locus-tag	class	description
I6H46_00010	COG1349	DNA-binding transcription factor activity
I6H46_00015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6H46_00030	COG1131	(ABC) transporter
I6H46_00035	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6H46_00040	COG1473	amidohydrolase
I6H46_00045	COG0596	Alpha beta hydrolase
I6H46_00050	COG1278	Cold shock
I6H46_00055	COG2226	methyltransferase
I6H46_00060	COG0525	valine-tRNA ligase activity
I6H46_00065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H46_00070	COG0574	Belongs to the PEP-utilizing enzyme family
I6H46_00070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H46_00090	COG0745	RESPONSE REGULATOR receiver
I6H46_00095	COG2205	protein histidine kinase activity
I6H46_00100	COG1301	dicarboxylic acid transport
I6H46_00115	COG0653	protein targeting
I6H46_00120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H46_00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H46_00135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H46_00145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H46_00150	COG1506	peptidase
I6H46_00150	COG0823	Involved in the tonB-independent uptake of proteins
I6H46_00150	COG4946	Tricorn protease homolog
I6H46_00155	COG1295	ribonuclease BN
I6H46_00160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H46_00170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H46_00175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H46_00190	COG0305	Participates in initiation and elongation during chromosome replication
I6H46_00195	COG0359	binds to the 23S rRNA
I6H46_00200	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6H46_00225	COG1024	Enoyl-CoA hydratase
I6H46_00235	COG1477	protein flavinylation
I6H46_00245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H46_00250	COG0572	uridine kinase
I6H46_00255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H46_00265	COG0590	tRNA wobble adenosine to inosine editing
I6H46_00275	COG1686	Belongs to the peptidase S11 family
I6H46_00295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H46_00300	COG0758	DNA mediated transformation
I6H46_00310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H46_00315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H46_00325	COG0642	Histidine kinase
I6H46_00330	COG1136	(ABC) transporter
I6H46_00340	COG0335	large ribosomal subunit rRNA binding
I6H46_00345	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H46_00350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H46_00360	COG0228	four-way junction DNA binding
I6H46_00365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H46_00370	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6H46_00385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H46_00390	COG1288	antiporter activity
I6H46_00395	COG0549	Belongs to the carbamate kinase family
I6H46_00400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H46_00405	COG2235	arginine
I6H46_00410	COG2207	Transcriptional regulator
I6H46_00410	COG3708	Transcriptional regulator
I6H46_00510	COG0251	oxidation-reduction process
I6H46_00525	COG0018	arginyl-trna synthetase
I6H46_00535	COG0826	peptidase U32
I6H46_00545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_00545	COG0072	phenylalanine-tRNA ligase activity
I6H46_00555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H46_00560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H46_00570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H46_00625	COG5012	cobalamin binding
I6H46_00635	COG0281	malic enzyme
I6H46_00640	COG0114	fumarate hydratase activity
I6H46_00645	COG0583	DNA-binding transcription factor activity
I6H46_00650	COG1794	racemase activity, acting on amino acids and derivatives
I6H46_00655	COG1301	dicarboxylic acid transport
I6H46_00660	COG1027	Aspartate ammonia-lyase
I6H46_00670	COG0584	glycerophosphoryl diester phosphodiesterase
I6H46_00675	COG1924	4 iron, 4 sulfur cluster binding
I6H46_00690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H46_00695	COG0629	single-stranded DNA binding
I6H46_00700	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H46_00705	COG3191	aminopeptidase activity
I6H46_00720	COG0640	Transcriptional regulator
I6H46_00730	COG4824	toxin secretion phage lysis holin
I6H46_00765	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6H46_00790	COG0686	Belongs to the AlaDH PNT family
I6H46_00805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H46_00810	COG3842	ATPase activity
I6H46_00820	COG5426	von Willebrand factor, type A
I6H46_00825	COG0395	ABC-type sugar transport system, permease component
I6H46_00830	COG1175	transmembrane transport
I6H46_00835	COG1653	transport
I6H46_00845	COG1131	(ABC) transporter
I6H46_00850	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H46_00905	COG3340	Belongs to the peptidase S51 family
I6H46_01030	COG0519	Catalyzes the synthesis of GMP from XMP
I6H46_01040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H46_01045	COG0751	glycine-tRNA ligase activity
I6H46_01050	COG0752	glycyl-tRNA synthetase alpha subunit
I6H46_01055	COG1381	Involved in DNA repair and RecF pathway recombination
I6H46_01060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H46_01065	COG0295	cytidine deaminase activity
I6H46_01070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H46_01080	COG1702	phosphate starvation-inducible protein PhoH
I6H46_01090	COG4864	UPF0365 protein
I6H46_01095	COG1030	water channel activity
I6H46_01100	COG1304	FMN binding
I6H46_01105	COG1316	TRANSCRIPTIONal
I6H46_01110	COG0561	phosphatase activity
I6H46_01125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H46_01145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H46_01150	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_01155	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H46_01160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H46_01165	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H46_01175	COG2239	Acts as a magnesium transporter
I6H46_01180	COG0793	Belongs to the peptidase S41A family
I6H46_01205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H46_01210	COG0556	nucleotide-excision repair
