locus-tag	class	description
DO83_00060	COG0534	Mate efflux family protein
DO83_00085	COG0196	riboflavin kinase activity
DO83_00090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DO83_00095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DO83_00100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DO83_00105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DO83_00115	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DO83_00120	COG0195	Participates in both transcription termination and antitermination
DO83_00135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DO83_00140	COG0750	zinc metalloprotease
DO83_00150	COG4589	Belongs to the CDS family
DO83_00160	COG0233	cytoplasmic translational termination
DO83_00165	COG0528	UMP kinase activity
DO83_00180	COG1924	4 iron, 4 sulfur cluster binding
DO83_00200	COG1490	D-aminoacyl-tRNA deacylase activity
DO83_00210	COG0440	acetolactate synthase activity
DO83_00215	COG1316	TRANSCRIPTIONal
DO83_00225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DO83_00230	COG0187	DNA topoisomerase II activity
DO83_00255	COG0745	RESPONSE REGULATOR receiver
DO83_00270	COG0419	ATPase involved in DNA repair
DO83_00275	COG0420	3'-5' exonuclease activity
DO83_00280	COG0750	zinc metalloprotease
DO83_00285	COG0497	DNA recombination
DO83_00290	COG1438	arginine binding
DO83_00295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DO83_00300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DO83_00305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DO83_00315	COG1722	exodeoxyribonuclease VII activity
DO83_00320	COG1570	exodeoxyribonuclease VII activity
DO83_00325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DO83_00330	COG1302	Protein conserved in bacteria
DO83_00340	COG4145	pantothenate transmembrane transporter activity
DO83_00420	COG1131	(ABC) transporter
DO83_00435	COG5002	protein histidine kinase activity
DO83_00460	COG0534	Mate efflux family protein
DO83_00475	COG5002	protein histidine kinase activity
DO83_00480	COG0745	RESPONSE REGULATOR receiver
DO83_00485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_00495	COG0372	Belongs to the citrate synthase family
DO83_00500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_00505	COG2357	RelA SpoT domain protein
DO83_00510	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DO83_00530	COG1475	DNA binding
DO83_00540	COG1475	DNA binding
DO83_00550	COG0656	L-ascorbic acid biosynthetic process
DO83_00565	COG0789	Transcriptional regulator
DO83_00605	COG0217	transcriptional regulatory protein
DO83_00615	COG2337	Toxic component of a toxin-antitoxin (TA) module
DO83_00620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DO83_00625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DO83_00625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DO83_00630	COG0736	holo-[acyl-carrier-protein] synthase activity
DO83_00640	COG0488	(ABC) transporter
DO83_00645	COG1215	transferase activity, transferring glycosyl groups
DO83_00655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DO83_00660	COG0481	GTPase activity
DO83_00670	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DO83_00675	COG0268	Binds directly to 16S ribosomal RNA
DO83_00680	COG1466	dna polymerase III delta subunit
DO83_00685	COG0658	competence protein
DO83_00685	COG2333	competence protein COMEC
DO83_00695	COG5002	protein histidine kinase activity
DO83_00700	COG0745	RESPONSE REGULATOR receiver
DO83_00715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DO83_00720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DO83_00725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DO83_00730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DO83_00760	COG0165	Argininosuccinate lyase
DO83_00780	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DO83_00790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DO83_00820	COG0484	heat shock protein binding
DO83_00825	COG0443	Heat shock 70 kDa protein
DO83_00830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DO83_00835	COG1420	regulation of RNA biosynthetic process
DO83_00850	COG1349	DNA-binding transcription factor activity
DO83_00860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DO83_00875	COG0640	Transcriptional regulator
DO83_00880	COG0561	phosphatase activity
DO83_00905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DO83_00920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DO83_00925	COG0237	dephospho-CoA kinase activity
DO83_00930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DO83_00930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DO83_00940	COG1959	2 iron, 2 sulfur cluster binding
DO83_00950	COG0494	nUDIX hydrolase
DO83_00965	COG0628	permease
DO83_00975	COG0493	'glutamate synthase
DO83_00985	COG0534	Mate efflux family protein
DO83_01000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DO83_01005	COG0302	gtp cyclohydrolase
DO83_01010	COG0602	queuosine metabolic process
DO83_01015	COG0720	synthase
DO83_01020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_01020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_01020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_01030	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DO83_01045	COG3177	Filamentation induced by cAMP protein fic
DO83_01060	COG0583	DNA-binding transcription factor activity
DO83_01090	COG3409	Peptidoglycan-binding domain 1 protein
DO83_01090	COG3773	Cell wall hydrolase
DO83_01110	COG1737	Transcriptional regulator
DO83_01115	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DO83_01120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DO83_01130	COG2384	SAM-dependent methyltransferase
DO83_01135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DO83_01140	COG0358	DNA primase activity
DO83_01145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DO83_01150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DO83_01155	COG1968	undecaprenyl-diphosphatase activity
DO83_01165	COG0194	GDP metabolic process
DO83_01170	COG1561	YicC-like family, N-terminal region
DO83_01180	COG0564	pseudouridine synthase activity
DO83_01185	COG4221	oxidoreductase activity
DO83_01190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DO83_01195	COG1187	pseudouridine synthase activity
DO83_01200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DO83_01200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DO83_01205	COG2357	RelA SpoT domain protein
DO83_01210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DO83_01215	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DO83_01235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DO83_01250	COG1160	GTP binding
DO83_01260	COG0792	nuclease activity
DO83_01265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DO83_01270	COG0681	Belongs to the peptidase S26 family
DO83_01285	COG0335	large ribosomal subunit rRNA binding
DO83_01290	COG0561	phosphatase activity
DO83_01295	COG0336	Belongs to the RNA methyltransferase TrmD family
DO83_01300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DO83_01305	COG2195	Cleaves the N-terminal amino acid of tripeptides
DO83_01320	COG1297	OPT oligopeptide transporter protein
DO83_01340	COG0297	glycogen (starch) synthase activity
DO83_01350	COG4824	toxin secretion phage lysis holin
DO83_01365	COG4974	Belongs to the 'phage' integrase family
DO83_01470	COG3728	DNA packaging
DO83_01470	COG5484	DNA packaging
DO83_01640	COG2226	methyltransferase
DO83_01665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DO83_01670	COG0557	exoribonuclease II activity
DO83_01680	COG0148	phosphopyruvate hydratase activity
DO83_01720	COG0534	Mate efflux family protein
DO83_01740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DO83_01755	COG0149	triose-phosphate isomerase activity
DO83_01775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DO83_01785	COG0791	NLP P60 protein
DO83_01785	COG0741	lytic transglycosylase activity
DO83_01845	COG1854	S-ribosylhomocysteine lyase activity
DO83_01855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DO83_01865	COG1837	Belongs to the UPF0109 family
DO83_01870	COG0228	four-way junction DNA binding
DO83_01875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DO83_01885	COG0488	(ABC) transporter
DO83_01890	COG0037	tRNA processing
DO83_01900	COG5002	protein histidine kinase activity
DO83_01905	COG0745	RESPONSE REGULATOR receiver
DO83_01925	COG1058	Belongs to the CinA family
DO83_01925	COG1546	Belongs to the CinA family
DO83_01935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DO83_01960	COG0740	serine-type endopeptidase activity
DO83_01965	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DO83_01975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DO83_01980	COG2081	HI0933 family
DO83_01995	COG0673	inositol 2-dehydrogenase activity
