locus-tag	class	description
Anae109_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Anae109_0002	COG0592	DNA-directed DNA polymerase activity
Anae109_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Anae109_0005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Anae109_0008	COG0596	Alpha beta hydrolase
Anae109_0009	COG2181	nitrate reductase activity
Anae109_0009	COG0247	lactate metabolic process
Anae109_0012	COG0189	ligase activity
Anae109_0013	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Anae109_0014	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Anae109_0015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Anae109_0019	COG2885	chlorophyll binding
Anae109_0019	COG3047	cAMP biosynthetic process
Anae109_0027	COG2205	protein histidine kinase activity
Anae109_0031	COG0477	Major facilitator Superfamily
Anae109_0032	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_0035	COG2067	long-chain fatty acid transport protein
Anae109_0036	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Anae109_0039	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Anae109_0041	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Anae109_0044	COG0280	phosphate acetyltransferase
Anae109_0045	COG3426	butyrate kinase activity
Anae109_0049	COG2086	electron transfer activity
Anae109_0051	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Anae109_0052	COG0861	Integral membrane protein TerC family
Anae109_0054	COG0297	glycogen (starch) synthase activity
Anae109_0055	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Anae109_0056	COG2233	PERMEase
Anae109_0057	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Anae109_0057	COG1793	dna ligase
Anae109_0059	COG0564	pseudouridine synthase activity
Anae109_0063	COG0805	protein transport
Anae109_0064	COG0183	Belongs to the thiolase family
Anae109_0070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Anae109_0071	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Anae109_0073	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anae109_0075	COG0352	thiamine-phosphate diphosphorylase activity
Anae109_0076	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Anae109_0077	COG0351	phosphomethylpyrimidine kinase
Anae109_0077	COG0352	thiamine-phosphate diphosphorylase activity
Anae109_0077	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Anae109_0078	COG0305	Participates in initiation and elongation during chromosome replication
Anae109_0080	COG2239	Acts as a magnesium transporter
Anae109_0081	COG0612	Peptidase, M16
Anae109_0087	COG1410	methionine synthase
Anae109_0087	COG0646	methionine synthase
Anae109_0091	COG0433	COG0433 Predicted ATPase
Anae109_0092	COG0463	Glycosyl transferase, family 2
Anae109_0094	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anae109_0095	COG1666	GTP binding
Anae109_0096	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Anae109_0098	COG0210	DNA helicase
Anae109_0100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Anae109_0101	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Anae109_0102	COG0745	RESPONSE REGULATOR receiver
Anae109_0102	COG3706	GGDEF domain
Anae109_0106	COG2205	protein histidine kinase activity
Anae109_0110	COG2204	response regulator
Anae109_0111	COG3852	Histidine kinase
Anae109_0117	COG1077	Cell shape determining protein MreB Mrl
Anae109_0118	COG0823	Involved in the tonB-independent uptake of proteins
Anae109_0118	COG1506	peptidase
Anae109_0120	COG0359	binds to the 23S rRNA
Anae109_0121	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Anae109_0122	COG0360	Binds together with S18 to 16S ribosomal RNA
Anae109_0123	COG0193	aminoacyl-tRNA hydrolase activity
Anae109_0124	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Anae109_0125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Anae109_0126	COG2088	sporulation resulting in formation of a cellular spore
Anae109_0127	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Anae109_0130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Anae109_0131	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Anae109_0136	COG3706	GGDEF domain
Anae109_0139	COG0297	glycogen (starch) synthase activity
Anae109_0149	COG2204	response regulator
Anae109_0151	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Anae109_0152	COG1660	Displays ATPase and GTPase activities
Anae109_0153	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Anae109_0153	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Anae109_0156	COG3716	PTS system mannose fructose sorbose family IID component
Anae109_0158	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Anae109_0159	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Anae109_0160	COG2226	methyltransferase
Anae109_0161	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Anae109_0163	COG1968	undecaprenyl-diphosphatase activity
Anae109_0165	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Anae109_0165	COG0662	Cupin 2, conserved barrel domain protein
Anae109_0167	COG1940	carbohydrate kinase activity
Anae109_0180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Anae109_0181	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Anae109_0182	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Anae109_0187	COG0577	efflux transmembrane transporter activity
Anae109_0191	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Anae109_0196	COG1490	D-aminoacyl-tRNA deacylase activity
Anae109_0197	COG0537	adenosine 5'-monophosphoramidase activity
Anae109_0202	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Anae109_0203	COG0287	Prephenate dehydrogenase
Anae109_0204	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Anae109_0205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Anae109_0206	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Anae109_0207	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Anae109_0208	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Anae109_0209	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Anae109_0210	COG0463	Glycosyl transferase, family 2
Anae109_0220	COG0546	phosphoglycolate phosphatase activity
Anae109_0221	COG2814	Major facilitator Superfamily
Anae109_0226	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Anae109_0227	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Anae109_0228	COG0799	negative regulation of ribosome biogenesis
Anae109_0230	COG0697	spore germination
Anae109_0240	COG0493	'glutamate synthase
Anae109_0250	COG1595	DNA-templated transcription, initiation
Anae109_0252	COG0534	Mate efflux family protein
Anae109_0254	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Anae109_0257	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Anae109_0258	COG1040	competence protein
Anae109_0264	COG1297	OPT oligopeptide transporter protein
Anae109_0266	COG0745	RESPONSE REGULATOR receiver
Anae109_0267	COG2264	protein methyltransferase activity
Anae109_0268	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Anae109_0271	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Anae109_0273	COG1278	Cold shock
Anae109_0276	COG0204	Acyl-transferase
Anae109_0278	COG2205	protein histidine kinase activity
Anae109_0279	COG0439	Biotin carboxylase
Anae109_0280	COG0511	ligase activity, forming carbon-carbon bonds
Anae109_0280	COG5016	pyruvate
Anae109_0287	COG0564	pseudouridine synthase activity
Anae109_0288	COG0848	biopolymer transport protein
Anae109_0294	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Anae109_0295	COG0052	Belongs to the universal ribosomal protein uS2 family
Anae109_0298	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Anae109_0298	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Anae109_0299	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Anae109_0302	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Anae109_0303	COG0617	tRNA 3'-terminal CCA addition
Anae109_0304	COG0528	UMP kinase activity
Anae109_0305	COG0233	cytoplasmic translational termination
Anae109_0307	COG3360	Dodecin
Anae109_0309	COG2326	polyphosphate kinase activity
Anae109_0311	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Anae109_0311	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Anae109_0318	COG1640	4-alpha-glucanotransferase
Anae109_0319	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Anae109_0322	COG1063	alcohol dehydrogenase
Anae109_0323	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Anae109_0327	COG0010	Belongs to the arginase family
Anae109_0328	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Anae109_0330	COG0438	transferase activity, transferring glycosyl groups
Anae109_0331	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Anae109_0346	COG0700	Nucleoside recognition
Anae109_0347	COG2715	membrane protein required for spore maturation
Anae109_0349	COG0346	lactoylglutathione lyase activity
Anae109_0352	COG0165	Argininosuccinate lyase
Anae109_0353	COG0019	diaminopimelate decarboxylase activity
Anae109_0354	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Anae109_0355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Anae109_0356	COG0179	Fumarylacetoacetate (FAA) hydrolase
Anae109_0357	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Anae109_0361	COG3647	Membrane
Anae109_0362	COG0235	Class ii aldolase
Anae109_0363	COG0517	IMP dehydrogenase activity
Anae109_0363	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Anae109_0364	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Anae109_0367	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Anae109_0368	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Anae109_0370	COG0159	tryptophan synthase activity
Anae109_0371	COG0133	tryptophan synthase activity
Anae109_0372	COG0135	phosphoribosylanthranilate isomerase activity
Anae109_0373	COG0134	indole-3-glycerol-phosphate synthase activity
Anae109_0374	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Anae109_0375	COG0512	Glutamine amidotransferase of anthranilate synthase
Anae109_0377	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Anae109_0380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Anae109_0380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Anae109_0384	COG0482	sulfurtransferase activity
Anae109_0385	COG0574	Belongs to the PEP-utilizing enzyme family
Anae109_0385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Anae109_0386	COG0768	penicillin binding
Anae109_0388	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Anae109_0390	COG2030	dehydratase
Anae109_0394	COG0811	peptide transport
Anae109_0396	COG2967	ApaG domain
Anae109_0397	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Anae109_0399	COG1408	metallophosphoesterase
Anae109_0401	COG2154	pterin-4-alpha-carbinolamine dehydratase
Anae109_0402	COG2363	Small membrane protein
Anae109_0403	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Anae109_0406	COG1201	RNA secondary structure unwinding
Anae109_0412	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Anae109_0412	COG0116	Belongs to the methyltransferase superfamily
Anae109_0416	COG5002	protein histidine kinase activity
Anae109_0419	COG0573	inorganic phosphate transmembrane transporter activity
Anae109_0420	COG0581	inorganic phosphate transmembrane transporter activity
Anae109_0421	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Anae109_0422	COG0704	Plays a role in the regulation of phosphate uptake
Anae109_0433	COG0488	(ABC) transporter
Anae109_0435	COG0584	glycerophosphoryl diester phosphodiesterase
Anae109_0442	COG0745	RESPONSE REGULATOR receiver
Anae109_0444	COG1573	uracil-dna glycosylase
Anae109_0446	COG0784	Response regulator, receiver
Anae109_0446	COG4191	Histidine kinase
Anae109_0447	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Anae109_0457	COG1678	Uncharacterized ACR, COG1678
Anae109_0459	COG1796	DNA polymerase
Anae109_0459	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Anae109_0462	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Anae109_0463	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Anae109_0464	COG0405	Gamma-glutamyltransferase
Anae109_0466	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Anae109_0466	COG0457	Tetratricopeptide repeat
Anae109_0470	COG2201	protein-glutamate methylesterase activity
Anae109_0472	COG0315	cyclic pyranopterin monophosphate synthase activity
Anae109_0473	COG0492	ferredoxin-NADP+ reductase activity
Anae109_0474	COG4106	trans-aconitate 2-methyltransferase activity
Anae109_0475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Anae109_0475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Anae109_0476	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Anae109_0478	COG0442	prolyl-tRNA aminoacylation
Anae109_0481	COG0596	Alpha beta hydrolase
Anae109_0482	COG0450	alkyl hydroperoxide reductase
Anae109_0484	COG0640	Transcriptional regulator
Anae109_0485	COG1819	glycosyl
Anae109_0493	COG2840	Smr protein MutS2
Anae109_0495	COG1136	(ABC) transporter
Anae109_0497	COG0577	efflux transmembrane transporter activity
