locus-tag	class	description
A2cp1_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A2cp1_0002	COG0592	DNA-directed DNA polymerase activity
A2cp1_0005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A2cp1_0008	COG2181	nitrate reductase activity
A2cp1_0008	COG0247	lactate metabolic process
A2cp1_0011	COG0189	ligase activity
A2cp1_0012	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A2cp1_0013	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A2cp1_0014	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A2cp1_0019	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A2cp1_0027	COG3436	PFAM IS66 Orf2 family protein
A2cp1_0036	COG3852	Histidine kinase
A2cp1_0039	COG0442	prolyl-tRNA aminoacylation
A2cp1_0045	COG0840	transmembrane signaling receptor activity
A2cp1_0046	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_0049	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2cp1_0052	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A2cp1_0054	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A2cp1_0057	COG0280	phosphate acetyltransferase
A2cp1_0058	COG3426	butyrate kinase activity
A2cp1_0059	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2cp1_0064	COG2086	electron transfer activity
A2cp1_0066	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2cp1_0067	COG0861	Integral membrane protein TerC family
A2cp1_0072	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A2cp1_0072	COG1793	dna ligase
A2cp1_0073	COG0564	pseudouridine synthase activity
A2cp1_0077	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2cp1_0078	COG0805	protein transport
A2cp1_0080	COG0183	Belongs to the thiolase family
A2cp1_0084	COG1032	radical SAM domain protein
A2cp1_0087	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A2cp1_0093	COG0352	thiamine-phosphate diphosphorylase activity
A2cp1_0094	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A2cp1_0095	COG0351	phosphomethylpyrimidine kinase
A2cp1_0095	COG0352	thiamine-phosphate diphosphorylase activity
A2cp1_0095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A2cp1_0097	COG0305	Participates in initiation and elongation during chromosome replication
A2cp1_0099	COG1346	cytolysis
A2cp1_0101	COG0583	DNA-binding transcription factor activity
A2cp1_0102	COG0646	methionine synthase
A2cp1_0102	COG1410	methionine synthase
A2cp1_0107	COG0433	COG0433 Predicted ATPase
A2cp1_0116	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A2cp1_0117	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2cp1_0119	COG3706	GGDEF domain
A2cp1_0119	COG0745	RESPONSE REGULATOR receiver
A2cp1_0120	COG0612	Peptidase, M16
A2cp1_0121	COG0612	Peptidase, M16
A2cp1_0124	COG2204	response regulator
A2cp1_0125	COG3852	Histidine kinase
A2cp1_0130	COG1077	Cell shape determining protein MreB Mrl
A2cp1_0131	COG1077	Cell shape determining protein MreB Mrl
A2cp1_0132	COG0823	Involved in the tonB-independent uptake of proteins
A2cp1_0132	COG1506	peptidase
A2cp1_0136	COG0360	Binds together with S18 to 16S ribosomal RNA
A2cp1_0139	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A2cp1_0144	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A2cp1_0145	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A2cp1_0150	COG3706	GGDEF domain
A2cp1_0162	COG2204	response regulator
A2cp1_0164	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A2cp1_0166	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2cp1_0166	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2cp1_0169	COG3716	PTS system mannose fructose sorbose family IID component
A2cp1_0170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2cp1_0174	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A2cp1_0177	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A2cp1_0177	COG0662	Cupin 2, conserved barrel domain protein
A2cp1_0179	COG1940	carbohydrate kinase activity
A2cp1_0179	COG1846	Transcriptional regulator
A2cp1_0191	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A2cp1_0199	COG3138	arginine N-succinyltransferase
A2cp1_0200	COG1490	D-aminoacyl-tRNA deacylase activity
A2cp1_0201	COG0537	adenosine 5'-monophosphoramidase activity
A2cp1_0209	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A2cp1_0211	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A2cp1_0218	COG0564	pseudouridine synthase activity
A2cp1_0224	COG0109	protoheme IX farnesyltransferase activity
A2cp1_0224	COG1612	heme a metabolic process
A2cp1_0230	COG2814	Major facilitator Superfamily
A2cp1_0235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A2cp1_0238	COG2226	methyltransferase
A2cp1_0239	COG0697	spore germination
A2cp1_0241	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2cp1_0241	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2cp1_0241	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2cp1_0250	COG1309	transcriptional regulator
A2cp1_0257	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A2cp1_0262	COG3070	regulator of competence-specific genes
A2cp1_0263	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2cp1_0265	COG1297	OPT oligopeptide transporter protein
A2cp1_0266	COG0745	RESPONSE REGULATOR receiver
A2cp1_0267	COG2264	protein methyltransferase activity
A2cp1_0268	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A2cp1_0271	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A2cp1_0273	COG1278	Cold shock
A2cp1_0276	COG0204	Acyl-transferase
A2cp1_0278	COG5002	protein histidine kinase activity
A2cp1_0279	COG0439	Biotin carboxylase
A2cp1_0280	COG0511	ligase activity, forming carbon-carbon bonds
A2cp1_0280	COG5016	pyruvate
A2cp1_0287	COG0564	pseudouridine synthase activity
A2cp1_0288	COG0848	biopolymer transport protein
A2cp1_0290	COG0811	peptide transport
A2cp1_0295	COG0052	Belongs to the universal ribosomal protein uS2 family
A2cp1_0298	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2cp1_0298	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A2cp1_0299	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A2cp1_0300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2cp1_0301	COG0617	tRNA 3'-terminal CCA addition
A2cp1_0302	COG0528	UMP kinase activity
A2cp1_0307	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A2cp1_0307	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A2cp1_0313	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2cp1_0314	COG2062	phosphohistidine phosphatase, SixA
A2cp1_0316	COG1640	4-alpha-glucanotransferase
A2cp1_0317	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A2cp1_0321	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A2cp1_0323	COG3852	Histidine kinase
A2cp1_0325	COG2839	Protein conserved in bacteria
A2cp1_0332	COG1942	4-Oxalocrotonate Tautomerase
A2cp1_0333	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A2cp1_0334	COG0583	DNA-binding transcription factor activity
A2cp1_0344	COG3291	Pkd domain containing protein
A2cp1_0344	COG4412	M6 family metalloprotease domain protein
A2cp1_0347	COG0308	aminopeptidase N
A2cp1_0348	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2cp1_0351	COG2151	metal-sulfur cluster biosynthetic enzyme
A2cp1_0355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2cp1_0363	COG4206	TonB-dependent receptor
A2cp1_0367	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2cp1_0369	COG0840	transmembrane signaling receptor activity
A2cp1_0376	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A2cp1_0378	COG2855	membrane
A2cp1_0379	COG0583	DNA-binding transcription factor activity
A2cp1_0383	COG1595	DNA-templated transcription, initiation
A2cp1_0388	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2cp1_0388	COG1024	Enoyl-CoA hydratase
A2cp1_0389	COG0183	Belongs to the thiolase family
A2cp1_0390	COG1960	acyl-CoA dehydrogenase activity
A2cp1_0395	COG2890	protein-(glutamine-N5) methyltransferase activity
A2cp1_0399	COG0402	S-adenosylhomocysteine deaminase activity
A2cp1_0400	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A2cp1_0401	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A2cp1_0402	COG0163	prenyltransferase activity
A2cp1_0403	COG2226	methyltransferase
A2cp1_0404	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A2cp1_0406	COG0612	Peptidase, M16
A2cp1_0414	COG0542	response to heat
A2cp1_0415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2cp1_0418	COG0318	PFAM AMP-dependent synthetase and ligase
A2cp1_0419	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2cp1_0419	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A2cp1_0430	COG1234	tRNA 3'-trailer cleavage
A2cp1_0431	COG1741	Belongs to the pirin family
A2cp1_0433	COG1131	(ABC) transporter
A2cp1_0436	COG0183	Belongs to the thiolase family
A2cp1_0437	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2cp1_0437	COG1024	Enoyl-CoA hydratase
A2cp1_0439	COG5002	protein histidine kinase activity
A2cp1_0440	COG0745	RESPONSE REGULATOR receiver
A2cp1_0441	COG1921	L-seryl-tRNASec selenium transferase activity
A2cp1_0442	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2cp1_0447	COG3852	Histidine kinase
A2cp1_0449	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2cp1_0450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A2cp1_0452	COG1088	dTDP-glucose 4,6-dehydratase activity
A2cp1_0453	COG0204	Acyl-transferase
A2cp1_0455	COG1846	Transcriptional regulator
A2cp1_0458	COG3706	GGDEF domain
A2cp1_0463	COG0420	3'-5' exonuclease activity
A2cp1_0470	COG1136	(ABC) transporter
A2cp1_0470	COG0577	efflux transmembrane transporter activity
A2cp1_0476	COG1309	transcriptional regulator
A2cp1_0478	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A2cp1_0480	COG0667	Aldo Keto reductase
A2cp1_0484	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A2cp1_0484	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A2cp1_0485	COG3639	organic phosphonate transmembrane transporter activity
A2cp1_0486	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A2cp1_0496	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A2cp1_0497	COG3875	lactate racemase activity
A2cp1_0503	COG0298	carbon dioxide binding
A2cp1_0504	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A2cp1_0506	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A2cp1_0507	COG5557	Pfam Polysulphide reductase, NrfD
A2cp1_0508	COG0437	4 iron, 4 sulfur cluster binding
A2cp1_0509	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A2cp1_0515	COG1285	pathogenesis
A2cp1_0516	COG2119	membrane
A2cp1_0521	COG1122	ATPase activity
A2cp1_0523	COG0310	cobalt ion transport
A2cp1_0526	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A2cp1_0526	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2cp1_0532	COG2205	protein histidine kinase activity
A2cp1_0535	COG5002	protein histidine kinase activity
A2cp1_0536	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A2cp1_0536	COG0493	'glutamate synthase