DO83_02000	COG0667	Aldo Keto reductase
DO83_02005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DO83_02010	COG0534	Mate efflux family protein
DO83_02015	COG3883	PFAM NLP P60 protein
DO83_02015	COG0791	NLP P60 protein
DO83_02055	COG0733	neurotransmitter:sodium symporter activity
DO83_02065	COG3655	Transcriptional regulator
DO83_02080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DO83_02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_02090	COG1263	PTS System
DO83_02090	COG2190	(PTS) system
DO83_02095	COG1482	cell wall glycoprotein biosynthetic process
DO83_02105	COG3716	PTS system mannose fructose sorbose family IID component
DO83_02110	COG3715	PTS system
DO83_02120	COG3711	transcriptional antiterminator
DO83_02125	COG1295	ribonuclease BN
DO83_02130	COG0205	6-phosphofructokinase activity
DO83_02135	COG0006	proline dipeptidase activity
DO83_02140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DO83_02145	COG1191	sigma factor activity
DO83_02160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DO83_02175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DO83_02180	COG2226	methyltransferase
DO83_02185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_02190	COG0352	thiamine-phosphate diphosphorylase activity
DO83_02200	COG1074	ATP-dependent DNA helicase activity
DO83_02205	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DO83_02220	COG2011	ABC-type metal ion transport system permease component
DO83_02225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DO83_02230	COG1464	Belongs to the NlpA lipoprotein family
DO83_02335	COG0210	DNA helicase
DO83_02345	COG4496	protein, YerC YecD
DO83_02350	COG1115	amino acid carrier protein
DO83_02355	COG0733	neurotransmitter:sodium symporter activity
DO83_02360	COG0151	Belongs to the GarS family
DO83_02365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DO83_02370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DO83_02380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DO83_02410	COG0167	dihydroorotate dehydrogenase activity
DO83_02415	COG0543	2 iron, 2 sulfur cluster binding
DO83_02420	COG0284	orotidine-5'-phosphate decarboxylase activity
DO83_02440	COG2022	thiamine diphosphate biosynthetic process
DO83_02500	COG0791	NLP P60 protein
DO83_02590	COG0582	viral genome integration into host DNA
DO83_02600	COG1598	PFAM Uncharacterised protein family UPF0150
DO83_02735	COG1346	cytolysis
DO83_02750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DO83_02775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DO83_02785	COG0215	cysteine-tRNA ligase activity
DO83_02790	COG1045	serine acetyltransferase
DO83_02795	COG1268	BioY protein
DO83_02805	COG0110	maltose O-acetyltransferase activity
DO83_02840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DO83_02845	COG1410	methionine synthase
DO83_02845	COG0646	methionine synthase
DO83_02855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DO83_02860	COG1739	Uncharacterized protein family UPF0029
DO83_02880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DO83_02905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DO83_02945	COG0726	polysaccharide deacetylase
DO83_02950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DO83_02955	COG1263	PTS System
DO83_02955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_02960	COG2190	(PTS) system
DO83_02960	COG1263	PTS System
DO83_02960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_02965	COG3711	transcriptional antiterminator
DO83_03015	COG2226	methyltransferase
DO83_03030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DO83_03035	COG0066	3-isopropylmalate dehydratase activity
DO83_03040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DO83_03045	COG0066	3-isopropylmalate dehydratase activity
DO83_03065	COG0569	domain protein
DO83_03070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DO83_03075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DO83_03090	COG3775	system Galactitol-specific IIC component
DO83_03100	COG3711	transcriptional antiterminator
DO83_03105	COG2357	RelA SpoT domain protein
DO83_03110	COG0730	response to heat
DO83_03120	COG3546	catalase activity
DO83_03145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DO83_03150	COG1983	PspC domain protein
DO83_03170	COG1649	PFAM Uncharacterised BCR, COG1649
DO83_03185	COG0287	Prephenate dehydrogenase
DO83_03190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DO83_03200	COG1362	aminopeptidase activity
DO83_03215	COG1349	DNA-binding transcription factor activity
DO83_03225	COG0673	inositol 2-dehydrogenase activity
DO83_03230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DO83_03255	COG3962	Belongs to the TPP enzyme family
DO83_03260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_03265	COG1609	Transcriptional regulator
DO83_03270	COG1349	DNA-binding transcription factor activity
DO83_03280	COG1082	Xylose isomerase domain protein TIM barrel
DO83_03285	COG1082	Xylose isomerase domain protein TIM barrel
DO83_03295	COG1082	Xylose isomerase domain protein TIM barrel
DO83_03300	COG0673	inositol 2-dehydrogenase activity
DO83_03325	COG1082	Xylose isomerase domain protein TIM barrel
DO83_03335	COG0673	inositol 2-dehydrogenase activity
DO83_03345	COG1846	Transcriptional regulator
DO83_03350	COG1960	acyl-CoA dehydrogenase activity
DO83_03355	COG1024	Enoyl-CoA hydratase
DO83_03365	COG2610	gluconate transmembrane transporter activity
DO83_03370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DO83_03375	COG2086	electron transfer activity
DO83_03380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DO83_03385	COG2086	electron transfer activity
DO83_03390	COG1960	acyl-CoA dehydrogenase activity
DO83_03400	COG1621	beta-fructofuranosidase activity
DO83_03405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_03405	COG2190	(PTS) system
DO83_03405	COG1263	PTS System
DO83_03410	COG1609	Transcriptional regulator
DO83_03415	COG4717	serine-type aminopeptidase activity
DO83_03420	COG0420	3'-5' exonuclease activity
DO83_03445	COG1132	(ABC) transporter
DO83_03470	COG1216	Glycosyl transferase, family 2
DO83_03575	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DO83_03640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DO83_03645	COG0436	Aminotransferase
DO83_03675	COG1115	amino acid carrier protein
DO83_03680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DO83_03685	COG1121	(ABC) transporter
DO83_03690	COG0803	Belongs to the bacterial solute-binding protein 9 family
DO83_03710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DO83_03715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DO83_03745	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DO83_03750	COG0561	phosphatase activity
DO83_03755	COG0372	Belongs to the citrate synthase family
DO83_03760	COG1846	Transcriptional regulator
DO83_03765	COG0587	DNA-directed DNA polymerase activity
DO83_03775	COG0445	tRNA wobble uridine modification
DO83_03795	COG1683	Conserved Protein
DO83_03805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DO83_03810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DO83_03815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DO83_03830	COG1115	amino acid carrier protein
DO83_03840	COG1132	(ABC) transporter
DO83_03845	COG1132	(ABC) transporter
DO83_03855	COG0653	protein targeting
DO83_03865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DO83_03880	COG1609	Transcriptional regulator
DO83_03900	COG0523	cobalamin synthesis protein
DO83_03905	COG0371	Dehydrogenase
DO83_03930	COG0561	phosphatase activity
DO83_03940	COG1595	DNA-templated transcription, initiation
DO83_03955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DO83_03965	COG1621	beta-fructofuranosidase activity
DO83_03970	COG1263	PTS System
DO83_03970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_03975	COG1621	beta-fructofuranosidase activity
DO83_03980	COG1609	Transcriptional regulator
DO83_04005	COG0515	serine threonine protein kinase
DO83_04005	COG2815	serine threonine protein kinase
DO83_04010	COG0631	protein serine/threonine phosphatase activity
DO83_04015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DO83_04020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DO83_04020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DO83_04030	COG0242	peptide deformylase activity
DO83_04035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DO83_04040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DO83_04050	COG3958	Transketolase
DO83_04055	COG3959	Transketolase, thiamine diphosphate binding domain
DO83_04065	COG1609	Transcriptional regulator
DO83_04075	COG0538	isocitrate dehydrogenase activity
DO83_04080	COG2188	Transcriptional regulator
DO83_04085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DO83_04090	COG2140	Oxalate decarboxylase