I6H46_01215	COG2217	Heavy metal translocating P-type atpase
I6H46_01250	COG0791	NLP P60 protein
I6H46_01270	COG0765	amino acid transport
I6H46_01290	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H46_01305	COG2022	thiamine diphosphate biosynthetic process
I6H46_01310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H46_01325	COG0473	3-isopropylmalate dehydrogenase activity
I6H46_01335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H46_01340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H46_01345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H46_01350	COG1979	alcohol dehydrogenase
I6H46_01450	COG2382	esterase
I6H46_01450	COG3693	PFAM glycoside hydrolase, family 10
I6H46_01485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H46_01505	COG2226	methyltransferase
I6H46_01535	COG0733	neurotransmitter:sodium symporter activity
I6H46_01540	COG0402	S-adenosylhomocysteine deaminase activity
I6H46_01545	COG2252	PERMEase
I6H46_01575	COG1473	amidohydrolase
I6H46_01580	COG1058	Belongs to the CinA family
I6H46_01580	COG1546	Belongs to the CinA family
I6H46_01585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H46_01585	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H46_01590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H46_01590	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H46_01595	COG1083	cytidylyl-transferase
I6H46_01600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H46_01605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H46_01625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H46_01645	COG0402	S-adenosylhomocysteine deaminase activity
I6H46_01650	COG0493	'glutamate synthase
I6H46_01650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H46_01665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H46_01670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H46_01675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H46_01680	COG0709	Synthesizes selenophosphate from selenide and ATP
I6H46_01685	COG0425	Belongs to the sulfur carrier protein TusA family
I6H46_01700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H46_01705	COG4149	molybdate abc transporter
I6H46_01710	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H46_01720	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H46_01725	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H46_01735	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6H46_01750	COG0019	diaminopimelate decarboxylase activity
I6H46_01760	COG1177	transmembrane transport
I6H46_01770	COG3842	ATPase activity
I6H46_01780	COG0789	Transcriptional regulator
I6H46_01805	COG1454	alcohol dehydrogenase
I6H46_01805	COG1012	belongs to the aldehyde dehydrogenase family
I6H46_01815	COG4869	propanediol catabolic process
I6H46_01845	COG1162	GTPase activity
I6H46_01855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H46_01860	COG1882	Formate acetyltransferase
I6H46_01870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H46_01875	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H46_01890	COG2816	NAD+ diphosphatase activity
I6H46_01895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H46_01910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H46_01925	COG1136	(ABC) transporter
I6H46_01940	COG0523	cobalamin synthesis protein
I6H46_01955	COG2081	HI0933 family
I6H46_01960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H46_01965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H46_01970	COG1263	PTS System
I6H46_01970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_01970	COG2190	(PTS) system
I6H46_01985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H46_01990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6H46_02000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_02000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_02005	COG3585	molybdate ion transport
I6H46_02010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H46_02035	COG0644	oxidoreductase
I6H46_02040	COG2226	methyltransferase
I6H46_02060	COG1556	Lactate utilization protein
I6H46_02065	COG0003	Pfam Anion-transporting ATPase
I6H46_02075	COG1346	cytolysis
I6H46_02090	COG2894	cell division
I6H46_02115	COG1045	serine acetyltransferase
I6H46_02140	COG0438	transferase activity, transferring glycosyl groups
I6H46_02170	COG0438	transferase activity, transferring glycosyl groups
I6H46_02175	COG0438	transferase activity, transferring glycosyl groups
I6H46_02200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H46_02210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6H46_02220	COG1316	TRANSCRIPTIONal
I6H46_02225	COG3579	cysteine-type endopeptidase activity
I6H46_02245	COG1214	PFAM Peptidase M22, glycoprotease
I6H46_02250	COG0802	atpase or kinase
I6H46_02280	COG1164	Oligoendopeptidase f
I6H46_02285	COG2309	aminopeptidase activity
I6H46_02385	COG0363	glucosamine-6-phosphate deaminase activity
I6H46_02395	COG3830	Belongs to the UPF0237 family
I6H46_02405	COG0166	Belongs to the GPI family
I6H46_02430	COG0366	Alpha amylase catalytic
I6H46_02435	COG0366	Alpha amylase catalytic
I6H46_02440	COG0366	Alpha amylase catalytic
I6H46_02445	COG0366	Alpha amylase catalytic
I6H46_02475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H46_02480	COG1802	Transcriptional regulator
I6H46_02515	COG2222	sugar isomerase
I6H46_02520	COG3684	Belongs to the aldolase LacD family
I6H46_02525	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H46_02530	COG2971	BadF BadG BcrA BcrD
I6H46_02540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_02545	COG3715	PTS system
I6H46_02550	COG3716	PTS system mannose fructose sorbose family IID component
I6H46_02565	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H46_02565	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H46_02570	COG1121	(ABC) transporter
I6H46_02575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H46_02590	COG1979	alcohol dehydrogenase
I6H46_02600	COG1070	Carbohydrate kinase
I6H46_02605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H46_02620	COG1349	DNA-binding transcription factor activity
I6H46_02625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6H46_02630	COG1285	pathogenesis
