locus-tag	class	description
CPRO_00020	COG0592	DNA-directed DNA polymerase activity
CPRO_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CPRO_00050	COG0187	DNA topoisomerase II activity
CPRO_00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPRO_00120	COG1597	lipid kinase activity
CPRO_00130	COG1192	Involved in chromosome partitioning
CPRO_00140	COG1475	DNA binding
CPRO_00160	COG0561	phosphatase activity
CPRO_00170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CPRO_00190	COG2076	Multidrug Resistance protein
CPRO_00210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPRO_00230	COG1609	Transcriptional regulator
CPRO_00250	COG2033	superoxide reductase activity
CPRO_00260	COG0426	domain, Protein
CPRO_00270	COG1592	Rubrerythrin
CPRO_00280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPRO_00290	COG0505	Belongs to the CarA family
CPRO_00300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CPRO_00310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CPRO_00320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CPRO_00330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CPRO_00340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CPRO_00350	COG4989	oxidoreductase activity
CPRO_00390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPRO_00390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPRO_00400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPRO_00410	COG0733	neurotransmitter:sodium symporter activity
CPRO_00430	COG1115	amino acid carrier protein
CPRO_00470	COG0516	GMP reductase activity
CPRO_00470	COG0517	IMP dehydrogenase activity
CPRO_00510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CPRO_00520	COG2183	response to ionizing radiation
CPRO_00580	COG0629	single-stranded DNA binding
CPRO_00590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CPRO_00600	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CPRO_00610	COG1181	Belongs to the D-alanine--D-alanine ligase family
CPRO_00620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CPRO_00630	COG3437	response regulator, receiver
CPRO_00650	COG3118	belongs to the thioredoxin family
CPRO_00670	COG1620	l-lactate permease
CPRO_00680	COG0039	L-malate dehydrogenase activity
CPRO_00700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPRO_00710	COG2002	toxin-antitoxin pair type II binding
CPRO_00730	COG0700	Nucleoside recognition
CPRO_00750	COG0590	tRNA wobble adenosine to inosine editing
CPRO_00770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CPRO_00820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CPRO_00830	COG1116	anion transmembrane transporter activity
CPRO_00840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPRO_00850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CPRO_00910	COG0697	spore germination
CPRO_00960	COG1803	Methylglyoxal synthase
CPRO_00970	COG0772	Belongs to the SEDS family
CPRO_00990	COG2894	cell division
CPRO_01010	COG0768	penicillin binding
CPRO_01030	COG1792	Involved in formation and maintenance of cell shape
CPRO_01040	COG1077	Cell shape determining protein MreB Mrl
CPRO_01060	COG1245	4Fe-4S binding domain
CPRO_01060	COG2878	Part of a membrane complex involved in electron transport
CPRO_01070	COG4657	Part of a membrane complex involved in electron transport
CPRO_01080	COG4660	Part of a membrane complex involved in electron transport
CPRO_01100	COG4658	electron transport chain
CPRO_01110	COG4656	Part of a membrane complex involved in electron transport
CPRO_01120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CPRO_01150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CPRO_01170	COG1114	Component of the transport system for branched-chain amino acids
CPRO_01200	COG1404	Belongs to the peptidase S8 family
CPRO_01230	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CPRO_01260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPRO_01280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CPRO_01340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CPRO_01350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CPRO_01360	COG0358	DNA primase activity
CPRO_01370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPRO_01380	COG2384	SAM-dependent methyltransferase
CPRO_01390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CPRO_01400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPRO_01430	COG0582	viral genome integration into host DNA
CPRO_01560	COG4974	Belongs to the 'phage' integrase family
CPRO_01590	COG0288	reversible hydration of carbon dioxide
CPRO_01630	COG0628	permease
CPRO_01640	COG3275	phosphorelay sensor kinase activity
CPRO_01650	COG3279	Response regulator of the LytR AlgR family
CPRO_01660	COG1966	Carbon starvation protein
CPRO_01690	COG0813	purine-nucleoside phosphorylase activity
CPRO_01700	COG1757	Na H antiporter
CPRO_01720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CPRO_01730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPRO_01740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CPRO_01760	COG3842	ATPase activity
CPRO_01780	COG0681	Belongs to the peptidase S26 family