Anae109_0497	COG1136	(ABC) transporter
Anae109_0501	COG2132	Multicopper oxidase
Anae109_0502	COG0280	phosphate acetyltransferase
Anae109_0502	COG0281	malic enzyme
Anae109_0505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Anae109_0506	COG2204	response regulator
Anae109_0507	COG0154	amidase activity
Anae109_0509	COG3875	lactate racemase activity
Anae109_0512	COG0640	Transcriptional regulator
Anae109_0516	COG0409	Hydrogenase expression formation protein
Anae109_0517	COG0298	carbon dioxide binding
Anae109_0518	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Anae109_0522	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Anae109_0523	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Anae109_0524	COG5557	Pfam Polysulphide reductase, NrfD
Anae109_0525	COG0437	4 iron, 4 sulfur cluster binding
Anae109_0526	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Anae109_0527	COG1322	Protein conserved in bacteria
Anae109_0529	COG2205	protein histidine kinase activity
Anae109_0531	COG1285	pathogenesis
Anae109_0533	COG2119	membrane
Anae109_0539	COG2205	protein histidine kinase activity
Anae109_0539	COG0784	Response regulator, receiver
Anae109_0541	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Anae109_0545	COG0109	protoheme IX farnesyltransferase activity
Anae109_0545	COG1612	heme a metabolic process
Anae109_0546	COG2885	chlorophyll binding
Anae109_0550	COG0667	Aldo Keto reductase
Anae109_0552	COG3181	Tripartite tricarboxylate transporter family receptor
Anae109_0558	COG2814	Major facilitator Superfamily
Anae109_0559	COG2259	Doxx family
Anae109_0561	COG1063	alcohol dehydrogenase
Anae109_0564	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Anae109_0567	COG1538	Outer membrane efflux protein
Anae109_0572	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Anae109_0573	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Anae109_0582	COG0723	plastoquinol--plastocyanin reductase activity
Anae109_0595	COG3265	gluconokinase activity
Anae109_0596	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Anae109_0598	COG0406	alpha-ribazole phosphatase activity
Anae109_0599	COG0363	glucosamine-6-phosphate deaminase activity
Anae109_0600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Anae109_0601	COG3604	Transcriptional regulator
Anae109_0602	COG0640	Transcriptional regulator
Anae109_0607	COG3177	Filamentation induced by cAMP protein fic
Anae109_0610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anae109_0612	COG0402	S-adenosylhomocysteine deaminase activity
Anae109_0613	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Anae109_0614	COG2204	response regulator
Anae109_0615	COG0745	RESPONSE REGULATOR receiver
Anae109_0619	COG0612	Peptidase, M16
Anae109_0620	COG3852	Histidine kinase
Anae109_0625	COG0745	RESPONSE REGULATOR receiver
Anae109_0630	COG0542	response to heat
Anae109_0631	COG1438	arginine binding
Anae109_0632	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Anae109_0633	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Anae109_0636	COG4232	protein-disulfide reductase activity
Anae109_0637	COG1104	cysteine desulfurase activity
Anae109_0639	COG0316	Belongs to the HesB IscA family
Anae109_0640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Anae109_0641	COG0443	Heat shock 70 kDa protein
Anae109_0642	COG0633	Ferredoxin
Anae109_0643	COG2975	iron-sulfur cluster assembly
Anae109_0644	COG2201	protein-glutamate methylesterase activity
Anae109_0646	COG0835	chemotaxis
Anae109_0647	COG0643	Histidine kinase
Anae109_0647	COG2198	Histidine kinase
Anae109_0648	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Anae109_0650	COG0745	RESPONSE REGULATOR receiver
Anae109_0653	COG0745	RESPONSE REGULATOR receiver
Anae109_0658	COG2201	protein-glutamate methylesterase activity
Anae109_0660	COG0784	Response regulator, receiver
Anae109_0661	COG0217	transcriptional regulatory protein
Anae109_0665	COG0295	cytidine deaminase activity
Anae109_0666	COG0196	riboflavin kinase activity
Anae109_0667	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Anae109_0670	COG4191	Histidine kinase
Anae109_0680	COG4968	Prepilin-type N-terminal cleavage methylation domain
Anae109_0681	COG1131	(ABC) transporter
Anae109_0682	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Anae109_0683	COG4191	Histidine kinase
Anae109_0684	COG2204	response regulator
Anae109_0693	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Anae109_0695	COG0439	Biotin carboxylase
Anae109_0697	COG3267	Type II secretory pathway component ExeA
Anae109_0697	COG3409	Peptidoglycan-binding domain 1 protein
Anae109_0700	COG2217	Heavy metal translocating P-type atpase
Anae109_0702	COG0248	Ppx GppA phosphatase
Anae109_0708	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Anae109_0710	COG2884	Cell division ATP-binding protein ftsE
Anae109_0711	COG2177	Part of the ABC transporter FtsEX involved in
Anae109_0712	COG4942	peptidase
Anae109_0713	COG0793	Belongs to the peptidase S41A family
Anae109_0714	COG1215	transferase activity, transferring glycosyl groups
Anae109_0716	COG1215	transferase activity, transferring glycosyl groups
Anae109_0717	COG0546	phosphoglycolate phosphatase activity
Anae109_0718	COG0552	protein localization to endoplasmic reticulum
Anae109_0719	COG1196	nuclear chromosome segregation
Anae109_0727	COG2165	general secretion pathway protein
Anae109_0728	COG1459	type II secretion system
Anae109_0732	COG2204	response regulator
Anae109_0733	COG0254	rRNA binding
Anae109_0734	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Anae109_0735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Anae109_0736	COG1254	Belongs to the acylphosphatase family
Anae109_0738	COG1530	ribonuclease E activity
Anae109_0739	COG1295	ribonuclease BN
Anae109_0740	COG0776	regulation of translation
Anae109_0741	COG4789	Type iii secretion
Anae109_0747	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Anae109_0753	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Anae109_0754	COG0131	Imidazoleglycerol-phosphate dehydratase
Anae109_0755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Anae109_0756	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Anae109_0757	COG0107	imidazoleglycerol-phosphate synthase activity
Anae109_0759	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Anae109_0764	COG0406	alpha-ribazole phosphatase activity
Anae109_0764	COG0328	RNA-DNA hybrid ribonuclease activity
Anae109_0765	COG0730	response to heat
Anae109_0766	COG0446	pyridine nucleotide-disulphide oxidoreductase
Anae109_0768	COG0242	peptide deformylase activity
Anae109_0770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Anae109_0774	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Anae109_0775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Anae109_0776	COG0497	DNA recombination
Anae109_0777	COG0631	protein serine/threonine phosphatase activity
Anae109_0778	COG0739	heme binding
Anae109_0780	COG0653	protein targeting
Anae109_0785	COG0628	permease
Anae109_0787	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Anae109_0788	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Anae109_0789	COG0739	heme binding
Anae109_0790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Anae109_0791	COG1846	Transcriptional regulator
Anae109_0798	COG0348	domain, Protein
Anae109_0799	COG1366	Belongs to the anti-sigma-factor antagonist family
Anae109_0800	COG1366	Belongs to the anti-sigma-factor antagonist family
Anae109_0801	COG2172	sigma factor antagonist activity
Anae109_0803	COG2205	protein histidine kinase activity
Anae109_0803	COG0784	Response regulator, receiver
Anae109_0803	COG5002	protein histidine kinase activity
Anae109_0805	COG2962	Rard protein
Anae109_0806	COG0589	response to stress
Anae109_0811	COG1592	Rubrerythrin
Anae109_0815	COG0693	protein deglycase activity
Anae109_0819	COG0529	Catalyzes the synthesis of activated sulfate
Anae109_0821	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Anae109_0825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anae109_0826	COG1253	flavin adenine dinucleotide binding
Anae109_0828	COG2890	protein-(glutamine-N5) methyltransferase activity
Anae109_0830	COG0508	dehydrogenase complex catalyzes the overall conversion of
Anae109_0833	COG1643	Atp-dependent helicase
Anae109_0836	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Anae109_0837	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Anae109_0839	COG1595	DNA-templated transcription, initiation
Anae109_0841	COG0437	4 iron, 4 sulfur cluster binding
Anae109_0848	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Anae109_0854	COG0070	glutamate synthase
Anae109_0854	COG0069	glutamate synthase activity
Anae109_0854	COG0067	glutamate synthase
Anae109_0855	COG0493	'glutamate synthase
Anae109_0859	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Anae109_0861	COG0437	4 iron, 4 sulfur cluster binding
Anae109_0862	COG0243	molybdopterin cofactor binding
Anae109_0862	COG3383	formate dehydrogenase (NAD+) activity
Anae109_0864	COG3973	AAA domain
Anae109_0865	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Anae109_0873	COG0811	peptide transport
Anae109_0878	COG0488	(ABC) transporter
Anae109_0880	COG0745	RESPONSE REGULATOR receiver
Anae109_0881	COG2205	protein histidine kinase activity
Anae109_0884	COG1309	transcriptional regulator
Anae109_0885	COG0300	oxidoreductase activity
Anae109_0887	COG1012	belongs to the aldehyde dehydrogenase family
Anae109_0890	COG3852	Histidine kinase
Anae109_0892	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Anae109_0893	COG1131	(ABC) transporter
Anae109_0894	COG1131	(ABC) transporter
Anae109_0895	COG0842	Transport permease protein
Anae109_0896	COG0842	Transport permease protein
Anae109_0897	COG1131	(ABC) transporter
Anae109_0898	COG0842	Transport permease protein
Anae109_0900	COG0514	ATP-dependent DNA helicase (RecQ)
Anae109_0901	COG4681	YaeQ
Anae109_0903	COG0719	Fe-S assembly protein
Anae109_0904	COG0396	ATPase activity
Anae109_0905	COG0719	Fe-S assembly protein
Anae109_0906	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Anae109_0907	COG0822	iron-sulfur transferase activity
Anae109_0912	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anae109_0913	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anae109_0915	COG2197	response regulator
Anae109_0920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Anae109_0921	COG0058	SHG alpha-glucan phosphorylase activity
Anae109_0924	COG1704	LemA family
Anae109_0929	COG1396	sequence-specific DNA binding
Anae109_0930	COG0745	RESPONSE REGULATOR receiver
Anae109_0938	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Anae109_0941	COG0668	transmembrane transport
Anae109_0944	COG2322	membrane
Anae109_0946	COG0109	protoheme IX farnesyltransferase activity
Anae109_0949	COG0037	tRNA processing
Anae109_0950	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Anae109_0951	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Anae109_0953	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Anae109_0955	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Anae109_0956	COG3005	denitrification pathway
Anae109_0965	COG2204	response regulator
Anae109_0966	COG4191	Histidine kinase
Anae109_0967	COG2873	o-acetylhomoserine
Anae109_0970	COG0432	Pfam Uncharacterised protein family UPF0047
Anae109_0974	COG1192	Involved in chromosome partitioning
Anae109_0975	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Anae109_0978	COG0584	glycerophosphoryl diester phosphodiesterase
Anae109_0981	COG1271	oxidase subunit
Anae109_0982	COG1294	oxidase, subunit
Anae109_0984	COG1331	Highly conserved protein containing a thioredoxin domain
Anae109_0989	COG3158	transport of potassium into the cell
Anae109_0990	COG2814	Major facilitator Superfamily
Anae109_0991	COG2814	Major facilitator Superfamily
Anae109_0992	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Anae109_0993	COG0632	four-way junction helicase activity
Anae109_0997	COG2255	four-way junction helicase activity
Anae109_1001	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Anae109_1007	COG3285	dna ligase
Anae109_1007	COG1793	dna ligase
Anae109_1010	COG0427	acetyl-CoA hydrolase
Anae109_1017	COG2204	response regulator
Anae109_1023	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Anae109_1024	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Anae109_1027	COG4191	Histidine kinase
Anae109_1028	COG1368	sulfuric ester hydrolase activity
Anae109_1030	COG2133	pyrroloquinoline quinone binding
Anae109_1033	COG2205	protein histidine kinase activity
Anae109_1039	COG1309	transcriptional regulator
Anae109_1040	COG5002	protein histidine kinase activity
Anae109_1040	COG3850	Histidine kinase
Anae109_1041	COG0569	domain protein
Anae109_1043	COG0577	efflux transmembrane transporter activity
Anae109_1043	COG1136	(ABC) transporter
Anae109_1051	COG1252	NADH dehydrogenase
Anae109_1054	COG0633	Ferredoxin
Anae109_1054	COG0543	2 iron, 2 sulfur cluster binding
