locus-tag	class	description
I6H45_00010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H45_00010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H45_00015	COG2207	Transcriptional regulator
I6H45_00015	COG4753	response regulator
I6H45_00020	COG2972	Histidine kinase
I6H45_00030	COG2252	PERMEase
I6H45_00035	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6H45_00055	COG1757	Na H antiporter
I6H45_00060	COG0583	DNA-binding transcription factor activity
I6H45_00120	COG1640	4-alpha-glucanotransferase
I6H45_00125	COG3842	ATPase activity
I6H45_00130	COG0534	Mate efflux family protein
I6H45_00135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H45_00170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H45_00175	COG0569	domain protein
I6H45_00180	COG2738	Putative neutral zinc metallopeptidase
I6H45_00185	COG4463	regulation of RNA biosynthetic process
I6H45_00200	COG0542	response to heat
I6H45_00225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H45_00230	COG1121	(ABC) transporter
I6H45_00260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H45_00275	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H45_00280	COG1609	Transcriptional regulator
I6H45_00295	COG1129	ABC transporter
I6H45_00300	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H45_00305	COG1879	ABC-type sugar transport system periplasmic component
I6H45_00315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H45_00320	COG3716	PTS system mannose fructose sorbose family IID component
I6H45_00330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H45_00335	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6H45_00340	COG1737	Transcriptional regulator
I6H45_00345	COG4221	oxidoreductase activity
I6H45_00350	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H45_00355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H45_00375	COG0438	transferase activity, transferring glycosyl groups
I6H45_00405	COG1725	Transcriptional regulator
I6H45_00410	COG1131	(ABC) transporter
I6H45_00420	COG1482	cell wall glycoprotein biosynthetic process
I6H45_00430	COG1597	lipid kinase activity
I6H45_00440	COG4956	integral membrane protein (PIN domain superfamily)
I6H45_00445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H45_00450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H45_00455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H45_00460	COG1077	Cell shape determining protein MreB Mrl
I6H45_00465	COG0588	phosphoglycerate mutase activity
I6H45_00485	COG0385	Bile acid
I6H45_00490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H45_00495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6H45_00530	COG1518	maintenance of DNA repeat elements
I6H45_00535	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H45_00580	COG2217	Heavy metal translocating P-type atpase
I6H45_00600	COG0464	growth
I6H45_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H45_00610	COG0215	cysteine-tRNA ligase activity
I6H45_00615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H45_00625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H45_00650	COG4152	abc transporter atp-binding protein
I6H45_00665	COG1573	uracil-dna glycosylase
I6H45_00685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H45_00690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H45_00700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H45_00705	COG0037	tRNA processing
I6H45_00710	COG1968	undecaprenyl-diphosphatase activity
I6H45_00730	COG1725	Transcriptional regulator
I6H45_00735	COG1129	ABC transporter
I6H45_00735	COG0842	Transport permease protein
I6H45_00745	COG0598	Magnesium transport protein CorA
I6H45_00755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H45_00760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H45_00765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H45_00765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H45_00765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H45_00780	COG1070	Carbohydrate kinase
I6H45_00785	COG1461	Dihydroxyacetone kinase
I6H45_00790	COG3853	Toxic anion resistance protein (TelA)
I6H45_00810	COG3715	PTS system
I6H45_00815	COG3716	PTS system mannose fructose sorbose family IID component
I6H45_00825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H45_00840	COG0668	transmembrane transport
I6H45_00845	COG4481	Protein conserved in bacteria
I6H45_00970	COG0569	domain protein
I6H45_00980	COG1811	Na channel or pump
I6H45_00985	COG0352	thiamine-phosphate diphosphorylase activity
I6H45_00985	COG0351	phosphomethylpyrimidine kinase
I6H45_01005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H45_01010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H45_01020	COG2059	Chromate
I6H45_01025	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H45_01035	COG1528	Iron-storage protein
I6H45_01055	COG0561	phosphatase activity
I6H45_01065	COG4509	Sortase family
I6H45_01075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H45_01125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H45_01130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H45_01130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H45_01130	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H45_01130	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H45_01135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H45_01140	COG1473	amidohydrolase
I6H45_01145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H45_01150	COG2011	ABC-type metal ion transport system permease component
I6H45_01170	COG0210	DNA helicase
I6H45_01180	COG1187	pseudouridine synthase activity
I6H45_01185	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6H45_01200	COG3634	alkyl hydroperoxide reductase activity
I6H45_01210	COG2963	transposase activity
I6H45_01215	COG2801	Transposase and inactivated derivatives
I6H45_01230	COG0601	transmembrane transport
I6H45_01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H45_01240	COG0444	Belongs to the ABC transporter superfamily
I6H45_01245	COG4608	Belongs to the ABC transporter superfamily
I6H45_01250	COG4166	transmembrane transport
I6H45_01265	COG1136	(ABC) transporter
I6H45_01280	COG0579	oxidoreductase
I6H45_01285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H45_01290	COG1363	Peptidase, m42
I6H45_01295	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H45_01300	COG3845	ABC transporter
