locus-tag	class	description
ANT_00050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANT_00080	COG1725	Transcriptional regulator
ANT_00110	COG1131	(ABC) transporter
ANT_00120	COG1668	transmembrane transport
ANT_00140	COG1959	2 iron, 2 sulfur cluster binding
ANT_00170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ANT_00180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ANT_00250	COG1397	ADP-ribosylglycohydrolase
ANT_00270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ANT_00300	COG0297	glycogen (starch) synthase activity
ANT_00310	COG1007	ATP synthesis coupled electron transport
ANT_00420	COG1215	transferase activity, transferring glycosyl groups
ANT_00450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ANT_00480	COG1285	pathogenesis
ANT_00500	COG2814	Major facilitator Superfamily
ANT_00510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ANT_00530	COG0497	DNA recombination
ANT_00600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ANT_00640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ANT_00670	COG1994	Peptidase M50
ANT_00680	COG4481	Protein conserved in bacteria
ANT_00690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANT_00720	COG0733	neurotransmitter:sodium symporter activity
ANT_00780	COG3250	beta-galactosidase activity
ANT_00790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANT_00800	COG1215	transferase activity, transferring glycosyl groups
ANT_00810	COG3706	GGDEF domain
ANT_00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ANT_00840	COG1122	ATPase activity
ANT_00850	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ANT_00880	COG0488	(ABC) transporter
ANT_00910	COG0406	alpha-ribazole phosphatase activity
ANT_00920	COG5001	Diguanylate cyclase
ANT_00920	COG3300	MHYT domain
ANT_00960	COG1307	EDD domain protein, DegV family
ANT_00970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ANT_01000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ANT_01070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANT_01090	COG0180	Tryptophanyl-tRNA synthetase
ANT_01100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANT_01120	COG1136	(ABC) transporter
ANT_01120	COG0577	efflux transmembrane transporter activity
ANT_01130	COG1136	(ABC) transporter
ANT_01140	COG0577	efflux transmembrane transporter activity
ANT_01140	COG1136	(ABC) transporter
ANT_01150	COG1309	transcriptional regulator
ANT_01170	COG3706	GGDEF domain
ANT_01230	COG2186	Transcriptional regulator
ANT_01240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANT_01250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ANT_01260	COG0549	Belongs to the carbamate kinase family
ANT_01340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ANT_01350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ANT_01360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ANT_01370	COG0747	negative chemotaxis
ANT_01380	COG0601	transmembrane transport
ANT_01390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANT_01400	COG0444	Belongs to the ABC transporter superfamily
ANT_01410	COG4608	Belongs to the ABC transporter superfamily
ANT_01420	COG2204	response regulator
ANT_01430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ANT_01440	COG1028	Short-chain dehydrogenase reductase Sdr
ANT_01450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ANT_01490	COG1846	Transcriptional regulator
ANT_01500	COG1132	(ABC) transporter
ANT_01510	COG1132	(ABC) transporter
ANT_01520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ANT_01580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANT_01590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANT_01600	COG0861	Integral membrane protein TerC family
ANT_01620	COG1528	Iron-storage protein
ANT_01640	COG2226	methyltransferase
ANT_01650	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ANT_01660	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ANT_01680	COG3854	ATPases associated with a variety of cellular activities
ANT_01690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ANT_01730	COG0438	transferase activity, transferring glycosyl groups
ANT_01750	COG5002	protein histidine kinase activity
ANT_01760	COG0745	RESPONSE REGULATOR receiver
ANT_01780	COG1653	transport
ANT_01800	COG0395	ABC-type sugar transport system, permease component
ANT_01840	COG0205	6-phosphofructokinase activity
ANT_01870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANT_01880	COG0287	Prephenate dehydrogenase
ANT_01890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ANT_01900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ANT_01910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ANT_01950	COG0154	amidase activity
ANT_02010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ANT_02020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ANT_02040	COG1012	belongs to the aldehyde dehydrogenase family
ANT_02070	COG2770	Histidine kinase
ANT_02070	COG3437	response regulator, receiver
ANT_02230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ANT_02240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ANT_02250	COG3170	Tfp pilus assembly protein FimV
ANT_02250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ANT_02270	COG0195	Participates in both transcription termination and antitermination
ANT_02350	COG1131	(ABC) transporter
ANT_02380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ANT_02390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ANT_02400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ANT_02470	COG1744	ABC transporter substrate-binding protein PnrA-like
ANT_02480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ANT_02510	COG1120	ATPase activity
ANT_02520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ANT_02530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ANT_02560	COG1595	DNA-templated transcription, initiation
ANT_02590	COG1846	Transcriptional regulator
ANT_02600	COG1132	(ABC) transporter
ANT_02610	COG1132	(ABC) transporter
ANT_02630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANT_02640	COG0573	inorganic phosphate transmembrane transporter activity
ANT_02650	COG0581	inorganic phosphate transmembrane transporter activity
ANT_02660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANT_02680	COG0475	glutathione-regulated potassium exporter activity
ANT_02690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANT_02690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANT_02700	COG0346	lactoylglutathione lyase activity
ANT_02710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ANT_02720	COG3706	GGDEF domain
ANT_02740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ANT_02780	COG0424	maF-like protein
ANT_02790	COG0768	penicillin binding
ANT_02800	COG1162	GTPase activity
ANT_02820	COG3300	MHYT domain
ANT_02820	COG5001	Diguanylate cyclase
ANT_02850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ANT_02860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ANT_02880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANT_02900	COG0196	riboflavin kinase activity
ANT_02930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ANT_02950	COG0402	S-adenosylhomocysteine deaminase activity
ANT_02990	COG4603	Belongs to the binding-protein-dependent transport system permease family
ANT_03010	COG3118	belongs to the thioredoxin family
ANT_03030	COG0167	dihydroorotate dehydrogenase activity
ANT_03090	COG1575	Belongs to the MenA family. Type 1 subfamily
ANT_03130	COG0436	Aminotransferase
ANT_03170	COG0154	amidase activity
ANT_03180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANT_03250	COG0129	dihydroxy-acid dehydratase activity
ANT_03260	COG0028	Belongs to the TPP enzyme family
ANT_03270	COG0440	acetolactate synthase activity
ANT_03280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ANT_03310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANT_03320	COG0066	3-isopropylmalate dehydratase activity
ANT_03330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANT_03340	COG0473	3-isopropylmalate dehydrogenase activity
ANT_03360	COG0077	Prephenate dehydratase
ANT_03360	COG1605	Chorismate mutase
ANT_03370	COG1993	acr, cog1993
ANT_03380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ANT_03450	COG2770	Histidine kinase
ANT_03450	COG3437	response regulator, receiver
ANT_03490	COG0575	Belongs to the CDS family
ANT_03510	COG0233	cytoplasmic translational termination
ANT_03520	COG0640	Transcriptional regulator
ANT_03530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ANT_03560	COG1160	GTP binding
ANT_03590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ANT_03620	COG0784	Response regulator, receiver
ANT_03620	COG3437	response regulator, receiver
ANT_03640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ANT_03710	COG2020	methyltransferase activity
ANT_03730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ANT_03750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ANT_03840	COG0359	binds to the 23S rRNA
ANT_03860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANT_03930	COG1045	serine acetyltransferase
ANT_03940	COG0538	isocitrate dehydrogenase activity
ANT_03950	COG0393	Putative heavy-metal-binding
ANT_03980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANT_03990	COG3684	Belongs to the aldolase LacD family
ANT_04010	COG1486	melibiose metabolic process
ANT_04020	COG0395	ABC-type sugar transport system, permease component
