locus-tag class description EH233_00010 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EH233_00025 ENOG4105C59 p-type ATPase EH233_00045 ENOG41081FY multiple antibiotic resistance (MarC)-related EH233_00055 ENOG4105C5R Aminotransferase EH233_00060 ENOG4105E2K Glycosyl transferase (Group 1 EH233_00070 ENOG4105D38 putrescine abc transporter EH233_00115 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EH233_00165 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EH233_00180 ENOG4108ZFD Antibiotic biosynthesis monooxygenase EH233_00185 ENOG4105CHJ isochorismatase hydrolase EH233_00190 ENOG4105CNF WD-40 repeat protein EH233_00205 ENOG4105EPW hflc protein EH233_00215 ENOG410841Q phosphoesterase PA-phosphatase related protein EH233_00220 ENOG4107TSN permease EH233_00230 ENOG4105DUM transcriptional regulator, lysR family EH233_00270 ENOG4105FBW Monooxygenase EH233_00290 ENOG4105GVF (ABC) transporter EH233_00300 ENOG4107MKT Stringent starvation protein a EH233_00305 ENOG4105CPC Aldo Keto reductase EH233_00325 ENOG4107MKT Stringent starvation protein a EH233_00340 ENOG4105GVF (ABC) transporter EH233_00345 ENOG4105GVF (ABC) transporter EH233_00355 ENOG4107QZT geranylgeranyl reductase EH233_00370 ENOG4107MKT Stringent starvation protein a EH233_00380 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EH233_00400 ENOG4105BZ1 (ABC) transporter EH233_00410 ENOG4108JQ6 ABC transporter EH233_00440 ENOG4108JJB ABC transporter EH233_00460 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EH233_00470 ENOG4105EHV domain protein EH233_00485 ENOG4105QYV Membrane EH233_00515 ENOG4105D7V transposase EH233_00540 ENOG4105D05 Receptor EH233_00590 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) EH233_00665 ENOG4108Z6B deaminase EH233_00670 ENOG4105C8T Leucyl-tRNA synthetase EH233_00685 ENOG4105EMN RNA polymerase sigma factor EH233_00695 ENOG4108PXI ErfK YbiS YcfS YnhG EH233_00705 ENOG4105E4C Lytic transglycosylase catalytic EH233_00710 ENOG4105BZU Histidine kinase EH233_00715 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EH233_00720 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EH233_00725 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EH233_00750 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EH233_00760 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EH233_00775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_00810 ENOG4105WQ3 Rna-binding protein EH233_00815 ENOG4105CHR reductase EH233_00850 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EH233_00860 ENOG4105EHG Permease protein EH233_00865 ENOG4108UXN response regulator EH233_00885 ENOG4105DK0 Indole-3-glycerol phosphate synthase EH233_00895 ENOG4105CRQ synthase (Component I) EH233_00900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_00910 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EH233_00915 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EH233_00960 ENOG4105EGD dinuclear metal center protein, YbgI family EH233_00995 ENOG4105MZG transcriptional modulator of maze toxin, mazf EH233_01010 ENOG4105C9B Cysteine desulfurase EH233_01040 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EH233_01050 ENOG4105PW4 Sugar fermentation stimulation protein homolog EH233_01055 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EH233_01065 ENOG4107QI6 Cysteine desulfurase EH233_01110 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) EH233_01125 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family EH233_01130 ENOG4105CGN Glycosyl transferase (Group 1 EH233_01135 ENOG4105VFN O-Antigen polymerase EH233_01140 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_01165 ENOG4105FAT Acyl-transferase EH233_01185 ENOG4105D3Q Sugar transferase EH233_01210 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EH233_01225 ENOG4108JJA ABC, transporter EH233_01230 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EH233_01240 ENOG4107GBW cellulosome anchoring protein cohesin EH233_01250 ENOG4105CJ1 ABC, transporter EH233_01275 ENOG4105C59 p-type ATPase EH233_01305 ENOG4105DZR Type I site-specific deoxyribonuclease EH233_01325 ENOG4105CVR type I restriction-modification system EH233_01325 ENOG4105CVR type I restriction-modification system EH233_01350 ENOG4108YN7 fruiting body developmental protein EH233_01355 ENOG4108R5Z fruiting body developmental protein EH233_01395 ENOG4107SWG transcriptional regulator MERR family EH233_01400 ENOG4105C5I Dehydrogenase EH233_01405 ENOG4105E6M Sulphatase-modifying factor protein EH233_01410 ENOG41061MV Arylsulfatase EH233_01430 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB EH233_01435 ENOG4105C3J Cysteine desulfurase EH233_01450 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) EH233_01460 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain EH233_01470 ENOG4105D0B Nitrogenase protein alpha chain EH233_01475 ENOG4108UR2 Nitrogen fixation protein NifX EH233_01480 ENOG4108VQE nitrogen fixation protein EH233_01485 ENOG4105X87 nitrogen fixation EH233_01490 ENOG4106C8Q May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) EH233_01495 ENOG41081QJ UBA THIF-type NAD FAD binding EH233_01500 ENOG4108Z4V iron-sulfur cluster assembly EH233_01510 ENOG4105WCA Ferredoxin EH233_01540 ENOG4107QRI Phosphoketolase EH233_01600 ENOG4108JYK Dehydrogenase EH233_01625 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process EH233_01630 ENOG41067HS methyltransferase EH233_01660 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_01680 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EH233_01690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EH233_01700 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EH233_01745 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EH233_01760 ENOG4105BZU Histidine kinase EH233_01770 ENOG4105N7N Pentapeptide repeat-containing protein EH233_01775 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EH233_01790 ENOG4105C1V Peptidase, M16 EH233_01800 ENOG41086DT Membrane protein of unknown function EH233_01835 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EH233_01845 ENOG4105NAE bifunctional deaminase-reductase domain protein EH233_01850 ENOG4105VPX protein, conserved in bacteria EH233_01865 ENOG4105BZU Histidine kinase EH233_01870 ENOG4105ES5 Histidine kinase EH233_01885 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EH233_01895 ENOG4105CPU Monooxygenase EH233_01910 ENOG4107XGZ Hydrolase EH233_01920 ENOG4105CIH Imidazole acetol-phosphate transaminase EH233_01925 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EH233_01945 ENOG4105XEV csbD-like EH233_01955 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EH233_02015 ENOG4105CYM Glutathione S-transferase EH233_02030 ENOG4105BZU Histidine kinase EH233_02040 ENOG4105F8J Adenylate Guanylate cyclase EH233_02045 ENOG4107SBE Glycosyl transferase (Group 1 EH233_02055 ENOG4105BZU Histidine kinase EH233_02060 ENOG4105BZU Histidine kinase EH233_02080 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EH233_02090 ENOG4108MUZ hydrolase EH233_02115 ENOG4107Z6A sulfate abc transporter permease EH233_02120 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EH233_02125 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EH233_02150 ENOG4105E7A Glutamine amidotransferase EH233_02160 ENOG4108XKD photosystem i EH233_02165 ENOG4105BZU Histidine kinase EH233_02185 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EH233_02225 ENOG4105BZS acriflavin resistance protein EH233_02250 ENOG4105SUT Transcriptional Regulator AraC Family EH233_02255 ENOG4107SQU synthase EH233_02260 ENOG4107EEY synthase EH233_02265 ENOG4108JA1 polyketide synthase EH233_02275 ENOG4108JA1 polyketide synthase EH233_02295 ENOG4107QKG PfaD family EH233_02310 ENOG4108ZAF Molybdopterin EH233_02320 ENOG4108K5P (LipO)protein EH233_02330 ENOG4105CHR reductase EH233_02335 ENOG4108TVJ Nitroreductase EH233_02340 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EH233_02345 ENOG4105K63 Thioredoxin EH233_02350 ENOG4105YVS arsR family transcriptional regulator EH233_02400 ENOG4105C59 p-type ATPase EH233_02410 ENOG4108V9Q carbonic anhydrase EH233_02415 ENOG4107R0W ABC transporter EH233_02420 ENOG4108IV0 ABC, transporter EH233_02430 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EH233_02435 ENOG410811H Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EH233_02440 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EH233_02470 ENOG4105DTD Dehydrogenase EH233_02490 ENOG41081UC Inherit from COG: Competence protein EH233_02500 ENOG4105VFU Rna-binding protein EH233_02505 ENOG4108UHE carbonic anhydrase EH233_02535 ENOG4105CA3 membrane-bound lytic murein transglycosylase EH233_02540 ENOG4105CSV Glutaminase EH233_02545 ENOG4105K6T rare lipoprotein A EH233_02550 ENOG4105CAT Cytidine monophosphate kinase EH233_02555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EH233_02565 ENOG4105DB7 PHP domain protein EH233_02580 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) EH233_02585 ENOG4108DJF Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EH233_02615 ENOG4105CB5 ATP-dependent DNA helicase recG EH233_02620 ENOG4108JQC penicillin-binding protein 1A EH233_02660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EH233_02670 ENOG4105CVP deoxyribo-dipyrimidine photolyase EH233_02680 ENOG4107S73 homocitrate synthase EH233_02705 ENOG4105CHC glucokinase (EC 2.7.1.2) EH233_02740 ENOG4108JQC penicillin-binding protein 1A EH233_02745 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EH233_02750 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EH233_02760 ENOG4105FFC UPF0187 protein EH233_02770 ENOG4107VAM peptidase, m28 EH233_02775 ENOG4108KBA Acts as a chaperone (By similarity) EH233_02805 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EH233_02810 ENOG4105C8B TIGR00159 family EH233_02820 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EH233_02905 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) EH233_02915 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EH233_02925 ENOG4105D64 Mechanosensitive ion channel EH233_02955 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EH233_02960 ENOG4105CH5 extracellular solute-binding protein, family 7 EH233_02970 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EH233_02995 ENOG4105D7T ABC transporter EH233_03010 ENOG4105BZU Histidine kinase EH233_03030 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EH233_03035 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EH233_03040 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase EH233_03065 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase EH233_03095 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EH233_03100 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EH233_03130 ENOG41067S7 ribulose bisphosphate carboxylase EH233_03145 ENOG4108VFZ ribulose bisphosphate carboxylase, small EH233_03155 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EH233_03165 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EH233_03175 ENOG4107R7I amino acid EH233_03190 ENOG4108AC1 4fe-4s ferredoxin, iron-sulfur binding EH233_03195 ENOG4105C3J Cysteine desulfurase EH233_03205 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) EH233_03210 ENOG4105D0B Nitrogenase protein alpha chain EH233_03235 ENOG4105JZI cytochrome P450 EH233_03240 ENOG4108S59 EH233_03275 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain EH233_03285 ENOG4105D0B Nitrogenase protein alpha chain EH233_03290 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN EH233_03295 ENOG4108UR2 Nitrogen fixation protein NifX EH233_03300 ENOG4108VQE nitrogen fixation protein EH233_03305 ENOG4105X87 nitrogen fixation EH233_03310 ENOG4105R88 May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) EH233_03315 ENOG41081QJ UBA THIF-type NAD FAD binding EH233_03320 ENOG4105V5Z Iron-sulfur cluster assembly accessory protein EH233_03335 ENOG4105F4R Transcriptional regulator mode EH233_03390 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EH233_03410 ENOG4107S73 homocitrate synthase EH233_03445 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EH233_03460 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EH233_03465 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EH233_03470 ENOG4108W6C Dehydrogenase EH233_03475 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EH233_03480 ENOG4108RU0 short-chain dehydrogenase reductase EH233_03505 ENOG4105BZU Histidine kinase EH233_03510 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_03530 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase EH233_03555 ENOG4107EEY synthase EH233_03565 ENOG4105CEY Amp-dependent synthetase and ligase EH233_03570 ENOG4105C84 Histidine ammonia-lyase EH233_03615 ENOG4105D9P serine threonine protein kinase EH233_03620 ENOG4105CGH 5'-nucleotidase EH233_03690 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin EH233_03715 ENOG4105DFK Polyphosphate glucokinase EH233_03725 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EH233_03730 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EH233_03735 ENOG4106H78 methyltransferase EH233_03755 ENOG4105E66 phosphoriboisomerase A EH233_03765 ENOG4105D9P serine threonine protein kinase EH233_03770 ENOG4107JEG This protein is a component of the reaction center of photosystem II (By