I6H45_01305	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H45_01310	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H45_01340	COG1131	(ABC) transporter
I6H45_01360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H45_01375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H45_01380	COG1442	glycosyl transferase family 8
I6H45_01400	COG1217	gtp-binding protein TYPA
I6H45_01415	COG0488	(ABC) transporter
I6H45_01435	COG1393	Belongs to the ArsC family
I6H45_01455	COG0058	SHG alpha-glucan phosphorylase activity
I6H45_01465	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6H45_01485	COG0740	serine-type endopeptidase activity
I6H45_01490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H45_01495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H45_01500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H45_01510	COG1362	aminopeptidase activity
I6H45_01515	COG0011	TIGRFAM Protein of
I6H45_01520	COG2252	PERMEase
I6H45_01525	COG4536	flavin adenine dinucleotide binding
I6H45_01535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6H45_01540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H45_01545	COG1605	Chorismate mutase
I6H45_01545	COG0077	Prephenate dehydratase
I6H45_01555	COG1115	amino acid carrier protein
I6H45_01575	COG1362	aminopeptidase activity
I6H45_01590	COG0534	Mate efflux family protein
I6H45_01595	COG0351	phosphomethylpyrimidine kinase
I6H45_01600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H45_01605	COG2186	Transcriptional regulator
I6H45_01610	COG1131	(ABC) transporter
I6H45_01620	COG2131	deaminase
I6H45_01670	COG0051	transcription antitermination factor activity, RNA binding
I6H45_01675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H45_01680	COG0088	Forms part of the polypeptide exit tunnel
I6H45_01685	COG0089	rRNA binding
I6H45_01690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H45_01695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H45_01700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H45_01705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H45_01710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H45_01715	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H45_01720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H45_01725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H45_01730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H45_01735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H45_01740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H45_01745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H45_01750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H45_01755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H45_01760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H45_01765	COG1841	ribosomal large subunit assembly
I6H45_01770	COG0200	Binds to the 23S rRNA
I6H45_01780	COG0563	adenylate kinase activity
I6H45_01785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H45_01790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H45_01795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H45_01800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H45_01805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H45_01810	COG0202	RNA polymerase activity
I6H45_01815	COG0203	ribosomal protein L17
I6H45_01840	COG0205	6-phosphofructokinase activity
I6H45_01855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H45_01865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H45_01870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6H45_01880	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6H45_01895	COG0085	RNA polymerase activity
I6H45_01900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H45_01910	COG2116	formate transmembrane transporter activity
I6H45_01925	COG3383	formate dehydrogenase (NAD+) activity
I6H45_01930	COG3383	formate dehydrogenase (NAD+) activity
I6H45_01945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H45_01950	COG0303	'Molybdopterin
I6H45_01955	COG0303	'Molybdopterin
I6H45_01980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H45_01985	COG0049	tRNA binding
I6H45_01990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H45_01995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H45_02015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H45_02020	COG1971	Probably functions as a manganese efflux pump
I6H45_02030	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H45_02045	COG0138	bifunctional purine biosynthesis protein purh
I6H45_02050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H45_02055	COG0516	GMP reductase activity
I6H45_02055	COG0517	IMP dehydrogenase activity
I6H45_02065	COG1346	cytolysis
I6H45_02070	COG1380	Effector of murein hydrolase LrgA
I6H45_02075	COG0277	FAD linked oxidase domain protein
I6H45_02080	COG1960	acyl-CoA dehydrogenase activity
I6H45_02090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6H45_02095	COG0427	acetyl-CoA hydrolase
I6H45_02100	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H45_02105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H45_02110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H45_02115	COG1876	peptidase activity
I6H45_02120	COG0728	peptidoglycan biosynthetic process
I6H45_02160	COG0410	ABC transporter
I6H45_02175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H45_02185	COG0346	lactoylglutathione lyase activity
I6H45_02210	COG0124	histidyl-tRNA synthetase
I6H45_02215	COG1307	EDD domain protein, DegV family
I6H45_02230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H45_02230	COG3711	transcriptional antiterminator
I6H45_02275	COG1307	EDD domain protein, DegV family
I6H45_02280	COG2033	superoxide reductase activity
I6H45_02285	COG0116	Belongs to the methyltransferase superfamily
I6H45_02300	COG1122	ATPase activity
I6H45_02305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H45_02310	COG0101	tRNA pseudouridine synthase activity
I6H45_02320	COG0514	ATP-dependent DNA helicase (RecQ)
I6H45_02335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H45_02340	COG0573	inorganic phosphate transmembrane transporter activity
I6H45_02345	COG0581	inorganic phosphate transmembrane transporter activity
I6H45_02350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H45_02355	COG0704	Plays a role in the regulation of phosphate uptake