CPRO_01830	COG0488	(ABC) transporter
CPRO_01840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CPRO_01860	COG0534	Mate efflux family protein
CPRO_01870	COG0789	Transcriptional regulator
CPRO_01890	COG0411	ABC transporter
CPRO_01910	COG0559	Belongs to the binding-protein-dependent transport system permease family
CPRO_01930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CPRO_01950	COG0617	tRNA 3'-terminal CCA addition
CPRO_01990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPRO_02000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPRO_02010	COG1309	transcriptional regulator
CPRO_02080	COG0730	response to heat
CPRO_02100	COG1640	4-alpha-glucanotransferase
CPRO_02110	COG0367	asparagine synthase
CPRO_02150	COG0012	GTP binding
CPRO_02210	COG2385	sporulation resulting in formation of a cellular spore
CPRO_02240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CPRO_02270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPRO_02280	COG0569	domain protein
CPRO_02290	COG0653	protein targeting
CPRO_02310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CPRO_02330	COG1213	nucleotidyl transferase
CPRO_02360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CPRO_02380	COG0301	tRNA thio-modification
CPRO_02410	COG3584	3D domain protein
CPRO_02410	COG1388	LysM domain
CPRO_02420	COG0084	hydrolase, TatD family'
CPRO_02430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPRO_02430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPRO_02490	COG0840	transmembrane signaling receptor activity
CPRO_02500	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CPRO_02520	COG0659	secondary active sulfate transmembrane transporter activity
CPRO_02600	COG0534	Mate efflux family protein
CPRO_02610	COG2861	carbohydrate metabolic process
CPRO_02620	COG3331	DNA recombination
CPRO_02630	COG0312	modulator of DNA gyrase
CPRO_02640	COG0312	modulator of DNA gyrase
CPRO_02660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CPRO_02670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CPRO_02690	COG1610	YqeY-like protein
CPRO_02720	COG1122	ATPase activity
CPRO_02750	COG1702	phosphate starvation-inducible protein PhoH
CPRO_02760	COG1480	7TM receptor with intracellular HD hydrolase
CPRO_02770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CPRO_02780	COG0295	cytidine deaminase activity
CPRO_02790	COG1573	uracil-dna glycosylase
CPRO_02810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CPRO_02870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPRO_02870	COG0574	Belongs to the PEP-utilizing enzyme family
CPRO_02900	COG1677	Flagellar hook-basal body complex protein FliE
CPRO_02920	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CPRO_02940	COG1157	protein secretion by the type III secretion system
CPRO_03010	COG0789	Transcriptional regulator
CPRO_03070	COG0156	8-amino-7-oxononanoate synthase activity
CPRO_03090	COG0840	transmembrane signaling receptor activity
CPRO_03110	COG0735	belongs to the Fur family
CPRO_03130	COG1215	transferase activity, transferring glycosyl groups
CPRO_03190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CPRO_03230	COG1074	ATP-dependent DNA helicase activity
CPRO_03310	COG0802	atpase or kinase
CPRO_03320	COG1214	PFAM Peptidase M22, glycoprotease
CPRO_03330	COG0456	acetyltransferase
CPRO_03340	COG1067	ATP-dependent peptidase activity
CPRO_03360	COG2247	cell wall binding repeat
CPRO_03360	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPRO_03380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CPRO_03490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPRO_03500	COG1164	Oligoendopeptidase f
CPRO_03510	COG0297	glycogen (starch) synthase activity
CPRO_03600	COG1584	GPR1 FUN34 yaaH family protein
CPRO_03620	COG3620	sequence-specific DNA binding
CPRO_03640	COG0640	Transcriptional regulator
CPRO_03680	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CPRO_03750	COG1131	(ABC) transporter
CPRO_03770	COG1918	ferrous iron import across plasma membrane
CPRO_03770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CPRO_03790	COG1396	sequence-specific DNA binding
CPRO_03810	COG2340	Cysteine-rich secretory protein family
CPRO_03870	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPRO_03900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPRO_03930	COG1674	ftsk spoiiie
CPRO_03940	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CPRO_03960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPRO_03980	COG1058	Belongs to the CinA family
CPRO_03980	COG1546	Belongs to the CinA family
CPRO_04000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CPRO_04010	COG2137	regulation of response to DNA damage stimulus
CPRO_04040	COG2868	ribosomal protein
CPRO_04050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CPRO_04080	COG2199	diguanylate cyclase activity
CPRO_04100	COG0612	Peptidase, M16
CPRO_04110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CPRO_04120	COG0488	(ABC) transporter
CPRO_04130	COG1253	flavin adenine dinucleotide binding
CPRO_04140	COG1388	LysM domain
CPRO_04140	COG3858	chitin binding
CPRO_04160	COG0745	RESPONSE REGULATOR receiver