ANT_04030	COG1175	transmembrane transport
ANT_04040	COG1653	transport
ANT_04050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ANT_04080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANT_04100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANT_04120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ANT_04130	COG4585	Histidine kinase
ANT_04140	COG0542	response to heat
ANT_04160	COG1950	PFAM Membrane protein of
ANT_04190	COG0765	amino acid transport
ANT_04210	COG0506	proline dehydrogenase activity
ANT_04230	COG0303	'Molybdopterin
ANT_04240	COG0726	polysaccharide deacetylase
ANT_04260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANT_04270	COG1959	2 iron, 2 sulfur cluster binding
ANT_04290	COG2010	Cytochrome c
ANT_04310	COG2197	response regulator
ANT_04320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANT_04330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANT_04340	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
ANT_04370	COG0187	DNA topoisomerase II activity
ANT_04430	COG3870	Protein conserved in bacteria
ANT_04530	COG0542	response to heat
ANT_04540	COG0335	large ribosomal subunit rRNA binding
ANT_04550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ANT_04580	COG0395	ABC-type sugar transport system, permease component
ANT_04660	COG0463	Glycosyl transferase, family 2
ANT_04670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANT_04770	COG2909	trisaccharide binding
ANT_04780	COG0494	nUDIX hydrolase
ANT_04800	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ANT_04810	COG0372	Belongs to the citrate synthase family
ANT_04840	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ANT_04860	COG1803	Methylglyoxal synthase
ANT_04900	COG1937	Protein conserved in bacteria
ANT_04920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANT_04930	COG0083	homoserine kinase activity
ANT_04940	COG1575	Belongs to the MenA family. Type 1 subfamily
ANT_04950	COG0183	Belongs to the thiolase family
ANT_05010	COG1234	tRNA 3'-trailer cleavage
ANT_05030	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ANT_05040	COG0058	SHG alpha-glucan phosphorylase activity
ANT_05070	COG1846	Transcriptional regulator
ANT_05080	COG2353	YceI-like domain
ANT_05100	COG2326	polyphosphate kinase activity
ANT_05110	COG1234	tRNA 3'-trailer cleavage
ANT_05170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANT_05220	COG0405	Gamma-glutamyltransferase
ANT_05230	COG0322	excinuclease ABC activity
ANT_05240	COG0109	protoheme IX farnesyltransferase activity
ANT_05240	COG1612	heme a metabolic process
ANT_05300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANT_05350	COG0275	rRNA processing
ANT_05370	COG2723	6-phospho-beta-galactosidase activity
ANT_05380	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ANT_05410	COG1609	Transcriptional regulator
ANT_05420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANT_05430	COG1869	D-ribose catabolic process
ANT_05440	COG1172	Belongs to the binding-protein-dependent transport system permease family
ANT_05450	COG1879	ABC-type sugar transport system periplasmic component
ANT_05460	COG1129	ABC transporter
ANT_05470	COG1172	Belongs to the binding-protein-dependent transport system permease family
ANT_05480	COG1131	(ABC) transporter
ANT_05580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANT_05660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ANT_05670	COG1304	FMN binding
ANT_05730	COG2233	PERMEase
ANT_05800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ANT_05820	COG4770	biotin carboxylase activity
ANT_05830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ANT_05870	COG0745	RESPONSE REGULATOR receiver
ANT_05890	COG0159	tryptophan synthase activity
ANT_05900	COG0133	tryptophan synthase activity
ANT_05910	COG0135	phosphoribosylanthranilate isomerase activity
ANT_05920	COG0134	indole-3-glycerol-phosphate synthase activity
ANT_05930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANT_05940	COG0512	Glutamine amidotransferase of anthranilate synthase
ANT_05950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ANT_05970	COG1320	monovalent cation:proton antiporter activity
ANT_05980	COG2212	antiporter activity
ANT_06020	COG2111	Na H antiporter
ANT_06060	COG1970	mechanosensitive ion channel activity
ANT_06070	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANT_06170	COG0463	Glycosyl transferase, family 2
ANT_06180	COG1316	TRANSCRIPTIONal
ANT_06200	COG2340	Cysteine-rich secretory protein family
ANT_06210	COG2720	vancomycin resistance protein
ANT_06220	COG0629	single-stranded DNA binding
ANT_06260	COG1316	TRANSCRIPTIONal
ANT_06290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANT_06340	COG1086	Polysaccharide biosynthesis protein
ANT_06360	COG2089	acid synthase
ANT_06370	COG0438	transferase activity, transferring glycosyl groups
ANT_06380	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ANT_06420	COG0481	GTPase activity
ANT_06460	COG1083	cytidylyl-transferase
ANT_06470	COG2089	acid synthase
ANT_06480	COG3562	capsule polysaccharide
ANT_06490	COG1083	cytidylyl-transferase
ANT_06500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANT_06520	COG1028	Short-chain dehydrogenase reductase Sdr
ANT_06540	COG1215	transferase activity, transferring glycosyl groups
ANT_06590	COG0745	RESPONSE REGULATOR receiver
ANT_06600	COG5002	protein histidine kinase activity
ANT_06610	COG0745	RESPONSE REGULATOR receiver
ANT_06630	COG4608	Belongs to the ABC transporter superfamily
ANT_06640	COG0444	Belongs to the ABC transporter superfamily
ANT_06650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANT_06660	COG0601	transmembrane transport
ANT_06670	COG4166	transmembrane transport
ANT_06690	COG1564	THIamine pyrophosphokinase
ANT_06710	COG1178	ABC-type Fe3 transport system permease component
ANT_06810	COG0745	RESPONSE REGULATOR receiver
ANT_06820	COG1846	Transcriptional regulator
ANT_06840	COG0305	Participates in initiation and elongation during chromosome replication
ANT_06860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANT_06870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ANT_06920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ANT_06960	COG4555	ABC transporter
ANT_06980	COG0673	inositol 2-dehydrogenase activity
ANT_06990	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ANT_07000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ANT_07010	COG0698	ribose 5-phosphate isomerase
ANT_07040	COG1363	Peptidase, m42
ANT_07080	COG0583	DNA-binding transcription factor activity
ANT_07100	COG1129	ABC transporter
ANT_07110	COG1172	Belongs to the binding-protein-dependent transport system permease family
ANT_07150	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ANT_07160	COG3192	ethanolamine utilization protein
ANT_07170	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANT_07190	COG4303	Ethanolamine ammonia lyase large subunit
ANT_07200	COG4302	ethanolamine ammonia-lyase activity
ANT_07210	COG4816	utilization protein
ANT_07220	COG1454	alcohol dehydrogenase
ANT_07220	COG1012	belongs to the aldehyde dehydrogenase family
ANT_07230	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANT_07260	COG4820	ethanolamine utilization protein (EutJ)
ANT_07320	COG1104	cysteine desulfurase activity
ANT_07340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANT_07350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ANT_07350	COG0392	lysyltransferase activity
ANT_07380	COG1914	H( )-stimulated, divalent metal cation uptake system
ANT_07430	COG0739	heme binding
ANT_07440	COG1355	regulation of microtubule-based process
ANT_07450	COG1253	flavin adenine dinucleotide binding
ANT_07480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ANT_07490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ANT_07520	COG0640	Transcriptional regulator
ANT_07550	COG1233	COG1233 Phytoene dehydrogenase and related
ANT_07630	COG0656	L-ascorbic acid biosynthetic process
ANT_07650	COG0577	efflux transmembrane transporter activity
ANT_07650	COG1136	(ABC) transporter
ANT_07660	COG1136	(ABC) transporter
ANT_07670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANT_07680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ANT_07690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ANT_07720	COG1136	(ABC) transporter
ANT_07740	COG0577	efflux transmembrane transporter activity
ANT_07760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANT_07760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANT_07770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANT_07860	COG1316	TRANSCRIPTIONal
ANT_07880	COG0697	spore germination
ANT_07890	COG5002	protein histidine kinase activity
ANT_07900	COG0745	RESPONSE REGULATOR receiver
ANT_07920	COG1136	(ABC) transporter
ANT_07930	COG0577	efflux transmembrane transporter activity
ANT_07930	COG1136	(ABC) transporter
ANT_08060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ANT_08070	COG0395	ABC-type sugar transport system, permease component
ANT_08080	COG1175	transmembrane transport
ANT_08120	COG1940	carbohydrate kinase activity
ANT_08150	COG1131	(ABC) transporter
ANT_08190	COG1278	Cold shock
ANT_08200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANT_08210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANT_08220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANT_08230	COG0066	3-isopropylmalate dehydratase activity
