE REGULATOR receiver
AA650_10010	COG1366	Belongs to the anti-sigma-factor antagonist family
AA650_10050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA650_10055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA650_10075	COG1160	GTP binding
AA650_10080	COG1162	GTPase activity
AA650_10095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA650_10105	COG2066	Belongs to the glutaminase family
AA650_10145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AA650_10150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_10165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA650_10165	COG0758	DNA mediated transformation
AA650_10200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA650_10235	COG0745	RESPONSE REGULATOR receiver
AA650_10270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_10290	COG2255	four-way junction helicase activity
AA650_10330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_10330	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_10330	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_10330	COG3321	synthase
AA650_10330	COG0300	oxidoreductase activity
AA650_10350	COG0484	heat shock protein binding
AA650_10365	COG0740	serine-type endopeptidase activity
AA650_10380	COG0577	efflux transmembrane transporter activity
AA650_10380	COG1136	(ABC) transporter
AA650_10430	COG1122	ATPase activity
AA650_10435	COG0357	Ribosomal RNA small subunit methyltransferase G
AA650_10440	COG0196	riboflavin kinase activity
AA650_10455	COG0714	Associated with various cellular activities
AA650_10475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA650_10480	COG1408	metallophosphoesterase
AA650_10495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_10595	COG0003	Pfam Anion-transporting ATPase
AA650_10615	COG0006	proline dipeptidase activity
AA650_10620	COG3385	transposase activity
AA650_10650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA650_10675	COG0745	RESPONSE REGULATOR receiver
AA650_10680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA650_10690	COG3903	Transcriptional regulator
AA650_10690	COG3629	intracellular signal transduction
AA650_10705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA650_10725	COG0515	serine threonine protein kinase
AA650_10725	COG2815	serine threonine protein kinase
AA650_10735	COG4948	Mandelate Racemase Muconate Lactonizing
AA650_10765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA650_10770	COG3266	domain, Protein
AA650_10770	COG0515	serine threonine protein kinase
AA650_10780	COG0575	Belongs to the CDS family
AA650_10790	COG1187	pseudouridine synthase activity
AA650_10795	COG1426	Protein conserved in bacteria
AA650_10800	COG1640	4-alpha-glucanotransferase
AA650_10810	COG0251	oxidation-reduction process
AA650_10820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA650_10820	COG1013	pyruvate-flavodoxin oxidoreductase activity
AA650_10820	COG0674	pyruvate-flavodoxin oxidoreductase activity
AA650_10820	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AA650_10825	COG0464	growth
AA650_10840	COG2197	response regulator
AA650_10865	COG0517	IMP dehydrogenase activity
AA650_10865	COG1125	glycine betaine transport
AA650_10900	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AA650_10905	COG0668	transmembrane transport
AA650_10910	COG0668	transmembrane transport
AA650_10920	COG5002	protein histidine kinase activity
AA650_10930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA650_10955	COG1587	Uroporphyrinogen-III synthase
AA650_10960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA650_10965	COG0745	RESPONSE REGULATOR receiver
AA650_10990	COG0842	Transport permease protein
AA650_10990	COG1131	(ABC) transporter
AA650_10990	COG1716	ATPase activity
AA650_11005	COG0643	Histidine kinase
AA650_11005	COG2198	Histidine kinase
AA650_11010	COG0840	transmembrane signaling receptor activity
AA650_11010	COG2203	Gaf domain
AA650_11025	COG2201	protein-glutamate methylesterase activity
AA650_11030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA650_11045	COG0531	amino acid
AA650_11075	COG1234	tRNA 3'-trailer cleavage
AA650_11080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA650_11085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA650_11095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA650_11100	COG0772	Belongs to the SEDS family
AA650_11155	COG0577	efflux transmembrane transporter activity
AA650_11155	COG1136	(ABC) transporter
AA650_11170	COG0148	phosphopyruvate hydratase activity
AA650_11175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA650_11195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA650_11195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA650_11240	COG0408	coproporphyrinogen oxidase activity
AA650_11260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA650_11265	COG3385	transposase activity
AA650_11290	COG2084	Dehydrogenase
AA650_11295	COG0629	single-stranded DNA binding
AA650_11335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_11335	COG3320	Male sterility
AA650_11345	COG3239	Fatty acid desaturase
AA650_11350	COG3239	Fatty acid desaturase
AA650_11365	COG1136	(ABC) transporter
AA650_11375	COG0564	pseudouridine synthase activity
AA650_11390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_11445	COG0481	GTPase activity
AA650_11450	COG0277	FAD linked oxidase domain protein
AA650_11455	COG0247	lactate metabolic process
AA650_11470	COG0515	serine threonine protein kinase
AA650_11470	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_11475	COG0572	uridine kinase
AA650_11480	COG2003	Belongs to the UPF0758 family
AA650_11485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AA650_11510	COG0517	IMP dehydrogenase activity
AA650_11510	COG0516	GMP reductase activity
AA650_11585	COG0438	transferase activity, transferring glycosyl groups
AA650_11600	COG2204	response regulator
AA650_11635	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
AA650_11705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_11720	COG0243	molybdopterin cofactor binding
AA650_11725	COG1116	anion transmembrane transporter activity
AA650_11730	COG1116	anion transmembrane transporter activity
AA650_11730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_11735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_11740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_11760	COG3385	transposase activity
AA650_11795	COG0523	cobalamin synthesis protein
