locus-tag	class	description
AWH56_000005	COG1940	carbohydrate kinase activity
AWH56_000010	COG3842	ATPase activity
AWH56_000030	COG0697	spore germination
AWH56_000035	COG1363	Peptidase, m42
AWH56_000045	COG0705	Rhomboid family
AWH56_000045	COG0457	Tetratricopeptide repeat
AWH56_000065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWH56_000070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWH56_000085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AWH56_000090	COG1543	Belongs to the glycosyl hydrolase 57 family
AWH56_000115	COG0768	penicillin binding
AWH56_000120	COG0477	Major facilitator Superfamily
AWH56_000125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWH56_000130	COG1968	undecaprenyl-diphosphatase activity
AWH56_000165	COG5521	maltodextrose utilization protein MalA
AWH56_000175	COG4086	secreted protein
AWH56_000180	COG2814	Major facilitator Superfamily
AWH56_000185	COG1388	LysM domain
AWH56_000190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AWH56_000200	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AWH56_000205	COG0735	belongs to the Fur family
AWH56_000210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWH56_000215	COG1121	(ABC) transporter
AWH56_000225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWH56_000230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWH56_000235	COG1121	(ABC) transporter
AWH56_000245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AWH56_000250	COG0513	Belongs to the DEAD box helicase family
AWH56_000260	COG1329	Transcriptional regulator
AWH56_000265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AWH56_000270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWH56_000275	COG2384	SAM-dependent methyltransferase
AWH56_000290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWH56_000295	COG0358	DNA primase activity
AWH56_000300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWH56_000305	COG0517	IMP dehydrogenase activity
AWH56_000310	COG1381	Involved in DNA repair and RecF pathway recombination
AWH56_000320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWH56_000325	COG0295	cytidine deaminase activity
AWH56_000335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AWH56_000340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWH56_000345	COG1480	7TM receptor with intracellular HD hydrolase
AWH56_000350	COG1702	phosphate starvation-inducible protein PhoH
AWH56_000370	COG4864	UPF0365 protein
AWH56_000375	COG1030	water channel activity
AWH56_000380	COG1610	YqeY-like protein
AWH56_000385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWH56_000390	COG1283	sodium-dependent phosphate transmembrane transporter activity
AWH56_000395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWH56_000400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWH56_000405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AWH56_000410	COG2264	protein methyltransferase activity
AWH56_000415	COG0484	heat shock protein binding
AWH56_000420	COG0443	Heat shock 70 kDa protein
AWH56_000425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWH56_000430	COG1420	regulation of RNA biosynthetic process
AWH56_000435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWH56_000440	COG0481	GTPase activity
AWH56_000450	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWH56_000460	COG0268	Binds directly to 16S ribosomal RNA
AWH56_000465	COG1466	dna polymerase III delta subunit
AWH56_000475	COG2333	competence protein COMEC
AWH56_000475	COG0658	competence protein
AWH56_000480	COG2131	deaminase
AWH56_000490	COG1596	polysaccharide export
AWH56_000490	COG1555	photosystem II stabilization
AWH56_000500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWH56_000505	COG2226	methyltransferase
AWH56_000510	COG2996	Protein conserved in bacteria
AWH56_000515	COG0799	negative regulation of ribosome biogenesis
AWH56_000520	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWH56_000525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWH56_000530	COG1534	Rna-binding protein
AWH56_000535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWH56_000540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWH56_000555	COG2111	Na H antiporter
AWH56_000555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_000560	COG2111	Na H antiporter
AWH56_000565	COG1006	Multisubunit Na H antiporter MnhC subunit
AWH56_000570	COG0651	ATP synthesis coupled electron transport
AWH56_000575	COG1863	multisubunit Na H antiporter MnhE subunit
AWH56_000580	COG2212	antiporter activity
AWH56_000585	COG1320	monovalent cation:proton antiporter activity
AWH56_000595	COG0247	lactate metabolic process
AWH56_000600	COG0277	FAD linked oxidase domain protein
AWH56_000605	COG3835	regulator
AWH56_000610	COG0688	phosphatidylethanolamine metabolic process
AWH56_000615	COG1183	phosphatidylcholine synthase activity
AWH56_000625	COG0617	tRNA 3'-terminal CCA addition
AWH56_000625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_000625	COG3620	sequence-specific DNA binding
AWH56_000640	COG0655	NAD(P)H dehydrogenase (quinone) activity
AWH56_000645	COG1846	Transcriptional regulator
AWH56_000710	COG1309	transcriptional regulator
AWH56_000715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWH56_000720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWH56_000725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AWH56_000730	COG1024	Enoyl-CoA hydratase
AWH56_000735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWH56_000740	COG0511	ligase activity, forming carbon-carbon bonds
AWH56_000745	COG0439	Biotin carboxylase
AWH56_000750	COG1960	acyl-CoA dehydrogenase activity
AWH56_000780	COG2239	Acts as a magnesium transporter
AWH56_000790	COG0366	Alpha amylase catalytic
AWH56_000795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWH56_000805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AWH56_000820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWH56_000830	COG0768	penicillin binding
AWH56_000835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWH56_000840	COG0572	uridine kinase
AWH56_000845	COG0826	peptidase U32
AWH56_000850	COG0826	peptidase U32
AWH56_000860	COG4122	O-methyltransferase activity
AWH56_000865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWH56_000870	COG3906	Belongs to the UPF0473 family
AWH56_000880	COG4472	Bacterial protein of unknown function (DUF965)
AWH56_000885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWH56_000890	COG0628	permease
AWH56_000910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWH56_000920	COG0482	sulfurtransferase activity
AWH56_000925	COG1104	cysteine desulfurase activity
AWH56_000930	COG1959	2 iron, 2 sulfur cluster binding
AWH56_000935	COG2364	Membrane
AWH56_000940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWH56_000950	COG1556	Lactate utilization protein
AWH56_000955	COG1139	Iron-sulfur cluster binding protein
AWH56_000960	COG0247	lactate metabolic process
AWH56_000965	COG1620	l-lactate permease
AWH56_000970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AWH56_000980	COG0460	homoserine dehydrogenase
AWH56_000985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWH56_000990	COG0124	histidyl-tRNA synthetase
AWH56_001010	COG1490	D-aminoacyl-tRNA deacylase activity
AWH56_001015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWH56_001020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWH56_001025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWH56_001025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWH56_001030	COG5416	Lipopolysaccharide assembly protein A domain
AWH56_001035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWH56_001040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_001040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_001045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_001045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_001060	COG2244	polysaccharide biosynthetic process
AWH56_001070	COG2323	membrane
AWH56_001085	COG1862	Preprotein translocase
AWH56_001090	COG0343	queuine tRNA-ribosyltransferase activity
AWH56_001105	COG2255	four-way junction helicase activity
AWH56_001110	COG0632	four-way junction helicase activity
AWH56_001125	COG1388	LysM domain
AWH56_001135	COG0157	Belongs to the NadC ModD family
AWH56_001140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AWH56_001145	COG1104	cysteine desulfurase activity
AWH56_001150	COG1827	regulation of RNA biosynthetic process
AWH56_001155	COG0077	Prephenate dehydratase
AWH56_001160	COG4492	Belongs to the UPF0735 family
AWH56_001165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AWH56_001170	COG3290	protein histidine kinase activity
AWH56_001175	COG1116	anion transmembrane transporter activity
AWH56_001190	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AWH56_001195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AWH56_001200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AWH56_001205	COG0697	spore germination
AWH56_001225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_001230	COG0785	Cytochrome C biogenesis protein
AWH56_001235	COG1473	amidohydrolase
AWH56_001250	COG4473	ABC transporter
AWH56_001255	COG1131	(ABC) transporter
AWH56_001260	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_001265	COG0537	adenosine 5'-monophosphoramidase activity
AWH56_001270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AWH56_001285	COG1846	Transcriptional regulator
AWH56_001310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWH56_001325	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_001330	COG2770	Histidine kinase
AWH56_001330	COG2205	protein histidine kinase activity
AWH56_001335	COG0745	RESPONSE REGULATOR receiver
AWH56_001355	COG0420	3'-5' exonuclease activity
AWH56_001370	COG0561	phosphatase activity
AWH56_001375	COG3679	Belongs to the UPF0342 family
AWH56_001380	COG4399	Belongs to the UPF0754 family
AWH56_001385	COG0189	ligase activity
AWH56_001390	COG0189	ligase activity
AWH56_001395	COG0189	ligase activity
AWH56_001400	COG0189	ligase activity
AWH56_001420	COG2508	Transcriptional regulator
AWH56_001425	COG3842	ATPase activity
AWH56_001440	COG0840	transmembrane signaling receptor activity
AWH56_001445	COG0840	transmembrane signaling receptor activity
AWH56_001465	COG1741	Belongs to the pirin family
AWH56_001470	COG0702	epimerase
AWH56_001475	COG1132	(ABC) transporter
AWH56_001480	COG1132	(ABC) transporter
AWH56_001485	COG3764	Sortase (surface protein transpeptidase)
AWH56_001500	COG0617	tRNA 3'-terminal CCA addition
AWH56_001500	COG0517	IMP dehydrogenase activity
AWH56_001500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_001540	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_001545	COG3706	GGDEF domain
AWH56_001575	COG0783	Belongs to the Dps family
AWH56_001595	COG1834	amidinotransferase
AWH56_001600	COG1278	Cold shock
AWH56_001610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AWH56_001615	COG0697	spore germination
AWH56_001640	COG1396	sequence-specific DNA binding
AWH56_001680	COG1131	(ABC) transporter
AWH56_001685	COG0697	spore germination
AWH56_001705	COG1187	pseudouridine synthase activity
AWH56_001725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_001745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWH56_001755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWH56_001755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWH56_001755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWH56_001760	COG1105	Belongs to the carbohydrate kinase PfkB family
AWH56_001765	COG1349	DNA-binding transcription factor activity
AWH56_001770	COG0586	Pfam SNARE associated Golgi protein
AWH56_001775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWH56_001800	COG4512	PFAM Accessory gene regulator B
AWH56_001810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AWH56_001820	COG1910	domain protein
AWH56_001835	COG0586	Pfam SNARE associated Golgi protein
AWH56_001840	COG2112	serine threonine protein kinase
AWH56_001855	COG0477	Major facilitator Superfamily
AWH56_001860	COG0471	metal ion transport
AWH56_001860	COG3273	potassium ion transport
AWH56_001875	COG2409	Drug exporters of the RND superfamily
AWH56_001890	COG0347	Belongs to the P(II) protein family
AWH56_001920	COG1785	Belongs to the alkaline phosphatase family
AWH56_001930	COG1968	undecaprenyl-diphosphatase activity
AWH56_001935	COG0772	Belongs to the SEDS family
AWH56_002065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_002150	COG3243	poly(R)-hydroxyalkanoic acid synthase
AWH56_002155	COG2124	cytochrome p450
AWH56_002170	COG1924	4 iron, 4 sulfur cluster binding
AWH56_002210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWH56_002215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWH56_002225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWH56_002230	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AWH56_002240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWH56_002240	COG3153	acetyltransferase
AWH56_002260	COG1079	Belongs to the binding-protein-dependent transport system permease family
AWH56_002265	COG4603	Belongs to the binding-protein-dependent transport system permease family
AWH56_002270	COG3845	ABC transporter
AWH56_002275	COG1744	ABC transporter substrate-binding protein PnrA-like
AWH56_002315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_002320	COG2201	protein-glutamate methylesterase activity
AWH56_002325	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AWH56_002330	COG3005	denitrification pathway
AWH56_002335	COG4187	Peptidase family M20/M25/M40
AWH56_002345	COG5002	protein histidine kinase activity
AWH56_002350	COG5001	Diguanylate cyclase
AWH56_002350	COG2203	Gaf domain
AWH56_002350	COG3706	GGDEF domain
AWH56_002350	COG4251	negative regulation of phosphorylation
AWH56_002355	COG4608	Belongs to the ABC transporter superfamily
AWH56_002360	COG0444	Belongs to the ABC transporter superfamily
AWH56_002365	COG0601	transmembrane transport
AWH56_002370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_002385	COG1858	cytochrome C peroxidase
AWH56_002395	COG1937	Protein conserved in bacteria
AWH56_002400	COG0425	Belongs to the sulfur carrier protein TusA family
AWH56_002405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_002405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_002410	COG0425	Belongs to the sulfur carrier protein TusA family
AWH56_002410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_002415	COG2210	Belongs to the sulfur carrier protein TusA family
AWH56_002440	COG0437	4 iron, 4 sulfur cluster binding
AWH56_002450	COG4191	Histidine kinase
AWH56_002465	COG1131	(ABC) transporter
AWH56_002475	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWH56_002480	COG0644	oxidoreductase
AWH56_002495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWH56_002505	COG1131	(ABC) transporter
AWH56_002525	COG4585	Histidine kinase
AWH56_002530	COG2197	response regulator
AWH56_002545	COG0840	transmembrane signaling receptor activity
AWH56_002555	COG3584	3D domain protein
AWH56_002555	COG1388	LysM domain
AWH56_002565	COG3858	chitin binding
AWH56_002635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_002640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWH56_002655	COG0109	protoheme IX farnesyltransferase activity
AWH56_002665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_002670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_002680	COG1917	Cupin 2, conserved barrel domain protein
AWH56_002680	COG2207	Transcriptional regulator
AWH56_002685	COG3620	sequence-specific DNA binding
AWH56_002695	COG2259	Doxx family
AWH56_002700	COG1733	regulation of RNA biosynthetic process
AWH56_002705	COG4974	Belongs to the 'phage' integrase family
AWH56_002810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_002815	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_002820	COG2301	Belongs to the HpcH HpaI aldolase family
AWH56_002825	COG1063	alcohol dehydrogenase
AWH56_002830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_002830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_002840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_002845	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_002875	COG4974	Belongs to the 'phage' integrase family