I6H46_02635	COG1115	amino acid carrier protein
I6H46_02640	COG0584	glycerophosphoryl diester phosphodiesterase
I6H46_02645	COG1253	flavin adenine dinucleotide binding
I6H46_02650	COG1394	ATPase activity, coupled to movement of substances
I6H46_02655	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6H46_02665	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6H46_02670	COG1527	subunit (C
I6H46_02675	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6H46_02680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H46_02685	COG1269	ATP hydrolysis coupled proton transport
I6H46_02695	COG1494	fructose-1,6-bisphosphatase
I6H46_02705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H46_02730	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6H46_02730	COG3976	FMN-binding domain protein
I6H46_02735	COG3976	FMN-binding domain protein
I6H46_02735	COG1053	succinate dehydrogenase
I6H46_02740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H46_02745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H46_02750	COG1132	(ABC) transporter
I6H46_02760	COG0616	signal peptide processing
I6H46_02765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_02765	COG1263	PTS System
I6H46_02770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H46_02780	COG1737	Transcriptional regulator
I6H46_02785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H46_02790	COG1846	Transcriptional regulator
I6H46_02800	COG3118	belongs to the thioredoxin family
I6H46_02815	COG0280	phosphate acetyltransferase
I6H46_02830	COG1475	DNA binding
I6H46_02835	COG1192	Involved in chromosome partitioning
I6H46_02840	COG1058	Belongs to the CinA family
I6H46_02840	COG1546	Belongs to the CinA family
I6H46_02850	COG0445	tRNA wobble uridine modification
I6H46_02855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H46_02860	COG1847	R3H domain protein
I6H46_02865	COG0706	membrane insertase activity
I6H46_02870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H46_02880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H46_02885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H46_02890	COG0592	DNA-directed DNA polymerase activity
I6H46_02900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H46_02905	COG0187	DNA topoisomerase II activity
I6H46_02910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H46_02925	COG1191	sigma factor activity
I6H46_02930	COG4166	transmembrane transport
I6H46_02935	COG0601	transmembrane transport
I6H46_02940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H46_02945	COG0444	Belongs to the ABC transporter superfamily
I6H46_02950	COG4608	Belongs to the ABC transporter superfamily
I6H46_02950	COG4608	Belongs to the ABC transporter superfamily
I6H46_02970	COG2314	TM2 domain
I6H46_02975	COG1396	sequence-specific DNA binding
I6H46_02975	COG3800	Transcriptional regulator
I6H46_02985	COG0450	alkyl hydroperoxide reductase
I6H46_02990	COG1929	Belongs to the glycerate kinase type-1 family
I6H46_02995	COG0705	Rhomboid family
I6H46_02995	COG0457	Tetratricopeptide repeat
I6H46_03000	COG1164	Oligoendopeptidase f
I6H46_03020	COG0785	Cytochrome C biogenesis protein
I6H46_03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H46_03035	COG2207	Transcriptional regulator
I6H46_03035	COG4753	response regulator
I6H46_03040	COG2972	Histidine kinase
I6H46_03050	COG2252	PERMEase
I6H46_03055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6H46_03060	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H46_03060	COG1024	Enoyl-CoA hydratase
I6H46_03075	COG1757	Na H antiporter
I6H46_03080	COG0583	DNA-binding transcription factor activity
I6H46_03140	COG1640	4-alpha-glucanotransferase
I6H46_03145	COG3842	ATPase activity
I6H46_03150	COG0534	Mate efflux family protein
I6H46_03155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H46_03190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H46_03195	COG0569	domain protein
I6H46_03205	COG4463	regulation of RNA biosynthetic process
I6H46_03220	COG0542	response to heat
I6H46_03245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H46_03250	COG1121	(ABC) transporter
I6H46_03275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H46_03290	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H46_03295	COG1609	Transcriptional regulator
I6H46_03310	COG1129	ABC transporter
I6H46_03315	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H46_03320	COG1879	ABC-type sugar transport system periplasmic component
I6H46_03330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_03335	COG3716	PTS system mannose fructose sorbose family IID component
I6H46_03345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H46_03350	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6H46_03355	COG1737	Transcriptional regulator
I6H46_03360	COG4221	oxidoreductase activity
I6H46_03365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H46_03390	COG0438	transferase activity, transferring glycosyl groups
I6H46_03420	COG1725	Transcriptional regulator
I6H46_03425	COG1131	(ABC) transporter
I6H46_03435	COG1482	cell wall glycoprotein biosynthetic process
I6H46_03455	COG4956	integral membrane protein (PIN domain superfamily)
I6H46_03460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H46_03465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H46_03470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H46_03475	COG1077	Cell shape determining protein MreB Mrl
I6H46_03480	COG0588	phosphoglycerate mutase activity
I6H46_03500	COG0385	Bile acid
I6H46_03505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H46_03510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6H46_03545	COG1518	maintenance of DNA repeat elements
I6H46_03550	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H46_03615	COG0464	growth
I6H46_03620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H46_03625	COG0215	cysteine-tRNA ligase activity
I6H46_03630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H46_03640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H46_03665	COG4152	abc transporter atp-binding protein
I6H46_03700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H46_03705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H46_03715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H46_03720	COG0037	tRNA processing