AA650_11805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_11810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA650_11815	COG0581	inorganic phosphate transmembrane transporter activity
AA650_11820	COG0573	inorganic phosphate transmembrane transporter activity
AA650_11830	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_11840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA650_11845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA650_11850	COG3266	domain, Protein
AA650_11850	COG0515	serine threonine protein kinase
AA650_11915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA650_11930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA650_11940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_11940	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA650_11950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA650_11975	COG0783	Belongs to the Dps family
AA650_11985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA650_11990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_12000	COG0494	nUDIX hydrolase
AA650_12015	COG1126	abc transporter atp-binding protein
AA650_12020	COG0765	amino acid transport
AA650_12025	COG4597	amino acid ABC transporter
AA650_12030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA650_12035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AA650_12040	COG0590	tRNA wobble adenosine to inosine editing
AA650_12050	COG4935	Belongs to the peptidase S8 family
AA650_12050	COG1404	Belongs to the peptidase S8 family
AA650_12075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA650_12095	COG1136	(ABC) transporter
AA650_12125	COG0384	phenazine biosynthesis protein PhzF
AA650_12140	COG0612	Peptidase, M16
AA650_12145	COG0612	Peptidase, M16
AA650_12150	COG0004	ammonium transporteR
AA650_12200	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AA650_12200	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AA650_12240	COG0616	signal peptide processing
AA650_12250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AA650_12255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA650_12260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA650_12270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA650_12275	COG1192	Involved in chromosome partitioning
AA650_12280	COG1196	nuclear chromosome segregation
AA650_12280	COG1674	ftsk spoiiie
AA650_12295	COG0095	Lipoate-protein ligase
AA650_12310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_12320	COG5002	protein histidine kinase activity
AA650_12325	COG0745	RESPONSE REGULATOR receiver
AA650_12330	COG0138	bifunctional purine biosynthesis protein purh
AA650_12360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA650_12380	COG3536	Protein conserved in bacteria
AA650_12395	COG0515	serine threonine protein kinase
AA650_12395	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_12415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AA650_12425	COG0628	permease
AA650_12435	COG1316	TRANSCRIPTIONal
AA650_12450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA650_12450	COG0438	transferase activity, transferring glycosyl groups
AA650_12470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_12480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA650_12485	COG0515	serine threonine protein kinase
AA650_12485	COG3266	domain, Protein
AA650_12515	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_12515	COG0515	serine threonine protein kinase
AA650_12530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AA650_12540	COG0745	RESPONSE REGULATOR receiver
AA650_12545	COG3385	transposase activity
AA650_12560	COG1088	dTDP-glucose 4,6-dehydratase activity
AA650_12590	COG1943	Transposase
AA650_12600	COG0587	DNA-directed DNA polymerase activity
AA650_12640	COG0154	amidase activity
AA650_12645	COG1473	amidohydrolase
AA650_12650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AA650_12655	COG3266	domain, Protein
AA650_12655	COG0515	serine threonine protein kinase
AA650_12660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA650_12695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_12700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA650_12705	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AA650_12710	COG2211	Major facilitator Superfamily
AA650_12720	COG1053	succinate dehydrogenase
AA650_12760	COG0701	Predicted permease
AA650_12765	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AA650_12815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA650_12825	COG0798	PFAM Bile acid sodium symporter
AA650_12830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AA650_12840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA650_12855	COG3118	belongs to the thioredoxin family
AA650_12865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA650_12870	COG0830	nickel cation binding
AA650_12875	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AA650_12920	COG1657	PFAM Prenyltransferase squalene oxidase
AA650_12975	COG0024	Methionine aminopeptidase
AA650_12985	COG0612	Peptidase, M16
AA650_13010	COG0285	dihydrofolate synthase activity
AA650_13050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AA650_13060	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AA650_13065	COG1959	2 iron, 2 sulfur cluster binding
AA650_13105	COG1091	dTDP-4-dehydrorhamnose reductase activity
AA650_13150	COG0469	pyruvate kinase activity
AA650_13180	COG1606	tRNA processing
AA650_13185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA650_13190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA650_13195	COG0720	synthase
AA650_13230	COG0752	glycyl-tRNA synthetase alpha subunit
AA650_13240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AA650_13250	COG0406	alpha-ribazole phosphatase activity
AA650_13265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AA650_13280	COG0438	transferase activity, transferring glycosyl groups
AA650_13305	COG0513	Belongs to the DEAD box helicase family
AA650_13325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_13335	COG0303	'Molybdopterin
AA650_13340	COG3258	Cytochrome c
AA650_13385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA650_13385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA650_13420	COG2267	carboxylic ester hydrolase activity
AA650_13435	COG0538	isocitrate dehydrogenase activity
AA650_13440	COG0515	serine threonine protein kinase
AA650_13445	COG0571	ribonuclease III activity