ANT_08240	COG0473	3-isopropylmalate dehydrogenase activity
ANT_08250	COG0189	ligase activity
ANT_08290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANT_08300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANT_08310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANT_08320	COG0649	NAD binding
ANT_08350	COG1034	ATP synthesis coupled electron transport
ANT_08360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ANT_08370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANT_08380	COG0839	Belongs to the complex I subunit 6 family
ANT_08390	COG0713	ATP synthesis coupled electron transport
ANT_08420	COG1007	ATP synthesis coupled electron transport
ANT_08450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANT_08470	COG0442	prolyl-tRNA aminoacylation
ANT_08510	COG2094	Belongs to the DNA glycosylase MPG family
ANT_08520	COG0516	GMP reductase activity
ANT_08520	COG0517	IMP dehydrogenase activity
ANT_08530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANT_08540	COG1592	Rubrerythrin
ANT_08560	COG0798	PFAM Bile acid sodium symporter
ANT_08580	COG3706	GGDEF domain
ANT_08580	COG0745	RESPONSE REGULATOR receiver
ANT_08610	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ANT_08620	COG1381	Involved in DNA repair and RecF pathway recombination
ANT_08630	COG0295	cytidine deaminase activity
ANT_08640	COG4535	Mg2 and Co2 transporter CorC
ANT_08650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ANT_08660	COG0799	negative regulation of ribosome biogenesis
ANT_08670	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ANT_08710	COG0358	DNA primase activity
ANT_08720	COG3409	Peptidoglycan-binding domain 1 protein
ANT_08720	COG5632	N-Acetylmuramoyl-L-alanine amidase
ANT_08730	COG0751	glycine-tRNA ligase activity
ANT_08730	COG0752	glycyl-tRNA synthetase alpha subunit
ANT_08750	COG4585	Histidine kinase
ANT_08770	COG1136	(ABC) transporter
ANT_08770	COG0577	efflux transmembrane transporter activity
ANT_08780	COG1136	(ABC) transporter
ANT_08790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANT_08810	COG1486	melibiose metabolic process
ANT_08820	COG1486	melibiose metabolic process
ANT_08840	COG4608	Belongs to the ABC transporter superfamily
ANT_08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANT_08860	COG0601	transmembrane transport
ANT_08870	COG0747	negative chemotaxis
ANT_08880	COG0444	Belongs to the ABC transporter superfamily
ANT_08900	COG2205	protein histidine kinase activity
ANT_08900	COG2202	Pas domain
ANT_08920	COG4974	Belongs to the 'phage' integrase family
ANT_08930	COG1316	TRANSCRIPTIONal
ANT_08980	COG1175	transmembrane transport
ANT_08990	COG0395	ABC-type sugar transport system, permease component
ANT_09030	COG3848	Pyruvate phosphate dikinase
ANT_09030	COG0574	Belongs to the PEP-utilizing enzyme family
ANT_09040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANT_09090	COG3706	GGDEF domain
ANT_09090	COG0745	RESPONSE REGULATOR receiver
ANT_09140	COG3706	GGDEF domain
ANT_09170	COG2199	diguanylate cyclase activity
ANT_09170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ANT_09240	COG0534	Mate efflux family protein
ANT_09250	COG2205	protein histidine kinase activity
ANT_09260	COG0745	RESPONSE REGULATOR receiver
ANT_09270	COG1070	Carbohydrate kinase
ANT_09280	COG4221	oxidoreductase activity
ANT_09310	COG0745	RESPONSE REGULATOR receiver
ANT_09320	COG2205	protein histidine kinase activity
ANT_09360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ANT_09370	COG0739	heme binding
ANT_09390	COG1490	D-aminoacyl-tRNA deacylase activity
ANT_09440	COG0826	peptidase U32
ANT_09470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ANT_09480	COG0237	dephospho-CoA kinase activity
ANT_09550	COG0714	Associated with various cellular activities
ANT_09590	COG0725	ABC transporter, periplasmic molybdate-binding protein
ANT_09600	COG1668	transmembrane transport
ANT_09620	COG4152	abc transporter atp-binding protein
ANT_09630	COG2890	protein-(glutamine-N5) methyltransferase activity
ANT_09640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ANT_09660	COG3259	Nickel-dependent hydrogenase
ANT_09670	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
ANT_09700	COG1792	Involved in formation and maintenance of cell shape
ANT_09740	COG2894	cell division
ANT_09750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ANT_09760	COG0772	Belongs to the SEDS family
ANT_09770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANT_09790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ANT_09800	COG0564	pseudouridine synthase activity
ANT_09820	COG3706	GGDEF domain
ANT_09840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ANT_09890	COG1674	ftsk spoiiie
ANT_09900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANT_09910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ANT_09920	COG4555	ABC transporter
ANT_09950	COG1090	epimerase
ANT_09960	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ANT_09970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ANT_09990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ANT_10000	COG0049	tRNA binding
ANT_10010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANT_10020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANT_10030	COG0051	transcription antitermination factor activity, RNA binding
ANT_10040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ANT_10050	COG0088	Forms part of the polypeptide exit tunnel
ANT_10060	COG0089	rRNA binding
ANT_10070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ANT_10090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ANT_10100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ANT_10110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ANT_10120	COG0255	Belongs to the universal ribosomal protein uL29 family
ANT_10130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ANT_10140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ANT_10150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ANT_10160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ANT_10170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ANT_10180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ANT_10190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ANT_10200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ANT_10210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ANT_10220	COG1841	ribosomal large subunit assembly
ANT_10230	COG0200	Binds to the 23S rRNA
ANT_10240	COG0201	protein transport
ANT_10250	COG0563	adenylate kinase activity
ANT_10270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ANT_10280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ANT_10290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ANT_10300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ANT_10310	COG0202	RNA polymerase activity
ANT_10320	COG0203	ribosomal protein L17
ANT_10330	COG0101	tRNA pseudouridine synthase activity
ANT_10340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ANT_10350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ANT_10380	COG3956	TIGRFAM MazG family protein
ANT_10410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANT_10450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANT_10480	COG1007	ATP synthesis coupled electron transport
ANT_10500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANT_10530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANT_10540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANT_10550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ANT_10560	COG2983	Belongs to the UPF0260 family
ANT_10570	COG1185	polyribonucleotide nucleotidyltransferase activity
ANT_10580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ANT_10590	COG1056	cytidyltransferase-related domain
ANT_10590	COG1051	belongs to the nudix hydrolase family
ANT_10600	COG0442	prolyl-tRNA aminoacylation
ANT_10620	COG0617	tRNA 3'-terminal CCA addition
ANT_10660	COG0495	leucyl-tRNA aminoacylation
ANT_10680	COG1074	ATP-dependent DNA helicase activity
ANT_10710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANT_10720	COG4988	ABC transporter
ANT_10730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ANT_10750	COG0697	spore germination
ANT_10770	COG0527	aspartate kinase activity
ANT_10770	COG0460	homoserine dehydrogenase
ANT_10780	COG1122	ATPase activity
ANT_10790	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ANT_10810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ANT_10820	COG5002	protein histidine kinase activity
ANT_10830	COG0745	RESPONSE REGULATOR receiver
ANT_10850	COG5002	protein histidine kinase activity
ANT_10860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ANT_10870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ANT_10900	COG2949	membrane
ANT_10910	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ANT_10920	COG0095	Lipoate-protein ligase
ANT_10930	COG0747	negative chemotaxis
ANT_10940	COG0601	transmembrane transport
ANT_10950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANT_10960	COG0444	Belongs to the ABC transporter superfamily
ANT_10970	COG4608	Belongs to the ABC transporter superfamily
ANT_10990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANT_11000	COG1672	PFAM Archaeal ATPase
ANT_11000	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ANT_11050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ANT_11080	COG1486	melibiose metabolic process