CPRO_04170	COG3850	Histidine kinase
CPRO_04170	COG5002	protein histidine kinase activity
CPRO_04210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPRO_04230	COG0037	tRNA processing
CPRO_04290	COG0335	large ribosomal subunit rRNA binding
CPRO_04340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPRO_04350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CPRO_04350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CPRO_04370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPRO_04390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPRO_04410	COG0569	domain protein
CPRO_04440	COG0481	GTPase activity
CPRO_04450	COG0745	RESPONSE REGULATOR receiver
CPRO_04460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CPRO_04510	COG0693	protein deglycase activity
CPRO_04540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CPRO_04560	COG1242	4 iron, 4 sulfur cluster binding
CPRO_04580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CPRO_04600	COG4492	Belongs to the UPF0735 family
CPRO_04610	COG0083	homoserine kinase activity
CPRO_04630	COG3546	catalase activity
CPRO_04700	COG1335	isochorismatase
CPRO_04710	COG3546	catalase activity
CPRO_04740	COG1268	BioY protein
CPRO_04760	COG1960	acyl-CoA dehydrogenase activity
CPRO_04770	COG2086	electron transfer activity
CPRO_04780	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CPRO_04790	COG2357	RelA SpoT domain protein
CPRO_04820	COG0557	exoribonuclease II activity
CPRO_04840	COG0531	amino acid
CPRO_04850	COG1342	Belongs to the UPF0251 family
CPRO_04870	COG1115	amino acid carrier protein
CPRO_04880	COG1115	amino acid carrier protein
CPRO_04890	COG1115	amino acid carrier protein
CPRO_04910	COG0438	transferase activity, transferring glycosyl groups
CPRO_04920	COG0210	DNA helicase
CPRO_04940	COG1131	(ABC) transporter
CPRO_04990	COG2720	vancomycin resistance protein
CPRO_05010	COG0436	Aminotransferase
CPRO_05030	COG1253	flavin adenine dinucleotide binding
CPRO_05050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CPRO_05080	COG1695	Transcriptional regulator
CPRO_05160	COG1918	ferrous iron import across plasma membrane
CPRO_05160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CPRO_05190	COG0840	transmembrane signaling receptor activity
CPRO_05210	COG0716	FMN binding
CPRO_05250	COG2357	RelA SpoT domain protein
CPRO_05290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPRO_05290	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CPRO_05320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPRO_05350	COG2848	UPF0210 protein
CPRO_05370	COG0051	transcription antitermination factor activity, RNA binding
CPRO_05390	COG0088	Forms part of the polypeptide exit tunnel
CPRO_05400	COG0089	rRNA binding
CPRO_05410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CPRO_05430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CPRO_05450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CPRO_05460	COG0255	Belongs to the universal ribosomal protein uL29 family
CPRO_05470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CPRO_05480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CPRO_05490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CPRO_05510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPRO_05520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CPRO_05530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CPRO_05560	COG1841	ribosomal large subunit assembly
CPRO_05570	COG0200	Binds to the 23S rRNA
CPRO_05580	COG0201	protein transport
CPRO_05590	COG0563	adenylate kinase activity
CPRO_05620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CPRO_05640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CPRO_05660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CPRO_05670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CPRO_05690	COG0203	ribosomal protein L17
CPRO_05720	COG1122	ATPase activity
CPRO_05740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CPRO_05750	COG0101	tRNA pseudouridine synthase activity
CPRO_05760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CPRO_05770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CPRO_05780	COG5505	Protein of unknown function (DUF819)
CPRO_05810	COG1534	Rna-binding protein
CPRO_05830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPRO_05840	COG0799	negative regulation of ribosome biogenesis
CPRO_05850	COG0069	glutamate synthase activity
CPRO_05850	COG0070	glutamate synthase
CPRO_05850	COG0067	glutamate synthase
CPRO_05860	COG0493	'glutamate synthase
CPRO_05870	COG0840	transmembrane signaling receptor activity
CPRO_05900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPRO_05940	COG1098	S1 RNA binding domain
CPRO_05960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPRO_05970	COG2011	ABC-type metal ion transport system permease component
CPRO_06000	COG0534	Mate efflux family protein
CPRO_06020	COG0191	fructose-bisphosphate aldolase activity
CPRO_06040	COG0251	oxidation-reduction process
CPRO_06090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CPRO_06100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CPRO_06120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CPRO_06130	COG0131	Imidazoleglycerol-phosphate dehydratase