DO83_04115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DO83_04140	COG0463	Glycosyl transferase, family 2
DO83_04140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DO83_04150	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DO83_04170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DO83_04170	COG0463	Glycosyl transferase, family 2
DO83_04175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DO83_04200	COG0463	Glycosyl transferase, family 2
DO83_04220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DO83_04230	COG0562	UDP-galactopyranose mutase
DO83_04255	COG2244	polysaccharide biosynthetic process
DO83_04265	COG0438	transferase activity, transferring glycosyl groups
DO83_04280	COG0110	maltose O-acetyltransferase activity
DO83_04300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DO83_04340	COG2246	polysaccharide biosynthetic process
DO83_04345	COG0463	Glycosyl transferase, family 2
DO83_04355	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DO83_04370	COG1773	rubredoxin
DO83_04370	COG1592	Rubrerythrin
DO83_04380	COG0277	FAD linked oxidase domain protein
DO83_04390	COG2086	electron transfer activity
DO83_04395	COG2186	Transcriptional regulator
DO83_04415	COG2385	sporulation resulting in formation of a cellular spore
DO83_04425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DO83_04455	COG0745	RESPONSE REGULATOR receiver
DO83_04460	COG5002	protein histidine kinase activity
DO83_04465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DO83_04475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DO83_04480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DO83_04495	COG4120	Belongs to the binding-protein-dependent transport system permease family
DO83_04505	COG1640	4-alpha-glucanotransferase
DO83_04510	COG0281	malic enzyme
DO83_04515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DO83_04520	COG3959	Transketolase, thiamine diphosphate binding domain
DO83_04540	COG3711	transcriptional antiterminator
DO83_04565	COG2155	Conserved Protein
DO83_04590	COG1620	l-lactate permease
DO83_04595	COG2195	Cleaves the N-terminal amino acid of tripeptides
DO83_04600	COG1132	(ABC) transporter
DO83_04605	COG4988	ABC transporter
DO83_04610	COG2832	Protein of unknown function (DUF454)
DO83_04615	COG1120	ATPase activity
DO83_04690	COG0191	fructose-bisphosphate aldolase activity
DO83_04710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_04715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_04715	COG3711	transcriptional antiterminator
DO83_04735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DO83_04740	COG0776	regulation of translation
DO83_04745	COG2996	Protein conserved in bacteria
DO83_04760	COG4509	Sortase family
DO83_04770	COG1321	iron dependent repressor
DO83_04775	COG2608	mercury ion transmembrane transporter activity
DO83_04810	COG0443	Heat shock 70 kDa protein
DO83_04830	COG0768	penicillin binding
DO83_04835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DO83_04845	COG0628	permease
DO83_04850	COG0488	(ABC) transporter
DO83_04860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DO83_04885	COG0577	efflux transmembrane transporter activity
DO83_04885	COG1136	(ABC) transporter
DO83_04915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DO83_04920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DO83_04925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DO83_04930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DO83_04935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DO83_04940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DO83_04945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DO83_04965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DO83_04985	COG1131	(ABC) transporter
DO83_05005	COG2801	Transposase and inactivated derivatives
DO83_05025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DO83_05030	COG1609	Transcriptional regulator
DO83_05035	COG1414	Transcriptional regulator
DO83_05040	COG1607	acyl-coa hydrolase
DO83_05050	COG0493	'glutamate synthase
DO83_05090	COG1607	acyl-coa hydrolase
DO83_05095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DO83_05100	COG1960	acyl-CoA dehydrogenase activity
DO83_05110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DO83_05120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DO83_05130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DO83_05135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DO83_05140	COG0356	it plays a direct role in the translocation of protons across the membrane
DO83_05145	COG0698	ribose 5-phosphate isomerase
DO83_05150	COG0009	L-threonylcarbamoyladenylate synthase
DO83_05155	COG0860	N-Acetylmuramoyl-L-alanine amidase
DO83_05170	COG1979	alcohol dehydrogenase
DO83_05180	COG2376	Dihydroxyacetone kinase
DO83_05195	COG2376	Dihydroxyacetone kinase
DO83_05200	COG3775	system Galactitol-specific IIC component
DO83_05225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_05235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DO83_05245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DO83_05245	COG0116	Belongs to the methyltransferase superfamily
DO83_05265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DO83_05285	COG1704	LemA family
DO83_05325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DO83_05330	COG0049	tRNA binding
DO83_05335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DO83_05340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DO83_05355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DO83_05370	COG0733	neurotransmitter:sodium symporter activity
DO83_05385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DO83_05390	COG0222	ribosome binding
DO83_05400	COG0081	regulation of translation
DO83_05410	COG0250	Participates in transcription elongation, termination and antitermination
DO83_05420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DO83_05440	COG5001	Diguanylate cyclase
DO83_05440	COG1716	ATPase activity
DO83_05450	COG0494	nUDIX hydrolase
DO83_05465	COG1132	(ABC) transporter
DO83_05520	COG0784	Response regulator, receiver
DO83_05520	COG2205	protein histidine kinase activity
DO83_05530	COG1115	amino acid carrier protein
DO83_05535	COG0534	Mate efflux family protein
DO83_05545	COG1151	hydroxylamine reductase activity
DO83_05585	COG1846	Transcriptional regulator
DO83_05590	COG1733	regulation of RNA biosynthetic process
DO83_05600	COG0656	L-ascorbic acid biosynthetic process
DO83_05605	COG0110	maltose O-acetyltransferase activity
DO83_05615	COG0789	Transcriptional regulator
DO83_05625	COG3620	sequence-specific DNA binding
DO83_05635	COG3340	Belongs to the peptidase S51 family
DO83_05655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_05655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_05730	COG1136	(ABC) transporter
DO83_05740	COG0745	RESPONSE REGULATOR receiver
DO83_05755	COG1136	(ABC) transporter
DO83_05770	COG2205	protein histidine kinase activity
DO83_05775	COG0745	RESPONSE REGULATOR receiver
DO83_05805	COG1136	(ABC) transporter
DO83_05815	COG0745	RESPONSE REGULATOR receiver
DO83_05845	COG0745	RESPONSE REGULATOR receiver
DO83_05860	COG2205	protein histidine kinase activity
DO83_05885	COG0352	thiamine-phosphate diphosphorylase activity
DO83_05895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DO83_05970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_05970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_06060	COG0488	(ABC) transporter
DO83_06140	COG2003	Belongs to the UPF0758 family
DO83_06205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DO83_06225	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DO83_06225	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DO83_06230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DO83_06250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DO83_06255	COG0569	domain protein
DO83_06260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DO83_06275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DO83_06280	COG1966	Carbon starvation protein
DO83_06285	COG0733	neurotransmitter:sodium symporter activity
DO83_06295	COG0166	Belongs to the GPI family
DO83_06315	COG1481	regulation of sporulation
DO83_06325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DO83_06330	COG1940	carbohydrate kinase activity
DO83_06335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DO83_06340	COG0322	excinuclease ABC activity
DO83_06350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DO83_06350	COG1328	CTP reductase activity
DO83_06365	COG0697	spore germination
DO83_06375	COG1132	(ABC) transporter
DO83_06390	COG0726	polysaccharide deacetylase
DO83_06425	COG1802	Transcriptional regulator
DO83_06430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DO83_06435	COG5632	N-Acetylmuramoyl-L-alanine amidase