AWH56_002880	COG0582	viral genome integration into host DNA
AWH56_002885	COG4974	Belongs to the 'phage' integrase family
AWH56_002900	COG1074	ATP-dependent DNA helicase activity
AWH56_002960	COG1404	Belongs to the peptidase S8 family
AWH56_002965	COG2718	Belongs to the UPF0229 family
AWH56_002980	COG2766	serine protein kinase
AWH56_002985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_002995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWH56_003005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWH56_003025	COG2207	Transcriptional regulator
AWH56_003045	COG3852	Histidine kinase
AWH56_003055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AWH56_003065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AWH56_003095	COG1484	DNA-dependent DNA replication
AWH56_003115	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AWH56_003125	COG2201	protein-glutamate methylesterase activity
AWH56_003245	COG0735	belongs to the Fur family
AWH56_003250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_003255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AWH56_003275	COG4555	ABC transporter
AWH56_003280	COG1316	TRANSCRIPTIONal
AWH56_003285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AWH56_003290	COG0070	glutamate synthase
AWH56_003290	COG0069	glutamate synthase activity
AWH56_003290	COG0067	glutamate synthase
AWH56_003295	COG4129	membrane
AWH56_003320	COG1132	(ABC) transporter
AWH56_003325	COG3557	Belongs to the UPF0374 family
AWH56_003345	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_003360	COG0436	Aminotransferase
AWH56_003375	COG2059	Chromate
AWH56_003380	COG2059	Chromate
AWH56_003385	COG0405	Gamma-glutamyltransferase
AWH56_003395	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_003400	COG1194	a g-specific adenine glycosylase
AWH56_003410	COG1988	membrane-bound metal-dependent
AWH56_003435	COG1620	l-lactate permease
AWH56_003440	COG2137	regulation of response to DNA damage stimulus
AWH56_003445	COG1090	epimerase
AWH56_003475	COG4585	Histidine kinase
AWH56_003480	COG2197	response regulator
AWH56_003490	COG0456	acetyltransferase
AWH56_003495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AWH56_003500	COG1917	Cupin 2, conserved barrel domain protein
AWH56_003520	COG0431	NADPH-dependent FMN reductase
AWH56_003540	COG2197	response regulator
AWH56_003545	COG4585	Histidine kinase
AWH56_003570	COG3033	Beta-eliminating lyase
AWH56_003585	COG2358	TRAP transporter, solute receptor (TAXI family
AWH56_003595	COG2197	response regulator
AWH56_003600	COG4585	Histidine kinase
AWH56_003605	COG3239	Fatty acid desaturase
AWH56_003665	COG2197	response regulator
AWH56_003685	COG1183	phosphatidylcholine synthase activity
AWH56_003690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_003705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWH56_003770	COG4974	Belongs to the 'phage' integrase family
AWH56_003785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_003795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWH56_003805	COG3621	Patatin-like phospholipase
AWH56_003850	COG4372	Transposase
AWH56_003875	COG4372	Transposase
AWH56_003900	COG2801	Transposase and inactivated derivatives
AWH56_003905	COG2801	Transposase and inactivated derivatives
AWH56_003910	COG2801	Transposase and inactivated derivatives
AWH56_003920	COG1555	photosystem II stabilization
AWH56_003920	COG3568	Endonuclease Exonuclease Phosphatase
AWH56_003935	COG1320	monovalent cation:proton antiporter activity
AWH56_003940	COG2212	antiporter activity
AWH56_003945	COG1863	multisubunit Na H antiporter MnhE subunit
AWH56_003950	COG0651	ATP synthesis coupled electron transport
AWH56_003955	COG1006	Multisubunit Na H antiporter MnhC subunit
AWH56_003960	COG2111	Na H antiporter
AWH56_003965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_003965	COG2111	Na H antiporter
AWH56_004010	COG0719	Fe-S assembly protein
AWH56_004015	COG0822	iron-sulfur transferase activity
AWH56_004020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWH56_004025	COG0719	Fe-S assembly protein
AWH56_004030	COG0396	ATPase activity
AWH56_004045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AWH56_004055	COG1464	Belongs to the NlpA lipoprotein family
AWH56_004060	COG2011	ABC-type metal ion transport system permease component
AWH56_004065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWH56_004085	COG0509	glycine decarboxylation via glycine cleavage system
AWH56_004090	COG1393	Belongs to the ArsC family
AWH56_004100	COG1960	acyl-CoA dehydrogenase activity
AWH56_004105	COG0183	Belongs to the thiolase family
AWH56_004110	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWH56_004110	COG1024	Enoyl-CoA hydratase
AWH56_004120	COG5577	PFAM Coat F domain
AWH56_004145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWH56_004155	COG4447	cellulose binding
AWH56_004160	COG1191	sigma factor activity
AWH56_004200	COG2205	protein histidine kinase activity
AWH56_004205	COG0745	RESPONSE REGULATOR receiver
AWH56_004220	COG0745	RESPONSE REGULATOR receiver
AWH56_004225	COG2217	Heavy metal translocating P-type atpase
AWH56_004230	COG0840	transmembrane signaling receptor activity
AWH56_004260	COG2132	Multicopper oxidase
AWH56_004270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWH56_004300	COG5002	protein histidine kinase activity
AWH56_004315	COG0367	asparagine synthase
AWH56_004320	COG0791	NLP P60 protein
AWH56_004345	COG1393	Belongs to the ArsC family
AWH56_004350	COG0398	Pfam SNARE associated Golgi protein
AWH56_004360	COG4372	Transposase
AWH56_004380	COG3850	Histidine kinase
AWH56_004380	COG5002	protein histidine kinase activity
AWH56_004385	COG0745	RESPONSE REGULATOR receiver
AWH56_004390	COG0367	asparagine synthase
AWH56_004395	COG1388	LysM domain
AWH56_004395	COG0791	NLP P60 protein
AWH56_004410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWH56_004415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AWH56_004420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AWH56_004435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWH56_004460	COG2808	Putative FMN-binding domain
AWH56_004545	COG4974	Belongs to the 'phage' integrase family
AWH56_004590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWH56_004610	COG0557	exoribonuclease II activity
AWH56_004615	COG1647	Serine aminopeptidase, S33
AWH56_004625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWH56_004630	COG0148	phosphopyruvate hydratase activity
AWH56_004635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWH56_004640	COG0149	triose-phosphate isomerase activity
AWH56_004645	COG0126	phosphoglycerate kinase activity
AWH56_004650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWH56_004665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AWH56_004670	COG0740	serine-type endopeptidase activity
AWH56_004675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWH56_004680	COG1481	regulation of sporulation
AWH56_004685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AWH56_004690	COG1660	Displays ATPase and GTPase activities
AWH56_004695	COG1051	belongs to the nudix hydrolase family
AWH56_004700	COG0492	ferredoxin-NADP+ reductase activity
AWH56_004705	COG0457	Tetratricopeptide repeat
AWH56_004710	COG0140	phosphoribosyl-ATP diphosphatase activity
AWH56_004710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AWH56_004715	COG0107	imidazoleglycerol-phosphate synthase activity
AWH56_004720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AWH56_004725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AWH56_004730	COG0131	Imidazoleglycerol-phosphate dehydratase
AWH56_004735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWH56_004740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AWH56_004745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AWH56_004760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWH56_004765	COG0110	maltose O-acetyltransferase activity
AWH56_004775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AWH56_004785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWH56_004790	COG1950	PFAM Membrane protein of
AWH56_004795	COG1983	PspC domain protein
AWH56_004800	COG3595	metallopeptidase activity
AWH56_004805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWH56_004810	COG0556	nucleotide-excision repair
AWH56_004815	COG2223	nitrite transmembrane transporter activity
AWH56_004840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_004845	COG3409	Peptidoglycan-binding domain 1 protein
AWH56_004845	COG0793	Belongs to the peptidase S41A family
AWH56_004850	COG0739	heme binding
AWH56_004855	COG2177	Part of the ABC transporter FtsEX involved in
AWH56_004860	COG2884	Cell division ATP-binding protein ftsE
AWH56_004880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_004890	COG0653	protein targeting
AWH56_004895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AWH56_004900	COG1278	Cold shock
AWH56_004905	COG0367	asparagine synthase
AWH56_004910	COG4990	cell redox homeostasis
AWH56_004920	COG0629	single-stranded DNA binding
AWH56_004950	COG0606	chelatase, subunit chli
AWH56_004955	COG0758	DNA mediated transformation
AWH56_004975	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AWH56_004990	COG3266	domain, Protein
AWH56_004990	COG1361	Conserved repeat domain
AWH56_004990	COG2911	Protein conserved in bacteria
AWH56_005005	COG1516	flagellar protein fliS
AWH56_005010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AWH56_005015	COG1334	flagellar protein FlaG
AWH56_005020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWH56_005025	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AWH56_005030	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AWH56_005045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWH56_005050	COG1256	bacterial-type flagellum assembly
AWH56_005050	COG4786	Flagellar basal body rod
AWH56_005075	COG1040	competence protein
AWH56_005080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWH56_005125	COG1361	Conserved repeat domain
AWH56_005125	COG2911	Protein conserved in bacteria
AWH56_005125	COG3266	domain, Protein
AWH56_005135	COG4824	toxin secretion phage lysis holin
AWH56_005145	COG4974	Belongs to the 'phage' integrase family
AWH56_005240	COG0740	serine-type endopeptidase activity
AWH56_005255	COG4626	Terminase
AWH56_005255	COG1802	Transcriptional regulator
AWH56_005350	COG1061	Type III restriction enzyme res subunit
AWH56_005440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_005450	COG1307	EDD domain protein, DegV family
AWH56_005475	COG1739	Uncharacterized protein family UPF0029
AWH56_005480	COG1316	TRANSCRIPTIONal
AWH56_005485	COG0653	protein targeting
AWH56_005500	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWH56_005535	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_005555	COG0728	peptidoglycan biosynthetic process
AWH56_005565	COG1361	Conserved repeat domain
AWH56_005590	COG0028	Belongs to the TPP enzyme family
AWH56_005595	COG3852	Histidine kinase
AWH56_005655	COG0737	Belongs to the 5'-nucleotidase family
AWH56_005665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWH56_005670	COG0363	glucosamine-6-phosphate deaminase activity
AWH56_005675	COG1940	carbohydrate kinase activity
AWH56_005685	COG1472	Belongs to the glycosyl hydrolase 3 family
AWH56_005700	COG1653	transport
AWH56_005705	COG0395	ABC-type sugar transport system, permease component
AWH56_005710	COG4209	transmembrane transport
AWH56_005720	COG1737	Transcriptional regulator
AWH56_005725	COG3458	cephalosporin-C deacetylase activity
AWH56_005730	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AWH56_005735	COG5578	integral membrane protein
AWH56_005785	COG1744	ABC transporter substrate-binding protein PnrA-like
AWH56_005790	COG0840	transmembrane signaling receptor activity
AWH56_005825	COG4974	Belongs to the 'phage' integrase family
AWH56_005870	COG0596	Alpha beta hydrolase
AWH56_006025	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWH56_006040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWH56_006045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AWH56_006055	COG0438	transferase activity, transferring glycosyl groups
AWH56_006060	COG0728	peptidoglycan biosynthetic process
AWH56_006090	COG5263	repeat protein
AWH56_006090	COG4193	domain, Protein
AWH56_006100	COG0791	NLP P60 protein
AWH56_006105	COG1404	Belongs to the peptidase S8 family
AWH56_006115	COG0791	NLP P60 protein
AWH56_006115	COG1388	LysM domain
AWH56_006120	COG5001	Diguanylate cyclase
AWH56_006120	COG3300	MHYT domain
AWH56_006140	COG4786	Flagellar basal body rod
AWH56_006145	COG4786	Flagellar basal body rod
AWH56_006155	COG1609	Transcriptional regulator
AWH56_006170	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AWH56_006175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AWH56_006190	COG0739	heme binding
AWH56_006195	COG2385	sporulation resulting in formation of a cellular spore
AWH56_006200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWH56_006210	COG4836	Membrane
AWH56_006215	COG1007	ATP synthesis coupled electron transport
AWH56_006225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_006235	COG0839	Belongs to the complex I subunit 6 family
AWH56_006245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AWH56_006250	COG0649	NAD binding
AWH56_006255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWH56_006260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWH56_006265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWH56_006270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AWH56_006275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AWH56_006280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AWH56_006285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AWH56_006290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWH56_006295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AWH56_006305	COG0356	it plays a direct role in the translocation of protons across the membrane
AWH56_006320	COG1404	Belongs to the peptidase S8 family
AWH56_006330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWH56_006335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWH56_006340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AWH56_006350	COG0698	ribose 5-phosphate isomerase
AWH56_006355	COG0840	transmembrane signaling receptor activity
AWH56_006370	COG0009	L-threonylcarbamoyladenylate synthase
AWH56_006390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWH56_006400	COG1435	thymidine kinase activity
AWH56_006405	COG0254	rRNA binding
AWH56_006410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWH56_006415	COG1494	fructose-1,6-bisphosphatase
AWH56_006420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWH56_006425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWH56_006430	COG0191	fructose-bisphosphate aldolase activity
AWH56_006435	COG2204	response regulator
AWH56_006440	COG0504	CTP synthase activity
AWH56_006445	COG3343	RNA polymerase activity
AWH56_006450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_006450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_006450	COG1703	isobutyryl-CoA mutase activity
AWH56_006455	COG1309	transcriptional regulator
AWH56_006460	COG1960	acyl-CoA dehydrogenase activity
AWH56_006465	COG1960	acyl-CoA dehydrogenase activity
AWH56_006470	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWH56_006475	COG0183	Belongs to the thiolase family
AWH56_006480	COG2181	nitrate reductase activity
AWH56_006480	COG0247	lactate metabolic process
AWH56_006490	COG2217	Heavy metal translocating P-type atpase
AWH56_006495	COG0596	Alpha beta hydrolase
AWH56_006505	COG0018	arginyl-trna synthetase
AWH56_006515	COG0010	Belongs to the arginase family
AWH56_006520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AWH56_006525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_006545	COG3465	dGTPase activity
AWH56_006550	COG1078	dGTPase activity
AWH56_006555	COG4844	belongs to the
AWH56_006565	COG0280	phosphate acetyltransferase
AWH56_006570	COG1309	transcriptional regulator
AWH56_006575	COG1902	pentaerythritol trinitrate reductase activity
AWH56_006575	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWH56_006580	COG1024	Enoyl-CoA hydratase
AWH56_006585	COG3253	May function as heme-dependent peroxidase
