locus-tag	class	description
Adeh_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Adeh_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Adeh_0005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Adeh_0008	COG0247	lactate metabolic process
Adeh_0008	COG2181	nitrate reductase activity
Adeh_0011	COG0189	ligase activity
Adeh_0012	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Adeh_0013	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Adeh_0014	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Adeh_0021	COG3852	Histidine kinase
Adeh_0024	COG0442	prolyl-tRNA aminoacylation
Adeh_0031	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_0034	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Adeh_0036	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Adeh_0038	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Adeh_0041	COG0280	phosphate acetyltransferase
Adeh_0042	COG3426	butyrate kinase activity
Adeh_0048	COG2086	electron transfer activity
Adeh_0050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Adeh_0051	COG0861	Integral membrane protein TerC family
Adeh_0055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Adeh_0055	COG1793	dna ligase
Adeh_0056	COG0564	pseudouridine synthase activity
Adeh_0060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Adeh_0061	COG0805	protein transport
Adeh_0062	COG0183	Belongs to the thiolase family
Adeh_0066	COG1032	radical SAM domain protein
Adeh_0069	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Adeh_0070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Adeh_0075	COG0352	thiamine-phosphate diphosphorylase activity
Adeh_0076	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Adeh_0077	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Adeh_0077	COG0351	phosphomethylpyrimidine kinase
Adeh_0077	COG0352	thiamine-phosphate diphosphorylase activity
Adeh_0079	COG0305	Participates in initiation and elongation during chromosome replication
Adeh_0082	COG1346	cytolysis
Adeh_0083	COG1380	Effector of murein hydrolase LrgA
Adeh_0084	COG0583	DNA-binding transcription factor activity
Adeh_0085	COG1410	methionine synthase
Adeh_0085	COG0646	methionine synthase
Adeh_0089	COG0433	COG0433 Predicted ATPase
Adeh_0090	COG5002	protein histidine kinase activity
Adeh_0093	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Adeh_0094	COG1666	GTP binding
Adeh_0097	COG0210	DNA helicase
Adeh_0098	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Adeh_0099	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Adeh_0100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Adeh_0101	COG0745	RESPONSE REGULATOR receiver
Adeh_0101	COG3706	GGDEF domain
Adeh_0102	COG0612	Peptidase, M16
Adeh_0103	COG0612	Peptidase, M16
Adeh_0106	COG2204	response regulator
Adeh_0107	COG3852	Histidine kinase
Adeh_0112	COG1077	Cell shape determining protein MreB Mrl
Adeh_0113	COG1077	Cell shape determining protein MreB Mrl
Adeh_0114	COG1506	peptidase
Adeh_0114	COG0823	Involved in the tonB-independent uptake of proteins
Adeh_0116	COG0359	binds to the 23S rRNA
Adeh_0117	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Adeh_0118	COG0360	Binds together with S18 to 16S ribosomal RNA
Adeh_0119	COG0193	aminoacyl-tRNA hydrolase activity
Adeh_0120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Adeh_0121	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Adeh_0122	COG2088	sporulation resulting in formation of a cellular spore
Adeh_0123	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Adeh_0126	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Adeh_0127	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Adeh_0132	COG3706	GGDEF domain
Adeh_0135	COG0297	glycogen (starch) synthase activity
Adeh_0144	COG2204	response regulator
Adeh_0146	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Adeh_0147	COG1660	Displays ATPase and GTPase activities
Adeh_0148	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Adeh_0148	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Adeh_0151	COG3716	PTS system mannose fructose sorbose family IID component
Adeh_0154	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Adeh_0156	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Adeh_0157	COG1968	undecaprenyl-diphosphatase activity
Adeh_0159	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Adeh_0159	COG0662	Cupin 2, conserved barrel domain protein
Adeh_0161	COG1846	Transcriptional regulator
Adeh_0161	COG1940	carbohydrate kinase activity
Adeh_0171	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Adeh_0172	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Adeh_0175	COG2205	protein histidine kinase activity
Adeh_0175	COG0784	Response regulator, receiver
Adeh_0178	COG3138	arginine N-succinyltransferase
Adeh_0179	COG1490	D-aminoacyl-tRNA deacylase activity
Adeh_0180	COG0537	adenosine 5'-monophosphoramidase activity
Adeh_0184	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Adeh_0185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Adeh_0186	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Adeh_0187	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Adeh_0188	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Adeh_0189	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Adeh_0200	COG0109	protoheme IX farnesyltransferase activity
Adeh_0200	COG1612	heme a metabolic process
Adeh_0206	COG2814	Major facilitator Superfamily
Adeh_0211	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Adeh_0212	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Adeh_0214	COG2226	methyltransferase
Adeh_0216	COG0697	spore germination
Adeh_0218	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Adeh_0218	COG0674	pyruvate-flavodoxin oxidoreductase activity
Adeh_0218	COG1013	pyruvate-flavodoxin oxidoreductase activity
Adeh_0228	COG1309	transcriptional regulator
Adeh_0233	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Adeh_0234	COG1404	Belongs to the peptidase S8 family
Adeh_0235	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Adeh_0243	COG1297	OPT oligopeptide transporter protein
Adeh_0246	COG2264	protein methyltransferase activity
Adeh_0247	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Adeh_0250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Adeh_0252	COG1278	Cold shock
Adeh_0255	COG0204	Acyl-transferase
Adeh_0256	COG5002	protein histidine kinase activity
Adeh_0257	COG0439	Biotin carboxylase
Adeh_0258	COG5016	pyruvate
Adeh_0258	COG0511	ligase activity, forming carbon-carbon bonds
Adeh_0260	COG0484	heat shock protein binding
Adeh_0265	COG0564	pseudouridine synthase activity
Adeh_0266	COG0848	biopolymer transport protein
Adeh_0268	COG0811	peptide transport
Adeh_0272	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Adeh_0273	COG0052	Belongs to the universal ribosomal protein uS2 family
Adeh_0275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Adeh_0276	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Adeh_0276	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Adeh_0277	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Adeh_0278	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Adeh_0279	COG0617	tRNA 3'-terminal CCA addition
Adeh_0280	COG0528	UMP kinase activity
Adeh_0281	COG0233	cytoplasmic translational termination
Adeh_0285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Adeh_0285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Adeh_0291	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Adeh_0294	COG1640	4-alpha-glucanotransferase
Adeh_0295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Adeh_0299	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Adeh_0301	COG4191	Histidine kinase
Adeh_0303	COG2839	Protein conserved in bacteria
Adeh_0310	COG1942	4-Oxalocrotonate Tautomerase
Adeh_0312	COG0583	DNA-binding transcription factor activity
Adeh_0314	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Adeh_0322	COG4412	M6 family metalloprotease domain protein
Adeh_0322	COG3291	Pkd domain containing protein
Adeh_0324	COG0308	aminopeptidase N
Adeh_0325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Adeh_0327	COG2151	metal-sulfur cluster biosynthetic enzyme
Adeh_0336	COG4206	TonB-dependent receptor
Adeh_0347	COG0693	protein deglycase activity
Adeh_0348	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Adeh_0351	COG2855	membrane
Adeh_0352	COG0583	DNA-binding transcription factor activity
Adeh_0358	COG1024	Enoyl-CoA hydratase
Adeh_0358	COG1250	3-hydroxyacyl-CoA dehydrogenase
Adeh_0359	COG0183	Belongs to the thiolase family
Adeh_0360	COG1960	acyl-CoA dehydrogenase activity
Adeh_0363	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Adeh_0364	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Adeh_0365	COG2890	protein-(glutamine-N5) methyltransferase activity
Adeh_0366	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Adeh_0367	COG0784	Response regulator, receiver
Adeh_0367	COG2205	protein histidine kinase activity
Adeh_0370	COG0402	S-adenosylhomocysteine deaminase activity
Adeh_0371	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Adeh_0372	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Adeh_0373	COG0163	prenyltransferase activity
Adeh_0374	COG2226	methyltransferase
Adeh_0375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Adeh_0377	COG0612	Peptidase, M16
Adeh_0385	COG0542	response to heat
Adeh_0386	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Adeh_0389	COG0318	PFAM AMP-dependent synthetase and ligase
Adeh_0396	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Adeh_0401	COG1234	tRNA 3'-trailer cleavage
Adeh_0402	COG1741	Belongs to the pirin family
Adeh_0404	COG1131	(ABC) transporter
Adeh_0407	COG0183	Belongs to the thiolase family
Adeh_0408	COG1024	Enoyl-CoA hydratase
Adeh_0408	COG1250	3-hydroxyacyl-CoA dehydrogenase
Adeh_0411	COG0745	RESPONSE REGULATOR receiver
Adeh_0412	COG1921	L-seryl-tRNASec selenium transferase activity
Adeh_0413	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Adeh_0418	COG3852	Histidine kinase
Adeh_0420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Adeh_0421	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Adeh_0423	COG1088	dTDP-glucose 4,6-dehydratase activity
Adeh_0424	COG0204	Acyl-transferase
Adeh_0426	COG1846	Transcriptional regulator
Adeh_0429	COG3706	GGDEF domain
Adeh_0431	COG0708	Exodeoxyribonuclease III
Adeh_0434	COG0420	3'-5' exonuclease activity
Adeh_0436	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Adeh_0441	COG0577	efflux transmembrane transporter activity
Adeh_0441	COG1136	(ABC) transporter
Adeh_0448	COG1309	transcriptional regulator
Adeh_0450	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Adeh_0452	COG0667	Aldo Keto reductase
Adeh_0455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Adeh_0455	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Adeh_0456	COG3639	organic phosphonate transmembrane transporter activity
Adeh_0457	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Adeh_0464	COG0439	Biotin carboxylase
Adeh_0468	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Adeh_0469	COG3875	lactate racemase activity
Adeh_0475	COG0298	carbon dioxide binding
Adeh_0476	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Adeh_0477	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Adeh_0478	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Adeh_0479	COG5557	Pfam Polysulphide reductase, NrfD
Adeh_0480	COG0437	4 iron, 4 sulfur cluster binding
Adeh_0481	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Adeh_0487	COG1285	pathogenesis
Adeh_0488	COG2119	membrane
Adeh_0493	COG1122	ATPase activity
Adeh_0495	COG0310	cobalt ion transport
Adeh_0497	COG0864	Transcriptional regulator
Adeh_0498	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Adeh_0498	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Adeh_0503	COG2205	protein histidine kinase activity
Adeh_0506	COG5002	protein histidine kinase activity
Adeh_0507	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Adeh_0507	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Adeh_0509	COG2133	pyrroloquinoline quinone binding