Anae109_1055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Anae109_1058	COG0596	Alpha beta hydrolase
Anae109_1065	COG0640	Transcriptional regulator
Anae109_1076	COG3328	transposase activity
Anae109_1084	COG1715	Restriction endonuclease
Anae109_1088	COG1335	isochorismatase
Anae109_1090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Anae109_1091	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Anae109_1093	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Anae109_1094	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Anae109_1095	COG1692	metallophosphoesterase
Anae109_1097	COG0515	serine threonine protein kinase
Anae109_1098	COG1104	cysteine desulfurase activity
Anae109_1100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Anae109_1104	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Anae109_1105	COG2204	response regulator
Anae109_1108	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anae109_1109	COG4221	oxidoreductase activity
Anae109_1110	COG5000	phosphorelay sensor kinase activity
Anae109_1115	COG1543	Belongs to the glycosyl hydrolase 57 family
Anae109_1117	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Anae109_1119	COG1136	(ABC) transporter
Anae109_1120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Anae109_1122	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Anae109_1123	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Anae109_1124	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Anae109_1125	COG3494	Protein of unknown function (DUF1009)
Anae109_1126	COG1872	DUF167
Anae109_1128	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Anae109_1129	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Anae109_1130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Anae109_1132	COG1570	exodeoxyribonuclease VII activity
Anae109_1133	COG1722	exodeoxyribonuclease VII activity
Anae109_1134	COG0745	RESPONSE REGULATOR receiver
Anae109_1135	COG0142	geranyltranstransferase activity
Anae109_1136	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Anae109_1137	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Anae109_1138	COG0779	Required for maturation of 30S ribosomal subunits
Anae109_1141	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Anae109_1143	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Anae109_1144	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Anae109_1145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Anae109_1146	COG1185	polyribonucleotide nucleotidyltransferase activity
Anae109_1147	COG0756	dUTP diphosphatase activity
Anae109_1148	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Anae109_1154	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anae109_1158	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Anae109_1159	COG0745	RESPONSE REGULATOR receiver
Anae109_1160	COG0314	molybdopterin synthase activity
Anae109_1161	COG0750	zinc metalloprotease
Anae109_1162	COG2078	PFAM AMMECR1 domain protein
Anae109_1162	COG3885	ferrous iron binding
Anae109_1163	COG2816	NAD+ diphosphatase activity
Anae109_1169	COG1164	Oligoendopeptidase f
Anae109_1174	COG0559	Belongs to the binding-protein-dependent transport system permease family
Anae109_1180	COG1324	tolerance protein
Anae109_1183	COG0515	serine threonine protein kinase
Anae109_1185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Anae109_1186	COG0616	signal peptide processing
Anae109_1187	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Anae109_1191	COG1408	metallophosphoesterase
Anae109_1195	COG0450	alkyl hydroperoxide reductase
Anae109_1196	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Anae109_1201	COG1100	Small GTP-binding protein
Anae109_1203	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Anae109_1211	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anae109_1212	COG0318	PFAM AMP-dependent synthetase and ligase
Anae109_1213	COG3875	lactate racemase activity
Anae109_1217	COG0243	molybdopterin cofactor binding
Anae109_1218	COG3278	Belongs to the heme-copper respiratory oxidase family
Anae109_1222	COG0348	domain, Protein
Anae109_1225	COG2217	Heavy metal translocating P-type atpase
Anae109_1230	COG0438	transferase activity, transferring glycosyl groups
Anae109_1241	COG0297	glycogen (starch) synthase activity
Anae109_1243	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Anae109_1244	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Anae109_1247	COG0367	asparagine synthase
Anae109_1248	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Anae109_1249	COG0318	PFAM AMP-dependent synthetase and ligase
Anae109_1250	COG1086	Polysaccharide biosynthesis protein
Anae109_1252	COG1049	propionate catabolic process, 2-methylcitrate cycle
Anae109_1258	COG0114	fumarate hydratase activity
Anae109_1262	COG0693	protein deglycase activity
Anae109_1263	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Anae109_1264	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Anae109_1268	COG1355	regulation of microtubule-based process
Anae109_1270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Anae109_1272	COG0443	Heat shock 70 kDa protein
Anae109_1273	COG0484	heat shock protein binding
Anae109_1275	COG0010	Belongs to the arginase family
Anae109_1276	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Anae109_1277	COG1959	2 iron, 2 sulfur cluster binding
Anae109_1278	COG0613	PHP domain protein
Anae109_1279	COG1007	ATP synthesis coupled electron transport
Anae109_1281	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Anae109_1282	COG0713	ATP synthesis coupled electron transport
Anae109_1284	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Anae109_1286	COG0649	NAD binding
Anae109_1287	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1288	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1289	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1291	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1292	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1293	COG0649	NAD binding
Anae109_1294	COG1034	ATP synthesis coupled electron transport
Anae109_1295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Anae109_1296	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_1299	COG2814	Major facilitator Superfamily
Anae109_1302	COG1796	DNA polymerase
Anae109_1302	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Anae109_1304	COG0521	Mo-molybdopterin cofactor biosynthetic process
Anae109_1305	COG2201	protein-glutamate methylesterase activity
Anae109_1309	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Anae109_1310	COG0011	TIGRFAM Protein of
Anae109_1317	COG0586	Pfam SNARE associated Golgi protein
Anae109_1318	COG2385	sporulation resulting in formation of a cellular spore
Anae109_1319	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Anae109_1323	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Anae109_1324	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Anae109_1327	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Anae109_1327	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Anae109_1336	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Anae109_1339	COG1597	lipid kinase activity
Anae109_1341	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anae109_1343	COG0612	Peptidase, M16
Anae109_1346	COG2022	thiamine diphosphate biosynthetic process
Anae109_1348	COG0352	thiamine-phosphate diphosphorylase activity
Anae109_1357	COG1074	ATP-dependent DNA helicase activity
Anae109_1366	COG0424	maF-like protein
Anae109_1370	COG0768	penicillin binding
Anae109_1371	COG0772	Belongs to the SEDS family
Anae109_1372	COG3118	belongs to the thioredoxin family
Anae109_1374	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Anae109_1375	COG0181	hydroxymethylbilane synthase activity
Anae109_1378	COG0585	pseudouridine synthase activity
Anae109_1385	COG2197	response regulator
Anae109_1387	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Anae109_1388	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Anae109_1389	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Anae109_1389	COG0446	pyridine nucleotide-disulphide oxidoreductase
Anae109_1398	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anae109_1399	COG0138	bifunctional purine biosynthesis protein purh
Anae109_1408	COG1216	Glycosyl transferase, family 2
Anae109_1409	COG0438	transferase activity, transferring glycosyl groups
Anae109_1410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Anae109_1412	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Anae109_1413	COG0009	L-threonylcarbamoyladenylate synthase
Anae109_1415	COG0113	porphobilinogen synthase activity
Anae109_1418	COG1181	Belongs to the D-alanine--D-alanine ligase family
Anae109_1424	COG0438	transferase activity, transferring glycosyl groups
Anae109_1425	COG0438	transferase activity, transferring glycosyl groups
Anae109_1426	COG0438	transferase activity, transferring glycosyl groups
Anae109_1429	COG1876	peptidase activity
Anae109_1432	COG1181	Belongs to the D-alanine--D-alanine ligase family
Anae109_1433	COG2815	serine threonine protein kinase
Anae109_1433	COG0515	serine threonine protein kinase
Anae109_1436	COG1139	Iron-sulfur cluster binding protein
Anae109_1437	COG0247	lactate metabolic process
Anae109_1438	COG1620	l-lactate permease
Anae109_1440	COG3279	Response regulator of the LytR AlgR family
Anae109_1441	COG3275	phosphorelay sensor kinase activity
Anae109_1443	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Anae109_1445	COG0303	'Molybdopterin
Anae109_1447	COG0557	exoribonuclease II activity
Anae109_1448	COG0730	response to heat
Anae109_1450	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Anae109_1452	COG0411	ABC transporter
Anae109_1454	COG0559	Belongs to the binding-protein-dependent transport system permease family
Anae109_1457	COG1193	negative regulation of DNA recombination
Anae109_1460	COG0438	transferase activity, transferring glycosyl groups
Anae109_1462	COG3876	Protein conserved in bacteria
Anae109_1466	COG0542	response to heat
Anae109_1467	COG1752	Esterase of the alpha-beta hydrolase superfamily
Anae109_1472	COG0459	protein refolding
Anae109_1474	COG3706	GGDEF domain
Anae109_1477	COG0525	valine-tRNA ligase activity
Anae109_1479	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Anae109_1479	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Anae109_1480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Anae109_1483	COG0728	peptidoglycan biosynthetic process
Anae109_1489	COG1595	DNA-templated transcription, initiation
Anae109_1491	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Anae109_1492	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Anae109_1492	COG2205	protein histidine kinase activity
Anae109_1495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Anae109_1498	COG5002	protein histidine kinase activity
Anae109_1500	COG1573	uracil-dna glycosylase
Anae109_1502	COG0330	HflC and HflK could
Anae109_1505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Anae109_1509	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Anae109_1511	COG0501	Belongs to the peptidase M48B family
Anae109_1518	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anae109_1520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Anae109_1521	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anae109_1522	COG0586	Pfam SNARE associated Golgi protein
Anae109_1523	COG0443	Heat shock 70 kDa protein
Anae109_1524	COG0517	IMP dehydrogenase activity
Anae109_1524	COG0516	GMP reductase activity
Anae109_1525	COG0519	Catalyzes the synthesis of GMP from XMP
Anae109_1525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Anae109_1532	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Anae109_1534	COG3746	phosphate-selective porin O and P
Anae109_1536	COG1121	(ABC) transporter
Anae109_1543	COG3093	addiction module antidote protein HigA
Anae109_1544	COG3012	SEC-C Motif Domain Protein
Anae109_1545	COG2155	Conserved Protein
Anae109_1558	COG3220	belongs to the UPF0276 family
Anae109_1564	COG0667	Aldo Keto reductase
Anae109_1568	COG0443	Heat shock 70 kDa protein
Anae109_1570	COG3047	cAMP biosynthetic process
Anae109_1570	COG2885	chlorophyll binding
Anae109_1572	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Anae109_1585	COG1793	dna ligase
Anae109_1589	COG0039	L-malate dehydrogenase activity
Anae109_1591	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Anae109_1596	COG1966	Carbon starvation protein
Anae109_1597	COG0784	Response regulator, receiver
Anae109_1597	COG2205	protein histidine kinase activity
Anae109_1603	COG2204	response regulator
Anae109_1609	COG2264	protein methyltransferase activity
Anae109_1612	COG0217	transcriptional regulatory protein
Anae109_1614	COG4109	DRTGG domain
Anae109_1615	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Anae109_1617	COG1131	(ABC) transporter
Anae109_1625	COG1252	NADH dehydrogenase
Anae109_1631	COG0488	(ABC) transporter