I6H46_03725	COG1968	undecaprenyl-diphosphatase activity
I6H46_03745	COG1725	Transcriptional regulator
I6H46_03750	COG0842	Transport permease protein
I6H46_03750	COG1129	ABC transporter
I6H46_03760	COG0598	Magnesium transport protein CorA
I6H46_03800	COG1461	Dihydroxyacetone kinase
I6H46_03805	COG3853	Toxic anion resistance protein (TelA)
I6H46_03825	COG3715	PTS system
I6H46_03830	COG3716	PTS system mannose fructose sorbose family IID component
I6H46_03840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H46_03855	COG0668	transmembrane transport
I6H46_03860	COG4481	Protein conserved in bacteria
I6H46_03985	COG0569	domain protein
I6H46_03995	COG1811	Na channel or pump
I6H46_04000	COG0351	phosphomethylpyrimidine kinase
I6H46_04000	COG0352	thiamine-phosphate diphosphorylase activity
I6H46_04015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H46_04020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H46_04030	COG2059	Chromate
I6H46_04035	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H46_04045	COG1528	Iron-storage protein
I6H46_04065	COG0561	phosphatase activity
I6H46_04075	COG4509	Sortase family
I6H46_04085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H46_04110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H46_04115	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H46_04115	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H46_04115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H46_04115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H46_04120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H46_04130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H46_04135	COG2011	ABC-type metal ion transport system permease component
I6H46_04150	COG0456	acetyltransferase
I6H46_04155	COG0210	DNA helicase
I6H46_04165	COG1187	pseudouridine synthase activity
I6H46_04170	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6H46_04195	COG2963	transposase activity
I6H46_04200	COG2801	Transposase and inactivated derivatives
I6H46_04215	COG0601	transmembrane transport
I6H46_04220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H46_04230	COG4608	Belongs to the ABC transporter superfamily
I6H46_04235	COG4166	transmembrane transport
I6H46_04240	COG2801	Transposase and inactivated derivatives
I6H46_04250	COG2963	transposase activity
I6H46_04275	COG1136	(ABC) transporter
I6H46_04290	COG0579	oxidoreductase
I6H46_04295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H46_04300	COG1363	Peptidase, m42
I6H46_04305	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H46_04310	COG3845	ABC transporter
I6H46_04315	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H46_04320	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H46_04350	COG1131	(ABC) transporter
I6H46_04370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H46_04385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H46_04390	COG1442	glycosyl transferase family 8
I6H46_04410	COG1217	gtp-binding protein TYPA
I6H46_04425	COG0488	(ABC) transporter
I6H46_04445	COG1393	Belongs to the ArsC family
I6H46_04465	COG0058	SHG alpha-glucan phosphorylase activity
I6H46_04475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6H46_04495	COG0740	serine-type endopeptidase activity
I6H46_04500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H46_04505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H46_04510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H46_04520	COG1362	aminopeptidase activity
I6H46_04525	COG0011	TIGRFAM Protein of
I6H46_04530	COG2252	PERMEase
I6H46_04535	COG4536	flavin adenine dinucleotide binding
I6H46_04545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6H46_04550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H46_04555	COG1605	Chorismate mutase
I6H46_04555	COG0077	Prephenate dehydratase
I6H46_04565	COG1115	amino acid carrier protein
I6H46_04585	COG1362	aminopeptidase activity
I6H46_04600	COG0534	Mate efflux family protein
I6H46_04605	COG0351	phosphomethylpyrimidine kinase
I6H46_04610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H46_04615	COG2186	Transcriptional regulator
I6H46_04620	COG1131	(ABC) transporter
I6H46_04630	COG2131	deaminase
I6H46_04675	COG1131	(ABC) transporter
I6H46_04680	COG1131	(ABC) transporter
I6H46_04685	COG0051	transcription antitermination factor activity, RNA binding
I6H46_04690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H46_04695	COG0088	Forms part of the polypeptide exit tunnel
I6H46_04700	COG0089	rRNA binding
I6H46_04705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H46_04710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H46_04715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H46_04720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H46_04725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H46_04730	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H46_04735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H46_04740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H46_04745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H46_04750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H46_04755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H46_04760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H46_04765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H46_04770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H46_04775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H46_04780	COG1841	ribosomal large subunit assembly
I6H46_04785	COG0200	Binds to the 23S rRNA
I6H46_04795	COG0563	adenylate kinase activity
I6H46_04800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H46_04805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H46_04810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H46_04815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H46_04820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H46_04825	COG0202	RNA polymerase activity
I6H46_04830	COG0203	ribosomal protein L17
I6H46_04855	COG0205	6-phosphofructokinase activity