Adeh_0510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Adeh_0516	COG1538	Outer membrane efflux protein
Adeh_0519	COG1309	transcriptional regulator
Adeh_0520	COG0366	Alpha amylase catalytic
Adeh_0522	COG0596	Alpha beta hydrolase
Adeh_0524	COG2832	Protein of unknown function (DUF454)
Adeh_0530	COG0671	phosphoesterase, PA-phosphatase related
Adeh_0531	COG1752	Esterase of the alpha-beta hydrolase superfamily
Adeh_0533	COG0436	Aminotransferase
Adeh_0535	COG3047	cAMP biosynthetic process
Adeh_0538	COG1122	ATPase activity
Adeh_0539	COG1268	BioY protein
Adeh_0540	COG0400	carboxylic ester hydrolase activity
Adeh_0542	COG0583	DNA-binding transcription factor activity
Adeh_0544	COG0667	Aldo Keto reductase
Adeh_0548	COG0596	Alpha beta hydrolase
Adeh_0549	COG0583	DNA-binding transcription factor activity
Adeh_0551	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_0562	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Adeh_0563	COG0784	Response regulator, receiver
Adeh_0563	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Adeh_0567	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Adeh_0569	COG1228	amidohydrolase
Adeh_0570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Adeh_0571	COG2204	response regulator
Adeh_0576	COG0612	Peptidase, M16
Adeh_0577	COG5002	protein histidine kinase activity
Adeh_0582	COG0745	RESPONSE REGULATOR receiver
Adeh_0586	COG1438	arginine binding
Adeh_0587	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Adeh_0588	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Adeh_0591	COG4232	protein-disulfide reductase activity
Adeh_0592	COG1104	cysteine desulfurase activity
Adeh_0594	COG0316	Belongs to the HesB IscA family
Adeh_0595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Adeh_0597	COG0443	Heat shock 70 kDa protein
Adeh_0600	COG2201	protein-glutamate methylesterase activity
Adeh_0602	COG0835	chemotaxis
Adeh_0603	COG0643	Histidine kinase
Adeh_0603	COG2198	Histidine kinase
Adeh_0604	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Adeh_0606	COG0745	RESPONSE REGULATOR receiver
Adeh_0609	COG0745	RESPONSE REGULATOR receiver
Adeh_0614	COG2201	protein-glutamate methylesterase activity
Adeh_0616	COG0784	Response regulator, receiver
Adeh_0617	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Adeh_0618	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Adeh_0620	COG0295	cytidine deaminase activity
Adeh_0621	COG0196	riboflavin kinase activity
Adeh_0622	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Adeh_0625	COG3852	Histidine kinase
Adeh_0635	COG4968	Prepilin-type N-terminal cleavage methylation domain
Adeh_0636	COG1131	(ABC) transporter
Adeh_0637	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Adeh_0639	COG2204	response regulator
Adeh_0648	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Adeh_0649	COG0511	ligase activity, forming carbon-carbon bonds
Adeh_0650	COG0439	Biotin carboxylase
Adeh_0652	COG3267	Type II secretory pathway component ExeA
Adeh_0652	COG3409	Peptidoglycan-binding domain 1 protein
Adeh_0655	COG2217	Heavy metal translocating P-type atpase
Adeh_0659	COG0823	Involved in the tonB-independent uptake of proteins
Adeh_0664	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Adeh_0666	COG2884	Cell division ATP-binding protein ftsE
Adeh_0667	COG2177	Part of the ABC transporter FtsEX involved in
Adeh_0668	COG4942	peptidase
Adeh_0669	COG0793	Belongs to the peptidase S41A family
Adeh_0670	COG1215	transferase activity, transferring glycosyl groups
Adeh_0672	COG0546	phosphoglycolate phosphatase activity
Adeh_0673	COG0552	protein localization to endoplasmic reticulum
Adeh_0674	COG1196	nuclear chromosome segregation
Adeh_0675	COG3290	protein histidine kinase activity
Adeh_0675	COG0840	transmembrane signaling receptor activity
Adeh_0682	COG2165	general secretion pathway protein
Adeh_0685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Adeh_0686	COG1450	Type ii and iii secretion system protein
Adeh_0689	COG0254	rRNA binding
Adeh_0690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Adeh_0693	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Adeh_0694	COG1254	Belongs to the acylphosphatase family
Adeh_0696	COG1530	ribonuclease E activity
Adeh_0696	COG1530	ribonuclease E activity
Adeh_0697	COG1295	ribonuclease BN
Adeh_0698	COG0776	regulation of translation
Adeh_0700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Adeh_0702	COG1987	bacterial-type flagellum assembly
Adeh_0705	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Adeh_0711	COG2197	response regulator
Adeh_0712	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Adeh_0713	COG0131	Imidazoleglycerol-phosphate dehydratase
Adeh_0714	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Adeh_0715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Adeh_0716	COG0107	imidazoleglycerol-phosphate synthase activity
Adeh_0723	COG0406	alpha-ribazole phosphatase activity
Adeh_0723	COG0328	RNA-DNA hybrid ribonuclease activity
Adeh_0724	COG1584	GPR1 FUN34 yaaH family protein
Adeh_0725	COG0242	peptide deformylase activity
Adeh_0727	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Adeh_0730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Adeh_0731	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Adeh_0732	COG0497	DNA recombination
Adeh_0733	COG0631	protein serine/threonine phosphatase activity
Adeh_0734	COG0739	heme binding
Adeh_0736	COG0653	protein targeting
Adeh_0742	COG1595	DNA-templated transcription, initiation
Adeh_0745	COG0604	alcohol dehydrogenase
Adeh_0746	COG0583	DNA-binding transcription factor activity
Adeh_0747	COG0628	permease
Adeh_0750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Adeh_0751	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Adeh_0752	COG0739	heme binding
Adeh_0753	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Adeh_0756	COG1881	PFAM PEBP family protein
Adeh_0759	COG0348	domain, Protein
Adeh_0760	COG2962	Rard protein
Adeh_0761	COG0589	response to stress
Adeh_0766	COG0247	lactate metabolic process
Adeh_0778	COG1253	flavin adenine dinucleotide binding
Adeh_0780	COG2264	protein methyltransferase activity
Adeh_0782	COG0508	dehydrogenase complex catalyzes the overall conversion of
Adeh_0787	COG1643	Atp-dependent helicase
Adeh_0788	COG0071	Belongs to the small heat shock protein (HSP20) family
Adeh_0792	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Adeh_0794	COG1595	DNA-templated transcription, initiation
Adeh_0796	COG0437	4 iron, 4 sulfur cluster binding
Adeh_0803	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Adeh_0805	COG1845	cytochrome c oxidase, subunit III
Adeh_0808	COG0028	Belongs to the TPP enzyme family
Adeh_0809	COG4948	Mandelate Racemase Muconate Lactonizing
Adeh_0810	COG0277	FAD linked oxidase domain protein
Adeh_0810	COG0247	lactate metabolic process
Adeh_0811	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Adeh_0813	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Adeh_0816	COG1793	dna ligase
Adeh_0817	COG0067	glutamate synthase
Adeh_0817	COG0070	glutamate synthase
Adeh_0817	COG0069	glutamate synthase activity
Adeh_0818	COG0493	'glutamate synthase
Adeh_0821	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Adeh_0823	COG0437	4 iron, 4 sulfur cluster binding
Adeh_0824	COG0243	molybdopterin cofactor binding
Adeh_0824	COG3383	formate dehydrogenase (NAD+) activity
Adeh_0825	COG0243	molybdopterin cofactor binding
Adeh_0826	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Adeh_0827	COG3973	AAA domain
Adeh_0828	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Adeh_0830	COG0488	(ABC) transporter
Adeh_0831	COG1012	belongs to the aldehyde dehydrogenase family
Adeh_0834	COG4191	Histidine kinase
Adeh_0835	COG1131	(ABC) transporter
Adeh_0836	COG0842	Transport permease protein
Adeh_0838	COG0514	ATP-dependent DNA helicase (RecQ)
Adeh_0841	COG4681	YaeQ
Adeh_0843	COG0719	Fe-S assembly protein
Adeh_0844	COG0396	ATPase activity
Adeh_0845	COG0719	Fe-S assembly protein
Adeh_0846	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Adeh_0852	COG0793	Belongs to the peptidase S41A family
Adeh_0854	COG1136	(ABC) transporter
Adeh_0854	COG0577	efflux transmembrane transporter activity
Adeh_0855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Adeh_0857	COG2197	response regulator
Adeh_0860	COG0023	Translation Initiation Factor
Adeh_0863	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Adeh_0864	COG0058	SHG alpha-glucan phosphorylase activity
Adeh_0867	COG1704	LemA family
Adeh_0872	COG1396	sequence-specific DNA binding
Adeh_0873	COG0745	RESPONSE REGULATOR receiver
Adeh_0887	COG0668	transmembrane transport
Adeh_0891	COG0745	RESPONSE REGULATOR receiver
Adeh_0892	COG2205	protein histidine kinase activity
Adeh_0893	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Adeh_0894	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Adeh_0895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Adeh_0898	COG2322	membrane
Adeh_0901	COG0109	protoheme IX farnesyltransferase activity
Adeh_0903	COG0037	tRNA processing
Adeh_0904	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Adeh_0905	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Adeh_0908	COG0243	molybdopterin cofactor binding
Adeh_0910	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Adeh_0912	COG2132	Multicopper oxidase
Adeh_0922	COG2204	response regulator
Adeh_0923	COG4191	Histidine kinase
Adeh_0924	COG2873	o-acetylhomoserine
Adeh_0927	COG0432	Pfam Uncharacterised protein family UPF0047
Adeh_0928	COG0003	Pfam Anion-transporting ATPase
Adeh_0930	COG1192	Involved in chromosome partitioning
Adeh_0932	COG2353	YceI-like domain
Adeh_0933	COG3384	dioxygenase
Adeh_0934	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Adeh_0937	COG0584	glycerophosphoryl diester phosphodiesterase
Adeh_0939	COG1271	oxidase subunit
Adeh_0940	COG1294	oxidase, subunit
Adeh_0943	COG1331	Highly conserved protein containing a thioredoxin domain
Adeh_0949	COG3158	transport of potassium into the cell
Adeh_0950	COG2814	Major facilitator Superfamily
Adeh_0951	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Adeh_0952	COG0632	four-way junction helicase activity
Adeh_0953	COG2255	four-way junction helicase activity
Adeh_0955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Adeh_0962	COG3285	dna ligase
Adeh_0962	COG1793	dna ligase
Adeh_0965	COG0427	acetyl-CoA hydrolase
Adeh_0967	COG0745	RESPONSE REGULATOR receiver
Adeh_0969	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Adeh_0976	COG2814	Major facilitator Superfamily
Adeh_0983	COG2205	protein histidine kinase activity
Adeh_0983	COG2202	Pas domain
Adeh_0985	COG4783	chaperone-mediated protein folding
Adeh_0988	COG1278	Cold shock
Adeh_0993	COG1720	tRNA m6t6A37 methyltransferase activity
Adeh_0998	COG3842	ATPase activity
Adeh_1005	COG1129	ABC transporter
Adeh_1006	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Adeh_1017	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Adeh_1021	COG3239	Fatty acid desaturase
Adeh_1022	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Adeh_1023	COG0798	PFAM Bile acid sodium symporter
Adeh_1029	COG2226	methyltransferase
Adeh_1030	COG1335	isochorismatase
Adeh_1040	COG1335	isochorismatase
Adeh_1041	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Adeh_1043	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Adeh_1044	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Adeh_1045	COG1692	metallophosphoesterase
Adeh_1050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Adeh_1054	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Adeh_1055	COG2204	response regulator
Adeh_1061	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Adeh_1063	COG0673	inositol 2-dehydrogenase activity
Adeh_1067	COG1132	(ABC) transporter
Adeh_1068	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Adeh_1069	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Adeh_1070	COG4221	oxidoreductase activity
Adeh_1071	COG5000	phosphorelay sensor kinase activity
Adeh_1076	COG1543	Belongs to the glycosyl hydrolase 57 family