I6H45_02360	COG0745	RESPONSE REGULATOR receiver
I6H45_02365	COG5002	protein histidine kinase activity
I6H45_02385	COG1960	acyl-CoA dehydrogenase activity
I6H45_02395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H45_02395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H45_02400	COG1408	metallophosphoesterase
I6H45_02430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H45_02435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6H45_02440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H45_02445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H45_02450	COG0151	Belongs to the GarS family
I6H45_02455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H45_02460	COG1301	dicarboxylic acid transport
I6H45_02470	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H45_02475	COG1121	(ABC) transporter
I6H45_02480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H45_02485	COG3022	response to hydroperoxide
I6H45_02490	COG0420	3'-5' exonuclease activity
I6H45_02505	COG1074	ATP-dependent DNA helicase activity
I6H45_02510	COG1028	Short-chain dehydrogenase reductase Sdr
I6H45_02515	COG0656	L-ascorbic acid biosynthetic process
I6H45_02525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H45_02545	COG0493	'glutamate synthase
I6H45_02555	COG1132	(ABC) transporter
I6H45_02560	COG0484	heat shock protein binding
I6H45_02575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H45_02575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H45_02590	COG1104	cysteine desulfurase activity
I6H45_02595	COG0482	sulfurtransferase activity
I6H45_02605	COG0606	chelatase, subunit chli
I6H45_02610	COG0564	pseudouridine synthase activity
I6H45_02620	COG4589	Belongs to the CDS family
I6H45_02625	COG0750	zinc metalloprotease
I6H45_02640	COG0697	spore germination
I6H45_02645	COG0779	Required for maturation of 30S ribosomal subunits
I6H45_02650	COG0195	Participates in both transcription termination and antitermination
I6H45_02655	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H45_02660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H45_02665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H45_02670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H45_02675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H45_02680	COG0196	riboflavin kinase activity
I6H45_02690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H45_02695	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H45_02705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H45_02710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H45_02715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H45_02720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H45_02735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H45_02745	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6H45_02750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H45_02755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H45_02760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H45_02775	COG1484	DNA-dependent DNA replication
I6H45_02810	COG1132	(ABC) transporter
I6H45_02815	COG1132	(ABC) transporter
I6H45_02820	COG1129	ABC transporter
I6H45_02930	COG0551	DNA topoisomerase type I activity
I6H45_02930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H45_02960	COG0745	RESPONSE REGULATOR receiver
I6H45_02965	COG2205	protein histidine kinase activity
I6H45_03005	COG0577	efflux transmembrane transporter activity
I6H45_03005	COG1136	(ABC) transporter
I6H45_03105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H45_03105	COG0551	DNA topoisomerase type I activity
I6H45_03135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H45_03145	COG4555	ABC transporter
I6H45_03160	COG3843	relaxase mobilization nuclease domain protein
I6H45_03175	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6H45_03180	COG2091	lysine biosynthetic process via aminoadipic acid
I6H45_03185	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6H45_03190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H45_03190	COG2226	methyltransferase
I6H45_03190	COG3433	isochorismatase activity
I6H45_03240	COG2375	cellular response to nickel ion
I6H45_03240	COG1132	(ABC) transporter
I6H45_03245	COG1132	(ABC) transporter
I6H45_03260	COG1129	ABC transporter
I6H45_03265	COG0534	Mate efflux family protein
I6H45_03300	COG1136	(ABC) transporter
I6H45_03330	COG1136	(ABC) transporter
I6H45_03340	COG3843	relaxase mobilization nuclease domain protein
I6H45_03370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H45_03370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H45_03385	COG0215	cysteine-tRNA ligase activity
I6H45_03390	COG1131	(ABC) transporter
I6H45_03405	COG0745	RESPONSE REGULATOR receiver
I6H45_03410	COG5002	protein histidine kinase activity
I6H45_03445	COG1131	(ABC) transporter
I6H45_03465	COG2094	Belongs to the DNA glycosylase MPG family
I6H45_03470	COG1597	lipid kinase activity
I6H45_03480	COG0733	neurotransmitter:sodium symporter activity
I6H45_03485	COG0733	neurotransmitter:sodium symporter activity
I6H45_03490	COG2843	Capsule synthesis protein
I6H45_03495	COG0671	phosphoesterase, PA-phosphatase related
I6H45_03505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H45_03505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H45_03510	COG0237	dephospho-CoA kinase activity
I6H45_03515	COG0741	lytic transglycosylase activity
I6H45_03520	COG4656	Part of a membrane complex involved in electron transport
I6H45_03525	COG4658	electron transport chain
I6H45_03535	COG4660	Part of a membrane complex involved in electron transport
I6H45_03540	COG4657	Part of a membrane complex involved in electron transport
I6H45_03545	COG2878	Part of a membrane complex involved in electron transport
I6H45_03545	COG1245	4Fe-4S binding domain
I6H45_03560	COG2003	Belongs to the UPF0758 family
I6H45_03570	COG1792	Involved in formation and maintenance of cell shape
I6H45_03580	COG0768	penicillin binding
I6H45_03590	COG1530	ribonuclease E activity
I6H45_03600	COG2137	regulation of response to DNA damage stimulus
I6H45_03615	COG1131	(ABC) transporter
I6H45_03630	COG0528	UMP kinase activity
I6H45_03635	COG0233	cytoplasmic translational termination
I6H45_03640	COG1459	type II secretion system
I6H45_03675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H45_03680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H45_03685	COG0416	fatty acid biosynthetic process