Anae109_1636	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_1638	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Anae109_1639	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Anae109_1640	COG4208	sulfate ABC transporter
Anae109_1642	COG0529	Catalyzes the synthesis of activated sulfate
Anae109_1643	COG2895	sulfate adenylyltransferase (ATP) activity
Anae109_1649	COG0318	PFAM AMP-dependent synthetase and ligase
Anae109_1652	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Anae109_1655	COG1271	oxidase subunit
Anae109_1656	COG1294	oxidase, subunit
Anae109_1662	COG3842	ATPase activity
Anae109_1664	COG3833	ABC-type maltose transport systems, permease component
Anae109_1665	COG1012	belongs to the aldehyde dehydrogenase family
Anae109_1666	COG0431	NADPH-dependent FMN reductase
Anae109_1667	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Anae109_1671	COG2205	protein histidine kinase activity
Anae109_1672	COG0671	phosphoesterase, PA-phosphatase related
Anae109_1674	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_1676	COG0559	Belongs to the binding-protein-dependent transport system permease family
Anae109_1678	COG0410	ABC transporter
Anae109_1681	COG0667	Aldo Keto reductase
Anae109_1684	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Anae109_1694	COG3842	ATPase activity
Anae109_1697	COG1653	transport
Anae109_1699	COG0259	pyridoxamine-phosphate oxidase activity
Anae109_1701	COG2832	Protein of unknown function (DUF454)
Anae109_1703	COG0408	coproporphyrinogen oxidase activity
Anae109_1704	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Anae109_1707	COG1704	LemA family
Anae109_1708	COG0501	Belongs to the peptidase M48B family
Anae109_1710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Anae109_1713	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Anae109_1719	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Anae109_1720	COG2270	Major facilitator Superfamily
Anae109_1722	COG2205	protein histidine kinase activity
Anae109_1722	COG0784	Response regulator, receiver
Anae109_1724	COG1201	RNA secondary structure unwinding
Anae109_1725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Anae109_1727	COG0723	plastoquinol--plastocyanin reductase activity
Anae109_1727	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Anae109_1731	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Anae109_1741	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Anae109_1743	COG0328	RNA-DNA hybrid ribonuclease activity
Anae109_1744	COG2195	Cleaves the N-terminal amino acid of tripeptides
Anae109_1753	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Anae109_1754	COG0473	3-isopropylmalate dehydrogenase activity
Anae109_1755	COG4783	chaperone-mediated protein folding
Anae109_1757	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Anae109_1759	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Anae109_1760	COG3033	Beta-eliminating lyase
Anae109_1765	COG0351	phosphomethylpyrimidine kinase
Anae109_1767	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Anae109_1772	COG1136	(ABC) transporter
Anae109_1773	COG1136	(ABC) transporter
Anae109_1773	COG0577	efflux transmembrane transporter activity
Anae109_1775	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Anae109_1782	COG0569	domain protein
Anae109_1790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Anae109_1792	COG0583	DNA-binding transcription factor activity
Anae109_1795	COG0788	formyltetrahydrofolate deformylase activity
Anae109_1798	COG2204	response regulator
Anae109_1800	COG0437	4 iron, 4 sulfur cluster binding
Anae109_1800	COG3064	Membrane
Anae109_1801	COG5557	Pfam Polysulphide reductase, NrfD
Anae109_1807	COG0501	Belongs to the peptidase M48B family
Anae109_1810	COG2197	response regulator
Anae109_1815	COG2226	methyltransferase
Anae109_1818	COG1215	transferase activity, transferring glycosyl groups
Anae109_1821	COG1216	Glycosyl transferase, family 2
Anae109_1822	COG1216	Glycosyl transferase, family 2
Anae109_1825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Anae109_1845	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Anae109_1846	COG4191	Histidine kinase
Anae109_1847	COG2204	response regulator
Anae109_1848	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anae109_1850	COG0745	RESPONSE REGULATOR receiver
Anae109_1851	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Anae109_1854	COG5002	protein histidine kinase activity
Anae109_1864	COG0598	Magnesium transport protein CorA
Anae109_1866	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Anae109_1874	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Anae109_1875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Anae109_1876	COG0066	3-isopropylmalate dehydratase activity
Anae109_1880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Anae109_1881	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Anae109_1882	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Anae109_1883	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Anae109_1884	COG0072	phenylalanine-tRNA ligase activity
Anae109_1886	COG0776	regulation of translation
Anae109_1887	COG0720	synthase
Anae109_1888	COG0302	gtp cyclohydrolase
Anae109_1889	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_1890	COG0277	FAD linked oxidase domain protein
Anae109_1891	COG0674	pyruvate-flavodoxin oxidoreductase activity
Anae109_1891	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Anae109_1892	COG1013	pyruvate-flavodoxin oxidoreductase activity
Anae109_1894	COG0674	pyruvate-flavodoxin oxidoreductase activity
Anae109_1894	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Anae109_1895	COG1013	pyruvate-flavodoxin oxidoreductase activity
Anae109_1903	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Anae109_1907	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Anae109_1908	COG0049	tRNA binding
Anae109_1909	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Anae109_1910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Anae109_1912	COG0088	Forms part of the polypeptide exit tunnel
Anae109_1913	COG0089	rRNA binding
Anae109_1914	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Anae109_1915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Anae109_1916	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Anae109_1917	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Anae109_1918	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Anae109_1919	COG0255	Belongs to the universal ribosomal protein uL29 family
Anae109_1920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Anae109_1921	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Anae109_1922	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Anae109_1923	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Anae109_1924	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Anae109_1925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Anae109_1926	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Anae109_1927	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Anae109_1928	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Anae109_1929	COG1841	ribosomal large subunit assembly
Anae109_1930	COG0200	Binds to the 23S rRNA
Anae109_1931	COG0201	protein transport
Anae109_1932	COG0563	adenylate kinase activity
Anae109_1935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Anae109_1936	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Anae109_1937	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Anae109_1938	COG0202	RNA polymerase activity
Anae109_1939	COG0203	ribosomal protein L17
Anae109_1941	COG0228	four-way junction DNA binding
Anae109_1942	COG1837	Belongs to the UPF0109 family
Anae109_1943	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Anae109_1944	COG0336	Belongs to the RNA methyltransferase TrmD family
Anae109_1945	COG0335	large ribosomal subunit rRNA binding
Anae109_1947	COG0792	nuclease activity
Anae109_1948	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Anae109_1952	COG3852	Histidine kinase
Anae109_1955	COG0455	bacterial-type flagellum organization
Anae109_1958	COG0564	pseudouridine synthase activity
Anae109_1964	COG1166	arginine decarboxylase activity
Anae109_1966	COG3360	Dodecin
Anae109_1967	COG2226	methyltransferase
Anae109_1976	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Anae109_1981	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Anae109_1982	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Anae109_1990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Anae109_1992	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Anae109_1994	COG0022	dehydrogenase e1 component
Anae109_1997	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Anae109_2001	COG0527	aspartate kinase activity
Anae109_2005	COG0784	Response regulator, receiver
Anae109_2005	COG2205	protein histidine kinase activity
Anae109_2006	COG0436	Aminotransferase
Anae109_2007	COG3383	formate dehydrogenase (NAD+) activity
Anae109_2007	COG0243	molybdopterin cofactor binding
Anae109_2008	COG3383	formate dehydrogenase (NAD+) activity
Anae109_2008	COG0243	molybdopterin cofactor binding
Anae109_2009	COG0437	4 iron, 4 sulfur cluster binding
Anae109_2010	COG2864	formate dehydrogenase
Anae109_2011	COG3058	Necessary for formate dehydrogenase activity
Anae109_2022	COG0443	Heat shock 70 kDa protein
Anae109_2026	COG0698	ribose 5-phosphate isomerase
Anae109_2029	COG0745	RESPONSE REGULATOR receiver
Anae109_2030	COG5002	protein histidine kinase activity
Anae109_2033	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_2037	COG0546	phosphoglycolate phosphatase activity
Anae109_2038	COG1970	mechanosensitive ion channel activity
Anae109_2040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Anae109_2040	COG0646	methionine synthase
Anae109_2041	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Anae109_2045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Anae109_2046	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anae109_2052	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Anae109_2053	COG0560	Phosphoserine phosphatase
Anae109_2061	COG2267	carboxylic ester hydrolase activity
Anae109_2064	COG0742	ribosomal rna small subunit methyltransferase
Anae109_2065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Anae109_2072	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Anae109_2074	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Anae109_2075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Anae109_2077	COG0436	Aminotransferase
Anae109_2080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Anae109_2081	COG1058	Belongs to the CinA family
Anae109_2081	COG1546	Belongs to the CinA family
Anae109_2086	COG0166	Belongs to the GPI family
Anae109_2088	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Anae109_2092	COG2204	response regulator
Anae109_2094	COG2815	serine threonine protein kinase
Anae109_2094	COG0515	serine threonine protein kinase
Anae109_2096	COG0667	Aldo Keto reductase
Anae109_2098	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Anae109_2104	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Anae109_2107	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Anae109_2110	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Anae109_2111	COG0860	N-Acetylmuramoyl-L-alanine amidase
Anae109_2112	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Anae109_2113	COG0189	ligase activity
Anae109_2116	COG0009	L-threonylcarbamoyladenylate synthase
Anae109_2117	COG4974	Belongs to the 'phage' integrase family
Anae109_2118	COG1994	Peptidase M50
Anae109_2119	COG0180	Tryptophanyl-tRNA synthetase
Anae109_2120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Anae109_2121	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Anae109_2122	COG1187	pseudouridine synthase activity
Anae109_2128	COG0430	RNA-3'-phosphate cyclase activity
Anae109_2129	COG0598	Magnesium transport protein CorA
Anae109_2130	COG0489	protein tyrosine kinase activity
Anae109_2134	COG1250	3-hydroxyacyl-CoA dehydrogenase
Anae109_2135	COG1024	Enoyl-CoA hydratase
Anae109_2136	COG1960	acyl-CoA dehydrogenase activity
Anae109_2137	COG1960	acyl-CoA dehydrogenase activity
Anae109_2138	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Anae109_2142	COG5002	protein histidine kinase activity
Anae109_2144	COG0419	ATPase involved in DNA repair
Anae109_2145	COG0420	3'-5' exonuclease activity
Anae109_2147	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Anae109_2148	COG0450	alkyl hydroperoxide reductase
Anae109_2155	COG1160	GTP binding
Anae109_2156	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Anae109_2159	COG0571	ribonuclease III activity
Anae109_2162	COG0110	maltose O-acetyltransferase activity
Anae109_2163	COG1960	acyl-CoA dehydrogenase activity
Anae109_2164	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Anae109_2165	COG1024	Enoyl-CoA hydratase
Anae109_2166	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Anae109_2167	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Anae109_2168	COG0148	phosphopyruvate hydratase activity
