locus-tag	class	description
Apre_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Apre_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Apre_0004	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Apre_0005	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Apre_0006	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Apre_0007	ENOG4105WN5	stage II sporulation protein
Apre_0014	ENOG4108J59	Extracellular solute-binding protein, family 5
Apre_0015	ENOG4108J59	Extracellular solute-binding protein, family 5
Apre_0017	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Apre_0018	ENOG4105C3U	ABC transporter
Apre_0019	ENOG4108JQ7	(ABC) transporter
Apre_0021	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Apre_0030	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Apre_0031	ENOG4105DBV	ornithine carbamoyltransferase
Apre_0035	ENOG4105E98	transcriptional regulator DeoR family
Apre_0037	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
Apre_0038	ENOG4105D9N	nucleoside
Apre_0041	ENOG4105DBV	ornithine carbamoyltransferase
Apre_0043	ENOG4105C7J	ABC transporter, permease
Apre_0047	ENOG4108JU3	Alkyl hydroperoxide reductase
Apre_0048	ENOG4105D3R	alkyl hydroperoxide reductase
Apre_0052	ENOG4105F38	ABC transporter, permease
Apre_0053	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Apre_0055	ENOG4105BZW	Glycerate kinase
Apre_0056	ENOG4107ZXI	Rhomboid family
Apre_0058	ENOG4105DPN	Oligoendopeptidase f
Apre_0060	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
Apre_0063	ENOG4105DRS	transport system, permease
Apre_0073	ENOG4105E98	transcriptional regulator DeoR family
Apre_0075	ENOG4105E70	isomerase
Apre_0076	ENOG4105FDP	GntR family transcriptional regulator
Apre_0077	ENOG4105CE4	GlcNAc 6-P deacetylase
Apre_0078	ENOG4106VEM	tagatose-6-phosphate kinase
Apre_0079	ENOG4105D2M	Aldolase
Apre_0081	ENOG4105C1G	acyl-Coa dehydrogenase
Apre_0082	ENOG4105CNW	domain protein
Apre_0086	ENOG4105F44	Two component transcriptional regulator, winged helix family
Apre_0087	ENOG4105US7	Histidine kinase
Apre_0092	ENOG4108IJ0	Aspartate ammonia-lyase
Apre_0093	ENOG4105C9Q	fumarate hydratase class II
Apre_0101	ENOG4107VXZ	Hydrolase
Apre_0106	ENOG4105D7N	magnesium and cobalt transport protein CorA
Apre_0109	ENOG4105DER	m42 family
Apre_0114	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
Apre_0115	ENOG4108Z7G	MaoC domain protein dehydratase
Apre_0116	ENOG4105C09	Bile acid
Apre_0117	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Apre_0118	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Apre_0122	ENOG4107ZYR	domain protein
Apre_0124	ENOG4105KEX	transcriptional regulator, ctsr
Apre_0125	ENOG4108Z0C	Uvrb UvrC protein
Apre_0126	ENOG41066A3	ATP guanido phosphotransferase
Apre_0127	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Apre_0131	ENOG4105D56	permease protein
Apre_0132	ENOG4105EG2	ABC transporter, permease
Apre_0134	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Apre_0136	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Apre_0140	ENOG4105CTZ	aminopeptidase c
Apre_0141	ENOG4105DG6	mannose-6-phosphate isomerase
Apre_0145	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Apre_0148	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
Apre_0149	ENOG4105C8I	hydrolase, family 38
Apre_0151	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
Apre_0153	ENOG4105CS2	ec 3.2.1.21
Apre_0154	ENOG4105EVU	fructokinase
Apre_0155	ENOG4105DAP	Nicotinate phosphoribosyltransferase
Apre_0156	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Apre_0159	ENOG4105BZF	Glycosyl transferase (Group 1
Apre_0160	ENOG4105W2C	Glycosyl transferase
Apre_0166	ENOG4105N67	Proton-coupled thiamine transporter YuaJ
Apre_0168	ENOG4105DA5	(ABC) transporter
Apre_0170	ENOG4105DA5	(ABC) transporter
Apre_0172	ENOG4105CBD	Diacylglycerol kinase
Apre_0174	ENOG4105CTP	PilT protein domain protein
Apre_0175	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Apre_0177	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Apre_0178	ENOG4105DFF	Rod shape-determining protein mreb
Apre_0182	ENOG4105K8N	protein family UPF0079, ATPase
Apre_0183	ENOG41072GX	Peptidase M22 Glycoprotease
Apre_0184	ENOG410645S	MarR family Transcriptional regulator
Apre_0185	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Apre_0189	ENOG4108KGH	TRANSCRIPTIONal
Apre_0190	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Apre_0191	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
Apre_0192	ENOG4105CJ1	ABC, transporter
Apre_0194	ENOG4105DP4	dak2 domain fusion protein ylov
Apre_0199	ENOG4105EE0	oxidoreductase
Apre_0201	ENOG4105ETZ	PTS System
Apre_0202	ENOG4105F3R	pts system mannose fructose sorbose family iid
Apre_0204	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Apre_0205	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Apre_0207	ENOG4105D8X	mechanosensitive ion channel
Apre_0208	ENOG4105VDK	protein, conserved in bacteria
Apre_0209	ENOG4105VXR	cytoplasmic protein
Apre_0215	ENOG4105BZ1	(ABC) transporter
Apre_0216	ENOG410667J	hydrolase
Apre_0217	ENOG4105J7I	hydrolase
Apre_0218	ENOG4105C5Y	PTS System
Apre_0219	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Apre_0220	ENOG4105CH2	amidohydrolase
Apre_0224	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Apre_0225	ENOG4105CSW	GntR family transcriptional regulator
Apre_0227	ENOG4108IUX	(ABC) transporter
Apre_0228	ENOG4105RHA	ABC transporter, permease
Apre_0229	ENOG4105C6K	Malic enzyme
Apre_0232	ENOG4105Q2H	domain protein
Apre_0233	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Apre_0234	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Apre_0235	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Apre_0236	ENOG4108R6W	Transcriptional regulator, ARAC family
Apre_0237	ENOG4105DME	alpha-galactosidase
Apre_0238	ENOG4107YY3	extracellular solute-binding protein family 1
Apre_0241	ENOG4107RK0	Sucrose phosphorylase
Apre_0242	ENOG4108IJ9	(ABC) transporter
Apre_0243	ENOG4105CG3	alpha amylase, catalytic region
Apre_0244	ENOG4105D6U	Sodium Glutamate Symporter
Apre_0245	ENOG4107R51	Glycosyl transferase, family 2