A2cp1_0538	COG2133	pyrroloquinoline quinone binding
A2cp1_0539	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A2cp1_0545	COG1538	Outer membrane efflux protein
A2cp1_0548	COG1309	transcriptional regulator
A2cp1_0549	COG0366	Alpha amylase catalytic
A2cp1_0551	COG0596	Alpha beta hydrolase
A2cp1_0553	COG2832	Protein of unknown function (DUF454)
A2cp1_0559	COG0671	phosphoesterase, PA-phosphatase related
A2cp1_0560	COG1752	Esterase of the alpha-beta hydrolase superfamily
A2cp1_0562	COG0436	Aminotransferase
A2cp1_0564	COG3047	cAMP biosynthetic process
A2cp1_0565	COG4191	Histidine kinase
A2cp1_0567	COG1122	ATPase activity
A2cp1_0568	COG1268	BioY protein
A2cp1_0569	COG0400	carboxylic ester hydrolase activity
A2cp1_0578	COG0596	Alpha beta hydrolase
A2cp1_0579	COG0583	DNA-binding transcription factor activity
A2cp1_0581	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_0592	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A2cp1_0593	COG3177	Filamentation induced by cAMP protein fic
A2cp1_0594	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A2cp1_0596	COG1228	amidohydrolase
A2cp1_0597	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A2cp1_0598	COG2204	response regulator
A2cp1_0603	COG0612	Peptidase, M16
A2cp1_0604	COG5002	protein histidine kinase activity
A2cp1_0610	COG2084	Dehydrogenase
A2cp1_0614	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A2cp1_0615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A2cp1_0617	COG4232	protein-disulfide reductase activity
A2cp1_0620	COG0316	Belongs to the HesB IscA family
A2cp1_0621	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A2cp1_0622	COG0443	Heat shock 70 kDa protein
A2cp1_0625	COG2201	protein-glutamate methylesterase activity
A2cp1_0627	COG0835	chemotaxis
A2cp1_0628	COG0643	Histidine kinase
A2cp1_0628	COG2198	Histidine kinase
A2cp1_0629	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A2cp1_0631	COG0745	RESPONSE REGULATOR receiver
A2cp1_0634	COG0745	RESPONSE REGULATOR receiver
A2cp1_0639	COG2201	protein-glutamate methylesterase activity
A2cp1_0641	COG0784	Response regulator, receiver
A2cp1_0643	COG0275	rRNA processing
A2cp1_0646	COG0438	transferase activity, transferring glycosyl groups
A2cp1_0651	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A2cp1_0652	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A2cp1_0654	COG0295	cytidine deaminase activity
A2cp1_0655	COG0196	riboflavin kinase activity
A2cp1_0656	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2cp1_0659	COG3852	Histidine kinase
A2cp1_0669	COG4968	Prepilin-type N-terminal cleavage methylation domain
A2cp1_0670	COG1131	(ABC) transporter
A2cp1_0671	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A2cp1_0673	COG2204	response regulator
A2cp1_0675	COG0849	cell division
A2cp1_0682	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A2cp1_0683	COG0511	ligase activity, forming carbon-carbon bonds
A2cp1_0684	COG0439	Biotin carboxylase
A2cp1_0687	COG3267	Type II secretory pathway component ExeA
A2cp1_0687	COG3409	Peptidoglycan-binding domain 1 protein
A2cp1_0690	COG2217	Heavy metal translocating P-type atpase
A2cp1_0699	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A2cp1_0701	COG2884	Cell division ATP-binding protein ftsE
A2cp1_0702	COG2177	Part of the ABC transporter FtsEX involved in
A2cp1_0703	COG4942	peptidase
A2cp1_0704	COG0793	Belongs to the peptidase S41A family
A2cp1_0705	COG1215	transferase activity, transferring glycosyl groups
A2cp1_0707	COG0546	phosphoglycolate phosphatase activity
A2cp1_0708	COG0552	protein localization to endoplasmic reticulum
A2cp1_0709	COG1196	nuclear chromosome segregation
A2cp1_0710	COG3290	protein histidine kinase activity
A2cp1_0710	COG0840	transmembrane signaling receptor activity
A2cp1_0717	COG2165	general secretion pathway protein
A2cp1_0720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2cp1_0721	COG1450	Type ii and iii secretion system protein
A2cp1_0725	COG0254	rRNA binding
A2cp1_0726	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2cp1_0730	COG1254	Belongs to the acylphosphatase family
A2cp1_0732	COG1530	ribonuclease E activity
A2cp1_0732	COG1530	ribonuclease E activity
A2cp1_0733	COG1295	ribonuclease BN
A2cp1_0734	COG0776	regulation of translation
A2cp1_0735	COG4789	Type iii secretion
A2cp1_0738	COG4794	Type iii secretion
A2cp1_0741	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A2cp1_0748	COG2197	response regulator
A2cp1_0749	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A2cp1_0751	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A2cp1_0753	COG0107	imidazoleglycerol-phosphate synthase activity
A2cp1_0760	COG0406	alpha-ribazole phosphatase activity
A2cp1_0760	COG0328	RNA-DNA hybrid ribonuclease activity
A2cp1_0761	COG1584	GPR1 FUN34 yaaH family protein
A2cp1_0762	COG0242	peptide deformylase activity
A2cp1_0764	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A2cp1_0767	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A2cp1_0768	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A2cp1_0769	COG0497	DNA recombination
A2cp1_0770	COG0631	protein serine/threonine phosphatase activity
A2cp1_0771	COG0739	heme binding
A2cp1_0773	COG0653	protein targeting
A2cp1_0778	COG1203	CRISPR-associated helicase, Cas3
A2cp1_0784	COG1518	maintenance of DNA repeat elements
A2cp1_0793	COG1595	DNA-templated transcription, initiation
A2cp1_0798	COG0628	permease
A2cp1_0801	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A2cp1_0803	COG0739	heme binding
A2cp1_0807	COG1881	PFAM PEBP family protein
A2cp1_0810	COG0348	domain, Protein
A2cp1_0812	COG0589	response to stress
A2cp1_0813	COG0167	dihydroorotate dehydrogenase activity
A2cp1_0817	COG0247	lactate metabolic process
A2cp1_0828	COG0745	RESPONSE REGULATOR receiver
A2cp1_0830	COG1253	flavin adenine dinucleotide binding
A2cp1_0832	COG2264	protein methyltransferase activity
A2cp1_0834	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2cp1_0839	COG1643	Atp-dependent helicase
A2cp1_0840	COG0071	Belongs to the small heat shock protein (HSP20) family
A2cp1_0842	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A2cp1_0846	COG1595	DNA-templated transcription, initiation
A2cp1_0848	COG0437	4 iron, 4 sulfur cluster binding
A2cp1_0855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A2cp1_0860	COG0028	Belongs to the TPP enzyme family
A2cp1_0861	COG4948	Mandelate Racemase Muconate Lactonizing
A2cp1_0862	COG0247	lactate metabolic process
A2cp1_0862	COG0277	FAD linked oxidase domain protein
A2cp1_0863	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A2cp1_0865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2cp1_0868	COG1793	dna ligase
A2cp1_0869	COG0069	glutamate synthase activity
A2cp1_0869	COG0067	glutamate synthase
A2cp1_0869	COG0070	glutamate synthase
A2cp1_0870	COG0493	'glutamate synthase
A2cp1_0873	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2cp1_0875	COG0437	4 iron, 4 sulfur cluster binding
A2cp1_0878	COG3973	AAA domain
A2cp1_0879	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A2cp1_0880	COG0488	(ABC) transporter
A2cp1_0881	COG1012	belongs to the aldehyde dehydrogenase family
A2cp1_0883	COG2204	response regulator
A2cp1_0884	COG4191	Histidine kinase
A2cp1_0885	COG1131	(ABC) transporter
A2cp1_0886	COG0842	Transport permease protein
A2cp1_0888	COG0514	ATP-dependent DNA helicase (RecQ)
A2cp1_0891	COG4681	YaeQ
A2cp1_0893	COG0719	Fe-S assembly protein
A2cp1_0894	COG0396	ATPase activity
A2cp1_0895	COG0719	Fe-S assembly protein
A2cp1_0896	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A2cp1_0901	COG0793	Belongs to the peptidase S41A family
A2cp1_0903	COG1136	(ABC) transporter
A2cp1_0903	COG0577	efflux transmembrane transporter activity
A2cp1_0904	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2cp1_0906	COG2197	response regulator
A2cp1_0909	COG0023	Translation Initiation Factor
A2cp1_0912	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2cp1_0913	COG0058	SHG alpha-glucan phosphorylase activity
A2cp1_0916	COG1704	LemA family
A2cp1_0921	COG1396	sequence-specific DNA binding
A2cp1_0922	COG0745	RESPONSE REGULATOR receiver
A2cp1_0927	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A2cp1_0938	COG0668	transmembrane transport
A2cp1_0942	COG0745	RESPONSE REGULATOR receiver
A2cp1_0943	COG2205	protein histidine kinase activity
A2cp1_0945	COG0531	amino acid
A2cp1_0949	COG2322	membrane
A2cp1_0952	COG0109	protoheme IX farnesyltransferase activity
A2cp1_0955	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A2cp1_0959	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A2cp1_0961	COG0243	molybdopterin cofactor binding
A2cp1_0963	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A2cp1_0965	COG2132	Multicopper oxidase
A2cp1_0980	COG2873	o-acetylhomoserine
A2cp1_0983	COG0432	Pfam Uncharacterised protein family UPF0047
A2cp1_0984	COG0003	Pfam Anion-transporting ATPase
A2cp1_0987	COG1192	Involved in chromosome partitioning
A2cp1_0990	COG3384	dioxygenase
A2cp1_0991	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A2cp1_0994	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2cp1_0995	COG0584	glycerophosphoryl diester phosphodiesterase
A2cp1_0997	COG1271	oxidase subunit
A2cp1_0998	COG1294	oxidase, subunit
A2cp1_1001	COG1331	Highly conserved protein containing a thioredoxin domain
A2cp1_1006	COG0534	Mate efflux family protein
A2cp1_1008	COG2814	Major facilitator Superfamily
A2cp1_1013	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A2cp1_1020	COG1793	dna ligase
A2cp1_1020	COG3285	dna ligase
A2cp1_1024	COG0427	acetyl-CoA hydrolase
A2cp1_1026	COG0745	RESPONSE REGULATOR receiver
A2cp1_1028	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2cp1_1034	COG3604	Transcriptional regulator
A2cp1_1035	COG2814	Major facilitator Superfamily
A2cp1_1044	COG2205	protein histidine kinase activity
A2cp1_1046	COG4783	chaperone-mediated protein folding
A2cp1_1049	COG1278	Cold shock
A2cp1_1052	COG1720	tRNA m6t6A37 methyltransferase activity
A2cp1_1057	COG0454	-acetyltransferase
A2cp1_1057	COG0456	acetyltransferase
A2cp1_1059	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A2cp1_1066	COG1129	ABC transporter
A2cp1_1067	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A2cp1_1077	COG0438	transferase activity, transferring glycosyl groups
A2cp1_1078	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A2cp1_1084	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2cp1_1085	COG0798	PFAM Bile acid sodium symporter
A2cp1_1091	COG2226	methyltransferase
A2cp1_1103	COG1196	nuclear chromosome segregation
A2cp1_1120	COG0714	Associated with various cellular activities
A2cp1_1122	COG2003	Belongs to the UPF0758 family
A2cp1_1123	COG1475	DNA binding
A2cp1_1143	COG3504	Conjugal transfer protein
A2cp1_1160	COG1201	RNA secondary structure unwinding