AA650_13455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_13460	COG1116	anion transmembrane transporter activity
AA650_13460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_13465	COG1116	anion transmembrane transporter activity
AA650_13480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_13495	COG4771	TonB-dependent receptor
AA650_13500	COG0826	peptidase U32
AA650_13550	COG1940	carbohydrate kinase activity
AA650_13555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA650_13565	COG0750	zinc metalloprotease
AA650_13570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA650_13580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA650_13620	COG1982	Orn Lys Arg decarboxylase major
AA650_13650	COG3394	polysaccharide catabolic process
AA650_13720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA650_13730	COG0151	Belongs to the GarS family
AA650_13735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA650_13735	COG0475	glutathione-regulated potassium exporter activity
AA650_13765	COG0714	Associated with various cellular activities
AA650_13780	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AA650_13820	COG0457	Tetratricopeptide repeat
AA650_13825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA650_13840	COG0515	serine threonine protein kinase
AA650_13855	COG0439	Biotin carboxylase
AA650_13915	COG2197	response regulator
AA650_13925	COG1234	tRNA 3'-trailer cleavage
AA650_13930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_13945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA650_13955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA650_13975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA650_14015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_14020	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA650_14030	COG1785	Belongs to the alkaline phosphatase family
AA650_14040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AA650_14050	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_14065	COG0525	valine-tRNA ligase activity
AA650_14100	COG0534	Mate efflux family protein
AA650_14115	COG0837	glucose binding
AA650_14145	COG0322	excinuclease ABC activity
AA650_14150	COG0463	Glycosyl transferase, family 2
AA650_14150	COG0457	Tetratricopeptide repeat
AA650_14155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_14160	COG0436	Aminotransferase
AA650_14205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_14215	COG0561	phosphatase activity
AA650_14230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA650_14230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA650_14250	COG0450	alkyl hydroperoxide reductase
AA650_14265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_14300	COG0484	heat shock protein binding
AA650_14330	COG0745	RESPONSE REGULATOR receiver
AA650_14330	COG3706	GGDEF domain
AA650_14365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_14380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA650_14425	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA650_14430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA650_14435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA650_14445	COG0584	glycerophosphoryl diester phosphodiesterase
AA650_14465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA650_14475	COG3385	transposase activity
AA650_14540	COG2852	Protein conserved in bacteria
AA650_14565	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_14580	COG2161	toxin-antitoxin pair type II binding
AA650_14585	COG4115	mRNA cleavage
AA650_14595	COG4658	electron transport chain
AA650_14610	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_14620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA650_14625	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_14630	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_14635	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AA650_14640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA650_14640	COG4451	ribulose bisphosphate carboxylase, small
AA650_14655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_14665	COG0583	DNA-binding transcription factor activity
AA650_14740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA650_14760	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA650_14765	COG2217	Heavy metal translocating P-type atpase
AA650_14775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA650_14810	COG0708	Exodeoxyribonuclease III
AA650_14875	COG0475	glutathione-regulated potassium exporter activity
AA650_14880	COG0488	(ABC) transporter
AA650_14905	COG0308	aminopeptidase N
AA650_14930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA650_14990	COG3848	Pyruvate phosphate dikinase
AA650_14990	COG0574	Belongs to the PEP-utilizing enzyme family
AA650_15005	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_15030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA650_15050	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA650_15055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA650_15075	COG3118	belongs to the thioredoxin family
AA650_15080	COG0563	adenylate kinase activity
AA650_15120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA650_15130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_15200	COG0746	molybdenum cofactor guanylyltransferase activity
AA650_15210	COG2501	S4 domain
AA650_15265	COG0776	regulation of translation
AA650_15290	COG0534	Mate efflux family protein
AA650_15295	COG0494	nUDIX hydrolase
AA650_15340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AA650_15350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_15355	COG0432	Pfam Uncharacterised protein family UPF0047
AA650_15375	COG0561	phosphatase activity
AA650_15380	COG2197	response regulator
AA650_15395	COG0859	PFAM glycosyl transferase family 9
AA650_15400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA650_15415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_15430	COG2304	oxidoreductase activity
AA650_15435	COG2304	oxidoreductase activity
AA650_15470	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AA650_15475	COG0298	carbon dioxide binding
AA650_15480	COG0409	Hydrogenase expression formation protein
AA650_15505	COG2226	methyltransferase
AA650_15515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA650_15560	COG0582	viral genome integration into host DNA