Apre_0252	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Apre_0253	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
Apre_0254	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
Apre_0255	ENOG4108IJG	ABC transporter substrate-binding protein
Apre_0258	ENOG4105CEU	Arginine dihydrolase
Apre_0266	ENOG4105CN1	protease
Apre_0267	ENOG4105CJW	magnesium transporter
Apre_0271	ENOG4107QW8	radical SAM domain protein
Apre_0272	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Apre_0274	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Apre_0275	ENOG4108UMI	ABC transporter, permease
Apre_0276	ENOG4105D01	(LipO)protein
Apre_0277	ENOG4105D01	(LipO)protein
Apre_0278	ENOG4105CK2	sodium dicarboxylate symporter
Apre_0280	ENOG4105CVG	Homoserine O-transsuccinylase
Apre_0282	ENOG4108V06	Glutathione peroxidase
Apre_0284	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Apre_0285	ENOG4108Z4K	mutator MutT protein
Apre_0287	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Apre_0289	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Apre_0291	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Apre_0293	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
Apre_0294	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Apre_0295	ENOG4105DIH	basic membrane
Apre_0296	ENOG4108JQ9	ABC transporter
Apre_0297	ENOG4105UIB	(ABC) transporter
Apre_0302	ENOG4105EXC	Acyl-transferase
Apre_0305	ENOG4105CSV	Glutaminase
Apre_0315	ENOG4105D4P	Coproporphyrinogen iii oxidase
Apre_0316	ENOG4105CIN	aminoacyl-histidine dipeptidase
Apre_0317	ENOG4105CIZ	coA-substrate-specific enzyme activase
Apre_0319	ENOG4105KMT	branched-chain amino acid
Apre_0320	ENOG4108UMN	azlc family
Apre_0327	ENOG4105DI5	UPF0365 protein
Apre_0329	ENOG4105C9A	Phoh family
Apre_0330	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Apre_0331	ENOG4105KG3	cytidine deaminase
Apre_0332	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Apre_0333	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
Apre_0334	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
Apre_0335	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Apre_0336	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Apre_0337	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Apre_0344	ENOG4105HMI	Membrane
Apre_0345	ENOG4105DUM	transcriptional regulator, lysR family
Apre_0346	ENOG4107QMH	DNA methylase
Apre_0347	ENOG4107J0C	type IIi
Apre_0349	ENOG4105D7A	ATP-binding protein
Apre_0351	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Apre_0355	ENOG4108UXE	Protein tyrosine phosphatase
Apre_0356	ENOG4105D6J	arsenicaL-resistance protein
Apre_0361	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
Apre_0362	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
Apre_0365	ENOG4105C9B	Cysteine desulfurase
Apre_0368	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
Apre_0370	ENOG4105C8B	TIGR00159 family
Apre_0373	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Apre_0374	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Apre_0375	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Apre_0376	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Apre_0377	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Apre_0378	ENOG4107EFR	Flavocytochrome c
Apre_0379	ENOG4106N3A	copper homeostasis protein cutc
Apre_0380	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
Apre_0381	ENOG4105E98	transcriptional regulator DeoR family
Apre_0382	ENOG4105DE4	1-phosphofructokinase
Apre_0383	ENOG4105DM4	PTS System
Apre_0385	ENOG4105DFM	M18 family aminopeptidase
Apre_0389	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Apre_0390	ENOG4105C3U	ABC transporter
Apre_0391	ENOG4108JQ7	(ABC) transporter
Apre_0392	ENOG4105NBU	tryptophan transport protein
Apre_0393	ENOG4105C7N	Xanthine uracil vitamin C permease
Apre_0394	ENOG4108JU6	CBS domain protein
Apre_0396	ENOG4108XXK	NUDIX hydrolase
Apre_0397	ENOG4105CK2	sodium dicarboxylate symporter
Apre_0402	ENOG4105DFM	M18 family aminopeptidase
Apre_0404	ENOG4105DB7	PHP domain protein
Apre_0407	ENOG4105DA5	(ABC) transporter
Apre_0411	ENOG4106F5Q	Membrane
Apre_0413	ENOG4108IUJ	4-alpha-glucanotransferase
Apre_0417	ENOG4105BZ1	(ABC) transporter
Apre_0427	ENOG4105UQX	Mate efflux family protein
Apre_0429	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Apre_0430	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
Apre_0431	ENOG4105DVE	abc transporter atp-binding protein
Apre_0433	ENOG4108UK2	deaminase
Apre_0434	ENOG410667J	hydrolase
Apre_0435	ENOG4105DE4	1-phosphofructokinase
Apre_0436	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
Apre_0437	ENOG4105CPF	Cell wall formation (By similarity)
Apre_0440	ENOG4105CAG	UPF0210 protein
Apre_0441	ENOG4107ZE5	PPIases accelerate the folding of proteins
Apre_0443	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
Apre_0446	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Apre_0447	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Apre_0449	ENOG4105CMQ	Chloride channel
Apre_0450	ENOG4105KWG	Pfam:DUF1696
Apre_0452	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Apre_0453	ENOG4105CI1	PTS System
Apre_0454	ENOG4105F8D	glycoside hydrolase family 4
Apre_0456	ENOG4106G6Q	Transcriptional regulator
Apre_0457	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Apre_0458	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Apre_0459	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Apre_0460	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Apre_0461	ENOG4105DSE	periplasmic solute binding protein
Apre_0462	ENOG4105DIK	(ABC) transporter
Apre_0465	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Apre_0466	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Apre_0467	ENOG4105C3U	ABC transporter
Apre_0468	ENOG4108JQ7	(ABC) transporter
Apre_0469	ENOG4108J59	Extracellular solute-binding protein, family 5
Apre_0473	ENOG4105C5Y	PTS System
Apre_0474	ENOG4105CG3	alpha amylase, catalytic region
Apre_0478	ENOG4105C19	ABC transporter
Apre_0479	ENOG4105CG3	alpha amylase, catalytic region
Apre_0483	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Apre_0484	ENOG4108UUM	single-stranded DNA-binding protein