ANT_11100	COG0673	inositol 2-dehydrogenase activity
ANT_11130	COG0673	inositol 2-dehydrogenase activity
ANT_11150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ANT_11180	COG1051	belongs to the nudix hydrolase family
ANT_11190	COG0717	Belongs to the dCTP deaminase family
ANT_11220	COG2135	peptidase activity
ANT_11250	COG0784	Response regulator, receiver
ANT_11250	COG2205	protein histidine kinase activity
ANT_11250	COG5002	protein histidine kinase activity
ANT_11270	COG1811	Na channel or pump
ANT_11280	COG2096	Adenosyltransferase
ANT_11300	COG4166	transmembrane transport
ANT_11330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ANT_11390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ANT_11410	COG1331	Highly conserved protein containing a thioredoxin domain
ANT_11440	COG0395	ABC-type sugar transport system, permease component
ANT_11450	COG1175	transmembrane transport
ANT_11600	COG0191	fructose-bisphosphate aldolase activity
ANT_11620	COG0742	ribosomal rna small subunit methyltransferase
ANT_11670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANT_11700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ANT_11710	COG1187	pseudouridine synthase activity
ANT_11740	COG4191	Histidine kinase
ANT_11750	COG0745	RESPONSE REGULATOR receiver
ANT_11770	COG0745	RESPONSE REGULATOR receiver
ANT_11770	COG3706	GGDEF domain
ANT_11790	COG1192	Involved in chromosome partitioning
ANT_11840	COG0745	RESPONSE REGULATOR receiver
ANT_11850	COG2205	protein histidine kinase activity
ANT_11850	COG0784	Response regulator, receiver
ANT_11930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ANT_11940	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ANT_11950	COG0646	methionine synthase
ANT_11950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ANT_11960	COG0646	methionine synthase
ANT_11960	COG1410	methionine synthase
ANT_11990	COG1921	L-seryl-tRNASec selenium transferase activity
ANT_12000	COG0006	proline dipeptidase activity
ANT_12010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ANT_12060	COG1765	OsmC-like protein
ANT_12130	COG1260	myo-inositol-1-phosphate synthase
ANT_12140	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ANT_12160	COG0765	amino acid transport
ANT_12170	COG1126	abc transporter atp-binding protein
ANT_12190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANT_12200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANT_12220	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ANT_12230	COG1518	maintenance of DNA repeat elements
ANT_12370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANT_12380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ANT_12390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ANT_12400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ANT_12410	COG0189	ligase activity
ANT_12430	COG0165	Argininosuccinate lyase
ANT_12440	COG0137	argininosuccinate synthase activity
ANT_12480	COG4585	Histidine kinase
ANT_12480	COG2203	Gaf domain
ANT_12490	COG2197	response regulator
ANT_12500	COG0517	IMP dehydrogenase activity
ANT_12500	COG0516	GMP reductase activity
ANT_12510	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ANT_12530	COG3383	formate dehydrogenase (NAD+) activity
ANT_12540	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
ANT_12550	COG3259	Nickel-dependent hydrogenase
ANT_12590	COG2217	Heavy metal translocating P-type atpase
ANT_12610	COG1937	Protein conserved in bacteria
ANT_12620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANT_12630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ANT_12670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANT_12680	COG0735	belongs to the Fur family
ANT_12690	COG0310	cobalt ion transport
ANT_12700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ANT_12710	COG1122	ATPase activity
ANT_12730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ANT_12740	COG2270	Major facilitator Superfamily
ANT_12780	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ANT_12840	COG1674	ftsk spoiiie
ANT_12890	COG0559	Belongs to the binding-protein-dependent transport system permease family
ANT_12900	COG0683	leucine binding
ANT_12910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ANT_12920	COG0745	RESPONSE REGULATOR receiver
ANT_12940	COG0793	Belongs to the peptidase S41A family
ANT_12970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ANT_13000	COG1418	mRNA catabolic process
ANT_13040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ANT_13070	COG1968	undecaprenyl-diphosphatase activity
ANT_13110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ANT_13120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ANT_13120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ANT_13130	COG0463	Glycosyl transferase, family 2
ANT_13180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ANT_13190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ANT_13200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ANT_13220	COG0018	arginyl-trna synthetase
ANT_13230	COG0268	Binds directly to 16S ribosomal RNA
ANT_13240	COG0126	phosphoglycerate kinase activity
ANT_13260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ANT_13270	COG1940	carbohydrate kinase activity
ANT_13300	COG2205	protein histidine kinase activity
ANT_13320	COG0745	RESPONSE REGULATOR receiver
ANT_13330	COG0515	serine threonine protein kinase
ANT_13330	COG2815	serine threonine protein kinase
ANT_13350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ANT_13360	COG0584	glycerophosphoryl diester phosphodiesterase
ANT_13370	COG1222	aaa ATPase
ANT_13380	COG1085	galactose-1-phosphate uridylyltransferase
ANT_13390	COG1428	Deoxynucleoside kinase
ANT_13430	COG0415	Belongs to the DNA photolyase family
ANT_13450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANT_13510	COG0789	Transcriptional regulator
ANT_13580	COG0745	RESPONSE REGULATOR receiver
ANT_13600	COG2198	Histidine kinase
ANT_13600	COG2205	protein histidine kinase activity
ANT_13600	COG0784	Response regulator, receiver
ANT_13670	COG1069	ribulokinase activity
ANT_13700	COG1609	Transcriptional regulator
ANT_13730	COG0217	transcriptional regulatory protein
ANT_13740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ANT_13760	COG0632	four-way junction helicase activity
ANT_13770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ANT_13780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ANT_13790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ANT_13800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ANT_13820	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ANT_13830	COG2738	Putative neutral zinc metallopeptidase
ANT_13890	COG0745	RESPONSE REGULATOR receiver
ANT_13900	COG5002	protein histidine kinase activity
ANT_13910	COG5002	protein histidine kinase activity
ANT_13940	COG5002	protein histidine kinase activity
ANT_13960	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ANT_13970	COG1475	DNA binding
ANT_13980	COG1192	Involved in chromosome partitioning
ANT_14010	COG2003	Belongs to the UPF0758 family
ANT_14030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANT_14070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ANT_14080	COG0542	response to heat
ANT_14090	COG1716	ATPase activity
ANT_14140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ANT_14150	COG2222	sugar isomerase
ANT_14160	COG1435	thymidine kinase activity
ANT_14180	COG0617	tRNA 3'-terminal CCA addition
ANT_14190	COG2267	carboxylic ester hydrolase activity
ANT_14220	COG0745	RESPONSE REGULATOR receiver
ANT_14230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANT_14230	COG0574	Belongs to the PEP-utilizing enzyme family
ANT_14260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ANT_14270	COG0022	dehydrogenase e1 component
ANT_14280	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANT_14290	COG0741	lytic transglycosylase activity
ANT_14330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ANT_14340	COG1480	7TM receptor with intracellular HD hydrolase
ANT_14370	COG3872	metal-dependent enzyme
ANT_14380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANT_14390	COG0402	S-adenosylhomocysteine deaminase activity
ANT_14410	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ANT_14410	COG0778	Nitroreductase
ANT_14450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ANT_14470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ANT_14470	COG2080	2 iron, 2 sulfur cluster binding
ANT_14480	COG3608	succinylglutamate desuccinylase aspartoacylase
ANT_14480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ANT_14510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ANT_14520	COG3608	succinylglutamate desuccinylase aspartoacylase
ANT_14520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ANT_14540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ANT_14570	COG1205	dead DEAH box helicase
ANT_14570	COG1111	helicase
ANT_14590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ANT_14610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANT_14630	COG3875	lactate racemase activity
ANT_14670	COG2414	aldehyde ferredoxin oxidoreductase
ANT_14680	COG1063	alcohol dehydrogenase
ANT_14700	COG0142	geranyltranstransferase activity
ANT_14710	COG0084	hydrolase, TatD family'
ANT_14720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANT_14730	COG1104	cysteine desulfurase activity