AA650_15615	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA650_15620	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AA650_15630	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA650_15690	COG1518	maintenance of DNA repeat elements
AA650_15695	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AA650_15730	COG0157	Belongs to the NadC ModD family
AA650_15735	COG0436	Aminotransferase
AA650_15740	COG3118	belongs to the thioredoxin family
AA650_15755	COG1842	Phage shock protein A
AA650_15760	COG1842	Phage shock protein A
AA650_15780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AA650_15785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AA650_15800	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_15850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA650_15880	COG2217	Heavy metal translocating P-type atpase
AA650_15890	COG1090	epimerase
AA650_15900	COG0583	DNA-binding transcription factor activity
AA650_15910	COG3118	belongs to the thioredoxin family
AA650_15915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA650_15950	COG4451	ribulose bisphosphate carboxylase, small
AA650_15960	COG1850	ribulose-bisphosphate carboxylase activity
AA650_16030	COG0438	transferase activity, transferring glycosyl groups
AA650_16035	COG1177	transmembrane transport
AA650_16050	COG1160	GTP binding
AA650_16060	COG2912	Transglutaminase-like superfamily
AA650_16075	COG3385	transposase activity
AA650_16085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA650_16090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA650_16190	COG1136	(ABC) transporter
AA650_16190	COG0577	efflux transmembrane transporter activity
AA650_16195	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_16210	COG3385	transposase activity
AA650_16235	COG3311	Transcriptional regulator
AA650_16240	COG1569	PIN domain
AA650_16285	COG4644	lycopene metabolic process
AA650_16375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AA650_16410	COG1192	Involved in chromosome partitioning
AA650_16415	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA650_16455	COG1475	DNA binding
AA650_16460	COG1192	Involved in chromosome partitioning
AA650_16565	COG2192	nodulation
AA650_16595	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_16600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA650_16605	COG0459	protein refolding
AA650_16615	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AA650_16620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA650_16655	COG2885	chlorophyll binding
AA650_16655	COG3047	cAMP biosynthetic process
AA650_16665	COG0012	GTP binding
AA650_16700	COG0793	Belongs to the peptidase S41A family
AA650_16705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_16705	COG0515	serine threonine protein kinase
AA650_16715	COG0850	regulation of cytokinetic process
AA650_16720	COG2894	cell division
AA650_16730	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AA650_16750	COG0670	Belongs to the BI1 family
AA650_16765	COG3239	Fatty acid desaturase
AA650_16775	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AA650_16785	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
AA650_16825	COG2119	membrane
AA650_16845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA650_16845	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AA650_16855	COG2373	Large extracellular alpha-helical protein
AA650_16860	COG4953	penicillin-binding protein 1C
AA650_16885	COG0571	ribonuclease III activity
AA650_16890	COG1672	PFAM Archaeal ATPase
AA650_16895	COG0724	RNA recognition motif
AA650_16900	COG0724	RNA recognition motif
AA650_16915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA650_16925	COG1543	Belongs to the glycosyl hydrolase 57 family
AA650_16950	COG0443	Heat shock 70 kDa protein
AA650_16970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA650_17005	COG3854	ATPases associated with a variety of cellular activities
AA650_17030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_17045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA650_17050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_17065	COG0802	atpase or kinase
AA650_17075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AA650_17080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA650_17110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA650_17160	COG1566	PFAM secretion protein HlyD family protein
AA650_17170	COG1136	(ABC) transporter
AA650_17170	COG0577	efflux transmembrane transporter activity
AA650_17190	COG2385	sporulation resulting in formation of a cellular spore
AA650_17195	COG0489	protein tyrosine kinase activity
AA650_17210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA650_17225	COG1252	NADH dehydrogenase
AA650_17235	COG0534	Mate efflux family protein
AA650_17270	COG0284	orotidine-5'-phosphate decarboxylase activity
AA650_17270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA650_17275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA650_17280	COG1104	cysteine desulfurase activity
AA650_17320	COG1487	ribonuclease activity
AA650_17370	COG0799	negative regulation of ribosome biogenesis
AA650_17390	COG1494	fructose-1,6-bisphosphatase
AA650_17395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA650_17415	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA650_17420	COG0724	RNA recognition motif
AA650_17435	COG1696	Membrane protein involved in D-alanine export
AA650_17445	COG1943	Transposase
AA650_17505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA650_17520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA650_17520	COG0574	Belongs to the PEP-utilizing enzyme family
AA650_17525	COG0469	pyruvate kinase activity
AA650_17530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA650_17540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AA650_17560	COG4680	protein conserved in bacteria
AA650_17580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA650_17585	COG0601	transmembrane transport
AA650_17610	COG0438	transferase activity, transferring glycosyl groups
AA650_17620	COG0438	transferase activity, transferring glycosyl groups
AA650_17625	COG3842	ATPase activity
AA650_17665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA650_17665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA650_17680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA650_17700	COG1027	Aspartate ammonia-lyase
AA650_17720	COG0438	transferase activity, transferring glycosyl groups
AA650_17760	COG1215	transferase activity, transferring glycosyl groups