Adeh_1078	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Adeh_1081	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Adeh_1083	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Adeh_1084	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Adeh_1086	COG3494	Protein of unknown function (DUF1009)
Adeh_1087	COG1872	DUF167
Adeh_1088	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Adeh_1089	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Adeh_1090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Adeh_1091	COG0484	heat shock protein binding
Adeh_1093	COG1570	exodeoxyribonuclease VII activity
Adeh_1094	COG1722	exodeoxyribonuclease VII activity
Adeh_1095	COG0745	RESPONSE REGULATOR receiver
Adeh_1096	COG0142	geranyltranstransferase activity
Adeh_1097	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Adeh_1098	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Adeh_1099	COG0779	Required for maturation of 30S ribosomal subunits
Adeh_1102	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Adeh_1104	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Adeh_1105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Adeh_1107	COG1185	polyribonucleotide nucleotidyltransferase activity
Adeh_1108	COG0756	dUTP diphosphatase activity
Adeh_1109	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Adeh_1111	COG5002	protein histidine kinase activity
Adeh_1115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Adeh_1117	COG0546	phosphoglycolate phosphatase activity
Adeh_1119	COG0745	RESPONSE REGULATOR receiver
Adeh_1120	COG0314	molybdopterin synthase activity
Adeh_1121	COG0750	zinc metalloprotease
Adeh_1123	COG2816	NAD+ diphosphatase activity
Adeh_1130	COG5002	protein histidine kinase activity
Adeh_1132	COG1960	acyl-CoA dehydrogenase activity
Adeh_1133	COG1324	tolerance protein
Adeh_1135	COG0515	serine threonine protein kinase
Adeh_1138	COG0616	signal peptide processing
Adeh_1139	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Adeh_1140	COG1607	acyl-coa hydrolase
Adeh_1144	COG1408	metallophosphoesterase
Adeh_1148	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Adeh_1149	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Adeh_1154	COG1100	Small GTP-binding protein
Adeh_1160	COG0840	transmembrane signaling receptor activity
Adeh_1161	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Adeh_1161	COG2755	lipolytic protein G-D-S-L family
Adeh_1162	COG1064	alcohol dehydrogenase
Adeh_1165	COG0318	PFAM AMP-dependent synthetase and ligase
Adeh_1166	COG3875	lactate racemase activity
Adeh_1170	COG0243	molybdopterin cofactor binding
Adeh_1171	COG3278	Belongs to the heme-copper respiratory oxidase family
Adeh_1174	COG0348	domain, Protein
Adeh_1177	COG2217	Heavy metal translocating P-type atpase
Adeh_1179	COG1049	propionate catabolic process, 2-methylcitrate cycle
Adeh_1180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Adeh_1181	COG1573	uracil-dna glycosylase
Adeh_1185	COG1309	transcriptional regulator
Adeh_1189	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeh_1191	COG2205	protein histidine kinase activity
Adeh_1192	COG2201	protein-glutamate methylesterase activity
Adeh_1193	COG0643	Histidine kinase
Adeh_1193	COG2198	Histidine kinase
Adeh_1197	COG1269	ATP hydrolysis coupled proton transport
Adeh_1202	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Adeh_1203	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Adeh_1204	COG1394	ATPase activity, coupled to movement of substances
Adeh_1206	COG5002	protein histidine kinase activity
Adeh_1207	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_1209	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Adeh_1213	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Adeh_1216	COG3411	Ferredoxin
Adeh_1218	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Adeh_1220	COG1047	Peptidyl-prolyl cis-trans
Adeh_1228	COG2719	SpoVR family
Adeh_1229	COG2718	Belongs to the UPF0229 family
Adeh_1230	COG2766	serine protein kinase
Adeh_1231	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Adeh_1232	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Adeh_1235	COG1278	Cold shock
Adeh_1236	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Adeh_1238	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Adeh_1242	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Adeh_1243	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Adeh_1245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Adeh_1247	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Adeh_1249	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Adeh_1252	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Adeh_1254	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Adeh_1255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Adeh_1256	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Adeh_1257	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Adeh_1260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Adeh_1261	COG1309	transcriptional regulator
Adeh_1262	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Adeh_1264	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Adeh_1265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Adeh_1270	COG0658	competence protein
Adeh_1270	COG2333	competence protein COMEC
Adeh_1272	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Adeh_1272	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Adeh_1273	COG0215	cysteine-tRNA ligase activity
Adeh_1274	COG1278	Cold shock
Adeh_1275	COG0556	nucleotide-excision repair
Adeh_1278	COG3258	Cytochrome c
Adeh_1279	COG0322	excinuclease ABC activity
Adeh_1281	COG1045	serine acetyltransferase
Adeh_1284	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Adeh_1285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Adeh_1287	COG0483	inositol monophosphate 1-phosphatase activity
Adeh_1289	COG2937	Belongs to the GPAT DAPAT family
Adeh_1294	COG0167	dihydroorotate dehydrogenase activity
Adeh_1297	COG0741	lytic transglycosylase activity
Adeh_1298	COG0602	queuosine metabolic process
Adeh_1303	COG1381	Involved in DNA repair and RecF pathway recombination
Adeh_1305	COG0752	glycyl-tRNA synthetase alpha subunit
Adeh_1306	COG0751	glycine-tRNA ligase activity
Adeh_1311	COG3599	regulation of cell shape
Adeh_1312	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Adeh_1314	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Adeh_1314	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Adeh_1315	COG0084	hydrolase, TatD family'
Adeh_1318	COG1335	isochorismatase
Adeh_1326	COG2204	response regulator
Adeh_1327	COG4191	Histidine kinase
Adeh_1328	COG0745	RESPONSE REGULATOR receiver
Adeh_1328	COG4566	intracellular signal transduction
Adeh_1329	COG2205	protein histidine kinase activity
Adeh_1330	COG2239	Acts as a magnesium transporter
Adeh_1332	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Adeh_1334	COG0303	'Molybdopterin
Adeh_1337	COG0463	Glycosyl transferase, family 2
Adeh_1337	COG0457	Tetratricopeptide repeat
Adeh_1339	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Adeh_1341	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Adeh_1342	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Adeh_1347	COG0739	heme binding
Adeh_1348	COG1706	bacterial-type flagellum-dependent cell motility
Adeh_1349	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Adeh_1351	COG4786	Flagellar basal body rod
Adeh_1352	COG4786	Flagellar basal body rod
Adeh_1356	COG0455	bacterial-type flagellum organization
Adeh_1359	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Adeh_1360	COG1684	flagellar biosynthetic protein fliR
Adeh_1361	COG1987	bacterial-type flagellum assembly
Adeh_1362	COG1338	Plays a role in the flagellum-specific transport system
Adeh_1367	COG1639	'signal transduction protein
Adeh_1368	COG0745	RESPONSE REGULATOR receiver
Adeh_1372	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Adeh_1373	COG2201	protein-glutamate methylesterase activity
Adeh_1374	COG0840	transmembrane signaling receptor activity
Adeh_1375	COG0835	chemotaxis
Adeh_1378	COG0745	RESPONSE REGULATOR receiver
Adeh_1379	COG0643	Histidine kinase
Adeh_1379	COG2198	Histidine kinase
Adeh_1380	COG0840	transmembrane signaling receptor activity
Adeh_1381	COG0835	chemotaxis
Adeh_1382	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Adeh_1383	COG2201	protein-glutamate methylesterase activity
Adeh_1385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Adeh_1393	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Adeh_1395	COG1677	Flagellar hook-basal body complex protein FliE
Adeh_1396	COG1558	bacterial-type flagellum-dependent cell motility
Adeh_1401	COG3604	Transcriptional regulator
Adeh_1406	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Adeh_1407	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Adeh_1408	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Adeh_1421	COG0038	chloride channel
Adeh_1423	COG0437	4 iron, 4 sulfur cluster binding
Adeh_1427	COG0429	hydrolase of the alpha beta-hydrolase fold
Adeh_1428	COG0343	queuine tRNA-ribosyltransferase activity
Adeh_1432	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Adeh_1438	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Adeh_1439	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Adeh_1440	COG0363	glucosamine-6-phosphate deaminase activity
Adeh_1441	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Adeh_1442	COG3387	PFAM Glycoside hydrolase 15-related
Adeh_1447	COG1067	ATP-dependent peptidase activity
Adeh_1448	COG0589	response to stress
Adeh_1449	COG0517	IMP dehydrogenase activity
Adeh_1450	COG2204	response regulator
Adeh_1451	COG4191	Histidine kinase
Adeh_1455	COG0259	pyridoxamine-phosphate oxidase activity
Adeh_1456	COG2353	YceI-like domain
Adeh_1462	COG4974	Belongs to the 'phage' integrase family
Adeh_1467	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Adeh_1477	COG1538	Outer membrane efflux protein
Adeh_1480	COG0617	tRNA 3'-terminal CCA addition
Adeh_1481	COG0784	Response regulator, receiver
Adeh_1481	COG2198	Histidine kinase
Adeh_1481	COG2205	protein histidine kinase activity
Adeh_1482	COG0482	sulfurtransferase activity
Adeh_1483	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Adeh_1485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Adeh_1486	COG1607	acyl-coa hydrolase
Adeh_1487	COG3246	L-lysine catabolic process to acetate
Adeh_1488	COG0776	regulation of translation
Adeh_1491	COG0004	ammonium transporteR
Adeh_1494	COG0590	tRNA wobble adenosine to inosine editing
Adeh_1494	COG0037	tRNA processing
Adeh_1495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Adeh_1496	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Adeh_1497	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Adeh_1499	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Adeh_1500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Adeh_1501	COG0736	holo-[acyl-carrier-protein] synthase activity
Adeh_1502	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Adeh_1502	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Adeh_1503	COG0802	atpase or kinase
Adeh_1507	COG1228	amidohydrolase
Adeh_1508	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Adeh_1512	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Adeh_1513	COG0825	malonyl-CoA metabolic process
Adeh_1515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Adeh_1520	COG0539	negative regulation of cytoplasmic translation
Adeh_1520	COG2183	response to ionizing radiation
Adeh_1521	COG0616	signal peptide processing
Adeh_1524	COG0018	arginyl-trna synthetase
Adeh_1528	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Adeh_1530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Adeh_1531	COG0126	phosphoglycerate kinase activity
Adeh_1532	COG0149	triose-phosphate isomerase activity
Adeh_1536	COG0443	Heat shock 70 kDa protein
Adeh_1538	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Adeh_1541	COG0529	Catalyzes the synthesis of activated sulfate
Adeh_1541	COG2046	Belongs to the sulfate adenylyltransferase family
Adeh_1544	COG0101	tRNA pseudouridine synthase activity