Apre_0486	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Apre_0487	ENOG4105CDH	Citrulline--aspartate ligase
Apre_0488	ENOG4105CH7	arginosuccinase
Apre_0489	ENOG4108HW3	(ABC) transporter
Apre_0491	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Apre_0492	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Apre_0493	ENOG4105C9X	ppx gppa phosphatase
Apre_0494	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Apre_0495	ENOG4108VXD	carboxy-peptidase
Apre_0496	ENOG4105KME	endoribonuclease L-psp
Apre_0497	ENOG4105CH2	amidohydrolase
Apre_0498	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Apre_0500	ENOG4105DSE	periplasmic solute binding protein
Apre_0501	ENOG4105FDK	ABC transporter
Apre_0502	ENOG4105FAV	ABC, transporter
Apre_0503	ENOG4105C26	Dehydrogenase
Apre_0504	ENOG4105CNW	domain protein
Apre_0505	ENOG4105C1G	acyl-Coa dehydrogenase
Apre_0507	ENOG4107QMG	Nad synthetase
Apre_0510	ENOG4105CK2	sodium dicarboxylate symporter
Apre_0516	ENOG4105DSE	periplasmic solute binding protein
Apre_0517	ENOG4105FDK	ABC transporter
Apre_0519	ENOG4105D1Q	UPF0246 protein
Apre_0522	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Apre_0523	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Apre_0529	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
Apre_0530	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
Apre_0534	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Apre_0535	ENOG4105CDU	Replicative dna helicase
Apre_0539	ENOG4107U9W	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
Apre_0541	ENOG4107YJ4	chain length determinant protein
Apre_0542	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
Apre_0544	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
Apre_0545	ENOG4105CV8	reductase
Apre_0546	ENOG4105CH6	catalase
Apre_0547	ENOG4105YA8	Transcriptional regulator
Apre_0548	ENOG4105EYF	MMPL domain protein
Apre_0550	ENOG4105BZ8	glutamate synthase
Apre_0551	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
Apre_0552	ENOG4105BZ1	(ABC) transporter
Apre_0553	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Apre_0556	ENOG4105E0X	reductase
Apre_0565	ENOG4105C3J	Cysteine desulfurase
Apre_0566	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Apre_0576	ENOG4105DG4	malate L-lactate dehydrogenase
Apre_0578	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Apre_0581	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Apre_0582	ENOG4105CGK	Exodeoxyribonuclease III
Apre_0583	ENOG4105C34	Pseudouridine synthase
Apre_0584	ENOG4105C0P	Mg chelatase subunit ChlI
Apre_0585	ENOG4107QHF	type ii secretion system protein e
Apre_0591	ENOG41067QW	Transcriptional regulator
Apre_0595	ENOG4105KNE	Phosphatidate cytidylyltransferase
Apre_0596	ENOG4105DZP	Membrane-associated zinc metalloprotease
Apre_0597	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Apre_0598	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
Apre_0606	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Apre_0607	ENOG4105CHV	Transcription elongation factor NusA
Apre_0609	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Apre_0610	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Apre_0611	ENOG4105SFS	phosphoesterase RecJ domain protein
Apre_0612	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Apre_0613	ENOG4105DTN	riboflavin biosynthesis protein ribF
Apre_0614	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Apre_0615	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Apre_0616	ENOG4105CNU	cell division protein FtsK
Apre_0617	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Apre_0618	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Apre_0619	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Apre_0620	ENOG41082I2	s4 domain protein
Apre_0622	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Apre_0623	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Apre_0625	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Apre_0626	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Apre_0627	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Apre_0628	ENOG4105CRK	lysyL-tRNA synthetase
Apre_0633	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
Apre_0636	ENOG4105CM4	permease protein
Apre_0637	ENOG4108IPW	abc transporter atp-binding protein
Apre_0639	ENOG410841Q	phosphoesterase PA-phosphatase related protein
Apre_0643	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Apre_0644	ENOG4105C08	Histidine kinase
Apre_0645	ENOG4107QJQ	Mate efflux family protein
Apre_0646	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Apre_0647	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Apre_0648	ENOG4105D7Q	type ii secretion system
Apre_0650	ENOG4106A3R	peptidase
Apre_0655	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Apre_0656	ENOG41067VY	50S ribosomal protein L32
Apre_0657	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Apre_0658	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Apre_0659	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Apre_0662	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Apre_0663	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Apre_0664	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Apre_0665	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Apre_0667	ENOG4105D9P	serine threonine protein kinase
Apre_0668	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Apre_0669	ENOG4105DJV	ribulose-phosphate 3-epimerase
Apre_0670	ENOG4105VB9	50S ribosomal protein l28
Apre_0671	ENOG4105D4A	Cell wall formation (By similarity)
Apre_0674	ENOG4105CIE	May be required for sporulation (By similarity)
Apre_0675	ENOG4105C0B	DNA polymerase III (alpha subunit)
Apre_0676	ENOG4105CTQ	phosphohexokinase
Apre_0677	ENOG4105CA9	Pyruvate kinase
Apre_0678	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Apre_0684	ENOG4105YA8	Transcriptional regulator
Apre_0687	ENOG4105C3U	ABC transporter
Apre_0688	ENOG4108JQ7	(ABC) transporter
Apre_0689	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
Apre_0690	ENOG4105BZ1	(ABC) transporter
Apre_0691	ENOG4105BZ1	(ABC) transporter
Apre_0701	ENOG4107SIG	periplasmic solute binding protein