I6H46_04885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H46_04895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H46_04900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6H46_04910	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6H46_04925	COG0085	RNA polymerase activity
I6H46_04930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H46_04955	COG3383	formate dehydrogenase (NAD+) activity
I6H46_04960	COG3383	formate dehydrogenase (NAD+) activity
I6H46_04975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H46_04985	COG0303	'Molybdopterin
I6H46_05000	COG1131	(ABC) transporter
I6H46_05010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H46_05015	COG0049	tRNA binding
I6H46_05020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H46_05025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H46_05045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H46_05050	COG1971	Probably functions as a manganese efflux pump
I6H46_05060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H46_05075	COG0138	bifunctional purine biosynthesis protein purh
I6H46_05080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H46_05085	COG0517	IMP dehydrogenase activity
I6H46_05085	COG0516	GMP reductase activity
I6H46_05095	COG1346	cytolysis
I6H46_05100	COG1380	Effector of murein hydrolase LrgA
I6H46_05105	COG0277	FAD linked oxidase domain protein
I6H46_05110	COG1960	acyl-CoA dehydrogenase activity
I6H46_05120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6H46_05125	COG0427	acetyl-CoA hydrolase
I6H46_05130	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H46_05135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H46_05140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H46_05145	COG1876	peptidase activity
I6H46_05150	COG0728	peptidoglycan biosynthetic process
I6H46_05190	COG0410	ABC transporter
I6H46_05215	COG0346	lactoylglutathione lyase activity
I6H46_05240	COG0124	histidyl-tRNA synthetase
I6H46_05275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H46_05315	COG1307	EDD domain protein, DegV family
I6H46_05320	COG2033	superoxide reductase activity
I6H46_05325	COG0116	Belongs to the methyltransferase superfamily
I6H46_05340	COG1122	ATPase activity
I6H46_05345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H46_05350	COG0101	tRNA pseudouridine synthase activity
I6H46_05360	COG0514	ATP-dependent DNA helicase (RecQ)
I6H46_05375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H46_05380	COG0573	inorganic phosphate transmembrane transporter activity
I6H46_05385	COG0581	inorganic phosphate transmembrane transporter activity
I6H46_05390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H46_05395	COG0704	Plays a role in the regulation of phosphate uptake
I6H46_05400	COG0745	RESPONSE REGULATOR receiver
I6H46_05405	COG5002	protein histidine kinase activity
I6H46_05425	COG1960	acyl-CoA dehydrogenase activity
I6H46_05435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H46_05435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H46_05435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H46_05435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H46_05440	COG1408	metallophosphoesterase
I6H46_05475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H46_05480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6H46_05485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H46_05490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H46_05495	COG0151	Belongs to the GarS family
I6H46_05500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H46_05505	COG1301	dicarboxylic acid transport
I6H46_05515	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H46_05515	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H46_05520	COG1121	(ABC) transporter
I6H46_05525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H46_05530	COG3022	response to hydroperoxide
I6H46_05550	COG0419	ATPase involved in DNA repair
I6H46_05560	COG1074	ATP-dependent DNA helicase activity
I6H46_05565	COG1028	Short-chain dehydrogenase reductase Sdr
I6H46_05570	COG0656	L-ascorbic acid biosynthetic process
I6H46_05580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H46_05600	COG0493	'glutamate synthase
I6H46_05610	COG1132	(ABC) transporter
I6H46_05615	COG0484	heat shock protein binding
I6H46_05630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H46_05630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H46_05645	COG1104	cysteine desulfurase activity
I6H46_05650	COG0482	sulfurtransferase activity
I6H46_05660	COG0606	chelatase, subunit chli
I6H46_05665	COG0564	pseudouridine synthase activity
I6H46_05675	COG4589	Belongs to the CDS family
I6H46_05680	COG0750	zinc metalloprotease
I6H46_05685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H46_05695	COG0697	spore germination
I6H46_05700	COG0779	Required for maturation of 30S ribosomal subunits
I6H46_05705	COG0195	Participates in both transcription termination and antitermination
I6H46_05710	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H46_05720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H46_05725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H46_05730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H46_05735	COG0196	riboflavin kinase activity
I6H46_05745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H46_05750	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H46_05760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H46_05765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H46_05770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H46_05775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H46_05785	COG0037	tRNA processing
I6H46_05790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H46_05800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6H46_05805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H46_05810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H46_05815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H46_05830	COG1484	DNA-dependent DNA replication
I6H46_05865	COG1132	(ABC) transporter
I6H46_05870	COG1132	(ABC) transporter
I6H46_05875	COG1129	ABC transporter