Adeh_1547	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Adeh_1549	COG0443	Heat shock 70 kDa protein
Adeh_1550	COG2766	serine protein kinase
Adeh_1550	COG2766	serine protein kinase
Adeh_1553	COG2843	Capsule synthesis protein
Adeh_1554	COG4191	Histidine kinase
Adeh_1555	COG2204	response regulator
Adeh_1556	COG0745	RESPONSE REGULATOR receiver
Adeh_1556	COG3706	GGDEF domain
Adeh_1567	COG1730	sister chromatid segregation
Adeh_1576	COG3706	GGDEF domain
Adeh_1576	COG0745	RESPONSE REGULATOR receiver
Adeh_1577	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Adeh_1578	COG2921	Belongs to the UPF0250 family
Adeh_1580	COG0443	Heat shock 70 kDa protein
Adeh_1581	COG0189	ligase activity
Adeh_1583	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Adeh_1584	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Adeh_1589	COG0081	regulation of translation
Adeh_1590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Adeh_1591	COG0222	ribosome binding
Adeh_1592	COG0085	RNA polymerase activity
Adeh_1593	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Adeh_1598	COG0745	RESPONSE REGULATOR receiver
Adeh_1606	COG4191	Histidine kinase
Adeh_1607	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Adeh_1608	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Adeh_1610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Adeh_1612	COG0587	DNA-directed DNA polymerase activity
Adeh_1613	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Adeh_1614	COG0481	GTPase activity
Adeh_1615	COG0681	Belongs to the peptidase S26 family
Adeh_1617	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Adeh_1618	COG0540	Belongs to the ATCase OTCase family
Adeh_1619	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Adeh_1620	COG0505	Belongs to the CarA family
Adeh_1623	COG5002	protein histidine kinase activity
Adeh_1625	COG0538	isocitrate dehydrogenase activity
Adeh_1626	COG0039	L-malate dehydrogenase activity
Adeh_1627	COG0045	succinate-CoA ligase (ADP-forming) activity
Adeh_1628	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Adeh_1629	COG0105	UTP biosynthetic process
Adeh_1630	COG1253	flavin adenine dinucleotide binding
Adeh_1631	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Adeh_1640	COG1494	fructose-1,6-bisphosphatase
Adeh_1642	COG0148	phosphopyruvate hydratase activity
Adeh_1643	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Adeh_1645	COG1024	Enoyl-CoA hydratase
Adeh_1646	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Adeh_1647	COG1960	acyl-CoA dehydrogenase activity
Adeh_1649	COG1703	isobutyryl-CoA mutase activity
Adeh_1650	COG0571	ribonuclease III activity
Adeh_1653	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Adeh_1654	COG1160	GTP binding
Adeh_1657	COG0494	nUDIX hydrolase
Adeh_1659	COG3005	denitrification pathway
Adeh_1663	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Adeh_1663	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Adeh_1664	COG1960	acyl-CoA dehydrogenase activity
Adeh_1665	COG1960	acyl-CoA dehydrogenase activity
Adeh_1666	COG1024	Enoyl-CoA hydratase
Adeh_1667	COG1250	3-hydroxyacyl-CoA dehydrogenase
Adeh_1668	COG2205	protein histidine kinase activity
Adeh_1674	COG0489	protein tyrosine kinase activity
Adeh_1675	COG0598	Magnesium transport protein CorA
Adeh_1676	COG0430	RNA-3'-phosphate cyclase activity
Adeh_1678	COG1595	DNA-templated transcription, initiation
Adeh_1682	COG1187	pseudouridine synthase activity
Adeh_1683	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Adeh_1684	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Adeh_1685	COG0180	Tryptophanyl-tRNA synthetase
Adeh_1686	COG1994	Peptidase M50
Adeh_1687	COG4974	Belongs to the 'phage' integrase family
Adeh_1688	COG0009	L-threonylcarbamoyladenylate synthase
Adeh_1691	COG0189	ligase activity
Adeh_1692	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Adeh_1694	COG0860	N-Acetylmuramoyl-L-alanine amidase
Adeh_1695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Adeh_1698	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Adeh_1701	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Adeh_1707	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Adeh_1709	COG2815	serine threonine protein kinase
Adeh_1709	COG0515	serine threonine protein kinase
Adeh_1711	COG2204	response regulator
Adeh_1715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Adeh_1720	COG1058	Belongs to the CinA family
Adeh_1720	COG1546	Belongs to the CinA family
Adeh_1721	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Adeh_1724	COG0436	Aminotransferase
Adeh_1726	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Adeh_1727	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Adeh_1729	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Adeh_1732	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Adeh_1733	COG0742	ribosomal rna small subunit methyltransferase
Adeh_1744	COG0024	Methionine aminopeptidase
Adeh_1755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Adeh_1756	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Adeh_1757	COG1027	Aspartate ammonia-lyase
Adeh_1758	COG2204	response regulator
Adeh_1759	COG4191	Histidine kinase
Adeh_1759	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Adeh_1762	COG2197	response regulator
Adeh_1766	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Adeh_1771	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Adeh_1772	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Adeh_1776	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Adeh_1782	COG2205	protein histidine kinase activity
Adeh_1807	COG0443	Heat shock 70 kDa protein
Adeh_1808	COG0210	DNA helicase
Adeh_1814	COG2986	histidine ammonia-lyase
Adeh_1815	COG0527	aspartate kinase activity
Adeh_1818	COG2815	serine threonine protein kinase
Adeh_1818	COG0515	serine threonine protein kinase
Adeh_1822	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Adeh_1823	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Adeh_1826	COG0022	dehydrogenase e1 component
Adeh_1827	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Adeh_1828	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Adeh_1830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Adeh_1832	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Adeh_1854	COG1024	Enoyl-CoA hydratase
Adeh_1858	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Adeh_1860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Adeh_1862	COG1127	ABC transporter
Adeh_1863	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Adeh_1865	COG0564	pseudouridine synthase activity
Adeh_1892	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Adeh_1896	COG1166	arginine decarboxylase activity
Adeh_1898	COG2226	methyltransferase
Adeh_1901	COG0564	pseudouridine synthase activity
Adeh_1904	COG2894	cell division
Adeh_1906	COG0741	lytic transglycosylase activity
Adeh_1907	COG5002	protein histidine kinase activity
Adeh_1909	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Adeh_1910	COG0792	nuclease activity
Adeh_1912	COG0335	large ribosomal subunit rRNA binding
Adeh_1913	COG0336	Belongs to the RNA methyltransferase TrmD family
Adeh_1914	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Adeh_1915	COG1837	Belongs to the UPF0109 family
Adeh_1918	COG0203	ribosomal protein L17
Adeh_1919	COG0202	RNA polymerase activity
Adeh_1921	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Adeh_1922	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Adeh_1925	COG0563	adenylate kinase activity
Adeh_1926	COG0201	protein transport
Adeh_1927	COG0200	Binds to the 23S rRNA
Adeh_1929	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Adeh_1930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Adeh_1931	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Adeh_1932	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Adeh_1935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Adeh_1938	COG0255	Belongs to the universal ribosomal protein uL29 family
Adeh_1939	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Adeh_1940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Adeh_1942	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Adeh_1943	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Adeh_1944	COG0089	rRNA binding
Adeh_1945	COG0088	Forms part of the polypeptide exit tunnel
Adeh_1947	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Adeh_1948	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Adeh_1949	COG0049	tRNA binding
Adeh_1952	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Adeh_1953	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Adeh_1958	COG1013	pyruvate-flavodoxin oxidoreductase activity
Adeh_1959	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Adeh_1959	COG0674	pyruvate-flavodoxin oxidoreductase activity
Adeh_1961	COG1013	pyruvate-flavodoxin oxidoreductase activity
Adeh_1962	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Adeh_1962	COG0674	pyruvate-flavodoxin oxidoreductase activity
Adeh_1963	COG0277	FAD linked oxidase domain protein
Adeh_1965	COG0302	gtp cyclohydrolase
Adeh_1966	COG0720	synthase
Adeh_1967	COG2146	nitrite reductase [NAD(P)H] activity
Adeh_1969	COG0776	regulation of translation
Adeh_1971	COG0072	phenylalanine-tRNA ligase activity
Adeh_1972	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Adeh_1973	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Adeh_1974	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Adeh_1975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Adeh_1979	COG0066	3-isopropylmalate dehydratase activity
Adeh_1980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Adeh_1981	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Adeh_1982	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Adeh_1984	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Adeh_1988	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Adeh_1991	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Adeh_1992	COG2204	response regulator
Adeh_1993	COG4191	Histidine kinase
Adeh_1994	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Adeh_1997	COG2197	response regulator
Adeh_1998	COG4585	Histidine kinase
Adeh_2005	COG0509	glycine decarboxylation via glycine cleavage system
Adeh_2006	COG5557	Pfam Polysulphide reductase, NrfD
Adeh_2007	COG0437	4 iron, 4 sulfur cluster binding
Adeh_2007	COG3064	Membrane
Adeh_2009	COG2204	response regulator
Adeh_2011	COG5002	protein histidine kinase activity
Adeh_2012	COG0788	formyltetrahydrofolate deformylase activity
Adeh_2014	COG0408	coproporphyrinogen oxidase activity
Adeh_2015	COG3145	DNA-N1-methyladenine dioxygenase activity
Adeh_2017	COG0583	DNA-binding transcription factor activity
Adeh_2022	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Adeh_2028	COG0656	L-ascorbic acid biosynthetic process
Adeh_2036	COG4953	penicillin-binding protein 1C
Adeh_2037	COG2373	Large extracellular alpha-helical protein
Adeh_2039	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Adeh_2043	COG1136	(ABC) transporter
Adeh_2046	COG2095	MarC family integral membrane protein
Adeh_2047	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Adeh_2049	COG0351	phosphomethylpyrimidine kinase
Adeh_2051	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Adeh_2055	COG1164	Oligoendopeptidase f
Adeh_2057	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Adeh_2059	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Adeh_2061	COG0488	(ABC) transporter
Adeh_2067	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Adeh_2068	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Adeh_2068	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Adeh_2069	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Adeh_2069	COG2755	lipolytic protein G-D-S-L family
Adeh_2070	COG0473	3-isopropylmalate dehydrogenase activity
Adeh_2071	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Adeh_2076	COG0667	Aldo Keto reductase
Adeh_2077	COG0328	RNA-DNA hybrid ribonuclease activity
Adeh_2079	COG2195	Cleaves the N-terminal amino acid of tripeptides
Adeh_2084	COG0626	cystathionine gamma-synthase activity