AA650_17800	COG0003	Pfam Anion-transporting ATPase
AA650_17805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA650_17835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA650_17840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AA650_17845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA650_17860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_17865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_17870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_17870	COG1116	anion transmembrane transporter activity
AA650_17875	COG1116	anion transmembrane transporter activity
AA650_17880	COG4636	protein conserved in cyanobacteria
AA650_17920	COG1252	NADH dehydrogenase
AA650_17935	COG0398	Pfam SNARE associated Golgi protein
AA650_17960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA650_18000	COG1797	cobyrinic acid a,c-diamide synthase activity
AA650_18010	COG2201	protein-glutamate methylesterase activity
AA650_18015	COG2326	polyphosphate kinase activity
AA650_18020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_18035	COG0415	Belongs to the DNA photolyase family
AA650_18040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA650_18060	COG2203	Gaf domain
AA650_18080	COG2274	protein secretion by the type I secretion system
AA650_18095	COG0010	Belongs to the arginase family
AA650_18100	COG2264	protein methyltransferase activity
AA650_18105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA650_18110	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AA650_18115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA650_18140	COG1131	(ABC) transporter
AA650_18145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA650_18175	COG0084	hydrolase, TatD family'
AA650_18180	COG0268	Binds directly to 16S ribosomal RNA
AA650_18205	COG2119	membrane
AA650_18210	COG2226	methyltransferase
AA650_18225	COG0515	serine threonine protein kinase
AA650_18225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_18235	COG2226	methyltransferase
AA650_18240	COG0482	sulfurtransferase activity
AA650_18250	COG0424	maF-like protein
AA650_18275	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_18280	COG2886	Uncharacterised protein family (UPF0175)
AA650_18335	COG0633	Ferredoxin
AA650_18355	COG5420	small protein containing a coiled-coil domain
AA650_18370	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_18375	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_18380	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_18405	COG0582	viral genome integration into host DNA
AA650_18415	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_18455	COG4221	oxidoreductase activity
AA650_18470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA650_18550	COG3903	Transcriptional regulator
AA650_18550	COG2319	Wd-40 repeat
AA650_18560	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_18570	COG0582	viral genome integration into host DNA
AA650_18615	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AA650_18660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_18705	COG3119	arylsulfatase activity
AA650_18710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_18725	COG3385	transposase activity
AA650_18755	COG1132	(ABC) transporter
AA650_18760	COG0667	Aldo Keto reductase
AA650_18830	COG0625	glutathione transferase activity
AA650_18920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA650_18925	COG2873	o-acetylhomoserine
AA650_18930	COG0412	Dienelactone hydrolase
AA650_18935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_18940	COG4221	oxidoreductase activity
AA650_18950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_18955	COG1285	pathogenesis
AA650_18980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA650_18990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA650_18995	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_19020	COG0667	Aldo Keto reductase
AA650_19025	COG3659	wide pore channel activity
AA650_19030	COG0778	Nitroreductase
AA650_19050	COG2175	clavaminate synthase activity
AA650_19055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_19060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_19065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA650_19070	COG0431	NADPH-dependent FMN reductase
AA650_19095	COG0730	response to heat
AA650_19115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_19120	COG1959	2 iron, 2 sulfur cluster binding
AA650_19125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_19185	COG2906	2 iron, 2 sulfur cluster binding
AA650_19185	COG0822	iron-sulfur transferase activity
AA650_19185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA650_19190	COG1104	cysteine desulfurase activity
AA650_19210	COG1045	serine acetyltransferase
AA650_19225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA650_19230	COG5554	nitrogen fixation
AA650_19235	COG5554	nitrogen fixation
AA650_19255	COG0442	prolyl-tRNA aminoacylation
AA650_19260	COG0515	serine threonine protein kinase
AA650_19260	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_19285	COG0534	Mate efflux family protein
AA650_19290	COG1902	pentaerythritol trinitrate reductase activity
AA650_19295	COG4638	Rieske (2fe-2S)
AA650_19315	COG3321	synthase
AA650_19315	COG3321	synthase
AA650_19315	COG0604	alcohol dehydrogenase
AA650_19315	COG0604	alcohol dehydrogenase
AA650_19325	COG3321	synthase
AA650_19325	COG0604	alcohol dehydrogenase
AA650_19340	COG1960	acyl-CoA dehydrogenase activity
AA650_19360	COG0511	ligase activity, forming carbon-carbon bonds
AA650_19365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA650_19375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA650_19385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AA650_19395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA650_19400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA650_19410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA650_19420	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_19430	COG0358	DNA primase activity
AA650_19450	COG3385	transposase activity
AA650_19455	COG4585	Histidine kinase
AA650_19490	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AA650_19510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_19525	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA650_19555	COG0793	Belongs to the peptidase S41A family
AA650_19585	COG0019	diaminopimelate decarboxylase activity