AWH56_006590	COG3773	Cell wall hydrolase
AWH56_006600	COG2363	Small membrane protein
AWH56_006615	COG5002	protein histidine kinase activity
AWH56_006625	COG2084	Dehydrogenase
AWH56_006630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWH56_006635	COG0494	nUDIX hydrolase
AWH56_006645	COG0423	glycine-tRNA ligase activity
AWH56_006655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWH56_006660	COG0513	Belongs to the DEAD box helicase family
AWH56_006665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AWH56_006670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWH56_006675	COG0011	TIGRFAM Protein of
AWH56_006695	COG3706	GGDEF domain
AWH56_006700	COG0322	excinuclease ABC activity
AWH56_006735	COG0745	RESPONSE REGULATOR receiver
AWH56_006785	COG4974	Belongs to the 'phage' integrase family
AWH56_006825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWH56_006835	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWH56_006875	COG2003	Belongs to the UPF0758 family
AWH56_006900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_006905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWH56_006915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_006920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWH56_006925	COG4853	Protein conserved in bacteria
AWH56_006930	COG4863	YycH protein
AWH56_006935	COG5002	protein histidine kinase activity
AWH56_006940	COG0745	RESPONSE REGULATOR receiver
AWH56_006945	COG1388	LysM domain
AWH56_006945	COG4942	peptidase
AWH56_006980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWH56_006985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AWH56_006995	COG0720	synthase
AWH56_007000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AWH56_007005	COG0305	Participates in initiation and elongation during chromosome replication
AWH56_007010	COG0359	binds to the 23S rRNA
AWH56_007015	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AWH56_007020	COG4241	membrane
AWH56_007025	COG0569	domain protein
AWH56_007030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWH56_007035	COG0629	single-stranded DNA binding
AWH56_007040	COG0360	Binds together with S18 to 16S ribosomal RNA
AWH56_007045	COG0012	GTP binding
AWH56_007050	COG0243	molybdopterin cofactor binding
AWH56_007055	COG4481	Protein conserved in bacteria
AWH56_007060	COG3949	Membrane
AWH56_007075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWH56_007080	COG1475	DNA binding
AWH56_007085	COG1192	Involved in chromosome partitioning
AWH56_007090	COG1475	DNA binding
AWH56_007095	COG0357	Ribosomal RNA small subunit methyltransferase G
AWH56_007100	COG0445	tRNA wobble uridine modification
AWH56_007105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWH56_007110	COG1847	R3H domain protein
AWH56_007115	COG0706	membrane insertase activity
AWH56_007120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWH56_007130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AWH56_007135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AWH56_007140	COG0592	DNA-directed DNA polymerase activity
AWH56_007145	COG2501	S4 domain
AWH56_007160	COG0187	DNA topoisomerase II activity
AWH56_007165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWH56_007170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_007200	COG0517	IMP dehydrogenase activity
AWH56_007200	COG0516	GMP reductase activity
AWH56_007210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AWH56_007215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AWH56_007220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWH56_007225	COG0601	transmembrane transport
AWH56_007230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_007235	COG0444	Belongs to the ABC transporter superfamily
AWH56_007240	COG4608	Belongs to the ABC transporter superfamily
AWH56_007250	COG0601	transmembrane transport
AWH56_007255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_007260	COG0444	Belongs to the ABC transporter superfamily
AWH56_007265	COG4608	Belongs to the ABC transporter superfamily
AWH56_007275	COG0601	transmembrane transport
AWH56_007280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_007285	COG0444	Belongs to the ABC transporter superfamily
AWH56_007290	COG4608	Belongs to the ABC transporter superfamily
AWH56_007300	COG0601	transmembrane transport
AWH56_007305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_007315	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AWH56_007325	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AWH56_007340	COG1138	Cytochrome C-type biogenesis protein
AWH56_007360	COG4555	ABC transporter
AWH56_007370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWH56_007380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_007390	COG0590	tRNA wobble adenosine to inosine editing
AWH56_007400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWH56_007405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWH56_007410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWH56_007455	COG1982	Orn Lys Arg decarboxylase major
AWH56_007460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AWH56_007465	COG3870	Protein conserved in bacteria
AWH56_007470	COG0470	DNA polymerase III
AWH56_007475	COG1774	PSP1 C-terminal conserved region
AWH56_007480	COG4467	Involved in initiation control of chromosome replication
AWH56_007485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWH56_007490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWH56_007495	COG2002	toxin-antitoxin pair type II binding
AWH56_007500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWH56_007500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWH56_007505	COG0084	hydrolase, TatD family'
AWH56_007510	COG3584	3D domain protein
AWH56_007510	COG3583	domain protein
AWH56_007520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWH56_007530	COG4466	Protein conserved in bacteria
AWH56_007540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWH56_007545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWH56_007550	COG0251	oxidation-reduction process
AWH56_007555	COG2088	sporulation resulting in formation of a cellular spore
AWH56_007560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWH56_007565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWH56_007570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AWH56_007575	COG0193	aminoacyl-tRNA hydrolase activity
AWH56_007585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWH56_007590	COG2002	toxin-antitoxin pair type II binding
AWH56_007600	COG2244	polysaccharide biosynthetic process
AWH56_007605	COG3956	TIGRFAM MazG family protein
AWH56_007610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWH56_007625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AWH56_007630	COG1098	S1 RNA binding domain
AWH56_007635	COG2208	phosphoserine phosphatase activity
AWH56_007640	COG2304	oxidoreductase activity
AWH56_007645	COG0515	serine threonine protein kinase
AWH56_007650	COG2966	Psort location CytoplasmicMembrane, score
AWH56_007660	COG0037	tRNA processing
AWH56_007665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AWH56_007670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWH56_007675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AWH56_007680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWH56_007685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWH56_007690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AWH56_007695	COG0512	Glutamine amidotransferase of anthranilate synthase
AWH56_007700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWH56_007705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AWH56_007710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AWH56_007715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWH56_007720	COG1396	sequence-specific DNA binding
AWH56_007725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWH56_007730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWH56_007835	COG1285	pathogenesis
AWH56_007845	COG3880	PFAM UvrB UvrC protein
AWH56_007850	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AWH56_007855	COG0542	response to heat
AWH56_007860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWH56_007865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AWH56_007870	COG4956	integral membrane protein (PIN domain superfamily)
AWH56_007875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AWH56_007880	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AWH56_007885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWH56_007890	COG1045	serine acetyltransferase
AWH56_007895	COG0215	cysteine-tRNA ligase activity
AWH56_007905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWH56_007910	COG3688	RNA-binding protein containing a PIN domain
AWH56_007920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWH56_007925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWH56_007930	COG0250	Participates in transcription elongation, termination and antitermination
AWH56_007940	COG0081	regulation of translation
AWH56_007945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWH56_007950	COG0222	ribosome binding
AWH56_007955	COG2813	Specifically methylates the guanine in position
AWH56_007960	COG0085	RNA polymerase activity
AWH56_007965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWH56_007970	COG1358	cellular component organization or biogenesis
AWH56_007975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWH56_007980	COG0049	tRNA binding
AWH56_007985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWH56_007990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWH56_008005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWH56_008010	COG0088	Forms part of the polypeptide exit tunnel
AWH56_008015	COG0089	rRNA binding
AWH56_008020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWH56_008025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWH56_008030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWH56_008035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWH56_008040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWH56_008045	COG0255	Belongs to the universal ribosomal protein uL29 family
AWH56_008050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWH56_008055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWH56_008060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWH56_008065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWH56_008070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWH56_008075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWH56_008080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWH56_008085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWH56_008090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWH56_008095	COG1841	ribosomal large subunit assembly
AWH56_008100	COG0200	Binds to the 23S rRNA
AWH56_008105	COG0201	protein transport
AWH56_008110	COG0563	adenylate kinase activity
AWH56_008115	COG0024	Methionine aminopeptidase
AWH56_008120	COG2163	COG2163 Ribosomal protein L14E L6E L27E
AWH56_008125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AWH56_008130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AWH56_008140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWH56_008145	COG0202	RNA polymerase activity
AWH56_008150	COG0203	ribosomal protein L17
AWH56_008155	COG1122	ATPase activity
AWH56_008160	COG1122	ATPase activity
AWH56_008165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AWH56_008175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWH56_008180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWH56_008185	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AWH56_008190	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AWH56_008210	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWH56_008215	COG0489	protein tyrosine kinase activity
AWH56_008225	COG2194	sulfuric ester hydrolase activity
AWH56_008235	COG0726	polysaccharide deacetylase
AWH56_008330	COG1595	DNA-templated transcription, initiation
AWH56_008335	COG5662	AntiSigma factor
AWH56_008340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AWH56_008345	COG4856	YbbR-like protein
AWH56_008350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWH56_008355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWH56_008405	COG4974	Belongs to the 'phage' integrase family
AWH56_008410	COG0582	viral genome integration into host DNA
AWH56_008415	COG4974	Belongs to the 'phage' integrase family
AWH56_008465	COG1266	CAAX protease self-immunity
AWH56_008480	COG1484	DNA-dependent DNA replication
AWH56_008660	COG2337	Toxic component of a toxin-antitoxin (TA) module
AWH56_008715	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_008725	COG0551	DNA topoisomerase type I activity
AWH56_008725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWH56_008750	COG0539	negative regulation of cytoplasmic translation
AWH56_008790	COG0629	single-stranded DNA binding
AWH56_008810	COG2003	Belongs to the UPF0758 family
AWH56_009005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWH56_009085	COG4372	Transposase
AWH56_009210	COG3546	catalase activity
AWH56_009215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AWH56_009225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AWH56_009235	COG0437	4 iron, 4 sulfur cluster binding
AWH56_009240	COG3301	Polysulphide reductase, NrfD
AWH56_009250	COG3842	ATPase activity
AWH56_009255	COG4149	molybdate abc transporter
AWH56_009260	COG0745	RESPONSE REGULATOR receiver
AWH56_009265	COG5002	protein histidine kinase activity
AWH56_009300	COG1510	regulation of RNA biosynthetic process
AWH56_009305	COG1595	DNA-templated transcription, initiation
AWH56_009315	COG0840	transmembrane signaling receptor activity
AWH56_009320	COG1988	membrane-bound metal-dependent
AWH56_009325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_009330	COG3829	transcription factor binding
AWH56_009335	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_009340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWH56_009345	COG0506	proline dehydrogenase activity
AWH56_009355	COG2239	Acts as a magnesium transporter
AWH56_009365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_009370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWH56_009375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_009385	COG1937	Protein conserved in bacteria
AWH56_009390	COG0697	spore germination
AWH56_009410	COG3842	ATPase activity
AWH56_009415	COG1840	ABC-type Fe3 transport system, periplasmic component
AWH56_009420	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWH56_009425	COG0705	Rhomboid family
AWH56_009430	COG0736	holo-[acyl-carrier-protein] synthase activity
AWH56_009435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWH56_009435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AWH56_009440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AWH56_009450	COG0864	Transcriptional regulator
AWH56_009455	COG2337	Toxic component of a toxin-antitoxin (TA) module
AWH56_009460	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_009465	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_009470	COG2172	sigma factor antagonist activity
AWH56_009475	COG2208	phosphoserine phosphatase activity
AWH56_009485	COG2172	sigma factor antagonist activity
AWH56_009490	COG1191	sigma factor activity
AWH56_009500	COG2183	response to ionizing radiation
AWH56_009510	COG3091	SprT-like family
AWH56_009655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AWH56_009660	COG0802	atpase or kinase
AWH56_009665	COG1214	PFAM Peptidase M22, glycoprotease
AWH56_009670	COG0456	acetyltransferase
AWH56_009685	COG0488	(ABC) transporter
AWH56_009695	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AWH56_009700	COG2814	Major facilitator Superfamily
AWH56_009705	COG2022	thiamine diphosphate biosynthetic process
AWH56_009720	COG1266	CAAX protease self-immunity
AWH56_009725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AWH56_009730	COG0459	protein refolding
AWH56_009735	COG5577	PFAM Coat F domain
AWH56_009740	COG0714	Associated with various cellular activities
AWH56_009745	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AWH56_009750	COG1305	Transglutaminase-like
AWH56_009755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AWH56_009755	COG0519	Catalyzes the synthesis of GMP from XMP