Adeh_2087	COG0437	4 iron, 4 sulfur cluster binding
Adeh_2087	COG3064	Membrane
Adeh_2088	COG0243	molybdopterin cofactor binding
Adeh_2088	COG3383	formate dehydrogenase (NAD+) activity
Adeh_2090	COG0784	Response regulator, receiver
Adeh_2090	COG2205	protein histidine kinase activity
Adeh_2091	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Adeh_2092	COG1201	RNA secondary structure unwinding
Adeh_2094	COG0156	8-amino-7-oxononanoate synthase activity
Adeh_2095	COG1063	alcohol dehydrogenase
Adeh_2096	COG1053	succinate dehydrogenase
Adeh_2100	COG1301	dicarboxylic acid transport
Adeh_2101	COG2204	response regulator
Adeh_2102	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Adeh_2102	COG4191	Histidine kinase
Adeh_2103	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Adeh_2106	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Adeh_2107	COG2226	methyltransferase
Adeh_2108	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Adeh_2109	COG0686	Belongs to the AlaDH PNT family
Adeh_2112	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Adeh_2114	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Adeh_2120	COG0667	Aldo Keto reductase
Adeh_2121	COG1595	DNA-templated transcription, initiation
Adeh_2124	COG0515	serine threonine protein kinase
Adeh_2130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Adeh_2131	COG0508	dehydrogenase complex catalyzes the overall conversion of
Adeh_2133	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Adeh_2136	COG0410	ABC transporter
Adeh_2138	COG0559	Belongs to the binding-protein-dependent transport system permease family
Adeh_2140	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_2142	COG0252	asparaginase activity
Adeh_2143	COG2814	Major facilitator Superfamily
Adeh_2146	COG0785	Cytochrome C biogenesis protein
Adeh_2153	COG1252	NADH dehydrogenase
Adeh_2154	COG2818	Glycosylase
Adeh_2157	COG0488	(ABC) transporter
Adeh_2168	COG4191	Histidine kinase
Adeh_2170	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Adeh_2171	COG1140	nitrate reductase beta subunit
Adeh_2174	COG2223	nitrite transmembrane transporter activity
Adeh_2176	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Adeh_2178	COG0730	response to heat
Adeh_2179	COG0683	leucine binding
Adeh_2182	COG0410	ABC transporter
Adeh_2184	COG0217	transcriptional regulatory protein
Adeh_2186	COG0835	chemotaxis
Adeh_2187	COG0840	transmembrane signaling receptor activity
Adeh_2193	COG1592	Rubrerythrin
Adeh_2194	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Adeh_2197	COG0583	DNA-binding transcription factor activity
Adeh_2201	COG3118	belongs to the thioredoxin family
Adeh_2202	COG0583	DNA-binding transcription factor activity
Adeh_2205	COG1741	Belongs to the pirin family
Adeh_2207	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Adeh_2209	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Adeh_2210	COG2205	protein histidine kinase activity
Adeh_2212	COG0583	DNA-binding transcription factor activity
Adeh_2213	COG2814	Major facilitator Superfamily
Adeh_2218	COG0004	ammonium transporteR
Adeh_2226	COG0039	L-malate dehydrogenase activity
Adeh_2228	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Adeh_2236	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Adeh_2239	COG2204	response regulator
Adeh_2240	COG4191	Histidine kinase
Adeh_2244	COG2259	Doxx family
Adeh_2250	COG1595	DNA-templated transcription, initiation
Adeh_2251	COG2267	carboxylic ester hydrolase activity
Adeh_2253	COG3604	Transcriptional regulator
Adeh_2255	COG2072	flavoprotein involved in K transport
Adeh_2256	COG0644	oxidoreductase
Adeh_2257	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Adeh_2257	COG0392	lysyltransferase activity
Adeh_2261	COG0443	Heat shock 70 kDa protein
Adeh_2270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Adeh_2273	COG1845	cytochrome c oxidase, subunit III
Adeh_2274	COG1845	cytochrome c oxidase, subunit III
Adeh_2274	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Adeh_2279	COG0737	Belongs to the 5'-nucleotidase family
Adeh_2280	COG2010	Cytochrome c
Adeh_2285	COG4654	Cytochrome c, class I
Adeh_2286	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Adeh_2292	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Adeh_2304	COG0243	molybdopterin cofactor binding
Adeh_2305	COG5322	oxidoreductase activity
Adeh_2305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Adeh_2306	COG0300	oxidoreductase activity
Adeh_2309	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_2309	COG3347	Dehydrogenase
Adeh_2311	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Adeh_2315	COG0436	Aminotransferase
Adeh_2318	COG2985	domain, Protein
Adeh_2318	COG0569	domain protein
Adeh_2324	COG1811	Na channel or pump
Adeh_2327	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Adeh_2329	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Adeh_2338	COG1121	(ABC) transporter
Adeh_2340	COG3746	phosphate-selective porin O and P
Adeh_2342	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Adeh_2344	COG4566	intracellular signal transduction
Adeh_2344	COG0745	RESPONSE REGULATOR receiver
Adeh_2348	COG0519	Catalyzes the synthesis of GMP from XMP
Adeh_2348	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Adeh_2349	COG0516	GMP reductase activity
Adeh_2349	COG0517	IMP dehydrogenase activity
Adeh_2350	COG0443	Heat shock 70 kDa protein
Adeh_2351	COG0586	Pfam SNARE associated Golgi protein
Adeh_2353	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Adeh_2355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Adeh_2357	COG0501	Belongs to the peptidase M48B family
Adeh_2360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Adeh_2364	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Adeh_2365	COG0183	Belongs to the thiolase family
Adeh_2368	COG0330	HflC and HflK could
Adeh_2370	COG1573	uracil-dna glycosylase
Adeh_2376	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Adeh_2378	COG1595	DNA-templated transcription, initiation
Adeh_2387	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Adeh_2388	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Adeh_2388	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Adeh_2390	COG0525	valine-tRNA ligase activity
Adeh_2393	COG3706	GGDEF domain
Adeh_2394	COG0459	protein refolding
Adeh_2396	COG1752	Esterase of the alpha-beta hydrolase superfamily
Adeh_2402	COG4263	nitrous-oxide reductase activity
Adeh_2407	COG0542	response to heat
Adeh_2409	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Adeh_2411	COG3876	Protein conserved in bacteria
Adeh_2415	COG1595	DNA-templated transcription, initiation
Adeh_2418	COG0438	transferase activity, transferring glycosyl groups
Adeh_2422	COG1193	negative regulation of DNA recombination
Adeh_2425	COG0559	Belongs to the binding-protein-dependent transport system permease family
Adeh_2427	COG0411	ABC transporter
Adeh_2429	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Adeh_2430	COG0730	response to heat
Adeh_2432	COG0557	exoribonuclease II activity
Adeh_2434	COG0303	'Molybdopterin
Adeh_2435	COG0745	RESPONSE REGULATOR receiver
Adeh_2437	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Adeh_2438	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Adeh_2443	COG2201	protein-glutamate methylesterase activity
Adeh_2444	COG2205	protein histidine kinase activity
Adeh_2449	COG1181	Belongs to the D-alanine--D-alanine ligase family
Adeh_2452	COG0113	porphobilinogen synthase activity
Adeh_2454	COG0009	L-threonylcarbamoyladenylate synthase
Adeh_2455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Adeh_2458	COG1216	Glycosyl transferase, family 2
Adeh_2468	COG0138	bifunctional purine biosynthesis protein purh
Adeh_2475	COG0312	modulator of DNA gyrase
Adeh_2479	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Adeh_2480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Adeh_2487	COG0587	DNA-directed DNA polymerase activity
Adeh_2489	COG0585	pseudouridine synthase activity
Adeh_2492	COG0181	hydroxymethylbilane synthase activity
Adeh_2493	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Adeh_2496	COG3118	belongs to the thioredoxin family
Adeh_2497	COG0772	Belongs to the SEDS family
Adeh_2498	COG0768	penicillin binding
Adeh_2501	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Adeh_2502	COG0424	maF-like protein
Adeh_2503	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Adeh_2510	COG1830	Aldolase
Adeh_2512	COG1074	ATP-dependent DNA helicase activity
Adeh_2516	COG0352	thiamine-phosphate diphosphorylase activity
Adeh_2518	COG2022	thiamine diphosphate biosynthetic process
Adeh_2523	COG0612	Peptidase, M16
Adeh_2524	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Adeh_2527	COG1597	lipid kinase activity
Adeh_2532	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Adeh_2533	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Adeh_2535	COG0604	alcohol dehydrogenase
Adeh_2536	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Adeh_2536	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Adeh_2539	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Adeh_2540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Adeh_2541	COG1862	Preprotein translocase
Adeh_2542	COG0343	queuine tRNA-ribosyltransferase activity
Adeh_2544	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Adeh_2545	COG2385	sporulation resulting in formation of a cellular spore
Adeh_2546	COG0586	Pfam SNARE associated Golgi protein
Adeh_2552	COG0011	TIGRFAM Protein of
Adeh_2553	COG1716	ATPase activity
Adeh_2554	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Adeh_2558	COG0521	Mo-molybdopterin cofactor biosynthetic process
Adeh_2560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Adeh_2560	COG1796	DNA polymerase
Adeh_2561	COG2223	nitrite transmembrane transporter activity
Adeh_2564	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Adeh_2567	COG0649	NAD binding
Adeh_2568	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2569	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2571	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2572	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2573	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2574	COG0649	NAD binding
Adeh_2575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Adeh_2576	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_2578	COG0713	ATP synthesis coupled electron transport
Adeh_2581	COG1007	ATP synthesis coupled electron transport
Adeh_2582	COG0613	PHP domain protein
Adeh_2583	COG1959	2 iron, 2 sulfur cluster binding
Adeh_2584	COG0010	Belongs to the arginase family
Adeh_2585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Adeh_2587	COG0484	heat shock protein binding
Adeh_2588	COG0443	Heat shock 70 kDa protein
Adeh_2590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Adeh_2594	COG1355	regulation of microtubule-based process
Adeh_2597	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Adeh_2599	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Adeh_2602	COG0114	fumarate hydratase activity
Adeh_2606	COG0194	GDP metabolic process
Adeh_2607	COG1561	YicC-like family, N-terminal region
Adeh_2608	COG2835	tetraacyldisaccharide 4'-kinase activity
Adeh_2610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Adeh_2610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Adeh_2612	COG1560	Kdo2-lipid A biosynthetic process
Adeh_2613	COG1663	tetraacyldisaccharide 4'-kinase activity
Adeh_2614	COG0859	PFAM glycosyl transferase family 9
Adeh_2615	COG1519	Transferase
Adeh_2617	COG1132	(ABC) transporter
Adeh_2618	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Adeh_2619	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Adeh_2622	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Adeh_2623	COG2095	MarC family integral membrane protein
Adeh_2624	COG0463	Glycosyl transferase, family 2
Adeh_2625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Adeh_2631	COG0437	4 iron, 4 sulfur cluster binding
Adeh_2632	COG0243	molybdopterin cofactor binding
Adeh_2635	COG0745	RESPONSE REGULATOR receiver
Adeh_2637	COG1053	succinate dehydrogenase