similarity) EH233_03780 ENOG4106DDF Photosystem II reaction center protein M EH233_03795 ENOG4105DGW oligopeptidase A EH233_03810 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 EH233_03825 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) EH233_03840 ENOG4105C8S subunit m EH233_03845 ENOG4105D65 subunit l EH233_03855 ENOG4108WT6 Carbon dioxide concentrating mechanism protein EH233_03860 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml EH233_03870 ENOG4105MXK Carbon dioxide concentrating mechanism protein EH233_03875 ENOG4105MN7 Carbon dioxide concentrating mechanism protein EH233_03885 ENOG4105DUM transcriptional regulator, lysR family EH233_03900 ENOG4107U7Q Transfers the fatty acyl group on membrane lipoproteins (By similarity) EH233_03930 ENOG4105BZU Histidine kinase EH233_03945 ENOG4105E5G Alpha beta hydrolase fold EH233_03965 ENOG410686T photosystem II reaction center protein N EH233_03970 ENOG4105WIA photosystem II reaction center protein H EH233_03975 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EH233_03980 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EH233_03985 ENOG410848W 30S ribosomal protein S21 EH233_04020 ENOG4108PWY Carbohydrate-selective porin OprB EH233_04025 ENOG4105DSE periplasmic solute binding protein EH233_04030 ENOG4105FDK ABC transporter EH233_04040 ENOG4105FAV ABC, transporter EH233_04060 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EH233_04070 ENOG4105BZU Histidine kinase EH233_04075 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EH233_04095 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EH233_04100 ENOG4105D5K Hemolysin activator protein EH233_04105 ENOG4105BZU Histidine kinase EH233_04110 ENOG41084UD rubredoxin EH233_04115 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction EH233_04155 ENOG4107Z8Z Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EH233_04160 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EH233_04180 ENOG41082AN stage II sporulation protein EH233_04185 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EH233_04195 ENOG4107RNB anthranilate phosphoribosyltransferase EH233_04280 ENOG4105D9P serine threonine protein kinase EH233_04290 ENOG4107QSQ Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EH233_04305 ENOG4105D49 3-dehydroquinate synthase EH233_04310 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EH233_04325 ENOG4107Z8V Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EH233_04340 ENOG4105D7N magnesium and cobalt transport protein CorA EH233_04345 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EH233_04350 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EH233_04355 ENOG4105BZU Histidine kinase EH233_04360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_04395 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EH233_04405 ENOG4107SC0 ferredoxin--NADP reductase EH233_04415 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EH233_04440 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) EH233_04455 ENOG4105BZA Phosphoglycerate kinase EH233_04535 ENOG4105JFG SpoIID LytB domain protein EH233_04540 ENOG410811Q Ferredoxin EH233_04545 ENOG4105D9R oxidoreductase EH233_04565 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) EH233_04570 ENOG4107XWB Zinc finger, swim domain protein EH233_04575 ENOG4105D65 subunit l EH233_04580 ENOG4105C8S subunit m EH233_04600 ENOG4105D3Q Sugar transferase EH233_04605 ENOG4107WPW Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EH233_04620 ENOG4107QXX ABC transporter EH233_04625 ENOG4105EZ7 amino acid ABC transporter EH233_04630 ENOG4105DRP amino acid AbC transporter EH233_04635 ENOG4105CDA abc transporter atp-binding protein EH233_04640 ENOG4106CD9 glycosyl transferase group 1 EH233_04675 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EH233_04680 ENOG4107XHR Involved in DNA repair and RecF pathway recombination (By similarity) EH233_04690 ENOG4108KMV Glycosyl transferase (Group 1 EH233_04710 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EH233_04715 ENOG4105C5H ABC transporter EH233_04730 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EH233_04735 ENOG41082HT Binds the 23S rRNA (By similarity) EH233_04740 ENOG4108UJD 30S ribosomal protein S9 EH233_04745 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EH233_04750 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EH233_04755 ENOG4108ZT0 50S ribosomal protein l17 EH233_04760 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EH233_04765 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EH233_04770 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EH233_04775 ENOG41067V7 50S ribosomal protein L36 EH233_04785 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EH233_04790 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EH233_04795 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EH233_04800 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EH233_04805 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EH233_04810 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EH233_04815 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EH233_04820 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EH233_04825 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EH233_04830 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EH233_04835 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EH233_04840 ENOG410848H 50s ribosomal protein l29 EH233_04845 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EH233_04850 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EH233_04855 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EH233_04860 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EH233_04870 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EH233_04875 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EH233_04880 ENOG4108USA electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) EH233_04905 ENOG4105D74 hydrolase EH233_04910 ENOG4107NA1 Endonuclease Exonuclease phosphatase EH233_04920 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EH233_04925 ENOG4105CPC Aldo Keto reductase EH233_04935 ENOG4105BZU Histidine kinase EH233_04950 ENOG4105C7B Threonine dehydratase EH233_04965 ENOG4106F1P AAA ATPase, central domain protein EH233_04970 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EH233_04985 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EH233_05035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_05060 ENOG4105CJ1 ABC, transporter EH233_05105 ENOG4105DFF Rod shape-determining protein mreb EH233_05110 ENOG41080E3 single-stranded DNA-binding protein EH233_05125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EH233_05130 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase EH233_05135 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EH233_05180 ENOG4105KC4 UPF0296 protein EH233_05190 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EH233_05195 ENOG4108W6I photosystem I reaction center protein subunit XI EH233_05200 ENOG4106AST May help in the organization of the PsaE and PsaF subunits (By similarity) EH233_05205 ENOG4108VV8 photosystem i EH233_05210 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EH233_05245 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EH233_05250 ENOG4105BZU Histidine kinase EH233_05265 ENOG4108JIS Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EH233_05295 ENOG4108IJ6 ABC transporter EH233_05310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_05345 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EH233_05355 ENOG4105YVZ photosystem II EH233_05365 ENOG4105DEF Extracellular solute-binding protein, family 5 EH233_05370 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EH233_05375 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EH233_05395 ENOG4105K46 50S ribosomal protein l27 EH233_05400 ENOG41082FX This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EH233_05420 ENOG4105EET magnesium chelatase EH233_05425 ENOG4105FQP Beta-lactamase EH233_05455 ENOG4107T8Q Glycosyl transferase (Group 1 EH233_05460 ENOG4105CPK Glycosyl transferase (Group 1 EH233_05470 ENOG4105TQG cytochrome C, class I EH233_05485 ENOG41086DT Membrane protein of unknown function EH233_05495 ENOG4105BZM domain protein EH233_05505 ENOG4107SKI cobyrinic Acid a,c-diamide synthase EH233_05545 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EH233_05570 ENOG4105C59 p-type ATPase EH233_05610 ENOG4108HMN Caspase domain EH233_05620 ENOG4105C0Z ABC transporter EH233_05635 ENOG4105C32 Amino acid ABC transporter (Permease) EH233_05650 ENOG4108W3Y Transcriptional regulator, Crp Fnr family EH233_05665 ENOG4108UR2 Nitrogen fixation protein NifX EH233_05710 ENOG4105ND9 Nitrogenase-associated protein EH233_05740 ENOG4105WCA Ferredoxin EH233_05760 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EH233_05765 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EH233_05780 ENOG4105C3J Cysteine desulfurase EH233_05790 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EH233_05795 ENOG4105D9P serine threonine protein kinase EH233_05800 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EH233_05815 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EH233_05820 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EH233_05865 ENOG41080XM UPF0145 protein EH233_05875 ENOG4105CJ1 ABC, transporter EH233_05905 ENOG4105BZU Histidine kinase EH233_05915 ENOG4108KGH TRANSCRIPTIONal EH233_05935 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EH233_05985 ENOG4105WGP Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity) EH233_06025 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EH233_06050 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EH233_06055 ENOG4105D1D Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EH233_06065 ENOG4107RFW hydrolase family 57 EH233_06070 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EH233_06080 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EH233_06085 ENOG4105CFG Acts as a chaperone (By similarity) EH233_06090 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EH233_06095 ENOG4107QHF type ii secretion system protein e EH233_06100 ENOG4105CZX twitching motility protein EH233_06180 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_06200 ENOG4107QRP cobalamin biosynthesis protein CobW EH233_06230 ENOG410812K response regulator receiver protein EH233_06245 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EH233_06255 ENOG4105C6X Major Facilitator EH233_06260 ENOG4105CKK Glycosyl transferase, family 2 EH233_06280 ENOG4108KS2 transglutaminase domain protein EH233_06285 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EH233_06290 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EH233_06300 ENOG4108302 MgtC SapB transporter EH233_06305 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EH233_06315 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EH233_06335 ENOG4108ZF3 Phosphatase EH233_06355 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase EH233_06360 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EH233_06385 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EH233_06400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_06405 ENOG4105EB3 Histidine kinase EH233_06415 ENOG4108W3Y Transcriptional regulator, Crp Fnr family EH233_06420 ENOG4108PWY Carbohydrate-selective porin OprB EH233_06435 ENOG4105BZU Histidine kinase EH233_06445 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_06450 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EH233_06465 ENOG4107V9E glucose-1-phosphate thymidylyltransferase EH233_06470 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EH233_06475 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EH233_06485 ENOG4108IAJ Nad-dependent epimerase dehydratase EH233_06490 ENOG4105CKK Glycosyl transferase, family 2 EH233_06500 ENOG4107RGC Glycosyl transferase, family 2 EH233_06505 ENOG4107RGC Glycosyl transferase, family 2 EH233_06510 ENOG4105EY8 ABC transporter EH233_06535 ENOG4105D0U Arsenite-activated ATPase (ArsA) EH233_06540 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase EH233_06545 ENOG4105IJJ transcriptional regulator, crp fnr family EH233_06555 ENOG4105CHR reductase EH233_06580 ENOG4105ECY inositol monophosphatase EH233_06585 ENOG4105XCI PucC protein EH233_06595 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EH233_06610 ENOG4107TCE N-acetyltransferase EH233_06655 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth EH233_06660 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth EH233_06675 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) EH233_06680 ENOG4108XNA Gas vesicle EH233_06710 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EH233_06720 ENOG4105BZU Histidine kinase EH233_06725 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EH233_06740 ENOG4105CBS Chea signal transduction histidine kinase EH233_06745 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EH233_06755 ENOG4105M3Z response regulator EH233_06765 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EH233_06770 ENOG4108E1C hydrolase EH233_06775 ENOG4105BZU Histidine kinase EH233_06810 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EH233_06815 ENOG4105E2Z phosphate ABC transporter (Permease EH233_06820 ENOG4105C8U phosphate abc transporter EH233_06825 ENOG4105PWN