A2cp1_1166	COG1335	isochorismatase
A2cp1_1167	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A2cp1_1170	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A2cp1_1172	COG1692	metallophosphoesterase
A2cp1_1175	COG1104	cysteine desulfurase activity
A2cp1_1177	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A2cp1_1181	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A2cp1_1183	COG2204	response regulator
A2cp1_1189	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2cp1_1191	COG0673	inositol 2-dehydrogenase activity
A2cp1_1192	COG0438	transferase activity, transferring glycosyl groups
A2cp1_1195	COG1132	(ABC) transporter
A2cp1_1197	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2cp1_1198	COG4221	oxidoreductase activity
A2cp1_1199	COG5000	phosphorelay sensor kinase activity
A2cp1_1204	COG1543	Belongs to the glycosyl hydrolase 57 family
A2cp1_1208	COG1136	(ABC) transporter
A2cp1_1209	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A2cp1_1214	COG3494	Protein of unknown function (DUF1009)
A2cp1_1216	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A2cp1_1217	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2cp1_1218	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A2cp1_1219	COG0484	heat shock protein binding
A2cp1_1221	COG1570	exodeoxyribonuclease VII activity
A2cp1_1222	COG1722	exodeoxyribonuclease VII activity
A2cp1_1223	COG0745	RESPONSE REGULATOR receiver
A2cp1_1224	COG0142	geranyltranstransferase activity
A2cp1_1226	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A2cp1_1233	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A2cp1_1237	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A2cp1_1239	COG5002	protein histidine kinase activity
A2cp1_1243	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2cp1_1245	COG0546	phosphoglycolate phosphatase activity
A2cp1_1247	COG0745	RESPONSE REGULATOR receiver
A2cp1_1249	COG0750	zinc metalloprotease
A2cp1_1250	COG2078	PFAM AMMECR1 domain protein
A2cp1_1251	COG2816	NAD+ diphosphatase activity
A2cp1_1259	COG5002	protein histidine kinase activity
A2cp1_1261	COG1960	acyl-CoA dehydrogenase activity
A2cp1_1262	COG1324	tolerance protein
A2cp1_1264	COG0515	serine threonine protein kinase
A2cp1_1266	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2cp1_1267	COG0616	signal peptide processing
A2cp1_1268	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A2cp1_1269	COG1607	acyl-coa hydrolase
A2cp1_1273	COG1408	metallophosphoesterase
A2cp1_1278	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A2cp1_1279	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A2cp1_1284	COG1100	Small GTP-binding protein
A2cp1_1286	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A2cp1_1289	COG4974	Belongs to the 'phage' integrase family
A2cp1_1302	COG1802	Transcriptional regulator
A2cp1_1302	COG4626	Terminase
A2cp1_1304	COG0740	serine-type endopeptidase activity
A2cp1_1321	COG2226	methyltransferase
A2cp1_1322	COG0840	transmembrane signaling receptor activity
A2cp1_1323	COG1064	alcohol dehydrogenase
A2cp1_1326	COG0318	PFAM AMP-dependent synthetase and ligase
A2cp1_1327	COG3875	lactate racemase activity
A2cp1_1331	COG0243	molybdopterin cofactor binding
A2cp1_1332	COG3278	Belongs to the heme-copper respiratory oxidase family
A2cp1_1336	COG0348	domain, Protein
A2cp1_1341	COG1049	propionate catabolic process, 2-methylcitrate cycle
A2cp1_1346	COG0114	fumarate hydratase activity
A2cp1_1350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A2cp1_1355	COG1355	regulation of microtubule-based process
A2cp1_1359	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A2cp1_1361	COG0443	Heat shock 70 kDa protein
A2cp1_1362	COG0484	heat shock protein binding
A2cp1_1364	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A2cp1_1365	COG0010	Belongs to the arginase family
A2cp1_1366	COG1959	2 iron, 2 sulfur cluster binding
A2cp1_1367	COG0613	PHP domain protein
A2cp1_1368	COG1007	ATP synthesis coupled electron transport
A2cp1_1371	COG0713	ATP synthesis coupled electron transport
A2cp1_1373	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2cp1_1374	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A2cp1_1376	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2cp1_1378	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2cp1_1381	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2cp1_1384	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A2cp1_1385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2cp1_1388	COG2223	nitrite transmembrane transporter activity
A2cp1_1389	COG1796	DNA polymerase
A2cp1_1389	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A2cp1_1391	COG0521	Mo-molybdopterin cofactor biosynthetic process
A2cp1_1395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A2cp1_1398	COG0011	TIGRFAM Protein of
A2cp1_1403	COG1509	lysine 2,3-aminomutase activity
A2cp1_1404	COG0586	Pfam SNARE associated Golgi protein
A2cp1_1405	COG2385	sporulation resulting in formation of a cellular spore
A2cp1_1408	COG0343	queuine tRNA-ribosyltransferase activity
A2cp1_1409	COG1862	Preprotein translocase
A2cp1_1410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2cp1_1411	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2cp1_1415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A2cp1_1415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A2cp1_1416	COG0604	alcohol dehydrogenase
A2cp1_1419	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A2cp1_1424	COG1597	lipid kinase activity
A2cp1_1426	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A2cp1_1427	COG0612	Peptidase, M16
A2cp1_1431	COG0783	Belongs to the Dps family
A2cp1_1435	COG0352	thiamine-phosphate diphosphorylase activity
A2cp1_1439	COG1074	ATP-dependent DNA helicase activity
A2cp1_1441	COG1830	Aldolase
A2cp1_1449	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A2cp1_1451	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2cp1_1454	COG0768	penicillin binding
A2cp1_1455	COG0772	Belongs to the SEDS family
A2cp1_1456	COG3118	belongs to the thioredoxin family
A2cp1_1459	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A2cp1_1460	COG0181	hydroxymethylbilane synthase activity
A2cp1_1463	COG0585	pseudouridine synthase activity
A2cp1_1464	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2cp1_1467	COG0587	DNA-directed DNA polymerase activity
A2cp1_1474	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A2cp1_1475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2cp1_1476	COG0446	pyridine nucleotide-disulphide oxidoreductase
A2cp1_1476	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2cp1_1479	COG0312	modulator of DNA gyrase
A2cp1_1497	COG1216	Glycosyl transferase, family 2
A2cp1_1500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2cp1_1501	COG0009	L-threonylcarbamoyladenylate synthase
A2cp1_1503	COG0113	porphobilinogen synthase activity
A2cp1_1506	COG1181	Belongs to the D-alanine--D-alanine ligase family
A2cp1_1514	COG2205	protein histidine kinase activity
A2cp1_1515	COG2201	protein-glutamate methylesterase activity
A2cp1_1523	COG0745	RESPONSE REGULATOR receiver
A2cp1_1526	COG0557	exoribonuclease II activity
A2cp1_1528	COG0730	response to heat
A2cp1_1529	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A2cp1_1531	COG0411	ABC transporter
A2cp1_1533	COG0559	Belongs to the binding-protein-dependent transport system permease family
A2cp1_1536	COG1193	negative regulation of DNA recombination
A2cp1_1543	COG1595	DNA-templated transcription, initiation
A2cp1_1547	COG3876	Protein conserved in bacteria
A2cp1_1551	COG0542	response to heat
A2cp1_1556	COG4263	nitrous-oxide reductase activity
A2cp1_1562	COG1752	Esterase of the alpha-beta hydrolase superfamily
A2cp1_1565	COG0459	protein refolding
A2cp1_1566	COG3706	GGDEF domain
A2cp1_1569	COG0525	valine-tRNA ligase activity
A2cp1_1571	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A2cp1_1571	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A2cp1_1575	COG0728	peptidoglycan biosynthetic process
A2cp1_1581	COG1595	DNA-templated transcription, initiation
A2cp1_1583	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2cp1_1589	COG1573	uracil-dna glycosylase
A2cp1_1591	COG0330	HflC and HflK could
A2cp1_1594	COG0183	Belongs to the thiolase family
A2cp1_1595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A2cp1_1599	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A2cp1_1607	COG0501	Belongs to the peptidase M48B family
A2cp1_1611	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A2cp1_1613	COG0586	Pfam SNARE associated Golgi protein
A2cp1_1614	COG0443	Heat shock 70 kDa protein
A2cp1_1615	COG0517	IMP dehydrogenase activity
A2cp1_1615	COG0516	GMP reductase activity
A2cp1_1616	COG0519	Catalyzes the synthesis of GMP from XMP
A2cp1_1616	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A2cp1_1620	COG2204	response regulator
A2cp1_1622	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A2cp1_1624	COG3746	phosphate-selective porin O and P
A2cp1_1626	COG1121	(ABC) transporter
A2cp1_1628	COG1811	Na channel or pump
A2cp1_1631	COG2226	methyltransferase
A2cp1_1633	COG0436	Aminotransferase
A2cp1_1638	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2cp1_1641	COG1234	tRNA 3'-trailer cleavage
A2cp1_1643	COG0300	oxidoreductase activity
A2cp1_1644	COG5322	oxidoreductase activity
A2cp1_1644	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2cp1_1645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A2cp1_1646	COG0243	molybdopterin cofactor binding
A2cp1_1654	COG0596	Alpha beta hydrolase
A2cp1_1660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2cp1_1665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2cp1_1666	COG4654	Cytochrome c, class I
A2cp1_1671	COG2010	Cytochrome c
A2cp1_1672	COG0737	Belongs to the 5'-nucleotidase family
A2cp1_1673	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2cp1_1677	COG1845	cytochrome c oxidase, subunit III
A2cp1_1677	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A2cp1_1681	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2cp1_1690	COG0443	Heat shock 70 kDa protein
A2cp1_1693	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A2cp1_1693	COG0392	lysyltransferase activity
A2cp1_1696	COG1595	DNA-templated transcription, initiation
A2cp1_1707	COG4191	Histidine kinase
A2cp1_1708	COG2204	response regulator
A2cp1_1711	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2cp1_1720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A2cp1_1722	COG0039	L-malate dehydrogenase activity
A2cp1_1729	COG0004	ammonium transporteR
A2cp1_1733	COG0583	DNA-binding transcription factor activity
A2cp1_1734	COG2814	Major facilitator Superfamily
A2cp1_1735	COG0583	DNA-binding transcription factor activity
A2cp1_1737	COG2205	protein histidine kinase activity