DO83_06435	COG3409	Peptidoglycan-binding domain 1 protein
DO83_06440	COG4466	Protein conserved in bacteria
DO83_06450	COG1349	DNA-binding transcription factor activity
DO83_06455	COG0667	Aldo Keto reductase
DO83_06460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_06465	COG0191	fructose-bisphosphate aldolase activity
DO83_06470	COG1063	alcohol dehydrogenase
DO83_06475	COG2271	Major facilitator Superfamily
DO83_06480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DO83_06485	COG1063	alcohol dehydrogenase
DO83_06490	COG1028	Short-chain dehydrogenase reductase Sdr
DO83_06495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DO83_06515	COG3547	Transposase (IS116 IS110 IS902 family)
DO83_06520	COG1132	(ABC) transporter
DO83_06525	COG1132	(ABC) transporter
DO83_06535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DO83_06555	COG2040	homocysteine
DO83_06560	COG1115	amino acid carrier protein
DO83_06580	COG0534	Mate efflux family protein
DO83_06585	COG0673	inositol 2-dehydrogenase activity
DO83_06590	COG3716	PTS system mannose fructose sorbose family IID component
DO83_06595	COG3715	PTS system
DO83_06620	COG0436	Aminotransferase
DO83_06625	COG1522	sequence-specific DNA binding
DO83_06630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DO83_06640	COG2176	DNA-directed DNA polymerase activity
DO83_06645	COG0561	phosphatase activity
DO83_06650	COG0561	phosphatase activity
DO83_06655	COG1309	transcriptional regulator
DO83_06670	COG1136	(ABC) transporter
DO83_06680	COG0745	RESPONSE REGULATOR receiver
DO83_06690	COG3481	metal-dependent phosphohydrolase, HD sub domain
DO83_06695	COG1193	negative regulation of DNA recombination
DO83_06710	COG2199	diguanylate cyclase activity
DO83_06720	COG0552	protein localization to endoplasmic reticulum
DO83_06725	COG1263	PTS System
DO83_06725	COG2190	(PTS) system
DO83_06725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_06730	COG1737	Transcriptional regulator
DO83_06735	COG1737	Transcriptional regulator
DO83_06740	COG1263	PTS System
DO83_06740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_06745	COG1486	melibiose metabolic process
DO83_06750	COG0519	Catalyzes the synthesis of GMP from XMP
DO83_06750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DO83_06755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DO83_06765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DO83_06770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DO83_06780	COG0537	adenosine 5'-monophosphoramidase activity
DO83_06785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DO83_06790	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DO83_06795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DO83_06800	COG3290	protein histidine kinase activity
DO83_06805	COG0457	Tetratricopeptide repeat
DO83_06805	COG0705	Rhomboid family
DO83_06860	COG4086	secreted protein
DO83_06875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DO83_06880	COG0534	Mate efflux family protein
DO83_06900	COG1131	(ABC) transporter
DO83_06905	COG1725	Transcriptional regulator
DO83_06920	COG1610	YqeY-like protein
DO83_06940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DO83_06960	COG0446	pyridine nucleotide-disulphide oxidoreductase
DO83_06965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DO83_06970	COG1609	Transcriptional regulator
DO83_06975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_06975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_06985	COG0246	Mannitol dehydrogenase
DO83_06990	COG3711	transcriptional antiterminator
DO83_07080	COG0726	polysaccharide deacetylase
DO83_07090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DO83_07100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DO83_07115	COG3901	Regulator of nitric oxide reductase transcription
DO83_07115	COG0348	domain, Protein
DO83_07155	COG1105	Belongs to the carbohydrate kinase PfkB family
DO83_07160	COG1349	DNA-binding transcription factor activity
DO83_07170	COG1136	(ABC) transporter
DO83_07175	COG0662	Cupin 2, conserved barrel domain protein
DO83_07180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DO83_07185	COG2205	protein histidine kinase activity
DO83_07190	COG0745	RESPONSE REGULATOR receiver
DO83_07195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DO83_07205	COG1475	DNA binding
DO83_07210	COG1192	Involved in chromosome partitioning
DO83_07215	COG0018	arginyl-trna synthetase
DO83_07225	COG0357	Ribosomal RNA small subunit methyltransferase G
DO83_07230	COG0445	tRNA wobble uridine modification
DO83_07235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DO83_07245	COG0706	membrane insertase activity
DO83_07250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DO83_07255	COG0594	ribonuclease P activity
DO83_07260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DO83_07265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DO83_07270	COG0592	DNA-directed DNA polymerase activity
DO83_07275	COG2501	S4 domain
DO83_07280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DO83_07285	COG0187	DNA topoisomerase II activity
DO83_07290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DO83_07295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DO83_07355	COG1982	Orn Lys Arg decarboxylase major
DO83_07360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DO83_07365	COG0470	DNA polymerase III
DO83_07370	COG1774	PSP1 C-terminal conserved region
DO83_07375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DO83_07380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DO83_07385	COG2002	toxin-antitoxin pair type II binding
DO83_07400	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DO83_07405	COG1846	Transcriptional regulator
DO83_07425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DO83_07430	COG0659	secondary active sulfate transmembrane transporter activity
DO83_07440	COG2715	membrane protein required for spore maturation
DO83_07455	COG0084	hydrolase, TatD family'
DO83_07460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DO83_07470	COG0590	tRNA wobble adenosine to inosine editing
DO83_07480	COG2357	RelA SpoT domain protein
DO83_07495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DO83_07500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DO83_07515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DO83_07520	COG2088	sporulation resulting in formation of a cellular spore
DO83_07530	COG0360	Binds together with S18 to 16S ribosomal RNA
DO83_07540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DO83_07550	COG0359	binds to the 23S rRNA
DO83_07555	COG0305	Participates in initiation and elongation during chromosome replication
DO83_07560	COG1040	competence protein
DO83_07565	COG1194	a g-specific adenine glycosylase
DO83_07570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DO83_07575	COG0765	amino acid transport
DO83_07640	COG1394	ATPase activity, coupled to movement of substances
DO83_07650	COG1737	Transcriptional regulator
DO83_07660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_07660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_07660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_07665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_07665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_07665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_07685	COG0038	chloride channel
DO83_07690	COG0494	nUDIX hydrolase
DO83_07705	COG0786	glutamate:sodium symporter activity
DO83_07715	COG0789	Transcriptional regulator
DO83_07720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DO83_07725	COG0205	6-phosphofructokinase activity
DO83_07735	COG1063	alcohol dehydrogenase
DO83_07745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DO83_07760	COG0515	serine threonine protein kinase
DO83_07785	COG0469	pyruvate kinase activity
DO83_07790	COG0366	Alpha amylase catalytic
DO83_07800	COG2226	methyltransferase
DO83_07835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DO83_07840	COG0534	Mate efflux family protein
DO83_07915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DO83_07920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DO83_07925	COG1687	branched-chain amino acid
DO83_07930	COG0626	cystathionine gamma-synthase activity
DO83_07940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DO83_07945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DO83_07960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_07965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_07965	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DO83_07965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_07970	COG0191	fructose-bisphosphate aldolase activity
DO83_07975	COG0191	fructose-bisphosphate aldolase activity
DO83_07980	COG1940	carbohydrate kinase activity
DO83_07985	COG1737	Transcriptional regulator