phosphate abc transporter EH233_06830 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EH233_06855 ENOG4108HMN Caspase domain EH233_06865 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EH233_06885 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EH233_06905 ENOG4105VFU Rna-binding protein EH233_06910 ENOG41080HI glycine oxidase EH233_06930 ENOG4105E0F Histidine kinase EH233_06935 ENOG4105C01 Dihydroxy-acid dehydratase EH233_06940 ENOG4105CKK Glycosyl transferase, family 2 EH233_06945 ENOG4105DWF phosphomethylpyrimidine kinase EH233_06965 ENOG4107YCR Transcriptional regulator, ARSR family EH233_06970 ENOG4105CHM Aminotransferase EH233_07030 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EH233_07040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EH233_07045 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EH233_07050 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EH233_07065 ENOG4105E4F Isochorismate synthase EH233_07070 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EH233_07080 ENOG4105CNF WD-40 repeat protein EH233_07105 ENOG41063JG Transcriptional regulator EH233_07110 ENOG4105W5K Rod linker protein, associated with allophycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer (By similarity) EH233_07115 ENOG4105FBM allophycocyanin beta subunit EH233_07120 ENOG4108MAQ allophycocyanin alpha EH233_07125 ENOG4105EEK Polypeptide EH233_07135 ENOG4107SWE Methyltransferase EH233_07140 ENOG4105PA3 atp synthase EH233_07145 ENOG4107SM1 it plays a direct role in the translocation of protons across the membrane (By similarity) EH233_07150 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EH233_07155 ENOG4105S30 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EH233_07160 ENOG4105VYJ F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EH233_07165 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EH233_07170 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EH233_07175 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EH233_07205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EH233_07235 ENOG4108JQ9 ABC transporter EH233_07250 ENOG4108W6C Dehydrogenase EH233_07260 ENOG4107P5I polyketide synthase EH233_07265 ENOG4107QKG PfaD family EH233_07270 ENOG4107SQU synthase EH233_07280 ENOG4105C0W non-ribosomal peptide synthetase EH233_07285 ENOG4108JA1 polyketide synthase EH233_07300 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) EH233_07345 ENOG4108SMZ Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) EH233_07350 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EH233_07405 ENOG4106JD1 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 (By similarity) EH233_07425 ENOG4105BZU Histidine kinase EH233_07430 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_07440 ENOG4107SBE Glycosyl transferase (Group 1 EH233_07455 ENOG4105CNW domain protein EH233_07465 ENOG4105CNW domain protein EH233_07475 ENOG4105CH7 arginosuccinase EH233_07485 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase EH233_07490 ENOG4107QRA Extracellular solute-binding protein, family 5 EH233_07495 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EH233_07500 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EH233_07505 ENOG4105DDG Cyanophycinase EH233_07510 ENOG4107RRY Cyanophycin synthetase EH233_07515 ENOG41063NY Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EH233_07525 ENOG4107WDG serine threonine protein kinase EH233_07530 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase EH233_07575 ENOG4105C9B Cysteine desulfurase EH233_07590 ENOG4105D7V transposase EH233_07595 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EH233_07615 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EH233_07625 ENOG4105D7Z glutathione synthase EH233_07630 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EH233_07650 ENOG4108HMN Caspase domain EH233_07660 ENOG4105CPJ photosystem II manganese-stabilizing EH233_07710 ENOG4106DN3 This protein is a component of the reaction center of photosystem II (By similarity) EH233_07720 ENOG410689D This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) EH233_07725 ENOG4105NT3 This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) EH233_07730 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity EH233_07735 ENOG410828V rubredoxin EH233_07740 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EH233_07745 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EH233_07750 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EH233_07765 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EH233_07785 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EH233_07795 ENOG4105CHV Transcription elongation factor NusA EH233_07800 ENOG4107ZR3 Required for maturation of 30S ribosomal subunits (By similarity) EH233_07905 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EH233_07910 ENOG4105CE9 30S ribosomal protein S2 EH233_07925 ENOG4107R51 Glycosyl transferase, family 2 EH233_07945 ENOG4105CDH Citrulline--aspartate ligase EH233_07955 ENOG41082AN stage II sporulation protein EH233_07965 ENOG41082BG Binds together with S18 to 16S ribosomal RNA (By similarity) EH233_07970 ENOG4105ERH Fumarylacetoacetate hydrolase EH233_07985 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EH233_07990 ENOG4105ESV Glycosyl transferase, family 4 EH233_07995 ENOG4105CEV competence damage-inducible protein EH233_08015 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EH233_08025 ENOG4107WDG serine threonine protein kinase EH233_08045 ENOG4105KRQ Addiction module toxin, Txe YoeB family EH233_08055 ENOG4107R4J Chloride channel EH233_08075 ENOG4105D3Q Sugar transferase EH233_08080 ENOG4105DRS transport system, permease EH233_08085 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EH233_08095 ENOG4105C0K Gdp-mannose 4,6-dehydratase EH233_08100 ENOG4105D3Q Sugar transferase EH233_08105 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_08110 ENOG4105CMR udp-glucose 4-epimerase EH233_08120 ENOG4105JZI cytochrome P450 EH233_08125 ENOG4108HMN Caspase domain EH233_08160 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EH233_08165 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EH233_08175 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EH233_08180 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EH233_08185 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EH233_08190 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EH233_08200 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EH233_08220 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EH233_08225 ENOG4108JA2 transcriptioN-repair coupling factor EH233_08250 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase EH233_08255 ENOG4107TVC Glycosyl transferase, family 2 EH233_08270 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) EH233_08285 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EH233_08375 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_08380 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_08385 ENOG4105BZU Histidine kinase EH233_08400 ENOG4105D8X mechanosensitive ion channel EH233_08435 ENOG4108IUZ ABC transporter EH233_08460 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EH233_08475 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EH233_08480 ENOG4107SQU synthase EH233_08490 ENOG4107RCI amp-dependent synthetase and ligase EH233_08500 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EH233_08510 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) EH233_08520 ENOG4108HHA Transketolase EH233_08540 ENOG4105CHF Glutathione S-transferase EH233_08550 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EH233_08590 ENOG4105D7W serine acetyltransferase EH233_08595 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EH233_08605 ENOG4105X25 EH233_08640 ENOG4105VFU Rna-binding protein EH233_08645 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 EH233_08650 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EH233_08655 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EH233_08660 ENOG4107RNI Glucose 6-phosphate dehydrogenase effector OpcA EH233_08700 ENOG4108VHC Short-chain dehydrogenase reductase Sdr EH233_08745 ENOG4107WDG serine threonine protein kinase EH233_08775 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EH233_08810 ENOG4105EYH Exonuclease EH233_08815 ENOG4105BZU Histidine kinase EH233_08825 ENOG4108SHJ s-layer protein EH233_08830 ENOG4105BZU Histidine kinase EH233_08855 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EH233_08885 ENOG4105DZP Membrane-associated zinc metalloprotease EH233_08895 ENOG41082AF Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EH233_08905 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EH233_08920 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EH233_08960 ENOG4105C8S subunit m EH233_08970 ENOG4105K63 Thioredoxin EH233_08980 ENOG4105DUM transcriptional regulator, lysR family EH233_08990 ENOG4105C75 arginyL-tRNA synthetase EH233_08995 ENOG410667J hydrolase EH233_09000 ENOG4108JJB ABC transporter EH233_09010 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein EH233_09015 ENOG4108JJB ABC transporter EH233_09020 ENOG4108V4M Cobalt abc transporter EH233_09025 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) EH233_09030 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) EH233_09035 ENOG4105E3B Multicopper oxidase EH233_09055 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EH233_09065 ENOG4107QZB decarboxylase EH233_09070 ENOG4105K70 DNA-binding protein EH233_09190 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) EH233_09200 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EH233_09225 ENOG4105BZU Histidine kinase EH233_09245 ENOG4108J5G 6-phosphogluconate dehydrogenase EH233_09265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EH233_09275 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EH233_09295 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EH233_09305 ENOG4105J0C EH233_09315 ENOG4105CV8 reductase EH233_09340 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EH233_09360 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit EH233_09365 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding EH233_09370 ENOG4105C7W Xanthine dehydrogenase EH233_09375 ENOG4105XRQ Xanthine dehydrogenase accessory factor EH233_09380 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EH233_09385 ENOG4105FA0 parb-like partition protein EH233_09395 ENOG4107QJE Chromosome Partitioning Protein EH233_09415 ENOG4105D9P serine threonine protein kinase EH233_09420 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_09425 ENOG4105CF7 AraC family transcriptional regulator EH233_09440 ENOG4105EMU Dehydrogenase EH233_09445 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EH233_09460 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EH233_09510 ENOG4105CTK cobaltochelatase, cobn subunit EH233_09515 ENOG4105BZ1 (ABC) transporter EH233_09520 ENOG4105BZ1 (ABC) transporter EH233_09530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EH233_09535 ENOG4105BZU Histidine kinase EH233_09540 ENOG4105D52 delta-aminolevulinic acid dehydratase EH233_09545 ENOG4105C22 threonyL-tRNA synthetase EH233_09550 ENOG4105CKI cobalamin synthesis protein EH233_09555 ENOG4105EUJ GTP cyclohydrolase i EH233_09565 ENOG4105D3Q Sugar transferase EH233_09570 ENOG4105C1J atp-dependent rna helicase EH233_09580 ENOG4105BZU Histidine kinase EH233_09585 ENOG4105BZ1 (ABC) transporter EH233_09595 ENOG4105CMR udp-glucose 4-epimerase EH233_09605 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EH233_09610 ENOG4107VAM peptidase, m28 EH233_09620 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EH233_09630 ENOG4107QRG dna polymerase iii EH233_09645 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EH233_09650 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EH233_09655 ENOG4105CIA precorrin-4 C(11)-methyltransferase EH233_09665 ENOG4108YZN class I peptide chain release factor EH233_09675 ENOG41080ZE Adenylate cyclase EH233_09690 ENOG4105K56 Transcriptional regulator EH233_09700 ENOG4108KQJ Type 11 methyltransferase EH233_09720 ENOG4105JZI cytochrome P450 EH233_09725 ENOG4108X7A Terpene synthase metal-binding domain-containing protein EH233_09740 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EH233_09760 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EH233_09780 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EH233_09795 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EH233_09800 ENOG4107WDG serine threonine protein kinase EH233_09805 ENOG4107Y82 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EH233_09830 ENOG4108VPT UPF0234 protein EH233_09835 ENOG4105CYM Glutathione S-transferase EH233_09860 ENOG4107S5T Carbohydrate kinase EH233_09865 ENOG4105RD7 BadF BadG BcrA BcrD EH233_09880 ENOG41063FQ CsbD-like protein EH233_09915 ENOG4108UHU Aldolase EH233_09930 ENOG4105VGQ Photosystem I subunit X EH233_09935 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EH233_09940 ENOG4105CAU Arsenical resistance protein, ArsH EH233_09950 ENOG4105ETX regulatoR EH233_09955 ENOG4105GR3 Histidine kinase EH233_09965 ENOG4108PWY Carbohydrate-selective porin OprB EH233_09975 ENOG4105BZ1 (ABC) transporter EH233_09980 ENOG4105E2K Glycosyl transferase (Group 