locus-tag class description AnaeK_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AnaeK_0005 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AnaeK_0008 ENOG4105DF6 Fe-S oxidoreductase AnaeK_0011 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AnaeK_0012 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AnaeK_0013 ENOG4107TEJ This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AnaeK_0014 ENOG4107XN1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AnaeK_0023 ENOG4105CUX Signal transduction histidine kinase AnaeK_0026 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AnaeK_0029 ENOG4105DYS nad(p)h dehydrogenase (quinone) AnaeK_0033 ENOG4108W2P Methyl-accepting chemotaxis AnaeK_0034 ENOG4105CHR reductase AnaeK_0037 ENOG4105CK7 Sodium proline symporter AnaeK_0040 ENOG4105DZS Phenylacetate-CoA ligase AnaeK_0042 ENOG4105DZS Phenylacetate-CoA ligase AnaeK_0045 ENOG4107RE7 phosphate butyryltransferase AnaeK_0046 ENOG4105CKM Branched-chain carboxylic acid kinase AnaeK_0049 ENOG4108VD1 dedA family AnaeK_0052 ENOG4105BZJ Electron transfer flavoprotein AnaeK_0053 ENOG4105C10 Electron transfer flavoprotein AnaeK_0054 ENOG4105C5X domain protein AnaeK_0055 ENOG4105EE5 Membrane protein terC AnaeK_0060 ENOG4107T0X DNA ligase AnaeK_0061 ENOG4105C34 Pseudouridine synthase AnaeK_0062 ENOG4108JQC penicillin-binding protein 1A AnaeK_0063 ENOG4107SDU Methyl-accepting chemotaxis AnaeK_0065 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AnaeK_0066 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AnaeK_0068 ENOG4105CHU acetyl-coa acetyltransferase AnaeK_0072 ENOG4105CCT upf0313 protein AnaeK_0075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AnaeK_0079 ENOG4105C0H protease AnaeK_0081 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AnaeK_0082 ENOG4108Z86 Glutamine amidotransferase AnaeK_0083 ENOG4105DWF phosphomethylpyrimidine kinase AnaeK_0085 ENOG4105CDU Replicative dna helicase AnaeK_0089 ENOG41067MG lrgb family AnaeK_0090 ENOG4105VAW lrga family AnaeK_0091 ENOG4105DND Transcriptional regulator AnaeK_0092 ENOG4105C3R Methionine synthase AnaeK_0096 ENOG4105D7A ATP-binding protein AnaeK_0097 ENOG4105BZU Histidine kinase AnaeK_0105 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AnaeK_0106 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AnaeK_0108 ENOG4105BZU Histidine kinase AnaeK_0109 ENOG4107RAN Peptidase, M16 AnaeK_0113 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_0114 ENOG4105BZU Histidine kinase AnaeK_0119 ENOG4105DFF Rod shape-determining protein mreb AnaeK_0120 ENOG4105DFF Rod shape-determining protein mreb AnaeK_0121 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AnaeK_0122 ENOG4105D9P serine threonine protein kinase AnaeK_0125 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AnaeK_0128 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AnaeK_0133 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AnaeK_0134 ENOG4108UGV hypoxanthine phosphoribosyltransferase AnaeK_0139 ENOG4105BZU Histidine kinase AnaeK_0146 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AnaeK_0148 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AnaeK_0151 ENOG410812K response regulator receiver protein AnaeK_0153 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AnaeK_0155 ENOG4108EQA pts system AnaeK_0158 ENOG4105F3R pts system mannose fructose sorbose family iid AnaeK_0159 ENOG41080Z8 PHOSPHOCARRIER protein AnaeK_0163 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AnaeK_0166 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AnaeK_0168 ENOG4105E2R ROK family AnaeK_0180 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AnaeK_0184 ENOG4105BZU Histidine kinase AnaeK_0188 ENOG4105F4X arginine AnaeK_0189 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AnaeK_0190 ENOG4107YU2 histidine triad (hIT) protein AnaeK_0193 ENOG4105KHN chorismate mutase AnaeK_0199 ENOG4105D49 3-dehydroquinate synthase AnaeK_0200 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AnaeK_0201 ENOG4105CKK Glycosyl transferase, family 2 AnaeK_0202 ENOG4108UQY Iron-storage protein AnaeK_0207 ENOG4105C34 Pseudouridine synthase AnaeK_0213 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AnaeK_0219 ENOG4107RGD Major Facilitator superfamily AnaeK_0224 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AnaeK_0228 ENOG4108Q5Y Membrane AnaeK_0230 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AnaeK_0245 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AnaeK_0246 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AnaeK_0251 ENOG4105HP8 regulator of competence-specific genes AnaeK_0254 ENOG4105EPD Oligopeptide transporter, Opt family AnaeK_0255 ENOG4108RQS Two component transcriptional regulator (Winged helix family AnaeK_0256 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AnaeK_0257 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AnaeK_0260 ENOG4107QX3 carboxylase AnaeK_0262 ENOG4105VEQ Cold shock protein AnaeK_0263 ENOG4107QWG 2-Nitropropane dioxygenase AnaeK_0265 ENOG4106HNH Acyl-transferase AnaeK_0267 ENOG4105BZU Histidine kinase AnaeK_0268 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AnaeK_0269 ENOG4107QSA Oxaloacetate decarboxylase AnaeK_0271 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AnaeK_0276 ENOG4105C34 Pseudouridine synthase AnaeK_0277 ENOG4108ZZF transport protein (ExbD) AnaeK_0278 ENOG4105SG9 biopolymer transport protein, ExbD AnaeK_0279 ENOG4105E02 MotA TolQ exbB proton channel AnaeK_0281 ENOG4108KPZ tonB-dependent Receptor AnaeK_0284 ENOG4105CE9 30S ribosomal protein S2 AnaeK_0287 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AnaeK_0288 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AnaeK_0289 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AnaeK_0290 ENOG4105DJ0 Poly(A) Polymerase AnaeK_0291 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AnaeK_0303 ENOG410902C phosphohistidine phosphatase, SixA AnaeK_0305 ENOG4107S1W 4-alpha-glucanotransferase AnaeK_0306 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AnaeK_0310 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein AnaeK_0312 ENOG4105BZU Histidine kinase AnaeK_0314 ENOG4105SXS Protein of unknown function (DUF456) AnaeK_0321 ENOG4105VSH 4-oxalocrotonate tautomerase AnaeK_0323 ENOG4105C5Q Transcriptional regulator AnaeK_0333 ENOG4107G87 m6 family metalloprotease domain protein AnaeK_0335 ENOG4105CD8 aminopeptidase N AnaeK_0336 ENOG4105E0X reductase AnaeK_0339 ENOG4105VG1 fes assembly suf system protein AnaeK_0343 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AnaeK_0350 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AnaeK_0356 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_0363 ENOG4107R7Y intracellular protease Pfpi family AnaeK_0367 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AnaeK_0369 ENOG4105HMI Membrane AnaeK_0370 ENOG4105DUM transcriptional regulator, lysR family AnaeK_0371 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) AnaeK_0372 ENOG4105BZU Histidine kinase AnaeK_0373 ENOG4105BZU Histidine kinase AnaeK_0375 ENOG4106237 Protein of unknown function (DUF330) AnaeK_0377 ENOG4105DHJ ABC, transporter AnaeK_0385 ENOG4108JU7 Transcriptional regulator AnaeK_0387 ENOG4105CHU acetyl-coa acetyltransferase AnaeK_0388 ENOG4105C1G acyl-Coa dehydrogenase AnaeK_0393 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AnaeK_0395 ENOG4105BZU Histidine kinase AnaeK_0398 ENOG4107Y3Y amidohydrolase AnaeK_0399 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AnaeK_0400 ENOG4105DVY radical SAM domain protein AnaeK_0401 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AnaeK_0402 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AnaeK_0403 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AnaeK_0405 ENOG4105C1V Peptidase, M16 AnaeK_0409 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AnaeK_0410 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 AnaeK_0413 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AnaeK_0414 ENOG4105C0H protease AnaeK_0417 ENOG4107RCI amp-dependent synthetase and ligase AnaeK_0419 ENOG4106B0W Curli production assembly transport component CsgG AnaeK_0425 ENOG4105DGW oligopeptidase A AnaeK_0429 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AnaeK_0432 ENOG4105CJ1 ABC, transporter AnaeK_0435 ENOG4105CHU acetyl-coa acetyltransferase AnaeK_0436 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AnaeK_0438 ENOG4105BZU Histidine kinase AnaeK_0439 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AnaeK_0441 ENOG4105D65 subunit l AnaeK_0442 ENOG4105C8S subunit m AnaeK_0446 ENOG4105BZU Histidine kinase AnaeK_0447 ENOG4105EM7 Selenocysteine-specific translation elongation factor AnaeK_0448 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AnaeK_0449 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AnaeK_0451 ENOG4105C1B dTDP-glucose 4-6-dehydratase AnaeK_0452 ENOG4105PSQ Acyl-transferase AnaeK_0454 ENOG41067TZ transcriptional regulator, MarR family AnaeK_0457 ENOG4105BZU Histidine kinase AnaeK_0460 ENOG41065RQ ADP-ribosylation crystallin J1 AnaeK_0467 ENOG4105EYH Exonuclease AnaeK_0468 ENOG4107RH8 nuclease SbcCD subunit D AnaeK_0475 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_0481 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AnaeK_0483 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AnaeK_0485 ENOG4105CPC Aldo Keto reductase AnaeK_0489 ENOG4105D5T phosphonate abc transporter AnaeK_0490 ENOG4105S7S phosphonate abc transporter AnaeK_0491 ENOG4107T9Q phosphonate abc transporter AnaeK_0497 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AnaeK_0501 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AnaeK_0502 ENOG4105QUH Domain of unknown function (DUF2088) AnaeK_0508 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF AnaeK_0511 ENOG4105DPX Hydrogenase, large subunit AnaeK_0512 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit AnaeK_0513 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_0514 ENOG4105E3S small subunit AnaeK_0520 ENOG4105KT7 mgtC SapB transporter AnaeK_0526 ENOG4108JJB ABC transporter AnaeK_0528 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AnaeK_0531 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AnaeK_0536 ENOG4108TQ9 Histidine kinase AnaeK_0537 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_0539 ENOG4105ES5 Histidine kinase AnaeK_0540 ENOG4105CVN desaturase AnaeK_0541 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AnaeK_0543 ENOG4105NXH GreA GreB family elongation factor AnaeK_0547 ENOG4105DU1 integral membrane protein, terc AnaeK_0549 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AnaeK_0550 ENOG4105BZS acriflavin resistance protein AnaeK_0551 ENOG4105C1P efflux transporter, rnd family, mfp subunit AnaeK_0552 ENOG4108Q5F Tetr family transcriptional regulator