I6H45_03690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H45_03695	COG0571	ribonuclease III activity
I6H45_03710	COG0242	peptide deformylase activity
I6H45_03715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H45_03720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H45_03720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H45_03725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H45_03735	COG0515	serine threonine protein kinase
I6H45_03735	COG2815	serine threonine protein kinase
I6H45_03745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H45_03750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H45_03755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H45_03760	COG1660	Displays ATPase and GTPase activities
I6H45_03770	COG1481	regulation of sporulation
I6H45_03775	COG0587	DNA-directed DNA polymerase activity
I6H45_03780	COG0205	6-phosphofructokinase activity
I6H45_03790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H45_03845	COG0745	RESPONSE REGULATOR receiver
I6H45_03855	COG0577	efflux transmembrane transporter activity
I6H45_03855	COG1136	(ABC) transporter
I6H45_03865	COG0433	COG0433 Predicted ATPase
I6H45_03880	COG1132	(ABC) transporter
I6H45_03885	COG1132	(ABC) transporter
I6H45_03900	COG1129	ABC transporter
I6H45_03955	COG0484	heat shock protein binding
I6H45_03965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H45_03965	COG1328	CTP reductase activity
I6H45_03970	COG0602	queuosine metabolic process
I6H45_03995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H45_04030	COG1309	transcriptional regulator
I6H45_04045	COG0444	Belongs to the ABC transporter superfamily
I6H45_04050	COG4608	Belongs to the ABC transporter superfamily
I6H45_04055	COG0747	negative chemotaxis
I6H45_04060	COG2375	cellular response to nickel ion
I6H45_04060	COG1132	(ABC) transporter
I6H45_04100	COG2190	(PTS) system
I6H45_04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H45_04100	COG1263	PTS System
I6H45_04110	COG2188	Transcriptional regulator
I6H45_04125	COG1395	domain, Protein
I6H45_04140	COG1401	restriction endodeoxyribonuclease activity
I6H45_04260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H45_04260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H45_04265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H45_04280	COG0716	FMN binding
I6H45_04285	COG2376	Dihydroxyacetone kinase
I6H45_04300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H45_04305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H45_04310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H45_04320	COG0398	Pfam SNARE associated Golgi protein
I6H45_04345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H45_04355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H45_04360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H45_04370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H45_04375	COG0081	regulation of translation
I6H45_04380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H45_04385	COG0222	ribosome binding
I6H45_04400	COG0285	dihydrofolate synthase activity
I6H45_04405	COG1288	antiporter activity
I6H45_04410	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H45_04415	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H45_04420	COG2801	Transposase and inactivated derivatives
I6H45_04425	COG2963	transposase activity
I6H45_04435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H45_04440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H45_04445	COG0297	glycogen (starch) synthase activity
I6H45_04450	COG0058	SHG alpha-glucan phosphorylase activity
I6H45_04455	COG1523	belongs to the glycosyl hydrolase 13 family
I6H45_04460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H45_04480	COG0768	penicillin binding
I6H45_04485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H45_04490	COG0564	pseudouridine synthase activity
I6H45_04520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H45_04530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H45_04540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H45_04570	COG0564	pseudouridine synthase activity
I6H45_04585	COG0745	RESPONSE REGULATOR receiver
I6H45_04590	COG5002	protein histidine kinase activity
I6H45_04600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H45_04625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H45_04630	COG0632	four-way junction helicase activity
I6H45_04635	COG2255	four-way junction helicase activity
I6H45_04655	COG1115	amino acid carrier protein
I6H45_04660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H45_04660	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H45_04665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H45_04670	COG1490	D-aminoacyl-tRNA deacylase activity
I6H45_04675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H45_04680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H45_04690	COG1160	GTP binding
I6H45_04695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H45_04700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H45_04705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H45_04710	COG1799	cell septum assembly
I6H45_04715	COG2302	S4 RNA-binding domain
I6H45_04735	COG1104	cysteine desulfurase activity
I6H45_04740	COG0301	tRNA thio-modification
I6H45_04745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H45_04750	COG2868	ribosomal protein
I6H45_04755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H45_04760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H45_04765	COG1534	Rna-binding protein
I6H45_04770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H45_04775	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H45_04780	COG0799	negative regulation of ribosome biogenesis
I6H45_04785	COG1555	photosystem II stabilization
I6H45_04785	COG1596	polysaccharide export
I6H45_04790	COG1959	2 iron, 2 sulfur cluster binding
I6H45_04795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H45_04800	COG4472	Bacterial protein of unknown function (DUF965)
I6H45_04820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6H45_04825	COG4122	O-methyltransferase activity
I6H45_04830	COG0826	peptidase U32
I6H45_04845	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H45_04850	COG0756	dUTP diphosphatase activity