1 EH233_09985 ENOG4107T8Q Glycosyl transferase (Group 1 EH233_10000 ENOG4105CJW magnesium transporter EH233_10010 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EH233_10030 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EH233_10035 ENOG4105F4R Transcriptional regulator mode EH233_10050 ENOG4105BZU Histidine kinase EH233_10055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_10080 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EH233_10125 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 EH233_10130 ENOG4105MN0 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 EH233_10140 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EH233_10165 ENOG4108JJA ABC, transporter EH233_10200 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EH233_10215 ENOG4105K64 Glycosyl transferase, family 2 EH233_10245 ENOG4107RIQ Sulfate adenylate transferase EH233_10255 ENOG4105CVM Molybdenum cofactor synthesis domain protein EH233_10315 ENOG4105CHR reductase EH233_10335 ENOG4108IJ8 ABC transporter EH233_10340 ENOG4105E90 ABC transporter EH233_10360 ENOG4105BZU Histidine kinase EH233_10380 ENOG4105CE4 GlcNAc 6-P deacetylase EH233_10395 ENOG4107RAJ Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EH233_10405 ENOG4105D4Y metalloprotease EH233_10415 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EH233_10420 ENOG4105BZU Histidine kinase EH233_10430 ENOG4105C26 Dehydrogenase EH233_10440 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EH233_10445 ENOG4106Q05 Rod-core linker protein required for attachment of phycocyanin to allophycocyanin in cores of phycobilisomes (By similarity) EH233_10455 ENOG4106BTU phycobilisome rod-core linker polypeptide EH233_10460 ENOG4106BTU phycobilisome rod-core linker polypeptide EH233_10465 ENOG4108V9J phycocyanobilin lyase EH233_10470 ENOG41078GB pbs lyase EH233_10480 ENOG4108MZQ phycobilisome linker polypeptide EH233_10485 ENOG4108SDR phycocyanin, alpha subunit EH233_10490 ENOG4105D6V phycocyanin beta subunit EH233_10495 ENOG4106TM1 PBS lyase HEAT-like repeat EH233_10500 ENOG41078GB pbs lyase EH233_10515 ENOG4106KF1 Phycobilisome protein EH233_10550 ENOG4105D7K pfkb domain protein EH233_10560 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) EH233_10565 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EH233_10575 ENOG4105DXN mazG family EH233_10615 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EH233_10640 ENOG4105CQR helicase EH233_10650 ENOG41080W8 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EH233_10665 ENOG4107U45 Cobalt transport protein EH233_10670 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EH233_10720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EH233_10750 ENOG4105DFS Conserved Protein EH233_10785 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EH233_10790 ENOG41066GP CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) EH233_10810 ENOG4105D5K Hemolysin activator protein EH233_10850 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EH233_10900 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EH233_10915 ENOG4107YZX Universal stress protein EH233_10920 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EH233_10925 ENOG41084H8 Binds directly to 16S ribosomal RNA (By similarity) EH233_10940 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EH233_10945 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EH233_10950 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EH233_10970 ENOG4105CXI aluminum resistance protein EH233_10975 ENOG4106I2R Coenzyme F420 hydrogenase dehydrogenase, beta EH233_10985 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) EH233_10990 ENOG4105Q36 FHA domain containing protein EH233_11010 ENOG4105CFH Aspartokinase EH233_11035 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EH233_11040 ENOG4107QIK phosphoribosylformylglycinamidine synthase EH233_11045 ENOG4108S1Y allophycocyanin alpha-B chain EH233_11050 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EH233_11070 ENOG4105C5S asparaginyl-tRNA synthetase EH233_11085 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EH233_11090 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EH233_11115 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EH233_11120 ENOG4108YZ9 Urea amidohydrolase subunit gamma EH233_11125 ENOG4105KI2 Urea amidohydrolase subunit beta EH233_11135 ENOG4105CQM Urea amidohydrolase subunit alpha EH233_11145 ENOG4105BZU Histidine kinase EH233_11150 ENOG4105C26 Dehydrogenase EH233_11160 ENOG41068G9 50S ribosomal protein L32 EH233_11180 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EH233_11195 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EH233_11205 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EH233_11210 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EH233_11215 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EH233_11255 ENOG4105D64 Mechanosensitive ion channel EH233_11260 ENOG4105D64 Mechanosensitive ion channel EH233_11305 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EH233_11320 ENOG4105E67 Catalyzes the four-electron reduction of biliverdin IX- alpha (2-electron reduction at both the A and D rings) EH233_11335 ENOG4105E0Y RtcB Protein EH233_11340 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EH233_11365 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) EH233_11370 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EH233_11375 ENOG4107TS3 membrane protein, TerC EH233_11390 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EH233_11395 ENOG4105W8H transhydrogenase (subunit alpha EH233_11400 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EH233_11415 ENOG41082ZZ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EH233_11425 ENOG4107RIX inner membrane protein translocase component YidC EH233_11460 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EH233_11465 ENOG4108R6B Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EH233_11475 ENOG4105C0K Gdp-mannose 4,6-dehydratase EH233_11480 ENOG4105JNK Glycosyl transferase (Group 1 EH233_11490 ENOG41084A0 50s ribosomal protein L35 EH233_11495 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EH233_11520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_11530 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EH233_11560 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EH233_11565 ENOG4107QN2 dihydrolipoyl dehydrogenase EH233_11590 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EH233_11595 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) EH233_11600 ENOG4105BZU Histidine kinase EH233_11635 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EH233_11650 ENOG4107XW6 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EH233_11660 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) EH233_11670 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EH233_11690 ENOG4108Z6M essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA B D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin cytochrome c6- ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn EH233_11720 ENOG4108E1C hydrolase EH233_11730 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EH233_11765 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_11800 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EH233_11805 ENOG4105EEX Two component transcriptional regulator (Winged helix family EH233_11820 ENOG4105CPU Monooxygenase EH233_11825 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EH233_11840 ENOG4105WN2 Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase (By similarity) EH233_11845 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EH233_11850 ENOG4105X1F electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) EH233_11855 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EH233_11865 ENOG4105J3Z Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EH233_11875 ENOG4105CHM Aminotransferase EH233_11890 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EH233_11900 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EH233_11905 ENOG4108XAD Protein of unknown function (DUF1997) EH233_11915 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EH233_11920 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EH233_11925 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EH233_11930 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EH233_11935 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EH233_11940 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EH233_11950 ENOG4105CJT Mannose-1-phosphate guanylyltransferase EH233_11965 ENOG4108ZJ4 polysaccharide deacetylase EH233_11975 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) EH233_11990 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EH233_12020 ENOG4108HMX isocitrate dehydrogenase (NADP) EH233_12030 ENOG4108IJ9 (ABC) transporter EH233_12085 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EH233_12110 ENOG4105MYT Heat shock protein EH233_12145 ENOG4105CZN Potassium uptake protein EH233_12150 ENOG4107ZYR domain protein EH233_12160 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EH233_12170 ENOG41083KH UPF0102 protein EH233_12185 ENOG4108ZJ4 polysaccharide deacetylase EH233_12245 ENOG4108JPZ Monovalent cation H antiporter subunit D EH233_12250 ENOG4105MKQ Monovalent cation H antiporter subunit C EH233_12260 ENOG4107YD0 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EH233_12265 ENOG4105BZU Histidine kinase EH233_12270 ENOG4107Z5C methylesterase EH233_12275 ENOG4105BZU Histidine kinase EH233_12280 ENOG4105CHR reductase EH233_12300 ENOG41066AK Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) EH233_12305 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EH233_12310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EH233_12335 ENOG4105RYY domain protein EH233_12345 ENOG4105CSR polyphosphate kinase 2 EH233_12350 ENOG4105VFU Rna-binding protein EH233_12370 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EH233_12415 ENOG4108UYE Lactoylglutathione lyase EH233_12420 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EH233_12435 ENOG4107S2Z UPF0761 membrane protein EH233_12455 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EH233_12465 ENOG4108VIA integral membrane protein EH233_12480 ENOG4105E2X shikimate dehydrogenase EH233_12510 ENOG4105CPC Aldo Keto reductase EH233_12530 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EH233_12565 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EH233_12575 ENOG4105BZU Histidine kinase EH233_12580 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EH233_12590 ENOG4105CKD glutathione-regulated potassium-efflux system protein EH233_12595 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EH233_12615 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EH233_12625 ENOG4108HMN Caspase domain EH233_12650 ENOG4105CN1 protease EH233_12655 ENOG4107R8N Glycosyl transferase, family 2 EH233_12670 ENOG4105GHY electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) EH233_12725 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EH233_12730 ENOG4105BZU Histidine kinase EH233_12735 ENOG410841Q phosphoesterase PA-phosphatase related protein EH233_12740 ENOG4105CD8 aminopeptidase N EH233_12780 ENOG4107EF8 Glycosyl transferase (Group 1 EH233_12785 ENOG4105BZ1 (ABC) transporter EH233_12800 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EH233_12805 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EH233_12810 ENOG4105CDU Replicative dna helicase EH233_12810 ENOG4105CDU Replicative dna helicase EH233_12830 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EH233_12845 ENOG4105DDG Cyanophycinase EH233_12880 ENOG4105CA3 membrane-bound lytic murein transglycosylase EH233_12960 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EH233_12975 ENOG41083MR nifu domain-containing protein EH233_12980 ENOG4105BZU Histidine kinase EH233_13020 ENOG4105D9U N-acetyltransferase EH233_13035 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR EH233_13045 ENOG4105C5H ABC transporter EH233_13060 ENOG4105BZ1 (ABC) transporter EH233_13070 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) EH233_13100 ENOG4105BZU Histidine kinase EH233_13115 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EH233_13120 ENOG4108UXN response regulator EH233_13145 ENOG4105EVB acetyltransferase EH233_13175 ENOG4105C31 Tryptophanyl-tRNA synthetase EH233_13190 ENOG4108V5V Serine Threonine protein kinase EH233_13195 ENOG4108V5V Serine Threonine protein kinase EH233_13205 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EH233_13230 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EH233_13235 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EH233_13260 ENOG4105CJW magnesium transporter EH233_13280 ENOG4105BZU Histidine kinase EH233_13285 ENOG4105CTK cobaltochelatase, cobn subunit EH233_13295 ENOG4107XWZ ferric uptake regulator EH233_13300 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EH233_13305 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EH233_13310 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EH233_13335 ENOG4107XZC Restriction modification system DNA (Specificity EH233_13340 ENOG4105CB5 ATP-dependent DNA helicase recG EH233_13345 ENOG4105DZR Type I site-specific deoxyribonuclease EH233_13360 ENOG4105D9P serine threonine protein kinase