AWH56_009760	COG2252	PERMEase
AWH56_009800	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWH56_009810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWH56_009815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWH56_009820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWH56_009825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWH56_009830	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWH56_009835	COG0047	phosphoribosylformylglycinamidine synthase activity
AWH56_009840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWH56_009845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWH56_009850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWH56_009855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWH56_009860	COG0138	bifunctional purine biosynthesis protein purh
AWH56_009865	COG0151	Belongs to the GarS family
AWH56_009875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AWH56_009880	COG1470	cell adhesion involved in biofilm formation
AWH56_009885	COG4496	protein, YerC YecD
AWH56_009905	COG0010	Belongs to the arginase family
AWH56_009910	COG1122	ATPase activity
AWH56_009945	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AWH56_009950	COG0210	DNA helicase
AWH56_009955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWH56_009965	COG4851	CamS sex pheromone cAM373 precursor
AWH56_009975	COG1842	Phage shock protein A
AWH56_009980	COG1585	Membrane protein implicated in regulation of membrane protease activity
AWH56_009985	COG2268	Band 7 protein
AWH56_009995	COG0406	alpha-ribazole phosphatase activity
AWH56_010000	COG4129	membrane
AWH56_010005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWH56_010010	COG0154	amidase activity
AWH56_010015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWH56_010020	COG1597	lipid kinase activity
AWH56_010030	COG1595	DNA-templated transcription, initiation
AWH56_010050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWH56_010070	COG0745	RESPONSE REGULATOR receiver
AWH56_010075	COG5002	protein histidine kinase activity
AWH56_010075	COG3850	Histidine kinase
AWH56_010100	COG2340	Cysteine-rich secretory protein family
AWH56_010105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWH56_010130	COG2986	histidine ammonia-lyase
AWH56_010135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AWH56_010140	COG1228	amidohydrolase
AWH56_010145	COG0010	Belongs to the arginase family
AWH56_010160	COG3706	GGDEF domain
AWH56_010175	COG4443	Transcriptional Coactivator p15 (PC4)
AWH56_010200	COG0411	ABC transporter
AWH56_010215	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWH56_010225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_010235	COG2267	carboxylic ester hydrolase activity
AWH56_010240	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_010245	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_010250	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AWH56_010255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWH56_010290	COG1346	cytolysis
AWH56_010335	COG0488	(ABC) transporter
AWH56_010345	COG0523	cobalamin synthesis protein
AWH56_010355	COG0840	transmembrane signaling receptor activity
AWH56_010370	COG1454	alcohol dehydrogenase
AWH56_010370	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_010375	COG0567	Dehydrogenase, E1 component
AWH56_010380	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWH56_010390	COG1595	DNA-templated transcription, initiation
AWH56_010425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_010435	COG0189	ligase activity
AWH56_010445	COG1278	Cold shock
AWH56_010450	COG0477	Major facilitator Superfamily
AWH56_010460	COG3871	stress protein (general stress protein 26)
AWH56_010465	COG2323	membrane
AWH56_010470	COG2364	Membrane
AWH56_010480	COG0535	radical SAM domain protein
AWH56_010510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AWH56_010515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWH56_010520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_010555	COG1253	flavin adenine dinucleotide binding
AWH56_010565	COG4536	flavin adenine dinucleotide binding
AWH56_010575	COG2112	serine threonine protein kinase
AWH56_010595	COG0668	transmembrane transport
AWH56_010610	COG0582	viral genome integration into host DNA
AWH56_010615	COG3263	regulation of cellular component size
AWH56_010625	COG2111	Na H antiporter
AWH56_010625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_010735	COG3266	domain, Protein
AWH56_010735	COG1361	Conserved repeat domain
AWH56_010735	COG2911	Protein conserved in bacteria
AWH56_010830	COG0730	response to heat
AWH56_010835	COG0737	Belongs to the 5'-nucleotidase family
AWH56_010840	COG3377	Domain of unknown function (DUF1805)
AWH56_010850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AWH56_010855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWH56_010865	COG1757	Na H antiporter
AWH56_010870	COG0733	neurotransmitter:sodium symporter activity
AWH56_010880	COG0739	heme binding
AWH56_010885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AWH56_010895	COG4470	Protein conserved in bacteria
AWH56_010910	COG1494	fructose-1,6-bisphosphatase
AWH56_010915	COG2445	Protein of unknown function DUF86
AWH56_010925	COG0647	UMP catabolic process
AWH56_010930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AWH56_010935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AWH56_010940	COG4191	Histidine kinase
AWH56_010945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_010955	COG0460	homoserine dehydrogenase
AWH56_010960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AWH56_010965	COG0083	homoserine kinase activity
AWH56_010970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AWH56_010975	COG4837	Protein of unknown function (DUF1462)
AWH56_010980	COG1252	NADH dehydrogenase
AWH56_010990	COG4844	belongs to the
AWH56_011000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AWH56_011005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AWH56_011015	COG0316	Belongs to the HesB IscA family
AWH56_011020	COG0492	ferredoxin-NADP+ reductase activity
AWH56_011025	COG1252	NADH dehydrogenase
AWH56_011045	COG3584	3D domain protein
AWH56_011050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWH56_011055	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWH56_011060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AWH56_011090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_011095	COG2056	Na+-H+ antiporter family
AWH56_011105	COG1268	BioY protein
AWH56_011320	COG0456	acetyltransferase
AWH56_011335	COG4372	Transposase
AWH56_011425	COG4372	Transposase
AWH56_011485	COG4974	Belongs to the 'phage' integrase family
AWH56_011530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AWH56_011530	COG0456	acetyltransferase
AWH56_011585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_011650	COG1484	DNA-dependent DNA replication
AWH56_011720	COG4372	Transposase
AWH56_011745	COG0494	nUDIX hydrolase
AWH56_011750	COG1595	DNA-templated transcription, initiation
AWH56_011770	COG0456	acetyltransferase
AWH56_011825	COG5646	InterPro IPR014922
AWH56_011835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_011840	COG1131	(ABC) transporter
AWH56_011850	COG1136	(ABC) transporter
AWH56_011855	COG2205	protein histidine kinase activity
AWH56_011860	COG0745	RESPONSE REGULATOR receiver
AWH56_011875	COG2814	Major facilitator Superfamily
AWH56_011910	COG1131	(ABC) transporter
AWH56_011920	COG1404	Belongs to the peptidase S8 family
AWH56_011925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AWH56_011935	COG1131	(ABC) transporter
AWH56_011940	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_011955	COG1854	S-ribosylhomocysteine lyase activity
AWH56_011970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWH56_011975	COG0644	oxidoreductase
AWH56_011985	COG1335	isochorismatase
AWH56_011990	COG1522	sequence-specific DNA binding
AWH56_011995	COG0436	Aminotransferase
AWH56_012005	COG0733	neurotransmitter:sodium symporter activity
AWH56_012015	COG1098	S1 RNA binding domain
AWH56_012020	COG2155	Conserved Protein
AWH56_012025	COG1979	alcohol dehydrogenase
AWH56_012030	COG0166	Belongs to the GPI family
AWH56_012045	COG0640	Transcriptional regulator
AWH56_012050	COG5001	Diguanylate cyclase
AWH56_012050	COG3300	MHYT domain
AWH56_012055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AWH56_012075	COG1802	Transcriptional regulator
AWH56_012080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWH56_012085	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWH56_012090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_012100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_012105	COG1063	alcohol dehydrogenase
AWH56_012110	COG0800	Aldolase
AWH56_012115	COG1312	Catalyzes the dehydration of D-mannonate
AWH56_012120	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_012130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AWH56_012150	COG2972	Histidine kinase
AWH56_012165	COG0673	inositol 2-dehydrogenase activity
AWH56_012195	COG2226	methyltransferase
AWH56_012210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWH56_012235	COG3639	organic phosphonate transmembrane transporter activity
AWH56_012240	COG3639	organic phosphonate transmembrane transporter activity
AWH56_012245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_012255	COG0561	phosphatase activity
AWH56_012290	COG4152	abc transporter atp-binding protein
AWH56_012320	COG0840	transmembrane signaling receptor activity
AWH56_012325	COG3634	alkyl hydroperoxide reductase activity
AWH56_012330	COG0450	alkyl hydroperoxide reductase
AWH56_012335	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_012345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_012350	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_012355	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWH56_012380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_012385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AWH56_012390	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWH56_012400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_012405	COG1484	DNA-dependent DNA replication
AWH56_012415	COG3835	regulator
AWH56_012425	COG3275	phosphorelay sensor kinase activity
AWH56_012440	COG0346	lactoylglutathione lyase activity
AWH56_012445	COG0579	oxidoreductase
AWH56_012450	COG2721	sulfolactate sulfo-lyase activity
AWH56_012475	COG1120	ATPase activity
AWH56_012480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWH56_012485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_012490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_012495	COG1408	metallophosphoesterase
AWH56_012500	COG1368	sulfuric ester hydrolase activity
AWH56_012510	COG1253	flavin adenine dinucleotide binding
AWH56_012520	COG4536	flavin adenine dinucleotide binding
AWH56_012545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_012550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AWH56_012580	COG0470	DNA polymerase III
AWH56_012630	COG4974	Belongs to the 'phage' integrase family
AWH56_012655	COG0582	viral genome integration into host DNA
AWH56_012660	COG4974	Belongs to the 'phage' integrase family
AWH56_012740	COG0398	Pfam SNARE associated Golgi protein
AWH56_012750	COG4134	Bacterial extracellular solute-binding protein
AWH56_012765	COG3842	ATPase activity
AWH56_012775	COG0589	response to stress
AWH56_012805	COG2190	(PTS) system
AWH56_012810	COG3711	transcriptional antiterminator
AWH56_012815	COG1263	PTS System
AWH56_012815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWH56_012820	COG1621	beta-fructofuranosidase activity
AWH56_012830	COG0534	Mate efflux family protein
AWH56_012850	COG1755	Isoprenylcysteine carboxyl methyltransferase
AWH56_012855	COG3424	synthase
AWH56_012860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWH56_012865	COG0129	dihydroxy-acid dehydratase activity
AWH56_012895	COG1070	Carbohydrate kinase
AWH56_012900	COG1737	Transcriptional regulator
AWH56_012905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_012910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_012915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_012915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_012935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_012940	COG0733	neurotransmitter:sodium symporter activity
AWH56_012955	COG0723	plastoquinol--plastocyanin reductase activity
AWH56_012955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWH56_012960	COG0561	phosphatase activity
AWH56_012970	COG0840	transmembrane signaling receptor activity
AWH56_012970	COG3290	protein histidine kinase activity
AWH56_012990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AWH56_013000	COG0243	molybdopterin cofactor binding
AWH56_013005	COG0437	4 iron, 4 sulfur cluster binding
AWH56_013030	COG4585	Histidine kinase
AWH56_013045	COG0175	sulfate reduction
AWH56_013055	COG0306	phosphate transporter
AWH56_013060	COG0529	Catalyzes the synthesis of activated sulfate
AWH56_013085	COG0750	zinc metalloprotease
AWH56_013095	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_013105	COG3829	transcription factor binding
AWH56_013105	COG3290	protein histidine kinase activity
AWH56_013110	COG3829	transcription factor binding
AWH56_013110	COG3290	protein histidine kinase activity
AWH56_013115	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_013120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AWH56_013125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_013130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_013135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWH56_013140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWH56_013145	COG2186	Transcriptional regulator
AWH56_013160	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_013175	COG1506	peptidase
AWH56_013190	COG1725	Transcriptional regulator
AWH56_013195	COG1131	(ABC) transporter
AWH56_013215	COG0697	spore germination
AWH56_013270	COG1164	Oligoendopeptidase f
AWH56_013275	COG1278	Cold shock
AWH56_013280	COG2205	protein histidine kinase activity
AWH56_013285	COG2205	protein histidine kinase activity
AWH56_013295	COG1272	protein, Hemolysin III
AWH56_013320	COG1131	(ABC) transporter
AWH56_013340	COG0586	Pfam SNARE associated Golgi protein
AWH56_013345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AWH56_013350	COG0183	Belongs to the thiolase family
AWH56_013360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AWH56_013370	COG0437	4 iron, 4 sulfur cluster binding
AWH56_013385	COG0746	molybdenum cofactor guanylyltransferase activity
AWH56_013390	COG0303	'Molybdopterin
AWH56_013395	COG0303	'Molybdopterin
AWH56_013405	COG0840	transmembrane signaling receptor activity
AWH56_013405	COG3290	protein histidine kinase activity
AWH56_013415	COG2814	Major facilitator Superfamily
AWH56_013420	COG0494	nUDIX hydrolase
AWH56_013430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWH56_013435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWH56_013440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AWH56_013445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWH56_013450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AWH56_013455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWH56_013460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWH56_013465	COG0297	glycogen (starch) synthase activity
AWH56_013470	COG0058	SHG alpha-glucan phosphorylase activity
AWH56_013485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AWH56_013490	COG2267	carboxylic ester hydrolase activity
AWH56_013505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AWH56_013515	COG0288	reversible hydration of carbon dioxide
AWH56_013520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWH56_013525	COG1242	4 iron, 4 sulfur cluster binding
AWH56_013535	COG2814	Major facilitator Superfamily
AWH56_013540	COG3706	GGDEF domain
AWH56_013545	COG0495	leucyl-tRNA aminoacylation
AWH56_013555	COG2081	HI0933 family
AWH56_013560	COG1414	Transcriptional regulator
AWH56_013565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_013575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_013585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWH56_013590	COG1063	alcohol dehydrogenase