Adeh_2639	COG0438	transferase activity, transferring glycosyl groups
Adeh_2646	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Adeh_2647	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Adeh_2648	COG0489	protein tyrosine kinase activity
Adeh_2651	COG2204	response regulator
Adeh_2654	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Adeh_2656	COG1136	(ABC) transporter
Adeh_2667	COG0492	ferredoxin-NADP+ reductase activity
Adeh_2672	COG2169	Transcriptional regulator
Adeh_2676	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Adeh_2681	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Adeh_2684	COG0237	dephospho-CoA kinase activity
Adeh_2689	COG0443	Heat shock 70 kDa protein
Adeh_2691	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Adeh_2692	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Adeh_2693	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Adeh_2694	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Adeh_2697	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Adeh_2699	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Adeh_2701	COG1652	LysM domain
Adeh_2704	COG5001	Diguanylate cyclase
Adeh_2704	COG2203	Gaf domain
Adeh_2704	COG3706	GGDEF domain
Adeh_2704	COG4251	negative regulation of phosphorylation
Adeh_2705	COG1196	nuclear chromosome segregation
Adeh_2705	COG0745	RESPONSE REGULATOR receiver
Adeh_2707	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Adeh_2710	COG0438	transferase activity, transferring glycosyl groups
Adeh_2713	COG4932	domain protein
Adeh_2713	COG5492	domain, Protein
Adeh_2716	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Adeh_2717	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Adeh_2719	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Adeh_2720	COG1480	7TM receptor with intracellular HD hydrolase
Adeh_2722	COG0457	Tetratricopeptide repeat
Adeh_2724	COG3956	TIGRFAM MazG family protein
Adeh_2725	COG0268	Binds directly to 16S ribosomal RNA
Adeh_2727	COG0495	leucyl-tRNA aminoacylation
Adeh_2728	COG0017	Asparaginyl-tRNA synthetase
Adeh_2730	COG2201	protein-glutamate methylesterase activity
Adeh_2733	COG0835	chemotaxis
Adeh_2735	COG3267	Type II secretory pathway component ExeA
Adeh_2735	COG3409	Peptidoglycan-binding domain 1 protein
Adeh_2736	COG0643	Histidine kinase
Adeh_2736	COG2198	Histidine kinase
Adeh_2739	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Adeh_2740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Adeh_2740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Adeh_2742	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Adeh_2742	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Adeh_2743	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Adeh_2744	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Adeh_2745	COG0698	ribose 5-phosphate isomerase
Adeh_2747	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Adeh_2749	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Adeh_2750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Adeh_2751	COG0416	fatty acid biosynthetic process
Adeh_2752	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Adeh_2759	COG2827	Endonuclease containing a URI domain
Adeh_2760	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_2764	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Adeh_2765	COG0438	transferase activity, transferring glycosyl groups
Adeh_2766	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Adeh_2771	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Adeh_2775	COG1215	transferase activity, transferring glycosyl groups
Adeh_2780	COG0367	asparagine synthase
Adeh_2783	COG1696	Membrane protein involved in D-alanine export
Adeh_2785	COG0318	PFAM AMP-dependent synthetase and ligase
Adeh_2788	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Adeh_2789	COG0367	asparagine synthase
Adeh_2791	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Adeh_2791	COG0493	'glutamate synthase
Adeh_2796	COG0515	serine threonine protein kinase
Adeh_2796	COG2815	serine threonine protein kinase
Adeh_2800	COG3186	Phenylalanine-4-hydroxylase
Adeh_2801	COG0488	(ABC) transporter
Adeh_2803	COG0745	RESPONSE REGULATOR receiver
Adeh_2805	COG2205	protein histidine kinase activity
Adeh_2805	COG2198	Histidine kinase
Adeh_2805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Adeh_2805	COG0784	Response regulator, receiver
Adeh_2810	COG2801	Transposase and inactivated derivatives
Adeh_2818	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_2826	COG2894	cell division
Adeh_2827	COG4964	Belongs to the GSP D family
Adeh_2843	COG0604	alcohol dehydrogenase
Adeh_2846	COG0450	alkyl hydroperoxide reductase
Adeh_2848	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Adeh_2851	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Adeh_2852	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Adeh_2853	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Adeh_2861	COG1301	dicarboxylic acid transport
Adeh_2863	COG0071	Belongs to the small heat shock protein (HSP20) family
Adeh_2865	COG0247	lactate metabolic process
Adeh_2866	COG0277	FAD linked oxidase domain protein
Adeh_2867	COG0277	FAD linked oxidase domain protein
Adeh_2879	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Adeh_2886	COG1022	Amp-dependent synthetase and ligase
Adeh_2890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Adeh_2892	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Adeh_2893	COG0406	alpha-ribazole phosphatase activity
Adeh_2895	COG1032	radical SAM domain protein
Adeh_2897	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Adeh_2898	COG0702	epimerase
Adeh_2902	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Adeh_2904	COG0318	PFAM AMP-dependent synthetase and ligase
Adeh_2905	COG0671	phosphoesterase, PA-phosphatase related
Adeh_2911	COG1388	LysM domain
Adeh_2911	COG1376	ErfK ybiS ycfS ynhG family protein
Adeh_2914	COG0745	RESPONSE REGULATOR receiver
Adeh_2915	COG2205	protein histidine kinase activity
Adeh_2925	COG1215	transferase activity, transferring glycosyl groups
Adeh_2926	COG0726	polysaccharide deacetylase
Adeh_2926	COG1649	PFAM Uncharacterised BCR, COG1649
Adeh_2928	COG4968	Prepilin-type N-terminal cleavage methylation domain
Adeh_2933	COG1053	succinate dehydrogenase
Adeh_2937	COG1404	Belongs to the peptidase S8 family
Adeh_2937	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Adeh_2942	COG5002	protein histidine kinase activity
Adeh_2943	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Adeh_2943	COG2205	protein histidine kinase activity
Adeh_2944	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Adeh_2954	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Adeh_2955	COG0513	Belongs to the DEAD box helicase family
Adeh_2956	COG2205	protein histidine kinase activity
Adeh_2956	COG2202	Pas domain
Adeh_2958	COG2271	Major facilitator Superfamily
Adeh_2960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Adeh_2963	COG0484	heat shock protein binding
Adeh_2970	COG1136	(ABC) transporter
Adeh_2970	COG0577	efflux transmembrane transporter activity
Adeh_2971	COG4591	ABC-type transport system involved in lipoprotein release permease component
Adeh_2971	COG1136	(ABC) transporter
Adeh_2972	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeh_2974	COG1620	l-lactate permease
Adeh_2976	COG1139	Iron-sulfur cluster binding protein
Adeh_2979	COG4106	trans-aconitate 2-methyltransferase activity
Adeh_2983	COG2264	protein methyltransferase activity
Adeh_2993	COG4106	trans-aconitate 2-methyltransferase activity
Adeh_2994	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Adeh_2995	COG0745	RESPONSE REGULATOR receiver
Adeh_2997	COG3800	Transcriptional regulator
Adeh_2997	COG1396	sequence-specific DNA binding
Adeh_2998	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Adeh_3002	COG0366	Alpha amylase catalytic
Adeh_3005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Adeh_3006	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Adeh_3007	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Adeh_3009	COG0318	PFAM AMP-dependent synthetase and ligase
Adeh_3012	COG1013	pyruvate-flavodoxin oxidoreductase activity
Adeh_3013	COG0674	pyruvate-flavodoxin oxidoreductase activity
Adeh_3013	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Adeh_3015	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Adeh_3018	COG0277	FAD linked oxidase domain protein
Adeh_3019	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Adeh_3024	COG1960	acyl-CoA dehydrogenase activity
Adeh_3027	COG0702	epimerase
Adeh_3029	COG3272	Protein of unknown function (DUF1722)
Adeh_3031	COG1295	ribonuclease BN
Adeh_3033	COG0443	Heat shock 70 kDa protein
Adeh_3036	COG0667	Aldo Keto reductase
Adeh_3037	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Adeh_3040	COG0667	Aldo Keto reductase
Adeh_3041	COG0693	protein deglycase activity
Adeh_3049	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Adeh_3050	COG1216	Glycosyl transferase, family 2
Adeh_3051	COG1216	Glycosyl transferase, family 2
Adeh_3057	COG0438	transferase activity, transferring glycosyl groups
Adeh_3061	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Adeh_3062	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Adeh_3080	COG0166	Belongs to the GPI family
Adeh_3084	COG0840	transmembrane signaling receptor activity
Adeh_3085	COG0137	argininosuccinate synthase activity
Adeh_3091	COG2204	response regulator
Adeh_3095	COG0702	epimerase
Adeh_3096	COG0667	Aldo Keto reductase
Adeh_3098	COG0308	aminopeptidase N
Adeh_3099	COG1309	transcriptional regulator
Adeh_3104	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Adeh_3104	COG3608	succinylglutamate desuccinylase aspartoacylase
Adeh_3107	COG0737	Belongs to the 5'-nucleotidase family
Adeh_3108	COG0339	signal peptide processing
Adeh_3109	COG3852	Histidine kinase
Adeh_3111	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeh_3112	COG1131	(ABC) transporter
Adeh_3113	COG1131	(ABC) transporter
Adeh_3114	COG0842	Transport permease protein
Adeh_3115	COG0842	Transport permease protein
Adeh_3116	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Adeh_3117	COG2329	Antibiotic biosynthesis monooxygenase
Adeh_3118	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Adeh_3118	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Adeh_3120	COG3842	ATPase activity
Adeh_3128	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Adeh_3129	COG1595	DNA-templated transcription, initiation
Adeh_3130	COG0583	DNA-binding transcription factor activity
Adeh_3133	COG1162	GTPase activity
Adeh_3136	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Adeh_3137	COG1127	ABC transporter
Adeh_3140	COG1309	transcriptional regulator
Adeh_3141	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_3146	COG0723	plastoquinol--plastocyanin reductase activity
Adeh_3152	COG2855	membrane
Adeh_3160	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_3165	COG3483	tryptophan 2,3-dioxygenase activity
Adeh_3166	COG1064	alcohol dehydrogenase
Adeh_3169	COG1131	(ABC) transporter
Adeh_3170	COG0025	NhaP-type Na H and K H
Adeh_3172	COG1473	amidohydrolase
Adeh_3173	COG2860	membrane
Adeh_3174	COG2130	NADP-dependent
Adeh_3176	COG1278	Cold shock
Adeh_3177	COG0508	dehydrogenase complex catalyzes the overall conversion of
Adeh_3177	COG0596	Alpha beta hydrolase
Adeh_3179	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Adeh_3180	COG0784	Response regulator, receiver
Adeh_3180	COG2205	protein histidine kinase activity
Adeh_3181	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Adeh_3184	COG3459	Glycosyltransferase 36 associated
Adeh_3188	COG1404	Belongs to the peptidase S8 family
Adeh_3193	COG3387	PFAM Glycoside hydrolase 15-related
Adeh_3199	COG3604	Transcriptional regulator
Adeh_3203	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Adeh_3204	COG0583	DNA-binding transcription factor activity
Adeh_3205	COG4221	oxidoreductase activity
Adeh_3206	COG4221	oxidoreductase activity
Adeh_3210	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
Adeh_3213	COG1073	alpha beta
Adeh_3214	COG0667	Aldo Keto reductase