I6H46_05990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H46_05990	COG0551	DNA topoisomerase type I activity
I6H46_06020	COG0745	RESPONSE REGULATOR receiver
I6H46_06025	COG2205	protein histidine kinase activity
I6H46_06065	COG0577	efflux transmembrane transporter activity
I6H46_06065	COG1136	(ABC) transporter
I6H46_06200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H46_06215	COG4555	ABC transporter
I6H46_06260	COG2091	lysine biosynthetic process via aminoadipic acid
I6H46_06265	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6H46_06305	COG3433	isochorismatase activity
I6H46_06305	COG2226	methyltransferase
I6H46_06305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H46_06385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H46_06385	COG3433	isochorismatase activity
I6H46_06385	COG2226	methyltransferase
I6H46_06480	COG0534	Mate efflux family protein
I6H46_06515	COG1136	(ABC) transporter
I6H46_06520	COG1136	(ABC) transporter
I6H46_06550	COG1136	(ABC) transporter
I6H46_06560	COG3843	relaxase mobilization nuclease domain protein
I6H46_06595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_06595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_06615	COG1131	(ABC) transporter
I6H46_06630	COG0745	RESPONSE REGULATOR receiver
I6H46_06635	COG5002	protein histidine kinase activity
I6H46_06690	COG2094	Belongs to the DNA glycosylase MPG family
I6H46_06695	COG1597	lipid kinase activity
I6H46_06705	COG0733	neurotransmitter:sodium symporter activity
I6H46_06710	COG0733	neurotransmitter:sodium symporter activity
I6H46_06715	COG2843	Capsule synthesis protein
I6H46_06720	COG0671	phosphoesterase, PA-phosphatase related
I6H46_06735	COG0237	dephospho-CoA kinase activity
I6H46_06740	COG0741	lytic transglycosylase activity
I6H46_06745	COG4656	Part of a membrane complex involved in electron transport
I6H46_06750	COG4658	electron transport chain
I6H46_06760	COG4660	Part of a membrane complex involved in electron transport
I6H46_06765	COG4657	Part of a membrane complex involved in electron transport
I6H46_06770	COG2878	Part of a membrane complex involved in electron transport
I6H46_06770	COG1245	4Fe-4S binding domain
I6H46_06785	COG2003	Belongs to the UPF0758 family
I6H46_06795	COG1792	Involved in formation and maintenance of cell shape
I6H46_06805	COG0768	penicillin binding
I6H46_06815	COG1530	ribonuclease E activity
I6H46_06825	COG2137	regulation of response to DNA damage stimulus
I6H46_06860	COG0233	cytoplasmic translational termination
I6H46_06865	COG1459	type II secretion system
I6H46_06900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H46_06905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H46_06910	COG0416	fatty acid biosynthetic process
I6H46_06915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H46_06920	COG0571	ribonuclease III activity
I6H46_06935	COG0242	peptide deformylase activity
I6H46_06940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H46_06945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H46_06945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H46_06950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H46_06960	COG0515	serine threonine protein kinase
I6H46_06960	COG2815	serine threonine protein kinase
I6H46_06970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H46_06975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H46_06980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H46_06985	COG1660	Displays ATPase and GTPase activities
I6H46_06995	COG1481	regulation of sporulation
I6H46_07000	COG0587	DNA-directed DNA polymerase activity
I6H46_07005	COG0205	6-phosphofructokinase activity
I6H46_07015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H46_07095	COG0745	RESPONSE REGULATOR receiver
I6H46_07105	COG0577	efflux transmembrane transporter activity
I6H46_07105	COG1136	(ABC) transporter
I6H46_07115	COG0433	COG0433 Predicted ATPase
I6H46_07130	COG1132	(ABC) transporter
I6H46_07135	COG1132	(ABC) transporter
I6H46_07150	COG1129	ABC transporter
I6H46_07210	COG0484	heat shock protein binding
I6H46_07225	COG0602	queuosine metabolic process
I6H46_07260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H46_07295	COG1309	transcriptional regulator
I6H46_07310	COG0444	Belongs to the ABC transporter superfamily
I6H46_07315	COG4608	Belongs to the ABC transporter superfamily
I6H46_07320	COG0747	negative chemotaxis
I6H46_07325	COG1132	(ABC) transporter
I6H46_07325	COG2375	cellular response to nickel ion
I6H46_07330	COG1132	(ABC) transporter
I6H46_07365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_07365	COG2190	(PTS) system
I6H46_07365	COG1263	PTS System
I6H46_07375	COG2188	Transcriptional regulator
I6H46_07390	COG1395	domain, Protein
I6H46_07410	COG1401	restriction endodeoxyribonuclease activity
I6H46_07555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H46_07555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H46_07560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H46_07575	COG0716	FMN binding
I6H46_07580	COG2376	Dihydroxyacetone kinase
I6H46_07595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H46_07600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H46_07605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H46_07615	COG0398	Pfam SNARE associated Golgi protein
I6H46_07640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H46_07650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H46_07655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H46_07665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H46_07670	COG0081	regulation of translation
I6H46_07675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H46_07680	COG0222	ribosome binding
I6H46_07695	COG0285	dihydrofolate synthase activity
I6H46_07700	COG1288	antiporter activity
I6H46_07705	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_07710	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_07715	COG2801	Transposase and inactivated derivatives
I6H46_07725	COG2963	transposase activity
I6H46_07735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H46_07740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H46_07745	COG0297	glycogen (starch) synthase activity