A2cp1_1738	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A2cp1_1740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A2cp1_1745	COG0583	DNA-binding transcription factor activity
A2cp1_1746	COG3118	belongs to the thioredoxin family
A2cp1_1751	COG0583	DNA-binding transcription factor activity
A2cp1_1754	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2cp1_1755	COG1592	Rubrerythrin
A2cp1_1756	COG2205	protein histidine kinase activity
A2cp1_1762	COG0840	transmembrane signaling receptor activity
A2cp1_1763	COG0835	chemotaxis
A2cp1_1767	COG0410	ABC transporter
A2cp1_1770	COG0683	leucine binding
A2cp1_1773	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A2cp1_1775	COG2223	nitrite transmembrane transporter activity
A2cp1_1778	COG1140	nitrate reductase beta subunit
A2cp1_1779	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A2cp1_1781	COG4191	Histidine kinase
A2cp1_1790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2cp1_1792	COG0488	(ABC) transporter
A2cp1_1795	COG2818	Glycosylase
A2cp1_1796	COG1252	NADH dehydrogenase
A2cp1_1800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A2cp1_1801	COG2204	response regulator
A2cp1_1802	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2cp1_1802	COG4191	Histidine kinase
A2cp1_1811	COG0785	Cytochrome C biogenesis protein
A2cp1_1814	COG2814	Major facilitator Superfamily
A2cp1_1815	COG0252	asparaginase activity
A2cp1_1817	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_1819	COG0559	Belongs to the binding-protein-dependent transport system permease family
A2cp1_1821	COG0410	ABC transporter
A2cp1_1824	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A2cp1_1826	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2cp1_1827	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A2cp1_1833	COG0515	serine threonine protein kinase
A2cp1_1836	COG1595	DNA-templated transcription, initiation
A2cp1_1837	COG0667	Aldo Keto reductase
A2cp1_1842	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A2cp1_1844	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A2cp1_1847	COG0686	Belongs to the AlaDH PNT family
A2cp1_1848	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A2cp1_1850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A2cp1_1853	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2cp1_1854	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2cp1_1854	COG4191	Histidine kinase
A2cp1_1855	COG2204	response regulator
A2cp1_1861	COG1053	succinate dehydrogenase
A2cp1_1863	COG0156	8-amino-7-oxononanoate synthase activity
A2cp1_1865	COG1201	RNA secondary structure unwinding
A2cp1_1866	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A2cp1_1867	COG2205	protein histidine kinase activity
A2cp1_1867	COG0784	Response regulator, receiver
A2cp1_1869	COG3064	Membrane
A2cp1_1869	COG0437	4 iron, 4 sulfur cluster binding
A2cp1_1870	COG3058	Necessary for formate dehydrogenase activity
A2cp1_1872	COG0626	cystathionine gamma-synthase activity
A2cp1_1877	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2cp1_1880	COG0667	Aldo Keto reductase
A2cp1_1885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2cp1_1886	COG0473	3-isopropylmalate dehydrogenase activity
A2cp1_1887	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A2cp1_1887	COG2755	lipolytic protein G-D-S-L family
A2cp1_1888	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A2cp1_1888	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A2cp1_1889	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A2cp1_1895	COG0488	(ABC) transporter
A2cp1_1898	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2cp1_1900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2cp1_1902	COG1164	Oligoendopeptidase f
A2cp1_1906	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A2cp1_1915	COG0351	phosphomethylpyrimidine kinase
A2cp1_1917	COG2095	MarC family integral membrane protein
A2cp1_1920	COG1136	(ABC) transporter
A2cp1_1921	COG0577	efflux transmembrane transporter activity
A2cp1_1921	COG1136	(ABC) transporter
A2cp1_1924	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A2cp1_1926	COG2373	Large extracellular alpha-helical protein
A2cp1_1927	COG4953	penicillin-binding protein 1C
A2cp1_1935	COG0656	L-ascorbic acid biosynthetic process
A2cp1_1941	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2cp1_1945	COG0501	Belongs to the peptidase M48B family
A2cp1_1946	COG0583	DNA-binding transcription factor activity
A2cp1_1949	COG0408	coproporphyrinogen oxidase activity
A2cp1_1951	COG0788	formyltetrahydrofolate deformylase activity
A2cp1_1952	COG5002	protein histidine kinase activity
A2cp1_1954	COG2204	response regulator
A2cp1_1956	COG3064	Membrane
A2cp1_1956	COG0437	4 iron, 4 sulfur cluster binding
A2cp1_1957	COG5557	Pfam Polysulphide reductase, NrfD
A2cp1_1958	COG0509	glycine decarboxylation via glycine cleavage system
A2cp1_1966	COG2197	response regulator
A2cp1_1969	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A2cp1_1970	COG4191	Histidine kinase
A2cp1_1972	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2cp1_1979	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2cp1_1982	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2cp1_1985	COG0028	Belongs to the TPP enzyme family
A2cp1_1991	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A2cp1_1992	COG0072	phenylalanine-tRNA ligase activity
A2cp1_1996	COG2146	nitrite reductase [NAD(P)H] activity
A2cp1_1997	COG0720	synthase
A2cp1_1998	COG0302	gtp cyclohydrolase
A2cp1_1999	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_2000	COG0277	FAD linked oxidase domain protein
A2cp1_2001	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2cp1_2001	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2cp1_2002	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2cp1_2004	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2cp1_2004	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2cp1_2005	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2cp1_2009	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2cp1_2011	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2cp1_2012	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A2cp1_2016	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2cp1_2017	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A2cp1_2026	COG0255	Belongs to the universal ribosomal protein uL29 family
A2cp1_2035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A2cp1_2038	COG0201	protein transport
A2cp1_2043	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A2cp1_2049	COG1837	Belongs to the UPF0109 family
A2cp1_2050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A2cp1_2054	COG0792	nuclease activity
A2cp1_2057	COG3852	Histidine kinase
A2cp1_2058	COG0741	lytic transglycosylase activity
A2cp1_2060	COG2894	cell division
A2cp1_2063	COG0564	pseudouridine synthase activity
A2cp1_2066	COG2226	methyltransferase
A2cp1_2068	COG1166	arginine decarboxylase activity
A2cp1_2072	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2cp1_2080	COG0564	pseudouridine synthase activity
A2cp1_2082	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A2cp1_2083	COG1127	ABC transporter
A2cp1_2085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2cp1_2087	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2cp1_2094	COG1024	Enoyl-CoA hydratase
A2cp1_2095	COG5002	protein histidine kinase activity
A2cp1_2098	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2cp1_2100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2cp1_2102	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A2cp1_2103	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A2cp1_2104	COG0022	dehydrogenase e1 component
A2cp1_2106	COG0084	hydrolase, TatD family'
A2cp1_2107	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A2cp1_2108	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2cp1_2111	COG1297	OPT oligopeptide transporter protein
A2cp1_2115	COG0527	aspartate kinase activity
A2cp1_2117	COG2183	response to ionizing radiation
A2cp1_2122	COG0210	DNA helicase
A2cp1_2123	COG0443	Heat shock 70 kDa protein
A2cp1_2150	COG2205	protein histidine kinase activity
A2cp1_2156	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A2cp1_2160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A2cp1_2161	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2cp1_2166	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A2cp1_2172	COG2197	response regulator
A2cp1_2175	COG4191	Histidine kinase
A2cp1_2175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2cp1_2176	COG2204	response regulator
A2cp1_2177	COG1027	Aspartate ammonia-lyase
A2cp1_2178	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A2cp1_2179	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A2cp1_2188	COG0024	Methionine aminopeptidase
A2cp1_2196	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A2cp1_2197	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A2cp1_2198	COG4208	sulfate ABC transporter
A2cp1_2200	COG0175	sulfate reduction
A2cp1_2201	COG2895	sulfate adenylyltransferase (ATP) activity
A2cp1_2202	COG0175	sulfate reduction
A2cp1_2204	COG0742	ribosomal rna small subunit methyltransferase
A2cp1_2208	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A2cp1_2210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A2cp1_2213	COG0436	Aminotransferase
A2cp1_2216	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A2cp1_2217	COG1058	Belongs to the CinA family
A2cp1_2217	COG1546	Belongs to the CinA family
A2cp1_2227	COG2204	response regulator
A2cp1_2229	COG0515	serine threonine protein kinase
A2cp1_2229	COG2815	serine threonine protein kinase
A2cp1_2231	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A2cp1_2242	COG1215	transferase activity, transferring glycosyl groups
A2cp1_2250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A2cp1_2254	COG0189	ligase activity
A2cp1_2257	COG0009	L-threonylcarbamoyladenylate synthase
A2cp1_2258	COG4974	Belongs to the 'phage' integrase family
A2cp1_2259	COG1994	Peptidase M50
A2cp1_2260	COG0180	Tryptophanyl-tRNA synthetase
A2cp1_2261	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A2cp1_2262	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A2cp1_2263	COG1187	pseudouridine synthase activity
A2cp1_2267	COG1595	DNA-templated transcription, initiation
A2cp1_2269	COG0430	RNA-3'-phosphate cyclase activity
A2cp1_2270	COG0598	Magnesium transport protein CorA
A2cp1_2272	COG0489	protein tyrosine kinase activity
A2cp1_2278	COG2205	protein histidine kinase activity
A2cp1_2279	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2cp1_2280	COG1024	Enoyl-CoA hydratase
A2cp1_2281	COG1960	acyl-CoA dehydrogenase activity
A2cp1_2282	COG1960	acyl-CoA dehydrogenase activity