DO83_07995	COG1486	melibiose metabolic process
DO83_08000	COG1486	melibiose metabolic process
DO83_08010	COG1263	PTS System
DO83_08010	COG2190	(PTS) system
DO83_08010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_08025	COG0745	RESPONSE REGULATOR receiver
DO83_08030	COG5002	protein histidine kinase activity
DO83_08065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DO83_08090	COG0534	Mate efflux family protein
DO83_08100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DO83_08115	COG0583	DNA-binding transcription factor activity
DO83_08165	COG2080	2 iron, 2 sulfur cluster binding
DO83_08170	COG2080	2 iron, 2 sulfur cluster binding
DO83_08170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DO83_08180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DO83_08185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DO83_08190	COG0193	aminoacyl-tRNA hydrolase activity
DO83_08195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DO83_08210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DO83_08215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_08230	COG3775	system Galactitol-specific IIC component
DO83_08235	COG0371	Dehydrogenase
DO83_08250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DO83_08265	COG2188	Transcriptional regulator
DO83_08285	COG0246	Mannitol dehydrogenase
DO83_08290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_08290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_08290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_08325	COG4989	oxidoreductase activity
DO83_08330	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DO83_08340	COG3547	Transposase (IS116 IS110 IS902 family)
DO83_08345	COG1301	dicarboxylic acid transport
DO83_08360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DO83_08365	COG0569	domain protein
DO83_08370	COG2205	protein histidine kinase activity
DO83_08375	COG0745	RESPONSE REGULATOR receiver
DO83_08380	COG1760	l-serine dehydratase
DO83_08390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DO83_08395	COG0583	DNA-binding transcription factor activity
DO83_08420	COG0484	heat shock protein binding
DO83_08430	COG1454	alcohol dehydrogenase
DO83_08435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_08435	COG3711	transcriptional antiterminator
DO83_08440	COG1735	metal-dependent hydrolase with the TIM-barrel fold
DO83_08455	COG3775	system Galactitol-specific IIC component
DO83_08460	COG4948	Mandelate Racemase Muconate Lactonizing
DO83_08465	COG0800	Aldolase
DO83_08475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DO83_08480	COG0617	tRNA 3'-terminal CCA addition
DO83_08485	COG0584	glycerophosphoryl diester phosphodiesterase
DO83_08495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DO83_08505	COG2205	protein histidine kinase activity
DO83_08510	COG0745	RESPONSE REGULATOR receiver
DO83_08515	COG0004	ammonium transporteR
DO83_08520	COG0004	ammonium transporteR
DO83_08525	COG0347	Belongs to the P(II) protein family
DO83_08545	COG1072	(Pantothenic acid kinase))
DO83_08570	COG1760	l-serine dehydratase
DO83_08575	COG1760	l-serine dehydratase
DO83_08580	COG3142	Participates in the control of copper homeostasis
DO83_08585	COG0385	Bile acid
DO83_08600	COG4485	Bacterial membrane protein, YfhO
DO83_08605	COG1511	domain protein
DO83_08630	COG3279	Response regulator of the LytR AlgR family
DO83_08655	COG0561	phosphatase activity
DO83_08660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DO83_08665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DO83_08675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DO83_08685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_08690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DO83_08690	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DO83_08695	COG0191	fructose-bisphosphate aldolase activity
DO83_08715	COG3715	PTS system
DO83_08720	COG3716	PTS system mannose fructose sorbose family IID component
DO83_08725	COG0246	Mannitol dehydrogenase
DO83_08730	COG0667	Aldo Keto reductase
DO83_08735	COG2801	Transposase and inactivated derivatives
DO83_08760	COG1725	Transcriptional regulator
DO83_08765	COG1131	(ABC) transporter
DO83_08785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DO83_08810	COG1070	Carbohydrate kinase
DO83_08820	COG1773	rubredoxin
DO83_08830	COG1592	Rubrerythrin
DO83_08840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DO83_08850	COG0157	Belongs to the NadC ModD family
DO83_08905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DO83_08910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DO83_08915	COG1028	Short-chain dehydrogenase reductase Sdr
DO83_08920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DO83_08925	COG0511	ligase activity, forming carbon-carbon bonds
DO83_08930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DO83_08935	COG0439	Biotin carboxylase
DO83_08945	COG0825	malonyl-CoA metabolic process
DO83_08955	COG0051	transcription antitermination factor activity, RNA binding
DO83_08960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DO83_08975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DO83_08985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DO83_08995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DO83_09000	COG0255	Belongs to the universal ribosomal protein uL29 family
DO83_09005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DO83_09010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DO83_09015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DO83_09025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DO83_09030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DO83_09035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DO83_09040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DO83_09045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DO83_09050	COG1841	ribosomal large subunit assembly
DO83_09060	COG0201	protein transport
DO83_09075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DO83_09080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DO83_09090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DO83_09095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DO83_09105	COG0203	ribosomal protein L17
DO83_09110	COG1122	ATPase activity
DO83_09115	COG1122	ATPase activity
DO83_09120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DO83_09125	COG0101	tRNA pseudouridine synthase activity
DO83_09135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DO83_09150	COG0148	phosphopyruvate hydratase activity
DO83_09165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DO83_09175	COG0426	domain, Protein
DO83_09185	COG0731	radical SAM domain protein
DO83_09205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DO83_09210	COG0492	ferredoxin-NADP+ reductase activity
DO83_09215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DO83_09220	COG0653	protein targeting
DO83_09225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DO83_09230	COG4492	Belongs to the UPF0735 family
DO83_09235	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DO83_09250	COG2183	response to ionizing radiation
DO83_09255	COG0300	oxidoreductase activity
DO83_09265	COG3835	regulator
DO83_09270	COG2884	Cell division ATP-binding protein ftsE
DO83_09275	COG2177	Part of the ABC transporter FtsEX involved in
DO83_09285	COG0793	Belongs to the peptidase S41A family
DO83_09290	COG1104	cysteine desulfurase activity
DO83_09370	COG0791	NLP P60 protein
DO83_09370	COG0741	lytic transglycosylase activity
DO83_09415	COG2946	Replication initiation factor
DO83_09420	COG1674	ftsk spoiiie
DO83_09470	COG1349	DNA-binding transcription factor activity
DO83_09480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DO83_09485	COG2002	toxin-antitoxin pair type II binding
DO83_09495	COG0802	atpase or kinase
DO83_09500	COG1214	PFAM Peptidase M22, glycoprotease
DO83_09505	COG0456	acetyltransferase
DO83_09510	COG1234	tRNA 3'-trailer cleavage
DO83_09520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DO83_09615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_09615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_09615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_09620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_09625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_09625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_09625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_09635	COG0546	phosphoglycolate phosphatase activity
DO83_09645	COG0698	ribose 5-phosphate isomerase
DO83_09655	COG2376	Dihydroxyacetone kinase
DO83_09670	COG1131	(ABC) transporter
DO83_09705	COG1063	alcohol dehydrogenase
DO83_09710	COG2217	Heavy metal translocating P-type atpase
DO83_09715	COG0640	Transcriptional regulator
DO83_09720	COG0460	homoserine dehydrogenase