I6H46_07750	COG0058	SHG alpha-glucan phosphorylase activity
I6H46_07755	COG1523	belongs to the glycosyl hydrolase 13 family
I6H46_07760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H46_07770	COG0772	Belongs to the SEDS family
I6H46_07775	COG0768	penicillin binding
I6H46_07780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H46_07785	COG0564	pseudouridine synthase activity
I6H46_07805	COG1609	Transcriptional regulator
I6H46_07815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H46_07825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H46_07835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H46_07865	COG0564	pseudouridine synthase activity
I6H46_07870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H46_07880	COG0745	RESPONSE REGULATOR receiver
I6H46_07885	COG5002	protein histidine kinase activity
I6H46_07895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H46_07920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H46_07925	COG0632	four-way junction helicase activity
I6H46_07930	COG2255	four-way junction helicase activity
I6H46_07940	COG0343	queuine tRNA-ribosyltransferase activity
I6H46_07950	COG1115	amino acid carrier protein
I6H46_07955	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H46_07955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H46_07960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H46_07975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H46_07985	COG1160	GTP binding
I6H46_07990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H46_08000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H46_08005	COG1799	cell septum assembly
I6H46_08030	COG1104	cysteine desulfurase activity
I6H46_08035	COG0301	tRNA thio-modification
I6H46_08040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H46_08045	COG2868	ribosomal protein
I6H46_08050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H46_08055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H46_08060	COG1534	Rna-binding protein
I6H46_08065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H46_08070	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H46_08075	COG0799	negative regulation of ribosome biogenesis
I6H46_08080	COG1555	photosystem II stabilization
I6H46_08080	COG1596	polysaccharide export
I6H46_08085	COG1959	2 iron, 2 sulfur cluster binding
I6H46_08090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H46_08095	COG4472	Bacterial protein of unknown function (DUF965)
I6H46_08100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H46_08115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6H46_08120	COG4122	O-methyltransferase activity
I6H46_08125	COG0826	peptidase U32
I6H46_08140	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_08145	COG0756	dUTP diphosphatase activity
I6H46_08155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H46_08160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H46_08165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H46_08170	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6H46_08175	COG4974	Belongs to the 'phage' integrase family
I6H46_08180	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H46_08180	COG1388	LysM domain
I6H46_08195	COG1418	mRNA catabolic process
I6H46_08200	COG1132	(ABC) transporter
I6H46_08205	COG1132	(ABC) transporter
I6H46_08210	COG1045	serine acetyltransferase
I6H46_08215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H46_08220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H46_08225	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H46_08230	COG0552	protein localization to endoplasmic reticulum
I6H46_08235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H46_08240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H46_08245	COG1758	RNA polymerase activity
I6H46_08250	COG0194	GDP metabolic process
I6H46_08260	COG0776	regulation of translation
I6H46_08270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H46_08275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H46_08280	COG0193	aminoacyl-tRNA hydrolase activity
I6H46_08290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H46_08300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H46_08305	COG0698	ribose 5-phosphate isomerase
I6H46_08320	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6H46_08325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H46_08330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H46_08330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H46_08335	COG0402	S-adenosylhomocysteine deaminase activity
I6H46_08340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H46_08350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H46_08355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H46_08360	COG0210	DNA helicase
I6H46_08365	COG4496	protein, YerC YecD
I6H46_08370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6H46_08375	COG3442	glutamine amidotransferase
I6H46_08380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H46_08390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H46_08395	COG0167	dihydroorotate dehydrogenase activity
I6H46_08400	COG0543	2 iron, 2 sulfur cluster binding
I6H46_08405	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H46_08420	COG0540	Belongs to the ATCase OTCase family
I6H46_08445	COG0588	phosphoglycerate mutase activity
I6H46_08455	COG1136	(ABC) transporter
I6H46_08460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H46_08465	COG0557	exoribonuclease II activity
I6H46_08475	COG0148	phosphopyruvate hydratase activity
I6H46_08480	COG0149	triose-phosphate isomerase activity
I6H46_08485	COG0126	phosphoglycerate kinase activity
I6H46_08500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H46_08505	COG0561	phosphatase activity
I6H46_08510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H46_08515	COG0772	Belongs to the SEDS family
I6H46_08520	COG4475	Protein of unknown function (DUF436)
I6H46_08555	COG1269	ATP hydrolysis coupled proton transport
I6H46_08570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H46_08575	COG0539	negative regulation of cytoplasmic translation
I6H46_08575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H46_08580	COG0204	Acyl-transferase
I6H46_08585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H46_08590	COG2081	HI0933 family
I6H46_08595	COG1187	pseudouridine synthase activity
I6H46_08600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H46_08610	COG1051	belongs to the nudix hydrolase family
I6H46_08615	COG0497	DNA recombination
I6H46_08620	COG1438	arginine binding
I6H46_08640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H46_08650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H46_08655	COG1323	Belongs to the UPF0348 family
I6H46_08670	COG0742	ribosomal rna small subunit methyltransferase
I6H46_08690	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H46_08690	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H46_08690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H46_08690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H46_08700	COG0322	excinuclease ABC activity
I6H46_08705	COG0006	proline dipeptidase activity
I6H46_08710	COG0012	GTP binding
I6H46_08720	COG0183	Belongs to the thiolase family
I6H46_08725	COG1114	Component of the transport system for branched-chain amino acids
I6H46_08730	COG0024	Methionine aminopeptidase
I6H46_08735	COG0778	Nitroreductase
I6H46_08740	COG0210	DNA helicase
I6H46_08745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H46_08755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H46_08760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H46_08765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H46_08785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H46_08790	COG2207	Transcriptional regulator
I6H46_08790	COG1917	Cupin 2, conserved barrel domain protein
I6H46_08805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H46_08825	COG1774	PSP1 C-terminal conserved region
I6H46_08835	COG3870	Protein conserved in bacteria
I6H46_08840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H46_08845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H46_08850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H46_08860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H46_08875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H46_08880	COG2384	SAM-dependent methyltransferase
I6H46_08885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H46_08885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H46_08890	COG0358	DNA primase activity
I6H46_08895	COG1012	belongs to the aldehyde dehydrogenase family
I6H46_08900	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H46_08905	COG1950	PFAM Membrane protein of
I6H46_08910	COG1254	Belongs to the acylphosphatase family
I6H46_08915	COG2217	Heavy metal translocating P-type atpase
I6H46_08950	COG0039	L-malate dehydrogenase activity
I6H46_08955	COG0494	nUDIX hydrolase
I6H46_08975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H46_08990	COG5522	Integral membrane protein (intg_mem_TP0381)
I6H46_09015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H46_09020	COG0537	adenosine 5'-monophosphoramidase activity
I6H46_09025	COG1114	Component of the transport system for branched-chain amino acids
I6H46_09040	COG1597	lipid kinase activity
I6H46_09045	COG0708	Exodeoxyribonuclease III
I6H46_09050	COG2321	neutral zinc metallopeptidase
I6H46_09055	COG0640	Transcriptional regulator
I6H46_09065	COG2217	Heavy metal translocating P-type atpase
I6H46_09075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6H46_09090	COG1115	amino acid carrier protein
I6H46_09095	COG1757	Na H antiporter
I6H46_09100	COG1115	amino acid carrier protein
I6H46_09110	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6H46_09130	COG1757	Na H antiporter
I6H46_09140	COG1132	(ABC) transporter
I6H46_09175	COG1316	TRANSCRIPTIONal
I6H46_09190	COG1982	Orn Lys Arg decarboxylase major
I6H46_09210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H46_09215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H46_09220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H46_09225	COG0009	L-threonylcarbamoyladenylate synthase
I6H46_09230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H46_09235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H46_09240	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H46_09245	COG0254	rRNA binding
I6H46_09255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H46_09270	COG0442	prolyl-tRNA aminoacylation
I6H46_09275	COG2190	(PTS) system
I6H46_09280	COG2183	response to ionizing radiation
I6H46_09300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H46_09305	COG0484	heat shock protein binding
I6H46_09310	COG0443	Heat shock 70 kDa protein
I6H46_09315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H46_09320	COG1420	regulation of RNA biosynthetic process
I6H46_09325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H46_09330	COG0481	GTPase activity
I6H46_09335	COG0681	Belongs to the peptidase S26 family
I6H46_09340	COG0268	Binds directly to 16S ribosomal RNA
I6H46_09350	COG0658	competence protein
I6H46_09350	COG2333	competence protein COMEC
I6H46_09360	COG0495	leucyl-tRNA aminoacylation
I6H46_09370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H46_09375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H46_09380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H46_09390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H46_09395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H46_09400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H46_09410	COG0275	rRNA processing
I6H46_09415	COG2001	Belongs to the MraZ family
I6H46_09420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H46_09425	COG0217	transcriptional regulatory protein
I6H46_09430	COG1739	Uncharacterized protein family UPF0029
I6H46_09435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H46_09445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H46_09460	COG0745	RESPONSE REGULATOR receiver
I6H46_09465	COG5002	protein histidine kinase activity
I6H46_09485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H46_09490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H46_09505	COG0235	Class ii aldolase
I6H46_09515	COG3037	sugar-specific permease SgaT UlaA
I6H46_09520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system