A2cp1_2283	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2cp1_2283	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2cp1_2287	COG3005	denitrification pathway
A2cp1_2289	COG0494	nUDIX hydrolase
A2cp1_2292	COG1160	GTP binding
A2cp1_2293	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A2cp1_2296	COG0571	ribonuclease III activity
A2cp1_2297	COG1703	isobutyryl-CoA mutase activity
A2cp1_2299	COG1960	acyl-CoA dehydrogenase activity
A2cp1_2300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A2cp1_2301	COG1024	Enoyl-CoA hydratase
A2cp1_2308	COG1494	fructose-1,6-bisphosphatase
A2cp1_2317	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A2cp1_2318	COG1253	flavin adenine dinucleotide binding
A2cp1_2320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A2cp1_2322	COG0039	L-malate dehydrogenase activity
A2cp1_2323	COG0538	isocitrate dehydrogenase activity
A2cp1_2325	COG4191	Histidine kinase
A2cp1_2328	COG0505	Belongs to the CarA family
A2cp1_2331	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A2cp1_2333	COG0681	Belongs to the peptidase S26 family
A2cp1_2335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2cp1_2338	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A2cp1_2342	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2cp1_2343	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A2cp1_2344	COG4191	Histidine kinase
A2cp1_2353	COG0745	RESPONSE REGULATOR receiver
A2cp1_2367	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A2cp1_2368	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2cp1_2370	COG0189	ligase activity
A2cp1_2371	COG0443	Heat shock 70 kDa protein
A2cp1_2373	COG2921	Belongs to the UPF0250 family
A2cp1_2374	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A2cp1_2375	COG0745	RESPONSE REGULATOR receiver
A2cp1_2375	COG3706	GGDEF domain
A2cp1_2379	COG1309	transcriptional regulator
A2cp1_2384	COG1730	sister chromatid segregation
A2cp1_2397	COG0745	RESPONSE REGULATOR receiver
A2cp1_2397	COG3706	GGDEF domain
A2cp1_2398	COG2204	response regulator
A2cp1_2399	COG4191	Histidine kinase
A2cp1_2404	COG2766	serine protein kinase
A2cp1_2404	COG2766	serine protein kinase
A2cp1_2405	COG0443	Heat shock 70 kDa protein
A2cp1_2407	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A2cp1_2410	COG0101	tRNA pseudouridine synthase activity
A2cp1_2414	COG0529	Catalyzes the synthesis of activated sulfate
A2cp1_2417	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2cp1_2419	COG0443	Heat shock 70 kDa protein
A2cp1_2423	COG0149	triose-phosphate isomerase activity
A2cp1_2425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A2cp1_2427	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A2cp1_2434	COG0616	signal peptide processing
A2cp1_2435	COG2183	response to ionizing radiation
A2cp1_2435	COG0539	negative regulation of cytoplasmic translation
A2cp1_2439	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A2cp1_2441	COG0825	malonyl-CoA metabolic process
A2cp1_2447	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A2cp1_2452	COG0802	atpase or kinase
A2cp1_2453	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A2cp1_2453	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A2cp1_2455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A2cp1_2456	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2cp1_2458	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A2cp1_2459	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A2cp1_2460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2cp1_2461	COG0037	tRNA processing
A2cp1_2464	COG0004	ammonium transporteR
A2cp1_2467	COG0776	regulation of translation
A2cp1_2468	COG3246	L-lysine catabolic process to acetate
A2cp1_2469	COG1607	acyl-coa hydrolase
A2cp1_2470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2cp1_2472	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A2cp1_2473	COG0482	sulfurtransferase activity
A2cp1_2474	COG2205	protein histidine kinase activity
A2cp1_2475	COG0617	tRNA 3'-terminal CCA addition
A2cp1_2478	COG2204	response regulator
A2cp1_2483	COG2205	protein histidine kinase activity
A2cp1_2484	COG2205	protein histidine kinase activity
A2cp1_2485	COG0024	Methionine aminopeptidase
A2cp1_2489	COG0840	transmembrane signaling receptor activity
A2cp1_2493	COG2353	YceI-like domain
A2cp1_2494	COG0259	pyridoxamine-phosphate oxidase activity
A2cp1_2498	COG4191	Histidine kinase
A2cp1_2499	COG2204	response regulator
A2cp1_2500	COG0589	response to stress
A2cp1_2505	COG3387	PFAM Glycoside hydrolase 15-related
A2cp1_2506	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A2cp1_2507	COG0363	glucosamine-6-phosphate deaminase activity
A2cp1_2508	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A2cp1_2509	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A2cp1_2515	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A2cp1_2519	COG0343	queuine tRNA-ribosyltransferase activity
A2cp1_2520	COG0429	hydrolase of the alpha beta-hydrolase fold
A2cp1_2526	COG0038	chloride channel
A2cp1_2539	COG3436	PFAM IS66 Orf2 family protein
A2cp1_2543	COG2801	Transposase and inactivated derivatives
A2cp1_2545	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A2cp1_2546	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A2cp1_2547	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2cp1_2552	COG3604	Transcriptional regulator
A2cp1_2557	COG1558	bacterial-type flagellum-dependent cell motility
A2cp1_2558	COG1677	Flagellar hook-basal body complex protein FliE
A2cp1_2560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A2cp1_2568	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A2cp1_2569	COG1360	Flagellar Motor Protein
A2cp1_2570	COG2201	protein-glutamate methylesterase activity
A2cp1_2571	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A2cp1_2572	COG0835	chemotaxis
A2cp1_2573	COG0840	transmembrane signaling receptor activity
A2cp1_2574	COG0643	Histidine kinase
A2cp1_2574	COG2198	Histidine kinase
A2cp1_2575	COG0745	RESPONSE REGULATOR receiver
A2cp1_2578	COG0835	chemotaxis
A2cp1_2579	COG0840	transmembrane signaling receptor activity
A2cp1_2580	COG2201	protein-glutamate methylesterase activity
A2cp1_2581	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A2cp1_2586	COG1639	'signal transduction protein
A2cp1_2591	COG1338	Plays a role in the flagellum-specific transport system
A2cp1_2592	COG1987	bacterial-type flagellum assembly
A2cp1_2593	COG1684	flagellar biosynthetic protein fliR
A2cp1_2594	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A2cp1_2595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A2cp1_2597	COG0455	bacterial-type flagellum organization
A2cp1_2601	COG4786	Flagellar basal body rod
A2cp1_2602	COG4786	Flagellar basal body rod
A2cp1_2606	COG0739	heme binding
A2cp1_2611	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A2cp1_2612	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A2cp1_2615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A2cp1_2617	COG0463	Glycosyl transferase, family 2
A2cp1_2617	COG0457	Tetratricopeptide repeat
A2cp1_2620	COG1763	Mo-molybdopterin cofactor biosynthetic process
A2cp1_2621	COG0303	'Molybdopterin
A2cp1_2623	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2cp1_2625	COG2239	Acts as a magnesium transporter
A2cp1_2626	COG2205	protein histidine kinase activity
A2cp1_2627	COG0745	RESPONSE REGULATOR receiver
A2cp1_2627	COG4566	intracellular signal transduction
A2cp1_2628	COG5002	protein histidine kinase activity
A2cp1_2629	COG2204	response regulator
A2cp1_2630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2cp1_2638	COG1335	isochorismatase
A2cp1_2639	COG3481	metal-dependent phosphohydrolase, HD sub domain
A2cp1_2641	COG0084	hydrolase, TatD family'
A2cp1_2642	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2cp1_2642	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2cp1_2645	COG3599	regulation of cell shape
A2cp1_2658	COG0602	queuosine metabolic process
A2cp1_2659	COG0741	lytic transglycosylase activity
A2cp1_2667	COG2937	Belongs to the GPAT DAPAT family
A2cp1_2669	COG0483	inositol monophosphate 1-phosphatase activity
A2cp1_2671	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2cp1_2672	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2cp1_2676	COG1045	serine acetyltransferase
A2cp1_2679	COG0556	nucleotide-excision repair
A2cp1_2681	COG1278	Cold shock
A2cp1_2684	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A2cp1_2684	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A2cp1_2686	COG0658	competence protein
A2cp1_2686	COG2333	competence protein COMEC
A2cp1_2694	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2cp1_2695	COG1309	transcriptional regulator
A2cp1_2696	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A2cp1_2699	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A2cp1_2700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A2cp1_2703	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A2cp1_2706	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A2cp1_2709	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A2cp1_2712	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A2cp1_2714	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2cp1_2717	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2cp1_2721	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2cp1_2723	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A2cp1_2724	COG1278	Cold shock
A2cp1_2728	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A2cp1_2729	COG2766	serine protein kinase
A2cp1_2730	COG2718	Belongs to the UPF0229 family
A2cp1_2731	COG2719	SpoVR family
A2cp1_2735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2cp1_2740	COG1047	Peptidyl-prolyl cis-trans
A2cp1_2742	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A2cp1_2743	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_2744	COG3411	Ferredoxin
A2cp1_2748	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A2cp1_2756	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A2cp1_2759	COG5002	protein histidine kinase activity
A2cp1_2768	COG1269	ATP hydrolysis coupled proton transport
A2cp1_2774	COG2201	protein-glutamate methylesterase activity
A2cp1_2775	COG2205	protein histidine kinase activity
A2cp1_2777	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2cp1_2781	COG1309	transcriptional regulator
A2cp1_2785	COG1573	uracil-dna glycosylase
A2cp1_2786	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A2cp1_2787	COG0194	GDP metabolic process
A2cp1_2788	COG1561	YicC-like family, N-terminal region
A2cp1_2789	COG2835	tetraacyldisaccharide 4'-kinase activity
A2cp1_2791	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A2cp1_2791	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2cp1_2793	COG1560	Kdo2-lipid A biosynthetic process
A2cp1_2795	COG0859	PFAM glycosyl transferase family 9
A2cp1_2796	COG1519	Transferase