AA650_19590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AA650_19595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA650_19630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA650_19635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA650_19640	COG0022	dehydrogenase e1 component
AA650_19640	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA650_19665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA650_19695	COG3385	transposase activity
AA650_19720	COG1063	alcohol dehydrogenase
AA650_19730	COG3311	Transcriptional regulator
AA650_19735	COG0515	serine threonine protein kinase
AA650_19735	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_19795	COG0495	leucyl-tRNA aminoacylation
AA650_19800	COG2124	cytochrome p450
AA650_19830	COG2267	carboxylic ester hydrolase activity
AA650_19840	COG4636	protein conserved in cyanobacteria
AA650_19870	COG3385	transposase activity
AA650_19900	COG4581	dead DEAH box helicase
AA650_19985	COG0612	Peptidase, M16
AA650_20045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_20060	COG0463	Glycosyl transferase, family 2
AA650_20080	COG0667	Aldo Keto reductase
AA650_20090	COG0352	thiamine-phosphate diphosphorylase activity
AA650_20120	COG1518	maintenance of DNA repeat elements
AA650_20120	COG1468	defense response to virus
AA650_20155	COG3385	transposase activity
AA650_20170	COG0154	amidase activity
AA650_20215	COG3240	lipase activity
AA650_20260	COG0584	glycerophosphoryl diester phosphodiesterase
AA650_20300	COG0501	Belongs to the peptidase M48B family
AA650_20305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA650_20330	COG0488	(ABC) transporter
AA650_20340	COG1132	(ABC) transporter
AA650_20350	COG0300	oxidoreductase activity
AA650_20350	COG3000	fatty acid hydroxylase
AA650_20355	COG4245	von Willebrand factor, type A
AA650_20410	COG1487	ribonuclease activity
AA650_20490	COG0556	nucleotide-excision repair
AA650_20500	COG4636	protein conserved in cyanobacteria
AA650_20525	COG0419	ATPase involved in DNA repair
AA650_20540	COG2223	nitrite transmembrane transporter activity
AA650_20570	COG1968	undecaprenyl-diphosphatase activity
AA650_20585	COG1555	photosystem II stabilization
AA650_20590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA650_20625	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA650_20630	COG4243	Vitamin k epoxide reductase
AA650_20635	COG0434	BtpA family
AA650_20640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA650_20645	COG0513	Belongs to the DEAD box helicase family
AA650_20685	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_20760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA650_20770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_20775	COG0735	belongs to the Fur family
AA650_20780	COG3773	Cell wall hydrolase
AA650_20780	COG3409	Peptidoglycan-binding domain 1 protein
AA650_20820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AA650_20835	COG0857	belongs to the CobB CobQ family
AA650_20890	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_20900	COG1215	transferase activity, transferring glycosyl groups
AA650_20930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_20955	COG0589	response to stress
AA650_20960	COG2205	protein histidine kinase activity
AA650_20975	COG0725	ABC transporter, periplasmic molybdate-binding protein
AA650_20980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA650_20985	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AA650_20995	COG0811	peptide transport
AA650_21000	COG0848	biopolymer transport protein
AA650_21015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AA650_21050	COG0793	Belongs to the peptidase S41A family
AA650_21090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA650_21105	COG0181	hydroxymethylbilane synthase activity
AA650_21110	COG0297	glycogen (starch) synthase activity
AA650_21120	COG0523	cobalamin synthesis protein
AA650_21145	COG4251	negative regulation of phosphorylation
AA650_21145	COG4251	negative regulation of phosphorylation
AA650_21150	COG0277	FAD linked oxidase domain protein
AA650_21155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_21165	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AA650_21170	COG4221	oxidoreductase activity
AA650_21175	COG0156	8-amino-7-oxononanoate synthase activity
AA650_21180	COG0632	four-way junction helicase activity
AA650_21190	COG0561	phosphatase activity
AA650_21245	COG1722	exodeoxyribonuclease VII activity
AA650_21290	COG0589	response to stress
AA650_21295	COG0126	phosphoglycerate kinase activity
AA650_21300	COG4636	protein conserved in cyanobacteria
AA650_21305	COG2208	phosphoserine phosphatase activity
AA650_21335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA650_21340	COG0805	protein transport
AA650_21375	COG0515	serine threonine protein kinase
AA650_21380	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_21380	COG0515	serine threonine protein kinase
AA650_21390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA650_21410	COG1012	belongs to the aldehyde dehydrogenase family
AA650_21420	COG0140	phosphoribosyl-ATP diphosphatase activity
AA650_21420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA650_21425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA650_21435	COG0515	serine threonine protein kinase
AA650_21435	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_21495	COG0037	tRNA processing
AA650_21505	COG0784	Response regulator, receiver
AA650_21530	COG2198	Histidine kinase
AA650_21530	COG0643	Histidine kinase
AA650_21530	COG2198	Histidine kinase
AA650_21530	COG0643	Histidine kinase
AA650_21545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA650_21550	COG0745	RESPONSE REGULATOR receiver
AA650_21565	COG1007	ATP synthesis coupled electron transport
AA650_21645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA650_21645	COG1754	DNA topoisomerase type I activity
AA650_21655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA650_21665	COG1480	7TM receptor with intracellular HD hydrolase
AA650_21705	COG0307	riboflavin synthase, alpha
AA650_21715	COG4942	peptidase
AA650_21720	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AA650_21720	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AA650_21750	COG0519	Catalyzes the synthesis of GMP from XMP
AA650_21750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA650_21755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AA650_21760	COG0189	ligase activity