EH233_13380 ENOG4105BZU Histidine kinase EH233_13390 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EH233_13410 ENOG4105D5K Hemolysin activator protein EH233_13430 ENOG4107T8Q Glycosyl transferase (Group 1 EH233_13435 ENOG4105FTV AraC Family Transcriptional Regulator EH233_13515 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_13540 ENOG4108ISE 4Fe-4S ferredoxin, iron-sulfur binding EH233_13575 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EH233_13580 ENOG4105K63 Thioredoxin EH233_13605 ENOG4105C5I Dehydrogenase EH233_13610 ENOG4107YJ4 chain length determinant protein EH233_13630 ENOG41082QS Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EH233_13645 ENOG4105DHP deoxycytidine triphosphate deaminase EH233_13655 ENOG4106QP8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EH233_13660 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EH233_13670 ENOG4105DHJ ABC, transporter EH233_13680 ENOG4105BZU Histidine kinase EH233_13695 ENOG4105N7N Pentapeptide repeat-containing protein EH233_13700 ENOG4108KGH TRANSCRIPTIONal EH233_13715 ENOG4105CJ1 ABC, transporter EH233_13725 ENOG4105D9P serine threonine protein kinase EH233_13765 ENOG4105C8M UPF0272 protein EH233_13770 ENOG4107RTD sua5 ycio yrdc ywlc family protein EH233_13785 ENOG4105C9U ATP-dependent DNA helicase RecQ EH233_13810 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) EH233_13820 ENOG4105KHC sulfurtransferase EH233_13825 ENOG4105DFS Conserved Protein EH233_13830 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EH233_13840 ENOG4105DX0 Hemolysin A EH233_13845 ENOG4108UMY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EH233_13850 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EH233_13855 ENOG4105E2Z phosphate ABC transporter (Permease EH233_13860 ENOG4105C8U phosphate abc transporter EH233_13865 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) EH233_13870 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EH233_13875 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_13950 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EH233_13960 ENOG4108I0Q anthranilate phosphoribosyltransferase EH233_13965 ENOG4105F04 LysR family Transcriptional regulator EH233_13970 ENOG4108PWY Carbohydrate-selective porin OprB EH233_13990 ENOG4105I5W Transporter EH233_14005 ENOG4105D7T ABC transporter EH233_14010 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EH233_14035 ENOG4108P5B Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) EH233_14055 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) EH233_14065 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EH233_14070 ENOG4105CQB FAD linked oxidase domain protein EH233_14120 ENOG4107RAQ aminopeptidase EH233_14150 ENOG4105BZU Histidine kinase EH233_14185 ENOG4105CMS peptidase U62, modulator of DNA gyrase EH233_14195 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EH233_14200 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EH233_14205 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EH233_14210 ENOG4105N7N Pentapeptide repeat-containing protein EH233_14235 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EH233_14250 ENOG4108UXN response regulator EH233_14265 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EH233_14270 ENOG4108UQX Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II (By similarity) EH233_14275 ENOG4105H0N Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I EH233_14320 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EH233_14350 ENOG4105CEY Amp-dependent synthetase and ligase EH233_14360 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EH233_14365 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EH233_14375 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EH233_14390 ENOG4105C3J Cysteine desulfurase EH233_14400 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EH233_14405 ENOG4105CFI type iii restriction protein res subunit EH233_14510 ENOG4105CDU Replicative dna helicase EH233_14670 ENOG4105CNF WD-40 repeat protein EH233_14690 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_14775 ENOG4105DR5 peptidase EH233_14890 ENOG4105C0D helicase EH233_14965 ENOG4105DR5 peptidase EH233_14975 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EH233_14985 ENOG4105K63 Thioredoxin EH233_14990 ENOG4105NAN IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EH233_15005 ENOG4105CJ1 ABC, transporter EH233_15020 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EH233_15030 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EH233_15050 ENOG4105CVN desaturase EH233_15085 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP EH233_15090 ENOG410715G filament integrity protein EH233_15095 ENOG4105RRH EH233_15115 ENOG4108JPW Aminotransferase EH233_15135 ENOG4107WDG serine threonine protein kinase EH233_15160 ENOG4105BZU Histidine kinase EH233_15170 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EH233_15210 ENOG4108JA1 polyketide synthase EH233_15225 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EH233_15275 ENOG4107S1Q Phosphatase EH233_15320 ENOG4105BZU Histidine kinase EH233_15360 ENOG4105KHC sulfurtransferase EH233_15365 ENOG41066VF YeeE YedE family protein EH233_15370 ENOG4108IQK o-acetylhomoserine EH233_15375 ENOG4107QT6 homoserine O-acetyltransferase EH233_15440 ENOG4105DGI Alkaline phosphatase EH233_15470 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_15480 ENOG4105E2Y ABC, transporter EH233_15485 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EH233_15490 ENOG4108PWY Carbohydrate-selective porin OprB EH233_15495 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EH233_15500 ENOG4105CPU Monooxygenase EH233_15515 ENOG4105CPC Aldo Keto reductase EH233_15520 ENOG4105GVF (ABC) transporter EH233_15530 ENOG4107UWC ABC, transporter EH233_15555 ENOG4108DBC nitroreductase EH233_15560 ENOG4105GVF (ABC) transporter EH233_15565 ENOG4105C28 cystathionine EH233_15605 ENOG4105C8S subunit m EH233_15625 ENOG4105CJN penicillin-binding protein EH233_15630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EH233_15635 ENOG4107RUE extracellular solute-binding protein family 1 EH233_15640 ENOG4105F38 ABC transporter, permease EH233_15655 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EH233_15660 ENOG410823V Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EH233_15680 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EH233_15700 ENOG4108UV1 cellular component movement EH233_15710 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related EH233_15730 ENOG4107STW synthase EH233_15735 ENOG4105DUM transcriptional regulator, lysR family EH233_15755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EH233_15780 ENOG4105CIK Amidinotransferase EH233_15805 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EH233_15810 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EH233_15820 ENOG4105DKQ ROK family EH233_15830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EH233_15845 ENOG4105CUT histidyl-tRNA synthetase EH233_15850 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EH233_15880 ENOG4108KQI regulatory protein luxr EH233_15890 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EH233_15895 ENOG4105M6F mutator MutT protein EH233_15905 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EH233_15910 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EH233_15915 ENOG4108NWW ferritin dps family protein EH233_15925 ENOG4105E0R Deoxyhypusine synthase EH233_15935 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EH233_15950 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EH233_15955 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EH233_15965 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EH233_15975 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EH233_16010 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EH233_16025 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EH233_16040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_16045 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EH233_16060 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EH233_16065 ENOG4105ETX regulatoR EH233_16085 ENOG4105DK0 Indole-3-glycerol phosphate synthase EH233_16140 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_16150 ENOG4105BZU Histidine kinase EH233_16155 ENOG4105BZU Histidine kinase EH233_16160 ENOG4105BZU Histidine kinase EH233_16170 ENOG4105BZU Histidine kinase EH233_16180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_16185 ENOG41082AN stage II sporulation protein EH233_16190 ENOG4107QJZ Glycosyl transferase, family 2 EH233_16210 ENOG4108W6C Dehydrogenase EH233_16220 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EH233_16235 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EH233_16255 ENOG4105EWK phytoene EH233_16265 ENOG41088WE This is one of the two reaction center proteins of photosystem II EH233_16270 ENOG4105EA8 2-Nitropropane dioxygenase EH233_16280 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EH233_16300 ENOG4105EIE fructose-bisphosphate aldolase EH233_16310 ENOG4107WDG serine threonine protein kinase EH233_16315 ENOG4107S1Q Phosphatase EH233_16320 ENOG4105DXX methyltransferase EH233_16330 ENOG4108IG5 Transcriptional regulator EH233_16335 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II EH233_16345 ENOG4105C6E dna polymerase iii EH233_16370 ENOG4105D7V transposase EH233_16425 ENOG4108I5C dEAD DEAH box helicase EH233_16435 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EH233_16645 ENOG4105E6M Sulphatase-modifying factor protein EH233_16670 ENOG4105VDM plasmid maintenance system antidote protein, xre family EH233_16715 ENOG4105BZU Histidine kinase EH233_16725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EH233_16730 ENOG4106YN8 Prenyltransferase EH233_16735 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EH233_16745 ENOG4108IAJ Nad-dependent epimerase dehydratase EH233_16790 ENOG4105D1H recombination factor protein RarA EH233_16825 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EH233_16835 ENOG4105CHH sulfate transporter EH233_16855 ENOG4105D7V transposase EH233_16900 ENOG4106H3A restriction EH233_17000 ENOG4105CFI type iii restriction protein res subunit EH233_17005 ENOG4107RSM transcriptional regulator EH233_17015 ENOG4105DGI Alkaline phosphatase EH233_17020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EH233_17035 ENOG4105U3E Transcriptional regulator EH233_17055 ENOG4105DC8 reductase EH233_17060 ENOG4105IPS esterase EH233_17065 ENOG4105CIH Imidazole acetol-phosphate transaminase EH233_17140 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 EH233_17150 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EH233_17175 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EH233_17195 ENOG4105CND Glycosyl transferase, family 2 EH233_17200 ENOG4105KK4 UPF0060 membrane protein EH233_17220 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EH233_17235 ENOG41075H3 AraC family transcriptional regulator EH233_17255 ENOG4108PWY Carbohydrate-selective porin OprB EH233_17300 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) EH233_17310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EH233_17325 ENOG4105E0K tonB-dependent siderophore receptor EH233_17360 ENOG4105EV8 ectoine hydroxylase EH233_17410 ENOG4107CUI carotenoid binding protein EH233_17420 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EH233_17430 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EH233_17435 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EH233_17440 ENOG4105ES5 Histidine kinase EH233_17450 ENOG4105BZU Histidine kinase EH233_17480 ENOG4108KK4 3-dehydroquinate synthase EH233_17485 ENOG4105C59 p-type ATPase EH233_17490 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EH233_17500 ENOG41081F0 Precorrin-8x methylmutase EH233_17505 ENOG4105DSF transport protein EH233_17520 ENOG4105BZU Histidine kinase EH233_17525 ENOG4105KAN Probably a ribosomal protein or a ribosome-associated protein (By similarity) EH233_17535 ENOG4105BZU Histidine kinase EH233_17570 ENOG4106WTF Glycosyl transferase, family 2 EH233_17575 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF EH233_17660 ENOG4105VMP Transcriptional regulator EH233_17690 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EH233_17705 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EH233_17710 ENOG41084GG 50S ribosomal protein L33 EH233_17730 ENOG4105CFG Acts as a chaperone (By similarity) EH233_17750 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EH233_17765 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EH233_17780 ENOG41084IE Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EH233_17785 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EH233_17805 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EH233_17815 ENOG4107S8C mandelate racemase muconate lactonizing EH233_17835 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EH233_17840 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EH233_17850 ENOG4105DWF phosphomethylpyrimidine kinase EH233_17890 ENOG4105BZU Histidine kinase EH233_17910 ENOG4105C9X ppx gppa phosphatase EH233_17930 ENOG4105C7K acetolactate synthase EH233_17940 ENOG4105D9P serine threonine protein kinase EH233_17945 ENOG4108JUA Transcriptional regulator EH233_17960 