Apre_0702	ENOG4105DIK	(ABC) transporter
Apre_0703	ENOG4105CC5	ABC transporter
Apre_0704	ENOG4107RBD	ABC, transporter
Apre_0707	ENOG4105BZ1	(ABC) transporter
Apre_0708	ENOG4105BZ1	(ABC) transporter
Apre_0722	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
Apre_0723	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
Apre_0724	ENOG4108XNJ	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
Apre_0725	ENOG4108YZ9	Urea amidohydrolase subunit gamma
Apre_0726	ENOG4108YZ9	Urea amidohydrolase subunit gamma
Apre_0727	ENOG4105CQM	Urea amidohydrolase subunit alpha
Apre_0742	ENOG4105BZU	Histidine kinase
Apre_0743	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Apre_0748	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Apre_0749	ENOG4105D2N	Aldolase
Apre_0750	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Apre_0751	ENOG41082DI	50s ribosomal protein l31
Apre_0752	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Apre_0753	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Apre_0755	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Apre_0756	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Apre_0757	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Apre_0758	ENOG4105C7H	Helicase, RecD TraA family
Apre_0759	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Apre_0760	ENOG4105CNI	cell division protein FtsW
Apre_0761	ENOG4105CSM	endonuclease III
Apre_0763	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Apre_0766	ENOG4105BZA	Phosphoglycerate kinase
Apre_0767	ENOG4105CP7	Triose-phosphate isomerase
Apre_0768	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Apre_0770	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Apre_0771	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Apre_0775	ENOG4108TGR	phosphatase
Apre_0780	ENOG4105CXT	aspartate transcarbamylase
Apre_0781	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
Apre_0784	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Apre_0785	ENOG4107W93	Dihydroorotate dehydrogenase
Apre_0786	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Apre_0790	ENOG4105C6E	dna polymerase iii
Apre_0791	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Apre_0792	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Apre_0795	ENOG4105VTR	Integrase
Apre_0797	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Apre_0811	ENOG4108UUM	single-stranded DNA-binding protein
Apre_0823	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Apre_0868	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Apre_0870	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Apre_0872	ENOG4108IUM	Glycogen debranching enzyme
Apre_0874	ENOG4105HZM	Fha domain containing protein
Apre_0876	ENOG4105CJN	penicillin-binding protein
Apre_0877	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Apre_0881	ENOG4105ETE	Transcriptional regulator (LacI family
Apre_0882	ENOG4105KRI	phosphocarrier protein (HPr
Apre_0883	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Apre_0886	ENOG4105QNR	S1 RNA binding domain protein
Apre_0887	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Apre_0888	ENOG4105CIN	aminoacyl-histidine dipeptidase
Apre_0893	ENOG4105C34	Pseudouridine synthase
Apre_0894	ENOG4105DKQ	ROK family
Apre_0895	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Apre_0896	ENOG4105BZU	Histidine kinase
Apre_0898	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Apre_0903	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Apre_0904	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Apre_0905	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Apre_0906	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Apre_0907	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Apre_0909	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Apre_0910	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Apre_0912	ENOG4105C5X	domain protein
Apre_0915	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Apre_0916	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Apre_0917	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Apre_0918	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Apre_0919	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
Apre_0921	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Apre_0922	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
Apre_0924	ENOG4105C3J	Cysteine desulfurase
Apre_0925	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Apre_0926	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Apre_0927	ENOG4105X36	(ribosomal) protein
Apre_0929	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Apre_0930	ENOG410812S	Rna-binding protein
Apre_0931	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Apre_0932	ENOG4108WF2	Metal Dependent Phosphohydrolase
Apre_0934	ENOG4105KQC	Competence protein
Apre_0935	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Apre_0936	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Apre_0937	ENOG4105VBH	UPF0297 protein
Apre_0940	ENOG41090R7	Ferric uptake
Apre_0941	ENOG4105CN5	Metallo-Beta-Lactamase
Apre_0942	ENOG4108VQJ	O-methyltransferase
Apre_0943	ENOG4105CFP	Peptidase U32
Apre_0945	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
Apre_0946	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Apre_0948	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Apre_0949	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Apre_0950	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Apre_0951	ENOG4105CXI	aluminum resistance protein
Apre_0952	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Apre_0953	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Apre_0954	ENOG4105D7W	serine acetyltransferase
Apre_0955	ENOG4105C6T	cysteine synthase
Apre_0956	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Apre_0957	ENOG4105CE9	30S ribosomal protein S2
Apre_0958	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Apre_0959	ENOG4105C25	Primosomal protein n'
Apre_0960	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Apre_0962	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Apre_0963	ENOG4105F23	Fibronectin-binding protein