Adeh_3215	COG0667	Aldo Keto reductase
Adeh_3216	COG0702	epimerase
Adeh_3217	COG4221	oxidoreductase activity
Adeh_3219	COG0583	DNA-binding transcription factor activity
Adeh_3223	COG0210	DNA helicase
Adeh_3224	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Adeh_3230	COG1196	nuclear chromosome segregation
Adeh_3240	COG0358	DNA primase activity
Adeh_3262	COG2003	Belongs to the UPF0758 family
Adeh_3266	COG0714	Associated with various cellular activities
Adeh_3268	COG1475	DNA binding
Adeh_3274	COG1192	Involved in chromosome partitioning
Adeh_3276	COG0741	lytic transglycosylase activity
Adeh_3287	COG0006	proline dipeptidase activity
Adeh_3293	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Adeh_3293	COG1918	ferrous iron import across plasma membrane
Adeh_3294	COG0604	alcohol dehydrogenase
Adeh_3298	COG0516	GMP reductase activity
Adeh_3299	COG2132	Multicopper oxidase
Adeh_3300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Adeh_3304	COG1704	LemA family
Adeh_3305	COG0501	Belongs to the peptidase M48B family
Adeh_3307	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Adeh_3313	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Adeh_3317	COG5337	Spore coat protein CotH
Adeh_3331	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Adeh_3338	COG2204	response regulator
Adeh_3342	COG5000	phosphorelay sensor kinase activity
Adeh_3345	COG2252	PERMEase
Adeh_3346	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Adeh_3348	COG2521	methyltransferase
Adeh_3348	COG2136	Putative SAM-dependent methyltransferase
Adeh_3351	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Adeh_3351	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Adeh_3354	COG0544	peptidyl-prolyl cis-trans isomerase activity
Adeh_3356	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Adeh_3358	COG0463	Glycosyl transferase, family 2
Adeh_3360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Adeh_3361	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Adeh_3363	COG0709	Synthesizes selenophosphate from selenide and ATP
Adeh_3366	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Adeh_3370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Adeh_3372	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Adeh_3374	COG0210	DNA helicase
Adeh_3379	COG0564	pseudouridine synthase activity
Adeh_3380	COG0625	glutathione transferase activity
Adeh_3381	COG0612	Peptidase, M16
Adeh_3383	COG4191	Histidine kinase
Adeh_3385	COG1129	ABC transporter
Adeh_3386	COG0739	heme binding
Adeh_3387	COG0483	inositol monophosphate 1-phosphatase activity
Adeh_3390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Adeh_3393	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Adeh_3395	COG1619	proteins homologs of microcin C7 resistance protein MccF
Adeh_3396	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Adeh_3397	COG0628	permease
Adeh_3398	COG0545	Peptidyl-prolyl cis-trans isomerase
Adeh_3409	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Adeh_3410	COG1136	(ABC) transporter
Adeh_3411	COG4591	ABC-type transport system involved in lipoprotein release permease component
Adeh_3412	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeh_3414	COG0189	ligase activity
Adeh_3422	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Adeh_3427	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Adeh_3428	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Adeh_3429	COG1846	Transcriptional regulator
Adeh_3434	COG0471	metal ion transport
Adeh_3434	COG3273	potassium ion transport
Adeh_3438	COG0123	including yeast histone deacetylase and acetoin utilization protein
Adeh_3442	COG0270	DNA (cytosine-5-)-methyltransferase activity
Adeh_3445	COG0587	DNA-directed DNA polymerase activity
Adeh_3446	COG0730	response to heat
Adeh_3447	COG2197	response regulator
Adeh_3448	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Adeh_3452	COG0156	8-amino-7-oxononanoate synthase activity
Adeh_3453	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Adeh_3455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Adeh_3457	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Adeh_3462	COG4206	TonB-dependent receptor
Adeh_3464	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Adeh_3465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Adeh_3466	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Adeh_3469	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Adeh_3472	COG4191	Histidine kinase
Adeh_3473	COG0745	RESPONSE REGULATOR receiver
Adeh_3473	COG3706	GGDEF domain
Adeh_3476	COG2096	Adenosyltransferase
Adeh_3479	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Adeh_3480	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Adeh_3483	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Adeh_3487	COG2226	methyltransferase
Adeh_3488	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Adeh_3489	COG1741	Belongs to the pirin family
Adeh_3495	COG1937	Protein conserved in bacteria
Adeh_3496	COG2217	Heavy metal translocating P-type atpase
Adeh_3499	COG4941	Belongs to the sigma-70 factor family
Adeh_3500	COG3795	YCII-related domain
Adeh_3504	COG0438	transferase activity, transferring glycosyl groups
Adeh_3505	COG0667	Aldo Keto reductase
Adeh_3506	COG0583	DNA-binding transcription factor activity
Adeh_3508	COG3118	belongs to the thioredoxin family
Adeh_3513	COG0840	transmembrane signaling receptor activity
Adeh_3514	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Adeh_3518	COG0745	RESPONSE REGULATOR receiver
Adeh_3523	COG0330	HflC and HflK could
Adeh_3524	COG1404	Belongs to the peptidase S8 family
Adeh_3527	COG1063	alcohol dehydrogenase
Adeh_3529	COG3447	MASE1 domain protein
Adeh_3529	COG5001	Diguanylate cyclase
Adeh_3529	COG5002	protein histidine kinase activity
Adeh_3532	COG2205	protein histidine kinase activity
Adeh_3536	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
Adeh_3544	COG1715	Restriction endonuclease
Adeh_3561	COG4974	Belongs to the 'phage' integrase family
Adeh_3563	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Adeh_3565	COG0739	heme binding
Adeh_3565	COG1196	nuclear chromosome segregation
Adeh_3565	COG0741	lytic transglycosylase activity
Adeh_3566	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Adeh_3568	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Adeh_3575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Adeh_3578	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Adeh_3579	COG1090	epimerase
Adeh_3582	COG0750	zinc metalloprotease
Adeh_3585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Adeh_3593	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Adeh_3594	COG0459	protein refolding
Adeh_3605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Adeh_3611	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Adeh_3612	COG1183	phosphatidylcholine synthase activity
Adeh_3613	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Adeh_3614	COG1546	Belongs to the CinA family
Adeh_3614	COG1058	Belongs to the CinA family
Adeh_3633	COG1100	Small GTP-binding protein
Adeh_3635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Adeh_3636	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Adeh_3637	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Adeh_3638	COG0590	tRNA wobble adenosine to inosine editing
Adeh_3641	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Adeh_3641	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Adeh_3643	COG0585	pseudouridine synthase activity
Adeh_3651	COG2204	response regulator
Adeh_3654	COG0651	ATP synthesis coupled electron transport
Adeh_3655	COG0651	ATP synthesis coupled electron transport
Adeh_3658	COG0651	ATP synthesis coupled electron transport
Adeh_3659	COG0649	NAD binding
Adeh_3660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Adeh_3664	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Adeh_3665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Adeh_3668	COG0475	glutathione-regulated potassium exporter activity
Adeh_3671	COG0739	heme binding
Adeh_3673	COG0539	negative regulation of cytoplasmic translation
Adeh_3676	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Adeh_3680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Adeh_3681	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Adeh_3682	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Adeh_3683	COG1428	Deoxynucleoside kinase
Adeh_3685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Adeh_3687	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Adeh_3688	COG0745	RESPONSE REGULATOR receiver
Adeh_3688	COG3706	GGDEF domain
Adeh_3689	COG0484	heat shock protein binding
Adeh_3691	COG0631	protein serine/threonine phosphatase activity
Adeh_3692	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Adeh_3696	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Adeh_3698	COG0477	Major facilitator Superfamily
Adeh_3703	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Adeh_3704	COG0840	transmembrane signaling receptor activity
Adeh_3707	COG0626	cystathionine gamma-synthase activity
Adeh_3710	COG0477	Major facilitator Superfamily
Adeh_3716	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Adeh_3718	COG0840	transmembrane signaling receptor activity
Adeh_3719	COG1902	pentaerythritol trinitrate reductase activity
Adeh_3721	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Adeh_3722	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Adeh_3724	COG5002	protein histidine kinase activity
Adeh_3728	COG3852	Histidine kinase
Adeh_3729	COG2204	response regulator
Adeh_3730	COG1271	oxidase subunit
Adeh_3731	COG1294	oxidase, subunit
Adeh_3733	COG2226	methyltransferase
Adeh_3740	COG0515	serine threonine protein kinase
Adeh_3742	COG1024	Enoyl-CoA hydratase
Adeh_3743	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Adeh_3748	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Adeh_3750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Adeh_3753	COG3383	formate dehydrogenase (NAD+) activity
Adeh_3753	COG0243	molybdopterin cofactor binding
Adeh_3754	COG0243	molybdopterin cofactor binding
Adeh_3754	COG3383	formate dehydrogenase (NAD+) activity
Adeh_3755	COG0437	4 iron, 4 sulfur cluster binding
Adeh_3756	COG2864	formate dehydrogenase
Adeh_3760	COG1028	Short-chain dehydrogenase reductase Sdr
Adeh_3763	COG0275	rRNA processing
Adeh_3766	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Adeh_3767	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Adeh_3769	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Adeh_3771	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Adeh_3772	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Adeh_3773	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Adeh_3774	COG1181	Belongs to the D-alanine--D-alanine ligase family
Adeh_3778	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Adeh_3784	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Adeh_3785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Adeh_3787	COG1136	(ABC) transporter
Adeh_3787	COG0577	efflux transmembrane transporter activity
Adeh_3789	COG1388	LysM domain
Adeh_3789	COG1705	Flagellar rod assembly protein muramidase FlgJ
Adeh_3791	COG2204	response regulator
Adeh_3796	COG0793	Belongs to the peptidase S41A family
Adeh_3799	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Adeh_3807	COG2027	D-alanyl-D-alanine carboxypeptidase
Adeh_3808	COG0629	single-stranded DNA binding
Adeh_3812	COG0640	Transcriptional regulator
Adeh_3819	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Adeh_3824	COG2003	Belongs to the UPF0758 family
Adeh_3826	COG2353	YceI-like domain
Adeh_3828	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Adeh_3829	COG2171	N-acyltransferase activity
Adeh_3835	COG1192	Involved in chromosome partitioning
Adeh_3840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Adeh_3841	COG0047	phosphoribosylformylglycinamidine synthase activity
Adeh_3845	COG0312	modulator of DNA gyrase
Adeh_3846	COG0312	modulator of DNA gyrase
Adeh_3849	COG4221	oxidoreductase activity
Adeh_3853	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Adeh_3855	COG2205	protein histidine kinase activity