A2cp1_2798	COG1132	(ABC) transporter
A2cp1_2799	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2cp1_2800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2cp1_2803	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A2cp1_2804	COG2095	MarC family integral membrane protein
A2cp1_2805	COG1216	Glycosyl transferase, family 2
A2cp1_2812	COG0437	4 iron, 4 sulfur cluster binding
A2cp1_2813	COG0243	molybdopterin cofactor binding
A2cp1_2816	COG0745	RESPONSE REGULATOR receiver
A2cp1_2818	COG1053	succinate dehydrogenase
A2cp1_2820	COG0438	transferase activity, transferring glycosyl groups
A2cp1_2827	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A2cp1_2828	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2cp1_2830	COG0489	protein tyrosine kinase activity
A2cp1_2835	COG2204	response regulator
A2cp1_2839	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A2cp1_2841	COG1136	(ABC) transporter
A2cp1_2852	COG0492	ferredoxin-NADP+ reductase activity
A2cp1_2858	COG2169	Transcriptional regulator
A2cp1_2862	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A2cp1_2863	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A2cp1_2870	COG0237	dephospho-CoA kinase activity
A2cp1_2875	COG0443	Heat shock 70 kDa protein
A2cp1_2877	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A2cp1_2878	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2cp1_2879	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A2cp1_2885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2cp1_2887	COG1652	LysM domain
A2cp1_2890	COG2203	Gaf domain
A2cp1_2890	COG3706	GGDEF domain
A2cp1_2890	COG5001	Diguanylate cyclase
A2cp1_2890	COG4251	negative regulation of phosphorylation
A2cp1_2891	COG1196	nuclear chromosome segregation
A2cp1_2891	COG0745	RESPONSE REGULATOR receiver
A2cp1_2893	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A2cp1_2896	COG0438	transferase activity, transferring glycosyl groups
A2cp1_2898	COG4932	domain protein
A2cp1_2898	COG5492	domain, Protein
A2cp1_2901	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A2cp1_2902	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A2cp1_2904	COG1480	7TM receptor with intracellular HD hydrolase
A2cp1_2906	COG0457	Tetratricopeptide repeat
A2cp1_2908	COG3956	TIGRFAM MazG family protein
A2cp1_2911	COG0495	leucyl-tRNA aminoacylation
A2cp1_2912	COG0017	Asparaginyl-tRNA synthetase
A2cp1_2914	COG2201	protein-glutamate methylesterase activity
A2cp1_2915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A2cp1_2917	COG0835	chemotaxis
A2cp1_2919	COG3409	Peptidoglycan-binding domain 1 protein
A2cp1_2919	COG3267	Type II secretory pathway component ExeA
A2cp1_2920	COG2198	Histidine kinase
A2cp1_2920	COG0643	Histidine kinase
A2cp1_2924	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2cp1_2924	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2cp1_2926	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2cp1_2926	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2cp1_2929	COG0698	ribose 5-phosphate isomerase
A2cp1_2931	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2cp1_2933	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A2cp1_2934	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A2cp1_2936	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A2cp1_2943	COG2827	Endonuclease containing a URI domain
A2cp1_2944	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_2949	COG0438	transferase activity, transferring glycosyl groups
A2cp1_2950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2cp1_2953	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A2cp1_2956	COG0367	asparagine synthase
A2cp1_2957	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A2cp1_2958	COG0318	PFAM AMP-dependent synthetase and ligase
A2cp1_2971	COG0438	transferase activity, transferring glycosyl groups
A2cp1_2972	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A2cp1_2977	COG0493	'glutamate synthase
A2cp1_2977	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A2cp1_2983	COG0515	serine threonine protein kinase
A2cp1_2983	COG2815	serine threonine protein kinase
A2cp1_2986	COG3186	Phenylalanine-4-hydroxylase
A2cp1_2987	COG0488	(ABC) transporter
A2cp1_2991	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2cp1_2991	COG0784	Response regulator, receiver
A2cp1_2991	COG2198	Histidine kinase
A2cp1_2991	COG2205	protein histidine kinase activity
A2cp1_3000	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_3007	COG4964	Belongs to the GSP D family
A2cp1_3027	COG0604	alcohol dehydrogenase
A2cp1_3032	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2cp1_3034	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2cp1_3042	COG1301	dicarboxylic acid transport
A2cp1_3045	COG0247	lactate metabolic process
A2cp1_3046	COG0277	FAD linked oxidase domain protein
A2cp1_3047	COG0277	FAD linked oxidase domain protein
A2cp1_3063	COG1309	transcriptional regulator
A2cp1_3070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A2cp1_3076	COG2226	methyltransferase
A2cp1_3082	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A2cp1_3084	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A2cp1_3085	COG0406	alpha-ribazole phosphatase activity
A2cp1_3088	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A2cp1_3089	COG0702	epimerase
A2cp1_3092	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A2cp1_3094	COG0318	PFAM AMP-dependent synthetase and ligase
A2cp1_3095	COG0671	phosphoesterase, PA-phosphatase related
A2cp1_3103	COG1376	ErfK ybiS ycfS ynhG family protein
A2cp1_3103	COG1388	LysM domain
A2cp1_3106	COG0745	RESPONSE REGULATOR receiver
A2cp1_3107	COG2205	protein histidine kinase activity
A2cp1_3117	COG1215	transferase activity, transferring glycosyl groups
A2cp1_3118	COG1649	PFAM Uncharacterised BCR, COG1649
A2cp1_3118	COG0726	polysaccharide deacetylase
A2cp1_3120	COG4968	Prepilin-type N-terminal cleavage methylation domain
A2cp1_3126	COG1053	succinate dehydrogenase
A2cp1_3130	COG1404	Belongs to the peptidase S8 family
A2cp1_3130	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A2cp1_3135	COG2205	protein histidine kinase activity
A2cp1_3135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2cp1_3136	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A2cp1_3137	COG2205	protein histidine kinase activity
A2cp1_3138	COG0745	RESPONSE REGULATOR receiver
A2cp1_3149	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A2cp1_3150	COG0513	Belongs to the DEAD box helicase family
A2cp1_3151	COG0784	Response regulator, receiver
A2cp1_3151	COG2205	protein histidine kinase activity
A2cp1_3154	COG2271	Major facilitator Superfamily
A2cp1_3156	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2cp1_3158	COG0574	Belongs to the PEP-utilizing enzyme family
A2cp1_3158	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2cp1_3159	COG0484	heat shock protein binding
A2cp1_3166	COG1136	(ABC) transporter
A2cp1_3166	COG0577	efflux transmembrane transporter activity
A2cp1_3167	COG4591	ABC-type transport system involved in lipoprotein release permease component
A2cp1_3167	COG1136	(ABC) transporter
A2cp1_3168	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2cp1_3169	COG3275	phosphorelay sensor kinase activity
A2cp1_3170	COG3279	Response regulator of the LytR AlgR family
A2cp1_3172	COG1620	l-lactate permease
A2cp1_3174	COG1139	Iron-sulfur cluster binding protein
A2cp1_3177	COG4106	trans-aconitate 2-methyltransferase activity
A2cp1_3181	COG2264	protein methyltransferase activity
A2cp1_3187	COG2860	membrane
A2cp1_3193	COG4106	trans-aconitate 2-methyltransferase activity
A2cp1_3194	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2cp1_3195	COG0745	RESPONSE REGULATOR receiver
A2cp1_3197	COG1396	sequence-specific DNA binding
A2cp1_3197	COG3800	Transcriptional regulator
A2cp1_3198	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A2cp1_3202	COG0366	Alpha amylase catalytic
A2cp1_3205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A2cp1_3206	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A2cp1_3207	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A2cp1_3209	COG0318	PFAM AMP-dependent synthetase and ligase
A2cp1_3212	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2cp1_3213	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2cp1_3213	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2cp1_3215	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A2cp1_3217	COG2703	oxygen carrier activity
A2cp1_3218	COG0277	FAD linked oxidase domain protein
A2cp1_3219	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A2cp1_3222	COG1960	acyl-CoA dehydrogenase activity
A2cp1_3225	COG0702	epimerase
A2cp1_3227	COG3272	Protein of unknown function (DUF1722)
A2cp1_3229	COG1295	ribonuclease BN
A2cp1_3231	COG0443	Heat shock 70 kDa protein
A2cp1_3232	COG0443	Heat shock 70 kDa protein
A2cp1_3235	COG0667	Aldo Keto reductase
A2cp1_3236	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2cp1_3239	COG0667	Aldo Keto reductase
A2cp1_3240	COG0693	protein deglycase activity
A2cp1_3243	COG0513	Belongs to the DEAD box helicase family
A2cp1_3248	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A2cp1_3249	COG1216	Glycosyl transferase, family 2
A2cp1_3250	COG1216	Glycosyl transferase, family 2
A2cp1_3277	COG0840	transmembrane signaling receptor activity
A2cp1_3278	COG0137	argininosuccinate synthase activity
A2cp1_3285	COG2204	response regulator
A2cp1_3289	COG1733	regulation of RNA biosynthetic process
A2cp1_3290	COG0702	epimerase
A2cp1_3291	COG0667	Aldo Keto reductase
A2cp1_3295	COG2267	carboxylic ester hydrolase activity
A2cp1_3299	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A2cp1_3299	COG3608	succinylglutamate desuccinylase aspartoacylase
A2cp1_3300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A2cp1_3302	COG0339	signal peptide processing
A2cp1_3303	COG3852	Histidine kinase
A2cp1_3305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2cp1_3306	COG1131	(ABC) transporter
A2cp1_3307	COG1131	(ABC) transporter
A2cp1_3308	COG0842	Transport permease protein
A2cp1_3309	COG0842	Transport permease protein
A2cp1_3310	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A2cp1_3311	COG2329	Antibiotic biosynthesis monooxygenase
A2cp1_3312	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2cp1_3312	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2cp1_3314	COG3842	ATPase activity
A2cp1_3319	COG3795	YCII-related domain
A2cp1_3323	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A2cp1_3324	COG1595	DNA-templated transcription, initiation
A2cp1_3325	COG0583	DNA-binding transcription factor activity
A2cp1_3327	COG1162	GTPase activity
A2cp1_3328	COG0784	Response regulator, receiver
A2cp1_3328	COG2205	protein histidine kinase activity
A2cp1_3330	COG1309	transcriptional regulator