Apre_0966	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Apre_0967	ENOG4108JA2	transcriptioN-repair coupling factor
Apre_0968	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Apre_0969	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Apre_0970	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Apre_0971	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
Apre_0972	ENOG4108YZG	isomerase
Apre_0973	ENOG4105DFU	Cell wall formation (By similarity)
Apre_0974	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
Apre_0976	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Apre_0977	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Apre_0978	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Apre_0979	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Apre_0980	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Apre_0981	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Apre_0982	ENOG4105C4R	Atp-dependent dna helicase
Apre_0983	ENOG4105KGF	protein, YerC YecD
Apre_0984	ENOG4105F1K	Glutamine amidotransferase
Apre_0985	ENOG4105DMS	mur ligase
Apre_0986	ENOG410855V	Acylphosphatase
Apre_0989	ENOG4105VBF	alkaline shock protein
Apre_0994	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Apre_0996	ENOG4108DBC	nitroreductase
Apre_0999	ENOG4108V0P	LemA family
Apre_1000	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
Apre_1001	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Apre_1002	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Apre_1004	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Apre_1005	ENOG4108KGH	TRANSCRIPTIONal
Apre_1006	ENOG4105CXN	decarboxylase
Apre_1010	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Apre_1011	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Apre_1014	ENOG410839E	ATP synthase, F0 subunit c
Apre_1015	ENOG4107WUB	V-type ATPase 116 kDa subunit
Apre_1018	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Apre_1019	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Apre_1022	ENOG4105CBX	hi0933 family
Apre_1023	ENOG4105FE9	pseudouridine synthase
Apre_1024	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Apre_1025	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Apre_1026	ENOG4108YZ4	nudix hydrolase
Apre_1027	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Apre_1028	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
Apre_1031	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Apre_1032	ENOG4105M7K	Involved in the transcription termination process (By similarity)
Apre_1034	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Apre_1035	ENOG4105CDE	UPF0348 protein
Apre_1037	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Apre_1038	ENOG4106H78	methyltransferase
Apre_1039	ENOG4105CB5	ATP-dependent DNA helicase recG
Apre_1040	ENOG4105DP4	dak2 domain fusion protein ylov
Apre_1043	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
Apre_1044	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Apre_1045	ENOG4105DC7	peptidase M24
Apre_1046	ENOG4105C3G	gtp-binding protein
Apre_1047	ENOG4107T8J	thymidine kinase
Apre_1050	ENOG4105ENA	helicase
Apre_1051	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Apre_1052	ENOG4108Z0Z	intracellular protease Pfpi family
Apre_1055	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Apre_1056	ENOG4105EPR	degv family
Apre_1058	ENOG41080E8	Transcriptional regulator, Spx MgsR family
Apre_1059	ENOG4105CH2	amidohydrolase
Apre_1062	ENOG4105C7B	Threonine dehydratase
Apre_1063	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Apre_1064	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
Apre_1065	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Apre_1068	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Apre_1069	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
Apre_1071	ENOG4108Z03	MAF-like protein
Apre_1072	ENOG4108Z86	Glutamine amidotransferase
Apre_1074	ENOG4108SGK	Tetr family transcriptional regulator
Apre_1077	ENOG4108MXD	gtp-binding protein
Apre_1079	ENOG4105DZ0	fad dependent oxidoreductase
Apre_1080	ENOG4105CMT	Dihydroxyacetone kinase
Apre_1082	ENOG4105VDH	Dihydroxyacetone kinase
Apre_1085	ENOG4107QHI	-hydrogenase
Apre_1086	ENOG4107QIZ	NADH dehydrogenase
Apre_1087	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
Apre_1091	ENOG4105C19	ABC transporter
Apre_1096	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
Apre_1099	ENOG4106YT9	Enoyl-CoA hydratase
Apre_1100	ENOG4105BZN	citrate synthase
Apre_1101	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Apre_1102	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Apre_1103	ENOG4107T2D	Phosphoribosylaminoimidazolesuccinocarboxamide synthase
Apre_1104	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Apre_1105	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Apre_1106	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Apre_1107	ENOG4107QNG	Phosphoribosylglycinamide synthetase
Apre_1108	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Apre_1109	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Apre_1111	ENOG4105CKU	formyltetrahydrofolate synthetase
Apre_1112	ENOG4105DZC	cytosine deaminase
Apre_1114	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Apre_1121	ENOG4108QEG	Membrane
Apre_1125	ENOG4105MA4	psp1 domain protein
Apre_1127	ENOG4105X0R	protein from nitrogen regulatory protein P-II
Apre_1128	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Apre_1129	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Apre_1130	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Apre_1131	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Apre_1135	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Apre_1136	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Apre_1137	ENOG4105W4W	Transcriptional regulator
Apre_1140	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Apre_1141	ENOG4105HMI	Membrane
Apre_1142	ENOG4105CGZ	zinc metallopeptidase
Apre_1143	ENOG4105I3K	Ferric uptake regulator, Fur family
Apre_1144	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Apre_1145	ENOG4108VZM	50s ribosomal protein L10