I6H45_04860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H45_04865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H45_04870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H45_04875	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6H45_04880	COG4974	Belongs to the 'phage' integrase family
I6H45_04885	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H45_04885	COG1388	LysM domain
I6H45_04890	COG1418	mRNA catabolic process
I6H45_04895	COG1132	(ABC) transporter
I6H45_04900	COG1132	(ABC) transporter
I6H45_04905	COG1045	serine acetyltransferase
I6H45_04910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H45_04915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H45_04920	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H45_04925	COG0552	protein localization to endoplasmic reticulum
I6H45_04930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H45_04935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H45_04940	COG1758	RNA polymerase activity
I6H45_04945	COG0194	GDP metabolic process
I6H45_04955	COG0776	regulation of translation
I6H45_04965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H45_04970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H45_04975	COG0193	aminoacyl-tRNA hydrolase activity
I6H45_04985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H45_04995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H45_05000	COG0698	ribose 5-phosphate isomerase
I6H45_05015	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6H45_05025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H45_05025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H45_05030	COG0402	S-adenosylhomocysteine deaminase activity
I6H45_05035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H45_05045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H45_05050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H45_05060	COG4496	protein, YerC YecD
I6H45_05065	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6H45_05070	COG3442	glutamine amidotransferase
I6H45_05075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H45_05085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H45_05090	COG0167	dihydroorotate dehydrogenase activity
I6H45_05095	COG0543	2 iron, 2 sulfur cluster binding
I6H45_05100	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H45_05115	COG0540	Belongs to the ATCase OTCase family
I6H45_05140	COG0588	phosphoglycerate mutase activity
I6H45_05150	COG1136	(ABC) transporter
I6H45_05155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H45_05160	COG0557	exoribonuclease II activity
I6H45_05170	COG0148	phosphopyruvate hydratase activity
I6H45_05175	COG0149	triose-phosphate isomerase activity
I6H45_05180	COG0126	phosphoglycerate kinase activity
I6H45_05195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H45_05200	COG0561	phosphatase activity
I6H45_05205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H45_05210	COG0772	Belongs to the SEDS family
I6H45_05215	COG4475	Protein of unknown function (DUF436)
I6H45_05250	COG1269	ATP hydrolysis coupled proton transport
I6H45_05265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H45_05270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H45_05270	COG0539	negative regulation of cytoplasmic translation
I6H45_05275	COG0204	Acyl-transferase
I6H45_05280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H45_05285	COG2081	HI0933 family
I6H45_05290	COG1187	pseudouridine synthase activity
I6H45_05295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H45_05300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H45_05305	COG1051	belongs to the nudix hydrolase family
I6H45_05310	COG0497	DNA recombination
I6H45_05315	COG1438	arginine binding
I6H45_05335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H45_05345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H45_05350	COG1323	Belongs to the UPF0348 family
I6H45_05365	COG0742	ribosomal rna small subunit methyltransferase
I6H45_05385	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H45_05385	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H45_05385	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H45_05385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H45_05395	COG0322	excinuclease ABC activity
I6H45_05400	COG0006	proline dipeptidase activity
I6H45_05405	COG0012	GTP binding
I6H45_05415	COG0183	Belongs to the thiolase family
I6H45_05420	COG1114	Component of the transport system for branched-chain amino acids
I6H45_05425	COG0024	Methionine aminopeptidase
I6H45_05430	COG0778	Nitroreductase
I6H45_05435	COG0210	DNA helicase
I6H45_05440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H45_05450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H45_05455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H45_05460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H45_05485	COG1917	Cupin 2, conserved barrel domain protein
I6H45_05485	COG2207	Transcriptional regulator
I6H45_05500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H45_05520	COG1774	PSP1 C-terminal conserved region
I6H45_05530	COG3870	Protein conserved in bacteria
I6H45_05535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H45_05540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H45_05545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H45_05555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H45_05570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H45_05575	COG2384	SAM-dependent methyltransferase
I6H45_05580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H45_05580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H45_05585	COG0358	DNA primase activity
I6H45_05590	COG1012	belongs to the aldehyde dehydrogenase family
I6H45_05595	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H45_05600	COG1950	PFAM Membrane protein of
I6H45_05605	COG1254	Belongs to the acylphosphatase family
I6H45_05610	COG2217	Heavy metal translocating P-type atpase
I6H45_05645	COG0039	L-malate dehydrogenase activity
I6H45_05650	COG0494	nUDIX hydrolase
I6H45_05670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H45_05685	COG5522	Integral membrane protein (intg_mem_TP0381)
I6H45_05705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H45_05710	COG0537	adenosine 5'-monophosphoramidase activity
I6H45_05715	COG1114	Component of the transport system for branched-chain amino acids
I6H45_05730	COG1597	lipid kinase activity