DO83_09725	COG1309	transcriptional regulator
DO83_09760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DO83_09760	COG0512	Glutamine amidotransferase of anthranilate synthase
DO83_09775	COG0133	tryptophan synthase activity
DO83_09780	COG0159	tryptophan synthase activity
DO83_09785	COG0436	Aminotransferase
DO83_09790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DO83_09800	COG0628	permease
DO83_09805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DO83_09850	COG5632	N-Acetylmuramoyl-L-alanine amidase
DO83_09850	COG3409	Peptidoglycan-binding domain 1 protein
DO83_09855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DO83_09865	COG2176	DNA-directed DNA polymerase activity
DO83_10010	COG0740	serine-type endopeptidase activity
DO83_10070	COG0791	NLP P60 protein
DO83_10070	COG1388	LysM domain
DO83_10085	COG3299	homolog of phage Mu protein gp47
DO83_10150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DO83_10155	COG0288	reversible hydration of carbon dioxide
DO83_10210	COG1418	mRNA catabolic process
DO83_10215	COG0494	nUDIX hydrolase
DO83_10225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DO83_10230	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DO83_10240	COG0406	alpha-ribazole phosphatase activity
DO83_10250	COG1473	amidohydrolase
DO83_10285	COG0539	negative regulation of cytoplasmic translation
DO83_10290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DO83_10295	COG0343	queuine tRNA-ribosyltransferase activity
DO83_10305	COG0613	PHP domain protein
DO83_10320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DO83_10325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DO83_10325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DO83_10330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DO83_10330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DO83_10335	COG0561	phosphatase activity
DO83_10380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DO83_10390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DO83_10395	COG1187	pseudouridine synthase activity
DO83_10405	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DO83_10410	COG0561	phosphatase activity
DO83_10415	COG0285	dihydrofolate synthase activity
DO83_10430	COG2172	sigma factor antagonist activity
DO83_10440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DO83_10445	COG0254	rRNA binding
DO83_10450	COG3872	metal-dependent enzyme
DO83_10455	COG2890	protein-(glutamine-N5) methyltransferase activity
DO83_10460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DO83_10470	COG1879	ABC-type sugar transport system periplasmic component
DO83_10475	COG4585	Histidine kinase
DO83_10480	COG2197	response regulator
DO83_10505	COG3716	PTS system mannose fructose sorbose family IID component
DO83_10515	COG3583	domain protein
DO83_10515	COG5492	domain, Protein
DO83_10515	COG1621	beta-fructofuranosidase activity
DO83_10520	COG0561	phosphatase activity
DO83_10550	COG2205	protein histidine kinase activity
DO83_10555	COG1472	Belongs to the glycosyl hydrolase 3 family
DO83_10560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DO83_10565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DO83_10585	COG3706	GGDEF domain
DO83_10600	COG1242	4 iron, 4 sulfur cluster binding
DO83_10610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DO83_10650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DO83_10660	COG3279	Response regulator of the LytR AlgR family
DO83_10665	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DO83_10670	COG0402	S-adenosylhomocysteine deaminase activity
DO83_10695	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DO83_10715	COG1191	sigma factor activity
DO83_10730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DO83_10745	COG0423	glycine-tRNA ligase activity
DO83_10750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DO83_10775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DO83_10780	COG0573	inorganic phosphate transmembrane transporter activity
DO83_10785	COG0581	inorganic phosphate transmembrane transporter activity
DO83_10790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DO83_10795	COG0704	Plays a role in the regulation of phosphate uptake
DO83_10800	COG0745	RESPONSE REGULATOR receiver
DO83_10805	COG5002	protein histidine kinase activity
DO83_10810	COG4193	domain, Protein
DO83_10815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DO83_10820	COG0765	amino acid transport
DO83_10830	COG0372	Belongs to the citrate synthase family
DO83_10840	COG1408	metallophosphoesterase
DO83_10870	COG1070	Carbohydrate kinase
DO83_10880	COG3037	sugar-specific permease SgaT UlaA
DO83_10895	COG0561	phosphatase activity
DO83_10940	COG1914	H( )-stimulated, divalent metal cation uptake system
DO83_10945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DO83_10950	COG1984	allophanate hydrolase subunit 2
DO83_10955	COG0511	ligase activity, forming carbon-carbon bonds
DO83_10960	COG0439	Biotin carboxylase
DO83_10965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DO83_10970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DO83_10980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_10995	COG0656	L-ascorbic acid biosynthetic process
DO83_11015	COG0561	phosphatase activity
DO83_11020	COG1686	Belongs to the peptidase S11 family
DO83_11025	COG1597	lipid kinase activity
DO83_11050	COG0116	Belongs to the methyltransferase superfamily
DO83_11060	COG0622	Phosphoesterase
DO83_11065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DO83_11070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DO83_11080	COG0348	domain, Protein
DO83_11080	COG3901	Regulator of nitric oxide reductase transcription
DO83_11090	COG1136	(ABC) transporter
DO83_11105	COG5002	protein histidine kinase activity
DO83_11130	COG2211	Major facilitator Superfamily
DO83_11135	COG3250	beta-galactosidase activity
DO83_11150	COG0640	Transcriptional regulator
DO83_11155	COG0701	Predicted permease
DO83_11165	COG0798	PFAM Bile acid sodium symporter
DO83_11200	COG2239	Acts as a magnesium transporter
DO83_11215	COG0673	inositol 2-dehydrogenase activity
DO83_11225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DO83_11230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DO83_11235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DO83_11245	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DO83_11250	COG1404	Belongs to the peptidase S8 family
DO83_11270	COG0822	iron-sulfur transferase activity
DO83_11275	COG0482	sulfurtransferase activity
DO83_11285	COG0745	RESPONSE REGULATOR receiver
DO83_11290	COG5002	protein histidine kinase activity
DO83_11300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DO83_11305	COG0107	imidazoleglycerol-phosphate synthase activity
DO83_11315	COG1598	PFAM Uncharacterised protein family UPF0150
DO83_11340	COG0598	Magnesium transport protein CorA
DO83_11375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DO83_11390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DO83_11395	COG1254	Belongs to the acylphosphatase family
DO83_11405	COG0742	ribosomal rna small subunit methyltransferase
DO83_11410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DO83_11425	COG1323	Belongs to the UPF0348 family
DO83_11445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DO83_11450	COG0416	fatty acid biosynthetic process
DO83_11455	COG0571	ribonuclease III activity
DO83_11465	COG0552	protein localization to endoplasmic reticulum
DO83_11470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DO83_11485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DO83_11490	COG0297	glycogen (starch) synthase activity
DO83_11500	COG0366	Alpha amylase catalytic
DO83_11500	COG3103	Sh3 type 3 domain protein
DO83_11505	COG1283	sodium-dependent phosphate transmembrane transporter activity
DO83_11510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DO83_11515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DO83_11525	COG0295	cytidine deaminase activity
DO83_11530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DO83_11535	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DO83_11540	COG2003	Belongs to the UPF0758 family
DO83_11545	COG1077	Cell shape determining protein MreB Mrl
DO83_11565	COG0850	regulation of cytokinetic process
DO83_11570	COG2894	cell division
DO83_11575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DO83_11580	COG0772	Belongs to the SEDS family
DO83_11585	COG1803	Methylglyoxal synthase
DO83_11590	COG1686	Belongs to the peptidase S11 family
DO83_11595	COG1242	4 iron, 4 sulfur cluster binding
DO83_11605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DO83_11615	COG2302	S4 RNA-binding domain
DO83_11620	COG3599	regulation of cell shape
DO83_11625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DO83_11635	COG0564	pseudouridine synthase activity