ANT_14740	COG0482	sulfurtransferase activity
ANT_14790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ANT_14800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ANT_14810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ANT_14820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ANT_14830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANT_14850	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ANT_14860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ANT_14870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ANT_14890	COG2267	carboxylic ester hydrolase activity
ANT_14910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ANT_14950	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ANT_14970	COG0363	glucosamine-6-phosphate deaminase activity
ANT_15000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ANT_15020	COG2814	Major facilitator Superfamily
ANT_15040	COG3608	succinylglutamate desuccinylase aspartoacylase
ANT_15040	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ANT_15050	COG0805	protein transport
ANT_15100	COG3118	belongs to the thioredoxin family
ANT_15110	COG0745	RESPONSE REGULATOR receiver
ANT_15140	COG0484	heat shock protein binding
ANT_15160	COG0515	serine threonine protein kinase
ANT_15160	COG2815	serine threonine protein kinase
ANT_15170	COG0114	fumarate hydratase activity
ANT_15210	COG0515	serine threonine protein kinase
ANT_15210	COG2815	serine threonine protein kinase
ANT_15220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ANT_15230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ANT_15250	COG1461	Dihydroxyacetone kinase
ANT_15270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ANT_15280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ANT_15300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANT_15310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANT_15350	COG0745	RESPONSE REGULATOR receiver
ANT_15360	COG5002	protein histidine kinase activity
ANT_15370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ANT_15410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ANT_15410	COG1199	ATP-dependent helicase activity
ANT_15430	COG1396	sequence-specific DNA binding
ANT_15440	COG0138	bifunctional purine biosynthesis protein purh
ANT_15460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ANT_15470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANT_15510	COG2197	response regulator
ANT_15520	COG4585	Histidine kinase
ANT_15540	COG1612	heme a metabolic process
ANT_15540	COG0109	protoheme IX farnesyltransferase activity
ANT_15550	COG1032	radical SAM domain protein
ANT_15570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ANT_15600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ANT_15600	COG0045	succinate-CoA ligase (ADP-forming) activity
ANT_15600	COG1042	CoA-binding domain protein
ANT_15620	COG1122	ATPase activity
ANT_15640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ANT_15670	COG5002	protein histidine kinase activity
ANT_15680	COG4974	Belongs to the 'phage' integrase family
ANT_15720	COG0535	radical SAM domain protein
ANT_15730	COG0535	radical SAM domain protein
ANT_15740	COG2226	methyltransferase
ANT_15750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANT_15770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ANT_15820	COG0110	maltose O-acetyltransferase activity
ANT_15840	COG0328	RNA-DNA hybrid ribonuclease activity
ANT_15890	COG0438	transferase activity, transferring glycosyl groups
ANT_15910	COG0481	GTPase activity
ANT_15920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ANT_15930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANT_15960	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ANT_15990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANT_16010	COG0758	DNA mediated transformation
ANT_16010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANT_16020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ANT_16030	COG1837	Belongs to the UPF0109 family
ANT_16040	COG0228	four-way junction DNA binding
ANT_16050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ANT_16090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANT_16110	COG2137	regulation of response to DNA damage stimulus
ANT_16170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ANT_16190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ANT_16200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANT_16210	COG0039	L-malate dehydrogenase activity
ANT_16230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANT_16260	COG0067	glutamate synthase
ANT_16260	COG0069	glutamate synthase activity
ANT_16260	COG0070	glutamate synthase
ANT_16270	COG2197	response regulator
ANT_16280	COG3850	Histidine kinase
ANT_16280	COG0642	Histidine kinase
ANT_16290	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ANT_16300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ANT_16320	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ANT_16340	COG1278	Cold shock
ANT_16350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ANT_16360	COG1760	l-serine dehydratase
ANT_16430	COG0745	RESPONSE REGULATOR receiver
ANT_16460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANT_16480	COG0443	Heat shock 70 kDa protein
ANT_16510	COG1509	lysine 2,3-aminomutase activity
ANT_16550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANT_16580	COG1042	CoA-binding domain protein
ANT_16580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ANT_16580	COG0045	succinate-CoA ligase (ADP-forming) activity
ANT_16610	COG0740	serine-type endopeptidase activity
ANT_16620	COG0647	UMP catabolic process
ANT_16630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ANT_16640	COG0552	protein localization to endoplasmic reticulum
ANT_16650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ANT_16660	COG0446	pyridine nucleotide-disulphide oxidoreductase
ANT_16680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ANT_16690	COG0303	'Molybdopterin
ANT_16720	COG4106	trans-aconitate 2-methyltransferase activity
ANT_16760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANT_16770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANT_16790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANT_16800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANT_16820	COG1408	metallophosphoesterase
ANT_16830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ANT_16840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ANT_16890	COG2204	response regulator
ANT_16900	COG3852	Histidine kinase
ANT_16920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ANT_16930	COG2234	aminopeptidase activity
ANT_16940	COG5002	protein histidine kinase activity
ANT_16950	COG0436	Aminotransferase
ANT_16960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ANT_16980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ANT_16990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ANT_17010	COG0179	Fumarylacetoacetate (FAA) hydrolase
ANT_17050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANT_17060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANT_17070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANT_17090	COG0489	protein tyrosine kinase activity
ANT_17110	COG4214	carbohydrate transport
ANT_17130	COG4213	ABC transporter substrate-binding protein
ANT_17140	COG1129	ABC transporter
ANT_17160	COG1172	Belongs to the binding-protein-dependent transport system permease family
ANT_17180	COG2197	response regulator
ANT_17210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANT_17220	COG2414	aldehyde ferredoxin oxidoreductase
ANT_17240	COG1705	Flagellar rod assembly protein muramidase FlgJ
ANT_17240	COG1388	LysM domain
ANT_17250	COG0492	ferredoxin-NADP+ reductase activity
ANT_17280	COG1028	Short-chain dehydrogenase reductase Sdr
ANT_17380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ANT_17420	COG1609	Transcriptional regulator
ANT_17430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ANT_17440	COG1307	EDD domain protein, DegV family
ANT_17510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANT_17510	COG2070	2-Nitropropane dioxygenase
ANT_17520	COG0736	holo-[acyl-carrier-protein] synthase activity
ANT_17570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ANT_17600	COG1028	Short-chain dehydrogenase reductase Sdr
ANT_17620	COG1309	transcriptional regulator
ANT_17650	COG0371	Dehydrogenase
ANT_17660	COG0579	oxidoreductase
ANT_17670	COG0606	chelatase, subunit chli
ANT_17710	COG1216	Glycosyl transferase, family 2
ANT_17770	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ANT_17860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ANT_17870	COG0298	carbon dioxide binding
ANT_17890	COG0309	Hydrogenase expression formation protein (HypE)
ANT_17900	COG2226	methyltransferase
ANT_17910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ANT_17930	COG0822	iron-sulfur transferase activity
ANT_17940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ANT_17960	COG0719	Fe-S assembly protein
ANT_17970	COG0719	Fe-S assembly protein
ANT_17980	COG0396	ATPase activity
ANT_18000	COG2151	metal-sulfur cluster biosynthetic enzyme
ANT_18020	COG0598	Magnesium transport protein CorA
ANT_18030	COG1307	EDD domain protein, DegV family
ANT_18050	COG1940	carbohydrate kinase activity
ANT_18060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANT_18070	COG0698	ribose 5-phosphate isomerase