Adeh_3856	COG0745	RESPONSE REGULATOR receiver
Adeh_3864	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Adeh_3869	COG1061	Type III restriction enzyme res subunit
Adeh_3878	COG1074	ATP-dependent DNA helicase activity
Adeh_3880	COG0653	protein targeting
Adeh_3883	COG1032	radical SAM domain protein
Adeh_3891	COG0745	RESPONSE REGULATOR receiver
Adeh_3897	COG0840	transmembrane signaling receptor activity
Adeh_3900	COG0604	alcohol dehydrogenase
Adeh_3900	COG3321	synthase
Adeh_3902	COG2378	regulation of single-species biofilm formation
Adeh_3907	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Adeh_3910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Adeh_3917	COG0488	(ABC) transporter
Adeh_3924	COG1322	Protein conserved in bacteria
Adeh_3928	COG0154	amidase activity
Adeh_3929	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Adeh_3930	COG0281	malic enzyme
Adeh_3930	COG0280	phosphate acetyltransferase
Adeh_3933	COG1252	NADH dehydrogenase
Adeh_3937	COG0577	efflux transmembrane transporter activity
Adeh_3937	COG1136	(ABC) transporter
Adeh_3939	COG1136	(ABC) transporter
Adeh_3940	COG2840	Smr protein MutS2
Adeh_3943	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Adeh_3944	COG2239	Acts as a magnesium transporter
Adeh_3945	COG0284	orotidine-5'-phosphate decarboxylase activity
Adeh_3947	COG0442	prolyl-tRNA aminoacylation
Adeh_3949	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Adeh_3950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Adeh_3950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Adeh_3951	COG0492	ferredoxin-NADP+ reductase activity
Adeh_3952	COG0315	cyclic pyranopterin monophosphate synthase activity
Adeh_3957	COG0405	Gamma-glutamyltransferase
Adeh_3958	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Adeh_3959	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Adeh_3960	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Adeh_3962	COG1678	Uncharacterized ACR, COG1678
Adeh_3968	COG2379	hydroxypyruvate reductase
Adeh_3969	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Adeh_3971	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Adeh_3972	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Adeh_3976	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Adeh_3977	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Adeh_3983	COG0670	Belongs to the BI1 family
Adeh_3985	COG0584	glycerophosphoryl diester phosphodiesterase
Adeh_3988	COG0488	(ABC) transporter
Adeh_3989	COG2814	Major facilitator Superfamily
Adeh_3998	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Adeh_3999	COG3647	Membrane
Adeh_4002	COG0704	Plays a role in the regulation of phosphate uptake
Adeh_4003	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Adeh_4004	COG0581	inorganic phosphate transmembrane transporter activity
Adeh_4005	COG0573	inorganic phosphate transmembrane transporter activity
Adeh_4006	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Adeh_4008	COG5002	protein histidine kinase activity
Adeh_4012	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Adeh_4012	COG0116	Belongs to the methyltransferase superfamily
Adeh_4017	COG2814	Major facilitator Superfamily
Adeh_4021	COG3104	oligopeptide transport
Adeh_4022	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Adeh_4023	COG2363	Small membrane protein
Adeh_4024	COG2154	pterin-4-alpha-carbinolamine dehydratase
Adeh_4026	COG1408	metallophosphoesterase
Adeh_4031	COG2967	ApaG domain
Adeh_4034	COG0811	peptide transport
Adeh_4038	COG2030	dehydratase
Adeh_4040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Adeh_4044	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Adeh_4044	COG0574	Belongs to the PEP-utilizing enzyme family
Adeh_4046	COG0425	Belongs to the sulfur carrier protein TusA family
Adeh_4049	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Adeh_4049	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Adeh_4051	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Adeh_4052	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Adeh_4054	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Adeh_4055	COG0134	indole-3-glycerol-phosphate synthase activity
Adeh_4056	COG0135	phosphoribosylanthranilate isomerase activity
Adeh_4057	COG0133	tryptophan synthase activity
Adeh_4058	COG0159	tryptophan synthase activity
Adeh_4059	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Adeh_4063	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Adeh_4064	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Adeh_4064	COG0517	IMP dehydrogenase activity
Adeh_4065	COG0235	Class ii aldolase
Adeh_4066	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Adeh_4067	COG0179	Fumarylacetoacetate (FAA) hydrolase
Adeh_4068	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Adeh_4069	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Adeh_4070	COG0019	diaminopimelate decarboxylase activity
Adeh_4071	COG0165	Argininosuccinate lyase
Adeh_4074	COG0346	lactoylglutathione lyase activity
Adeh_4076	COG2715	membrane protein required for spore maturation
Adeh_4077	COG0700	Nucleoside recognition
Adeh_4086	COG0297	glycogen (starch) synthase activity
Adeh_4094	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Adeh_4095	COG0438	transferase activity, transferring glycosyl groups
Adeh_4097	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Adeh_4099	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Adeh_4103	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Adeh_4104	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Adeh_4105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeh_4111	COG0129	dihydroxy-acid dehydratase activity
Adeh_4116	COG0745	RESPONSE REGULATOR receiver
Adeh_4118	COG1960	acyl-CoA dehydrogenase activity
Adeh_4122	COG0784	Response regulator, receiver
Adeh_4122	COG2198	Histidine kinase
Adeh_4122	COG5002	protein histidine kinase activity
Adeh_4132	COG4580	involved in the transport of maltose and maltodextrins
Adeh_4134	COG3833	ABC-type maltose transport systems, permease component
Adeh_4135	COG1175	transmembrane transport
Adeh_4138	COG0366	Alpha amylase catalytic
Adeh_4147	COG0438	transferase activity, transferring glycosyl groups
Adeh_4154	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Adeh_4155	COG0577	efflux transmembrane transporter activity
Adeh_4155	COG1136	(ABC) transporter
Adeh_4156	COG1136	(ABC) transporter
Adeh_4156	COG0577	efflux transmembrane transporter activity
Adeh_4157	COG0577	efflux transmembrane transporter activity
Adeh_4157	COG1136	(ABC) transporter
Adeh_4158	COG0681	Belongs to the peptidase S26 family
Adeh_4160	COG1793	dna ligase
Adeh_4162	COG3259	Nickel-dependent hydrogenase
Adeh_4165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Adeh_4165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Adeh_4165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Adeh_4166	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Adeh_4171	COG1560	Kdo2-lipid A biosynthetic process
Adeh_4172	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Adeh_4173	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Adeh_4174	COG0504	CTP synthase activity
Adeh_4175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Adeh_4177	COG0564	pseudouridine synthase activity
Adeh_4179	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Adeh_4180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Adeh_4182	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Adeh_4184	COG3339	Conserved Protein
Adeh_4186	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Adeh_4187	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Adeh_4188	COG0154	amidase activity
Adeh_4189	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Adeh_4191	COG0457	Tetratricopeptide repeat
Adeh_4192	COG1674	ftsk spoiiie
Adeh_4193	COG2885	chlorophyll binding
Adeh_4193	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Adeh_4194	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Adeh_4197	COG0713	ATP synthesis coupled electron transport
Adeh_4198	COG0839	Belongs to the complex I subunit 6 family
Adeh_4201	COG0784	Response regulator, receiver
Adeh_4201	COG2205	protein histidine kinase activity
Adeh_4202	COG2153	protein acetylation
Adeh_4206	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Adeh_4213	COG2205	protein histidine kinase activity
Adeh_4213	COG0784	Response regulator, receiver
Adeh_4214	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Adeh_4219	COG1193	negative regulation of DNA recombination
Adeh_4220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Adeh_4226	COG5002	protein histidine kinase activity
Adeh_4228	COG0306	phosphate transporter
Adeh_4229	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Adeh_4231	COG2094	Belongs to the DNA glycosylase MPG family
Adeh_4236	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Adeh_4240	COG2204	response regulator
Adeh_4242	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Adeh_4246	COG3852	Histidine kinase
Adeh_4252	COG0174	glutamine synthetase
Adeh_4254	COG2076	Multidrug Resistance protein
Adeh_4258	COG0411	ABC transporter
Adeh_4260	COG0559	Belongs to the binding-protein-dependent transport system permease family
Adeh_4262	COG0745	RESPONSE REGULATOR receiver
Adeh_4264	COG1472	Belongs to the glycosyl hydrolase 3 family
Adeh_4267	COG2827	Endonuclease containing a URI domain
Adeh_4268	COG0714	Associated with various cellular activities
Adeh_4275	COG1596	polysaccharide export
Adeh_4277	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Adeh_4286	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Adeh_4287	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Adeh_4293	COG0463	Glycosyl transferase, family 2
Adeh_4297	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Adeh_4298	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Adeh_4302	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Adeh_4306	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Adeh_4307	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Adeh_4312	COG3852	Histidine kinase
Adeh_4313	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Adeh_4314	COG1691	(AIR) carboxylase
Adeh_4316	COG0643	Histidine kinase
Adeh_4316	COG2198	Histidine kinase
Adeh_4317	COG2201	protein-glutamate methylesterase activity
Adeh_4319	COG0840	transmembrane signaling receptor activity
Adeh_4319	COG3290	protein histidine kinase activity
Adeh_4320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Adeh_4321	COG2205	protein histidine kinase activity
Adeh_4321	COG2202	Pas domain
Adeh_4322	COG1100	Small GTP-binding protein
Adeh_4323	COG1199	ATP-dependent helicase activity
Adeh_4327	COG0484	heat shock protein binding
Adeh_4328	COG0443	Heat shock 70 kDa protein
Adeh_4329	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Adeh_4330	COG1420	regulation of RNA biosynthetic process
Adeh_4334	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Adeh_4335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Adeh_4336	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Adeh_4337	COG0012	GTP binding
Adeh_4338	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Adeh_4339	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Adeh_4340	COG0356	it plays a direct role in the translocation of protons across the membrane
Adeh_4344	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Adeh_4347	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Adeh_4348	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Adeh_4349	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Adeh_4350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Adeh_4351	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Adeh_4352	COG0071	Belongs to the small heat shock protein (HSP20) family
Adeh_4354	COG1475	DNA binding
Adeh_4355	COG1192	Involved in chromosome partitioning
Adeh_4356	COG0357	Ribosomal RNA small subunit methyltransferase G
Adeh_4358	COG0706	membrane insertase activity
Adeh_4359	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Adeh_4360	COG0594	ribonuclease P activity