AA650_21770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA650_21830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_21835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_21855	COG2890	protein-(glutamine-N5) methyltransferase activity
AA650_21860	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_21860	COG0515	serine threonine protein kinase
AA650_21875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA650_21895	COG0360	Binds together with S18 to 16S ribosomal RNA
AA650_21905	COG0587	DNA-directed DNA polymerase activity
AA650_21985	COG0542	response to heat
AA650_22010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA650_22015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA650_22020	COG1845	cytochrome c oxidase, subunit III
AA650_22035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA650_22045	COG2197	response regulator
AA650_22090	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AA650_22100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA650_22105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA650_22150	COG0436	Aminotransferase
AA650_22155	COG0371	Dehydrogenase
AA650_22195	COG1666	GTP binding
AA650_22200	COG0625	glutathione transferase activity
AA650_22230	COG1070	Carbohydrate kinase
AA650_22240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA650_22280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA650_22285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA650_22290	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AA650_22295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA650_22300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA650_22305	COG0646	methionine synthase
AA650_22305	COG1410	methionine synthase
AA650_22315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA650_22330	COG1012	belongs to the aldehyde dehydrogenase family
AA650_22360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA650_22365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AA650_22370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA650_22375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA650_22385	COG0740	serine-type endopeptidase activity
AA650_22390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA650_22480	COG1836	PFAM Integral membrane protein DUF92
AA650_22495	COG1940	carbohydrate kinase activity
AA650_22520	COG2082	Precorrin-8x methylmutase
AA650_22530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA650_22590	COG0343	queuine tRNA-ribosyltransferase activity
AA650_22635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_22655	COG0667	Aldo Keto reductase
AA650_22660	COG0537	adenosine 5'-monophosphoramidase activity
AA650_22680	COG0606	chelatase, subunit chli
AA650_22685	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AA650_22700	COG0673	inositol 2-dehydrogenase activity
AA650_22715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA650_22730	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_22730	COG0515	serine threonine protein kinase
AA650_22765	COG0401	homolog of Blt101
AA650_22770	COG0023	Translation Initiation Factor
AA650_22775	COG2161	toxin-antitoxin pair type II binding
AA650_22790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AA650_22795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA650_22810	COG0768	penicillin binding
AA650_22840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA650_22870	COG0191	fructose-bisphosphate aldolase activity
AA650_22910	COG1122	ATPase activity
AA650_22925	COG1247	-acetyltransferase
AA650_22930	COG0746	molybdenum cofactor guanylyltransferase activity
AA650_22935	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA650_22940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA650_22945	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AA650_22950	COG2080	2 iron, 2 sulfur cluster binding
AA650_22970	COG1649	PFAM Uncharacterised BCR, COG1649
AA650_22990	COG0535	radical SAM domain protein
AA650_23035	COG0497	DNA recombination
AA650_23055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA650_23080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA650_23085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA650_23105	COG0501	Belongs to the peptidase M48B family
AA650_23145	COG1396	sequence-specific DNA binding
AA650_23150	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AA650_23155	COG4636	protein conserved in cyanobacteria
AA650_23160	COG0300	oxidoreductase activity
AA650_23185	COG0302	gtp cyclohydrolase
AA650_23190	COG0523	cobalamin synthesis protein
AA650_23200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA650_23230	COG0113	porphobilinogen synthase activity
AA650_23235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_23235	COG2022	thiamine diphosphate biosynthetic process
AA650_23250	COG1376	ErfK ybiS ycfS ynhG family protein
AA650_23250	COG1388	LysM domain
AA650_23255	COG1595	DNA-templated transcription, initiation
AA650_23315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA650_23320	COG0745	RESPONSE REGULATOR receiver
AA650_23325	COG4636	protein conserved in cyanobacteria
AA650_23335	COG0829	nickel cation binding
AA650_23340	COG0831	urea catabolic process
AA650_23355	COG0832	Belongs to the urease beta subunit family
AA650_23360	COG0804	urea catabolic process
AA650_23365	COG0739	heme binding
AA650_23375	COG1131	(ABC) transporter
AA650_23385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA650_23405	COG0017	Asparaginyl-tRNA synthetase
AA650_23420	COG0515	serine threonine protein kinase
AA650_23420	COG3266	domain, Protein
AA650_23430	COG3385	transposase activity
AA650_23440	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AA650_23445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA650_23455	COG0228	four-way junction DNA binding
AA650_23465	COG1702	phosphate starvation-inducible protein PhoH
AA650_23550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA650_23555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AA650_23560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA650_23565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA650_23575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA650_23580	COG0356	it plays a direct role in the translocation of protons across the membrane
AA650_23590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_23605	COG3385	transposase activity
AA650_23625	COG0765	amino acid transport