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EH233_17980 ENOG4105WXN Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EH233_17995 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EH233_18005 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EH233_18045 ENOG4105BZU Histidine kinase EH233_18050 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_18055 ENOG4108Z6B deaminase EH233_18060 ENOG4105EYW Ion transport protein EH233_18070 ENOG4105EWK phytoene EH233_18100 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EH233_18135 ENOG4108JQ6 ABC transporter EH233_18160 ENOG4108IJ9 (ABC) transporter EH233_18175 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EH233_18180 ENOG41085RW This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EH233_18185 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) EH233_18195 ENOG4105GVF (ABC) transporter EH233_18200 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EH233_18210 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EH233_18230 ENOG4108PWY Carbohydrate-selective porin OprB EH233_18235 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein EH233_18260 ENOG4108UR2 Nitrogen fixation protein NifX EH233_18265 ENOG4105D0B Nitrogenase protein alpha chain EH233_18280 ENOG4105C4M (Ubiquinol oxidase) subunit I EH233_18285 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EH233_18310 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family EH233_18315 ENOG4107S73 homocitrate synthase EH233_18330 ENOG4108JJB ABC transporter EH233_18335 ENOG4105XEA Tetr family transcriptional regulator EH233_18345 ENOG4108DBC nitroreductase EH233_18380 ENOG4105D0B Nitrogenase protein alpha chain EH233_18385 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain EH233_18390 ENOG4105D0B Nitrogenase protein alpha chain EH233_18405 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) EH233_18410 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EH233_18430 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EH233_18450 ENOG4105CJN penicillin-binding protein EH233_18475 ENOG4105C3G gtp-binding protein EH233_18495 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EH233_18500 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EH233_18505 ENOG4105BZU Histidine kinase EH233_18520 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) EH233_18525 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EH233_18535 ENOG4105C3M thioredoxin reductase EH233_18550 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) EH233_18560 ENOG4105EPW hflc protein EH233_18565 ENOG4105VFU Rna-binding protein EH233_18570 ENOG410848W 30S ribosomal protein S21 EH233_18575 ENOG4105XUP Phage derived protein Gp49-like (DUF891) EH233_18585 ENOG4105F8J Adenylate Guanylate cyclase EH233_18595 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EH233_18605 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase EH233_18615 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EH233_18630 ENOG4107QIZ NADH dehydrogenase EH233_18645 ENOG4108IEH NADH dehydrogenase subunit g EH233_18655 ENOG4105D6H One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity) EH233_18660 ENOG4105VUV UPF0367 protein EH233_18665 ENOG4108JJB ABC transporter EH233_18670 ENOG4105M0M Tetracycline resistance protein EH233_18695 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EH233_18700 ENOG4107WDG serine threonine protein kinase EH233_18705 ENOG4105CQB FAD linked oxidase domain protein EH233_18715 ENOG4105F32 YngK protein EH233_18745 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EH233_18770 ENOG4105DRS transport system, permease EH233_18775 ENOG410612X Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane EH233_18785 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EH233_18795 ENOG4105EUJ GTP cyclohydrolase i EH233_18800 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EH233_18805 ENOG4105VGQ Photosystem I subunit X EH233_18810 ENOG4106INZ Photosystem I reaction center subunit EH233_18820 ENOG4108Y85 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) EH233_18835 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EH233_18850 ENOG4108SGK Tetr family transcriptional regulator EH233_18855 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EH233_18875 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EH233_18880 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EH233_18885 ENOG4107Z3D 50S ribosomal protein l10 EH233_18890 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EH233_18900 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EH233_18910 ENOG4105EMU Dehydrogenase EH233_18975 ENOG41068BY Low temperature-induced protein EH233_18980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EH233_19000 ENOG4108RMU ferritin dps family protein EH233_19005 ENOG4105J0C EH233_19010 ENOG41081F0 Precorrin-8x methylmutase EH233_19015 ENOG4105DVK Precorrin-2 c20-methyltransferase EH233_19030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EH233_19035 ENOG4105D0S secretion protein (HlyD EH233_19040 ENOG4105C19 ABC transporter EH233_19045 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EH233_19060 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) EH233_19065 ENOG4105IJJ transcriptional regulator, crp fnr family EH233_19070 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EH233_19100 ENOG4108NAW Type II site-specific deoxyribonuclease EH233_19115 ENOG4108SHJ s-layer protein EH233_19140 ENOG4108IQE Amp-dependent synthetase and ligase EH233_19155 ENOG4105BZU Histidine kinase EH233_19180 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EH233_19215 ENOG4105BZU Histidine kinase EH233_19260 ENOG4107RSS Hydrogenase accessory protein HypB EH233_19265 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) EH233_19270 ENOG4105C45 hydrogenase expression formation protein (HypE) EH233_19280 ENOG4105CQS hydrogenase expression formation protein HypD EH233_19285 ENOG41082MF Hydrogenase assembly chaperone hypC hupF EH233_19290 ENOG4105C8H hydrogenase maturation protein Hypf EH233_19325 ENOG4105DPX Hydrogenase, large subunit EH233_19345 ENOG4108Z66 YbaK ebsC protein EH233_19350 ENOG4105C6Y Udp-glucose 6-dehydrogenase EH233_19355 ENOG4108IAJ Nad-dependent epimerase dehydratase EH233_19375 ENOG4105CNI cell division protein FtsW EH233_19390 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EH233_19400 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) EH233_19405 ENOG4105D7V transposase EH233_19410 ENOG4108R9R May be involved in photosynthetic membrane biogenesis (By similarity) EH233_19435 ENOG4105BZ1 (ABC) transporter EH233_19460 ENOG4105CFP Peptidase U32 EH233_19465 ENOG4105CFG Acts as a chaperone (By similarity) EH233_19485 ENOG4108RXX maleylacetoacetate isomerase EH233_19500 ENOG4105DSE periplasmic solute binding protein EH233_19515 ENOG4105CKI cobalamin synthesis protein EH233_19530 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EH233_19550 ENOG4107SGM protein serine threonine phosphatase EH233_19560 ENOG4107Y1F Involved in the transcription termination process (By similarity) EH233_19570 ENOG4106WTF Glycosyl transferase, family 2 EH233_19605 ENOG4105X0D Fimbrial protein EH233_19625 ENOG41060D5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EH233_19630 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EH233_19635 ENOG4105CKI cobalamin synthesis protein EH233_19640 ENOG4105C8N cysteinyl-tRNA synthetase EH233_19650 ENOG4105CMS peptidase U62, modulator of DNA gyrase EH233_19655 ENOG4105BZU Histidine kinase EH233_19660 ENOG41082AN stage II sporulation protein EH233_19665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EH233_19690 ENOG4105MSA Photosystem II reaction center W protein EH233_19700 ENOG4105C8Y Acetylornithine aminotransferase EH233_19710 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EH233_19720 ENOG4105FDP GntR family transcriptional regulator EH233_19725 ENOG4105F8J Adenylate Guanylate cyclase EH233_19755 ENOG4105DGI Alkaline phosphatase EH233_19775 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EH233_19785 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EH233_19820 ENOG4105BZU Histidine kinase EH233_19845 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) EH233_19880 ENOG4105CPK Glycosyl transferase (Group 1 EH233_19900 ENOG4107YJ4 chain length determinant protein EH233_19915 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EH233_19940 ENOG4107VQD May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) EH233_19945 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EH233_19980 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EH233_20015 ENOG4108302 MgtC SapB transporter EH233_20060 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EH233_20075 ENOG4105VUN Transcriptional regulator EH233_20090 ENOG4105CDY transcriptional regulatory protein EH233_20140 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EH233_20145 ENOG41068WN EH233_20155 ENOG4108S5W Seems to be required for the assembly of the photosystem I complex (By similarity) EH233_20175 ENOG4105E5J UV damage endonuclease EH233_20180 ENOG4105CFG Acts as a chaperone (By similarity) EH233_20225 ENOG4108V3E phosphoribosylglycinamide formyltransferase EH233_20260 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EH233_20275 ENOG4105CAS nag kinase EH233_20280 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EH233_20310 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EH233_20320 ENOG4105C7Z Conserved Protein EH233_20345 ENOG410801B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EH233_20360 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EH233_20370 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EH233_20375 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EH233_20435 ENOG4105DC1 bifunctional purine biosynthesis protein purh EH233_20440 ENOG4105BZU Histidine kinase EH233_20450 ENOG4105WEF catalase EH233_20455 ENOG4105Y3U Transglycosylase-associated protein EH233_20460 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EH233_20465 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) EH233_20510 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EH233_20520 ENOG41072GX Peptidase M22 Glycoprotease EH233_20525 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EH233_20550 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EH233_20560 ENOG4108IJ0 Aspartate ammonia-lyase EH233_20570 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase EH233_20585 ENOG4105C75 arginyL-tRNA synthetase EH233_20625 ENOG4105CPK Glycosyl transferase (Group 1 EH233_20645 ENOG4105E2K Glycosyl transferase (Group 1 EH233_20690 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) EH233_20700 ENOG4105D9P serine threonine protein kinase EH233_20705 ENOG4105VFU Rna-binding protein EH233_20715 ENOG4105CD2 stage iii sporulation protein aa EH233_20725 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_20730 ENOG4105BZU Histidine kinase EH233_20745 ENOG4105CD3 dihydroorotase EH233_20755 ENOG4105K8N protein family UPF0079, ATPase EH233_20765 ENOG4105CHW UPF0052 protein EH233_20770 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EH233_20790 ENOG4107XGZ Hydrolase EH233_20795 ENOG4105E6M Sulphatase-modifying factor protein EH233_20800 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) EH233_20810 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EH233_20815 ENOG4105CPC Aldo Keto reductase EH233_20840 ENOG4107T8P acyl-Coa dehydrogenase EH233_20845 ENOG4105E1J oxidoreductase EH233_20875 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EH233_20890 ENOG4108SHN Glycosyl transferase, family 2 EH233_20895 ENOG4105BZ1 (ABC) transporter EH233_20900 ENOG4105D3Q Sugar transferase EH233_20905 ENOG4107YJ4 chain length determinant protein EH233_20910 ENOG4108TJN glycosyl transferase group 1 EH233_20920 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EH233_20945 ENOG4105CMR udp-glucose 4-epimerase EH233_20950 ENOG4105D5U fad dependent oxidoreductase EH233_20955 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EH233_20970 ENOG4108M24 von Willebrand factor, type A EH233_20975 ENOG4108UNF response regulator EH233_21035 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EH233_21040 ENOG4105KVH Transcriptional regulator EH233_21060 ENOG4107VEG TrkA-N domain protein EH233_21100 ENOG4105CE1 Ferrous iron transport protein b EH233_21125 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EH233_21165 ENOG4105C4W S-formylglutathione hydrolase EH233_21175 ENOG4107QPD alcohol dehydrogenase EH233_21180 ENOG4105JKW Valine--pyruvate aminotransferase EH233_21200 ENOG4105BZU Histidine kinase EH233_21245 ENOG4108PWY Carbohydrate-selective porin OprB EH233_21265 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EH233_21275 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EH233_21280 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EH233_21285 ENOG4105ES5 Histidine kinase EH233_21290 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_21305 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) EH233_21315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EH233_21330 ENOG4105E0K tonB-dependent siderophore receptor EH233_21335 ENOG4105E0K tonB-dependent siderophore receptor EH233_21355 ENOG4105F32 YngK protein EH233_21365 ENOG4108DIG cyanophycin synthetase EH233_21390 