I6H45_05735	COG0708	Exodeoxyribonuclease III
I6H45_05740	COG2321	neutral zinc metallopeptidase
I6H45_05745	COG0640	Transcriptional regulator
I6H45_05755	COG2217	Heavy metal translocating P-type atpase
I6H45_05760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H45_05765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6H45_05775	COG0039	L-malate dehydrogenase activity
I6H45_05780	COG1115	amino acid carrier protein
I6H45_05785	COG1757	Na H antiporter
I6H45_05790	COG1115	amino acid carrier protein
I6H45_05800	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6H45_05820	COG1757	Na H antiporter
I6H45_05830	COG1132	(ABC) transporter
I6H45_05865	COG1316	TRANSCRIPTIONal
I6H45_05880	COG1982	Orn Lys Arg decarboxylase major
I6H45_05900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H45_05905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H45_05910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H45_05915	COG0009	L-threonylcarbamoyladenylate synthase
I6H45_05920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H45_05925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H45_05930	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H45_05935	COG0254	rRNA binding
I6H45_05945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H45_05960	COG0442	prolyl-tRNA aminoacylation
I6H45_05965	COG2190	(PTS) system
I6H45_05970	COG2183	response to ionizing radiation
I6H45_05990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H45_05995	COG0484	heat shock protein binding
I6H45_06000	COG0443	Heat shock 70 kDa protein
I6H45_06010	COG1420	regulation of RNA biosynthetic process
I6H45_06015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H45_06020	COG0481	GTPase activity
I6H45_06025	COG0681	Belongs to the peptidase S26 family
I6H45_06030	COG0268	Binds directly to 16S ribosomal RNA
I6H45_06050	COG0495	leucyl-tRNA aminoacylation
I6H45_06060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H45_06065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H45_06070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H45_06080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H45_06085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H45_06090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H45_06100	COG0275	rRNA processing
I6H45_06105	COG2001	Belongs to the MraZ family
I6H45_06110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H45_06115	COG0217	transcriptional regulatory protein
I6H45_06120	COG1739	Uncharacterized protein family UPF0029
I6H45_06125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H45_06135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H45_06150	COG0745	RESPONSE REGULATOR receiver
I6H45_06175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H45_06180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H45_06195	COG0235	Class ii aldolase
I6H45_06205	COG3037	sugar-specific permease SgaT UlaA
I6H45_06210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H45_06220	COG1349	DNA-binding transcription factor activity
I6H45_06225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6H45_06240	COG1131	(ABC) transporter
I6H45_06245	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6H45_06250	COG1473	amidohydrolase
I6H45_06255	COG0596	Alpha beta hydrolase
I6H45_06260	COG1278	Cold shock
I6H45_06265	COG2226	methyltransferase
I6H45_06270	COG0525	valine-tRNA ligase activity
I6H45_06275	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H45_06280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H45_06280	COG0574	Belongs to the PEP-utilizing enzyme family
I6H45_06300	COG0745	RESPONSE REGULATOR receiver
I6H45_06305	COG2205	protein histidine kinase activity
I6H45_06310	COG1301	dicarboxylic acid transport
I6H45_06320	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H45_06325	COG0653	protein targeting
I6H45_06330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H45_06335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H45_06340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H45_06345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H45_06355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H45_06360	COG4946	Tricorn protease homolog
I6H45_06360	COG0823	Involved in the tonB-independent uptake of proteins
I6H45_06360	COG1506	peptidase
I6H45_06365	COG1295	ribonuclease BN
I6H45_06370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H45_06380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H45_06385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H45_06400	COG0305	Participates in initiation and elongation during chromosome replication
I6H45_06405	COG0359	binds to the 23S rRNA
I6H45_06420	COG0753	catalase activity
I6H45_06435	COG1024	Enoyl-CoA hydratase
I6H45_06445	COG1477	protein flavinylation
I6H45_06455	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H45_06460	COG0572	uridine kinase
I6H45_06465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H45_06475	COG0590	tRNA wobble adenosine to inosine editing
I6H45_06485	COG1686	Belongs to the peptidase S11 family
I6H45_06505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H45_06510	COG0758	DNA mediated transformation
I6H45_06515	COG0792	nuclease activity
I6H45_06520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H45_06525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H45_06535	COG5002	protein histidine kinase activity
I6H45_06540	COG1136	(ABC) transporter
I6H45_06550	COG0335	large ribosomal subunit rRNA binding
I6H45_06555	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H45_06560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H45_06570	COG0228	four-way junction DNA binding
I6H45_06575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H45_06580	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6H45_06595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H45_06600	COG1288	antiporter activity
I6H45_06605	COG0549	Belongs to the carbamate kinase family
I6H45_06610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H45_06615	COG2235	arginine
I6H45_06620	COG3708	Transcriptional regulator
I6H45_06620	COG2207	Transcriptional regulator
I6H45_06720	COG0251	oxidation-reduction process
I6H45_06735	COG0018	arginyl-trna synthetase
I6H45_06740	COG1193	negative regulation of DNA recombination
I6H45_06745	COG0826	peptidase U32