AA650_23640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA650_23675	COG2226	methyltransferase
AA650_23680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_23695	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_23700	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_23730	COG3903	Transcriptional regulator
AA650_23730	COG2319	Wd-40 repeat
AA650_23735	COG2988	succinylglutamate desuccinylase activity
AA650_23740	COG0438	transferase activity, transferring glycosyl groups
AA650_23750	COG2319	Wd-40 repeat
AA650_23755	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AA650_23760	COG3906	Belongs to the UPF0473 family
AA650_23785	COG0793	Belongs to the peptidase S41A family
AA650_23790	COG2045	Belongs to the ComB family
AA650_23795	COG2363	Small membrane protein
AA650_23805	COG0390	transport system, permease component
AA650_23830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA650_23840	COG5002	protein histidine kinase activity
AA650_23865	COG0438	transferase activity, transferring glycosyl groups
AA650_23870	COG1216	Glycosyl transferase, family 2
AA650_23875	COG1132	(ABC) transporter
AA650_23890	COG0489	protein tyrosine kinase activity
AA650_23920	COG1216	Glycosyl transferase, family 2
AA650_23925	COG1216	Glycosyl transferase, family 2
AA650_23930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA650_23935	COG0579	oxidoreductase
AA650_23940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA650_23960	COG4245	von Willebrand factor, type A
AA650_23965	COG0784	Response regulator, receiver
AA650_24045	COG1690	Belongs to the RtcB family
AA650_24065	COG0113	porphobilinogen synthase activity
AA650_24075	COG0735	belongs to the Fur family
AA650_24080	COG0678	peroxiredoxin activity
AA650_24125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA650_24130	COG0166	Belongs to the GPI family
AA650_24150	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_24155	COG1160	GTP binding
AA650_24215	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AA650_24225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AA650_24230	COG0501	Belongs to the peptidase M48B family
AA650_24240	COG0297	glycogen (starch) synthase activity
AA650_24260	COG3659	wide pore channel activity
AA650_24265	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA650_24270	COG1121	(ABC) transporter
AA650_24275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA650_24350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA650_24370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AA650_24390	COG0339	signal peptide processing
AA650_24425	COG1429	ligase activity, forming nitrogen-metal bonds
AA650_24435	COG4636	protein conserved in cyanobacteria
AA650_24550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA650_24565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_24570	COG1937	Protein conserved in bacteria
AA650_24590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AA650_24645	COG0024	Methionine aminopeptidase
AA650_24650	COG0673	inositol 2-dehydrogenase activity
AA650_24685	COG0633	Ferredoxin
AA650_24690	COG2385	sporulation resulting in formation of a cellular spore
AA650_24700	COG1366	Belongs to the anti-sigma-factor antagonist family
AA650_24705	COG0745	RESPONSE REGULATOR receiver
AA650_24740	COG1185	polyribonucleotide nucleotidyltransferase activity
AA650_24810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA650_24830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA650_24835	COG0193	aminoacyl-tRNA hydrolase activity
AA650_24845	COG1216	Glycosyl transferase, family 2
AA650_24855	COG0586	Pfam SNARE associated Golgi protein
AA650_24870	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AA650_24890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA650_24895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA650_24900	COG1943	Transposase
AA650_24905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_24915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_24935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA650_24940	COG0210	DNA helicase
AA650_24955	COG2815	serine threonine protein kinase
AA650_24955	COG0515	serine threonine protein kinase
AA650_24970	COG4399	Belongs to the UPF0754 family
AA650_24980	COG0426	domain, Protein
AA650_24980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_24985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_24985	COG0426	domain, Protein
AA650_24995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA650_24995	COG2755	lipolytic protein G-D-S-L family
AA650_25010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_25040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA650_25065	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_25095	COG0542	response to heat
AA650_25100	COG0346	lactoylglutathione lyase activity
AA650_25115	COG0653	protein targeting
AA650_25125	COG2010	Cytochrome c
AA650_25135	COG0742	ribosomal rna small subunit methyltransferase
AA650_25145	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AA650_25160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA650_25165	COG0438	transferase activity, transferring glycosyl groups
AA650_25175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AA650_25180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_25185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA650_25190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_25215	COG0745	RESPONSE REGULATOR receiver
AA650_25290	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_25315	COG1429	ligase activity, forming nitrogen-metal bonds
AA650_25395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA650_25410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA650_25415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AA650_25425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA650_25430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_25435	COG2048	Heterodisulfide reductase, subunit B
AA650_25440	COG0242	peptide deformylase activity
AA650_25450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_25550	COG1309	transcriptional regulator
AA650_25555	COG1136	(ABC) transporter
AA650_25580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_25650	COG4974	Belongs to the 'phage' integrase family
AA650_25705	COG1475	DNA binding
AA650_25710	COG1192	Involved in chromosome partitioning
AA650_25715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA650_25815	COG4474	Belongs to the UPF0398 family