ANT_18090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ANT_18100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ANT_18110	COG0469	pyruvate kinase activity
ANT_18150	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANT_18150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANT_18170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ANT_18190	COG1774	PSP1 C-terminal conserved region
ANT_18200	COG0489	protein tyrosine kinase activity
ANT_18230	COG0649	NAD binding
ANT_18240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANT_18290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ANT_18310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANT_18320	COG0745	RESPONSE REGULATOR receiver
ANT_18330	COG0521	Mo-molybdopterin cofactor biosynthetic process
ANT_18360	COG0714	Associated with various cellular activities
ANT_18430	COG1872	DUF167
ANT_18440	COG0762	integral membrane protein
ANT_18450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ANT_18480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANT_18490	COG0785	Cytochrome C biogenesis protein
ANT_18500	COG1376	ErfK ybiS ycfS ynhG family protein
ANT_18510	COG2986	histidine ammonia-lyase
ANT_18530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ANT_18590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ANT_18600	COG3191	aminopeptidase activity
ANT_18610	COG1307	EDD domain protein, DegV family
ANT_18620	COG0667	Aldo Keto reductase
ANT_18640	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ANT_18690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANT_18700	COG5010	COG0457 FOG TPR repeat
ANT_18710	COG0105	UTP biosynthetic process
ANT_18720	COG1472	Belongs to the glycosyl hydrolase 3 family
ANT_18740	COG2706	6-phosphogluconolactonase activity
ANT_18760	COG1136	(ABC) transporter
ANT_18770	COG1136	(ABC) transporter
ANT_18830	COG0740	serine-type endopeptidase activity
ANT_18840	COG1621	beta-fructofuranosidase activity
ANT_18850	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ANT_18870	COG0517	IMP dehydrogenase activity
ANT_18900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ANT_18900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ANT_18910	COG2124	cytochrome p450
ANT_18940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ANT_18950	COG0222	ribosome binding
ANT_18960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ANT_18970	COG0081	regulation of translation
ANT_18980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ANT_18990	COG0250	Participates in transcription elongation, termination and antitermination
ANT_19010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ANT_19020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANT_19060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ANT_19070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ANT_19080	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANT_19090	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ANT_19140	COG0464	growth
ANT_19230	COG0681	Belongs to the peptidase S26 family
ANT_19240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ANT_19280	COG0149	triose-phosphate isomerase activity
ANT_19350	COG2205	protein histidine kinase activity
ANT_19360	COG0745	RESPONSE REGULATOR receiver
ANT_19390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ANT_19410	COG1131	(ABC) transporter
ANT_19420	COG2010	Cytochrome c
ANT_19480	COG1138	Cytochrome C-type biogenesis protein
ANT_19490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ANT_19500	COG0250	Participates in transcription elongation, termination and antitermination
ANT_19550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANT_19590	COG0557	exoribonuclease II activity
ANT_19600	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ANT_19660	COG0714	Associated with various cellular activities
ANT_19690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANT_19710	COG0572	uridine kinase
ANT_19830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANT_19840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ANT_19870	COG2255	four-way junction helicase activity
ANT_19880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ANT_19890	COG1573	uracil-dna glycosylase
ANT_19900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANT_19920	COG0750	zinc metalloprotease
ANT_19950	COG1254	Belongs to the acylphosphatase family
ANT_19970	COG0556	nucleotide-excision repair
ANT_19980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANT_20010	COG0318	PFAM AMP-dependent synthetase and ligase
ANT_20020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANT_20040	COG0367	asparagine synthase
ANT_20050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANT_20160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANT_20230	COG1215	transferase activity, transferring glycosyl groups
ANT_20240	COG1216	Glycosyl transferase, family 2
ANT_20280	COG0438	transferase activity, transferring glycosyl groups
ANT_20300	COG0297	glycogen (starch) synthase activity
ANT_20300	COG0438	transferase activity, transferring glycosyl groups
ANT_20320	COG0463	Glycosyl transferase, family 2
ANT_20360	COG0438	transferase activity, transferring glycosyl groups
ANT_20380	COG3944	biosynthesis protein
ANT_20400	COG2205	protein histidine kinase activity
ANT_20410	COG0745	RESPONSE REGULATOR receiver
ANT_20420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ANT_20460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ANT_20460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ANT_20530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ANT_20540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANT_20560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANT_20570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ANT_20580	COG0045	succinate-CoA ligase (ADP-forming) activity
ANT_20680	COG1040	competence protein
ANT_20690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ANT_20710	COG4478	integral membrane protein
ANT_20720	COG3842	ATPase activity
ANT_20750	COG1307	EDD domain protein, DegV family
ANT_20800	COG0215	cysteine-tRNA ligase activity
ANT_20820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ANT_20850	COG2226	methyltransferase
ANT_20860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ANT_20880	COG2318	DinB family
ANT_20890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANT_20900	COG0318	PFAM AMP-dependent synthetase and ligase
ANT_20910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ANT_20920	COG0792	nuclease activity
ANT_20930	COG0438	transferase activity, transferring glycosyl groups
ANT_20950	COG0735	belongs to the Fur family
ANT_20960	COG0803	Belongs to the bacterial solute-binding protein 9 family
ANT_20970	COG1121	(ABC) transporter
ANT_20980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ANT_21020	COG0697	spore germination
ANT_21040	COG0297	glycogen (starch) synthase activity
ANT_21050	COG0402	S-adenosylhomocysteine deaminase activity
ANT_21060	COG1058	Belongs to the CinA family
ANT_21060	COG1546	Belongs to the CinA family
ANT_21100	COG2855	membrane
ANT_21170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ANT_21200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANT_21400	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ANT_21660	COG4974	Belongs to the 'phage' integrase family
ANT_21770	COG1192	Involved in chromosome partitioning
ANT_21780	COG1192	Involved in chromosome partitioning
ANT_21800	COG1674	ftsk spoiiie
ANT_21880	COG0629	single-stranded DNA binding
ANT_21940	COG3005	denitrification pathway
ANT_21960	COG0823	Involved in the tonB-independent uptake of proteins
ANT_21990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ANT_22030	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ANT_22030	COG3261	NADH dehydrogenase
ANT_22040	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ANT_22040	COG3261	NADH dehydrogenase
ANT_22050	COG3260	NADH ubiquinone oxidoreductase 20
ANT_22080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANT_22090	COG0713	ATP synthesis coupled electron transport
ANT_22140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ANT_22150	COG1053	succinate dehydrogenase
ANT_22230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ANT_22270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ANT_22340	COG2211	Major facilitator Superfamily
ANT_22410	COG0360	Binds together with S18 to 16S ribosomal RNA
ANT_22420	COG0629	single-stranded DNA binding
ANT_22440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANT_22450	COG1196	nuclear chromosome segregation
ANT_22460	COG0571	ribonuclease III activity
ANT_22470	COG0314	molybdopterin synthase activity
ANT_22480	COG0315	cyclic pyranopterin monophosphate synthase activity
ANT_22490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ANT_22510	COG1028	Short-chain dehydrogenase reductase Sdr
ANT_22550	COG2313	pseudouridylate synthase activity
ANT_22560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANT_22590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ANT_22630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANT_22640	COG1215	transferase activity, transferring glycosyl groups
ANT_22650	COG5002	protein histidine kinase activity
ANT_22660	COG0745	RESPONSE REGULATOR receiver
ANT_22690	COG1132	(ABC) transporter
ANT_22700	COG1132	(ABC) transporter
ANT_22710	COG2045	Belongs to the ComB family