DO83_11640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DO83_11650	COG1185	polyribonucleotide nucleotidyltransferase activity
DO83_11665	COG0424	maF-like protein
DO83_11670	COG1307	EDD domain protein, DegV family
DO83_11685	COG1404	Belongs to the peptidase S8 family
DO83_11690	COG0058	SHG alpha-glucan phosphorylase activity
DO83_11700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DO83_11710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_11715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_11725	COG3716	PTS system mannose fructose sorbose family IID component
DO83_11735	COG1737	Transcriptional regulator
DO83_11750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DO83_11755	COG3711	transcriptional antiterminator
DO83_11760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_11890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DO83_11895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DO83_11900	COG0210	DNA helicase
DO83_11915	COG0475	glutathione-regulated potassium exporter activity
DO83_11930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DO83_11940	COG1253	flavin adenine dinucleotide binding
DO83_11945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DO83_11950	COG1971	Probably functions as a manganese efflux pump
DO83_11955	COG1328	CTP reductase activity
DO83_11955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DO83_11965	COG2186	Transcriptional regulator
DO83_11970	COG0542	response to heat
DO83_11980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DO83_11985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DO83_11995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_12000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DO83_12005	COG0459	protein refolding
DO83_12015	COG1063	alcohol dehydrogenase
DO83_12020	COG1979	alcohol dehydrogenase
DO83_12030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DO83_12030	COG0493	'glutamate synthase
DO83_12040	COG0516	GMP reductase activity
DO83_12040	COG0517	IMP dehydrogenase activity
DO83_12045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DO83_12060	COG1183	phosphatidylcholine synthase activity
DO83_12065	COG0688	phosphatidylethanolamine metabolic process
DO83_12070	COG1115	amino acid carrier protein
DO83_12075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DO83_12085	COG3711	transcriptional antiterminator
DO83_12090	COG1263	PTS System
DO83_12090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_12090	COG2190	(PTS) system
DO83_12095	COG2723	6-phospho-beta-galactosidase activity
DO83_12100	COG0574	Belongs to the PEP-utilizing enzyme family
DO83_12100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DO83_12105	COG1011	Hydrolase
DO83_12110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_12140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_12145	COG0561	phosphatase activity
DO83_12160	COG0784	Response regulator, receiver
DO83_12160	COG2205	protein histidine kinase activity
DO83_12185	COG1309	transcriptional regulator
DO83_12235	COG0583	DNA-binding transcription factor activity
DO83_12250	COG0656	L-ascorbic acid biosynthetic process
DO83_12270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DO83_12275	COG1757	Na H antiporter
DO83_12280	COG0572	uridine kinase
DO83_12305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DO83_12315	COG0632	four-way junction helicase activity
DO83_12320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_12320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_12320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_12325	COG1609	Transcriptional regulator
DO83_12330	COG2160	L-arabinose isomerase activity
DO83_12350	COG2207	Transcriptional regulator
DO83_12350	COG4753	response regulator
DO83_12355	COG2972	Histidine kinase
DO83_12360	COG1879	ABC-type sugar transport system periplasmic component
DO83_12370	COG1172	Belongs to the binding-protein-dependent transport system permease family
DO83_12375	COG1172	Belongs to the binding-protein-dependent transport system permease family
DO83_12385	COG2207	Transcriptional regulator
DO83_12385	COG1609	Transcriptional regulator
DO83_12390	COG2211	Major facilitator Superfamily
DO83_12410	COG1943	Transposase
DO83_12415	COG1609	Transcriptional regulator
DO83_12420	COG2211	Major facilitator Superfamily
DO83_12425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DO83_12435	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DO83_12440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DO83_12445	COG1132	(ABC) transporter
DO83_12450	COG1132	(ABC) transporter
DO83_12460	COG2059	Chromate
DO83_12465	COG0514	ATP-dependent DNA helicase (RecQ)
DO83_12475	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DO83_12485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DO83_12490	COG0367	asparagine synthase
DO83_12505	COG0326	Molecular chaperone. Has ATPase activity
DO83_12510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DO83_12520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DO83_12535	COG0436	Aminotransferase
DO83_12545	COG0138	bifunctional purine biosynthesis protein purh
DO83_12555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DO83_12560	COG1943	Transposase
DO83_12590	COG0012	GTP binding
DO83_12595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DO83_12600	COG2001	Belongs to the MraZ family
DO83_12605	COG0275	rRNA processing
DO83_12615	COG0768	penicillin binding
DO83_12620	COG0768	penicillin binding
DO83_12630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DO83_12635	COG0772	Belongs to the SEDS family
DO83_12645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DO83_12650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DO83_12665	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DO83_12670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DO83_12675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DO83_12715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DO83_12735	COG0318	PFAM AMP-dependent synthetase and ligase
DO83_12800	COG0582	viral genome integration into host DNA
DO83_12810	COG0544	peptidyl-prolyl cis-trans isomerase activity
DO83_12820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DO83_12825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DO83_12830	COG0285	dihydrofolate synthase activity
DO83_12835	COG1418	mRNA catabolic process
DO83_12840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DO83_12845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DO83_12845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DO83_12850	COG1605	Chorismate mutase
DO83_12850	COG0077	Prephenate dehydratase
DO83_12855	COG1368	sulfuric ester hydrolase activity
DO83_12865	COG0681	Belongs to the peptidase S26 family
DO83_12875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DO83_12905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DO83_12915	COG0632	four-way junction helicase activity
DO83_12920	COG2255	four-way junction helicase activity
DO83_12935	COG0768	penicillin binding
DO83_12945	COG1686	Belongs to the peptidase S11 family
DO83_12955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_12955	COG3711	transcriptional antiterminator
DO83_12965	COG3730	PTS system glucitol sorbitol-specific
DO83_12970	COG3732	PTS system glucitol sorbitol-specific
DO83_12990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DO83_12995	COG0028	Belongs to the TPP enzyme family
DO83_13000	COG0440	acetolactate synthase activity
DO83_13005	COG0183	Belongs to the thiolase family
DO83_13010	COG1024	Enoyl-CoA hydratase
DO83_13015	COG1250	3-hydroxyacyl-CoA dehydrogenase
DO83_13020	COG1960	acyl-CoA dehydrogenase activity
DO83_13025	COG2086	electron transfer activity
DO83_13040	COG0427	acetyl-CoA hydrolase
DO83_13055	COG1686	Belongs to the peptidase S11 family
DO83_13060	COG1393	Belongs to the ArsC family
DO83_13065	COG1362	aminopeptidase activity
DO83_13075	COG1376	ErfK ybiS ycfS ynhG family protein
DO83_13090	COG0039	L-malate dehydrogenase activity
DO83_13115	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DO83_13120	COG0352	thiamine-phosphate diphosphorylase activity
DO83_13125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DO83_13130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DO83_13135	COG1757	Na H antiporter
DO83_13140	COG0714	Associated with various cellular activities
DO83_13155	COG0791	NLP P60 protein
DO83_13160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DO83_13165	COG1530	ribonuclease E activity
DO83_13180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DO83_13185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DO83_13190	COG1534	Rna-binding protein
DO83_13195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DO83_13200	COG1713	HD superfamily hydrolase involved in NAD metabolism