AnaeK_0553 ENOG4105CG3 alpha amylase, catalytic region AnaeK_0555 ENOG4105D74 hydrolase AnaeK_0557 ENOG4105WD1 Membrane AnaeK_0562 ENOG4108WIQ phosphoesterase PA-phosphatase related protein AnaeK_0563 ENOG4108SKZ Patatin-like phospholipase AnaeK_0565 ENOG4105CHM Aminotransferase AnaeK_0568 ENOG4105BZU Histidine kinase AnaeK_0570 ENOG4108JJB ABC transporter AnaeK_0571 ENOG4105VKD bioY protein AnaeK_0572 ENOG4105FBA Phospholipase Carboxylesterase AnaeK_0577 ENOG4107SET aldo keto reductase AnaeK_0583 ENOG4105EJC lysr family transcriptional regulator AnaeK_0585 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AnaeK_0590 ENOG4105CHR reductase AnaeK_0591 ENOG4105CBN LysR family transcriptional regulator AnaeK_0601 ENOG4107R3N Filamentation induced by cAMP protein fic AnaeK_0602 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AnaeK_0603 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AnaeK_0604 ENOG4105CI2 imidazolone-5-propionate hydrolase AnaeK_0605 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AnaeK_0608 ENOG4105JAB phenazine biosynthesis protein, phzf family AnaeK_0611 ENOG4105C1V Peptidase, M16 AnaeK_0612 ENOG4105BZU Histidine kinase AnaeK_0622 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AnaeK_0623 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AnaeK_0626 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AnaeK_0628 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AnaeK_0629 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AnaeK_0630 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AnaeK_0631 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AnaeK_0633 ENOG4105WVQ Fe-S assembly protein IscX AnaeK_0634 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AnaeK_0635 ENOG4105BZU Histidine kinase AnaeK_0636 ENOG4108V3W Chemotaxis protein, CheW AnaeK_0637 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_0638 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AnaeK_0640 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AnaeK_0643 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AnaeK_0646 ENOG4108QAF Methyl-accepting chemotaxis sensory transducer AnaeK_0647 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_0648 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AnaeK_0649 ENOG4105BZU Histidine kinase AnaeK_0650 ENOG4108UXN response regulator AnaeK_0651 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AnaeK_0652 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AnaeK_0654 ENOG4105KG3 cytidine deaminase AnaeK_0655 ENOG4105DTN riboflavin biosynthesis protein ribF AnaeK_0656 ENOG4107QHF type ii secretion system protein e AnaeK_0657 ENOG4105CZX twitching motility protein AnaeK_0659 ENOG4105BZU Histidine kinase AnaeK_0660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_0669 ENOG4106855 Competence protein AnaeK_0671 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AnaeK_0672 ENOG4105BZU Histidine kinase AnaeK_0673 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_0675 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AnaeK_0679 ENOG4105E4G Type IV pilus AnaeK_0682 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AnaeK_0683 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AnaeK_0684 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AnaeK_0688 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AnaeK_0689 ENOG4105C59 p-type ATPase AnaeK_0695 ENOG4105M8F Biopolymer transport protein exbD tolR AnaeK_0696 ENOG4105E02 MotA TolQ exbB proton channel AnaeK_0698 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AnaeK_0700 ENOG4105CAK Cell division ATP-binding protein ftsE AnaeK_0701 ENOG4105CRP Part of the ABC transporter FtsEX involved in AnaeK_0702 ENOG41063SB peptidase AnaeK_0703 ENOG4105CN1 protease AnaeK_0706 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AnaeK_0707 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AnaeK_0708 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AnaeK_0709 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_0714 ENOG4108WWZ General secretion pathway protein J AnaeK_0716 ENOG4108VAU general secretion pathway protein G AnaeK_0717 ENOG4108VAU general secretion pathway protein G AnaeK_0718 ENOG4105D7Q type ii secretion system AnaeK_0719 ENOG4107QHF type ii secretion system protein e AnaeK_0720 ENOG4105GVR general secretion pathway protein D AnaeK_0724 ENOG41082DI 50s ribosomal protein l31 AnaeK_0725 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AnaeK_0729 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AnaeK_0731 ENOG4105C03 ribonuclease AnaeK_0731 ENOG4105C03 ribonuclease AnaeK_0732 ENOG4107S2Z UPF0761 membrane protein AnaeK_0733 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AnaeK_0735 ENOG4105D00 flagellar biosynthetic protein flhB AnaeK_0738 ENOG4105CN7 Flagellar biosynthetic protein FliP AnaeK_0742 ENOG4108RBT type iii secretion AnaeK_0747 ENOG4105WH1 Two component transcriptional regulator luxr family AnaeK_0748 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AnaeK_0750 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AnaeK_0752 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AnaeK_0757 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AnaeK_0758 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_0760 ENOG4105CVJ phosphoglycerate mutase AnaeK_0761 ENOG4106HK8 GPR1 FUN34 yaaH family protein AnaeK_0762 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AnaeK_0764 ENOG4105C25 Primosomal protein n' AnaeK_0767 ENOG4105D1H recombination factor protein RarA AnaeK_0768 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AnaeK_0769 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AnaeK_0770 ENOG4108ZF3 Phosphatase AnaeK_0771 ENOG4105DR5 peptidase AnaeK_0773 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AnaeK_0778 ENOG4105DTT CRISPR-associated helicase, cas3 AnaeK_0784 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) AnaeK_0789 ENOG4108KPJ rna polymerase sigma factor AnaeK_0794 ENOG4105F4G Membrane AnaeK_0797 ENOG4107T8T UPF0173 metal-dependent hydrolase AnaeK_0799 ENOG4105DR5 peptidase AnaeK_0803 ENOG4108V1U phospholipid-binding protein AnaeK_0806 ENOG4105HEE Binding Domain protein AnaeK_0807 ENOG4105FR1 rard protein AnaeK_0808 ENOG4105Q9Y Universal stress protein AnaeK_0809 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AnaeK_0813 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AnaeK_0816 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AnaeK_0821 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AnaeK_0824 ENOG4108KXV response regulator AnaeK_0828 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AnaeK_0829 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AnaeK_0830 ENOG4105C7S Dehydrogenase AnaeK_0832 ENOG4105DQE DNA ligase AnaeK_0835 ENOG4105CQ7 ATP-dependent helicase AnaeK_0836 ENOG4105VN1 Heat shock protein AnaeK_0838 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AnaeK_0842 ENOG4105EMN RNA polymerase sigma factor AnaeK_0844 ENOG4107SFQ iron-sulfur binding AnaeK_0857 ENOG4105DIA mandelate racemase muconate lactonizing AnaeK_0858 ENOG4105CQB FAD linked oxidase domain protein AnaeK_0859 ENOG4108UVJ appr-1-p processing domain protein AnaeK_0860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_0861 ENOG4105CRE cytochrome C AnaeK_0864 ENOG4105GN4 DNA ligase AnaeK_0866 ENOG4105BZ8 glutamate synthase AnaeK_0869 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AnaeK_0871 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_0874 ENOG4105EEM helicase AnaeK_0875 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AnaeK_0876 ENOG4105C5H ABC transporter AnaeK_0877 ENOG4105C26 Dehydrogenase AnaeK_0880 ENOG4105BZU Histidine kinase AnaeK_0881 ENOG4105DA5 (ABC) transporter AnaeK_0882 ENOG4105E3A (ABC) transporter AnaeK_0884 ENOG4105C9U ATP-dependent DNA helicase RecQ AnaeK_0887 ENOG4108VWS Yaeq family AnaeK_0892 ENOG4105C9B Cysteine desulfurase AnaeK_0893 ENOG4108UNV SUF system FeS assembly protein, NifU family AnaeK_0897 ENOG4105CN1 protease AnaeK_0899 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_0902 ENOG4105WH1 Two component transcriptional regulator luxr family AnaeK_0908 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AnaeK_0912 ENOG4108V0P LemA family AnaeK_0917 ENOG4108JCI Transcriptional regulator AnaeK_0918 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AnaeK_0924 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AnaeK_0932 ENOG4105DQE DNA ligase AnaeK_0935 ENOG4105D64 Mechanosensitive ion channel AnaeK_0939 ENOG4105EEX Two component transcriptional regulator (Winged helix family AnaeK_0940 ENOG4105C08 Histidine kinase AnaeK_0942 ENOG4105C0X amino acid AnaeK_0947 ENOG4108SJC Membrane AnaeK_0950 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AnaeK_0953 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AnaeK_0956 ENOG410690C hydroxylamine oxidase AnaeK_0958 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AnaeK_0960 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AnaeK_0962 ENOG4107STQ Multicopper oxidase AnaeK_0973 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AnaeK_0974 ENOG4107YEM Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AnaeK_0976 ENOG4108YZ9 Urea amidohydrolase subunit gamma AnaeK_0977 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AnaeK_0978 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_0979 ENOG4105BZU Histidine kinase AnaeK_0983 ENOG4108IQK o-acetylhomoserine AnaeK_0986 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AnaeK_0987 ENOG4105D0U Arsenite-activated ATPase (ArsA) AnaeK_0990 ENOG4107QJE Chromosome Partitioning Protein AnaeK_0991 ENOG4105JQN Transcriptional regulator AnaeK_0992 ENOG4108YYC ycei family AnaeK_0993 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AnaeK_0994 ENOG4108NVM synthesis repressor PhaR AnaeK_0997 ENOG41063NY Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AnaeK_0998 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AnaeK_1004 ENOG4105C7Z Conserved Protein AnaeK_1011 ENOG4107SFI Major Facilitator superfamily AnaeK_1016 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AnaeK_1023 ENOG4105DQE DNA ligase AnaeK_1027 ENOG4105CYC Transferase AnaeK_1029 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AnaeK_1031 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AnaeK_1038 ENOG4105C2C drug resistance transporter, Bcr CflA AnaeK_1042 ENOG4105ERG peptidase m48, ste24p AnaeK_1045 ENOG4105VEQ Cold shock protein AnaeK_1048 ENOG4108R96 Methyltransferase, YaeB family AnaeK_1056 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AnaeK_1057 ENOG4105E0C molybdate abc transporter AnaeK_1058 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AnaeK_1062 ENOG4105UIB (ABC) transporter AnaeK_1063 ENOG4105C2J ABC transporter AnaeK_1064 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AnaeK_1075 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) AnaeK_1082 ENOG4108KB2 LysR family Transcriptional regulator AnaeK_1087 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AnaeK_1088 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AnaeK_1095 ENOG4105CHJ isochorismatase hydrolase AnaeK_1096 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AnaeK_1099 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AnaeK_1101 ENOG4105D48 metallophosphoesterase AnaeK_1103 ENOG4106PBJ Serine threonine-protein kinase Pkn6 AnaeK_1104 ENOG4105C3J Cysteine desulfurase AnaeK_1106 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AnaeK_1108 ENOG4105CM2 brancheD-chain amino acid aminotransferase AnaeK_1110 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AnaeK_1114 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_1116 ENOG4105C6Y Udp-glucose 6-dehydrogenase AnaeK_1120 ENOG4108IAJ Nad-dependent epimerase dehydratase AnaeK_1122 ENOG4105CK5 oxidoreductase AnaeK_1126 ENOG4105BZ1 (ABC) transporter AnaeK_1128 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_1129 ENOG4105EMU Dehydrogenase AnaeK_1130 ENOG4105ES5 Histidine kinase AnaeK_1133 ENOG4107QPV Serine Threonine protein kinase AnaeK_1135 ENOG4107RFW hydrolase family 57 AnaeK_1139 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AnaeK_1140 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AnaeK_1145 ENOG4105GYT Protein of unknown function (DUF1009) AnaeK_1147 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AnaeK_1148 ENOG4105D4P Coproporphyrinogen iii oxidase AnaeK_1149 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AnaeK_1151 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AnaeK_1153 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AnaeK_1154 ENOG41084YM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AnaeK_1155 ENOG4105ETX regulatoR AnaeK_1156 ENOG4105CTB Polyprenyl synthetase AnaeK_1158 ENOG4105DX0 Hemolysin A AnaeK_1165 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AnaeK_1171 ENOG4105BZU Histidine kinase AnaeK_1175 ENOG4105C0H protease AnaeK_1177 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AnaeK_1178 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AnaeK_1179 ENOG4105ETX regulatoR AnaeK_1181 ENOG4105DZP Membrane-associated zinc metalloprotease AnaeK_1182 ENOG4105NBF ammecr1 domain protein AnaeK_1183 ENOG4105E09 nadh pyrophosphatase AnaeK_1190 ENOG4105BZU Histidine kinase AnaeK_1192 ENOG4105C1G acyl-Coa dehydrogenase AnaeK_1193 ENOG4105VF7 tolerance protein AnaeK_1195 ENOG4108SPH protein kinase (EC 2.7.11.1) AnaeK_1196 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AnaeK_1197 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AnaeK_1199 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AnaeK_1200 ENOG4105NAU thioesterase Superfamily protein AnaeK_1201 ENOG4105C9K Endothelin-converting enzyme 1 AnaeK_1206 ENOG4105D3R alkyl hydroperoxide reductase AnaeK_1209 ENOG4107T4V d-proline reductase AnaeK_1214 ENOG4105CXV gliding motility protein AnaeK_1216 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AnaeK_1219 ENOG4105DMQ Methyltransferase AnaeK_1220 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_1221 ENOG4105DQ4 alcohol dehydrogenase AnaeK_1224 ENOG4105CEY Amp-dependent synthetase and ligase AnaeK_1225 ENOG4105QUH Domain of unknown function (DUF2088) AnaeK_1229 ENOG4108J2R molybdopterin oxidoreductase AnaeK_1230 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AnaeK_1234 ENOG4105C58 cytochrome c oxidase accessory protein ccog AnaeK_1249 ENOG4105CX6 glutaminyL-tRNA synthetase AnaeK_1254 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein AnaeK_1258 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AnaeK_1260 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_1261 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AnaeK_1263 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AnaeK_1265 ENOG4105KPV Transcriptional regulator AnaeK_1266 ENOG4105DB7 PHP domain protein AnaeK_1267 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AnaeK_1268 ENOG4105C8S subunit m AnaeK_1270 ENOG41080FQ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AnaeK_1272 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AnaeK_1273 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AnaeK_1275 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AnaeK_1277 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AnaeK_1280 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AnaeK_1283 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AnaeK_1284 ENOG41081QM NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AnaeK_1287 ENOG4105EYM Major Facilitator superfamily AnaeK_1288 ENOG4105DCG PHP domain protein AnaeK_1290 ENOG4105EPU Molybdenum cofactor synthesis domain protein AnaeK_1294 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AnaeK_1299 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AnaeK_1300 ENOG4105KME endoribonuclease L-psp AnaeK_1303 ENOG4107T5V SNARE associated Golgi AnaeK_1304 ENOG4105JFG SpoIID LytB domain protein AnaeK_1307 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AnaeK_1308 ENOG4105VIE preprotein translocase, subunit YajC AnaeK_1309 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AnaeK_1310 ENOG4107QT7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AnaeK_1313 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AnaeK_1314 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AnaeK_1317 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A AnaeK_1322 ENOG4107TE5 Lipid kinase AnaeK_1328 ENOG4105C0D helicase AnaeK_1333 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction AnaeK_1337 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AnaeK_1341 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AnaeK_1344 ENOG4105EIE fructose-bisphosphate aldolase AnaeK_1352 ENOG4105DFA alanine racemase domain protein AnaeK_1354 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AnaeK_1357 ENOG4105CJN penicillin-binding protein AnaeK_1358 ENOG4105CNI cell division protein FtsW AnaeK_1359 ENOG4105K63 Thioredoxin AnaeK_1362 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AnaeK_1363 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AnaeK_1366 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AnaeK_1370 ENOG4105C0B DNA polymerase III (alpha subunit) AnaeK_1379 ENOG4105DDR sarcosine oxidase (Beta subunit) AnaeK_1380 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AnaeK_1384 ENOG4107QQG Dehydrogenase AnaeK_1388 ENOG4106PBJ Serine threonine-protein kinase Pkn6 AnaeK_1390 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_1392 ENOG4105C12 Phosphoribosylglycinamide synthetase AnaeK_1398 ENOG4105EY8 ABC transporter AnaeK_1401 ENOG4105K64 Glycosyl transferase, family 2 AnaeK_1404 ENOG4105D3Q Sugar transferase AnaeK_1405 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AnaeK_1407 ENOG4105D52 delta-aminolevulinic acid dehydratase AnaeK_1410 ENOG4105CPF Cell wall formation (By similarity) AnaeK_1417 ENOG4105BZU Histidine kinase AnaeK_1421 ENOG4105DUM transcriptional regulator, lysR family AnaeK_1428 ENOG4105E3W Two component transcriptional regulator (Winged helix family AnaeK_1429 ENOG4105CVM Molybdenum cofactor synthesis domain protein AnaeK_1431 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AnaeK_1433 ENOG4105EJ9 Membrane AnaeK_1434 ENOG41080XQ Signal transduction protein with cbs domains AnaeK_1435 ENOG4108IV0 ABC, transporter AnaeK_1436 ENOG4105C0Z ABC transporter AnaeK_1437 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AnaeK_1438 ENOG4105C32 Amino acid ABC transporter (Permease) AnaeK_1441 ENOG4105C98 muts2 protein AnaeK_1448 ENOG4105EMN RNA polymerase sigma factor AnaeK_1452 ENOG4105EHZ conserved protein UCP016719 AnaeK_1456 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AnaeK_1461 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) AnaeK_1467 ENOG4105D78 K07001 NTE family protein AnaeK_1470 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AnaeK_1471 ENOG4105BZU Histidine kinase AnaeK_1474 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AnaeK_1475 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AnaeK_1476 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AnaeK_1480 ENOG4105CJR Integral membrane protein (MviN AnaeK_1486 ENOG4105EMN RNA polymerase sigma factor AnaeK_1488 ENOG4105DR4 Methyltransferase AnaeK_1492 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AnaeK_1494 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AnaeK_1496 ENOG4107QX8 SPFH domain, Band 7 family protein AnaeK_1498 ENOG4105D44 asparaginase AnaeK_1499 ENOG4105CHU acetyl-coa acetyltransferase AnaeK_1500 ENOG4105D6N CoA-transferase, subunit a AnaeK_1504 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AnaeK_1510 ENOG4105SG9 biopolymer transport protein, ExbD AnaeK_1511 ENOG4108PAU MotA TolQ exbB proton channel AnaeK_1512 ENOG4105D0M Protease HtpX homolog AnaeK_1516 ENOG4108Z0R Transferase AnaeK_1518 ENOG4108VD1 dedA family AnaeK_1519 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_1520 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AnaeK_1521 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AnaeK_1525 ENOG4106322 response regulator AnaeK_1527 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AnaeK_1529 ENOG4108P3C AnaeK_1531 ENOG4105FDK ABC transporter AnaeK_1535 ENOG4105CVR type I restriction-modification system AnaeK_1536 ENOG4107XZC Restriction modification system DNA (Specificity AnaeK_1537 ENOG4108F3G Type I restriction-modification system, R subunit AnaeK_1549 ENOG4105CMM transposase AnaeK_1552 ENOG4105D0C transport protein AnaeK_1558 ENOG4105CHM Aminotransferase AnaeK_1560 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AnaeK_1564 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AnaeK_1565 ENOG4108W6C Dehydrogenase AnaeK_1579 ENOG4105JQN Transcriptional regulator AnaeK_1583 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AnaeK_1589 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AnaeK_1590 ENOG4105W2Z cytochrome C, class I AnaeK_1595 ENOG4108XRS Monoheme cytochrome SoxX (Sulfur oxidation) AnaeK_1596 ENOG4105CGH 5'-nucleotidase AnaeK_1601 ENOG4105BZ9 Cytochrome C oxidase, subunit I AnaeK_1605 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AnaeK_1614 ENOG4105CKD glutathione-regulated potassium-efflux system protein AnaeK_1615 ENOG4105R8A Heat shock protein AnaeK_1623 ENOG4105EMN RNA polymerase sigma factor AnaeK_1629 ENOG4105C26 Dehydrogenase AnaeK_1630 ENOG4105MGM doxx family AnaeK_1634 ENOG4105BZU Histidine kinase AnaeK_1635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_1638 ENOG4105BZS acriflavin resistance protein AnaeK_1647 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AnaeK_1648 ENOG4105E9K Isocitrate dehydrogenase AnaeK_1649 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AnaeK_1654 ENOG4105C2M dna polymerase I AnaeK_1657 ENOG4108YZA Nitrogen regulatory protein pii AnaeK_1659 ENOG4105FG0 Nitroreductase AnaeK_1660 ENOG4105JQN Transcriptional regulator AnaeK_1661 ENOG4105EQ0 Major Facilitator superfamily AnaeK_1662 ENOG4107RSM transcriptional regulator AnaeK_1664 ENOG4105BZU Histidine kinase AnaeK_1666 ENOG4107T8Q Glycosyl transferase (Group 1 AnaeK_1669 ENOG4105EUB pirin domain protein AnaeK_1674 ENOG4108R4R Iron-regulated virulence regulatory protein AnaeK_1675 ENOG4105K63 Thioredoxin AnaeK_1680 ENOG4105DUM transcriptional regulator, lysR family AnaeK_1683 ENOG4105CRE cytochrome C AnaeK_1684 ENOG4108RAC Rubrerythrin AnaeK_1685 ENOG4105BZU Histidine kinase AnaeK_1691 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_1692 ENOG4108V3W Chemotaxis protein, CheW AnaeK_1695 ENOG4108594 Permease of the drug metabolite transporter AnaeK_1696 ENOG4108IV0 ABC, transporter AnaeK_1697 ENOG4105C0Z ABC transporter AnaeK_1699 ENOG4105CP9 extracellular ligand-binding receptor AnaeK_1700 ENOG4105EJ9 Membrane AnaeK_1702 ENOG4105E63 Pfam:DUF178 AnaeK_1704 ENOG4105DQQ Major facilitator superfamily MFS_1 AnaeK_1707 ENOG4108IUE nitrate reductase beta subunit AnaeK_1710 ENOG4105BZU Histidine kinase AnaeK_1719 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AnaeK_1721 ENOG4105C5H ABC transporter AnaeK_1724 ENOG4108R3E Dna-3-methyladenine glycosylase i AnaeK_1725 ENOG4105CEP NADH dehydrogenase AnaeK_1726 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AnaeK_1727 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_1728 ENOG4105BZU Histidine kinase AnaeK_1735 ENOG4107QIV Cytochrome c biogenesis protein AnaeK_1739 ENOG4105HDK L-asparaginase AnaeK_1742 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AnaeK_1744 ENOG4107QSN dihydrolipoamide acetyltransferase AnaeK_1745 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AnaeK_1751 ENOG4105D9P serine threonine protein kinase AnaeK_1755 ENOG4105CPC Aldo Keto reductase AnaeK_1756 ENOG4108RRZ Transcription elongation factor GreB AnaeK_1762 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AnaeK_1764 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AnaeK_1767 ENOG4105DCF alanine dehydrogenase AnaeK_1768 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AnaeK_1769 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AnaeK_1773 ENOG4105CRE cytochrome C AnaeK_1774 ENOG4105BZU Histidine kinase AnaeK_1775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_1782 ENOG4107EFR Flavocytochrome c AnaeK_1784 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AnaeK_1786 ENOG4107QRT dEAD DEAH box helicase AnaeK_1787 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AnaeK_1788 ENOG4105BZU Histidine kinase AnaeK_1790 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_1791 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) AnaeK_1792 ENOG4105CTQ phosphohexokinase AnaeK_1793 ENOG4105C28 cystathionine AnaeK_1797 ENOG4108URH decarboxylase AnaeK_1798 ENOG4105CIN aminoacyl-histidine dipeptidase AnaeK_1801 ENOG4105CPC Aldo Keto reductase AnaeK_1804 ENOG4105MPN Membrane AnaeK_1806 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AnaeK_1807 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AnaeK_1808 ENOG4105EXC Acyl-transferase AnaeK_1809 ENOG4107GFK fumarate AnaeK_1810 ENOG4107S4F acyltransferase, ws dgat mgat AnaeK_1816 ENOG4105C5H ABC transporter AnaeK_1819 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AnaeK_1821 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AnaeK_1823 ENOG4105DPN Oligoendopeptidase f AnaeK_1827 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AnaeK_1830 ENOG4105DWF phosphomethylpyrimidine kinase AnaeK_1832 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AnaeK_1835 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AnaeK_1836 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_1839 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AnaeK_1841 ENOG4105DN3 alpha-2-macroglobulin domain protein AnaeK_1842 ENOG4108JQB penicillin-binding protein 1C AnaeK_1847 ENOG4107QZ7 Cellulose synthase catalytic subunit AnaeK_1856 ENOG4105BZS acriflavin resistance protein AnaeK_1859 ENOG4105VW4 glutaredoxin 3 AnaeK_1860 ENOG4105D0M Protease HtpX homolog AnaeK_1861 ENOG41063Z6 transcriptional regulator, lysR family AnaeK_1862 ENOG4105DU1 integral membrane protein, terc AnaeK_1864 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AnaeK_1866 ENOG4105CIY formyltetrahydrofolate deformylase AnaeK_1869 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_1871 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_1872 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit AnaeK_1873 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AnaeK_1880 ENOG4105BZU Histidine kinase AnaeK_1881 ENOG4105WH1 Two component transcriptional regulator luxr family AnaeK_1884 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AnaeK_1885 ENOG4105BZU Histidine kinase AnaeK_1886 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_1887 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_1891 ENOG4105CI3 gtp-binding protein typa AnaeK_1894 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AnaeK_1897 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AnaeK_1906 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AnaeK_1907 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AnaeK_1912 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AnaeK_1913 ENOG4105EUJ GTP cyclohydrolase i AnaeK_1914 ENOG4105CHR reductase AnaeK_1915 ENOG4105CQB FAD linked oxidase domain protein AnaeK_1916 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AnaeK_1917 ENOG4105DQU oxidoreductase, subunit beta AnaeK_1919 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AnaeK_1920 ENOG4105DQU oxidoreductase, subunit beta AnaeK_1924 ENOG4105C1B dTDP-glucose 4-6-dehydratase AnaeK_1926 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AnaeK_1927 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AnaeK_1931 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AnaeK_1932 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AnaeK_1941 ENOG4108BAG 50s ribosomal protein l29 AnaeK_1950 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AnaeK_1953 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AnaeK_1957 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AnaeK_1958 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AnaeK_1964 ENOG4105VB6 UPF0109 protein AnaeK_1965 ENOG41082N4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AnaeK_1969 ENOG41082RQ UPF0102 protein AnaeK_1972 ENOG4105BZU Histidine kinase AnaeK_1973 ENOG4107SC1 transglycosylase AnaeK_1978 ENOG4105C34 Pseudouridine synthase AnaeK_1981 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AnaeK_1983 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AnaeK_1987 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AnaeK_1995 ENOG4105C34 Pseudouridine synthase AnaeK_1998 ENOG4105DHJ ABC, transporter AnaeK_2000 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AnaeK_2002 ENOG4108JQ1 Dehydrogenase AnaeK_2009 ENOG4105E39 Enoyl-CoA hydratase AnaeK_2030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AnaeK_2031 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AnaeK_2032 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AnaeK_2034 ENOG4105CPP Dehydrogenase, E1 component AnaeK_2037 ENOG4105CUZ uba thif-type nad fad binding protein AnaeK_2038 ENOG4107QN2 dihydrolipoyl dehydrogenase AnaeK_2039 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AnaeK_2040 ENOG4107QPV Serine Threonine protein kinase AnaeK_2041 ENOG4105EPD Oligopeptide transporter, Opt family AnaeK_2042 ENOG4105D9P serine threonine protein kinase AnaeK_2045 ENOG4105CZK Aspartate kinase AnaeK_2050 ENOG4105EFZ amidohydrolase AnaeK_2052 ENOG4105C4R Atp-dependent dna helicase AnaeK_2053 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_2058 ENOG4105BZU Histidine kinase AnaeK_2060 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AnaeK_2064 ENOG4105CY0 Metallo-Beta-Lactamase AnaeK_2068 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AnaeK_2069 ENOG4105C0H protease AnaeK_2074 ENOG4105D82 Glutamate dehydrogenase AnaeK_2078 ENOG4105WH1 Two component transcriptional regulator luxr family AnaeK_2081 ENOG4105BZU Histidine kinase AnaeK_2082 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2083 ENOG4108IJ0 Aspartate ammonia-lyase AnaeK_2084 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AnaeK_2085 ENOG4108Z9W Outer membrane porin AnaeK_2104 ENOG4105PGM cation diffusion facilitator family transporter AnaeK_2105 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AnaeK_2107 ENOG4108IJ6 ABC transporter AnaeK_2108 ENOG4105ECW sulfate abc transporter AnaeK_2109 ENOG4108I5D sulfate abc transporter AnaeK_2110 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AnaeK_2111 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AnaeK_2112 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AnaeK_2114 ENOG4106H78 methyltransferase AnaeK_2118 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AnaeK_2123 ENOG4105CHM Aminotransferase AnaeK_2126 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AnaeK_2127 ENOG4105CEV competence damage-inducible protein AnaeK_2137 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2139 ENOG4105D9P serine threonine protein kinase AnaeK_2141 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AnaeK_2150 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AnaeK_2152 ENOG410802X bacteriophage n4 adsorption protein b AnaeK_2160 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AnaeK_2161 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AnaeK_2164 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AnaeK_2165 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AnaeK_2168 ENOG4107RTD sua5 ycio yrdc ywlc family protein AnaeK_2169 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AnaeK_2170 ENOG4108Z4T Peptidase M50 AnaeK_2171 ENOG4105C31 Tryptophanyl-tRNA synthetase AnaeK_2172 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AnaeK_2173 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AnaeK_2174 ENOG4105FE9 pseudouridine synthase AnaeK_2178 ENOG4105EMN RNA polymerase sigma factor AnaeK_2180 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP AnaeK_2181 ENOG4105D7N magnesium and cobalt transport protein CorA AnaeK_2183 ENOG4105D1F ATP-binding protein AnaeK_2189 ENOG4105BZU Histidine kinase AnaeK_2190 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AnaeK_2191 ENOG4105E39 Enoyl-CoA hydratase AnaeK_2192 ENOG4105C1G acyl-Coa dehydrogenase AnaeK_2193 ENOG4105C1G acyl-Coa dehydrogenase AnaeK_2194 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AnaeK_2199 ENOG4108M19 cytochrome C AnaeK_2201 ENOG4105M6F mutator MutT protein AnaeK_2204 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AnaeK_2205 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AnaeK_2208 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AnaeK_2211 ENOG4105C1G acyl-Coa dehydrogenase AnaeK_2212 ENOG4107QX3 carboxylase AnaeK_2213 ENOG4105E39 Enoyl-CoA hydratase AnaeK_2220 ENOG4105CBT Fructose-1,6-bisphosphatase AnaeK_2222 ENOG4105D6E homoserine dehydrogenase AnaeK_2229 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AnaeK_2232 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AnaeK_2234 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AnaeK_2235 ENOG4108HMX isocitrate dehydrogenase (NADP) AnaeK_2237 ENOG4105BZU Histidine kinase AnaeK_2240 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AnaeK_2243 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AnaeK_2245 ENOG4105C3F Signal peptidase i AnaeK_2247 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AnaeK_2250 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AnaeK_2254 ENOG41080RH Thioredoxin AnaeK_2255 ENOG4108UYB regulatoR AnaeK_2256 ENOG4105BZU Histidine kinase AnaeK_2260 ENOG4107SC1 transglycosylase AnaeK_2265 ENOG4105ETX regulatoR AnaeK_2269 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_2276 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AnaeK_2279 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AnaeK_2280 ENOG4105C2N RNA methyltransferase TrmH family group 3 AnaeK_2282 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AnaeK_2283 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_2285 ENOG4108Z43 UPF0250 protein AnaeK_2286 ENOG4108IAB Phoh family AnaeK_2287 ENOG4105BZU Histidine kinase AnaeK_2290 ENOG4105C0R drug resistance transporter emrb qaca subfamily AnaeK_2291 ENOG4107Z3H Transcriptional regulator, TetR family AnaeK_2296 ENOG41079HR Phosphate-Selective Porin O and P AnaeK_2300 ENOG41090R7 Ferric uptake AnaeK_2309 ENOG4105BZU Histidine kinase AnaeK_2310 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2311 ENOG4105BZU Histidine kinase AnaeK_2312 ENOG4105PNM synthesis protein AnaeK_2317 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_2319 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AnaeK_2322 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AnaeK_2326 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AnaeK_2327 ENOG41081QJ UBA THIF-type NAD FAD binding AnaeK_2329 ENOG4105D06 uba thif-type nad fad binding protein AnaeK_2331 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_2333 ENOG4108Z4U Ferredoxin AnaeK_2335 ENOG4105CP7 Triose-phosphate isomerase AnaeK_2339 ENOG4105DZ0 fad dependent oxidoreductase AnaeK_2347 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AnaeK_2351 ENOG4105CAT Cytidine monophosphate kinase AnaeK_2353 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AnaeK_2359 ENOG4105CGP Urocanate hydratase AnaeK_2364 ENOG4105K8N protein family UPF0079, ATPase AnaeK_2365 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AnaeK_2367 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AnaeK_2368 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AnaeK_2370 ENOG4105C8B TIGR00159 family AnaeK_2372 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AnaeK_2373 ENOG4108Z6B deaminase AnaeK_2376 ENOG4105BZU Histidine kinase AnaeK_2379 ENOG4105K70 DNA-binding protein AnaeK_2380 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme AnaeK_2381 ENOG4108UYI beta-alanyl-CoA ammonia lyase AnaeK_2382 ENOG4107CHF 5,6-aminomutase beta subunit AnaeK_2384 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit AnaeK_2385 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AnaeK_2386 ENOG4105BZU Histidine kinase AnaeK_2387 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AnaeK_2390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2395 ENOG4105BZU Histidine kinase AnaeK_2396 ENOG4105BZU Histidine kinase AnaeK_2401 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_2406 ENOG4108YYC ycei family AnaeK_2407 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AnaeK_2411 ENOG4105BZU Histidine kinase AnaeK_2412 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2413 ENOG4107YZX Universal stress protein AnaeK_2418 ENOG4105BZP glycoside hydrolase 15-related AnaeK_2419 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AnaeK_2422 ENOG4108J5G 6-phosphogluconate dehydrogenase AnaeK_2423 ENOG4108IQE Amp-dependent synthetase and ligase AnaeK_2424 ENOG4108JZA Homocitrate synthase AnaeK_2428 ENOG4105K6H D-cysteine desulfhydrase AnaeK_2432 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AnaeK_2433 ENOG4105DNZ Alpha Beta Hydrolase AnaeK_2437 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_2449 ENOG41067HS methyltransferase AnaeK_2451 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AnaeK_2456 ENOG4108JUA Transcriptional regulator AnaeK_2457 ENOG4107QT6 homoserine O-acetyltransferase AnaeK_2458 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2461 ENOG4108ZC9 flagellar basal-body rod protein flgc AnaeK_2462 ENOG41084DA flagellar hook-basal body complex protein fliE AnaeK_2464 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AnaeK_2466 ENOG4108JIR Flagellum-specific ATP synthase AnaeK_2470 ENOG4105BZE flagellar hook protein, FlgE AnaeK_2472 ENOG4105E14 MotA TolQ exbB proton channel AnaeK_2473 ENOG4105ER2 Ompa motb domain protein AnaeK_2474 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AnaeK_2475 ENOG4105BZU Histidine kinase AnaeK_2476 ENOG4108V3W Chemotaxis protein, CheW AnaeK_2477 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_2478 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_2479 ENOG4108VYJ response regulator receiver protein AnaeK_2482 ENOG4108V3W Chemotaxis protein, CheW AnaeK_2483 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_2484 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AnaeK_2485 ENOG4108094 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AnaeK_2486 ENOG4105BZU Histidine kinase AnaeK_2487 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_2487 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_2489 ENOG4108MGY Histidine kinase AnaeK_2490 ENOG4108HU6 Metal dependent phosphohydrolase AnaeK_2492 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AnaeK_2493 ENOG4105DD5 Flagellar motor switch protein AnaeK_2495 ENOG4105CN7 Flagellar biosynthetic protein FliP AnaeK_2496 ENOG4105VS8 Flagellar biosynthetic protein fliq AnaeK_2497 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AnaeK_2498 ENOG4105D00 flagellar biosynthetic protein flhB AnaeK_2499 ENOG4105D7B Flagellar biosynthesis protein flha AnaeK_2500 ENOG4105FZW flagellar biosynthesis regulator FlhF AnaeK_2502 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_2505 ENOG4105KTQ flagellar basal-body rod protein AnaeK_2506 ENOG4105CGA flagellar basal-body rod protein FlgG AnaeK_2510 ENOG4105DR5 peptidase AnaeK_2515 ENOG4105I03 Flagellin AnaeK_2516 ENOG4107RT6 flagellar hook-associated AnaeK_2519 ENOG4105I03 Flagellin AnaeK_2521 ENOG4107TVC Glycosyl transferase, family 2 AnaeK_2524 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AnaeK_2525 ENOG4105CVM Molybdenum cofactor synthesis domain protein AnaeK_2527 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AnaeK_2528 ENOG41068KF Universal stress protein AnaeK_2529 ENOG4105CJW magnesium transporter AnaeK_2530 ENOG4108TQ9 Histidine kinase AnaeK_2531 ENOG4106322 response regulator AnaeK_2532 ENOG4105BZU Histidine kinase AnaeK_2533 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2542 ENOG4108RWI nicotinamidase AnaeK_2543 ENOG4105EQI Metal Dependent Phosphohydrolase AnaeK_2545 ENOG4105F8V Hydrolase, tatD family AnaeK_2546 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AnaeK_2548 ENOG4107QRG dna polymerase iii AnaeK_2550 ENOG4105C2M dna polymerase I AnaeK_2556 ENOG4105D7K pfkb domain protein AnaeK_2562 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AnaeK_2563 ENOG4105E4C Lytic transglycosylase catalytic AnaeK_2569 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AnaeK_2571 ENOG4105E55 glycerol-3-phosphate acyltransferase AnaeK_2573 ENOG4107TK4 histidinol-phosphate phosphatase AnaeK_2575 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AnaeK_2576 ENOG4107QHF type ii secretion system protein e AnaeK_2579 ENOG4105F0N pyrophosphate phospho-hydrolase AnaeK_2580 ENOG4105D7W serine acetyltransferase AnaeK_2583 ENOG4105NQN cytochrome C AnaeK_2586 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AnaeK_2588 ENOG4105VEQ Cold shock protein AnaeK_2591 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AnaeK_2593 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AnaeK_2603 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AnaeK_2606 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AnaeK_2607 ENOG4105IJJ transcriptional regulator, crp fnr family AnaeK_2609 ENOG4108V3E phosphoribosylglycinamide formyltransferase AnaeK_2612 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AnaeK_2615 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AnaeK_2618 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AnaeK_2620 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AnaeK_2623 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AnaeK_2627 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AnaeK_2629 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AnaeK_2630 ENOG4105VEQ Cold shock protein AnaeK_2634 ENOG4105HHA aminodeoxychorismate lyase AnaeK_2635 ENOG4105CYN Serine protein kinase AnaeK_2636 ENOG4106AKX UPF0229 protein AnaeK_2637 ENOG4105ED1 spovr family AnaeK_2641 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_2646 ENOG4108YZY peptidylprolyl cis-trans isomerase AnaeK_2648 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AnaeK_2649 ENOG4105CHR reductase AnaeK_2650 ENOG4105NZG Ferredoxin AnaeK_2654 ENOG4105JQZ Methyltransferase AnaeK_2661 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AnaeK_2663 ENOG4105CHR reductase AnaeK_2664 ENOG4105BZU Histidine kinase AnaeK_2675 ENOG4105BZU Histidine kinase AnaeK_2677 ENOG4108W2P Methyl-accepting chemotaxis AnaeK_2678 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_2679 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AnaeK_2680 ENOG4105BZU Histidine kinase AnaeK_2682 ENOG4107V40 secretion protein, HlyD family AnaeK_2686 ENOG4108IG5 Transcriptional regulator AnaeK_2690 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AnaeK_2691 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) AnaeK_2692 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AnaeK_2693 ENOG4105DSJ YicC domain protein AnaeK_2694 ENOG4105W49 UPF0434 protein AnaeK_2696 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AnaeK_2697 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AnaeK_2698 ENOG4105D1S lipid A biosynthesis AnaeK_2700 ENOG4105DKP glycosyl transferase, family 9 AnaeK_2701 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AnaeK_2703 ENOG4105BZ1 (ABC) transporter AnaeK_2704 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AnaeK_2705 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AnaeK_2708 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AnaeK_2709 ENOG41081FY multiple antibiotic resistance (MarC)-related AnaeK_2710 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AnaeK_2717 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_2718 ENOG4107QY8 reductase AnaeK_2720 ENOG4105BZU Histidine kinase AnaeK_2721 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AnaeK_2725 ENOG4108PQP glycosyl transferase group 1 AnaeK_2730 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AnaeK_2732 ENOG4105CHW UPF0052 protein AnaeK_2735 ENOG4107YJ4 chain length determinant protein AnaeK_2740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_2744 ENOG4105F0I Aminotransferase AnaeK_2747 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_2758 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AnaeK_2761 ENOG4105DTA methyltransferase AnaeK_2769 ENOG4105SYT Methylenetetrahydrofolate reductase AnaeK_2770 ENOG4108RRZ Transcription elongation factor GreB AnaeK_2777 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AnaeK_2782 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_2784 ENOG4105DBV ornithine carbamoyltransferase AnaeK_2785 ENOG4105C8Y Acetylornithine aminotransferase AnaeK_2786 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AnaeK_2788 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AnaeK_2792 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AnaeK_2794 ENOG4108WZM domain protein AnaeK_2796 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AnaeK_2798 ENOG4106EEU Response regulator receiver domain AnaeK_2800 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AnaeK_2803 ENOG4105E2K Glycosyl transferase (Group 1 AnaeK_2805 ENOG4107VGF ig domain protein group 2 domain protein AnaeK_2806 ENOG4105CZX twitching motility protein AnaeK_2809 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AnaeK_2812 ENOG4105CTJ Metal Dependent Phosphohydrolase AnaeK_2814 ENOG4108UJG AnaeK_2816 ENOG4105DXN mazG family AnaeK_2819 ENOG4105C8T Leucyl-tRNA synthetase AnaeK_2820 ENOG4105C5S asparaginyl-tRNA synthetase AnaeK_2821 ENOG4108VYJ response regulator receiver protein AnaeK_2822 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AnaeK_2823 ENOG4105BZU Histidine kinase AnaeK_2825 ENOG4108V3W Chemotaxis protein, CheW AnaeK_2828 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_2832 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AnaeK_2837 ENOG4108YZG isomerase AnaeK_2838 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AnaeK_2839 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AnaeK_2840 ENOG4105CHR reductase AnaeK_2841 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AnaeK_2842 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AnaeK_2844 ENOG41085D1 50S ribosomal protein L32 AnaeK_2846 ENOG4107ZHV Transcriptional regulator AnaeK_2851 ENOG4105VC4 domain protein AnaeK_2857 ENOG4105CPK Glycosyl transferase (Group 1 AnaeK_2858 ENOG4105D3Q Sugar transferase AnaeK_2861 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AnaeK_2864 ENOG4105CAQ asparagine synthetase AnaeK_2865 ENOG4107RMH nh(3)-dependent nad( ) synthetase AnaeK_2866 ENOG4105CEY Amp-dependent synthetase and ligase AnaeK_2879 ENOG4108PQP glycosyl transferase group 1 AnaeK_2880 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AnaeK_2884 ENOG4107T8Q Glycosyl transferase (Group 1 AnaeK_2885 ENOG4105BZ8 glutamate synthase AnaeK_2891 ENOG4105D9P serine threonine protein kinase AnaeK_2895 ENOG4105MIR Phenylalanine 4-monooxygenase AnaeK_2898 ENOG4105ETX regulatoR AnaeK_2900 ENOG4105BZU Histidine kinase AnaeK_2906 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AnaeK_2914 ENOG4107U53 septum site-determining protein minD AnaeK_2930 ENOG4105D0M Protease HtpX homolog AnaeK_2932 ENOG4105CB2 alcohol dehydrogenase AnaeK_2938 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AnaeK_2940 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AnaeK_2948 ENOG4105CK2 sodium dicarboxylate symporter AnaeK_2951 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AnaeK_2952 ENOG4105CQB FAD linked oxidase domain protein AnaeK_2953 ENOG4105CQB FAD linked oxidase domain protein AnaeK_2967 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AnaeK_2971 ENOG41089UC methyltransferase, type 11 AnaeK_2977 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AnaeK_2980 ENOG4105CVJ phosphoglycerate mutase AnaeK_2982 ENOG4105C6K Malic enzyme AnaeK_2983 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AnaeK_2984 ENOG4105K4T epimerase AnaeK_2987 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AnaeK_2989 ENOG4105CEY Amp-dependent synthetase and ligase AnaeK_2990 ENOG410841Q phosphoesterase PA-phosphatase related protein AnaeK_2991 ENOG4108IUK alpha amylase, catalytic AnaeK_2997 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AnaeK_3000 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AnaeK_3001 ENOG4105EB3 Histidine kinase AnaeK_3010 ENOG4105CND Glycosyl transferase, family 2 AnaeK_3011 ENOG4107BJW polysaccharide deacetylase AnaeK_3013 ENOG4106855 Competence protein AnaeK_3023 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AnaeK_3025 ENOG41088PD hydrolase AnaeK_3027 ENOG4105BZU Histidine kinase AnaeK_3028 ENOG4105BZU Histidine kinase AnaeK_3029 ENOG4105BZU Histidine kinase AnaeK_3041 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AnaeK_3042 ENOG4105C1J atp-dependent rna helicase AnaeK_3043 ENOG4105BZU Histidine kinase AnaeK_3046 ENOG4108I5G Major Facilitator superfamily AnaeK_3051 ENOG4105V2T cytochrome C AnaeK_3058 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_3059 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AnaeK_3060 ENOG4105DJY efflux transporter, rnd family, mfp subunit AnaeK_3061 ENOG4108HRK Histidine kinase AnaeK_3062 ENOG4108NEV two component transcriptional regulator, LytTR family AnaeK_3064 ENOG4105DAA L-lactate AnaeK_3066 ENOG4107QR9 Iron-sulfur cluster binding protein AnaeK_3069 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AnaeK_3080 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AnaeK_3086 ENOG4105EN6 Membrane AnaeK_3092 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AnaeK_3093 ENOG4105C5R Aminotransferase AnaeK_3094 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AnaeK_3096 ENOG4105CFF transcriptional regulator AnaeK_3097 ENOG4107QP3 malate synthase g AnaeK_3100 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) AnaeK_3101 ENOG4105CG3 alpha amylase, catalytic region AnaeK_3104 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AnaeK_3105 ENOG4105W8H transhydrogenase (subunit alpha AnaeK_3106 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AnaeK_3108 ENOG4105CEY Amp-dependent synthetase and ligase AnaeK_3109 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AnaeK_3111 ENOG4105DQU oxidoreductase, subunit beta AnaeK_3112 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AnaeK_3114 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AnaeK_3116 ENOG4105W3S hemerythrin-like, metal-binding protein AnaeK_3117 ENOG4105CQB FAD linked oxidase domain protein AnaeK_3118 ENOG4107R37 Glutamate dehydrogenase AnaeK_3121 ENOG4105C1G acyl-Coa dehydrogenase AnaeK_3124 ENOG4105CGD Nad-dependent epimerase dehydratase AnaeK_3126 ENOG4107SEY Conserved Protein AnaeK_3128 ENOG4107S2Z UPF0761 membrane protein AnaeK_3130 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AnaeK_3131 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AnaeK_3134 ENOG4105CPC Aldo Keto reductase AnaeK_3135 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AnaeK_3138 ENOG4105CPC Aldo Keto reductase AnaeK_3139 ENOG4107R7Y intracellular protease Pfpi family AnaeK_3142 ENOG4105C1J atp-dependent rna helicase AnaeK_3147 ENOG4108Z66 YbaK ebsC protein AnaeK_3148 ENOG4105ECJ Glycosyl Transferase AnaeK_3149 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AnaeK_3156 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AnaeK_3157 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AnaeK_3160 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AnaeK_3162 ENOG4108XZB Cytochrome c AnaeK_3172 ENOG4108XZB Cytochrome c AnaeK_3182 ENOG4105CHM Aminotransferase AnaeK_3183 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_3184 ENOG4105CDH Citrulline--aspartate ligase AnaeK_3187 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_3191 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_3195 ENOG4105ECR NmrA family AnaeK_3200 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AnaeK_3202 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB AnaeK_3204 ENOG4105D0B Nitrogenase protein alpha chain AnaeK_3205 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain AnaeK_3206 ENOG4105D0B Nitrogenase protein alpha chain AnaeK_3207 ENOG4108UR2 Nitrogen fixation protein NifX AnaeK_3210 ENOG4108K8Z nad( )--dinitrogen-reductase ADP-d-ribosyltransferase AnaeK_3211 ENOG4108JUA Transcriptional regulator AnaeK_3214 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family AnaeK_3217 ENOG4105DGW oligopeptidase A AnaeK_3218 ENOG4105BZU Histidine kinase AnaeK_3221 ENOG4105CJ1 ABC, transporter AnaeK_3222 ENOG4105CJ1 ABC, transporter AnaeK_3223 ENOG4107QWP ABC-2 type transporter AnaeK_3224 ENOG4107QWP ABC-2 type transporter AnaeK_3225 ENOG4108303 d-xylulose 5-phosphate d-fructose 6-phosphate phosphoketolase AnaeK_3226 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AnaeK_3236 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AnaeK_3237 ENOG4108KPJ rna polymerase sigma factor AnaeK_3239 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AnaeK_3240 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AnaeK_3241 ENOG4105BZU Histidine kinase AnaeK_3244 ENOG4108XFH Transcriptional regulator AnaeK_3245 ENOG4105F6U Short-chain dehydrogenase reductase Sdr AnaeK_3250 ENOG4105BZU Histidine kinase AnaeK_3252 ENOG4105C28 cystathionine AnaeK_3253 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_3259 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AnaeK_3265 ENOG4105D63 family UPF0324 AnaeK_3268 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AnaeK_3278 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_3283 ENOG4105DQ4 alcohol dehydrogenase AnaeK_3286 ENOG4105CJ1 ABC, transporter AnaeK_3287 ENOG4105EEQ Na H antiporter AnaeK_3288 ENOG4105EQ2 LysR family Transcriptional regulator AnaeK_3290 ENOG4105EN6 Membrane AnaeK_3292 ENOG4105VEQ Cold shock protein AnaeK_3293 ENOG4107TTQ Alpha beta hydrolase fold AnaeK_3296 ENOG4105E2V Glycosyltransferase 36 AnaeK_3298 ENOG4108IJ8 ABC transporter AnaeK_3299 ENOG4105E90 ABC transporter AnaeK_3304 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AnaeK_3306 ENOG4105C2C drug resistance transporter, Bcr CflA AnaeK_3307 ENOG4108YYC ycei family AnaeK_3312 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AnaeK_3314 ENOG4105BZP glycoside hydrolase 15-related AnaeK_3318 ENOG4105KJJ Uncharacterized ACR, COG1993 AnaeK_3320 ENOG4105NAE bifunctional deaminase-reductase domain protein AnaeK_3327 ENOG4105ETT transcriptional Regulator, LysR family AnaeK_3339 ENOG4108MR5 AnaeK_3350 ENOG4105EQ2 LysR family Transcriptional regulator AnaeK_3351 ENOG4105DQ4 alcohol dehydrogenase AnaeK_3354 ENOG4105E2A Dehydrogenase AnaeK_3356 ENOG4105CBN LysR family transcriptional regulator AnaeK_3357 ENOG4105CHR reductase AnaeK_3360 ENOG4105CPQ Dehydrogenase AnaeK_3362 ENOG4107RAQ aminopeptidase AnaeK_3368 ENOG4105CE1 Ferrous iron transport protein b AnaeK_3370 ENOG4105FRY Dehydrogenase AnaeK_3375 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AnaeK_3376 ENOG4107STQ Multicopper oxidase AnaeK_3378 ENOG4105C6T cysteine synthase AnaeK_3383 ENOG4108V0P LemA family AnaeK_3384 ENOG4105D0M Protease HtpX homolog AnaeK_3393 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AnaeK_3412 ENOG4105CUV Homoserine Kinase AnaeK_3418 ENOG4105KCK Peptidoglycan-associated lipoprotein AnaeK_3419 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_3420 ENOG4108JQC penicillin-binding protein 1A AnaeK_3423 ENOG4105ES5 Histidine kinase AnaeK_3426 ENOG4105C7N Xanthine uracil vitamin C permease AnaeK_3427 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AnaeK_3429 ENOG4107YX5 Pfam:DUF548 AnaeK_3432 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AnaeK_3433 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AnaeK_3434 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AnaeK_3436 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AnaeK_3438 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AnaeK_3440 ENOG4105CKK Glycosyl transferase, family 2 AnaeK_3442 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AnaeK_3444 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AnaeK_3448 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AnaeK_3450 ENOG4105CZX twitching motility protein AnaeK_3452 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AnaeK_3454 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AnaeK_3456 ENOG4105C4R Atp-dependent dna helicase AnaeK_3462 ENOG4105C34 Pseudouridine synthase AnaeK_3464 ENOG4107RAN Peptidase, M16 AnaeK_3466 ENOG4105BZU Histidine kinase AnaeK_3469 ENOG4105DR5 peptidase AnaeK_3470 ENOG4105ECY inositol monophosphatase AnaeK_3473 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AnaeK_3476 ENOG4105DFU Cell wall formation (By similarity) AnaeK_3478 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AnaeK_3479 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AnaeK_3480 ENOG4105C02 permease AnaeK_3481 ENOG4108V1T peptidylprolyl cis-trans isomerase AnaeK_3493 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AnaeK_3503 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AnaeK_3508 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AnaeK_3509 ENOG4105CM2 brancheD-chain amino acid aminotransferase AnaeK_3510 ENOG41090HR transcriptional regulator AnaeK_3514 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AnaeK_3522 ENOG4105NBK UPF0345 protein AnaeK_3525 ENOG4105C0B DNA polymerase III (alpha subunit) AnaeK_3528 ENOG4108S01 response regulator AnaeK_3529 ENOG4105C7B Threonine dehydratase AnaeK_3538 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AnaeK_3540 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AnaeK_3545 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AnaeK_3547 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AnaeK_3548 ENOG4105EHG Permease protein AnaeK_3549 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AnaeK_3552 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) AnaeK_3553 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AnaeK_3556 ENOG4105BZU Histidine kinase AnaeK_3557 ENOG4105BZU Histidine kinase AnaeK_3560 ENOG4108WBT adenosyltransferase AnaeK_3562 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AnaeK_3563 ENOG4105C5X domain protein AnaeK_3564 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AnaeK_3566 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AnaeK_3571 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AnaeK_3572 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AnaeK_3573 ENOG4105EUB pirin domain protein AnaeK_3583 ENOG4105VPX protein, conserved in bacteria AnaeK_3584 ENOG4105C59 p-type ATPase AnaeK_3587 ENOG4105CHP RNA polymerase AnaeK_3588 ENOG4105GRZ Ycii-related protein AnaeK_3592 ENOG4105E2K Glycosyl transferase (Group 1 AnaeK_3594 ENOG4105CPC Aldo Keto reductase AnaeK_3595 ENOG4105HEI LysR family (Transcriptional regulator AnaeK_3596 ENOG4105K63 Thioredoxin AnaeK_3598 ENOG4105CBD Diacylglycerol kinase AnaeK_3602 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_3603 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AnaeK_3606 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_3607 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_3609 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AnaeK_3612 ENOG4107QJZ Glycosyl transferase, family 2 AnaeK_3613 ENOG4107RIZ hflk protein AnaeK_3614 ENOG4105EPW hflc protein AnaeK_3618 ENOG4107EFR Flavocytochrome c AnaeK_3619 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AnaeK_3620 ENOG41065SU Two-component system sensor kinase AnaeK_3621 ENOG4108M3P Membrane AnaeK_3626 ENOG4105XUP Phage derived protein Gp49-like (DUF891) AnaeK_3629 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AnaeK_3631 ENOG4105E4C Lytic transglycosylase catalytic AnaeK_3632 ENOG4108IYU L-aspartate oxidase AnaeK_3634 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AnaeK_3638 ENOG4108EUD Lysophospholipase AnaeK_3644 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AnaeK_3647 ENOG41072GX Peptidase M22 Glycoprotease AnaeK_3648 ENOG4105DZP Membrane-associated zinc metalloprotease AnaeK_3650 ENOG4105KNE Phosphatidate cytidylyltransferase AnaeK_3651 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AnaeK_3652 ENOG4108PBA serine threonine protein kinase AnaeK_3655 ENOG4105CFH Aspartokinase AnaeK_3660 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AnaeK_3661 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AnaeK_3665 ENOG4108D1K outer membrane usher protein AnaeK_3669 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AnaeK_3671 ENOG4107RDT Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AnaeK_3681 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AnaeK_3682 ENOG4108ZAI phosphatidylglycerophosphatase a AnaeK_3687 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AnaeK_3688 ENOG4105C0P Mg chelatase subunit ChlI AnaeK_3691 ENOG4105CXV gliding motility protein AnaeK_3693 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AnaeK_3695 ENOG4105C6E dna polymerase iii AnaeK_3696 ENOG4108Z6B deaminase AnaeK_3699 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AnaeK_3703 ENOG4105UYK outer membrane protein a AnaeK_3704 ENOG4105Y3U Transglycosylase-associated protein AnaeK_3707 ENOG4107QPV Serine Threonine protein kinase AnaeK_3711 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AnaeK_3712 ENOG4108JPZ Monovalent cation H antiporter subunit D AnaeK_3713 ENOG4108JPZ Monovalent cation H antiporter subunit D AnaeK_3716 ENOG4108JPZ Monovalent cation H antiporter subunit D AnaeK_3717 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AnaeK_3718 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AnaeK_3722 ENOG4105DAP Nicotinate phosphoribosyltransferase AnaeK_3723 ENOG4107QM5 aconitate hydratase AnaeK_3729 ENOG4105DR5 peptidase AnaeK_3731 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AnaeK_3739 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AnaeK_3746 ENOG4105BZU Histidine kinase AnaeK_3747 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AnaeK_3749 ENOG4108ZF3 Phosphatase AnaeK_3750 ENOG4108S0S Nucleotidyl transferase AnaeK_3752 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AnaeK_3754 ENOG4107QN1 sodium solute AnaeK_3756 ENOG4105CSH Transporter AnaeK_3757 ENOG4105D9P serine threonine protein kinase AnaeK_3760 ENOG4107QN1 sodium solute AnaeK_3761 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_3764 ENOG4105C28 cystathionine AnaeK_3767 ENOG4105C0R drug resistance transporter emrb qaca subfamily AnaeK_3773 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AnaeK_3775 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_3776 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AnaeK_3777 ENOG4105DSQ Nitric oxide reductase AnaeK_3778 ENOG4105C8F Beta-lactamase domain protein AnaeK_3779 ENOG4105DR4 Methyltransferase AnaeK_3781 ENOG41062D9 Histidine kinase AnaeK_3783 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AnaeK_3785 ENOG4105BZU Histidine kinase AnaeK_3786 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_3787 ENOG4105C4M (Ubiquinol oxidase) subunit I AnaeK_3788 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AnaeK_3790 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AnaeK_3792 ENOG4105EMN RNA polymerase sigma factor AnaeK_3793 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AnaeK_3797 ENOG4108SPH protein kinase (EC 2.7.11.1) AnaeK_3799 ENOG4105E39 Enoyl-CoA hydratase AnaeK_3800 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AnaeK_3804 ENOG4105UYK outer membrane protein a AnaeK_3805 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AnaeK_3807 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AnaeK_3811 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AnaeK_3812 ENOG4108MG3 formate dehydrogenase AnaeK_3813 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) AnaeK_3816 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AnaeK_3821 ENOG4105CJN penicillin-binding protein AnaeK_3822 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AnaeK_3823 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AnaeK_3825 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AnaeK_3833 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AnaeK_3834 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AnaeK_3839 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AnaeK_3842 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AnaeK_3847 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AnaeK_3848 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_3853 ENOG4105CN1 protease AnaeK_3856 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AnaeK_3863 ENOG41090R7 Ferric uptake AnaeK_3864 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family AnaeK_3865 ENOG4108UUM single-stranded DNA-binding protein AnaeK_3869 ENOG4105MHT Transcriptional regulator, ARSR family AnaeK_3871 ENOG4105CIZ coA-substrate-specific enzyme activase AnaeK_3887 ENOG4105W5Q DNA repair protein (RadC AnaeK_3889 ENOG4108YYC ycei family AnaeK_3891 ENOG4107R4C succinyl-diaminopimelate desuccinylase AnaeK_3893 ENOG4105CHM Aminotransferase AnaeK_3898 ENOG4108Q9H CobQ/CobB/MinD/ParA nucleotide binding domain AnaeK_3902 ENOG4105C37 (CBS) domain AnaeK_3903 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AnaeK_3904 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AnaeK_3908 ENOG4105CMS peptidase U62, modulator of DNA gyrase AnaeK_3909 ENOG4105D1U peptidase U62 modulator of DNA gyrase AnaeK_3910 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 AnaeK_3912 ENOG4105EMU Dehydrogenase AnaeK_3918 ENOG41062D9 Histidine kinase AnaeK_3919 ENOG4108RQS Two component transcriptional regulator (Winged helix family AnaeK_3927 ENOG4108V5V Serine Threonine protein kinase AnaeK_3946 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_3949 ENOG4105CUX Signal transduction histidine kinase AnaeK_3950 ENOG4105DVF Cytosine-specific methyltransferase AnaeK_3961 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AnaeK_3981 ENOG4108KPJ rna polymerase sigma factor AnaeK_3982 ENOG4107QRT dEAD DEAH box helicase AnaeK_3984 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AnaeK_3986 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AnaeK_3991 ENOG4105EPH radical SAM domain protein AnaeK_3994 ENOG4105CRQ synthase (Component I) AnaeK_3995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AnaeK_3998 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_4001 ENOG4108JA1 polyketide synthase AnaeK_4003 ENOG4105D29 Helix-turn-helix type 11 domain protein AnaeK_4009 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AnaeK_4017 ENOG41080HT Transcriptional regulator, arsr family AnaeK_4018 ENOG4105D6J arsenicaL-resistance protein AnaeK_4019 ENOG4108UXE Protein tyrosine phosphatase AnaeK_4024 ENOG4105C5H ABC transporter AnaeK_4027 ENOG4105D25 secreted protein AnaeK_4030 ENOG4105D2S major facilitator superfamily AnaeK_4032 ENOG4107QSV RmuC domain protein AnaeK_4036 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AnaeK_4038 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AnaeK_4039 ENOG4105C6K Malic enzyme AnaeK_4043 ENOG4105CEP NADH dehydrogenase AnaeK_4048 ENOG4105C19 ABC transporter AnaeK_4050 ENOG4108DG9 Smr protein MutS2 AnaeK_4053 ENOG4105BZS acriflavin resistance protein AnaeK_4054 ENOG4105CJW magnesium transporter AnaeK_4059 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AnaeK_4060 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AnaeK_4061 ENOG4105C3M thioredoxin reductase AnaeK_4062 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AnaeK_4064 ENOG4105BZU Histidine kinase AnaeK_4067 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AnaeK_4069 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AnaeK_4070 ENOG4105M7V 2'-5' rna ligase AnaeK_4075 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AnaeK_4079 ENOG4105D1Z hydroxypyruvate reductase AnaeK_4086 ENOG4105ETX regulatoR AnaeK_4092 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AnaeK_4095 ENOG4105HFZ Membrane AnaeK_4097 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AnaeK_4100 ENOG4105C5H ABC transporter AnaeK_4101 ENOG4105F27 Major Facilitator AnaeK_4111 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AnaeK_4115 ENOG4108R5S membrane AnaeK_4118 ENOG4108UTW Plays a role in the regulation of phosphate uptake AnaeK_4119 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AnaeK_4120 ENOG4105E2Z phosphate ABC transporter (Permease AnaeK_4121 ENOG4105C8U phosphate abc transporter AnaeK_4122 ENOG4105CVA phosphate AnaeK_4124 ENOG4105BZU Histidine kinase AnaeK_4127 ENOG4105BZU Histidine kinase AnaeK_4128 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AnaeK_4137 ENOG4105DUX Transporter AnaeK_4138 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AnaeK_4139 ENOG4105M08 Membrane AnaeK_4140 ENOG41083V2 Pterin carbinolamine dehydratase AnaeK_4142 ENOG4107RN3 metallophosphoesterase AnaeK_4145 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AnaeK_4149 ENOG4105SG9 biopolymer transport protein, ExbD AnaeK_4150 ENOG4105E02 MotA TolQ exbB proton channel AnaeK_4154 ENOG410900P UPF0336 protein AnaeK_4156 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AnaeK_4159 ENOG4105CJN penicillin-binding protein AnaeK_4160 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AnaeK_4161 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AnaeK_4162 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AnaeK_4165 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AnaeK_4168 ENOG4105CRQ synthase (Component I) AnaeK_4169 ENOG4105DDQ anthranilate synthase AnaeK_4171 ENOG4105DK0 Indole-3-glycerol phosphate synthase AnaeK_4172 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AnaeK_4173 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AnaeK_4174 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AnaeK_4176 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase AnaeK_4184 ENOG4108ZT1 Transcriptional regulator AnaeK_4185 ENOG4108KTG Membrane protein, drug metabolite transporter AnaeK_4187 ENOG4105C2X Arabinose 5-phosphate isomerase AnaeK_4188 ENOG4105FB2 class II Aldolase AnaeK_4190 ENOG4105ERH Fumarylacetoacetate hydrolase AnaeK_4193 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AnaeK_4198 ENOG4108ZVT methylmalonyl-coA epimerase AnaeK_4200 ENOG4108JIC nucleoside recognition domain protein AnaeK_4210 ENOG4107QPH glycogen) synthase AnaeK_4220 ENOG4105CPK Glycosyl transferase (Group 1 AnaeK_4221 ENOG4108V5V Serine Threonine protein kinase AnaeK_4222 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AnaeK_4224 ENOG4105F0N pyrophosphate phospho-hydrolase AnaeK_4228 ENOG4105CIH Imidazole acetol-phosphate transaminase AnaeK_4232 ENOG4108IJF Heavy metal efflux pump, CzcA AnaeK_4238 ENOG4105KPY Small multidrug resistance protein AnaeK_4246 ENOG4105BZU Histidine kinase AnaeK_4249 ENOG4105C1G acyl-Coa dehydrogenase AnaeK_4252 ENOG4105BZU Histidine kinase AnaeK_4253 ENOG4105BZU Histidine kinase AnaeK_4258 ENOG4105CG3 alpha amylase, catalytic region AnaeK_4263 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AnaeK_4265 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AnaeK_4269 ENOG4107T9C Alpha amylase catalytic region AnaeK_4278 ENOG4105E2K Glycosyl transferase (Group 1 AnaeK_4286 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_4287 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_4288 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AnaeK_4289 ENOG4105C3F Signal peptidase i AnaeK_4296 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AnaeK_4298 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AnaeK_4299 ENOG4108IUZ ABC transporter AnaeK_4302 ENOG4105D1S lipid A biosynthesis AnaeK_4303 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AnaeK_4304 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AnaeK_4307 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AnaeK_4308 ENOG4105C34 Pseudouridine synthase AnaeK_4310 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AnaeK_4323 ENOG4105EJG cellulose synthase AnaeK_4324 ENOG4105CNU cell division protein FtsK AnaeK_4325 ENOG4108WHA ompa motb domain protein AnaeK_4330 ENOG4107YX3 NADH dehydrogenase subunit j AnaeK_4333 ENOG4105BZU Histidine kinase AnaeK_4334 ENOG41082BV acetyltransferase AnaeK_4338 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AnaeK_4339 ENOG4107R72 Ceramidase AnaeK_4345 ENOG4105BZU Histidine kinase AnaeK_4352 ENOG4105C98 muts2 protein AnaeK_4353 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AnaeK_4359 ENOG4105BZU Histidine kinase AnaeK_4361 ENOG4107QXV Phosphate transporter AnaeK_4362 ENOG4108QEV ribosomal RNA large subunit methyltransferase N AnaeK_4373 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AnaeK_4375 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AnaeK_4379 ENOG4105BZU Histidine kinase AnaeK_4381 ENOG4108YZA Nitrogen regulatory protein pii AnaeK_4382 ENOG4105BZU Histidine kinase AnaeK_4387 ENOG4105KPY Small multidrug resistance protein AnaeK_4391 ENOG4108IV0 ABC, transporter AnaeK_4392 ENOG4105C0Z ABC transporter AnaeK_4393 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AnaeK_4394 ENOG4105C32 Amino acid ABC transporter (Permease) AnaeK_4396 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AnaeK_4399 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AnaeK_4402 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AnaeK_4405 ENOG4105EMN RNA polymerase sigma factor AnaeK_4409 ENOG4105DAY polysaccharide export protein AnaeK_4413 ENOG4107T8Q Glycosyl transferase (Group 1 AnaeK_4415 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AnaeK_4417 ENOG4107T8Q Glycosyl transferase (Group 1 AnaeK_4419 ENOG4107QQG Dehydrogenase AnaeK_4420 ENOG4108IAJ Nad-dependent epimerase dehydratase AnaeK_4421 ENOG4108KMV Glycosyl transferase (Group 1 AnaeK_4424 ENOG4105C0K Gdp-mannose 4,6-dehydratase AnaeK_4426 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AnaeK_4429 ENOG4107QQG Dehydrogenase AnaeK_4432 ENOG4105CKK Glycosyl transferase, family 2 AnaeK_4437 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AnaeK_4441 ENOG4105C6Y Udp-glucose 6-dehydrogenase AnaeK_4442 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AnaeK_4443 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for AnaeK_4448 ENOG4105BZU Histidine kinase AnaeK_4449 ENOG4105C8M UPF0272 protein AnaeK_4450 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase AnaeK_4452 ENOG4105CBS Chea signal transduction histidine kinase AnaeK_4453 ENOG4107YTP response regulator receiver protein AnaeK_4454 ENOG4108ZGA chew protein AnaeK_4455 ENOG4105C8Q Methyl-accepting chemotaxis AnaeK_4456 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AnaeK_4457 ENOG4105BZU Histidine kinase AnaeK_4458 ENOG4105CXV gliding motility protein AnaeK_4459 ENOG4105DVT helicase AnaeK_4463 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AnaeK_4464 ENOG4105CFG Acts as a chaperone (By similarity) AnaeK_4468 ENOG4108JA2 transcriptioN-repair coupling factor AnaeK_4471 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AnaeK_4472 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AnaeK_4473 ENOG4105C3G gtp-binding protein AnaeK_4475 ENOG4105VHG atp synthase AnaeK_4482 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AnaeK_4484 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AnaeK_4488 ENOG4105VN1 Heat shock protein AnaeK_4490 ENOG4105FA0 parb-like partition protein AnaeK_4491 ENOG4107QJE Chromosome Partitioning Protein AnaeK_4497 ENOG41084M4 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)