I6H45_06755	COG0072	phenylalanine-tRNA ligase activity
I6H45_06755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H45_06760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H45_06765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H45_06770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H45_06780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H45_06835	COG5012	cobalamin binding
I6H45_06845	COG0281	malic enzyme
I6H45_06850	COG0114	fumarate hydratase activity
I6H45_06855	COG0583	DNA-binding transcription factor activity
I6H45_06860	COG1794	racemase activity, acting on amino acids and derivatives
I6H45_06865	COG1301	dicarboxylic acid transport
I6H45_06870	COG1027	Aspartate ammonia-lyase
I6H45_06880	COG0584	glycerophosphoryl diester phosphodiesterase
I6H45_06885	COG1924	4 iron, 4 sulfur cluster binding
I6H45_06895	COG1242	4 iron, 4 sulfur cluster binding
I6H45_06900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H45_06905	COG0629	single-stranded DNA binding
I6H45_06910	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H45_06915	COG3191	aminopeptidase activity
I6H45_06930	COG0640	Transcriptional regulator
I6H45_06940	COG4824	toxin secretion phage lysis holin
I6H45_06970	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6H45_06995	COG0686	Belongs to the AlaDH PNT family
I6H45_07010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H45_07015	COG3842	ATPase activity
I6H45_07025	COG5426	von Willebrand factor, type A
I6H45_07030	COG0395	ABC-type sugar transport system, permease component
I6H45_07035	COG1175	transmembrane transport
I6H45_07040	COG1653	transport
I6H45_07050	COG1131	(ABC) transporter
I6H45_07055	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H45_07090	COG3340	Belongs to the peptidase S51 family
I6H45_07100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6H45_07175	COG0519	Catalyzes the synthesis of GMP from XMP
I6H45_07185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H45_07190	COG0751	glycine-tRNA ligase activity
I6H45_07195	COG0752	glycyl-tRNA synthetase alpha subunit
I6H45_07200	COG1381	Involved in DNA repair and RecF pathway recombination
I6H45_07205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H45_07210	COG0295	cytidine deaminase activity
I6H45_07215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H45_07225	COG1702	phosphate starvation-inducible protein PhoH
I6H45_07235	COG4864	UPF0365 protein
I6H45_07240	COG1030	water channel activity
I6H45_07245	COG1304	FMN binding
I6H45_07250	COG1316	TRANSCRIPTIONal
I6H45_07255	COG0561	phosphatase activity
I6H45_07270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H45_07285	COG0396	ATPase activity
I6H45_07290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H45_07295	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H45_07300	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H45_07305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H45_07310	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H45_07320	COG2239	Acts as a magnesium transporter
I6H45_07325	COG0793	Belongs to the peptidase S41A family
I6H45_07340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H45_07350	COG2217	Heavy metal translocating P-type atpase
I6H45_07405	COG0765	amino acid transport
I6H45_07425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H45_07440	COG2022	thiamine diphosphate biosynthetic process
I6H45_07445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H45_07455	COG0372	Belongs to the citrate synthase family
I6H45_07460	COG0473	3-isopropylmalate dehydrogenase activity
I6H45_07470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H45_07475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H45_07480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H45_07485	COG1979	alcohol dehydrogenase
I6H45_07500	COG3693	PFAM glycoside hydrolase, family 10
I6H45_07500	COG2382	esterase
I6H45_07525	COG2731	YhcH YjgK YiaL family protein
I6H45_07530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H45_07550	COG2226	methyltransferase
I6H45_07580	COG0733	neurotransmitter:sodium symporter activity
I6H45_07585	COG0402	S-adenosylhomocysteine deaminase activity
I6H45_07590	COG2252	PERMEase
I6H45_07600	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6H45_07620	COG1473	amidohydrolase
I6H45_07625	COG1546	Belongs to the CinA family
I6H45_07625	COG1058	Belongs to the CinA family
I6H45_07630	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H45_07630	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H45_07635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H45_07635	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H45_07640	COG1083	cytidylyl-transferase
I6H45_07645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H45_07650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H45_07665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6H45_07670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H45_07690	COG0402	S-adenosylhomocysteine deaminase activity
I6H45_07695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H45_07695	COG0493	'glutamate synthase
I6H45_07710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H45_07715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H45_07720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H45_07725	COG0709	Synthesizes selenophosphate from selenide and ATP
I6H45_07740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H45_07745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H45_07750	COG4149	molybdate abc transporter
I6H45_07755	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H45_07765	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H45_07770	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H45_07775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H45_07780	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6H45_07790	COG1802	Transcriptional regulator
I6H45_07795	COG0019	diaminopimelate decarboxylase activity
I6H45_07805	COG1177	transmembrane transport
I6H45_07810	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H45_07815	COG3842	ATPase activity
I6H45_07825	COG0789	Transcriptional regulator
I6H45_07850	COG1012	belongs to the aldehyde dehydrogenase family
I6H45_07850	COG1454	alcohol dehydrogenase
I6H45_07860	COG4869	propanediol catabolic process
I6H45_07890	COG1162	GTPase activity