AWH56_013595	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_013600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AWH56_013605	COG0800	Aldolase
AWH56_013610	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_013630	COG2244	polysaccharide biosynthetic process
AWH56_013640	COG0772	Belongs to the SEDS family
AWH56_013645	COG0772	Belongs to the SEDS family
AWH56_013650	COG1187	pseudouridine synthase activity
AWH56_013655	COG1349	DNA-binding transcription factor activity
AWH56_013665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWH56_013685	COG0714	Associated with various cellular activities
AWH56_013690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWH56_013700	COG1380	Effector of murein hydrolase LrgA
AWH56_013705	COG1346	cytolysis
AWH56_013725	COG1523	belongs to the glycosyl hydrolase 13 family
AWH56_013730	COG0510	thiamine kinase activity
AWH56_013755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWH56_013760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_013770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_013775	COG1309	transcriptional regulator
AWH56_013795	COG3290	protein histidine kinase activity
AWH56_013800	COG0494	nUDIX hydrolase
AWH56_013810	COG0217	transcriptional regulatory protein
AWH56_013815	COG0346	lactoylglutathione lyase activity
AWH56_013825	COG2323	membrane
AWH56_013835	COG1363	Peptidase, m42
AWH56_013840	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AWH56_013845	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_013870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_013875	COG1316	TRANSCRIPTIONal
AWH56_013880	COG4848	Belongs to the UPF0354 family
AWH56_013885	COG1674	ftsk spoiiie
AWH56_013900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_013925	COG0668	transmembrane transport
AWH56_013940	COG1595	DNA-templated transcription, initiation
AWH56_013950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWH56_013955	COG2309	aminopeptidase activity
AWH56_013965	COG4980	gas vesicle protein
AWH56_013970	COG3118	belongs to the thioredoxin family
AWH56_013975	COG0849	cell division
AWH56_013980	COG1605	Chorismate mutase
AWH56_013980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWH56_013995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AWH56_014005	COG1846	Transcriptional regulator
AWH56_014010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AWH56_014015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWH56_014020	COG0123	including yeast histone deacetylase and acetoin utilization protein
AWH56_014025	COG0517	IMP dehydrogenase activity
AWH56_014030	COG0454	-acetyltransferase
AWH56_014035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWH56_014055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWH56_014060	COG2199	diguanylate cyclase activity
AWH56_014060	COG2203	Gaf domain
AWH56_014065	COG1309	transcriptional regulator
AWH56_014070	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWH56_014080	COG1104	cysteine desulfurase activity
AWH56_014095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWH56_014100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWH56_014105	COG0616	signal peptide processing
AWH56_014110	COG1714	RDD family
AWH56_014120	COG3874	Sporulation protein YtfJ
AWH56_014125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AWH56_014130	COG0827	DNA restriction-modification system
AWH56_014135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWH56_014140	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_014155	COG0596	Alpha beta hydrolase
AWH56_014160	COG0137	argininosuccinate synthase activity
AWH56_014165	COG0165	Argininosuccinate lyase
AWH56_014170	COG0589	response to stress
AWH56_014180	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_014190	COG0006	proline dipeptidase activity
AWH56_014205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AWH56_014215	COG4109	DRTGG domain
AWH56_014225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_014245	COG0587	DNA-directed DNA polymerase activity
AWH56_014250	COG0281	malic enzyme
AWH56_014255	COG2186	Transcriptional regulator
AWH56_014260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWH56_014265	COG0825	malonyl-CoA metabolic process
AWH56_014270	COG0205	6-phosphofructokinase activity
AWH56_014280	COG3030	protein affecting phage T7 exclusion by the F plasmid
AWH56_014285	COG0840	transmembrane signaling receptor activity
AWH56_014290	COG0628	permease
AWH56_014295	COG2707	UPF0756 membrane protein
AWH56_014300	COG0372	Belongs to the citrate synthase family
AWH56_014305	COG0538	isocitrate dehydrogenase activity
AWH56_014310	COG0039	L-malate dehydrogenase activity
AWH56_014325	COG0745	RESPONSE REGULATOR receiver
AWH56_014330	COG5002	protein histidine kinase activity
AWH56_014335	COG0330	HflC and HflK could
AWH56_014340	COG0330	HflC and HflK could
AWH56_014345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWH56_014345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWH56_014350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWH56_014355	COG1971	Probably functions as a manganese efflux pump
AWH56_014365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWH56_014375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWH56_014380	COG3611	Membrane attachment protein
AWH56_014385	COG1484	DNA-dependent DNA replication
AWH56_014390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AWH56_014400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWH56_014415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWH56_014420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AWH56_014425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWH56_014430	COG3326	Membrane
AWH56_014435	COG0398	Pfam SNARE associated Golgi protein
AWH56_014450	COG1363	Peptidase, m42
AWH56_014465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWH56_014470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWH56_014475	COG0072	phenylalanine-tRNA ligase activity
AWH56_014475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWH56_014485	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWH56_014490	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AWH56_014495	COG1286	toxin biosynthetic process
AWH56_014505	COG1193	negative regulation of DNA recombination
AWH56_014510	COG3766	membrane
AWH56_014520	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_014525	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_014540	COG2010	Cytochrome c
AWH56_014540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_014545	COG3278	Belongs to the heme-copper respiratory oxidase family
AWH56_014550	COG1309	transcriptional regulator
AWH56_014555	COG1024	Enoyl-CoA hydratase
AWH56_014560	COG2086	electron transfer activity
AWH56_014565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWH56_014570	COG3118	belongs to the thioredoxin family
AWH56_014585	COG1719	4-vinyl reductase, 4VR
AWH56_014590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWH56_014595	COG2009	succinate dehydrogenase
AWH56_014600	COG1053	succinate dehydrogenase
AWH56_014605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AWH56_014610	COG0824	Thioesterase
AWH56_014615	COG2197	response regulator
AWH56_014620	COG2031	fatty acid transporter
AWH56_014625	COG1846	Transcriptional regulator
AWH56_014635	COG5401	PFAM Sporulation and spore germination
AWH56_014645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWH56_014650	COG0622	Phosphoesterase
AWH56_014670	COG0129	dihydroxy-acid dehydratase activity
AWH56_014675	COG0028	Belongs to the TPP enzyme family
AWH56_014680	COG0440	acetolactate synthase activity
AWH56_014685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AWH56_014690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWH56_014695	COG0473	3-isopropylmalate dehydrogenase activity
AWH56_014700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AWH56_014705	COG0066	3-isopropylmalate dehydratase activity
AWH56_014710	COG0457	Tetratricopeptide repeat
AWH56_014710	COG1477	protein flavinylation
AWH56_014715	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWH56_014720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWH56_014725	COG1067	ATP-dependent peptidase activity
AWH56_014725	COG0470	DNA polymerase III
AWH56_014730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AWH56_014735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWH56_014750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AWH56_014755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWH56_014760	COG0181	hydroxymethylbilane synthase activity
AWH56_014770	COG0113	porphobilinogen synthase activity
AWH56_014775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AWH56_014780	COG1388	LysM domain
AWH56_014805	COG1136	(ABC) transporter
AWH56_014810	COG0525	valine-tRNA ligase activity
AWH56_014820	COG0285	dihydrofolate synthase activity
AWH56_014825	COG0285	dihydrofolate synthase activity
AWH56_014840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AWH56_014860	COG1027	Aspartate ammonia-lyase
AWH56_014870	COG2003	Belongs to the UPF0758 family
AWH56_014875	COG1077	Cell shape determining protein MreB Mrl
AWH56_014880	COG1792	Involved in formation and maintenance of cell shape
AWH56_014890	COG0850	regulation of cytokinetic process
AWH56_014895	COG2894	cell division
AWH56_014900	COG0483	inositol monophosphate 1-phosphatase activity
AWH56_014910	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_014925	COG0739	heme binding
AWH56_014930	COG1994	Peptidase M50
AWH56_014935	COG1530	ribonuclease E activity
AWH56_014940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWH56_014945	COG2868	ribosomal protein
AWH56_014950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWH56_014955	COG1234	tRNA 3'-trailer cleavage
AWH56_014960	COG0840	transmembrane signaling receptor activity
AWH56_014965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWH56_014970	COG0573	inorganic phosphate transmembrane transporter activity
AWH56_014975	COG0581	inorganic phosphate transmembrane transporter activity
AWH56_014980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWH56_014985	COG0704	Plays a role in the regulation of phosphate uptake
AWH56_014990	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWH56_014995	COG1074	ATP-dependent DNA helicase activity
AWH56_015015	COG5278	phosphoserine phosphatase activity
AWH56_015015	COG0840	transmembrane signaling receptor activity
AWH56_015020	COG0686	Belongs to the AlaDH PNT family
AWH56_015035	COG0840	transmembrane signaling receptor activity
AWH56_015040	COG5001	Diguanylate cyclase
AWH56_015040	COG3300	MHYT domain
AWH56_015070	COG1484	DNA-dependent DNA replication
AWH56_015080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_015090	COG2186	Transcriptional regulator
AWH56_015095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AWH56_015110	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_015130	COG0640	Transcriptional regulator
AWH56_015135	COG0798	PFAM Bile acid sodium symporter
AWH56_015140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWH56_015145	COG2258	MOSC domain
AWH56_015150	COG0439	Biotin carboxylase
AWH56_015155	COG1309	transcriptional regulator
AWH56_015160	COG0511	ligase activity, forming carbon-carbon bonds
AWH56_015165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AWH56_015170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_015170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_015175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_015175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_015180	COG1703	isobutyryl-CoA mutase activity
AWH56_015215	COG4372	Transposase
AWH56_015220	COG0785	Cytochrome C biogenesis protein
AWH56_015235	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_015240	COG0840	transmembrane signaling receptor activity
AWH56_015245	COG0501	Belongs to the peptidase M48B family
AWH56_015270	COG0393	Putative heavy-metal-binding
AWH56_015285	COG0534	Mate efflux family protein
AWH56_015290	COG2207	Transcriptional regulator
AWH56_015290	COG1917	Cupin 2, conserved barrel domain protein
AWH56_015300	COG2182	Extracellular solute-binding protein
AWH56_015305	COG1175	transmembrane transport
AWH56_015310	COG3833	ABC-type maltose transport systems, permease component
AWH56_015325	COG0628	permease
AWH56_015330	COG0205	6-phosphofructokinase activity
AWH56_015335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_015345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_015360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWH56_015375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWH56_015400	COG1858	cytochrome C peroxidase
AWH56_015420	COG0561	phosphatase activity
AWH56_015430	COG3336	cytochrome c oxidase
AWH56_015445	COG0303	'Molybdopterin
AWH56_015450	COG1763	Mo-molybdopterin cofactor biosynthetic process
AWH56_015455	COG0314	molybdopterin synthase activity
AWH56_015460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AWH56_015465	COG2151	metal-sulfur cluster biosynthetic enzyme
AWH56_015480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWH56_015485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWH56_015490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AWH56_015500	COG0505	Belongs to the CarA family
AWH56_015505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWH56_015510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWH56_015515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_015525	COG0535	radical SAM domain protein
AWH56_015535	COG0243	molybdopterin cofactor binding
AWH56_015540	COG0437	4 iron, 4 sulfur cluster binding
AWH56_015555	COG2223	nitrite transmembrane transporter activity
AWH56_015560	COG2223	nitrite transmembrane transporter activity
AWH56_015565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_015585	COG2267	carboxylic ester hydrolase activity
AWH56_015590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_015600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWH56_015605	COG1744	ABC transporter substrate-binding protein PnrA-like
AWH56_015620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_015625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWH56_015635	COG4758	membrane
AWH56_015640	COG4585	Histidine kinase
AWH56_015645	COG2197	response regulator
AWH56_015650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_015655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWH56_015660	COG5504	Zn-dependent protease
AWH56_015675	COG0180	Tryptophanyl-tRNA synthetase
AWH56_015685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_015690	COG1418	mRNA catabolic process
AWH56_015695	COG0166	Belongs to the GPI family
AWH56_015705	COG0456	acetyltransferase
AWH56_015720	COG1393	Belongs to the ArsC family
AWH56_015725	COG0861	Integral membrane protein TerC family
AWH56_015730	COG4862	establishment of competence for transformation
AWH56_015735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWH56_015740	COG4469	Competence protein
AWH56_015745	COG1164	Oligoendopeptidase f
AWH56_015750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWH56_015755	COG2346	COG2346, Truncated hemoglobins
AWH56_015760	COG0741	lytic transglycosylase activity
AWH56_015765	COG4116	CYTH
AWH56_015775	COG2357	RelA SpoT domain protein
AWH56_015780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWH56_015785	COG0564	pseudouridine synthase activity
AWH56_015795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AWH56_015805	COG0475	glutathione-regulated potassium exporter activity
AWH56_015805	COG0589	response to stress
AWH56_015825	COG1216	Glycosyl transferase, family 2
AWH56_015870	COG0463	Glycosyl transferase, family 2
AWH56_015870	COG0457	Tetratricopeptide repeat
AWH56_015880	COG0463	Glycosyl transferase, family 2
AWH56_015920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_015925	COG0673	inositol 2-dehydrogenase activity
AWH56_015935	COG4641	Protein conserved in bacteria
AWH56_015935	COG1388	LysM domain
AWH56_015955	COG0210	DNA helicase
AWH56_015970	COG2153	protein acetylation
AWH56_015975	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AWH56_015980	COG2382	esterase
AWH56_015990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AWH56_016010	COG4974	Belongs to the 'phage' integrase family