DO83_13205	COG0799	negative regulation of ribosome biogenesis
DO83_13210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DO83_13215	COG1388	LysM domain
DO83_13220	COG0860	N-Acetylmuramoyl-L-alanine amidase
DO83_13225	COG0860	N-Acetylmuramoyl-L-alanine amidase
DO83_13245	COG0129	dihydroxy-acid dehydratase activity
DO83_13250	COG0028	Belongs to the TPP enzyme family
DO83_13255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DO83_13260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DO83_13270	COG0668	transmembrane transport
DO83_13280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DO83_13350	COG2264	protein methyltransferase activity
DO83_13355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DO83_13360	COG1104	cysteine desulfurase activity
DO83_13375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DO83_13380	COG4472	Bacterial protein of unknown function (DUF965)
DO83_13395	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DO83_13415	COG1191	sigma factor activity
DO83_13505	COG0745	RESPONSE REGULATOR receiver
DO83_13510	COG5002	protein histidine kinase activity
DO83_13525	COG0583	DNA-binding transcription factor activity
DO83_13545	COG0583	DNA-binding transcription factor activity
DO83_13555	COG2271	Major facilitator Superfamily
DO83_13575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DO83_13580	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DO83_13590	COG0583	DNA-binding transcription factor activity
DO83_13600	COG1979	alcohol dehydrogenase
DO83_13605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DO83_13615	COG0708	Exodeoxyribonuclease III
DO83_13620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DO83_13630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DO83_13635	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DO83_13640	COG4208	sulfate ABC transporter
DO83_13645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DO83_13655	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
DO83_13660	COG0175	sulfate reduction
DO83_13675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_13675	COG2213	PTS system mannitol-specific
DO83_13680	COG0246	Mannitol dehydrogenase
DO83_13685	COG1882	Formate acetyltransferase
DO83_13695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DO83_13700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DO83_13705	COG4521	taurine ABC transporter
DO83_13710	COG1116	anion transmembrane transporter activity
DO83_13715	COG1454	alcohol dehydrogenase
DO83_13720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DO83_13720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DO83_13740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DO83_13745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DO83_13750	COG0131	Imidazoleglycerol-phosphate dehydratase
DO83_13760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DO83_13765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DO83_13780	COG1702	phosphate starvation-inducible protein PhoH
DO83_13790	COG2244	polysaccharide biosynthetic process
DO83_13800	COG2081	HI0933 family
DO83_13805	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DO83_13810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DO83_13820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DO83_13825	COG4656	Part of a membrane complex involved in electron transport
DO83_13830	COG4658	electron transport chain
DO83_13835	COG4659	FMN binding
DO83_13840	COG4660	Part of a membrane complex involved in electron transport
DO83_13845	COG4657	Part of a membrane complex involved in electron transport
DO83_13850	COG2878	Part of a membrane complex involved in electron transport
DO83_13855	COG1873	PFAM PRC-barrel domain
DO83_13860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DO83_13865	COG0606	chelatase, subunit chli
DO83_13870	COG0758	DNA mediated transformation
DO83_13875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DO83_13885	COG0052	Belongs to the universal ribosomal protein uS2 family
DO83_13895	COG1192	Involved in chromosome partitioning
DO83_13900	COG1475	DNA binding
DO83_14000	COG4509	Sortase family
DO83_14145	COG0582	viral genome integration into host DNA
DO83_14165	COG0494	nUDIX hydrolase
DO83_14275	COG0655	NAD(P)H dehydrogenase (quinone) activity
DO83_14310	COG4115	mRNA cleavage
DO83_14335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DO83_14345	COG1454	alcohol dehydrogenase
DO83_14360	COG2086	electron transfer activity
DO83_14365	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DO83_14380	COG0352	thiamine-phosphate diphosphorylase activity
DO83_14380	COG0351	phosphomethylpyrimidine kinase
DO83_14400	COG1648	precorrin-2 dehydrogenase activity
DO83_14400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DO83_14405	COG0113	porphobilinogen synthase activity
DO83_14410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DO83_14415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DO83_14420	COG0181	hydroxymethylbilane synthase activity
DO83_14425	COG0671	phosphoesterase, PA-phosphatase related
DO83_14435	COG0534	Mate efflux family protein
DO83_14440	COG0709	Synthesizes selenophosphate from selenide and ATP
DO83_14455	COG0521	Mo-molybdopterin cofactor biosynthetic process
DO83_14460	COG4149	molybdate abc transporter
DO83_14480	COG3585	molybdate ion transport
DO83_14480	COG2005	Transcriptional regulator
DO83_14495	COG3608	succinylglutamate desuccinylase aspartoacylase
DO83_14495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DO83_14500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DO83_14500	COG3608	succinylglutamate desuccinylase aspartoacylase
DO83_14505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DO83_14525	COG1131	(ABC) transporter
DO83_14540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DO83_14550	COG3279	Response regulator of the LytR AlgR family
DO83_14555	COG3290	protein histidine kinase activity
DO83_14600	COG0791	NLP P60 protein
DO83_14600	COG0741	lytic transglycosylase activity
DO83_14630	COG2946	Replication initiation factor
DO83_14635	COG1674	ftsk spoiiie
DO83_14655	COG1131	(ABC) transporter
DO83_14670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DO83_14680	COG1012	belongs to the aldehyde dehydrogenase family
DO83_14695	COG0622	Phosphoesterase
DO83_14715	COG2738	Putative neutral zinc metallopeptidase
DO83_14720	COG0328	RNA-DNA hybrid ribonuclease activity
DO83_14740	COG0824	Thioesterase
DO83_14770	COG0540	Belongs to the ATCase OTCase family
DO83_14780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DO83_14790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DO83_14800	COG0124	histidyl-tRNA synthetase
DO83_14810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DO83_14815	COG0527	aspartate kinase activity
DO83_14845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DO83_14845	COG0551	DNA topoisomerase type I activity
DO83_14850	COG3854	ATPases associated with a variety of cellular activities
DO83_14890	COG3328	transposase activity
DO83_14925	COG1518	maintenance of DNA repeat elements
DO83_14930	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DO83_14985	COG1401	restriction endodeoxyribonuclease activity
DO83_15010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DO83_15035	COG0242	peptide deformylase activity
DO83_15095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DO83_15115	COG1024	Enoyl-CoA hydratase
DO83_15120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DO83_15125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DO83_15135	COG1924	4 iron, 4 sulfur cluster binding
DO83_15140	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DO83_15155	COG3842	ATPase activity
DO83_15160	COG1176	ABC-type spermidine putrescine transport system, permease component I
DO83_15165	COG1177	transmembrane transport
DO83_15175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DO83_15185	COG0674	pyruvate-flavodoxin oxidoreductase activity
DO83_15190	COG1013	pyruvate-flavodoxin oxidoreductase activity
DO83_15195	COG0583	DNA-binding transcription factor activity
DO83_15200	COG1063	alcohol dehydrogenase
DO83_15205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DO83_15215	COG0583	DNA-binding transcription factor activity
DO83_15220	COG1316	TRANSCRIPTIONal
DO83_15245	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DO83_15250	COG1247	-acetyltransferase
DO83_15255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DO83_15265	COG1918	ferrous iron import across plasma membrane
DO83_15265	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DO83_15275	COG1937	Protein conserved in bacteria
DO83_15300	COG0519	Catalyzes the synthesis of GMP from XMP
DO83_15305	COG1408	metallophosphoesterase
DO83_15330	COG4974	Belongs to the 'phage' integrase family
DO83_15380	COG0024	Methionine aminopeptidase