ANT_22780	COG1047	Peptidyl-prolyl cis-trans
ANT_22790	COG1271	oxidase subunit
ANT_22800	COG1294	oxidase, subunit
ANT_22850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ANT_22860	COG3706	GGDEF domain
ANT_22860	COG0745	RESPONSE REGULATOR receiver
ANT_22880	COG1215	transferase activity, transferring glycosyl groups
ANT_22890	COG1847	R3H domain protein
ANT_22900	COG0706	membrane insertase activity
ANT_22920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ANT_22930	COG0594	ribonuclease P activity
ANT_22940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ANT_22970	COG0531	amino acid
ANT_22980	COG1307	EDD domain protein, DegV family
ANT_23020	COG0823	Involved in the tonB-independent uptake of proteins
ANT_23030	COG4942	peptidase
ANT_23050	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ANT_23080	COG0701	Predicted permease
ANT_23100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ANT_23120	COG3764	Sortase (surface protein transpeptidase)
ANT_23140	COG0438	transferase activity, transferring glycosyl groups
ANT_23160	COG0419	ATPase involved in DNA repair
ANT_23160	COG0419	ATPase involved in DNA repair
ANT_23170	COG1253	flavin adenine dinucleotide binding
ANT_23200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ANT_23210	COG1984	allophanate hydrolase subunit 2
ANT_23220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ANT_23230	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ANT_23240	COG1606	tRNA processing
ANT_23250	COG1691	(AIR) carboxylase
ANT_23260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANT_23280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ANT_23300	COG2001	Belongs to the MraZ family
ANT_23310	COG0275	rRNA processing
ANT_23330	COG0768	penicillin binding
ANT_23340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ANT_23350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANT_23360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ANT_23370	COG0772	Belongs to the SEDS family
ANT_23380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANT_23400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANT_23420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ANT_23430	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANT_23460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ANT_23470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ANT_23590	COG3842	ATPase activity
ANT_23610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ANT_23660	COG0671	phosphoesterase, PA-phosphatase related
ANT_23680	COG0140	phosphoribosyl-ATP diphosphatase activity
ANT_23690	COG0140	phosphoribosyl-ATP diphosphatase activity
ANT_23690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ANT_23710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ANT_23720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ANT_23730	COG0131	Imidazoleglycerol-phosphate dehydratase
ANT_23740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANT_23750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ANT_23760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ANT_23780	COG3584	3D domain protein
ANT_23780	COG1388	LysM domain
ANT_24100	COG0740	serine-type endopeptidase activity
ANT_24280	COG4974	Belongs to the 'phage' integrase family
ANT_24350	COG1192	Involved in chromosome partitioning
ANT_24420	COG0629	single-stranded DNA binding
ANT_24510	COG1337	RAMP superfamily
ANT_24580	COG1518	maintenance of DNA repeat elements
ANT_24580	COG1468	defense response to virus
ANT_24670	COG0667	Aldo Keto reductase
ANT_24690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANT_24700	COG0012	GTP binding
ANT_24710	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ANT_24730	COG2226	methyltransferase
ANT_24740	COG0517	IMP dehydrogenase activity
ANT_24740	COG0516	GMP reductase activity
ANT_24780	COG0437	4 iron, 4 sulfur cluster binding
ANT_24790	COG0243	molybdopterin cofactor binding
ANT_24820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ANT_24830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ANT_24840	COG1404	Belongs to the peptidase S8 family
ANT_24850	COG1228	amidohydrolase
ANT_24870	COG1418	mRNA catabolic process
ANT_24890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANT_24900	COG1058	Belongs to the CinA family
ANT_24900	COG1546	Belongs to the CinA family
ANT_24910	COG1070	Carbohydrate kinase
ANT_24920	COG3458	cephalosporin-C deacetylase activity
ANT_24930	COG1609	Transcriptional regulator
ANT_24940	COG1554	hydrolase, family 65, central catalytic
ANT_24950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ANT_24970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ANT_24980	COG0072	phenylalanine-tRNA ligase activity
ANT_24990	COG2226	methyltransferase
ANT_25020	COG0667	Aldo Keto reductase
ANT_25030	COG2264	protein methyltransferase activity
ANT_25040	COG0484	heat shock protein binding
ANT_25050	COG0443	Heat shock 70 kDa protein
ANT_25060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ANT_25070	COG1420	regulation of RNA biosynthetic process
ANT_25080	COG0667	Aldo Keto reductase
ANT_25110	COG0009	L-threonylcarbamoyladenylate synthase
ANT_25120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ANT_25130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ANT_25140	COG0254	rRNA binding
ANT_25150	COG0736	holo-[acyl-carrier-protein] synthase activity
ANT_25170	COG0612	Peptidase, M16
ANT_25220	COG2703	oxygen carrier activity
ANT_25230	COG2379	hydroxypyruvate reductase
ANT_25250	COG1309	transcriptional regulator
ANT_25260	COG1620	l-lactate permease
ANT_25280	COG3239	Fatty acid desaturase
ANT_25290	COG0653	protein targeting
ANT_25330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANT_25340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANT_25380	COG2814	Major facilitator Superfamily
ANT_25400	COG1185	polyribonucleotide nucleotidyltransferase activity
ANT_25410	COG0504	CTP synthase activity
ANT_25420	COG0148	phosphopyruvate hydratase activity
ANT_25430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ANT_25460	COG3447	MASE1 domain protein
ANT_25460	COG5001	Diguanylate cyclase
ANT_25460	COG5002	protein histidine kinase activity
ANT_25470	COG0406	alpha-ribazole phosphatase activity
ANT_25470	COG0328	RNA-DNA hybrid ribonuclease activity
ANT_25480	COG1408	metallophosphoesterase
ANT_25510	COG0519	Catalyzes the synthesis of GMP from XMP
ANT_25510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANT_25520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ANT_25540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ANT_25540	COG1796	DNA polymerase
ANT_25550	COG0667	Aldo Keto reductase
ANT_25560	COG0517	IMP dehydrogenase activity
ANT_25590	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ANT_25600	COG1595	DNA-templated transcription, initiation
ANT_25620	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ANT_25630	COG3706	GGDEF domain
ANT_25640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ANT_25650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ANT_25660	COG2373	Large extracellular alpha-helical protein
ANT_25680	COG1597	lipid kinase activity
ANT_25700	COG5002	protein histidine kinase activity
ANT_25710	COG1668	transmembrane transport
ANT_25720	COG4555	ABC transporter
ANT_25730	COG1266	CAAX protease self-immunity
ANT_25780	COG4209	transmembrane transport
ANT_25790	COG0395	ABC-type sugar transport system, permease component
ANT_25830	COG1028	Short-chain dehydrogenase reductase Sdr
ANT_25840	COG0484	heat shock protein binding
ANT_25910	COG0728	peptidoglycan biosynthetic process
ANT_25940	COG0813	purine-nucleoside phosphorylase activity
ANT_25960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANT_26000	COG0433	COG0433 Predicted ATPase
ANT_26000	COG1674	ftsk spoiiie
ANT_26090	COG0438	transferase activity, transferring glycosyl groups
ANT_26100	COG0438	transferase activity, transferring glycosyl groups
ANT_26130	COG0438	transferase activity, transferring glycosyl groups
ANT_26140	COG1215	transferase activity, transferring glycosyl groups
ANT_26200	COG0367	asparagine synthase
ANT_26230	COG1570	exodeoxyribonuclease VII activity
ANT_26260	COG1404	Belongs to the peptidase S8 family
ANT_26270	COG0450	alkyl hydroperoxide reductase
ANT_26310	COG1609	Transcriptional regulator
ANT_26330	COG0395	ABC-type sugar transport system, permease component
ANT_26340	COG1175	transmembrane transport
ANT_26370	COG0395	ABC-type sugar transport system, permease component
ANT_26380	COG1175	transmembrane transport
ANT_26410	COG3459	Glycosyltransferase 36 associated
ANT_26430	COG1136	(ABC) transporter
ANT_26430	COG0577	efflux transmembrane transporter activity
ANT_26440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANT_26460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANT_26470	COG2848	UPF0210 protein
ANT_26490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANT_26560	COG0745	RESPONSE REGULATOR receiver
ANT_26570	COG2205	protein histidine kinase activity
ANT_26630	COG0667	Aldo Keto reductase
ANT_26660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ANT_26670	COG0459	protein refolding
ANT_26710	COG1980	fructose-bisphosphate aldolase activity
ANT_26750	COG1672	PFAM Archaeal ATPase
ANT_26750	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ANT_26770	COG0656	L-ascorbic acid biosynthetic process
ANT_26820	COG2608	mercury ion transmembrane transporter activity