AWH56_016050	COG1609	Transcriptional regulator
AWH56_016055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_016060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_016060	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_016065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_016065	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_016070	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWH56_016080	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_016085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AWH56_016090	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_016095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_016160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_016165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AWH56_016170	COG5001	Diguanylate cyclase
AWH56_016200	COG1131	(ABC) transporter
AWH56_016215	COG0535	radical SAM domain protein
AWH56_016230	COG4999	Histidine kinase
AWH56_016230	COG3850	Histidine kinase
AWH56_016230	COG3437	response regulator, receiver
AWH56_016230	COG2205	protein histidine kinase activity
AWH56_016235	COG5002	protein histidine kinase activity
AWH56_016235	COG0784	Response regulator, receiver
AWH56_016240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AWH56_016245	COG5002	protein histidine kinase activity
AWH56_016250	COG0778	Nitroreductase
AWH56_016280	COG0071	Belongs to the small heat shock protein (HSP20) family
AWH56_016295	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWH56_016330	COG0589	response to stress
AWH56_016335	COG0668	transmembrane transport
AWH56_016355	COG2224	Isocitrate lyase
AWH56_016360	COG2171	N-acyltransferase activity
AWH56_016365	COG1473	amidohydrolase
AWH56_016375	COG0668	transmembrane transport
AWH56_016380	COG0450	alkyl hydroperoxide reductase
AWH56_016385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_016405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWH56_016435	COG0022	dehydrogenase e1 component
AWH56_016440	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWH56_016450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_016455	COG4129	membrane
AWH56_016460	COG0726	polysaccharide deacetylase
AWH56_016490	COG1982	Orn Lys Arg decarboxylase major
AWH56_016495	COG4476	Belongs to the UPF0223 family
AWH56_016500	COG4493	Belongs to the UPF0637 family
AWH56_016510	COG0483	inositol monophosphate 1-phosphatase activity
AWH56_016520	COG1217	gtp-binding protein TYPA
AWH56_016530	COG4896	Protein conserved in bacteria
AWH56_016545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AWH56_016550	COG2066	Belongs to the glutaminase family
AWH56_016555	COG4838	Belongs to the UPF0358 family
AWH56_016565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWH56_016570	COG1612	heme a metabolic process
AWH56_016575	COG0109	protoheme IX farnesyltransferase activity
AWH56_016580	COG2010	Cytochrome c
AWH56_016580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_016590	COG1845	cytochrome c oxidase, subunit III
AWH56_016595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AWH56_016605	COG0628	permease
AWH56_016620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWH56_016625	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AWH56_016630	COG2340	Cysteine-rich secretory protein family
AWH56_016665	COG4294	response to UV
AWH56_016670	COG3679	Belongs to the UPF0342 family
AWH56_016675	COG4471	UPF0298 protein
AWH56_016685	COG0742	ribosomal rna small subunit methyltransferase
AWH56_016690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWH56_016695	COG3314	Sporulation integral membrane protein YlbJ
AWH56_016700	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWH56_016705	COG3480	Lon protease (S16) C-terminal proteolytic domain
AWH56_016710	COG1323	Belongs to the UPF0348 family
AWH56_016715	COG1399	metal-binding, possibly nucleic acid-binding protein
AWH56_016720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AWH56_016725	COG1024	Enoyl-CoA hydratase
AWH56_016735	COG0454	-acetyltransferase
AWH56_016740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AWH56_016755	COG2001	Belongs to the MraZ family
AWH56_016760	COG0275	rRNA processing
AWH56_016770	COG0768	penicillin binding
AWH56_016775	COG0768	penicillin binding
AWH56_016780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWH56_016785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWH56_016790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWH56_016800	COG0772	Belongs to the SEDS family
AWH56_016805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWH56_016810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWH56_016815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWH56_016820	COG3879	Bacterial protein of unknown function (DUF881)
AWH56_016830	COG3856	small basic protein
AWH56_016835	COG0849	cell division
AWH56_016840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWH56_016850	COG1191	sigma factor activity
AWH56_016855	COG1191	sigma factor activity
AWH56_016860	COG1873	PFAM PRC-barrel domain
AWH56_016865	COG1496	oxidoreductase activity
AWH56_016870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWH56_016875	COG1799	cell septum assembly
AWH56_016880	COG0762	integral membrane protein
AWH56_016885	COG2302	S4 RNA-binding domain
AWH56_016890	COG3599	regulation of cell shape
AWH56_016895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWH56_016900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AWH56_016910	COG0564	pseudouridine synthase activity
AWH56_016915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AWH56_016925	COG0540	Belongs to the ATCase OTCase family
AWH56_016930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWH56_016940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWH56_016950	COG0167	dihydroorotate dehydrogenase activity
AWH56_016960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWH56_016970	COG1132	(ABC) transporter
AWH56_016975	COG1132	(ABC) transporter
AWH56_016985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWH56_016990	COG1561	YicC-like family, N-terminal region
AWH56_016995	COG2052	Domain of unknown function (DUF370)
AWH56_017000	COG0194	GDP metabolic process
AWH56_017005	COG1758	RNA polymerase activity
AWH56_017010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWH56_017015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWH56_017025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWH56_017030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWH56_017030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWH56_017035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWH56_017040	COG0631	protein serine/threonine phosphatase activity
AWH56_017045	COG0515	serine threonine protein kinase
AWH56_017045	COG2815	serine threonine protein kinase
AWH56_017050	COG1162	GTPase activity
AWH56_017055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWH56_017060	COG3859	Proton-coupled thiamine transporter YuaJ
AWH56_017065	COG1564	THIamine pyrophosphokinase
AWH56_017075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWH56_017080	COG1302	Protein conserved in bacteria
AWH56_017085	COG1461	Dihydroxyacetone kinase
AWH56_017090	COG1307	EDD domain protein, DegV family
AWH56_017095	COG1760	l-serine dehydratase
AWH56_017100	COG1760	l-serine dehydratase
AWH56_017105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWH56_017110	COG1349	DNA-binding transcription factor activity
AWH56_017120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWH56_017125	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_017130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWH56_017135	COG0571	ribonuclease III activity
AWH56_017140	COG4840	Belongs to the UPF0435 family
AWH56_017145	COG1196	nuclear chromosome segregation
AWH56_017150	COG0552	protein localization to endoplasmic reticulum
AWH56_017155	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AWH56_017160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWH56_017165	COG0228	four-way junction DNA binding
AWH56_017170	COG1837	Belongs to the UPF0109 family
AWH56_017190	COG0335	large ribosomal subunit rRNA binding
AWH56_017215	COG2257	FlhB HrpN YscU SpaS Family
AWH56_017230	COG0045	succinate-CoA ligase (ADP-forming) activity
AWH56_017235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AWH56_017240	COG0758	DNA mediated transformation
AWH56_017245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWH56_017250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AWH56_017255	COG4974	Belongs to the 'phage' integrase family
AWH56_017260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AWH56_017265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AWH56_017270	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AWH56_017275	COG1815	bacterial-type flagellum-dependent cell motility
AWH56_017280	COG1558	bacterial-type flagellum-dependent cell motility
AWH56_017285	COG1677	Flagellar hook-basal body complex protein FliE
AWH56_017290	COG1766	The M ring may be actively involved in energy transduction
AWH56_017295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWH56_017300	COG1317	bacterial-type flagellum organization
AWH56_017305	COG1157	protein secretion by the type III secretion system
AWH56_017325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AWH56_017340	COG1582	Flagellar protein (FlbD)
AWH56_017345	COG1580	Controls the rotational direction of flagella during chemotaxis
AWH56_017350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWH56_017355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWH56_017355	COG1776	CheC inhibitor of MCP methylation
AWH56_017360	COG2201	protein-glutamate methylesterase activity
AWH56_017365	COG3190	flagellar
AWH56_017370	COG1338	Plays a role in the flagellum-specific transport system
AWH56_017375	COG1987	bacterial-type flagellum assembly
AWH56_017380	COG1684	flagellar biosynthetic protein fliR
AWH56_017385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWH56_017405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWH56_017410	COG1419	protein localization to endoplasmic reticulum
AWH56_017415	COG0455	bacterial-type flagellum organization
AWH56_017420	COG2201	protein-glutamate methylesterase activity
AWH56_017425	COG2198	Histidine kinase
AWH56_017425	COG0643	Histidine kinase
AWH56_017430	COG0835	chemotaxis
AWH56_017435	COG1776	CheC inhibitor of MCP methylation
AWH56_017440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AWH56_017450	COG1191	sigma factor activity
AWH56_017470	COG0052	Belongs to the universal ribosomal protein uS2 family
AWH56_017475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWH56_017480	COG0528	UMP kinase activity
AWH56_017485	COG0233	cytoplasmic translational termination
AWH56_017490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWH56_017495	COG4589	Belongs to the CDS family
AWH56_017500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AWH56_017505	COG0750	zinc metalloprotease
AWH56_017520	COG2176	DNA-directed DNA polymerase activity
AWH56_017525	COG0779	Required for maturation of 30S ribosomal subunits
AWH56_017530	COG0195	Participates in both transcription termination and antitermination
AWH56_017535	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWH56_017540	COG1358	cellular component organization or biogenesis
AWH56_017545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AWH56_017555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWH56_017565	COG0196	riboflavin kinase activity
AWH56_017570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWH56_017575	COG1185	polyribonucleotide nucleotidyltransferase activity
AWH56_017580	COG0726	polysaccharide deacetylase
AWH56_017585	COG0612	Peptidase, M16
AWH56_017590	COG1873	PFAM PRC-barrel domain
AWH56_017595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_017600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWH56_017605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWH56_017610	COG0527	aspartate kinase activity
AWH56_017620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWH56_017625	COG0740	serine-type endopeptidase activity
AWH56_017635	COG1674	ftsk spoiiie
AWH56_017640	COG2188	Transcriptional regulator
AWH56_017645	COG0612	Peptidase, M16
AWH56_017650	COG0612	Peptidase, M16
AWH56_017655	COG0300	oxidoreductase activity
AWH56_017670	COG1426	Protein conserved in bacteria
AWH56_017675	COG1666	GTP binding
AWH56_017680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWH56_017685	COG1546	Belongs to the CinA family
AWH56_017685	COG1058	Belongs to the CinA family
AWH56_017690	COG0513	Belongs to the DEAD box helicase family
AWH56_017695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWH56_017700	COG1418	mRNA catabolic process
AWH56_017705	COG1692	metallophosphoesterase
AWH56_017710	COG2359	stage V sporulation protein S
AWH56_017715	COG0674	pyruvate-flavodoxin oxidoreductase activity
AWH56_017715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AWH56_017720	COG1013	pyruvate-flavodoxin oxidoreductase activity
AWH56_017725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWH56_017730	COG4550	Control of competence regulator ComK, YlbF/YmcA
AWH56_017745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWH56_017750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWH56_017755	COG2521	methyltransferase
AWH56_017755	COG2136	Putative SAM-dependent methyltransferase
AWH56_017760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWH56_017765	COG1923	regulation of RNA biosynthetic process
AWH56_017775	COG0464	growth
AWH56_017780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWH56_017785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AWH56_017790	COG0789	Transcriptional regulator
AWH56_017795	COG0174	glutamine synthetase
AWH56_017800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWH56_017810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_017815	COG4224	UPF0291 protein
AWH56_017820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AWH56_017830	COG3763	UPF0154 protein
AWH56_017835	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AWH56_017840	COG1132	(ABC) transporter
AWH56_017845	COG1132	(ABC) transporter
AWH56_017850	COG1937	Protein conserved in bacteria
AWH56_017855	COG2217	Heavy metal translocating P-type atpase
AWH56_017865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_017875	COG4846	Membrane protein involved in cytochrome C biogenesis
AWH56_017885	COG0626	cystathionine gamma-synthase activity
AWH56_017890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWH56_017895	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AWH56_017900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWH56_017930	COG2223	nitrite transmembrane transporter activity
AWH56_017935	COG3773	Cell wall hydrolase
AWH56_017975	COG0733	neurotransmitter:sodium symporter activity
AWH56_017985	COG2169	Transcriptional regulator
AWH56_017990	COG0697	spore germination
AWH56_018005	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_018015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_018030	COG0154	amidase activity
AWH56_018070	COG1414	Transcriptional regulator
AWH56_018075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWH56_018165	COG1484	DNA-dependent DNA replication
AWH56_018195	COG1695	Transcriptional regulator
AWH56_018450	COG0456	acetyltransferase
AWH56_018450	COG1214	PFAM Peptidase M22, glycoprotease
AWH56_018470	COG1484	DNA-dependent DNA replication
AWH56_018530	COG4974	Belongs to the 'phage' integrase family
AWH56_018535	COG0582	viral genome integration into host DNA
AWH56_018540	COG4974	Belongs to the 'phage' integrase family
AWH56_018595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_018680	COG1595	DNA-templated transcription, initiation
AWH56_018745	COG4372	Transposase
AWH56_018765	COG1247	-acetyltransferase
AWH56_018820	COG4974	Belongs to the 'phage' integrase family
AWH56_018825	COG0582	viral genome integration into host DNA
AWH56_018830	COG4974	Belongs to the 'phage' integrase family
AWH56_018925	COG1160	GTP binding
AWH56_018960	COG1253	flavin adenine dinucleotide binding
AWH56_018975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWH56_018975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_019015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AWH56_019030	COG2323	membrane