I6H45_07900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H45_07905	COG1882	Formate acetyltransferase
I6H45_07915	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H45_07920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H45_07940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H45_07950	COG2078	PFAM AMMECR1 domain protein
I6H45_07950	COG3885	ferrous iron binding
I6H45_07955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H45_07970	COG1136	(ABC) transporter
I6H45_07975	COG2205	protein histidine kinase activity
I6H45_07985	COG0523	cobalamin synthesis protein
I6H45_08000	COG2081	HI0933 family
I6H45_08005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H45_08010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H45_08015	COG1263	PTS System
I6H45_08015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H45_08015	COG2190	(PTS) system
I6H45_08030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H45_08035	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6H45_08040	COG0084	hydrolase, TatD family'
I6H45_08045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H45_08045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H45_08050	COG3585	molybdate ion transport
I6H45_08055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H45_08080	COG0644	oxidoreductase
I6H45_08085	COG2226	methyltransferase
I6H45_08105	COG1556	Lactate utilization protein
I6H45_08110	COG0003	Pfam Anion-transporting ATPase
I6H45_08115	COG0003	Pfam Anion-transporting ATPase
I6H45_08120	COG1346	cytolysis
I6H45_08155	COG1045	serine acetyltransferase
I6H45_08170	COG0438	transferase activity, transferring glycosyl groups
I6H45_08180	COG0438	transferase activity, transferring glycosyl groups
I6H45_08195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H45_08205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6H45_08215	COG1316	TRANSCRIPTIONal
I6H45_08220	COG3579	cysteine-type endopeptidase activity
I6H45_08240	COG1214	PFAM Peptidase M22, glycoprotease
I6H45_08245	COG0802	atpase or kinase
I6H45_08275	COG1164	Oligoendopeptidase f
I6H45_08280	COG2309	aminopeptidase activity
I6H45_08360	COG0363	glucosamine-6-phosphate deaminase activity
I6H45_08370	COG3830	Belongs to the UPF0237 family
I6H45_08380	COG0166	Belongs to the GPI family
I6H45_08395	COG0366	Alpha amylase catalytic
I6H45_08400	COG0534	Mate efflux family protein
I6H45_08410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H45_08415	COG1802	Transcriptional regulator
I6H45_08450	COG2222	sugar isomerase
I6H45_08455	COG3684	Belongs to the aldolase LacD family
I6H45_08465	COG2971	BadF BadG BcrA BcrD
I6H45_08475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H45_08480	COG3715	PTS system
I6H45_08485	COG3716	PTS system mannose fructose sorbose family IID component
I6H45_08500	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H45_08500	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H45_08505	COG1121	(ABC) transporter
I6H45_08510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H45_08525	COG1979	alcohol dehydrogenase
I6H45_08535	COG1070	Carbohydrate kinase
I6H45_08540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H45_08550	COG1757	Na H antiporter
I6H45_08555	COG1349	DNA-binding transcription factor activity
I6H45_08560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6H45_08565	COG1285	pathogenesis
I6H45_08570	COG1115	amino acid carrier protein
I6H45_08575	COG0584	glycerophosphoryl diester phosphodiesterase
I6H45_08580	COG1253	flavin adenine dinucleotide binding
I6H45_08585	COG1394	ATPase activity, coupled to movement of substances
I6H45_08590	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6H45_08600	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6H45_08605	COG1527	subunit (C
I6H45_08610	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6H45_08615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H45_08620	COG1269	ATP hydrolysis coupled proton transport
I6H45_08630	COG1494	fructose-1,6-bisphosphatase
I6H45_08640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H45_08665	COG3976	FMN-binding domain protein
I6H45_08665	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6H45_08670	COG1053	succinate dehydrogenase
I6H45_08670	COG3976	FMN-binding domain protein
I6H45_08675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H45_08680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H45_08685	COG1132	(ABC) transporter
I6H45_08695	COG0616	signal peptide processing
I6H45_08700	COG1263	PTS System
I6H45_08700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H45_08705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H45_08715	COG1737	Transcriptional regulator
I6H45_08720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H45_08725	COG1846	Transcriptional regulator
I6H45_08735	COG3118	belongs to the thioredoxin family
I6H45_08750	COG0280	phosphate acetyltransferase
I6H45_08765	COG1475	DNA binding
I6H45_08770	COG1192	Involved in chromosome partitioning
I6H45_08775	COG1058	Belongs to the CinA family
I6H45_08775	COG1546	Belongs to the CinA family
I6H45_08785	COG0445	tRNA wobble uridine modification
I6H45_08790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H45_08795	COG1847	R3H domain protein
I6H45_08800	COG0706	membrane insertase activity
I6H45_08805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H45_08815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H45_08820	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H45_08825	COG0592	DNA-directed DNA polymerase activity
I6H45_08835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H45_08840	COG0187	DNA topoisomerase II activity
I6H45_08845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H45_08860	COG1191	sigma factor activity
I6H45_08865	COG4166	transmembrane transport
I6H45_08870	COG0601	transmembrane transport
I6H45_08875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H45_08880	COG0444	Belongs to the ABC transporter superfamily
I6H45_08885	COG4608	Belongs to the ABC transporter superfamily
I6H45_08885	COG4608	Belongs to the ABC transporter superfamily
I6H45_08905	COG2314	TM2 domain
I6H45_08920	COG0450	alkyl hydroperoxide reductase
I6H45_08925	COG1929	Belongs to the glycerate kinase type-1 family
I6H45_08930	COG0705	Rhomboid family
I6H45_08930	COG0457	Tetratricopeptide repeat
I6H45_08935	COG1164	Oligoendopeptidase f
I6H45_08955	COG0785	Cytochrome C biogenesis protein