A2cp1_3331	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_3337	COG0723	plastoquinol--plastocyanin reductase activity
A2cp1_3343	COG2855	membrane
A2cp1_3357	COG1064	alcohol dehydrogenase
A2cp1_3360	COG1131	(ABC) transporter
A2cp1_3361	COG0025	NhaP-type Na H and K H
A2cp1_3364	COG1473	amidohydrolase
A2cp1_3366	COG1278	Cold shock
A2cp1_3368	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2cp1_3368	COG0596	Alpha beta hydrolase
A2cp1_3372	COG0517	IMP dehydrogenase activity
A2cp1_3372	COG1125	glycine betaine transport
A2cp1_3373	COG1174	glycine betaine transport
A2cp1_3375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A2cp1_3376	COG0784	Response regulator, receiver
A2cp1_3376	COG2205	protein histidine kinase activity
A2cp1_3379	COG3459	Glycosyltransferase 36 associated
A2cp1_3380	COG3239	Fatty acid desaturase
A2cp1_3389	COG2130	NADP-dependent
A2cp1_3391	COG3387	PFAM Glycoside hydrolase 15-related
A2cp1_3392	COG1993	acr, cog1993
A2cp1_3397	COG2207	Transcriptional regulator
A2cp1_3403	COG1595	DNA-templated transcription, initiation
A2cp1_3406	COG0006	proline dipeptidase activity
A2cp1_3412	COG1918	ferrous iron import across plasma membrane
A2cp1_3412	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A2cp1_3414	COG0604	alcohol dehydrogenase
A2cp1_3439	COG0516	GMP reductase activity
A2cp1_3440	COG2132	Multicopper oxidase
A2cp1_3442	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A2cp1_3447	COG1704	LemA family
A2cp1_3448	COG0501	Belongs to the peptidase M48B family
A2cp1_3450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A2cp1_3457	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A2cp1_3461	COG5337	Spore coat protein CotH
A2cp1_3476	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A2cp1_3483	COG2204	response regulator
A2cp1_3487	COG5000	phosphorelay sensor kinase activity
A2cp1_3490	COG2252	PERMEase
A2cp1_3491	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A2cp1_3493	COG2136	Putative SAM-dependent methyltransferase
A2cp1_3493	COG2521	methyltransferase
A2cp1_3497	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2cp1_3497	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2cp1_3500	COG0544	peptidyl-prolyl cis-trans isomerase activity
A2cp1_3502	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A2cp1_3504	COG0463	Glycosyl transferase, family 2
A2cp1_3506	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A2cp1_3512	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A2cp1_3516	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2cp1_3518	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A2cp1_3520	COG0210	DNA helicase
A2cp1_3526	COG0564	pseudouridine synthase activity
A2cp1_3527	COG0625	glutathione transferase activity
A2cp1_3528	COG0612	Peptidase, M16
A2cp1_3530	COG4191	Histidine kinase
A2cp1_3532	COG1129	ABC transporter
A2cp1_3533	COG0739	heme binding
A2cp1_3534	COG0483	inositol monophosphate 1-phosphatase activity
A2cp1_3537	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2cp1_3540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A2cp1_3542	COG1619	proteins homologs of microcin C7 resistance protein MccF
A2cp1_3543	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2cp1_3544	COG0628	permease
A2cp1_3545	COG0545	Peptidyl-prolyl cis-trans isomerase
A2cp1_3558	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A2cp1_3559	COG1136	(ABC) transporter
A2cp1_3560	COG4591	ABC-type transport system involved in lipoprotein release permease component
A2cp1_3561	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2cp1_3563	COG0189	ligase activity
A2cp1_3567	COG4106	trans-aconitate 2-methyltransferase activity
A2cp1_3571	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A2cp1_3576	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A2cp1_3577	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A2cp1_3578	COG1846	Transcriptional regulator
A2cp1_3582	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A2cp1_3584	COG0471	metal ion transport
A2cp1_3584	COG3273	potassium ion transport
A2cp1_3588	COG0123	including yeast histone deacetylase and acetoin utilization protein
A2cp1_3590	COG3123	guanosine phosphorylase activity
A2cp1_3593	COG0587	DNA-directed DNA polymerase activity
A2cp1_3594	COG0730	response to heat
A2cp1_3596	COG2197	response regulator
A2cp1_3597	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A2cp1_3606	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A2cp1_3608	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A2cp1_3613	COG4206	TonB-dependent receptor
A2cp1_3615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2cp1_3616	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2cp1_3617	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A2cp1_3620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A2cp1_3621	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2cp1_3624	COG3852	Histidine kinase
A2cp1_3625	COG3706	GGDEF domain
A2cp1_3625	COG0745	RESPONSE REGULATOR receiver
A2cp1_3628	COG2096	Adenosyltransferase
A2cp1_3630	COG0316	Belongs to the HesB IscA family
A2cp1_3631	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2cp1_3632	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A2cp1_3634	COG0746	molybdenum cofactor guanylyltransferase activity
A2cp1_3639	COG4106	trans-aconitate 2-methyltransferase activity
A2cp1_3640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A2cp1_3641	COG1741	Belongs to the pirin family
A2cp1_3648	COG1937	Protein conserved in bacteria
A2cp1_3652	COG1937	Protein conserved in bacteria
A2cp1_3653	COG2217	Heavy metal translocating P-type atpase
A2cp1_3656	COG4941	Belongs to the sigma-70 factor family
A2cp1_3657	COG3795	YCII-related domain
A2cp1_3661	COG0438	transferase activity, transferring glycosyl groups
A2cp1_3663	COG0667	Aldo Keto reductase
A2cp1_3664	COG0583	DNA-binding transcription factor activity
A2cp1_3665	COG3118	belongs to the thioredoxin family
A2cp1_3671	COG0840	transmembrane signaling receptor activity
A2cp1_3672	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A2cp1_3674	COG0745	RESPONSE REGULATOR receiver
A2cp1_3679	COG0330	HflC and HflK could
A2cp1_3684	COG1053	succinate dehydrogenase
A2cp1_3684	COG3976	FMN-binding domain protein
A2cp1_3701	COG4974	Belongs to the 'phage' integrase family
A2cp1_3705	COG0739	heme binding
A2cp1_3705	COG0741	lytic transglycosylase activity
A2cp1_3705	COG1196	nuclear chromosome segregation
A2cp1_3706	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A2cp1_3708	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A2cp1_3712	COG2267	carboxylic ester hydrolase activity
A2cp1_3715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A2cp1_3718	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A2cp1_3719	COG1090	epimerase
A2cp1_3722	COG0750	zinc metalloprotease
A2cp1_3724	COG4589	Belongs to the CDS family
A2cp1_3725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A2cp1_3734	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A2cp1_3735	COG0459	protein refolding
A2cp1_3745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A2cp1_3749	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A2cp1_3750	COG1183	phosphatidylcholine synthase activity
A2cp1_3751	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A2cp1_3774	COG1100	Small GTP-binding protein
A2cp1_3776	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A2cp1_3778	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A2cp1_3779	COG0590	tRNA wobble adenosine to inosine editing
A2cp1_3782	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2cp1_3782	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2cp1_3787	COG2261	transglycosylase associated protein
A2cp1_3795	COG0651	ATP synthesis coupled electron transport
A2cp1_3796	COG0651	ATP synthesis coupled electron transport
A2cp1_3799	COG0651	ATP synthesis coupled electron transport
A2cp1_3800	COG0649	NAD binding
A2cp1_3801	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2cp1_3805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A2cp1_3806	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A2cp1_3809	COG0475	glutathione-regulated potassium exporter activity
A2cp1_3812	COG0739	heme binding
A2cp1_3814	COG0539	negative regulation of cytoplasmic translation
A2cp1_3822	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A2cp1_3824	COG1428	Deoxynucleoside kinase
A2cp1_3829	COG0745	RESPONSE REGULATOR receiver
A2cp1_3829	COG3706	GGDEF domain
A2cp1_3830	COG0484	heat shock protein binding
A2cp1_3832	COG0631	protein serine/threonine phosphatase activity
A2cp1_3833	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A2cp1_3837	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2cp1_3839	COG0477	Major facilitator Superfamily
A2cp1_3843	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2cp1_3844	COG0840	transmembrane signaling receptor activity
A2cp1_3847	COG0626	cystathionine gamma-synthase activity
A2cp1_3850	COG0477	Major facilitator Superfamily
A2cp1_3858	COG0840	transmembrane signaling receptor activity
A2cp1_3859	COG1902	pentaerythritol trinitrate reductase activity
A2cp1_3861	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2cp1_3862	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2cp1_3864	COG3850	Histidine kinase
A2cp1_3864	COG5002	protein histidine kinase activity
A2cp1_3867	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A2cp1_3869	COG3852	Histidine kinase
A2cp1_3870	COG2204	response regulator
A2cp1_3871	COG1271	oxidase subunit
A2cp1_3872	COG1294	oxidase, subunit
A2cp1_3874	COG2226	methyltransferase
A2cp1_3881	COG0515	serine threonine protein kinase
A2cp1_3883	COG1024	Enoyl-CoA hydratase
A2cp1_3884	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A2cp1_3887	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_3889	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A2cp1_3891	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A2cp1_3895	COG0437	4 iron, 4 sulfur cluster binding
A2cp1_3896	COG2864	formate dehydrogenase
A2cp1_3900	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_3906	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A2cp1_3907	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A2cp1_3909	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2cp1_3918	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A2cp1_3921	COG0640	Transcriptional regulator
A2cp1_3925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A2cp1_3928	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A2cp1_3930	COG1136	(ABC) transporter
A2cp1_3930	COG0577	efflux transmembrane transporter activity
A2cp1_3932	COG1388	LysM domain
A2cp1_3932	COG1705	Flagellar rod assembly protein muramidase FlgJ
A2cp1_3934	COG2204	response regulator
A2cp1_3939	COG0793	Belongs to the peptidase S41A family