Apre_1146	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Apre_1147	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Apre_1148	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Apre_1150	ENOG4105WDJ	50S ribosomal protein L33
Apre_1152	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Apre_1154	ENOG41060K3	Methyltransferase
Apre_1155	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Apre_1158	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Apre_1159	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Apre_1161	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Apre_1162	ENOG4105VCC	30S ribosomal protein S21
Apre_1163	ENOG4107YU2	histidine triad (hIT) protein
Apre_1164	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Apre_1165	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Apre_1166	ENOG4105CFG	Acts as a chaperone (By similarity)
Apre_1167	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Apre_1169	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Apre_1170	ENOG4105CSA	Coproporphyrinogen iii oxidase
Apre_1174	ENOG4108AEY	RNA polymerase sigma factor
Apre_1176	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Apre_1177	ENOG4105CSA	Coproporphyrinogen iii oxidase
Apre_1181	ENOG4108RG0	uracil-dna glycosylase
Apre_1182	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Apre_1184	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Apre_1186	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Apre_1197	ENOG4105C8T	Leucyl-tRNA synthetase
Apre_1198	ENOG4105C5S	asparaginyl-tRNA synthetase
Apre_1199	ENOG4105D1H	recombination factor protein RarA
Apre_1200	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Apre_1201	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Apre_1203	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Apre_1204	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Apre_1208	ENOG4108V6E	Cell division protein mraZ
Apre_1209	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Apre_1210	ENOG4105CDY	transcriptional regulatory protein
Apre_1211	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Apre_1212	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Apre_1215	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Apre_1216	ENOG4105EB3	Histidine kinase
Apre_1220	ENOG4107QRT	dEAD DEAH box helicase
Apre_1224	ENOG41067TZ	transcriptional regulator, MarR family
Apre_1226	ENOG4107RUE	extracellular solute-binding protein family 1
Apre_1227	ENOG4105D38	putrescine abc transporter
Apre_1228	ENOG4105F38	ABC transporter, permease
Apre_1229	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Apre_1231	ENOG4105CEM	UPF0597 protein
Apre_1232	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Apre_1234	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
Apre_1241	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Apre_1242	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Apre_1243	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Apre_1244	ENOG4105C26	Dehydrogenase
Apre_1245	ENOG4105C8J	)-transporter
Apre_1246	ENOG4105C8J	)-transporter
Apre_1249	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Apre_1251	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
Apre_1252	ENOG4107S2Z	UPF0761 membrane protein
Apre_1253	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Apre_1267	ENOG4107XU6	Glycosyl transferase (Group 1
Apre_1268	ENOG4105CPF	Cell wall formation (By similarity)
Apre_1269	ENOG4105D3Q	Sugar transferase
Apre_1270	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Apre_1271	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Apre_1273	ENOG4105CJR	Integral membrane protein (MviN
Apre_1274	ENOG4105CJR	Integral membrane protein (MviN
Apre_1275	ENOG4108KGH	TRANSCRIPTIONal
Apre_1280	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Apre_1281	ENOG4105DBI	uridine monophosphokinase
Apre_1282	ENOG4108JQ1	Dehydrogenase
Apre_1284	ENOG4108Z6B	deaminase
Apre_1285	ENOG4105DZ1	carboxypeptidase
Apre_1288	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Apre_1289	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Apre_1290	ENOG4105C79	DNA protecting protein DprA
Apre_1291	ENOG4105VFF	UPF0102 protein
Apre_1292	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Apre_1293	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Apre_1297	ENOG4108JJB	ABC transporter
Apre_1299	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Apre_1300	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Apre_1301	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Apre_1302	ENOG4105VB6	UPF0109 protein
Apre_1303	ENOG4105K5M	30s ribosomal protein S16
Apre_1309	ENOG4105CJ1	ABC, transporter
Apre_1311	ENOG41084X6	Modulates RecA activity (By similarity)
Apre_1312	ENOG4105VC4	domain protein
Apre_1313	ENOG4105C03	ribonuclease
Apre_1315	ENOG4105CJN	penicillin-binding protein
Apre_1317	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
Apre_1319	ENOG4105W5Q	DNA repair protein (RadC
Apre_1322	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
Apre_1323	ENOG4105DGN	Electron transport complex
Apre_1324	ENOG4105DZB	Electron transport complex
Apre_1326	ENOG4105D6A	Electron transport complex
Apre_1327	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Apre_1329	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Apre_1330	ENOG4105C2M	dna polymerase I
Apre_1335	ENOG4105C75	arginyL-tRNA synthetase
Apre_1336	ENOG4105C98	muts2 protein
Apre_1337	ENOG4105CFP	Peptidase U32
Apre_1339	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Apre_1340	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Apre_1341	ENOG4108RWN	rrna methyltransferase
Apre_1342	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Apre_1343	ENOG41084A0	50s ribosomal protein L35
Apre_1344	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Apre_1346	ENOG4105EPR	degv family
Apre_1348	ENOG4108Z66	YbaK ebsC protein
Apre_1350	ENOG4105CYC	Transferase
Apre_1351	ENOG4105CHU	acetyl-coa acetyltransferase
Apre_1352	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Apre_1353	ENOG4105E39	Enoyl-CoA hydratase
Apre_1354	ENOG4105C10	Electron transfer flavoprotein
Apre_1355	ENOG4105BZJ	Electron transfer flavoprotein