AWH56_019050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AWH56_019060	COG0398	Pfam SNARE associated Golgi protein
AWH56_019085	COG0464	growth
AWH56_019090	COG0824	Thioesterase
AWH56_019100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AWH56_019105	COG0613	PHP domain protein
AWH56_019110	COG0328	RNA-DNA hybrid ribonuclease activity
AWH56_019115	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AWH56_019125	COG1924	4 iron, 4 sulfur cluster binding
AWH56_019140	COG2200	EAL domain
AWH56_019150	COG1704	LemA family
AWH56_019160	COG0840	transmembrane signaling receptor activity
AWH56_019160	COG3290	protein histidine kinase activity
AWH56_019190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWH56_019200	COG1131	(ABC) transporter
AWH56_019205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_019210	COG1725	Transcriptional regulator
AWH56_019215	COG1131	(ABC) transporter
AWH56_019230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWH56_019240	COG0835	chemotaxis
AWH56_019240	COG0784	Response regulator, receiver
AWH56_019250	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWH56_019255	COG1151	hydroxylamine reductase activity
AWH56_019265	COG0674	pyruvate-flavodoxin oxidoreductase activity
AWH56_019270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AWH56_019275	COG1418	mRNA catabolic process
AWH56_019280	COG1388	LysM domain
AWH56_019280	COG0791	NLP P60 protein
AWH56_019290	COG2814	Major facilitator Superfamily
AWH56_019335	COG0697	spore germination
AWH56_019350	COG3852	Histidine kinase
AWH56_019365	COG1111	helicase
AWH56_019365	COG1205	dead DEAH box helicase
AWH56_019370	COG3359	exonuclease
AWH56_019375	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AWH56_019380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_019380	COG0617	tRNA 3'-terminal CCA addition
AWH56_019380	COG0517	IMP dehydrogenase activity
AWH56_019385	COG2176	DNA-directed DNA polymerase activity
AWH56_019400	COG4474	Belongs to the UPF0398 family
AWH56_019405	COG3599	regulation of cell shape
AWH56_019410	COG0328	RNA-DNA hybrid ribonuclease activity
AWH56_019420	COG0116	Belongs to the methyltransferase superfamily
AWH56_019435	COG1199	ATP-dependent helicase activity
AWH56_019445	COG2030	dehydratase
AWH56_019470	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_019485	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AWH56_019490	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AWH56_019495	COG4585	Histidine kinase
AWH56_019500	COG2197	response regulator
AWH56_019510	COG1131	(ABC) transporter
AWH56_019515	COG1511	domain protein
AWH56_019515	COG0842	Transport permease protein
AWH56_019525	COG2843	Capsule synthesis protein
AWH56_019530	COG0584	glycerophosphoryl diester phosphodiesterase
AWH56_019535	COG0183	Belongs to the thiolase family
AWH56_019545	COG0183	Belongs to the thiolase family
AWH56_019550	COG3858	chitin binding
AWH56_019555	COG1832	CoA-binding protein
AWH56_019560	COG0187	DNA topoisomerase II activity
AWH56_019565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWH56_019570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_019600	COG1086	Polysaccharide biosynthesis protein
AWH56_019605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWH56_019610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWH56_019615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AWH56_019625	COG0728	peptidoglycan biosynthetic process
AWH56_019630	COG5039	Polysaccharide pyruvyl transferase
AWH56_019635	COG3944	biosynthesis protein
AWH56_019640	COG0489	protein tyrosine kinase activity
AWH56_019645	COG0438	transferase activity, transferring glycosyl groups
AWH56_019665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWH56_019670	COG4974	Belongs to the 'phage' integrase family
AWH56_019675	COG0501	Belongs to the peptidase M48B family
AWH56_019680	COG1714	RDD family
AWH56_019690	COG2133	pyrroloquinoline quinone binding
AWH56_019695	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_019700	COG3340	Belongs to the peptidase S51 family
AWH56_019705	COG1595	DNA-templated transcription, initiation
AWH56_019735	COG0583	DNA-binding transcription factor activity
AWH56_019760	COG1090	epimerase
AWH56_019765	COG0673	inositol 2-dehydrogenase activity
AWH56_019770	COG1164	Oligoendopeptidase f
AWH56_019780	COG1231	oxidoreductase activity
AWH56_019805	COG1285	pathogenesis
AWH56_019810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_019810	COG2199	diguanylate cyclase activity
AWH56_019825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWH56_019840	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_019845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AWH56_019850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWH56_019855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWH56_019860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWH56_019865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AWH56_019880	COG1509	lysine 2,3-aminomutase activity
AWH56_019885	COG3829	transcription factor binding
AWH56_019915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AWH56_019920	COG0456	acetyltransferase
AWH56_019930	COG3695	enzyme binding
AWH56_019935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWH56_019940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_019950	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_019960	COG2322	membrane
AWH56_019975	COG3852	Histidine kinase
AWH56_020005	COG1413	lyase activity
AWH56_020020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_020080	COG2094	Belongs to the DNA glycosylase MPG family
AWH56_020090	COG0546	phosphoglycolate phosphatase activity
AWH56_020170	COG0739	heme binding
AWH56_020170	COG1196	nuclear chromosome segregation
AWH56_020170	COG0741	lytic transglycosylase activity
AWH56_020195	COG1757	Na H antiporter
AWH56_020200	COG0791	NLP P60 protein
AWH56_020200	COG1388	LysM domain
AWH56_020215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_020220	COG1131	(ABC) transporter
AWH56_020225	COG2755	lipolytic protein G-D-S-L family
AWH56_020250	COG1388	LysM domain
AWH56_020250	COG3858	chitin binding
AWH56_020260	COG5001	Diguanylate cyclase
AWH56_020265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWH56_020270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWH56_020275	COG1116	anion transmembrane transporter activity
AWH56_020280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AWH56_020295	COG2720	vancomycin resistance protein
AWH56_020325	COG3192	ethanolamine utilization protein
AWH56_020340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AWH56_020355	COG0861	Integral membrane protein TerC family
AWH56_020420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWH56_020425	COG0569	domain protein
AWH56_020440	COG0312	modulator of DNA gyrase
AWH56_020445	COG0312	modulator of DNA gyrase
AWH56_020450	COG3180	Ammonia monooxygenase
AWH56_020460	COG0385	Bile acid
AWH56_020470	COG1959	2 iron, 2 sulfur cluster binding
AWH56_020495	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AWH56_020550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWH56_020575	COG1131	(ABC) transporter
AWH56_020580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AWH56_020655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWH56_020675	COG4555	ABC transporter
AWH56_020685	COG1595	DNA-templated transcription, initiation
AWH56_020730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AWH56_020770	COG1484	DNA-dependent DNA replication
AWH56_020795	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AWH56_020795	COG0028	Belongs to the TPP enzyme family
AWH56_020890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWH56_020895	COG1278	Cold shock
AWH56_020915	COG0477	Major facilitator Superfamily
AWH56_020920	COG0584	glycerophosphoryl diester phosphodiesterase
AWH56_020980	COG1363	Peptidase, m42
AWH56_020990	COG2362	D-Aminopeptidase
AWH56_020995	COG2201	protein-glutamate methylesterase activity
AWH56_021000	COG3852	Histidine kinase
AWH56_021010	COG0444	Belongs to the ABC transporter superfamily
AWH56_021020	COG0601	transmembrane transport
AWH56_021025	COG0747	negative chemotaxis
AWH56_021035	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AWH56_021045	COG1764	response to oxidative stress
AWH56_021060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_021070	COG0489	protein tyrosine kinase activity
AWH56_021090	COG0437	4 iron, 4 sulfur cluster binding
AWH56_021095	COG0243	molybdopterin cofactor binding
AWH56_021105	COG1295	ribonuclease BN
AWH56_021130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AWH56_021140	COG2154	pterin-4-alpha-carbinolamine dehydratase
AWH56_021145	COG3186	Phenylalanine-4-hydroxylase
AWH56_021150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AWH56_021150	COG2885	chlorophyll binding
AWH56_021170	COG1192	Involved in chromosome partitioning
AWH56_021180	COG2311	Membrane
AWH56_021190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_021235	COG1199	ATP-dependent helicase activity
AWH56_021235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWH56_021250	COG0667	Aldo Keto reductase
AWH56_021255	COG1999	signal sequence binding
AWH56_021295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_021310	COG4948	Mandelate Racemase Muconate Lactonizing
AWH56_021320	COG3314	Sporulation integral membrane protein YlbJ
AWH56_021350	COG3012	SEC-C Motif Domain Protein
AWH56_021355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_021365	COG1132	(ABC) transporter
AWH56_021400	COG0534	Mate efflux family protein
AWH56_021455	COG0577	efflux transmembrane transporter activity
AWH56_021485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWH56_021495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWH56_021520	COG1472	Belongs to the glycosyl hydrolase 3 family
AWH56_021540	COG0562	UDP-galactopyranose mutase
AWH56_021560	COG1136	(ABC) transporter
AWH56_021595	COG1846	Transcriptional regulator
AWH56_021595	COG0456	acetyltransferase
AWH56_021605	COG0534	Mate efflux family protein
AWH56_021645	COG3655	Transcriptional regulator
AWH56_021670	COG2207	Transcriptional regulator
AWH56_021670	COG3708	Transcriptional regulator
AWH56_021680	COG1556	Lactate utilization protein
AWH56_021685	COG1139	Iron-sulfur cluster binding protein
AWH56_021690	COG0247	lactate metabolic process
AWH56_021710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWH56_021715	COG0583	DNA-binding transcription factor activity
AWH56_021725	COG1811	Na channel or pump
AWH56_021730	COG4978	Transcriptional regulator
AWH56_021730	COG0789	Transcriptional regulator
AWH56_021740	COG2514	catechol 2,3-dioxygenase activity
AWH56_021745	COG2259	Doxx family
AWH56_021760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_021760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_021765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_021790	COG3708	Transcriptional regulator
AWH56_021790	COG2207	Transcriptional regulator
AWH56_021840	COG1061	Type III restriction enzyme res subunit
AWH56_021850	COG0537	adenosine 5'-monophosphoramidase activity
AWH56_021855	COG1201	RNA secondary structure unwinding
AWH56_021870	COG1061	Type III restriction enzyme res subunit
AWH56_021875	COG2807	transmembrane transport
AWH56_021880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_021885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_021890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_021980	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWH56_021985	COG5001	Diguanylate cyclase
AWH56_021985	COG3300	MHYT domain
AWH56_022025	COG2197	response regulator
AWH56_022035	COG4585	Histidine kinase
AWH56_022040	COG1131	(ABC) transporter
AWH56_022120	COG3012	SEC-C Motif Domain Protein
AWH56_022130	COG5002	protein histidine kinase activity
AWH56_022150	COG3339	Conserved Protein
AWH56_022175	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWH56_022185	COG2610	gluconate transmembrane transporter activity
AWH56_022195	COG2084	Dehydrogenase
AWH56_022200	COG1802	Transcriptional regulator
AWH56_022205	COG1505	serine-type exopeptidase activity
AWH56_022235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWH56_022255	COG0604	alcohol dehydrogenase
AWH56_022275	COG2814	Major facilitator Superfamily
AWH56_022280	COG0823	Involved in the tonB-independent uptake of proteins
AWH56_022280	COG4946	Tricorn protease homolog
AWH56_022280	COG1506	peptidase
AWH56_022290	COG3655	Transcriptional regulator
AWH56_022305	COG0861	Integral membrane protein TerC family
AWH56_022320	COG1668	transmembrane transport
AWH56_022325	COG4152	abc transporter atp-binding protein
AWH56_022340	COG0563	adenylate kinase activity
AWH56_022470	COG5002	protein histidine kinase activity
AWH56_022490	COG1307	EDD domain protein, DegV family
AWH56_022495	COG1132	(ABC) transporter
AWH56_022505	COG5002	protein histidine kinase activity
AWH56_022510	COG5002	protein histidine kinase activity
AWH56_022520	COG0516	GMP reductase activity
AWH56_022530	COG1725	Transcriptional regulator
AWH56_022535	COG1131	(ABC) transporter
AWH56_022550	COG3739	integral membrane protein
AWH56_022555	COG0697	spore germination
AWH56_022560	COG1966	Carbon starvation protein
AWH56_022575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWH56_022585	COG0501	Belongs to the peptidase M48B family
AWH56_022595	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AWH56_022600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AWH56_022650	COG0840	transmembrane signaling receptor activity
AWH56_022655	COG2323	membrane
AWH56_022690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_022710	COG1228	amidohydrolase
AWH56_022745	COG0436	Aminotransferase
AWH56_022750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWH56_022795	COG1272	protein, Hemolysin III
AWH56_022810	COG1408	metallophosphoesterase
AWH56_022840	COG2514	catechol 2,3-dioxygenase activity
AWH56_022855	COG0697	spore germination
AWH56_022860	COG1114	Component of the transport system for branched-chain amino acids
AWH56_022870	COG2323	membrane
AWH56_022890	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_022925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AWH56_022935	COG3832	glyoxalase III activity
AWH56_022940	COG1664	Polymer-forming cytoskeletal
AWH56_022945	COG0789	Transcriptional regulator
AWH56_022955	COG1113	amino acid transport
AWH56_022960	COG1280	lysine exporter protein (LysE YggA)
AWH56_022985	COG0456	acetyltransferase
AWH56_023000	COG0662	Cupin 2, conserved barrel domain protein
AWH56_023005	COG1714	RDD family
AWH56_023020	COG2135	peptidase activity
AWH56_023035	COG3546	catalase activity
AWH56_023050	COG0473	3-isopropylmalate dehydrogenase activity
AWH56_023055	COG3559	Exporter of polyketide antibiotics
AWH56_023060	COG1131	(ABC) transporter
AWH56_023065	COG2860	membrane
AWH56_023150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_023185	COG1309	transcriptional regulator
AWH56_023210	COG2244	polysaccharide biosynthetic process
AWH56_023215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AWH56_023220	COG1846	Transcriptional regulator
AWH56_023230	COG0681	Belongs to the peptidase S26 family
AWH56_023265	COG1595	DNA-templated transcription, initiation
AWH56_023280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_023290	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_023295	COG0604	alcohol dehydrogenase
AWH56_023295	COG4221	oxidoreductase activity
AWH56_023295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AWH56_023295	COG3321	synthase
AWH56_023310	COG3852	Histidine kinase
AWH56_023330	COG0243	molybdopterin cofactor binding
AWH56_023335	COG0697	spore germination
AWH56_023340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWH56_023345	COG0708	Exodeoxyribonuclease III
AWH56_023360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWH56_023370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AWH56_023380	COG0656	L-ascorbic acid biosynthetic process
AWH56_023400	COG1231	oxidoreductase activity
AWH56_023415	COG4895	conserved protein (DUF2196)
AWH56_023425	COG1587	Uroporphyrinogen-III synthase
AWH56_023435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWH56_023445	COG4608	Belongs to the ABC transporter superfamily
AWH56_023450	COG0444	Belongs to the ABC transporter superfamily