A2cp1_3942	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A2cp1_3948	COG0673	inositol 2-dehydrogenase activity
A2cp1_3950	COG2027	D-alanyl-D-alanine carboxypeptidase
A2cp1_3951	COG0629	single-stranded DNA binding
A2cp1_3956	COG0640	Transcriptional regulator
A2cp1_3960	COG1309	transcriptional regulator
A2cp1_3965	COG2003	Belongs to the UPF0758 family
A2cp1_3967	COG2353	YceI-like domain
A2cp1_3969	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2cp1_3976	COG1192	Involved in chromosome partitioning
A2cp1_3981	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2cp1_3982	COG0047	phosphoribosylformylglycinamidine synthase activity
A2cp1_3986	COG0312	modulator of DNA gyrase
A2cp1_3987	COG0312	modulator of DNA gyrase
A2cp1_3990	COG4221	oxidoreductase activity
A2cp1_3996	COG2205	protein histidine kinase activity
A2cp1_3997	COG0745	RESPONSE REGULATOR receiver
A2cp1_4005	COG2801	Transposase and inactivated derivatives
A2cp1_4011	COG1061	Type III restriction enzyme res subunit
A2cp1_4018	COG1595	DNA-templated transcription, initiation
A2cp1_4019	COG1201	RNA secondary structure unwinding
A2cp1_4021	COG1074	ATP-dependent DNA helicase activity
A2cp1_4023	COG0653	protein targeting
A2cp1_4030	COG1032	radical SAM domain protein
A2cp1_4036	COG0745	RESPONSE REGULATOR receiver
A2cp1_4039	COG0840	transmembrane signaling receptor activity
A2cp1_4041	COG0604	alcohol dehydrogenase
A2cp1_4041	COG1028	Short-chain dehydrogenase reductase Sdr
A2cp1_4041	COG3321	synthase
A2cp1_4042	COG0604	alcohol dehydrogenase
A2cp1_4042	COG3321	synthase
A2cp1_4044	COG2378	regulation of single-species biofilm formation
A2cp1_4048	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A2cp1_4051	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A2cp1_4057	COG0488	(ABC) transporter
A2cp1_4064	COG1322	Protein conserved in bacteria
A2cp1_4068	COG0154	amidase activity
A2cp1_4070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A2cp1_4071	COG0280	phosphate acetyltransferase
A2cp1_4071	COG0281	malic enzyme
A2cp1_4075	COG1252	NADH dehydrogenase
A2cp1_4081	COG1136	(ABC) transporter
A2cp1_4083	COG2840	Smr protein MutS2
A2cp1_4086	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2cp1_4087	COG2239	Acts as a magnesium transporter
A2cp1_4092	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A2cp1_4093	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2cp1_4093	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2cp1_4094	COG0492	ferredoxin-NADP+ reductase activity
A2cp1_4095	COG0315	cyclic pyranopterin monophosphate synthase activity
A2cp1_4100	COG0405	Gamma-glutamyltransferase
A2cp1_4102	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A2cp1_4103	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A2cp1_4112	COG2379	hydroxypyruvate reductase
A2cp1_4115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A2cp1_4116	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A2cp1_4119	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A2cp1_4126	COG0670	Belongs to the BI1 family
A2cp1_4128	COG0584	glycerophosphoryl diester phosphodiesterase
A2cp1_4130	COG0488	(ABC) transporter
A2cp1_4131	COG2814	Major facilitator Superfamily
A2cp1_4141	COG3647	Membrane
A2cp1_4144	COG0704	Plays a role in the regulation of phosphate uptake
A2cp1_4145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A2cp1_4146	COG0581	inorganic phosphate transmembrane transporter activity
A2cp1_4147	COG0573	inorganic phosphate transmembrane transporter activity
A2cp1_4148	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A2cp1_4150	COG5002	protein histidine kinase activity
A2cp1_4154	COG0116	Belongs to the methyltransferase superfamily
A2cp1_4154	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2cp1_4159	COG2814	Major facilitator Superfamily
A2cp1_4163	COG3104	oligopeptide transport
A2cp1_4164	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A2cp1_4165	COG2363	Small membrane protein
A2cp1_4166	COG2154	pterin-4-alpha-carbinolamine dehydratase
A2cp1_4168	COG1408	metallophosphoesterase
A2cp1_4177	COG0811	peptide transport
A2cp1_4181	COG2030	dehydratase
A2cp1_4183	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2cp1_4186	COG0768	penicillin binding
A2cp1_4187	COG0574	Belongs to the PEP-utilizing enzyme family
A2cp1_4187	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2cp1_4189	COG0425	Belongs to the sulfur carrier protein TusA family
A2cp1_4192	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2cp1_4192	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2cp1_4195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2cp1_4198	COG0134	indole-3-glycerol-phosphate synthase activity
A2cp1_4199	COG0135	phosphoribosylanthranilate isomerase activity
A2cp1_4200	COG0133	tryptophan synthase activity
A2cp1_4201	COG0159	tryptophan synthase activity
A2cp1_4203	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A2cp1_4209	COG1846	Transcriptional regulator
A2cp1_4210	COG0697	spore germination
A2cp1_4212	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A2cp1_4212	COG0517	IMP dehydrogenase activity
A2cp1_4214	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A2cp1_4215	COG0179	Fumarylacetoacetate (FAA) hydrolase
A2cp1_4218	COG0019	diaminopimelate decarboxylase activity
A2cp1_4223	COG0346	lactoylglutathione lyase activity
A2cp1_4225	COG2715	membrane protein required for spore maturation
A2cp1_4226	COG0700	Nucleoside recognition
A2cp1_4235	COG0297	glycogen (starch) synthase activity
A2cp1_4245	COG0438	transferase activity, transferring glycosyl groups
A2cp1_4247	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A2cp1_4249	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A2cp1_4253	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2cp1_4255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2cp1_4269	COG2198	Histidine kinase
A2cp1_4269	COG2205	protein histidine kinase activity
A2cp1_4269	COG0784	Response regulator, receiver
A2cp1_4272	COG1960	acyl-CoA dehydrogenase activity
A2cp1_4275	COG2198	Histidine kinase
A2cp1_4275	COG0784	Response regulator, receiver
A2cp1_4275	COG2205	protein histidine kinase activity
A2cp1_4276	COG0784	Response regulator, receiver
A2cp1_4276	COG2198	Histidine kinase
A2cp1_4276	COG5002	protein histidine kinase activity
A2cp1_4287	COG0395	ABC-type sugar transport system, permease component
A2cp1_4288	COG1175	transmembrane transport
A2cp1_4290	COG3842	ATPase activity
A2cp1_4291	COG0366	Alpha amylase catalytic
A2cp1_4300	COG0438	transferase activity, transferring glycosyl groups
A2cp1_4307	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2cp1_4308	COG1136	(ABC) transporter
A2cp1_4308	COG0577	efflux transmembrane transporter activity
A2cp1_4309	COG0577	efflux transmembrane transporter activity
A2cp1_4309	COG1136	(ABC) transporter
A2cp1_4310	COG1136	(ABC) transporter
A2cp1_4310	COG0577	efflux transmembrane transporter activity
A2cp1_4311	COG0681	Belongs to the peptidase S26 family
A2cp1_4314	COG3259	Nickel-dependent hydrogenase
A2cp1_4318	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2cp1_4324	COG1560	Kdo2-lipid A biosynthetic process
A2cp1_4325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A2cp1_4326	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A2cp1_4332	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2cp1_4337	COG3339	Conserved Protein
A2cp1_4345	COG0457	Tetratricopeptide repeat
A2cp1_4346	COG1674	ftsk spoiiie
A2cp1_4347	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A2cp1_4347	COG2885	chlorophyll binding
A2cp1_4353	COG0839	Belongs to the complex I subunit 6 family
A2cp1_4356	COG0784	Response regulator, receiver
A2cp1_4356	COG0835	chemotaxis
A2cp1_4357	COG2153	protein acetylation
A2cp1_4361	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A2cp1_4368	COG2205	protein histidine kinase activity
A2cp1_4368	COG0784	Response regulator, receiver
A2cp1_4375	COG1193	negative regulation of DNA recombination
A2cp1_4376	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A2cp1_4382	COG5002	protein histidine kinase activity
A2cp1_4384	COG0306	phosphate transporter
A2cp1_4385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A2cp1_4392	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2cp1_4398	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2cp1_4402	COG3852	Histidine kinase
A2cp1_4406	COG2204	response regulator
A2cp1_4408	COG0174	glutamine synthetase
A2cp1_4409	COG2076	Multidrug Resistance protein
A2cp1_4413	COG0411	ABC transporter
A2cp1_4415	COG0559	Belongs to the binding-protein-dependent transport system permease family
A2cp1_4417	COG0745	RESPONSE REGULATOR receiver
A2cp1_4420	COG1472	Belongs to the glycosyl hydrolase 3 family
A2cp1_4423	COG0714	Associated with various cellular activities
A2cp1_4429	COG3206	protein involved in exopolysaccharide biosynthesis
A2cp1_4429	COG0489	protein tyrosine kinase activity
A2cp1_4430	COG1596	polysaccharide export
A2cp1_4434	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2cp1_4438	COG0438	transferase activity, transferring glycosyl groups
A2cp1_4439	COG0438	transferase activity, transferring glycosyl groups
A2cp1_4447	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2cp1_4448	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A2cp1_4453	COG0463	Glycosyl transferase, family 2
A2cp1_4456	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2cp1_4461	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A2cp1_4462	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A2cp1_4467	COG3852	Histidine kinase
A2cp1_4468	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A2cp1_4469	COG1691	(AIR) carboxylase
A2cp1_4471	COG2198	Histidine kinase
A2cp1_4471	COG0643	Histidine kinase
A2cp1_4472	COG2201	protein-glutamate methylesterase activity
A2cp1_4474	COG0840	transmembrane signaling receptor activity
A2cp1_4474	COG3290	protein histidine kinase activity
A2cp1_4475	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A2cp1_4476	COG2205	protein histidine kinase activity
A2cp1_4476	COG2202	Pas domain
A2cp1_4477	COG1100	Small GTP-binding protein
A2cp1_4478	COG1199	ATP-dependent helicase activity
A2cp1_4482	COG0484	heat shock protein binding
A2cp1_4483	COG0443	Heat shock 70 kDa protein
A2cp1_4484	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A2cp1_4489	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2cp1_4490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2cp1_4491	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A2cp1_4492	COG0012	GTP binding
A2cp1_4494	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2cp1_4503	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A2cp1_4507	COG0071	Belongs to the small heat shock protein (HSP20) family
A2cp1_4509	COG1475	DNA binding
A2cp1_4510	COG1192	Involved in chromosome partitioning
A2cp1_4516	COG0594	ribonuclease P activity