Anae109_2171	COG1494	fructose-1,6-bisphosphatase
Anae109_2180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Anae109_2181	COG1253	flavin adenine dinucleotide binding
Anae109_2182	COG0105	UTP biosynthetic process
Anae109_2183	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Anae109_2185	COG0039	L-malate dehydrogenase activity
Anae109_2186	COG0538	isocitrate dehydrogenase activity
Anae109_2187	COG3394	polysaccharide catabolic process
Anae109_2188	COG4191	Histidine kinase
Anae109_2191	COG0505	Belongs to the CarA family
Anae109_2193	COG0540	Belongs to the ATCase OTCase family
Anae109_2194	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Anae109_2196	COG0681	Belongs to the peptidase S26 family
Anae109_2197	COG0481	GTPase activity
Anae109_2198	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Anae109_2204	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Anae109_2205	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Anae109_2206	COG5002	protein histidine kinase activity
Anae109_2210	COG0741	lytic transglycosylase activity
Anae109_2211	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Anae109_2215	COG0745	RESPONSE REGULATOR receiver
Anae109_2217	COG1317	bacterial-type flagellum organization
Anae109_2218	COG0864	Transcriptional regulator
Anae109_2220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Anae109_2221	COG0085	RNA polymerase activity
Anae109_2222	COG0222	ribosome binding
Anae109_2223	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Anae109_2224	COG0081	regulation of translation
Anae109_2225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Anae109_2228	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Anae109_2229	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Anae109_2230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Anae109_2232	COG0189	ligase activity
Anae109_2233	COG0443	Heat shock 70 kDa protein
Anae109_2235	COG2205	protein histidine kinase activity
Anae109_2235	COG0784	Response regulator, receiver
Anae109_2235	COG5002	protein histidine kinase activity
Anae109_2238	COG2921	Belongs to the UPF0250 family
Anae109_2239	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Anae109_2240	COG0745	RESPONSE REGULATOR receiver
Anae109_2240	COG3706	GGDEF domain
Anae109_2247	COG1730	sister chromatid segregation
Anae109_2257	COG3706	GGDEF domain
Anae109_2257	COG0745	RESPONSE REGULATOR receiver
Anae109_2258	COG2204	response regulator
Anae109_2259	COG4191	Histidine kinase
Anae109_2263	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Anae109_2264	COG0443	Heat shock 70 kDa protein
Anae109_2266	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Anae109_2269	COG0101	tRNA pseudouridine synthase activity
Anae109_2271	COG1606	tRNA processing
Anae109_2272	COG2046	Belongs to the sulfate adenylyltransferase family
Anae109_2272	COG0529	Catalyzes the synthesis of activated sulfate
Anae109_2275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Anae109_2280	COG0149	triose-phosphate isomerase activity
Anae109_2281	COG0126	phosphoglycerate kinase activity
Anae109_2282	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Anae109_2284	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Anae109_2288	COG0018	arginyl-trna synthetase
Anae109_2291	COG0616	signal peptide processing
Anae109_2292	COG3273	potassium ion transport
Anae109_2292	COG0471	metal ion transport
Anae109_2293	COG0835	chemotaxis
Anae109_2298	COG2201	protein-glutamate methylesterase activity
Anae109_2301	COG0539	negative regulation of cytoplasmic translation
Anae109_2302	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Anae109_2303	COG1122	ATPase activity
Anae109_2305	COG0310	cobalt ion transport
Anae109_2309	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Anae109_2310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Anae109_2311	COG0825	malonyl-CoA metabolic process
Anae109_2312	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Anae109_2315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Anae109_2322	COG3209	COG3209 Rhs family protein
Anae109_2324	COG3209	COG3209 Rhs family protein
Anae109_2325	COG3209	COG3209 Rhs family protein
Anae109_2326	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Anae109_2329	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Anae109_2330	COG0802	atpase or kinase
Anae109_2331	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Anae109_2331	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Anae109_2332	COG0736	holo-[acyl-carrier-protein] synthase activity
Anae109_2333	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Anae109_2334	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Anae109_2336	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Anae109_2337	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Anae109_2338	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anae109_2339	COG0037	tRNA processing
Anae109_2345	COG3246	L-lysine catabolic process to acetate
Anae109_2346	COG1607	acyl-coa hydrolase
Anae109_2347	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Anae109_2349	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Anae109_2350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anae109_2351	COG0482	sulfurtransferase activity
Anae109_2352	COG2205	protein histidine kinase activity
Anae109_2353	COG0617	tRNA 3'-terminal CCA addition
Anae109_2356	COG2205	protein histidine kinase activity
Anae109_2358	COG2226	methyltransferase
Anae109_2360	COG3118	belongs to the thioredoxin family
Anae109_2365	COG5002	protein histidine kinase activity
Anae109_2366	COG2201	protein-glutamate methylesterase activity
Anae109_2370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Anae109_2373	COG3387	PFAM Glycoside hydrolase 15-related
Anae109_2378	COG2205	protein histidine kinase activity
Anae109_2379	COG2204	response regulator
Anae109_2387	COG5002	protein histidine kinase activity
Anae109_2390	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Anae109_2391	COG0745	RESPONSE REGULATOR receiver
Anae109_2402	COG0343	queuine tRNA-ribosyltransferase activity
Anae109_2403	COG0429	hydrolase of the alpha beta-hydrolase fold
Anae109_2407	COG0437	4 iron, 4 sulfur cluster binding
Anae109_2409	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anae109_2413	COG0038	chloride channel
Anae109_2417	COG0308	aminopeptidase N
Anae109_2422	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Anae109_2423	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Anae109_2424	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Anae109_2429	COG3604	Transcriptional regulator
Anae109_2432	COG1763	Mo-molybdopterin cofactor biosynthetic process
Anae109_2433	COG0303	'Molybdopterin
Anae109_2435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Anae109_2437	COG0517	IMP dehydrogenase activity
Anae109_2438	COG2205	protein histidine kinase activity
Anae109_2439	COG0745	RESPONSE REGULATOR receiver
Anae109_2439	COG4566	intracellular signal transduction
Anae109_2440	COG3852	Histidine kinase
Anae109_2443	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Anae109_2445	COG1335	isochorismatase
Anae109_2448	COG0084	hydrolase, TatD family'
Anae109_2449	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Anae109_2449	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Anae109_2452	COG5002	protein histidine kinase activity
Anae109_2452	COG2198	Histidine kinase
Anae109_2452	COG0784	Response regulator, receiver
Anae109_2454	COG0288	reversible hydration of carbon dioxide
Anae109_2460	COG0752	glycyl-tRNA synthetase alpha subunit
Anae109_2462	COG1381	Involved in DNA repair and RecF pathway recombination
Anae109_2463	COG1426	Protein conserved in bacteria
Anae109_2467	COG0602	queuosine metabolic process
Anae109_2468	COG0741	lytic transglycosylase activity
Anae109_2471	COG0167	dihydroorotate dehydrogenase activity
Anae109_2476	COG2937	Belongs to the GPAT DAPAT family
Anae109_2478	COG0483	inositol monophosphate 1-phosphatase activity
Anae109_2480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anae109_2486	COG1045	serine acetyltransferase
Anae109_2488	COG0322	excinuclease ABC activity
Anae109_2490	COG3258	Cytochrome c
Anae109_2491	COG4191	Histidine kinase
Anae109_2493	COG0556	nucleotide-excision repair
Anae109_2494	COG1278	Cold shock
Anae109_2496	COG0215	cysteine-tRNA ligase activity
Anae109_2497	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Anae109_2497	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Anae109_2498	COG1329	Transcriptional regulator
Anae109_2504	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Anae109_2505	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Anae109_2506	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Anae109_2507	COG1309	transcriptional regulator
Anae109_2508	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Anae109_2511	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Anae109_2512	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Anae109_2513	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Anae109_2515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Anae109_2520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Anae109_2522	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Anae109_2524	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Anae109_2525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Anae109_2529	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Anae109_2531	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Anae109_2532	COG1278	Cold shock
Anae109_2535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Anae109_2536	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Anae109_2537	COG2766	serine protein kinase
Anae109_2538	COG2718	Belongs to the UPF0229 family
Anae109_2539	COG2719	SpoVR family
Anae109_2540	COG1196	nuclear chromosome segregation
Anae109_2540	COG0739	heme binding
Anae109_2540	COG0741	lytic transglycosylase activity
Anae109_2549	COG1047	Peptidyl-prolyl cis-trans
Anae109_2553	COG3411	Ferredoxin
Anae109_2554	COG2912	Transglutaminase-like superfamily
Anae109_2556	COG2207	Transcriptional regulator
Anae109_2557	COG3848	Pyruvate phosphate dikinase
Anae109_2557	COG0574	Belongs to the PEP-utilizing enzyme family
Anae109_2558	COG0574	Belongs to the PEP-utilizing enzyme family
Anae109_2558	COG3848	Pyruvate phosphate dikinase
Anae109_2559	COG1741	Belongs to the pirin family
Anae109_2560	COG5001	Diguanylate cyclase
Anae109_2560	COG5002	protein histidine kinase activity
Anae109_2560	COG3447	MASE1 domain protein
Anae109_2562	COG1394	ATPase activity, coupled to movement of substances
Anae109_2563	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Anae109_2564	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Anae109_2569	COG1269	ATP hydrolysis coupled proton transport
Anae109_2573	COG0194	GDP metabolic process
Anae109_2574	COG1561	YicC-like family, N-terminal region
Anae109_2575	COG2835	tetraacyldisaccharide 4'-kinase activity
Anae109_2577	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Anae109_2577	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Anae109_2580	COG1663	tetraacyldisaccharide 4'-kinase activity
Anae109_2581	COG0859	PFAM glycosyl transferase family 9
Anae109_2582	COG1519	Transferase
Anae109_2584	COG1132	(ABC) transporter
Anae109_2585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Anae109_2586	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Anae109_2587	COG2095	MarC family integral membrane protein
Anae109_2588	COG0463	Glycosyl transferase, family 2
Anae109_2589	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Anae109_2603	COG1053	succinate dehydrogenase
Anae109_2607	COG0438	transferase activity, transferring glycosyl groups
Anae109_2613	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Anae109_2614	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Anae109_2615	COG0489	protein tyrosine kinase activity
Anae109_2620	COG2204	response regulator
Anae109_2622	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Anae109_2628	COG0438	transferase activity, transferring glycosyl groups
Anae109_2630	COG0438	transferase activity, transferring glycosyl groups
Anae109_2632	COG0489	protein tyrosine kinase activity
Anae109_2632	COG3206	protein involved in exopolysaccharide biosynthesis
Anae109_2633	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Anae109_2635	COG1086	Polysaccharide biosynthesis protein
Anae109_2636	COG2385	sporulation resulting in formation of a cellular spore
Anae109_2639	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Anae109_2646	COG0492	ferredoxin-NADP+ reductase activity
Anae109_2649	COG0582	viral genome integration into host DNA
Anae109_2661	COG4269	membrane
Anae109_2667	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Anae109_2668	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Anae109_2672	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Anae109_2675	COG0237	dephospho-CoA kinase activity
Anae109_2680	COG0137	argininosuccinate synthase activity
Anae109_2683	COG0443	Heat shock 70 kDa protein
Anae109_2684	COG0484	heat shock protein binding
Anae109_2686	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Anae109_2687	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Anae109_2688	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Anae109_2691	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Anae109_2693	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Anae109_2694	COG0758	DNA mediated transformation
Anae109_2695	COG1652	LysM domain
Anae109_2698	COG2203	Gaf domain
Anae109_2698	COG3706	GGDEF domain
Anae109_2698	COG4251	negative regulation of phosphorylation
Anae109_2698	COG5001	Diguanylate cyclase
Anae109_2699	COG0745	RESPONSE REGULATOR receiver
Anae109_2699	COG1196	nuclear chromosome segregation
Anae109_2701	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Anae109_2702	COG0542	response to heat
Anae109_2708	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Anae109_2709	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Anae109_2711	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Anae109_2712	COG1480	7TM receptor with intracellular HD hydrolase
Anae109_2714	COG0457	Tetratricopeptide repeat
Anae109_2716	COG3956	TIGRFAM MazG family protein
Anae109_2717	COG0268	Binds directly to 16S ribosomal RNA
Anae109_2719	COG0495	leucyl-tRNA aminoacylation
Anae109_2720	COG0017	Asparaginyl-tRNA synthetase
Anae109_2725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Anae109_2725	COG0392	lysyltransferase activity
Anae109_2727	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Anae109_2728	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Anae109_2729	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Anae109_2729	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Anae109_2731	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Anae109_2731	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Anae109_2732	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Anae109_2733	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Anae109_2734	COG0698	ribose 5-phosphate isomerase
Anae109_2735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Anae109_2736	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anae109_2737	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_2738	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Anae109_2739	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Anae109_2740	COG0416	fatty acid biosynthetic process
Anae109_2741	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Anae109_2747	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Anae109_2750	COG0705	Rhomboid family
Anae109_2750	COG0457	Tetratricopeptide repeat
Anae109_2753	COG3186	Phenylalanine-4-hydroxylase
Anae109_2755	COG0488	(ABC) transporter
Anae109_2758	COG3256	nitric oxide reductase
Anae109_2759	COG2010	Cytochrome c
Anae109_2760	COG1858	cytochrome C peroxidase
Anae109_2764	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_2766	COG1858	cytochrome C peroxidase
Anae109_2774	COG0604	alcohol dehydrogenase
Anae109_2777	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Anae109_2778	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Anae109_2780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Anae109_2783	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Anae109_2790	COG1301	dicarboxylic acid transport
Anae109_2793	COG1067	ATP-dependent peptidase activity
Anae109_2797	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Anae109_2809	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Anae109_2812	COG0406	alpha-ribazole phosphatase activity
Anae109_2813	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Anae109_2815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Anae109_2815	COG1017	nitric oxide dioxygenase activity
Anae109_2818	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Anae109_2818	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Anae109_2819	COG0604	alcohol dehydrogenase
Anae109_2823	COG2205	protein histidine kinase activity
Anae109_2827	COG2323	membrane
Anae109_2831	COG3795	YCII-related domain
Anae109_2832	COG4941	Belongs to the sigma-70 factor family
Anae109_2839	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Anae109_2841	COG0288	reversible hydration of carbon dioxide
Anae109_2842	COG1360	Flagellar Motor Protein
Anae109_2846	COG2234	aminopeptidase activity
Anae109_2847	COG0823	Involved in the tonB-independent uptake of proteins
Anae109_2848	COG0583	DNA-binding transcription factor activity
Anae109_2860	COG1845	cytochrome c oxidase, subunit III
Anae109_2861	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Anae109_2864	COG1845	cytochrome c oxidase, subunit III
Anae109_2866	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Anae109_2874	COG0840	transmembrane signaling receptor activity
Anae109_2875	COG1960	acyl-CoA dehydrogenase activity
Anae109_2876	COG0183	Belongs to the thiolase family
Anae109_2877	COG1250	3-hydroxyacyl-CoA dehydrogenase
Anae109_2877	COG1024	Enoyl-CoA hydratase
Anae109_2885	COG1881	PFAM PEBP family protein
Anae109_2886	COG0667	Aldo Keto reductase
Anae109_2888	COG0346	lactoylglutathione lyase activity
Anae109_2891	COG2827	Endonuclease containing a URI domain
Anae109_2892	COG1752	Esterase of the alpha-beta hydrolase superfamily
Anae109_2907	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Anae109_2909	COG0531	amino acid
Anae109_2915	COG2010	Cytochrome c
Anae109_2915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Anae109_2919	COG0247	lactate metabolic process
Anae109_2920	COG0277	FAD linked oxidase domain protein
Anae109_2921	COG0277	FAD linked oxidase domain protein
Anae109_2924	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Anae109_2928	COG2388	GCN5-related N-acetyl-transferase
Anae109_2929	COG2205	protein histidine kinase activity
Anae109_2931	COG1063	alcohol dehydrogenase
Anae109_2939	COG1032	radical SAM domain protein
Anae109_2941	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Anae109_2946	COG2264	protein methyltransferase activity
Anae109_2947	COG1297	OPT oligopeptide transporter protein
Anae109_2950	COG0517	IMP dehydrogenase activity
Anae109_2951	COG2860	membrane
Anae109_2957	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Anae109_2961	COG0577	efflux transmembrane transporter activity
Anae109_2961	COG1136	(ABC) transporter
Anae109_2963	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Anae109_2968	COG0366	Alpha amylase catalytic
Anae109_2971	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Anae109_2972	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Anae109_2973	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Anae109_2974	COG1064	alcohol dehydrogenase
Anae109_2976	COG4191	Histidine kinase
Anae109_2981	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Anae109_2984	COG0318	PFAM AMP-dependent synthetase and ligase
Anae109_2993	COG1013	pyruvate-flavodoxin oxidoreductase activity
Anae109_2994	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Anae109_2994	COG0674	pyruvate-flavodoxin oxidoreductase activity
Anae109_2995	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Anae109_2999	COG0277	FAD linked oxidase domain protein
Anae109_3000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Anae109_3002	COG1960	acyl-CoA dehydrogenase activity
Anae109_3005	COG2205	protein histidine kinase activity
Anae109_3006	COG0702	epimerase
Anae109_3009	COG1295	ribonuclease BN
Anae109_3011	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Anae109_3013	COG0443	Heat shock 70 kDa protein
Anae109_3018	COG0656	L-ascorbic acid biosynthetic process
Anae109_3019	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Anae109_3019	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Anae109_3020	COG3639	organic phosphonate transmembrane transporter activity
Anae109_3021	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Anae109_3024	COG0535	radical SAM domain protein
Anae109_3027	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anae109_3028	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Anae109_3035	COG3227	Zinc metalloprotease (Elastase)
Anae109_3037	COG0733	neurotransmitter:sodium symporter activity
Anae109_3038	COG1115	amino acid carrier protein
Anae109_3042	COG0437	4 iron, 4 sulfur cluster binding
Anae109_3042	COG3064	Membrane
Anae109_3043	COG3383	formate dehydrogenase (NAD+) activity
Anae109_3043	COG0243	molybdopterin cofactor binding
Anae109_3045	COG3284	Transcriptional regulator
Anae109_3047	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Anae109_3050	COG0667	Aldo Keto reductase
Anae109_3051	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Anae109_3051	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Anae109_3056	COG1174	glycine betaine transport
Anae109_3057	COG1125	glycine betaine transport
Anae109_3057	COG0517	IMP dehydrogenase activity
Anae109_3061	COG5522	Integral membrane protein (intg_mem_TP0381)
Anae109_3062	COG1272	protein, Hemolysin III
Anae109_3065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Anae109_3070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Anae109_3071	COG0366	Alpha amylase catalytic
Anae109_3080	COG0071	Belongs to the small heat shock protein (HSP20) family
Anae109_3094	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Anae109_3095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Anae109_3098	COG1942	4-Oxalocrotonate Tautomerase
Anae109_3099	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Anae109_3101	COG0531	amino acid
Anae109_3103	COG2205	protein histidine kinase activity
Anae109_3104	COG0745	RESPONSE REGULATOR receiver
Anae109_3108	COG2132	Multicopper oxidase
Anae109_3108	COG2132	Multicopper oxidase
Anae109_3108	COG2132	Multicopper oxidase
Anae109_3113	COG1942	4-Oxalocrotonate Tautomerase
Anae109_3125	COG0515	serine threonine protein kinase
Anae109_3125	COG2815	serine threonine protein kinase
Anae109_3126	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Anae109_3126	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Anae109_3139	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Anae109_3146	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Anae109_3151	COG2264	protein methyltransferase activity
Anae109_3154	COG1773	rubredoxin
Anae109_3154	COG1592	Rubrerythrin
Anae109_3155	COG3590	peptidase
Anae109_3158	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Anae109_3161	COG4251	negative regulation of phosphorylation
Anae109_3164	COG0045	succinate-CoA ligase (ADP-forming) activity
Anae109_3164	COG1042	CoA-binding domain protein
Anae109_3164	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Anae109_3166	COG2086	electron transfer activity
Anae109_3168	COG1960	acyl-CoA dehydrogenase activity
Anae109_3169	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Anae109_3169	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Anae109_3169	COG1703	isobutyryl-CoA mutase activity
Anae109_3170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Anae109_3171	COG2226	methyltransferase
Anae109_3172	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Anae109_3173	COG1129	ABC transporter
Anae109_3179	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Anae109_3179	COG1752	Esterase of the alpha-beta hydrolase superfamily
Anae109_3181	COG0628	permease
Anae109_3182	COG1032	radical SAM domain protein
Anae109_3186	COG3040	lipid binding
Anae109_3187	COG3239	Fatty acid desaturase
Anae109_3188	COG2205	protein histidine kinase activity
Anae109_3192	COG2353	YceI-like domain
Anae109_3194	COG3384	dioxygenase
Anae109_3197	COG2855	membrane
Anae109_3199	COG0025	NhaP-type Na H and K H
Anae109_3206	COG0667	Aldo Keto reductase
Anae109_3207	COG1064	alcohol dehydrogenase
Anae109_3208	COG1064	alcohol dehydrogenase
Anae109_3217	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anae109_3218	COG1063	alcohol dehydrogenase
Anae109_3219	COG0673	inositol 2-dehydrogenase activity
Anae109_3222	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Anae109_3226	COG1132	(ABC) transporter
Anae109_3228	COG2205	protein histidine kinase activity
Anae109_3229	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Anae109_3231	COG0583	DNA-binding transcription factor activity
Anae109_3234	COG0641	radical SAM
Anae109_3236	COG0659	secondary active sulfate transmembrane transporter activity
Anae109_3244	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Anae109_3246	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Anae109_3247	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Anae109_3252	COG1764	response to oxidative stress
Anae109_3254	COG1309	transcriptional regulator
Anae109_3255	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_3258	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Anae109_3259	COG2226	methyltransferase
Anae109_3272	COG0653	protein targeting
Anae109_3275	COG2249	NAD(P)H dehydrogenase (quinone) activity
Anae109_3277	COG2201	protein-glutamate methylesterase activity
Anae109_3284	COG1917	Cupin 2, conserved barrel domain protein
Anae109_3284	COG2207	Transcriptional regulator
Anae109_3288	COG1484	DNA-dependent DNA replication
Anae109_3304	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anae109_3310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Anae109_3314	COG0656	L-ascorbic acid biosynthetic process
Anae109_3316	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Anae109_3317	COG3959	Transketolase, thiamine diphosphate binding domain
Anae109_3321	COG0542	response to heat
Anae109_3323	COG0071	Belongs to the small heat shock protein (HSP20) family
Anae109_3326	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Anae109_3327	COG0589	response to stress
Anae109_3335	COG0693	protein deglycase activity
Anae109_3336	COG0071	Belongs to the small heat shock protein (HSP20) family
Anae109_3343	COG0006	proline dipeptidase activity
Anae109_3348	COG0604	alcohol dehydrogenase
Anae109_3350	COG0515	serine threonine protein kinase
Anae109_3350	COG2815	serine threonine protein kinase
Anae109_3352	COG0477	Major facilitator Superfamily
Anae109_3365	COG2204	response regulator
Anae109_3368	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Anae109_3375	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Anae109_3380	COG0488	(ABC) transporter
Anae109_3381	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Anae109_3396	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Anae109_3404	COG2204	response regulator
Anae109_3408	COG5000	phosphorelay sensor kinase activity
Anae109_3412	COG2252	PERMEase
Anae109_3413	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Anae109_3415	COG2521	methyltransferase
Anae109_3415	COG2136	Putative SAM-dependent methyltransferase
Anae109_3416	COG3279	Response regulator of the LytR AlgR family
Anae109_3417	COG3275	phosphorelay sensor kinase activity
Anae109_3421	COG0740	serine-type endopeptidase activity
Anae109_3422	COG0544	peptidyl-prolyl cis-trans isomerase activity
Anae109_3424	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Anae109_3425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Anae109_3427	COG0709	Synthesizes selenophosphate from selenide and ATP
Anae109_3435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Anae109_3437	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Anae109_3438	COG2234	aminopeptidase activity
Anae109_3442	COG0564	pseudouridine synthase activity
Anae109_3448	COG0739	heme binding
Anae109_3448	COG0741	lytic transglycosylase activity
Anae109_3448	COG1196	nuclear chromosome segregation
Anae109_3455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Anae109_3458	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Anae109_3460	COG1619	proteins homologs of microcin C7 resistance protein MccF
Anae109_3461	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Anae109_3462	COG0628	permease
Anae109_3463	COG0545	Peptidyl-prolyl cis-trans isomerase
Anae109_3464	COG0625	glutathione transferase activity
Anae109_3473	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Anae109_3479	COG2226	methyltransferase
Anae109_3487	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Anae109_3488	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Anae109_3496	COG0513	Belongs to the DEAD box helicase family
Anae109_3497	COG3123	guanosine phosphorylase activity
Anae109_3513	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Anae109_3518	COG0596	Alpha beta hydrolase
Anae109_3518	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Anae109_3518	COG2226	methyltransferase
Anae109_3520	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Anae109_3521	COG5557	Pfam Polysulphide reductase, NrfD
Anae109_3522	COG0437	4 iron, 4 sulfur cluster binding
Anae109_3523	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Anae109_3524	COG5557	Pfam Polysulphide reductase, NrfD
Anae109_3527	COG1360	Flagellar Motor Protein
Anae109_3532	COG2201	protein-glutamate methylesterase activity
Anae109_3543	COG1309	transcriptional regulator
Anae109_3545	COG2321	neutral zinc metallopeptidase
Anae109_3546	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Anae109_3549	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Anae109_3552	COG0587	DNA-directed DNA polymerase activity
Anae109_3555	COG2197	response regulator
Anae109_3556	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Anae109_3558	COG2815	serine threonine protein kinase
Anae109_3558	COG0515	serine threonine protein kinase
Anae109_3561	COG0156	8-amino-7-oxononanoate synthase activity
Anae109_3562	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Anae109_3565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Anae109_3566	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Anae109_3567	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Anae109_3575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Anae109_3576	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Anae109_3578	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Anae109_3579	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Anae109_3583	COG3706	GGDEF domain
Anae109_3583	COG0745	RESPONSE REGULATOR receiver
Anae109_3587	COG2096	Adenosyltransferase
Anae109_3589	COG0316	Belongs to the HesB IscA family
Anae109_3590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Anae109_3591	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Anae109_3593	COG0746	molybdenum cofactor guanylyltransferase activity
Anae109_3595	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Anae109_3596	COG1140	nitrate reductase beta subunit
Anae109_3598	COG2223	nitrite transmembrane transporter activity
Anae109_3601	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_3603	COG1648	precorrin-2 dehydrogenase activity
Anae109_3603	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Anae109_3604	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Anae109_3605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Anae109_3609	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Anae109_3614	COG1741	Belongs to the pirin family
Anae109_3617	COG0006	proline dipeptidase activity
Anae109_3618	COG3875	lactate racemase activity
Anae109_3626	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Anae109_3627	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Anae109_3628	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Anae109_3632	COG2205	protein histidine kinase activity
Anae109_3632	COG2202	Pas domain
Anae109_3635	COG0347	Belongs to the P(II) protein family
Anae109_3636	COG0004	ammonium transporteR
Anae109_3637	COG0438	transferase activity, transferring glycosyl groups
Anae109_3639	COG2353	YceI-like domain
Anae109_3640	COG0583	DNA-binding transcription factor activity
Anae109_3642	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Anae109_3643	COG0798	PFAM Bile acid sodium symporter
Anae109_3653	COG0622	Phosphoesterase
Anae109_3668	COG2197	response regulator
Anae109_3669	COG0596	Alpha beta hydrolase
Anae109_3669	COG0508	dehydrogenase complex catalyzes the overall conversion of
Anae109_3672	COG0519	Catalyzes the synthesis of GMP from XMP
Anae109_3672	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Anae109_3674	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
Anae109_3686	COG0739	heme binding
Anae109_3686	COG0741	lytic transglycosylase activity
Anae109_3686	COG1196	nuclear chromosome segregation
Anae109_3689	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Anae109_3696	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Anae109_3699	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Anae109_3700	COG1090	epimerase
Anae109_3703	COG0750	zinc metalloprotease
Anae109_3706	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Anae109_3711	COG1758	RNA polymerase activity
Anae109_3714	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Anae109_3715	COG0459	protein refolding
Anae109_3721	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Anae109_3723	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Anae109_3724	COG0045	succinate-CoA ligase (ADP-forming) activity
Anae109_3734	COG1380	Effector of murein hydrolase LrgA
Anae109_3735	COG1346	cytolysis
Anae109_3743	COG1183	phosphatidylcholine synthase activity
Anae109_3745	COG1058	Belongs to the CinA family
Anae109_3745	COG1546	Belongs to the CinA family
Anae109_3754	COG0702	epimerase
Anae109_3755	COG1573	uracil-dna glycosylase
Anae109_3758	COG1100	Small GTP-binding protein
Anae109_3760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Anae109_3761	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Anae109_3762	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Anae109_3763	COG0590	tRNA wobble adenosine to inosine editing
Anae109_3766	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Anae109_3767	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Anae109_3767	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Anae109_3769	COG0585	pseudouridine synthase activity
Anae109_3772	COG2261	transglycosylase associated protein
Anae109_3780	COG0651	ATP synthesis coupled electron transport
Anae109_3781	COG0651	ATP synthesis coupled electron transport
Anae109_3784	COG0651	ATP synthesis coupled electron transport
Anae109_3785	COG0649	NAD binding
Anae109_3786	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Anae109_3792	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Anae109_3793	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Anae109_3795	COG2205	protein histidine kinase activity
Anae109_3795	COG0784	Response regulator, receiver
Anae109_3799	COG0739	heme binding
Anae109_3803	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Anae109_3807	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Anae109_3808	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Anae109_3809	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Anae109_3810	COG1428	Deoxynucleoside kinase
Anae109_3813	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Anae109_3814	COG0745	RESPONSE REGULATOR receiver
Anae109_3814	COG3706	GGDEF domain
Anae109_3815	COG0484	heat shock protein binding
Anae109_3817	COG0631	protein serine/threonine phosphatase activity
Anae109_3818	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Anae109_3828	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Anae109_3832	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Anae109_3836	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Anae109_3837	COG0840	transmembrane signaling receptor activity
Anae109_3839	COG1902	pentaerythritol trinitrate reductase activity
Anae109_3844	COG0477	Major facilitator Superfamily
Anae109_3845	COG0626	cystathionine gamma-synthase activity
Anae109_3849	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Anae109_3851	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Anae109_3853	COG5002	protein histidine kinase activity
Anae109_3855	COG2267	carboxylic ester hydrolase activity
Anae109_3856	COG2226	methyltransferase
Anae109_3857	COG4191	Histidine kinase
Anae109_3858	COG0515	serine threonine protein kinase
Anae109_3861	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Anae109_3862	COG3437	response regulator, receiver
Anae109_3865	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Anae109_3868	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Anae109_3869	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Anae109_3873	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_3874	COG2001	Belongs to the MraZ family
Anae109_3876	COG0275	rRNA processing
Anae109_3879	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Anae109_3880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Anae109_3881	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Anae109_3882	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Anae109_3884	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Anae109_3885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Anae109_3886	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Anae109_3887	COG1181	Belongs to the D-alanine--D-alanine ligase family
Anae109_3891	COG2132	Multicopper oxidase
Anae109_3894	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Anae109_3904	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Anae109_3907	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Anae109_3908	COG1705	Flagellar rod assembly protein muramidase FlgJ
Anae109_3908	COG1388	LysM domain
Anae109_3909	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Anae109_3916	COG0793	Belongs to the peptidase S41A family
Anae109_3919	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Anae109_3925	COG2027	D-alanyl-D-alanine carboxypeptidase
Anae109_3926	COG0629	single-stranded DNA binding
Anae109_3927	COG2226	methyltransferase
Anae109_3933	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Anae109_3935	COG2003	Belongs to the UPF0758 family
Anae109_3937	COG2003	Belongs to the UPF0758 family