AWH56_023455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_023460	COG0601	transmembrane transport
AWH56_023485	COG1063	alcohol dehydrogenase
AWH56_023490	COG1960	acyl-CoA dehydrogenase activity
AWH56_023500	COG0693	protein deglycase activity
AWH56_023505	COG5522	Integral membrane protein (intg_mem_TP0381)
AWH56_023510	COG0789	Transcriptional regulator
AWH56_023515	COG2176	DNA-directed DNA polymerase activity
AWH56_023525	COG0004	ammonium transporteR
AWH56_023545	COG1329	Transcriptional regulator
AWH56_023550	COG0583	DNA-binding transcription factor activity
AWH56_023555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWH56_023560	COG2340	Cysteine-rich secretory protein family
AWH56_023585	COG2153	protein acetylation
AWH56_023590	COG1132	(ABC) transporter
AWH56_023595	COG1132	(ABC) transporter
AWH56_023620	COG3437	response regulator, receiver
AWH56_023625	COG0277	FAD linked oxidase domain protein
AWH56_023630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWH56_023635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AWH56_023655	COG1393	Belongs to the ArsC family
AWH56_023660	COG5002	protein histidine kinase activity
AWH56_023660	COG3850	Histidine kinase
AWH56_023665	COG0745	RESPONSE REGULATOR receiver
AWH56_023670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWH56_023675	COG0398	Pfam SNARE associated Golgi protein
AWH56_023710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWH56_023735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AWH56_023740	COG0583	DNA-binding transcription factor activity
AWH56_023745	COG2814	Major facilitator Superfamily
AWH56_023750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWH56_023755	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_023765	COG1469	GTP cyclohydrolase I activity
AWH56_023770	COG2070	2-Nitropropane dioxygenase
AWH56_023785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWH56_023790	COG2223	nitrite transmembrane transporter activity
AWH56_023805	COG3830	Belongs to the UPF0237 family
AWH56_023880	COG1033	growth of symbiont in host cell
AWH56_023880	COG2409	Drug exporters of the RND superfamily
AWH56_023890	COG2962	Rard protein
AWH56_023915	COG0488	(ABC) transporter
AWH56_023920	COG0488	(ABC) transporter
AWH56_023940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_023955	COG0826	peptidase U32
AWH56_023965	COG1942	4-Oxalocrotonate Tautomerase
AWH56_023970	COG0477	Major facilitator Superfamily
AWH56_023980	COG0702	epimerase
AWH56_024005	COG5609	conserved protein (DUF2294)
AWH56_024015	COG3546	catalase activity
AWH56_024035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AWH56_024035	COG1587	Uroporphyrinogen-III synthase
AWH56_024045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AWH56_024050	COG0436	Aminotransferase
AWH56_024070	COG2309	aminopeptidase activity
AWH56_024095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AWH56_024100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_024110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AWH56_024115	COG1984	allophanate hydrolase subunit 2
AWH56_024120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AWH56_024125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWH56_024130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWH56_024135	COG0419	ATPase involved in DNA repair
AWH56_024195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWH56_024225	COG1555	photosystem II stabilization
AWH56_024225	COG1596	polysaccharide export
AWH56_024230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWH56_024230	COG0574	Belongs to the PEP-utilizing enzyme family
AWH56_024240	COG2814	Major facilitator Superfamily
AWH56_024275	COG3383	formate dehydrogenase (NAD+) activity
AWH56_024315	COG1428	Deoxynucleoside kinase
AWH56_024320	COG1428	Deoxynucleoside kinase
AWH56_024325	COG0514	ATP-dependent DNA helicase (RecQ)
AWH56_024350	COG0243	molybdopterin cofactor binding
AWH56_024370	COG0243	molybdopterin cofactor binding
AWH56_024375	COG0348	domain, Protein
AWH56_024380	COG0437	4 iron, 4 sulfur cluster binding
AWH56_024395	COG0409	Hydrogenase expression formation protein
AWH56_024400	COG0298	carbon dioxide binding
AWH56_024405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AWH56_024410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AWH56_024430	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AWH56_024440	COG0805	protein transport
AWH56_024445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AWH56_024465	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_024495	COG0326	Molecular chaperone. Has ATPase activity
AWH56_024505	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_024545	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWH56_024560	COG0194	GDP metabolic process
AWH56_024585	COG3428	Bacterial PH domain
AWH56_024590	COG3402	PFAM membrane-flanked domain
AWH56_024600	COG0490	domain, Protein
AWH56_024600	COG0471	metal ion transport
AWH56_024605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AWH56_024610	COG1335	isochorismatase
AWH56_024620	COG1234	tRNA 3'-trailer cleavage
AWH56_024630	COG1528	Iron-storage protein
AWH56_024640	COG0789	Transcriptional regulator
AWH56_024650	COG3331	DNA recombination
AWH56_024655	COG4499	WXG100 protein secretion system (Wss), protein YukC
AWH56_024655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_024665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWH56_024670	COG3935	DnaD domain protein
AWH56_024675	COG0017	Asparaginyl-tRNA synthetase
AWH56_024680	COG0436	Aminotransferase
AWH56_024695	COG0402	S-adenosylhomocysteine deaminase activity
AWH56_024705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWH56_024705	COG1199	ATP-dependent helicase activity
AWH56_024725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AWH56_024735	COG0617	tRNA 3'-terminal CCA addition
AWH56_024740	COG0438	transferase activity, transferring glycosyl groups
AWH56_024745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AWH56_024750	COG1803	Methylglyoxal synthase
AWH56_024755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWH56_024760	COG1694	Mazg nucleotide pyrophosphohydrolase
AWH56_024765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_024770	COG2738	Putative neutral zinc metallopeptidase
AWH56_024780	COG4347	Protein of unknown function (DUF1405)
AWH56_024790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AWH56_024805	COG5582	Belongs to the UPF0302 family
AWH56_024815	COG0457	Tetratricopeptide repeat
AWH56_024825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AWH56_024830	COG0287	Prephenate dehydrogenase
AWH56_024835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWH56_024840	COG0159	tryptophan synthase activity
AWH56_024845	COG0133	tryptophan synthase activity
AWH56_024850	COG0135	phosphoribosylanthranilate isomerase activity
AWH56_024855	COG0134	indole-3-glycerol-phosphate synthase activity
AWH56_024860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWH56_024870	COG4401	Chorismate mutase type I
AWH56_024875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWH56_024880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWH56_024885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AWH56_024890	COG0105	UTP biosynthetic process
AWH56_024895	COG0142	geranyltranstransferase activity
AWH56_024900	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AWH56_024905	COG0163	prenyltransferase activity
AWH56_024910	COG0109	protoheme IX farnesyltransferase activity
AWH56_024915	COG2226	methyltransferase
AWH56_024920	COG0142	geranyltranstransferase activity
AWH56_024930	COG0302	gtp cyclohydrolase
AWH56_024940	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AWH56_024960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWH56_024965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWH56_024970	COG1160	GTP binding
AWH56_024985	COG1304	FMN binding
AWH56_024995	COG0204	Acyl-transferase
AWH56_025000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWH56_025015	COG2959	enzyme of heme biosynthesis
AWH56_025020	COG3409	Peptidoglycan-binding domain 1 protein
AWH56_025020	COG3773	Cell wall hydrolase
AWH56_025025	COG0646	methionine synthase
AWH56_025025	COG1410	methionine synthase
AWH56_025030	COG0646	methionine synthase
AWH56_025030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AWH56_025035	COG0626	cystathionine gamma-synthase activity
AWH56_025040	COG0626	cystathionine gamma-synthase activity
AWH56_025055	COG2339	peptidase activity
AWH56_025065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWH56_025070	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWH56_025075	COG4862	establishment of competence for transformation
AWH56_025080	COG0789	Transcriptional regulator
AWH56_025085	COG1408	metallophosphoesterase
AWH56_025145	COG1266	CAAX protease self-immunity
AWH56_025150	COG0514	ATP-dependent DNA helicase (RecQ)
AWH56_025155	COG4955	Helix-turn-helix domain
AWH56_025160	COG1141	Ferredoxin
AWH56_025170	COG2186	Transcriptional regulator
AWH56_025180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AWH56_025190	COG0739	heme binding
AWH56_025195	COG2720	vancomycin resistance protein
AWH56_025200	COG2096	Adenosyltransferase
AWH56_025210	COG0588	phosphoglycerate mutase activity
AWH56_025215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AWH56_025220	COG1492	cobalamin metabolic process
AWH56_025230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWH56_025235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AWH56_025240	COG1120	ATPase activity
AWH56_025245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_025250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWH56_025255	COG0521	Mo-molybdopterin cofactor biosynthetic process
AWH56_025260	COG5002	protein histidine kinase activity
AWH56_025265	COG0745	RESPONSE REGULATOR receiver
AWH56_025270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWH56_025275	COG1333	cytochrome c biogenesis protein
AWH56_025280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_025285	COG1187	pseudouridine synthase activity
AWH56_025290	COG0700	Nucleoside recognition
AWH56_025295	COG2715	membrane protein required for spore maturation
AWH56_025300	COG1686	Belongs to the peptidase S11 family
AWH56_025305	COG2323	membrane
AWH56_025320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_025350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWH56_025370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWH56_025375	COG1547	Domain of unknown function (DUF309)
AWH56_025380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AWH56_025385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_025385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_025390	COG0307	riboflavin synthase, alpha
AWH56_025395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWH56_025395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWH56_025400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWH56_025405	COG1388	LysM domain
AWH56_025405	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWH56_025410	COG0019	diaminopimelate decarboxylase activity
AWH56_025415	COG0697	spore germination
AWH56_025430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_025455	COG2172	sigma factor antagonist activity
AWH56_025460	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_025465	COG1686	Belongs to the peptidase S11 family
AWH56_025475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AWH56_025495	COG4974	Belongs to the 'phage' integrase family
AWH56_025505	COG0735	belongs to the Fur family
AWH56_025510	COG1300	Membrane
AWH56_025515	COG1379	DNA repair
AWH56_025520	COG0494	nUDIX hydrolase
AWH56_025535	COG0667	Aldo Keto reductase
AWH56_025540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_025545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWH56_025550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWH56_025555	COG1968	undecaprenyl-diphosphatase activity
AWH56_025565	COG0701	Predicted permease
AWH56_025570	COG3689	TIGRFAM TIGR03943 family protein
AWH56_025575	COG0133	tryptophan synthase activity
AWH56_025580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWH56_025585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWH56_025605	COG2414	aldehyde ferredoxin oxidoreductase
AWH56_025610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWH56_025615	COG2226	methyltransferase
AWH56_025645	COG3344	reverse transcriptase
AWH56_025680	COG1227	inorganic diphosphatase activity
AWH56_025685	COG2233	PERMEase
AWH56_025695	COG3829	transcription factor binding
AWH56_025705	COG4720	Psort location CytoplasmicMembrane, score
AWH56_025710	COG0367	asparagine synthase
AWH56_025720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWH56_025735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWH56_025745	COG0300	oxidoreductase activity
AWH56_025760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWH56_025770	COG0527	aspartate kinase activity
AWH56_025775	COG0789	Transcriptional regulator
AWH56_025780	COG2861	carbohydrate metabolic process
AWH56_025790	COG0517	IMP dehydrogenase activity
AWH56_025800	COG1902	pentaerythritol trinitrate reductase activity
AWH56_025815	COG1728	Protein conserved in bacteria
AWH56_025835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWH56_025845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWH56_025860	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWH56_025865	COG0346	lactoylglutathione lyase activity
AWH56_025875	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_025880	COG4129	membrane
AWH56_025885	COG1126	abc transporter atp-binding protein
AWH56_025890	COG0765	amino acid transport
AWH56_025895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWH56_025910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_025915	COG4565	transcriptional regulatory protein
AWH56_025920	COG3290	protein histidine kinase activity
AWH56_025945	COG1484	DNA-dependent DNA replication
AWH56_025960	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWH56_025965	COG0022	dehydrogenase e1 component
AWH56_025970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWH56_025975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWH56_025980	COG3426	butyrate kinase activity
AWH56_025990	COG0280	phosphate acetyltransferase
AWH56_025995	COG3829	transcription factor binding
AWH56_025995	COG3290	protein histidine kinase activity
AWH56_026010	COG0463	Glycosyl transferase, family 2
AWH56_026025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AWH56_026030	COG1882	Formate acetyltransferase
AWH56_026035	COG0745	RESPONSE REGULATOR receiver
AWH56_026040	COG0750	zinc metalloprotease
AWH56_026045	COG0497	DNA recombination
AWH56_026050	COG1438	arginine binding
AWH56_026055	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWH56_026060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AWH56_026085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWH56_026090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWH56_026095	COG1302	Protein conserved in bacteria
AWH56_026100	COG0439	Biotin carboxylase
AWH56_026105	COG0511	ligase activity, forming carbon-carbon bonds
AWH56_026150	COG3854	ATPases associated with a variety of cellular activities
AWH56_026165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWH56_026170	COG0006	proline dipeptidase activity
AWH56_026175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AWH56_026190	COG1321	iron dependent repressor
AWH56_026195	COG1533	DNA photolyase activity
AWH56_026200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWH56_026210	COG0095	Lipoate-protein ligase
AWH56_026215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_026220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWH56_026225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWH56_026230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWH56_026235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWH56_026280	COG4537	Required for transformation and DNA binding
AWH56_026300	COG1459	type II secretion system
AWH56_026305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWH56_026335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_026350	COG0011	TIGRFAM Protein of
AWH56_026360	COG0351	phosphomethylpyrimidine kinase
AWH56_026370	COG0352	thiamine-phosphate diphosphorylase activity