ENOG4108RVA ribokinase EH233_21415 ENOG4105C9M aspartyl-trna synthetase EH233_21435 ENOG4108IJ6 ABC transporter EH233_21440 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EH233_21455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EH233_21500 ENOG4105E0A ABC, transporter EH233_21505 ENOG4105J76 Periplasmic binding protein EH233_21510 ENOG4105S6R Iron-hydroxamate transporter permease subunit EH233_21530 ENOG4105C72 UPF0176 protein EH233_21535 ENOG4107Z12 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EH233_21540 ENOG4105D9N nucleoside EH233_21550 ENOG4108E2B had-superfamily hydrolase, subfamily iib EH233_21555 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EH233_21560 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EH233_21570 ENOG4105CNF WD-40 repeat protein EH233_21595 ENOG410834F Transcriptional regulator EH233_21625 ENOG4108ZF3 Phosphatase EH233_21660 ENOG4107WDG serine threonine protein kinase EH233_21730 ENOG4105FA0 parb-like partition protein EH233_21735 ENOG4107QJE Chromosome Partitioning Protein EH233_21770 ENOG4105CDU Replicative dna helicase EH233_21770 ENOG4105CDU Replicative dna helicase EH233_21815 ENOG4105BZU Histidine kinase EH233_21855 ENOG4108ZGN Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity) EH233_21860 ENOG4105CZX twitching motility protein EH233_21870 ENOG4107QRT dEAD DEAH box helicase EH233_21895 ENOG4108IAJ Nad-dependent epimerase dehydratase EH233_21905 ENOG4105CVJ phosphoglycerate mutase EH233_21915 ENOG41086BQ Protein CrcB homolog EH233_21920 ENOG41086B8 CoB-CoM heterodisulfide reductase EH233_21925 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EH233_21940 ENOG4105CV1 Transketolase (EC 2.2.1.1) EH233_21975 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family EH233_22020 ENOG4105D7V transposase EH233_22035 ENOG4105C0D helicase EH233_22035 ENOG4105C0D helicase EH233_22170 ENOG4108IV0 ABC, transporter EH233_22175 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EH233_22215 ENOG4108TNP EH233_22230 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EH233_22255 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EH233_22270 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EH233_22280 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EH233_22285 ENOG4107QRI Phosphoketolase EH233_22290 ENOG4108N5B 2-phosphosulfolactate phosphatase EH233_22300 ENOG4105D0M Protease HtpX homolog EH233_22310 ENOG4108JA5 May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity) EH233_22365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EH233_22375 ENOG4105GR3 Histidine kinase EH233_22380 ENOG4105BZU Histidine kinase EH233_22410 ENOG4105ZDA EH233_22435 ENOG4108IND Tetr family transcriptional regulator EH233_22450 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EH233_22460 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EH233_22485 ENOG4105C8Q Methyl-accepting chemotaxis EH233_22510 ENOG4107UAN Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EH233_22520 ENOG4105CRE cytochrome C EH233_22540 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EH233_22550 ENOG4106AG1 Involved in the binding and or turnover of quinones at the Q(B) site of Photosystem II (By similarity) EH233_22575 ENOG4105E33 succinate dehydrogenase EH233_22590 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EH233_22625 ENOG4105K64 Glycosyl transferase, family 2 EH233_22685 ENOG4107S78 Band 7 protein EH233_22700 ENOG4105EYM Major Facilitator superfamily EH233_22720 ENOG4105CJT Mannose-1-phosphate guanylyltransferase EH233_22745 ENOG4105ERG peptidase m48, ste24p EH233_22760 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EH233_22765 ENOG4108FN7 Aldo keto reductase EH233_22795 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EH233_22805 ENOG41083EU 50s ribosomal protein l28 EH233_22815 ENOG4105IJJ transcriptional regulator, crp fnr family EH233_22820 ENOG4105CN1 protease EH233_22825 ENOG4108TCG allophycocyanin beta subunit EH233_22830 ENOG4105C5F glutamine synthetase EH233_22840 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EH233_22865 ENOG4105CPQ Dehydrogenase EH233_22905 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EH233_22920 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) EH233_22930 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) EH233_22940 ENOG4105BZU Histidine kinase EH233_22960 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EH233_22965 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EH233_22975 ENOG41082EZ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EH233_22980 ENOG4105D4A Cell wall formation (By similarity) EH233_22985 ENOG4105DFU Cell wall formation (By similarity) EH233_22990 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EH233_22995 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EH233_23000 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EH233_23010 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EH233_23015 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EH233_23020 ENOG4107YCR Transcriptional regulator, ARSR family EH233_23030 ENOG4107QP0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EH233_23050 ENOG4105BZU Histidine kinase EH233_23055 ENOG4105BZU Histidine kinase EH233_23060 ENOG4105BZU Histidine kinase EH233_23110 ENOG4105CAK Cell division ATP-binding protein ftsE EH233_23120 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_23125 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EH233_23165 ENOG4105DBV ornithine carbamoyltransferase EH233_23220 ENOG4105EYH Exonuclease EH233_23250 ENOG4105HFZ Membrane EH233_23285 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_23305 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EH233_23310 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) EH233_23315 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) EH233_23355 ENOG4105P8Q Curli production assembly transport component CsgG EH233_23410 ENOG4105C1V Peptidase, M16 EH233_23430 ENOG4107TIF Phenazine biosynthesis protein, PhzF family EH233_23435 ENOG4107RAQ aminopeptidase EH233_23440 ENOG4108IV0 ABC, transporter EH233_23445 ENOG4105C0Z ABC transporter EH233_23455 ENOG4105C32 Amino acid ABC transporter (Permease) EH233_23460 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein EH233_23475 ENOG41082B1 30S ribosomal protein S16 EH233_23485 ENOG4105VCC 30S ribosomal protein S21 EH233_23510 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EH233_23520 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EH233_23530 ENOG4107WMZ Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EH233_23575 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EH233_23580 ENOG4105D9P serine threonine protein kinase EH233_23595 ENOG4105DTD Dehydrogenase EH233_23610 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EH233_23620 ENOG4105C8S subunit m EH233_23630 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EH233_23645 ENOG4105D9P serine threonine protein kinase EH233_23650 ENOG4105CK2 sodium dicarboxylate symporter EH233_23665 ENOG4105FDK ABC transporter EH233_23670 ENOG4105DSE periplasmic solute binding protein EH233_23675 ENOG4105D52 delta-aminolevulinic acid dehydratase EH233_23680 ENOG4105C22 threonyL-tRNA synthetase EH233_23690 ENOG4105CKI cobalamin synthesis protein EH233_23695 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EH233_23745 ENOG4108JJA ABC, transporter EH233_23755 ENOG4108PWY Carbohydrate-selective porin OprB EH233_23770 ENOG4105C7H Helicase, RecD TraA family EH233_23835 ENOG4108PJD permease EH233_23840 ENOG4105BZU Histidine kinase EH233_23845 ENOG4106KE4 Dehydrogenase EH233_23855 ENOG4105G5N sensor protein EH233_23885 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EH233_23890 ENOG4105D0M Protease HtpX homolog EH233_23895 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EH233_23900 ENOG4108K5P (LipO)protein EH233_23910 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) EH233_23915 ENOG4105DGU Histone deacetylase EH233_23925 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP EH233_23935 ENOG4107QJE Chromosome Partitioning Protein EH233_23945 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EH233_23950 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EH233_23955 ENOG4105M3Z response regulator EH233_23970 ENOG4105CBS Chea signal transduction histidine kinase EH233_23980 ENOG4105EUB pirin domain protein EH233_23985 ENOG4107XNQ Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EH233_23990 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EH233_24000 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EH233_24025 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EH233_24030 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_24035 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EH233_24040 ENOG4105KHC sulfurtransferase EH233_24060 ENOG4105CMV Succinyl-CoA synthetase subunit beta EH233_24065 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EH233_24070 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) EH233_24075 ENOG4105CUG Oligopeptidase b EH233_24085 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EH233_24090 ENOG4107P5I polyketide synthase EH233_24110 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EH233_24125 ENOG4105E0X reductase EH233_24145 ENOG4105CAN Short-chain dehydrogenase reductase Sdr EH233_24155 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EH233_24160 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EH233_24165 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EH233_24170 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EH233_24175 ENOG4107QPR SAICAR synthetase EH233_24185 ENOG4105F8J Adenylate Guanylate cyclase EH233_24190 ENOG4105BZF Glycosyl transferase (Group 1 EH233_24200 ENOG4105D0M Protease HtpX homolog EH233_24225 ENOG4105BZU Histidine kinase EH233_24295 ENOG4108K7V UPF0284 protein EH233_24305 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EH233_24330 ENOG4105DU0 nucleoside hydrolase EH233_24340 ENOG4105C0H protease EH233_24345 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EH233_24355 ENOG4105VN1 Heat shock protein EH233_24360 ENOG4105KPY Small multidrug resistance protein EH233_24370 ENOG4105DA5 (ABC) transporter EH233_24390 ENOG4105CP7 Triose-phosphate isomerase EH233_24395 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EH233_24425 ENOG4105D52 delta-aminolevulinic acid dehydratase EH233_24430 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EH233_24435 ENOG4105D0M Protease HtpX homolog EH233_24450 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_24460 ENOG4105F23 Fibronectin-binding protein EH233_24470 ENOG4105ERG peptidase m48, ste24p EH233_24475 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EH233_24485 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EH233_24490 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EH233_24500 ENOG4107RU9 Transcriptional regulator, Crp Fnr family EH233_24505 ENOG4108R0D protein with myosin-like EH233_24520 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EH233_24530 ENOG4105C0D helicase EH233_24545 ENOG4105CNF WD-40 repeat protein EH233_24545 ENOG4105CNF WD-40 repeat protein EH233_24555 ENOG4108F3G Type I restriction-modification system, R subunit EH233_24585 ENOG4107QTH restriction modification system DNA specificity domain EH233_24605 ENOG4105CXT aspartate transcarbamylase EH233_24610 ENOG4105C08 Histidine kinase EH233_24620 ENOG4107QN1 sodium solute EH233_24630 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EH233_24640 ENOG4108MV2 Involved in light-induced Na( )-dependent proton extrusion. Also seems to be involved in CO(2) transport (By similarity) EH233_24660 ENOG4106CD9 glycosyl transferase group 1 EH233_24670 ENOG4108JJA ABC, transporter EH233_24675 ENOG4105C42 Type I secretion membrane fusion protein (HlyD EH233_24690 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EH233_24700 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EH233_24705 ENOG4108V5Q transglutaminase-like protein EH233_24715 ENOG4108RXX maleylacetoacetate isomerase EH233_24720 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EH233_24730 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EH233_24735 ENOG4105E2Z phosphate ABC transporter (Permease EH233_24740 ENOG4105C8U phosphate abc transporter EH233_24755 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EH233_24765 ENOG4108JQC penicillin-binding protein 1A EH233_24780 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EH233_24795 ENOG4107S17 Phosphate-binding protein EH233_24825 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EH233_24875 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EH233_24905 ENOG4105FA0 parb-like partition protein EH233_24910 ENOG4107QJE Chromosome Partitioning Protein EH233_24915 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II EH233_24925 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin EH233_24935 ENOG4108Z6B deaminase EH233_24965 ENOG4105BZU Histidine kinase EH233_24970 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EH233_24975 ENOG4105BZU Histidine kinase EH233_24985 ENOG4105BZU Histidine kinase EH233_24990 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EH233_25010 ENOG4105CXN decarboxylase EH233_25020 ENOG4105CBT Fructose-1,6-bisphosphatase EH233_25030 