ANT_26920	COG0735	belongs to the Fur family
ANT_26970	COG2864	formate dehydrogenase
ANT_26990	COG0071	Belongs to the small heat shock protein (HSP20) family
ANT_27030	COG4946	Tricorn protease homolog
ANT_27030	COG1506	peptidase
ANT_27030	COG0823	Involved in the tonB-independent uptake of proteins
ANT_27040	COG1216	Glycosyl transferase, family 2
ANT_27060	COG1136	(ABC) transporter
ANT_27070	COG0577	efflux transmembrane transporter activity
ANT_27070	COG1136	(ABC) transporter
ANT_27130	COG0592	DNA-directed DNA polymerase activity
ANT_27150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANT_27160	COG2197	response regulator
ANT_27190	COG1132	(ABC) transporter
ANT_27250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ANT_27330	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ANT_27350	COG1803	Methylglyoxal synthase
ANT_27410	COG0525	valine-tRNA ligase activity
ANT_27450	COG2770	Histidine kinase
ANT_27450	COG2208	phosphoserine phosphatase activity
ANT_27490	COG5001	Diguanylate cyclase
ANT_27510	COG1111	helicase
ANT_27510	COG1205	dead DEAH box helicase
ANT_27600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ANT_27610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ANT_27630	COG2920	part of a sulfur-relay system
ANT_27640	COG0446	pyridine nucleotide-disulphide oxidoreductase
ANT_27690	COG1216	Glycosyl transferase, family 2
ANT_27700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ANT_27720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANT_27730	COG0573	inorganic phosphate transmembrane transporter activity
ANT_27740	COG0581	inorganic phosphate transmembrane transporter activity
ANT_27750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANT_27760	COG0704	Plays a role in the regulation of phosphate uptake
ANT_27810	COG0667	Aldo Keto reductase
ANT_27820	COG0789	Transcriptional regulator
ANT_27870	COG2897	thiosulfate sulfurtransferase activity
ANT_27920	COG2921	Belongs to the UPF0250 family
ANT_27950	COG1063	alcohol dehydrogenase
ANT_27980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANT_27990	COG0745	RESPONSE REGULATOR receiver
ANT_28040	COG1744	ABC transporter substrate-binding protein PnrA-like
ANT_28070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ANT_28080	COG2197	response regulator
ANT_28120	COG1388	LysM domain
ANT_28120	COG1705	Flagellar rod assembly protein muramidase FlgJ
ANT_28140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ANT_28150	COG0728	peptidoglycan biosynthetic process
ANT_28210	COG0366	Alpha amylase catalytic
ANT_28240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ANT_28270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ANT_28280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ANT_28300	COG3706	GGDEF domain
ANT_28320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANT_28320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANT_28320	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANT_28320	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANT_28330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ANT_28330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ANT_28350	COG2359	stage V sporulation protein S
ANT_28360	COG1428	Deoxynucleoside kinase
ANT_28370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANT_28370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ANT_28400	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ANT_28430	COG1203	CRISPR-associated helicase, Cas3
ANT_28580	COG0395	ABC-type sugar transport system, permease component
ANT_28590	COG1175	transmembrane transport
ANT_28640	COG3459	Glycosyltransferase 36 associated
ANT_28660	COG1022	Amp-dependent synthetase and ligase
ANT_28670	COG1252	NADH dehydrogenase
ANT_28730	COG2205	protein histidine kinase activity
ANT_28750	COG3263	regulation of cellular component size
ANT_28760	COG3263	regulation of cellular component size
ANT_28810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ANT_28860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ANT_28870	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ANT_28890	COG0697	spore germination
ANT_28900	COG2169	Transcriptional regulator
ANT_28900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ANT_28910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ANT_28950	COG0659	secondary active sulfate transmembrane transporter activity
ANT_29010	COG0330	HflC and HflK could
ANT_29060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ANT_29070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANT_29120	COG0348	domain, Protein
ANT_29140	COG0730	response to heat
ANT_29190	COG0697	spore germination
ANT_29260	COG0438	transferase activity, transferring glycosyl groups
ANT_29290	COG0438	transferase activity, transferring glycosyl groups
ANT_29360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANT_29450	COG0583	DNA-binding transcription factor activity
ANT_29460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ANT_29590	COG0463	Glycosyl transferase, family 2
ANT_29660	COG0778	Nitroreductase
ANT_29670	COG1132	(ABC) transporter
ANT_29680	COG1132	(ABC) transporter
ANT_29690	COG3842	ATPase activity
ANT_29700	COG1178	ABC-type Fe3 transport system permease component
ANT_29710	COG1840	ABC-type Fe3 transport system, periplasmic component
ANT_29800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANT_29820	COG0517	IMP dehydrogenase activity
ANT_29840	COG0346	lactoylglutathione lyase activity
ANT_29880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ANT_29890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ANT_29910	COG0746	molybdenum cofactor guanylyltransferase activity
ANT_29920	COG3383	formate dehydrogenase (NAD+) activity
ANT_29930	COG2116	formate transmembrane transporter activity
ANT_30000	COG1193	negative regulation of DNA recombination
ANT_30010	COG3586	endonuclease activity
ANT_30040	COG0784	Response regulator, receiver
ANT_30070	COG0357	Ribosomal RNA small subunit methyltransferase G
ANT_30090	COG1234	tRNA 3'-trailer cleavage
ANT_30130	COG1376	ErfK ybiS ycfS ynhG family protein
ANT_30160	COG0156	8-amino-7-oxononanoate synthase activity
ANT_30170	COG0705	Rhomboid family
ANT_30170	COG0457	Tetratricopeptide repeat
ANT_30210	COG4585	Histidine kinase
ANT_30220	COG2197	response regulator
ANT_30260	COG0406	alpha-ribazole phosphatase activity
ANT_30280	COG0667	Aldo Keto reductase
ANT_30310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ANT_30310	COG2199	diguanylate cyclase activity
ANT_30320	COG2199	diguanylate cyclase activity
ANT_30320	COG2202	Pas domain
ANT_30320	COG2200	EAL domain
ANT_30340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANT_30340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANT_30410	COG0539	negative regulation of cytoplasmic translation
ANT_30420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANT_30490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANT_30500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ANT_30510	COG3118	belongs to the thioredoxin family
ANT_30520	COG3103	Sh3 type 3 domain protein
ANT_30520	COG0366	Alpha amylase catalytic
ANT_30550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANT_30560	COG0215	cysteine-tRNA ligase activity
ANT_30570	COG4956	integral membrane protein (PIN domain superfamily)
ANT_30620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ANT_30630	COG1606	tRNA processing
ANT_30660	COG3549	Plasmid maintenance system killer
ANT_30670	COG0443	Heat shock 70 kDa protein
ANT_30680	COG0626	cystathionine gamma-synthase activity
ANT_30870	COG0586	Pfam SNARE associated Golgi protein
ANT_30890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANT_30920	COG0747	negative chemotaxis
ANT_31010	COG0528	UMP kinase activity
ANT_31020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ANT_31030	COG0052	Belongs to the universal ribosomal protein uS2 family
ANT_31120	COG2198	Histidine kinase
ANT_31120	COG0643	Histidine kinase
ANT_31130	COG0835	chemotaxis
ANT_31140	COG0840	transmembrane signaling receptor activity
ANT_31170	COG2201	protein-glutamate methylesterase activity
ANT_31180	COG2204	response regulator
ANT_31200	COG5002	protein histidine kinase activity
ANT_31210	COG3706	GGDEF domain
ANT_31230	COG2201	protein-glutamate methylesterase activity
ANT_31250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANT_31260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANT_31290	COG4942	peptidase
ANT_31290	COG1388	LysM domain
ANT_31300	COG3842	ATPase activity
ANT_31320	COG3833	ABC-type maltose transport systems, permease component
ANT_31340	COG0724	RNA recognition motif
ANT_31360	COG0823	Involved in the tonB-independent uptake of proteins
ANT_31410	COG4133	protoheme IX ABC transporter activity
ANT_31440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANT_31460	COG0438	transferase activity, transferring glycosyl groups
ANT_31540	COG0667	Aldo Keto reductase
ANT_31550	COG0242	peptide deformylase activity
ANT_31560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANT_31570	COG3706	GGDEF domain
ANT_31620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANT_31640	COG1573	uracil-dna glycosylase
ANT_31650	COG0456	acetyltransferase
ANT_31660	COG1214	PFAM Peptidase M22, glycoprotease
ANT_31670	COG0802	atpase or kinase
ANT_31720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ANT_31760	COG1428	Deoxynucleoside kinase