Apre_1356	ENOG4105C1G	acyl-Coa dehydrogenase
Apre_1357	ENOG4105CQB	FAD linked oxidase domain protein
Apre_1358	ENOG4105VAW	lrga family
Apre_1359	ENOG41067MG	lrgb family
Apre_1361	ENOG4108Z5V	transcriptional regulator, merr family
Apre_1362	ENOG4108YZ8	Superoxide reductase
Apre_1363	ENOG4105CUT	histidyl-tRNA synthetase
Apre_1365	ENOG4105BZ1	(ABC) transporter
Apre_1366	ENOG4105BZ1	(ABC) transporter
Apre_1370	ENOG4105CJR	Integral membrane protein (MviN
Apre_1374	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Apre_1375	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Apre_1376	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Apre_1378	ENOG4105C8U	phosphate abc transporter
Apre_1379	ENOG4107S17	Phosphate-binding protein
Apre_1381	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Apre_1382	ENOG41069H7	transport system small permease component
Apre_1383	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Apre_1388	ENOG410667J	hydrolase
Apre_1391	ENOG41090A1	ferritin
Apre_1393	ENOG4105WPN	DNA integration recombination invertion protein
Apre_1394	ENOG4108UJD	30S ribosomal protein S9
Apre_1395	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Apre_1397	ENOG4105DWF	phosphomethylpyrimidine kinase
Apre_1398	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Apre_1399	ENOG4105C1A	potassium transporter peripheral membrane
Apre_1400	ENOG4105DFD	Na H antiporter
Apre_1403	ENOG4105N5T	Radical SAM Protein
Apre_1404	ENOG4105DCF	alanine dehydrogenase
Apre_1406	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Apre_1407	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Apre_1408	ENOG4105KTU	Transcriptional regulator, arsr family
Apre_1410	ENOG4105C59	p-type ATPase
Apre_1413	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Apre_1416	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Apre_1417	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Apre_1418	ENOG4108JJB	ABC transporter
Apre_1419	ENOG4108JJB	ABC transporter
Apre_1421	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Apre_1422	ENOG4108UTP	(2Fe-2S)-binding domain protein
Apre_1423	ENOG4108HR6	Dehydrogenase
Apre_1424	ENOG4105C7W	Xanthine dehydrogenase
Apre_1427	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Apre_1428	ENOG4105BZ8	glutamate synthase
Apre_1429	ENOG4105C5B	carbamate kinase
Apre_1432	ENOG4107S4Y	M20 DapE family protein YgeY
Apre_1433	ENOG4105IW6	Carbamoyltransferase
Apre_1434	ENOG4107RCH	Diaminopropionate ammonia-lyase
Apre_1435	ENOG4108WYP	Transcriptional regulator
Apre_1436	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Apre_1439	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Apre_1440	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Apre_1441	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Apre_1442	ENOG4105E0C	molybdate abc transporter
Apre_1443	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Apre_1444	ENOG4105CU9	asparagine synthetase A
Apre_1456	ENOG4108Z29	Flavodoxin
Apre_1464	ENOG4105VBF	alkaline shock protein
Apre_1467	ENOG4105C5H	ABC transporter
Apre_1468	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
Apre_1470	ENOG4105CI3	gtp-binding protein typa
Apre_1472	ENOG4105VCQ	rubredoxin
Apre_1473	ENOG4105VCQ	rubredoxin
Apre_1478	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Apre_1480	ENOG4105CZV	ABC transporter
Apre_1491	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Apre_1492	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
Apre_1493	ENOG4105D3Q	Sugar transferase
Apre_1494	ENOG4105I08	Pseudouridine synthase
Apre_1495	ENOG4105K7K	Transcriptional regulator
Apre_1496	ENOG4105C4R	Atp-dependent dna helicase
Apre_1498	ENOG4108IFG	nitrite reductase, (NAD(P)H)
Apre_1500	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Apre_1501	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Apre_1503	ENOG4105E0X	reductase
Apre_1505	ENOG4105CBX	hi0933 family
Apre_1506	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Apre_1509	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Apre_1511	ENOG4105F8V	Hydrolase, tatD family
Apre_1512	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Apre_1513	ENOG4105BZG	amino acid carrier protein
Apre_1514	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Apre_1518	ENOG4105BZ1	(ABC) transporter
Apre_1519	ENOG4105WH1	Two component transcriptional regulator luxr family
Apre_1523	ENOG4105C2J	ABC transporter
Apre_1532	ENOG4105E5Q	amino acid AbC transporter
Apre_1538	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Apre_1540	ENOG4105C5Y	PTS System
Apre_1541	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Apre_1543	ENOG4107S1E	Beta-lactamase
Apre_1544	ENOG4106G6Q	Transcriptional regulator
Apre_1545	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
Apre_1546	ENOG4108ZT0	50S ribosomal protein l17
Apre_1547	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Apre_1548	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Apre_1549	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Apre_1550	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Apre_1551	ENOG41067V7	50S ribosomal protein L36
Apre_1552	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Apre_1553	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Apre_1555	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Apre_1556	ENOG4105VPB	50S ribosomal protein L30
Apre_1557	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Apre_1559	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Apre_1560	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Apre_1561	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Apre_1562	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Apre_1563	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Apre_1564	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Apre_1565	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Apre_1566	ENOG41082SA	50s ribosomal protein l29
Apre_1567	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Apre_1568	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Apre_1569	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Apre_1570	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Apre_1571	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Apre_1572	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Apre_1573	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Apre_1574	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Apre_1575	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Apre_1576	ENOG4105CSR	polyphosphate kinase 2
Apre_1578	ENOG4105DFD	Na H antiporter
Apre_1583	ENOG4105CK1	PTS System
Apre_1584	ENOG4105CS2	ec 3.2.1.21
Apre_1585	ENOG4105VZJ	PTS System
Apre_1586	ENOG4105VCP	PTS System
Apre_1588	ENOG4105CTQ	phosphohexokinase
Apre_1590	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
Apre_1592	ENOG4105CT4	transporter
Apre_1593	ENOG4105CT4	transporter
Apre_1594	ENOG4105D9R	oxidoreductase
Apre_1596	ENOG4105CK5	oxidoreductase
Apre_1597	ENOG4105CK5	oxidoreductase
Apre_1599	ENOG4108UHU	Aldolase
Apre_1600	ENOG4105D2H	Uronic isomerase
Apre_1601	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
Apre_1602	ENOG4105DEI	Mannitol dehydrogenase
Apre_1603	ENOG4105CG3	alpha amylase, catalytic region
Apre_1605	ENOG4105QUH	Domain of unknown function (DUF2088)
Apre_1606	ENOG4105CAH	Chromate
Apre_1608	ENOG4105CNT	hydrolase family 2
Apre_1611	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Apre_1612	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
Apre_1613	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
Apre_1614	ENOG4105CPQ	Dehydrogenase
Apre_1617	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Apre_1618	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
Apre_1619	ENOG4105CNN	ABC, transporter
Apre_1620	ENOG4105C2J	ABC transporter
Apre_1621	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
Apre_1624	ENOG4105C87	Aminotransferase class I and II
Apre_1625	ENOG4105RD7	BadF BadG BcrA BcrD
Apre_1626	ENOG41084DH	Dihydrofolate reductase
Apre_1628	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Apre_1632	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Apre_1633	ENOG4105D06	uba thif-type nad fad binding protein
Apre_1636	ENOG4108UNV	SUF system FeS assembly protein, NifU family
Apre_1638	ENOG4105JRK	feS assembly protein SufD
Apre_1640	ENOG4105C3K	feS assembly ATPase SufC
Apre_1641	ENOG410849S	phosphocarrier protein (HPr)
Apre_1642	ENOG4105WVZ	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Apre_1643	ENOG4105M0M	Tetracycline resistance protein
Apre_1645	ENOG4105C8N	cysteinyl-tRNA synthetase
Apre_1646	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Apre_1648	ENOG4105DPN	Oligoendopeptidase f
Apre_1655	ENOG4105VZ8	Transcriptional regulator
Apre_1656	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
Apre_1658	ENOG4107QYV	phosphohexose isomerase
Apre_1662	ENOG4105C3S	Mate efflux family protein
Apre_1664	ENOG4105C22	threonyL-tRNA synthetase
Apre_1667	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
Apre_1669	ENOG4105CT8	Phosphorylase
Apre_1672	ENOG4105CMR	udp-glucose 4-epimerase
Apre_1674	ENOG4105ESP	cell wall surface anchor family protein
Apre_1675	ENOG4108RG5	PTS system N-acetylgalactosamine-specific transporter subunit IIB
Apre_1676	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Apre_1677	ENOG4108YYH	Nadph-dependent fmn reductase
Apre_1678	ENOG4105EUB	pirin domain protein
Apre_1679	ENOG4105K56	Transcriptional regulator
Apre_1681	ENOG4105EPD	Oligopeptide transporter, Opt family
Apre_1682	ENOG4105C37	(CBS) domain
Apre_1683	ENOG4107S6Z	Na H antiporter
Apre_1684	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Apre_1685	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Apre_1686	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Apre_1687	ENOG4105KXQ	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Apre_1694	ENOG4108KMV	Glycosyl transferase (Group 1
Apre_1695	ENOG4105BZG	amino acid carrier protein
Apre_1696	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Apre_1697	ENOG41082T9	Membrane
Apre_1700	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Apre_1701	ENOG4105VK3	rdd domain containing protein
Apre_1705	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
Apre_1706	ENOG4105C8M	UPF0272 protein
Apre_1707	ENOG4105C8M	UPF0272 protein
Apre_1709	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
Apre_1710	ENOG4108HWH	(ABC) transporter
Apre_1717	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Apre_1718	ENOG4105K56	Transcriptional regulator
Apre_1720	ENOG4105C3M	thioredoxin reductase
Apre_1727	ENOG4105FA0	parb-like partition protein
Apre_1728	ENOG4107QJE	Chromosome Partitioning Protein
Apre_1729	ENOG4105CEV	competence damage-inducible protein
Apre_1731	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Apre_1732	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Apre_1733	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Apre_1736	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Apre_1737	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Apre_1738	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Apre_1743	ENOG4105BZ1	(ABC) transporter
Apre_1744	ENOG4105CJA	serine threonine protein kinase
Apre_1745	ENOG4108JJB	ABC transporter
Apre_1757	ENOG4108JJA	ABC, transporter
Apre_1758	ENOG4105MU5	relaxase mobilization nuclease domain protein
Apre_1763	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
Apre_1764	ENOG4105C0W	non-ribosomal peptide synthetase
Apre_1769	ENOG4105C3U	ABC transporter
Apre_1770	ENOG4108JQ7	(ABC) transporter
Apre_1771	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
Apre_1773	ENOG4105BZ1	(ABC) transporter
Apre_1774	ENOG4105BZ1	(ABC) transporter
Apre_1777	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Apre_1781	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Apre_1783	ENOG4108I0C	methyltransferase
Apre_1790	ENOG41086D8	Transcriptional regulator
Apre_1795	ENOG4108C33	Resolvase
Apre_1798	ENOG41086D8	Transcriptional regulator
Apre_1822	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Apre_1825	ENOG4105EKQ	RNA-directed DNA polymerase
Apre_1830	ENOG4105VMP	Transcriptional regulator
Apre_1845	ENOG4105C2J	ABC transporter
Apre_1849	ENOG4105WH1	Two component transcriptional regulator luxr family