ENOG4105CHM Aminotransferase EH233_25040 ENOG4105DJZ UPF0182 protein EH233_25060 ENOG4105GVR general secretion pathway protein D EH233_25090 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EH233_25100 ENOG4108Z0R Transferase EH233_25140 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EH233_25175 ENOG4105WH1 Two component transcriptional regulator luxr family EH233_25180 ENOG4105EWM Histidine kinase EH233_25255 ENOG4105EWK phytoene EH233_25280 ENOG4105CPQ Dehydrogenase EH233_25285 ENOG4105D5K Hemolysin activator protein EH233_25305 ENOG4105IB0 filamentous hemagglutinin family outer membrane protein EH233_25315 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) EH233_25345 ENOG4108K9Q Controls heterocyst differentiation. Has both a protease and a DNA-binding activity (By similarity) EH233_25350 ENOG4105CHM Aminotransferase EH233_25355 ENOG4105N6Y Thioredoxin EH233_25385 ENOG4108IPT Naphthoate synthase EH233_25400 ENOG4105DBI uridine monophosphokinase EH233_25415 ENOG4105W5Q DNA repair protein (RadC EH233_25435 ENOG4105DCF alanine dehydrogenase EH233_25460 ENOG4105CVJ phosphoglycerate mutase EH233_25480 ENOG4105CNN ABC, transporter EH233_25485 ENOG4105C2J ABC transporter EH233_25490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EH233_25495 ENOG4105ETE Transcriptional regulator (LacI family EH233_25500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EH233_25535 ENOG4105CMQ Chloride channel EH233_25545 ENOG4105KZX Pterin carbinolamine dehydratase EH233_25550 ENOG4108PWY Carbohydrate-selective porin OprB EH233_25565 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EH233_25590 ENOG4105CBX hi0933 family EH233_25640 ENOG4105D2N Aldolase EH233_25655 ENOG4108I6A alcohol dehydrogenase EH233_25665 ENOG4105MSA Photosystem II reaction center W protein EH233_25670 ENOG4105EPU Molybdenum cofactor synthesis domain protein EH233_25685 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EH233_25695 ENOG4105W3H MtN3 and saliva related transmembrane protein EH233_25700 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EH233_25740 ENOG4105J0U photosystem II EH233_25750 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EH233_25760 ENOG4105PSV Polysaccharide Biosynthesis Protein EH233_25765 ENOG4108SHN Glycosyl transferase, family 2 EH233_25770 ENOG4108SHN Glycosyl transferase, family 2 EH233_25775 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_25790 ENOG4108ZPC Polysaccharide pyruvyl transferase EH233_25795 ENOG4105PSV Polysaccharide Biosynthesis Protein EH233_25800 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_25810 ENOG4105K64 Glycosyl transferase, family 2 EH233_25825 ENOG4105D75 Capsular exopolysaccharide family EH233_25830 ENOG4105CG5 Glycosyl transferase (Group 1 EH233_25835 ENOG4108KMV Glycosyl transferase (Group 1 EH233_25845 ENOG4105D9P serine threonine protein kinase EH233_25855 ENOG410902K Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EH233_25880 ENOG4105DY8 decarboxylase EH233_25905 ENOG4105CNG UPF0061 protein EH233_25940 ENOG4105BZU Histidine kinase EH233_25945 ENOG4108WXF Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation EH233_25950 ENOG4108ZGN Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity) EH233_25955 ENOG4105EHU Circadian clock protein KaiC EH233_25970 ENOG4105C01 Dihydroxy-acid dehydratase EH233_26080 ENOG4105BZU Histidine kinase EH233_26095 ENOG4105FIK Inherit from COG: dihydropteroate synthase EH233_26105 ENOG41080UQ Transcriptional regulator EH233_26140 ENOG4105C0H protease EH233_26150 ENOG4105C0P Mg chelatase subunit ChlI EH233_26155 ENOG4107YU2 histidine triad (hIT) protein EH233_26165 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EH233_26185 ENOG4105CPK Glycosyl transferase (Group 1 EH233_26190 ENOG4107RGC Glycosyl transferase, family 2 EH233_26205 ENOG4105CNW domain protein EH233_26215 ENOG4105CNW domain protein EH233_26230 ENOG4105D3Q Sugar transferase EH233_26235 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family EH233_26255 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EH233_26280 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EH233_26305 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EH233_26310 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EH233_26315 ENOG4107YX3 NADH dehydrogenase subunit j EH233_26320 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EH233_26325 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EH233_26350 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EH233_26370 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EH233_26380 ENOG4108NSV This is one of the two reaction center proteins of photosystem II EH233_26415 ENOG4105D82 Glutamate dehydrogenase EH233_26420 ENOG4107RA9 decarboxylase EH233_26430 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) EH233_26440 ENOG4108V1U phospholipid-binding protein EH233_26445 ENOG4108HMN Caspase domain EH233_26465 ENOG4107YBR Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EH233_26470 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EH233_26480 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EH233_26495 ENOG4105E5Q amino acid AbC transporter EH233_26510 ENOG41075E2 Photosystem I reaction centre subunit IX / PsaJ EH233_26520 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EH233_26525 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) EH233_26530 ENOG4108RAV Conserved protein EH233_26535 ENOG4108K3A Glutathione S-transferase EH233_26540 ENOG41063C6 UPF0235 protein EH233_26555 ENOG4105H0Z Hemerythrin HHE cation binding domain protein EH233_26575 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) EH233_26585 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EH233_26590 ENOG4105EHG Permease protein EH233_26595 ENOG4105E0A ABC, transporter EH233_26605 ENOG4105C8Y Acetylornithine aminotransferase EH233_26610 ENOG4105E0R Deoxyhypusine synthase EH233_26625 ENOG4105CE1 Ferrous iron transport protein b EH233_26640 ENOG4105C4M (Ubiquinol oxidase) subunit I EH233_26645 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EH233_26655 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EH233_26680 ENOG4105CD5 CoA-binding domain protein EH233_26695 ENOG4105EMU Dehydrogenase EH233_26745 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EH233_26750 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EH233_26780 ENOG4108R6K riboflavin synthase, subunit alpha EH233_26785 ENOG41063SB peptidase EH233_26790 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EH233_26800 ENOG4105C09 Bile acid EH233_26805 ENOG4106MP8 UPF0754 membrane protein EH233_26810 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) EH233_26815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EH233_26840 ENOG4108W6C Dehydrogenase EH233_26860 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EH233_26865 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EH233_26875 ENOG4105BZU Histidine kinase EH233_26885 ENOG4105BZU Histidine kinase EH233_26890 ENOG4105PGM cation diffusion facilitator family transporter EH233_26915 ENOG4105C12 Phosphoribosylglycinamide synthetase EH233_26955 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EH233_26985 ENOG4105BZU Histidine kinase EH233_27000 ENOG4105CPF Cell wall formation (By similarity) EH233_27015 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EH233_27020 ENOG4108R99 pseudouridine synthase EH233_27025 ENOG4105BZU Histidine kinase EH233_27090 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EH233_27095 ENOG4105D0M Protease HtpX homolog EH233_27140 ENOG4108M24 von Willebrand factor, type A EH233_27150 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding EH233_27195 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EH233_27220 ENOG4105CNF WD-40 repeat protein EH233_27230 ENOG4105D3R alkyl hydroperoxide reductase EH233_27250 ENOG4107STW synthase EH233_27260 ENOG4107R1X phosphohexokinase EH233_27265 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EH233_27270 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EH233_27295 ENOG4107SC1 transglycosylase EH233_27350 ENOG4105C19 ABC transporter EH233_27395 ENOG4108Z0Z intracellular protease Pfpi family EH233_27450 ENOG4105CRK lysyL-tRNA synthetase EH233_27470 ENOG4105D0M Protease HtpX homolog EH233_27510 ENOG4105D3G Pseudouridine synthase EH233_27540 ENOG4105E0A ABC, transporter EH233_27545 ENOG4105EHG Permease protein EH233_27550 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EH233_27555 ENOG4105CNM Receptor EH233_27580 ENOG4105CA0 peroxidase EH233_27590 ENOG4105E0R Deoxyhypusine synthase EH233_27600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EH233_27610 ENOG41060KK Stabilizes the structure of photosystem II oxygen- evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation (By similarity) EH233_27615 ENOG4108IYU L-aspartate oxidase EH233_27625 ENOG4105BZU Histidine kinase EH233_27630 ENOG4105CVB Vitamin K epoxide reductase EH233_27640 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EH233_27660 ENOG4105C0D helicase EH233_27685 ENOG4108HMN Caspase domain EH233_27705 ENOG4105C0W non-ribosomal peptide synthetase EH233_27725 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EH233_27730 ENOG4105QPS Monooxygenase EH233_27740 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EH233_27750 ENOG4105NP4 Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis (By similarity) EH233_27770 ENOG4105D82 Glutamate dehydrogenase EH233_27780 ENOG4105CI2 imidazolone-5-propionate hydrolase EH233_27790 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EH233_27795 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EH233_27830 ENOG4108Z03 MAF-like protein EH233_27855 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EH233_27875 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EH233_27880 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EH233_27885 ENOG4107RSM transcriptional regulator EH233_27890 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EH233_27915 ENOG4105BZ1 (ABC) transporter EH233_27945 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit EH233_27950 ENOG4105C37 (CBS) domain EH233_27955 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EH233_27965 ENOG4107T5V SNARE associated Golgi EH233_27980 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EH233_27985 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EH233_28030 ENOG4105CTK cobaltochelatase, cobn subunit EH233_28035 ENOG4107WDG serine threonine protein kinase EH233_28045 ENOG4107WDG serine threonine protein kinase EH233_28060 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EH233_28070 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EH233_28075 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EH233_28080 ENOG4105F0N pyrophosphate phospho-hydrolase EH233_28110 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II EH233_28115 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EH233_28120 ENOG4105EWN Heme oxygenase EH233_28125 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EH233_28130 ENOG4105ESV Glycosyl transferase, family 4 EH233_28155 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EH233_28215 ENOG4105CJ3 phosphate transporter EH233_28220 ENOG41089UC methyltransferase, type 11 EH233_28255 ENOG4105D44 asparaginase EH233_28285 ENOG4105F32 YngK protein EH233_28295 ENOG41087WU EH233_28335 ENOG4107STW synthase EH233_28345 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EH233_28375 ENOG4105FA2 dna polymerase iii EH233_28405 ENOG4105K70 DNA-binding protein EH233_28440 ENOG4105DN3 alpha-2-macroglobulin domain protein EH233_28445 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EH233_28530 ENOG4107FCW Abortive infection protein EH233_28580 ENOG4105DDQ anthranilate synthase EH233_28590 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EH233_28615 ENOG4105C22 threonyL-tRNA synthetase EH233_28620 ENOG4105CNF WD-40 repeat protein EH233_28655 ENOG4105C89 phosphohexose isomerase EH233_28665 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II EH233_28705 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EH233_28725 ENOG4105CNW domain protein EH233_28730 ENOG4105CNW domain protein EH233_28740 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EH233_28815 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EH233_28855 ENOG4105DSE periplasmic solute binding protein EH233_28860 ENOG4105DIK (ABC) transporter EH233_28890 ENOG4105CNF WD-40 repeat protein EH233_28920 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EH233_28970 ENOG4107YCR Transcriptional regulator, ARSR family EH233_28985 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EH233_29020 ENOG4105EKQ RNA-directed DNA polymerase EH233_29035 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EH233_29050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EH233_29060 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EH233_29065 ENOG4105C0Z ABC transporter EH233_29075 ENOG4105DF7 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) EH233_29080 ENOG4105CC5 ABC transporter EH233_29120 ENOG4107SCA Formamidase (EC 3.5.1.49) EH233_29120 ENOG4107SCA Formamidase (EC 3.5.1.49) EH233_29125 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EH233_29230 ENOG4105D6H One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity)