locus-tag	class	description
DO83_00085	ENOG4105DTN	riboflavin biosynthesis protein ribF
DO83_00090	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
DO83_00095	ENOG4105SFS	phosphoesterase RecJ domain protein
DO83_00100	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
DO83_00105	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
DO83_00115	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
DO83_00120	ENOG4105CHV	Transcription elongation factor NusA
DO83_00135	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
DO83_00140	ENOG4105DZP	Membrane-associated zinc metalloprotease
DO83_00150	ENOG4105KNE	Phosphatidate cytidylyltransferase
DO83_00160	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
DO83_00165	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
DO83_00180	ENOG4105CIZ	coA-substrate-specific enzyme activase
DO83_00200	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
DO83_00210	ENOG4108ZP8	Acetolactate synthase small subunit
DO83_00215	ENOG4108RCF	TRANSCRIPTIONal
DO83_00220	ENOG4108KBE	Glycosyl transferase, family 2
DO83_00225	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DO83_00230	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DO83_00250	ENOG4107QQR	Sporulation
DO83_00255	ENOG4107QQR	Sporulation
DO83_00260	ENOG4107QQR	Sporulation
DO83_00270	ENOG4105EYH	Exonuclease
DO83_00275	ENOG4107RFY	SbcCD D subunit
DO83_00280	ENOG4105S1Z	Stage IV sporulation protein B
DO83_00285	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
DO83_00290	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
DO83_00295	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
DO83_00300	ENOG4105DX0	Hemolysin A
DO83_00305	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
DO83_00315	ENOG4108793	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
DO83_00320	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
DO83_00325	ENOG4105M7K	Involved in the transcription termination process (By similarity)
DO83_00330	ENOG4108ZSR	alkaline shock protein
DO83_00340	ENOG4108IA2	Sodium pantothenate symporter
DO83_00420	ENOG4105DA5	(ABC) transporter
DO83_00435	ENOG4105BZU	Histidine kinase
DO83_00460	ENOG4105UQX	Mate efflux family protein
DO83_00465	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
DO83_00475	ENOG4105BZU	Histidine kinase
DO83_00480	ENOG4105EFI	regulatoR
DO83_00485	ENOG4107RZC	phospholipase d
DO83_00500	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
DO83_00510	ENOG4107QHE	Choloylglycine hydrolase
DO83_00530	ENOG4105FA0	parb-like partition protein
DO83_00540	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
DO83_00565	ENOG4105VUF	Transcriptional regulator
DO83_00605	ENOG4105CDY	transcriptional regulatory protein
DO83_00610	ENOG4105C37	(CBS) domain
DO83_00615	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
DO83_00620	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
DO83_00625	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
DO83_00630	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
DO83_00635	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
DO83_00640	ENOG4105C5H	ABC transporter
DO83_00655	ENOG4105CSA	Coproporphyrinogen iii oxidase
DO83_00660	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
DO83_00670	ENOG4105CEF	Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity)
DO83_00675	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
DO83_00680	ENOG4105TQK	DNA polymerase iii, delta' subunit
DO83_00685	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
DO83_00695	ENOG4105BZU	Histidine kinase
DO83_00700	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DO83_00715	ENOG4105C8Y	Acetylornithine aminotransferase
DO83_00720	ENOG4105CAS	nag kinase
DO83_00725	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
DO83_00730	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
DO83_00760	ENOG4105CH7	arginosuccinase
DO83_00780	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
DO83_00790	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
DO83_00820	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
DO83_00825	ENOG4105CFG	Acts as a chaperone (By similarity)
DO83_00830	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DO83_00835	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
DO83_00850	ENOG4105N2W	Transcriptional regulator
DO83_00860	ENOG4105F1A	Pyruvate formate-lyase
DO83_00865	ENOG4105C6N	Formate acetyltransferase
DO83_00875	ENOG41082BM	Transcriptional regulator, arsr family
DO83_00905	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
DO83_00915	ENOG4105VUC	UPF0237 protein
DO83_00920	ENOG4105Q2H	domain protein
DO83_00925	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
DO83_00930	ENOG4105C2M	dna polymerase I
DO83_00940	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
DO83_00950	ENOG4108YZ4	nudix hydrolase
DO83_00965	ENOG4105C02	permease
DO83_00975	ENOG4105BZ8	glutamate synthase
DO83_01000	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
DO83_01010	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
DO83_01015	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
DO83_01020	ENOG4105DM4	PTS System
DO83_01030	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
DO83_01040	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DO83_01060	ENOG4105DUM	transcriptional regulator, lysR family
DO83_01075	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
DO83_01105	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
DO83_01110	ENOG4105QEK	Transcriptional regulator
DO83_01115	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
DO83_01120	ENOG4105C22	threonyL-tRNA synthetase
DO83_01135	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DO83_01140	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
DO83_01145	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
DO83_01150	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DO83_01155	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
DO83_01165	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
DO83_01170	ENOG4105DSJ	YicC domain protein
DO83_01180	ENOG4105EI2	Pseudouridine synthase
DO83_01190	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
DO83_01200	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
DO83_01210	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
DO83_01215	ENOG4105DXU	ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity)
DO83_01235	ENOG4105XT2	Transcriptional regulator
DO83_01245	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
DO83_01250	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
DO83_01255	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
DO83_01260	ENOG4105VFF	UPF0102 protein
DO83_01265	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
DO83_01275	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
DO83_01285	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
DO83_01295	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
DO83_01300	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
DO83_01305	ENOG4105CIN	aminoacyl-histidine dipeptidase
DO83_01320	ENOG4105EPD	Oligopeptide transporter, Opt family
DO83_01340	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
DO83_01350	ENOG4105XSJ	toxin secretion phage lysis holin
DO83_01365	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DO83_01470	ENOG4108TFU	terminase (Small subunit)
DO83_01640	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
DO83_01665	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
DO83_01670	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
DO83_01680	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
DO83_01720	ENOG4105C3S	Mate efflux family protein
DO83_01740	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
DO83_01755	ENOG4105CP7	Triose-phosphate isomerase
DO83_01770	ENOG4105EAM	Na Pi-cotransporter
DO83_01775	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
DO83_01785	ENOG4105K4H	Nlp p60 protein
DO83_01845	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
DO83_01855	ENOG4108J9M	Transporter
DO83_01865	ENOG4105VB6	UPF0109 protein
DO83_01870	ENOG4105K5M	30s ribosomal protein S16
DO83_01885	ENOG4105C5H	ABC transporter
DO83_01890	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
DO83_01900	ENOG4105BZU	Histidine kinase
DO83_01905	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DO83_01920	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
DO83_01925	ENOG4105CEV	competence damage-inducible protein
DO83_01930	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
DO83_01935	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
DO83_01950	ENOG4105CNU	cell division protein FtsK
DO83_01960	ENOG4105CVQ	ATP-dependent Clp protease, proteolytic subunit
DO83_01965	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
DO83_01975	ENOG4105CAT	Cytidine monophosphate kinase
DO83_01980	ENOG4105CBX	hi0933 family
DO83_01985	ENOG4105D7V	transposase
DO83_02000	ENOG4105CPC	Aldo Keto reductase
DO83_02005	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
DO83_02010	ENOG4105C3S	Mate efflux family protein
DO83_02015	ENOG4105ZXU	NLP P60 protein
DO83_02055	ENOG4105C8J	)-transporter
DO83_02065	ENOG4105VMP	Transcriptional regulator
DO83_02075	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
DO83_02080	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
DO83_02095	ENOG4105DG6	mannose-6-phosphate isomerase
DO83_02105	ENOG4105F3R	pts system mannose fructose sorbose family iid
DO83_02110	ENOG4105ETZ	PTS System
DO83_02120	ENOG4105CID	antiterminator
DO83_02125	ENOG4107U9T	Pfam:Ribonuclease_BN
DO83_02130	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
DO83_02135	ENOG4105DC7	peptidase M24
DO83_02140	ENOG4107R0W	ABC transporter
DO83_02145	ENOG4105E65	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DO83_02160	ENOG4105E66	phosphoriboisomerase A
DO83_02175	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
DO83_02180	ENOG4105DXX	methyltransferase
DO83_02185	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
DO83_02190	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
DO83_02200	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
DO83_02205	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DO83_02220	ENOG4108UMI	ABC transporter, permease
DO83_02225	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
DO83_02230	ENOG4105D01	(LipO)protein
DO83_02335	ENOG4105C4R	Atp-dependent dna helicase
DO83_02345	ENOG4105KGF	protein, YerC YecD
DO83_02350	ENOG4105BZG	amino acid carrier protein
DO83_02355	ENOG4105C8J	)-transporter
DO83_02360	ENOG4107QNG	Phosphoribosylglycinamide synthetase
DO83_02365	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
DO83_02370	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
DO83_02380	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
DO83_02410	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
DO83_02415	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
DO83_02420	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
DO83_02440	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
DO83_02445	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
DO83_02455	ENOG4105QHJ	toxin secretion phage lysis holin
DO83_02500	ENOG4105K4H	Nlp p60 protein
DO83_02600	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
DO83_02735	ENOG41067MG	lrgb family
DO83_02770	ENOG4105QIV	RNA polymerase
DO83_02775	ENOG4105C2N	RNA methyltransferase TrmH family group 3
DO83_02780	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DO83_02785	ENOG4105C8N	cysteinyl-tRNA synthetase
DO83_02790	ENOG4105D7W	serine acetyltransferase
DO83_02795	ENOG4105VKD	bioY protein
DO83_02805	ENOG4108UW5	maltose o-acetyltransferase
DO83_02840	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
DO83_02855	ENOG4105SYT	Methylenetetrahydrofolate reductase
DO83_02860	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
DO83_02870	ENOG4105BZ4	penicillin-binding protein
DO83_02880	ENOG4105CZ3	stage V sporulation protein ad
DO83_02885	ENOG41090VF	Stage v sporulation protein ac
DO83_02905	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
DO83_02945	ENOG4108ZJ4	polysaccharide deacetylase
DO83_02950	ENOG4105CE4	GlcNAc 6-P deacetylase
DO83_02960	ENOG4105C5Y	PTS System
DO83_02965	ENOG4105CID	antiterminator
DO83_03005	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
DO83_03010	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
DO83_03015	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
DO83_03030	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
DO83_03035	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
DO83_03040	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
DO83_03045	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
DO83_03060	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
DO83_03065	ENOG4105C1A	potassium transporter peripheral membrane
DO83_03070	ENOG41080HJ	6-phospho 3-hexuloisomerase
DO83_03075	ENOG4105DJV	ribulose-phosphate 3-epimerase
DO83_03090	ENOG4105DT3	PTS system, galactitol-specific IIc component
DO83_03100	ENOG4105ETD	TRANSCRIPTIONal
DO83_03120	ENOG4105WEF	catalase
DO83_03145	ENOG4105CK7	Sodium proline symporter
DO83_03150	ENOG41067S9	phage shock protein C, PspC
DO83_03170	ENOG4105F32	YngK protein
DO83_03190	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
DO83_03200	ENOG4105DFM	M18 family aminopeptidase
DO83_03215	ENOG4105E98	transcriptional regulator DeoR family
DO83_03225	ENOG4105CK5	oxidoreductase
DO83_03230	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
DO83_03235	ENOG41081I9	integral membrane protein
DO83_03255	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
DO83_03260	ENOG4105D7K	pfkb domain protein
DO83_03280	ENOG4105F0H	myo-inositol catabolism protein
DO83_03285	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
DO83_03295	ENOG4107VG4	Xylose isomerase domain protein TIM barrel
DO83_03300	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
DO83_03305	ENOG4105ETE	Transcriptional regulator (LacI family
DO83_03310	ENOG4105D2N	Aldolase
DO83_03325	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
DO83_03335	ENOG4105CK5	oxidoreductase
DO83_03345	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
DO83_03350	ENOG4105C1G	acyl-Coa dehydrogenase
DO83_03355	ENOG4105E39	Enoyl-CoA hydratase
DO83_03360	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
DO83_03365	ENOG4105CY2	Citrate transporter
DO83_03370	ENOG4105C10	Electron transfer flavoprotein
DO83_03375	ENOG4105BZJ	Electron transfer flavoprotein
DO83_03380	ENOG4105C10	Electron transfer flavoprotein
DO83_03385	ENOG4105BZJ	Electron transfer flavoprotein
DO83_03390	ENOG4105C1G	acyl-Coa dehydrogenase
DO83_03395	ENOG4105D7K	pfkb domain protein
DO83_03405	ENOG4105C5Y	PTS System
DO83_03415	ENOG4106D4I	domain protein
DO83_03420	ENOG4107RFY	SbcCD D subunit
DO83_03445	ENOG4105BZ1	(ABC) transporter
DO83_03470	ENOG4107QRS	glycosyltransferase group 2 family protein
DO83_03495	ENOG4107T8Q	Glycosyl transferase (Group 1
DO83_03575	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
DO83_03640	ENOG4105D3Q	Sugar transferase
DO83_03645	ENOG4105CHM	Aminotransferase
DO83_03670	ENOG4105CB5	ATP-dependent DNA helicase recG
DO83_03685	ENOG4105FDK	ABC transporter
DO83_03690	ENOG4105DSE	periplasmic solute binding protein
DO83_03710	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
DO83_03715	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
DO83_03730	ENOG4108R6K	riboflavin synthase, subunit alpha
DO83_03735	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
DO83_03745	ENOG41081VB	Hydrolase
DO83_03760	ENOG4105NTK	Transcriptional repressor Mpra
DO83_03765	ENOG4105C0B	DNA polymerase III (alpha subunit)
DO83_03775	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
DO83_03795	ENOG4105EWC	Purine nucleoside phosphorylase
DO83_03805	ENOG4105C9M	aspartyl-trna synthetase
DO83_03810	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
DO83_03815	ENOG4105C8V	SAICAR synthetase
DO83_03830	ENOG4105BZG	amino acid carrier protein
DO83_03840	ENOG4105BZ1	(ABC) transporter
DO83_03845	ENOG4105BZ1	(ABC) transporter
DO83_03855	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
DO83_03865	ENOG4105D1H	recombination factor protein RarA
DO83_03880	ENOG4105MT0	Sporulation transcriptional regulator spoiiid
DO83_03890	ENOG4105D7V	transposase
DO83_03900	ENOG4105CKI	cobalamin synthesis protein
DO83_03905	ENOG4107SCQ	Iron-containing alcohol dehydrogenase
DO83_03920	ENOG4105VEQ	Cold shock protein
DO83_03930	ENOG4108X4Q	Hydrolase
DO83_03940	ENOG4105EMN	RNA polymerase sigma factor
DO83_03955	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
DO83_03965	ENOG4108HKT	sucrose-6-phosphate hydrolase
DO83_03970	ENOG4105C5Y	PTS System
DO83_03980	ENOG4105ETE	Transcriptional regulator (LacI family
DO83_03985	ENOG4108Z0R	Transferase
DO83_04005	ENOG4105D9P	serine threonine protein kinase
DO83_04010	ENOG4108ZF3	Phosphatase
DO83_04015	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
DO83_04020	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
DO83_04025	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
DO83_04030	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
DO83_04035	ENOG4105C25	Primosomal protein n'
DO83_04040	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
DO83_04050	ENOG4108IUS	Transketolase
DO83_04055	ENOG4108HHA	Transketolase
DO83_04065	ENOG4105ETE	Transcriptional regulator (LacI family
DO83_04080	ENOG4107414	GntR family transcriptional regulator
DO83_04085	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
DO83_04090	ENOG4108Y83	glucose-6-phosphate isomerase
DO83_04095	ENOG4107QHI	-hydrogenase
DO83_04115	ENOG4105C0H	protease
DO83_04140	ENOG4107SJB	teichoic acid biosynthesis
DO83_04150	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
DO83_04170	ENOG4107SJB	teichoic acid biosynthesis
DO83_04175	ENOG4107SJB	teichoic acid biosynthesis
DO83_04205	ENOG410838F	Glycosyl transferase family 2
DO83_04220	ENOG4105CMR	udp-glucose 4-epimerase
DO83_04230	ENOG4105D5D	udp-galactopyranose mutase
DO83_04255	ENOG4105ER6	polysaccharide biosynthesis protein
DO83_04265	ENOG4105GH9	galactofuranosyltransferase
DO83_04280	ENOG4108UW5	maltose o-acetyltransferase
DO83_04300	ENOG4105D3Q	Sugar transferase
DO83_04340	ENOG4105WH5	Teichoic acid glycosylation protein
DO83_04345	ENOG4105CKK	Glycosyl transferase, family 2
DO83_04355	ENOG4105C8B	TIGR00159 family
DO83_04370	ENOG4105KY8	Rubrerythrin
DO83_04380	ENOG4105CQB	FAD linked oxidase domain protein
DO83_04385	ENOG4105C10	Electron transfer flavoprotein
DO83_04390	ENOG4105BZJ	Electron transfer flavoprotein
DO83_04395	ENOG41073TP	transcriptional regulator
DO83_04400	ENOG4108UT2	hemolysin iii
DO83_04425	ENOG4105DAP	Nicotinate phosphoribosyltransferase
DO83_04430	ENOG4105E9Q	Acyl-transferase
DO83_04455	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DO83_04460	ENOG4105BZU	Histidine kinase
DO83_04465	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
DO83_04475	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
DO83_04480	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
DO83_04495	ENOG4105C7J	ABC transporter, permease
DO83_04505	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
DO83_04510	ENOG4105C6K	Malic enzyme
DO83_04515	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
DO83_04520	ENOG4108HHA	Transketolase
DO83_04540	ENOG4105ETD	TRANSCRIPTIONal
DO83_04565	ENOG4105WG9	Conserved Protein
DO83_04575	ENOG4105BZJ	Electron transfer flavoprotein
DO83_04580	ENOG4105C1G	acyl-Coa dehydrogenase
DO83_04595	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
DO83_04600	ENOG4105BZ1	(ABC) transporter
DO83_04605	ENOG4108JJ9	ABC, transporter
DO83_04610	ENOG4105WD1	Membrane
DO83_04615	ENOG4105E0A	ABC, transporter
DO83_04710	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
DO83_04715	ENOG4105EMD	TRANSCRIPTIONal
DO83_04730	ENOG4105VYY	sporulation protein yabp
DO83_04735	ENOG41082I2	s4 domain protein
DO83_04740	ENOG4105K70	DNA-binding protein
DO83_04745	ENOG4105QNR	S1 RNA binding domain protein
DO83_04760	ENOG4105KFN	sortase, SrtB family
DO83_04770	ENOG4105KST	dependent repressor
DO83_04800	ENOG4108Z29	Flavodoxin
DO83_04810	ENOG4105CFG	Acts as a chaperone (By similarity)
DO83_04815	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
DO83_04830	ENOG4107RVG	penicillin-binding protein
DO83_04835	ENOG4107QPI	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
DO83_04845	ENOG4105C02	permease
DO83_04850	ENOG4105C5H	ABC transporter
DO83_04860	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
DO83_04885	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
DO83_04915	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
DO83_04920	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
DO83_04925	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
DO83_04930	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
DO83_04935	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
DO83_04940	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
DO83_04945	ENOG41085E0	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
DO83_04965	ENOG4108JPW	Aminotransferase
DO83_04985	ENOG4105DA5	(ABC) transporter
DO83_05005	ENOG4105DQ6	Transposase
DO83_05025	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
DO83_05030	ENOG4105ETE	Transcriptional regulator (LacI family
DO83_05035	ENOG41069M3	Transcriptional regulator
DO83_05040	ENOG4108UYI	beta-alanyl-CoA ammonia lyase
DO83_05045	ENOG4105SZ2	membrAne
DO83_05050	ENOG4105BZ8	glutamate synthase
DO83_05055	ENOG4107SJI	Dehydrogenase
DO83_05090	ENOG4108UYI	beta-alanyl-CoA ammonia lyase
DO83_05095	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
DO83_05100	ENOG4105C1G	acyl-Coa dehydrogenase
DO83_05105	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
DO83_05110	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
DO83_05115	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
DO83_05120	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
DO83_05130	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
DO83_05135	ENOG41082I9	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
DO83_05140	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
DO83_05145	ENOG4108YZG	isomerase
DO83_05150	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
DO83_05155	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
DO83_05165	ENOG4108S6Z	Negative regulator of genetic competence
DO83_05170	ENOG4107QW4	alcohol dehydrogenase
DO83_05180	ENOG4105CMT	Dihydroxyacetone kinase
DO83_05195	ENOG4105CMT	Dihydroxyacetone kinase
DO83_05200	ENOG4105DT3	PTS system, galactitol-specific IIc component
DO83_05225	ENOG4108RVA	ribokinase
DO83_05235	ENOG4105C7H	Helicase, RecD TraA family
DO83_05245	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
DO83_05265	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
DO83_05270	ENOG4105D7V	transposase
DO83_05285	ENOG4108V0P	LemA family
DO83_05325	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
DO83_05330	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
DO83_05335	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
DO83_05340	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DO83_05345	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DO83_05355	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
DO83_05360	ENOG4105D7V	transposase
DO83_05370	ENOG4105C8J	)-transporter
DO83_05385	ENOG4105C5I	Dehydrogenase
DO83_05390	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
DO83_05400	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
DO83_05410	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
DO83_05420	ENOG4105WDJ	50S ribosomal protein L33
DO83_05435	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
DO83_05450	ENOG4105P8F	nudix hydrolase
DO83_05465	ENOG4105BZ1	(ABC) transporter
DO83_05500	ENOG4105BZU	Histidine kinase
DO83_05510	ENOG4105BZU	Histidine kinase
DO83_05545	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
DO83_05585	ENOG4105K56	Transcriptional regulator
DO83_05590	ENOG4105KVH	Transcriptional regulator
DO83_05605	ENOG4108UW5	maltose o-acetyltransferase
DO83_05615	ENOG4105VUF	Transcriptional regulator
DO83_05625	ENOG41067QW	Transcriptional regulator
DO83_05635	ENOG4107UIE	peptidase
DO83_05655	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
DO83_05730	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DO83_05740	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DO83_05755	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
DO83_05770	ENOG4105BZU	Histidine kinase
DO83_05775	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DO83_05805	ENOG4105C19	ABC transporter
DO83_05815	ENOG4105CJZ	response regulator
DO83_05845	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
DO83_05885	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
DO83_05895	ENOG4105ETU	transcriptional activator (TenA
DO83_05950	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
DO83_05970	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
DO83_05990	ENOG4105DA5	(ABC) transporter
DO83_05995	ENOG4105FDP	GntR family transcriptional regulator
DO83_06060	ENOG4105C5H	ABC transporter
DO83_06140	ENOG4105W5Q	DNA repair protein (RadC
DO83_06200	ENOG4105CRK	lysyL-tRNA synthetase
DO83_06205	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
DO83_06225	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
DO83_06230	ENOG4105DBV	ornithine carbamoyltransferase
DO83_06255	ENOG4107ZYR	domain protein
DO83_06260	ENOG4105CZN	Potassium uptake protein
DO83_06270	ENOG4105C0B	DNA polymerase III (alpha subunit)
DO83_06275	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
DO83_06280	ENOG4105D22	carbon starvation protein
DO83_06285	ENOG4105C8J	)-transporter
DO83_06295	ENOG4107QP8	phosphohexose isomerase
DO83_06310	ENOG4105KRI	phosphocarrier protein (HPr
DO83_06315	ENOG4105CIE	May be required for sporulation (By similarity)
DO83_06325	ENOG4105D4A	Cell wall formation (By similarity)
DO83_06330	ENOG4105DKQ	ROK family
DO83_06335	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
DO83_06340	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
DO83_06350	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
DO83_06365	ENOG4105E1K	spore germination protein
DO83_06375	ENOG4105BZ1	(ABC) transporter
DO83_06390	ENOG4108ZJ4	polysaccharide deacetylase
DO83_06425	ENOG4105DRR	Transcriptional regulator, GntR family
DO83_06430	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
DO83_06435	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
DO83_06440	ENOG4105W42	Veg protein
DO83_06450	ENOG4105E98	transcriptional regulator DeoR family
DO83_06455	ENOG4105CPC	Aldo Keto reductase
DO83_06460	ENOG4107UH8	sugar kinase
DO83_06465	ENOG4105D2N	Aldolase
DO83_06470	ENOG4105CPQ	Dehydrogenase
DO83_06475	ENOG4107TE1	transport protein
DO83_06480	ENOG4105UP7	3-epimerase
DO83_06485	ENOG4105CPQ	Dehydrogenase
DO83_06490	ENOG4105CHR	reductase
DO83_06495	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
DO83_06520	ENOG4105BZ1	(ABC) transporter
DO83_06525	ENOG4105BZ1	(ABC) transporter
DO83_06535	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
DO83_06540	ENOG4106CC8	Bacterial inner membrane protein
DO83_06555	ENOG4108J5H	Homocysteine s-methyltransferase
DO83_06580	ENOG4105UQX	Mate efflux family protein
DO83_06585	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
DO83_06590	ENOG4105F3R	pts system mannose fructose sorbose family iid
DO83_06595	ENOG4105ETZ	PTS System
DO83_06620	ENOG4105CHM	Aminotransferase
DO83_06625	ENOG4108ZB6	transcriptional regulator AsnC family
DO83_06630	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
DO83_06640	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
DO83_06645	ENOG410667J	hydrolase
DO83_06650	ENOG410667J	hydrolase
DO83_06670	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DO83_06680	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
DO83_06685	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
DO83_06690	ENOG4105EQI	Metal Dependent Phosphohydrolase
DO83_06695	ENOG4105C98	muts2 protein
DO83_06705	ENOG4105CTS	PTS system mannitol-specific
DO83_06710	ENOG4108KHP	Diguanylate cyclase
DO83_06715	ENOG4108KF8	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
DO83_06720	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
DO83_06725	ENOG4105C5Y	PTS System
DO83_06730	ENOG4108Q3X	Transcriptional regulator
DO83_06735	ENOG4105QEK	Transcriptional regulator
DO83_06740	ENOG4105CI1	PTS System
DO83_06745	ENOG4105F8D	glycoside hydrolase family 4
DO83_06750	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
DO83_06755	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
DO83_06765	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
DO83_06770	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
DO83_06780	ENOG4105K59	histidine triad (HIT) protein
DO83_06785	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
DO83_06790	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
DO83_06795	ENOG4105C6E	dna polymerase iii
DO83_06805	ENOG4107ZXI	Rhomboid family
DO83_06860	ENOG4105PTM	secreted protein
DO83_06870	ENOG4108RT7	Glycosyl transferase, family 2
DO83_06875	ENOG4107R37	Glutamate dehydrogenase
DO83_06900	ENOG4105CJ1	ABC, transporter
DO83_06905	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
DO83_06920	ENOG4105KTH	gatB Yqey
DO83_06940	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
DO83_06950	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
DO83_06965	ENOG41080HI	glycine oxidase
DO83_06970	ENOG41060NJ	transcriptional regulator
DO83_06975	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
DO83_06985	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
DO83_06990	ENOG4105ETD	TRANSCRIPTIONal
DO83_07055	ENOG4108ZDA	Sporulation protein YyaC
DO83_07090	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
DO83_07100	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
DO83_07115	ENOG4105HEE	Binding Domain protein
DO83_07155	ENOG4105DE4	1-phosphofructokinase
DO83_07160	ENOG4105E98	transcriptional regulator DeoR family
DO83_07170	ENOG4105C19	ABC transporter
DO83_07175	ENOG4105W06	Cupin 2, conserved barrel domain protein
DO83_07180	ENOG4107RU2	Histidinol phosphate phosphatase, HisJ family
DO83_07185	ENOG4105EWM	Histidine kinase
DO83_07190	ENOG4105CJZ	response regulator
DO83_07195	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
DO83_07205	ENOG4105FA0	parb-like partition protein
DO83_07210	ENOG4107QJE	Chromosome Partitioning Protein
DO83_07215	ENOG4105C75	arginyL-tRNA synthetase
DO83_07225	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
DO83_07230	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
DO83_07235	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
DO83_07245	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
DO83_07250	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
DO83_07255	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
DO83_07260	ENOG4105VG0	50S ribosomal protein l34
DO83_07265	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
DO83_07270	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
DO83_07275	ENOG4105WQ3	Rna-binding protein
DO83_07280	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
DO83_07285	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DO83_07290	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DO83_07295	ENOG4106DSS	Tartrate dehydratase subunit alpha
DO83_07355	ENOG4105CXN	decarboxylase
DO83_07360	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
DO83_07365	ENOG4105FA2	dna polymerase iii
DO83_07370	ENOG4105MA4	psp1 domain protein
DO83_07375	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
DO83_07380	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
DO83_07385	ENOG4105KRN	Transcriptional regulator, abrb family
DO83_07400	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
DO83_07405	ENOG4105GVJ	transcriptional regulator
DO83_07425	ENOG4107STF	Involved in phosphonate degradation (By similarity)
DO83_07430	ENOG4105CHH	sulfate transporter
DO83_07440	ENOG4108JIC	nucleoside recognition domain protein
DO83_07455	ENOG4105F8V	Hydrolase, tatD family
DO83_07460	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
DO83_07470	ENOG4108Z6B	deaminase
DO83_07495	ENOG4105BZ4	penicillin-binding protein
DO83_07500	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
DO83_07515	ENOG4105DFU	Cell wall formation (By similarity)
DO83_07520	ENOG4105K4W	Could be involved in septation (By similarity)
DO83_07530	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
DO83_07540	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
DO83_07550	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
DO83_07555	ENOG4105CDU	Replicative dna helicase
DO83_07560	ENOG4105MJ2	Competence protein
DO83_07565	ENOG4105CEN	a g-specific adenine glycosylase
DO83_07570	ENOG4108HW3	(ABC) transporter
DO83_07575	ENOG4105EAD	ABC transporter
DO83_07590	ENOG4106PMH	Extracellular solute-binding protein family 3
DO83_07630	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
DO83_07635	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
DO83_07640	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
DO83_07645	ENOG4105D2N	Aldolase
DO83_07650	ENOG4106KNT	transcriptional regulator
DO83_07660	ENOG4105DM4	PTS System
DO83_07665	ENOG4105DM4	PTS System
DO83_07685	ENOG4107R4J	Chloride channel
DO83_07690	ENOG4105M6F	mutator MutT protein
DO83_07705	ENOG4105D6U	Sodium Glutamate Symporter
DO83_07715	ENOG4105VUF	Transcriptional regulator
DO83_07720	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
DO83_07725	ENOG4105CTQ	phosphohexokinase
DO83_07730	ENOG4105DKT	Transcriptional regulator
DO83_07735	ENOG4105DXH	Alcohol dehydrogenase zinc-binding domain protein
DO83_07740	ENOG4105D2N	Aldolase
DO83_07745	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
DO83_07760	ENOG4108SPH	protein kinase (EC 2.7.11.1)
DO83_07785	ENOG4105CA9	Pyruvate kinase
DO83_07790	ENOG4105CG3	alpha amylase, catalytic region
DO83_07800	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
DO83_07835	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
DO83_07840	ENOG4105UQX	Mate efflux family protein
DO83_07915	ENOG4105CUZ	uba thif-type nad fad binding protein
DO83_07920	ENOG4108UMN	azlc family
DO83_07925	ENOG4105KMT	branched-chain amino acid
DO83_07930	ENOG4105C28	cystathionine
DO83_07940	ENOG4105C6T	cysteine synthase
DO83_07945	ENOG4105D06	uba thif-type nad fad binding protein
DO83_07960	ENOG4108YRF	PTS System
DO83_07965	ENOG4105DM4	PTS System
DO83_07970	ENOG4105D2N	Aldolase
DO83_07975	ENOG4105D2N	Aldolase
DO83_07980	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
DO83_07985	ENOG4106KNT	transcriptional regulator
DO83_07995	ENOG4105F8D	glycoside hydrolase family 4
DO83_08000	ENOG4105F8D	glycoside hydrolase family 4
DO83_08005	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
DO83_08025	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
DO83_08030	ENOG4105US7	Histidine kinase
DO83_08065	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
DO83_08075	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
DO83_08090	ENOG4107QMU	Mate efflux family protein
DO83_08115	ENOG4105CMU	LysR family (Transcriptional regulator
DO83_08150	ENOG4105CZX	twitching motility protein
DO83_08165	ENOG4107YV9	domain protein
DO83_08170	ENOG4105C7W	Xanthine dehydrogenase
DO83_08180	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
DO83_08185	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
DO83_08190	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
DO83_08195	ENOG4108JA2	transcriptioN-repair coupling factor
DO83_08210	ENOG4108JQ1	Dehydrogenase
DO83_08215	ENOG4108XBJ	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
DO83_08230	ENOG4105DT3	PTS system, galactitol-specific IIc component
DO83_08235	ENOG4108MDK	Dehydrogenase
DO83_08265	ENOG4105FDP	GntR family transcriptional regulator
DO83_08285	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
DO83_08290	ENOG4105DM4	PTS System
DO83_08325	ENOG4107QM2	Aldo Keto reductase
DO83_08330	ENOG4108ZQX	ybak prolyl-trna synthetase
DO83_08365	ENOG4107ZYR	domain protein
DO83_08370	ENOG4105C08	Histidine kinase
DO83_08375	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
DO83_08380	ENOG4105EJQ	L-serine dehydratase
DO83_08390	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
DO83_08395	ENOG4107V2S	Transcriptional regulator
DO83_08420	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
DO83_08430	ENOG4105C0A	alcohol dehydrogenase
DO83_08435	ENOG4105EMD	TRANSCRIPTIONal
DO83_08440	ENOG41080QX	K07048 phosphotriesterase-related protein
DO83_08455	ENOG4105DT3	PTS system, galactitol-specific IIc component
DO83_08460	ENOG4105CXK	mandelate racemase muconate lactonizing
DO83_08465	ENOG4108UHU	Aldolase
DO83_08475	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
DO83_08480	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
DO83_08485	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
DO83_08490	ENOG4105CPF	Cell wall formation (By similarity)
DO83_08495	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
DO83_08505	ENOG4105C08	Histidine kinase
DO83_08510	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
DO83_08520	ENOG4105BZU	Histidine kinase
DO83_08545	ENOG4107Z1W	Fructose transport system kinase
DO83_08575	ENOG4105EJQ	L-serine dehydratase
DO83_08580	ENOG4106N3A	copper homeostasis protein cutc
DO83_08585	ENOG4105C09	Bile acid
DO83_08595	ENOG4105CKK	Glycosyl transferase, family 2
DO83_08600	ENOG4105EJV	Membrane
DO83_08605	ENOG4105ECB	domain protein
DO83_08630	ENOG4105DY9	regulatoR
DO83_08655	ENOG4105J7I	hydrolase
DO83_08660	ENOG4107ZE5	PPIases accelerate the folding of proteins
DO83_08665	ENOG4105HHA	aminodeoxychorismate lyase
DO83_08675	ENOG4105C9M	aspartyl-trna synthetase
DO83_08685	ENOG4105YHU	PTS system
DO83_08690	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
DO83_08695	ENOG4105D2N	Aldolase
DO83_08715	ENOG4105ETZ	PTS System
DO83_08720	ENOG4105F3R	pts system mannose fructose sorbose family iid
DO83_08725	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
DO83_08730	ENOG4108FN7	Aldo keto reductase
DO83_08735	ENOG4105DQ6	Transposase
DO83_08760	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
DO83_08765	ENOG4105CZV	ABC transporter
DO83_08780	ENOG4105EAM	Na Pi-cotransporter
DO83_08810	ENOG4105CMG	Carbohydrate kinase
DO83_08820	ENOG4105VCQ	rubredoxin
DO83_08830	ENOG4108RAC	Rubrerythrin
DO83_08835	ENOG4105CB5	ATP-dependent DNA helicase recG
DO83_08840	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
DO83_08850	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
DO83_08855	ENOG4105G3A	stage ii sporulation protein e
DO83_08860	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
DO83_08865	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
DO83_08905	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
DO83_08910	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
DO83_08915	ENOG4105CHR	reductase
DO83_08920	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
DO83_08930	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
DO83_08935	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
DO83_08945	ENOG4108FRU	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
DO83_08955	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
DO83_08960	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
DO83_08975	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DO83_08985	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
DO83_08995	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
DO83_09000	ENOG41082SA	50s ribosomal protein l29
DO83_09005	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
DO83_09010	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
DO83_09015	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
DO83_09025	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
DO83_09030	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
DO83_09035	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
DO83_09040	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
DO83_09045	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
DO83_09050	ENOG4105VPB	50S ribosomal protein L30
DO83_09060	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
DO83_09075	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
DO83_09080	ENOG41067V7	50S ribosomal protein L36
DO83_09090	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
DO83_09095	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
DO83_09100	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DO83_09105	ENOG4108ZT0	50S ribosomal protein l17
DO83_09110	ENOG4108JJB	ABC transporter
DO83_09115	ENOG4108JJB	ABC transporter
DO83_09120	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
DO83_09125	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
DO83_09135	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
DO83_09150	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
DO83_09175	ENOG4105CNW	domain protein
DO83_09185	ENOG41082XB	radical SAM domain protein
DO83_09210	ENOG4105C3M	thioredoxin reductase
DO83_09215	ENOG4105MS2	ribosomal subunit Interface protein
DO83_09220	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
DO83_09225	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
DO83_09230	ENOG41090I5	UPF0735 ACT domain-containing protein
DO83_09235	ENOG4105E3H	phosphoglycerate mutase
DO83_09245	ENOG4107YWA	deoxycytidylate deaminase
DO83_09255	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
DO83_09265	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
DO83_09270	ENOG4105CAK	Cell division ATP-binding protein ftsE
DO83_09275	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
DO83_09290	ENOG4105C3J	Cysteine desulfurase
DO83_09370	ENOG4105K4H	Nlp p60 protein
DO83_09415	ENOG4106128	DNA-binding helix-turn-helix protein
DO83_09420	ENOG4106BHR	ftsk SpoIIIE family protein
DO83_09470	ENOG4105E98	transcriptional regulator DeoR family
DO83_09475	ENOG4105C6N	Formate acetyltransferase
DO83_09480	ENOG4105F1A	Pyruvate formate-lyase
DO83_09485	ENOG4108M14	stage v sporulation protein t
DO83_09495	ENOG4105K8N	protein family UPF0079, ATPase
DO83_09500	ENOG41072GX	Peptidase M22 Glycoprotease
DO83_09505	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
DO83_09510	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
DO83_09520	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
DO83_09615	ENOG4105DM4	PTS System
DO83_09620	ENOG4108YRF	PTS System
DO83_09625	ENOG4105DM4	PTS System
DO83_09635	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
DO83_09645	ENOG4108YZG	isomerase
DO83_09655	ENOG4105CMT	Dihydroxyacetone kinase
DO83_09670	ENOG4105DVE	abc transporter atp-binding protein
DO83_09690	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
DO83_09705	ENOG4105DXH	Alcohol dehydrogenase zinc-binding domain protein
DO83_09710	ENOG4105C59	p-type ATPase
DO83_09715	ENOG4107YCR	Transcriptional regulator, ARSR family
DO83_09720	ENOG4105D6E	homoserine dehydrogenase
DO83_09725	ENOG4105YA8	Transcriptional regulator
DO83_09755	ENOG4105CRQ	synthase (Component I)
DO83_09760	ENOG4105DDQ	anthranilate synthase
DO83_09765	ENOG4105DK0	Indole-3-glycerol phosphate synthase
DO83_09775	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
DO83_09780	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
DO83_09785	ENOG4105CHM	Aminotransferase
DO83_09790	ENOG4105CIH	Imidazole acetol-phosphate transaminase
DO83_09800	ENOG4108REF	Sporulation integral membrane protein ytvi
DO83_09805	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
DO83_09850	ENOG4105T4X	n-acetylmuramoyl-l-alanine amidase
DO83_09855	ENOG4107Y5K	Resolvase
DO83_09865	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
DO83_10010	ENOG4108N9J	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
DO83_10085	ENOG41066EA	baseplate J family protein
DO83_10150	ENOG4108Z66	YbaK ebsC protein
DO83_10155	ENOG4108V2W	Carbonate dehydratase
DO83_10210	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
DO83_10215	ENOG4108YZ4	nudix hydrolase
DO83_10225	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
DO83_10230	ENOG41081BK	membrane protein-like protein
DO83_10240	ENOG4107TB6	phosphoglycerate mutase
DO83_10250	ENOG4105CH2	amidohydrolase
DO83_10255	ENOG4105D98	threonine synthase
DO83_10275	ENOG4105D9P	serine threonine protein kinase
DO83_10285	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
DO83_10290	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
DO83_10295	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
DO83_10305	ENOG4105DB7	PHP domain protein
DO83_10320	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
DO83_10325	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
DO83_10330	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
DO83_10335	ENOG410667J	hydrolase
DO83_10380	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
DO83_10390	ENOG4105CY0	Metallo-Beta-Lactamase
DO83_10395	ENOG4105FE9	pseudouridine synthase
DO83_10400	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
DO83_10405	ENOG4105CVG	Homoserine O-transsuccinylase
DO83_10410	ENOG4108HCJ	Hydrolase
DO83_10415	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
DO83_10430	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
DO83_10435	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DO83_10440	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
DO83_10445	ENOG41082DI	50s ribosomal protein l31
DO83_10450	ENOG4105CBJ	Metal-dependent enzyme
DO83_10455	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
DO83_10460	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
DO83_10470	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
DO83_10475	ENOG4105BZU	Histidine kinase
DO83_10480	ENOG4105WH1	Two component transcriptional regulator luxr family
DO83_10505	ENOG4105F3R	pts system mannose fructose sorbose family iid
DO83_10515	ENOG4105D7K	pfkb domain protein
DO83_10520	ENOG410667J	hydrolase
DO83_10550	ENOG4105I8F	Histidine kinase
DO83_10555	ENOG4105D17	glycoside hydrolase, family 3 domain protein
DO83_10560	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
DO83_10565	ENOG4105C83	adenylosuccinate lyase
DO83_10585	ENOG4105BZU	Histidine kinase
DO83_10600	ENOG4105N5T	Radical SAM Protein
DO83_10610	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
DO83_10650	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
DO83_10660	ENOG4105DY9	regulatoR
DO83_10665	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
DO83_10670	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
DO83_10695	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
DO83_10710	ENOG4105FFI	sigma-e processing peptidase spoiiga
DO83_10715	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DO83_10730	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
DO83_10735	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
DO83_10745	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
DO83_10750	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
DO83_10760	ENOG4105CD3	dihydroorotase
DO83_10775	ENOG4107S17	Phosphate-binding protein
DO83_10780	ENOG4105C8U	phosphate abc transporter
DO83_10785	ENOG4105E2Z	phosphate ABC transporter (Permease
DO83_10790	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
DO83_10800	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DO83_10805	ENOG4105BZU	Histidine kinase
DO83_10815	ENOG4108HW3	(ABC) transporter
DO83_10820	ENOG4105E5Q	amino acid AbC transporter
DO83_10825	ENOG4105CDA	abc transporter atp-binding protein
DO83_10840	ENOG4105DIN	metallophosphoesterase
DO83_10870	ENOG4105CMG	Carbohydrate kinase
DO83_10880	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
DO83_10930	ENOG4105BZU	Histidine kinase
DO83_10935	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
DO83_10940	ENOG4105C5A	transporter
DO83_10945	ENOG4105P4J	Allophanate hydrolase, subunit 1
DO83_10955	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
DO83_10960	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
DO83_10965	ENOG4105E7W	lamb ycsf family protein
DO83_10970	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
DO83_10980	ENOG4108RVA	ribokinase
DO83_10985	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
DO83_11015	ENOG4108X4Q	Hydrolase
DO83_11020	ENOG4105DZ1	carboxypeptidase
DO83_11025	ENOG4105CBD	Diacylglycerol kinase
DO83_11050	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
DO83_11060	ENOG4105M59	Phosphodiesterase, mj0936 family
DO83_11065	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
DO83_11070	ENOG4107ZT5	Thiol disulfide interchange protein
DO83_11105	ENOG4105BZU	Histidine kinase
DO83_11125	ENOG41063TF	transcriptional regulator (AraC
DO83_11130	ENOG4105CT4	transporter
DO83_11135	ENOG4105CNT	hydrolase family 2
DO83_11140	ENOG4105IKJ	beta-galactosidase small subunit
DO83_11155	ENOG4107S21	permease
DO83_11165	ENOG4105D6J	arsenicaL-resistance protein
DO83_11200	ENOG4105CJW	magnesium transporter
DO83_11215	ENOG4105EE0	oxidoreductase
DO83_11225	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
DO83_11230	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
DO83_11235	ENOG4105CM2	brancheD-chain amino acid aminotransferase
DO83_11245	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
DO83_11250	ENOG41090GG	peptidase S8 and S53, subtilisin, kexin, sedolisin
DO83_11260	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
DO83_11270	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
DO83_11275	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
DO83_11285	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DO83_11290	ENOG4105BZU	Histidine kinase
DO83_11300	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
DO83_11305	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
DO83_11315	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
DO83_11340	ENOG4105D7N	magnesium and cobalt transport protein CorA
DO83_11375	ENOG4105VB9	50S ribosomal protein l28
DO83_11390	ENOG4105CB5	ATP-dependent DNA helicase recG
DO83_11395	ENOG41084AG	Acylphosphatase
DO83_11405	ENOG4106H78	methyltransferase
DO83_11410	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
DO83_11425	ENOG4105CDE	UPF0348 protein
DO83_11430	ENOG4108IJ2	phosphate acetyltransferase
DO83_11445	ENOG41082GS	50S ribosomal protein L32
DO83_11450	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
DO83_11455	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
DO83_11465	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
DO83_11470	ENOG4105C7B	Threonine dehydratase
DO83_11480	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
DO83_11490	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
DO83_11495	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
DO83_11500	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
DO83_11510	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
DO83_11515	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
DO83_11525	ENOG4105KG3	cytidine deaminase
DO83_11530	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
DO83_11535	ENOG4105CXI	aluminum resistance protein
DO83_11540	ENOG4105W5Q	DNA repair protein (RadC
DO83_11565	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
DO83_11575	ENOG41083CN	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
DO83_11580	ENOG4105CNI	cell division protein FtsW
DO83_11585	ENOG4108Z5K	methylglyoxal synthase
DO83_11590	ENOG4105DZ1	carboxypeptidase
DO83_11595	ENOG4105N5T	Radical SAM Protein
DO83_11605	ENOG4105DFA	alanine racemase domain protein
DO83_11610	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
DO83_11615	ENOG4105DBK	s4 domain protein
DO83_11620	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
DO83_11625	ENOG4105D49	3-dehydroquinate synthase