Anae109_3942	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Anae109_3943	COG2171	N-acyltransferase activity
Anae109_3944	COG0436	Aminotransferase
Anae109_3945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Anae109_3948	COG1192	Involved in chromosome partitioning
Anae109_3953	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Anae109_3954	COG0047	phosphoribosylformylglycinamidine synthase activity
Anae109_3956	COG0745	RESPONSE REGULATOR receiver
Anae109_3957	COG0312	modulator of DNA gyrase
Anae109_3958	COG0312	modulator of DNA gyrase
Anae109_3968	COG4964	Belongs to the GSP D family
Anae109_3974	COG4221	oxidoreductase activity
Anae109_3977	COG1595	DNA-templated transcription, initiation
Anae109_3978	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Anae109_3980	COG0582	viral genome integration into host DNA
Anae109_3989	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anae109_3992	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anae109_3993	COG1061	Type III restriction enzyme res subunit
Anae109_3996	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Anae109_3997	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
Anae109_4022	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Anae109_4025	COG0653	protein targeting
Anae109_4026	COG3459	Glycosyltransferase 36 associated
Anae109_4031	COG0840	transmembrane signaling receptor activity
Anae109_4035	COG1940	carbohydrate kinase activity
Anae109_4038	COG1793	dna ligase
Anae109_4040	COG3118	belongs to the thioredoxin family
Anae109_4042	COG1278	Cold shock
Anae109_4046	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Anae109_4047	COG0829	nickel cation binding
Anae109_4048	COG0832	Belongs to the urease beta subunit family
Anae109_4048	COG0831	urea catabolic process
Anae109_4049	COG0804	urea catabolic process
Anae109_4050	COG0830	nickel cation binding
Anae109_4051	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Anae109_4052	COG2818	Glycosylase
Anae109_4054	COG2205	protein histidine kinase activity
Anae109_4055	COG0730	response to heat
Anae109_4057	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Anae109_4061	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Anae109_4062	COG0488	(ABC) transporter
Anae109_4064	COG2815	serine threonine protein kinase
Anae109_4064	COG0515	serine threonine protein kinase
Anae109_4069	COG0589	response to stress
Anae109_4070	COG2032	superoxide dismutase activity
Anae109_4073	COG2193	ferroxidase activity
Anae109_4074	COG1472	Belongs to the glycosyl hydrolase 3 family
Anae109_4075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Anae109_4079	COG1657	PFAM Prenyltransferase squalene oxidase
Anae109_4080	COG1562	ergosterol biosynthetic process
Anae109_4081	COG3573	Dehydrogenase
Anae109_4082	COG1304	FMN binding
Anae109_4084	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anae109_4085	COG0626	cystathionine gamma-synthase activity
Anae109_4086	COG1295	ribonuclease BN
Anae109_4086	COG1959	2 iron, 2 sulfur cluster binding
Anae109_4089	COG1560	Kdo2-lipid A biosynthetic process
Anae109_4092	COG0439	Biotin carboxylase
Anae109_4093	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Anae109_4097	COG0501	Belongs to the peptidase M48B family
Anae109_4104	COG1918	ferrous iron import across plasma membrane
Anae109_4104	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Anae109_4105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Anae109_4105	COG1918	ferrous iron import across plasma membrane
Anae109_4109	COG0437	4 iron, 4 sulfur cluster binding
Anae109_4117	COG1278	Cold shock
Anae109_4121	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Anae109_4122	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Anae109_4125	COG0785	Cytochrome C biogenesis protein
Anae109_4127	COG0508	dehydrogenase complex catalyzes the overall conversion of
Anae109_4128	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Anae109_4139	COG0708	Exodeoxyribonuclease III
Anae109_4141	COG3706	GGDEF domain
Anae109_4143	COG1846	Transcriptional regulator
Anae109_4148	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Anae109_4149	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Anae109_4151	COG3852	Histidine kinase
Anae109_4156	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Anae109_4157	COG1921	L-seryl-tRNASec selenium transferase activity
Anae109_4160	COG5002	protein histidine kinase activity
Anae109_4162	COG1024	Enoyl-CoA hydratase
Anae109_4162	COG1250	3-hydroxyacyl-CoA dehydrogenase
Anae109_4163	COG0183	Belongs to the thiolase family
Anae109_4166	COG1131	(ABC) transporter
Anae109_4169	COG1234	tRNA 3'-trailer cleavage
Anae109_4173	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Anae109_4174	COG0515	serine threonine protein kinase
Anae109_4174	COG2815	serine threonine protein kinase
Anae109_4183	COG0318	PFAM AMP-dependent synthetase and ligase
Anae109_4184	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Anae109_4187	COG0542	response to heat
Anae109_4194	COG0142	geranyltranstransferase activity
Anae109_4198	COG0463	Glycosyl transferase, family 2
Anae109_4203	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Anae109_4204	COG2226	methyltransferase
Anae109_4205	COG0163	prenyltransferase activity
Anae109_4206	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Anae109_4207	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Anae109_4208	COG0402	S-adenosylhomocysteine deaminase activity
Anae109_4211	COG5002	protein histidine kinase activity
Anae109_4213	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Anae109_4214	COG2890	protein-(glutamine-N5) methyltransferase activity
Anae109_4215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Anae109_4216	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Anae109_4219	COG0582	viral genome integration into host DNA
Anae109_4223	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Anae109_4223	COG0116	Belongs to the methyltransferase superfamily
Anae109_4229	COG0464	growth
Anae109_4235	COG1966	Carbon starvation protein
Anae109_4239	COG0644	oxidoreductase
Anae109_4240	COG0492	ferredoxin-NADP+ reductase activity
Anae109_4242	COG3604	Transcriptional regulator
Anae109_4244	COG0531	amino acid
Anae109_4250	COG5002	protein histidine kinase activity
Anae109_4252	COG0745	RESPONSE REGULATOR receiver
Anae109_4253	COG4733	cellulase activity
Anae109_4253	COG5297	Belongs to the glycosyl hydrolase family 6
Anae109_4254	COG2839	Protein conserved in bacteria
Anae109_4256	COG3300	MHYT domain
Anae109_4256	COG5001	Diguanylate cyclase
Anae109_4257	COG2204	response regulator
Anae109_4258	COG2205	protein histidine kinase activity
Anae109_4259	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Anae109_4264	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Anae109_4267	COG2132	Multicopper oxidase
Anae109_4269	COG0129	dihydroxy-acid dehydratase activity
Anae109_4277	COG1960	acyl-CoA dehydrogenase activity
Anae109_4285	COG0745	RESPONSE REGULATOR receiver
Anae109_4290	COG0438	transferase activity, transferring glycosyl groups
Anae109_4296	COG1136	(ABC) transporter
Anae109_4296	COG0577	efflux transmembrane transporter activity
Anae109_4298	COG1136	(ABC) transporter
Anae109_4298	COG0577	efflux transmembrane transporter activity
Anae109_4299	COG0681	Belongs to the peptidase S26 family
Anae109_4301	COG1793	dna ligase
Anae109_4302	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Anae109_4306	COG3259	Nickel-dependent hydrogenase
Anae109_4310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Anae109_4311	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Anae109_4316	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Anae109_4318	COG0504	CTP synthase activity
Anae109_4319	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Anae109_4321	COG0564	pseudouridine synthase activity
Anae109_4323	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Anae109_4325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Anae109_4326	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Anae109_4327	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Anae109_4334	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Anae109_4336	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Anae109_4339	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Anae109_4343	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Anae109_4346	COG0713	ATP synthesis coupled electron transport
Anae109_4347	COG0839	Belongs to the complex I subunit 6 family
Anae109_4349	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Anae109_4350	COG2201	protein-glutamate methylesterase activity
Anae109_4354	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Anae109_4361	COG0784	Response regulator, receiver
Anae109_4361	COG2205	protein histidine kinase activity
Anae109_4362	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Anae109_4365	COG5002	protein histidine kinase activity
Anae109_4369	COG1193	negative regulation of DNA recombination
Anae109_4370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Anae109_4376	COG5002	protein histidine kinase activity
Anae109_4378	COG0306	phosphate transporter
Anae109_4379	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Anae109_4380	COG2094	Belongs to the DNA glycosylase MPG family
Anae109_4383	COG0469	pyruvate kinase activity
Anae109_4385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Anae109_4391	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Anae109_4395	COG2205	protein histidine kinase activity
Anae109_4398	COG4191	Histidine kinase
Anae109_4399	COG2204	response regulator
Anae109_4400	COG0174	glutamine synthetase
Anae109_4403	COG2046	Belongs to the sulfate adenylyltransferase family
Anae109_4404	COG1028	Short-chain dehydrogenase reductase Sdr
Anae109_4408	COG1595	DNA-templated transcription, initiation
Anae109_4410	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Anae109_4413	COG0411	ABC transporter
Anae109_4415	COG0559	Belongs to the binding-protein-dependent transport system permease family
Anae109_4417	COG0745	RESPONSE REGULATOR receiver
Anae109_4419	COG1472	Belongs to the glycosyl hydrolase 3 family
Anae109_4422	COG0714	Associated with various cellular activities
Anae109_4425	COG1595	DNA-templated transcription, initiation
Anae109_4428	COG3206	protein involved in exopolysaccharide biosynthesis
Anae109_4428	COG0489	protein tyrosine kinase activity
Anae109_4431	COG1132	(ABC) transporter
Anae109_4433	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Anae109_4435	COG0438	transferase activity, transferring glycosyl groups
Anae109_4436	COG0438	transferase activity, transferring glycosyl groups
Anae109_4440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Anae109_4441	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Anae109_4444	COG0463	Glycosyl transferase, family 2
Anae109_4451	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Anae109_4452	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Anae109_4457	COG3852	Histidine kinase
Anae109_4458	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Anae109_4459	COG1691	(AIR) carboxylase
Anae109_4461	COG0643	Histidine kinase
Anae109_4461	COG2198	Histidine kinase
Anae109_4462	COG2201	protein-glutamate methylesterase activity
Anae109_4463	COG0835	chemotaxis
Anae109_4466	COG2205	protein histidine kinase activity
Anae109_4466	COG2202	Pas domain
Anae109_4467	COG1100	Small GTP-binding protein
Anae109_4468	COG1199	ATP-dependent helicase activity
Anae109_4473	COG0484	heat shock protein binding
Anae109_4474	COG0443	Heat shock 70 kDa protein
Anae109_4475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Anae109_4476	COG1420	regulation of RNA biosynthetic process
Anae109_4479	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Anae109_4480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Anae109_4481	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Anae109_4482	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Anae109_4484	COG0012	GTP binding
Anae109_4485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Anae109_4486	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Anae109_4487	COG0356	it plays a direct role in the translocation of protons across the membrane
Anae109_4491	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Anae109_4494	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Anae109_4495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Anae109_4496	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Anae109_4497	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Anae109_4498	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Anae109_4499	COG0071	Belongs to the small heat shock protein (HSP20) family
Anae109_4501	COG1475	DNA binding
Anae109_4502	COG1192	Involved in chromosome partitioning
Anae109_4504	COG0357	Ribosomal RNA small subunit methyltransferase G
Anae109_4506	COG0706	membrane insertase activity
Anae109_4507	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Anae109_4508	COG0594	ribonuclease P activity