DO83_11630	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
DO83_11635	ENOG4105C34	Pseudouridine synthase
DO83_11640	ENOG4105II7	pyrroline-5-carboxylate reductase
DO83_11645	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
DO83_11650	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
DO83_11665	ENOG4108Z03	MAF-like protein
DO83_11670	ENOG4105EPR	degv family
DO83_11685	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
DO83_11700	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
DO83_11710	ENOG4105YHU	PTS system
DO83_11715	ENOG4108IQ3	PTS system
DO83_11720	ENOG4105ETZ	PTS System
DO83_11725	ENOG4105F3R	pts system mannose fructose sorbose family iid
DO83_11730	ENOG4105DXH	Alcohol dehydrogenase zinc-binding domain protein
DO83_11735	ENOG4106KNT	transcriptional regulator
DO83_11740	ENOG4105CHR	reductase
DO83_11750	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
DO83_11755	ENOG4105CID	antiterminator
DO83_11760	ENOG4105KZ7	phosphocarrier protein hpr
DO83_11765	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
DO83_11890	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
DO83_11895	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
DO83_11900	ENOG4105ENA	helicase
DO83_11915	ENOG4107RWR	Sodium hydrogen exchanger
DO83_11930	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
DO83_11940	ENOG4105C37	(CBS) domain
DO83_11945	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
DO83_11950	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
DO83_11955	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
DO83_11965	ENOG4108QBF	Transcriptional regulator
DO83_11970	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
DO83_11980	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
DO83_11985	ENOG4105CX6	glutaminyL-tRNA synthetase
DO83_11995	ENOG4108IQ3	PTS system
DO83_12000	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
DO83_12005	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
DO83_12015	ENOG4105CPQ	Dehydrogenase
DO83_12020	ENOG4107QW4	alcohol dehydrogenase
DO83_12025	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
DO83_12030	ENOG4105BZ8	glutamate synthase
DO83_12040	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
DO83_12060	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
DO83_12065	ENOG4105DJ4	phosphatidylserine decarboxylase
DO83_12070	ENOG4105BZG	amino acid carrier protein
DO83_12075	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DO83_12085	ENOG4105CID	antiterminator
DO83_12090	ENOG4105C5Y	PTS System
DO83_12095	ENOG4105CS2	ec 3.2.1.21
DO83_12100	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
DO83_12110	ENOG4107RZC	phospholipase d
DO83_12130	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
DO83_12140	ENOG4107RZC	phospholipase d
DO83_12145	ENOG4108KP7	hydrolase
DO83_12165	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
DO83_12185	ENOG4108IG5	Transcriptional regulator
DO83_12205	ENOG4108IG5	Transcriptional regulator
DO83_12225	ENOG4105BZU	Histidine kinase
DO83_12235	ENOG4106P55	Transcriptional regulator
DO83_12250	ENOG4105CV8	reductase
DO83_12270	ENOG4105DYB	Isoaspartyl dipeptidase
DO83_12275	ENOG4105DFD	Na H antiporter
DO83_12280	ENOG4105DBI	uridine monophosphokinase
DO83_12305	ENOG4105KJF	protein tyrosine phosphatase
DO83_12315	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
DO83_12320	ENOG4105DM4	PTS System
DO83_12325	ENOG4105CMD	Transcriptional regulator, GntR family
DO83_12330	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
DO83_12345	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
DO83_12350	ENOG4105EQD	regulatoR
DO83_12355	ENOG4105C2F	Histidine kinase
DO83_12360	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
DO83_12365	ENOG4105C2J	ABC transporter
DO83_12370	ENOG4107R9N	ABC transporter
DO83_12375	ENOG41062B0	ABC transporter, permease
DO83_12385	ENOG4105T16	Transcriptional regulator (AraC family)
DO83_12410	ENOG4108RS6	transposase
DO83_12415	ENOG4105CQ4	Transcriptional regulator
DO83_12425	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
DO83_12430	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
DO83_12435	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
DO83_12440	ENOG4105CMR	udp-glucose 4-epimerase
DO83_12445	ENOG4105BZ1	(ABC) transporter
DO83_12450	ENOG4105BZ1	(ABC) transporter
DO83_12460	ENOG4105FGV	Chromate
DO83_12465	ENOG4105C9U	ATP-dependent DNA helicase RecQ
DO83_12475	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
DO83_12485	ENOG4108S0H	Dipicolinic acid synthetase, b subunit
DO83_12490	ENOG4105CAQ	asparagine synthetase
DO83_12505	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
DO83_12520	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
DO83_12535	ENOG4105CHM	Aminotransferase
DO83_12545	ENOG4105DC1	bifunctional purine biosynthesis protein purh
DO83_12555	ENOG4105F1A	Pyruvate formate-lyase
DO83_12560	ENOG4108RS6	transposase
DO83_12590	ENOG4105C3G	gtp-binding protein
DO83_12595	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
DO83_12600	ENOG4108V6E	Cell division protein mraZ
DO83_12605	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
DO83_12615	ENOG4105CJN	penicillin-binding protein
DO83_12620	ENOG4105CJN	penicillin-binding protein
DO83_12625	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
DO83_12630	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
DO83_12635	ENOG4105CNI	cell division protein FtsW
DO83_12645	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
DO83_12650	ENOG4107QW8	radical SAM domain protein
DO83_12655	ENOG4105CI3	gtp-binding protein typa
DO83_12665	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
DO83_12670	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
DO83_12675	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
DO83_12715	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
DO83_12735	ENOG4105CEY	Amp-dependent synthetase and ligase
DO83_12800	ENOG4105VTR	Integrase
DO83_12810	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
DO83_12820	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
DO83_12825	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
DO83_12830	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
DO83_12835	ENOG4105KFW	domain protein
DO83_12840	ENOG4105EEI	dihydropteroate synthase
DO83_12845	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DO83_12850	ENOG4105CQC	Prephenate dehydratase
DO83_12855	ENOG4107T7U	Sulfatase
DO83_12860	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
DO83_12870	ENOG4105KME	endoribonuclease L-psp
DO83_12875	ENOG4107QZB	decarboxylase
DO83_12905	ENOG4105DCG	PHP domain protein
DO83_12915	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
DO83_12920	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
DO83_12925	ENOG4105CFP	Peptidase U32
DO83_12935	ENOG4105CJN	penicillin-binding protein
DO83_12945	ENOG4105DZ1	carboxypeptidase
DO83_12950	ENOG4105CHR	reductase
DO83_12955	ENOG4105EMD	TRANSCRIPTIONal
DO83_12965	ENOG410787A	Pts system, glucitol sorbitol-specific
DO83_12970	ENOG4105DZY	Pts system, glucitol sorbitol-specific
DO83_12975	ENOG4105VI0	Pts system, glucitol sorbitol-specific
DO83_12990	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
DO83_12995	ENOG4105C7K	acetolactate synthase
DO83_13000	ENOG4108ZP8	Acetolactate synthase small subunit
DO83_13005	ENOG4105CHU	acetyl-coa acetyltransferase
DO83_13010	ENOG4105E39	Enoyl-CoA hydratase
DO83_13015	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
DO83_13020	ENOG4105C1G	acyl-Coa dehydrogenase
DO83_13025	ENOG4105BZJ	Electron transfer flavoprotein
DO83_13040	ENOG4105CYC	Transferase
DO83_13055	ENOG4105DZ1	carboxypeptidase
DO83_13060	ENOG41080E8	Transcriptional regulator, Spx MgsR family
DO83_13065	ENOG4105DFM	M18 family aminopeptidase
DO83_13075	ENOG4105S7A	ErfK ybiS ycfS ynhG family protein
DO83_13080	ENOG4105C8T	Leucyl-tRNA synthetase
DO83_13090	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
DO83_13115	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
DO83_13120	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
DO83_13125	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
DO83_13130	ENOG4107QM5	aconitate hydratase
DO83_13135	ENOG4107S6Z	Na H antiporter
DO83_13140	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
DO83_13155	ENOG4105K4H	Nlp p60 protein
DO83_13160	ENOG4105RKW	reductase (By
DO83_13180	ENOG4105K46	50S ribosomal protein l27
DO83_13185	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DO83_13190	ENOG410812S	Rna-binding protein
DO83_13195	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
DO83_13200	ENOG4108WF2	Metal Dependent Phosphohydrolase
DO83_13210	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
DO83_13215	ENOG41067Z0	domain protein
DO83_13220	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
DO83_13225	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
DO83_13245	ENOG4105C01	Dihydroxy-acid dehydratase
DO83_13250	ENOG4105C7K	acetolactate synthase
DO83_13255	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
DO83_13260	ENOG4108JQ1	Dehydrogenase
DO83_13265	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
DO83_13270	ENOG4105D64	Mechanosensitive ion channel
DO83_13280	ENOG4107Z5F	Aminotransferase class IV
DO83_13285	ENOG4105CRQ	synthase (Component I)
DO83_13290	ENOG4105DDQ	anthranilate synthase
DO83_13350	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
DO83_13355	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
DO83_13360	ENOG4107QI6	Cysteine desulfurase
DO83_13375	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
DO83_13380	ENOG4105VBH	UPF0297 protein
DO83_13395	ENOG4105CN5	Metallo-Beta-Lactamase
DO83_13405	ENOG4108VQJ	O-methyltransferase
DO83_13410	ENOG4105CFP	Peptidase U32
DO83_13415	ENOG4105DMD	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DO83_13505	ENOG4105ETX	regulatoR
DO83_13510	ENOG4105BZU	Histidine kinase
DO83_13545	ENOG4105C5Q	Transcriptional regulator
DO83_13555	ENOG4105EMV	Major Facilitator
DO83_13570	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
DO83_13575	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
DO83_13580	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
DO83_13590	ENOG4105C5Q	Transcriptional regulator
DO83_13600	ENOG4107QW4	alcohol dehydrogenase
DO83_13605	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
DO83_13615	ENOG4105CGK	Exodeoxyribonuclease III
DO83_13620	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
DO83_13630	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
DO83_13635	ENOG4108I5D	sulfate abc transporter
DO83_13640	ENOG4105ECW	sulfate abc transporter
DO83_13655	ENOG4105WCA	Ferredoxin
DO83_13660	ENOG4105C11	sulfate adenylyltransferase), subunit 2
DO83_13675	ENOG4105CTS	PTS system mannitol-specific
DO83_13680	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
DO83_13685	ENOG4105C6N	Formate acetyltransferase
DO83_13690	ENOG4105F1A	Pyruvate formate-lyase
DO83_13695	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
DO83_13700	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
DO83_13705	ENOG4106FTQ	Taurine ABC transporter, periplasmic
DO83_13710	ENOG4108IY8	ABC, transporter
DO83_13715	ENOG4105C0A	alcohol dehydrogenase
DO83_13720	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
DO83_13725	ENOG4105F23	Fibronectin-binding protein
DO83_13735	ENOG4108IQ6	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
DO83_13740	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
DO83_13745	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
DO83_13750	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
DO83_13760	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
DO83_13765	ENOG4105VCC	30S ribosomal protein S21
DO83_13780	ENOG4105C9A	Phoh family
DO83_13800	ENOG4105CBX	hi0933 family
DO83_13805	ENOG4105DZ0	fad dependent oxidoreductase
DO83_13810	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
DO83_13820	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
DO83_13825	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
DO83_13830	ENOG4105D6A	Electron transport complex
DO83_13835	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
DO83_13840	ENOG4105DZB	Electron transport complex
DO83_13845	ENOG4105DGN	Electron transport complex
DO83_13850	ENOG4108R3D	Electron transport complex
DO83_13855	ENOG4105WR5	sporulation protein, YlmC YmxH family
DO83_13860	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
DO83_13865	ENOG4105C0P	Mg chelatase subunit ChlI
DO83_13870	ENOG4105C79	DNA protecting protein DprA
DO83_13875	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
DO83_13885	ENOG4105CE9	30S ribosomal protein S2
DO83_13890	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
DO83_13895	ENOG4107QJE	Chromosome Partitioning Protein
DO83_13900	ENOG4105FA0	parb-like partition protein
DO83_14000	ENOG4105KFN	sortase, SrtB family
DO83_14145	ENOG4105VTR	Integrase
DO83_14165	ENOG4105M6F	mutator MutT protein
DO83_14275	ENOG4108WS4	fmn reductase
DO83_14310	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
DO83_14335	ENOG4105C8Y	Acetylornithine aminotransferase
DO83_14345	ENOG4108JB8	alcohol dehydrogenase
DO83_14360	ENOG4105BZJ	Electron transfer flavoprotein
DO83_14365	ENOG4105C10	Electron transfer flavoprotein
DO83_14380	ENOG4105DWF	phosphomethylpyrimidine kinase
DO83_14400	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
DO83_14405	ENOG4105D52	delta-aminolevulinic acid dehydratase
DO83_14410	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
DO83_14415	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
DO83_14420	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
DO83_14435	ENOG4105UQX	Mate efflux family protein
DO83_14440	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
DO83_14455	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
DO83_14460	ENOG4105E0C	molybdate abc transporter
DO83_14480	ENOG4105F4R	Transcriptional regulator mode
DO83_14495	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
DO83_14500	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
DO83_14505	ENOG4105C87	Aminotransferase class I and II
DO83_14520	ENOG4105FDP	GntR family transcriptional regulator
DO83_14525	ENOG4105DVE	abc transporter atp-binding protein
DO83_14540	ENOG4108FUT	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
DO83_14550	ENOG4105DY9	regulatoR
DO83_14555	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
DO83_14600	ENOG4105K4H	Nlp p60 protein
DO83_14630	ENOG4106128	DNA-binding helix-turn-helix protein
DO83_14635	ENOG4106BHR	ftsk SpoIIIE family protein
DO83_14645	ENOG4108RYM	conjugative transposon protein
DO83_14655	ENOG4105DA5	(ABC) transporter
DO83_14680	ENOG4105C26	Dehydrogenase
DO83_14695	ENOG4108RE9	Phosphodiesterase
DO83_14710	ENOG4105DGA	Diaminopimelate dehydrogenase
DO83_14720	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
DO83_14745	ENOG4105C3S	Mate efflux family protein
DO83_14770	ENOG4105CXT	aspartate transcarbamylase
DO83_14780	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
DO83_14790	ENOG4105D4P	Coproporphyrinogen iii oxidase
DO83_14800	ENOG4105CUT	histidyl-tRNA synthetase
DO83_14810	ENOG4105C9M	aspartyl-trna synthetase
DO83_14815	ENOG4105CFH	Aspartokinase
DO83_14845	ENOG4105C9U	ATP-dependent DNA helicase RecQ
DO83_14850	ENOG4105CD2	stage iii sporulation protein aa
DO83_14890	ENOG4105D5G	Transposase
DO83_14925	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
DO83_14930	ENOG4108BN2	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
DO83_14985	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
DO83_15010	ENOG4107AYK	membrAne
DO83_15035	ENOG4107YDN	peptide deformylase
DO83_15095	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
DO83_15115	ENOG4105CGU	Enoyl-CoA hydratase
DO83_15120	ENOG4107QP7	CoA-transferase subunit A
DO83_15125	ENOG4107QNJ	CoA-transferase subunit B
DO83_15135	ENOG4105CIZ	coA-substrate-specific enzyme activase
DO83_15140	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
DO83_15150	ENOG4105D7V	transposase
DO83_15155	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
DO83_15160	ENOG4105F38	ABC transporter, permease
DO83_15165	ENOG4105D38	putrescine abc transporter
DO83_15175	ENOG4105EJ5	oxidoreductase gamma subunit
DO83_15185	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
DO83_15190	ENOG4105DDK	oxidoreductase, beta subunit
DO83_15195	ENOG4107RSM	transcriptional regulator
DO83_15200	ENOG4105DXH	Alcohol dehydrogenase zinc-binding domain protein
DO83_15205	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
DO83_15215	ENOG4105SKE	transcriptional Regulator LysR family
DO83_15220	ENOG4108RCF	TRANSCRIPTIONal
DO83_15245	ENOG4107QHE	Choloylglycine hydrolase
DO83_15250	ENOG4107Y3V	-acetyltransferase
DO83_15255	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
DO83_15265	ENOG4105CE1	Ferrous iron transport protein b
DO83_15275	ENOG4105VPX	protein, conserved in bacteria
DO83_15290	ENOG4105C22	threonyL-tRNA synthetase
DO83_15300	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
DO83_15305	ENOG4107RN3	metallophosphoesterase
DO83_15320	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
DO83_15330	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DO83_15380	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)