CPRO_06140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CPRO_06150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CPRO_06160	COG0107	imidazoleglycerol-phosphate synthase activity
CPRO_06170	COG0140	phosphoribosyl-ATP diphosphatase activity
CPRO_06170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CPRO_06190	COG0386	Belongs to the glutathione peroxidase family
CPRO_06200	COG1846	Transcriptional regulator
CPRO_06350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPRO_06370	COG2205	protein histidine kinase activity
CPRO_06380	COG0745	RESPONSE REGULATOR receiver
CPRO_06450	COG0626	cystathionine gamma-synthase activity
CPRO_06460	COG0583	DNA-binding transcription factor activity
CPRO_06500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CPRO_06530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CPRO_06550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPRO_06560	COG0511	ligase activity, forming carbon-carbon bonds
CPRO_06570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CPRO_06580	COG0439	Biotin carboxylase
CPRO_06630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CPRO_06640	COG0268	Binds directly to 16S ribosomal RNA
CPRO_06660	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CPRO_06680	COG1247	-acetyltransferase
CPRO_06690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPRO_06700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CPRO_06710	COG0785	Cytochrome C biogenesis protein
CPRO_06730	COG0789	Transcriptional regulator
CPRO_06730	COG4978	Transcriptional regulator
CPRO_06750	COG1607	acyl-coa hydrolase
CPRO_06770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CPRO_06810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPRO_06820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPRO_06860	COG1940	carbohydrate kinase activity
CPRO_06880	COG0427	acetyl-CoA hydrolase
CPRO_06890	COG0590	tRNA wobble adenosine to inosine editing
CPRO_06900	COG0242	peptide deformylase activity
CPRO_06910	COG0632	four-way junction helicase activity
CPRO_06920	COG2255	four-way junction helicase activity
CPRO_06950	COG1592	Rubrerythrin
CPRO_06960	COG1489	DNA binding
CPRO_06970	COG1686	Belongs to the peptidase S11 family
CPRO_06980	COG2199	diguanylate cyclase activity
CPRO_07040	COG0475	glutathione-regulated potassium exporter activity
CPRO_07070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPRO_07110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CPRO_07130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPRO_07140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CPRO_07160	COG2226	methyltransferase
CPRO_07170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CPRO_07200	COG1269	ATP hydrolysis coupled proton transport
CPRO_07210	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPRO_07280	COG0436	Aminotransferase
CPRO_07300	COG2267	carboxylic ester hydrolase activity
CPRO_07310	COG2502	aspartate--ammonia ligase
CPRO_07340	COG2385	sporulation resulting in formation of a cellular spore
CPRO_07340	COG2247	cell wall binding repeat
CPRO_07360	COG0028	Belongs to the TPP enzyme family
CPRO_07370	COG0440	acetolactate synthase activity
CPRO_07380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CPRO_07400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CPRO_07420	COG0582	viral genome integration into host DNA
CPRO_07630	COG1278	Cold shock
CPRO_07680	COG3728	DNA packaging
CPRO_07990	COG0737	Belongs to the 5'-nucleotidase family
CPRO_08000	COG0737	Belongs to the 5'-nucleotidase family
CPRO_08050	COG2894	cell division
CPRO_08070	COG3191	aminopeptidase activity
CPRO_08080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPRO_08100	COG3879	Bacterial protein of unknown function (DUF881)
CPRO_08110	COG3856	small basic protein
CPRO_08120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CPRO_08130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CPRO_08140	COG0573	inorganic phosphate transmembrane transporter activity
CPRO_08150	COG0581	inorganic phosphate transmembrane transporter activity
CPRO_08170	COG0704	Plays a role in the regulation of phosphate uptake
CPRO_08200	COG5002	protein histidine kinase activity
CPRO_08230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CPRO_08330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CPRO_08360	COG0768	penicillin binding
CPRO_08410	COG3437	response regulator, receiver
CPRO_08420	COG5002	protein histidine kinase activity
CPRO_08420	COG2205	protein histidine kinase activity
CPRO_08420	COG0784	Response regulator, receiver
CPRO_08440	COG2832	Protein of unknown function (DUF454)
CPRO_08460	COG4988	ABC transporter
CPRO_08580	COG1388	LysM domain
CPRO_08580	COG1705	Flagellar rod assembly protein muramidase FlgJ
CPRO_08610	COG3628	GPW Gp25 family protein
CPRO_08620	COG3299	homolog of phage Mu protein gp47
CPRO_08710	COG2040	homocysteine
CPRO_08790	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CPRO_08800	COG0298	carbon dioxide binding
CPRO_08810	COG0409	Hydrogenase expression formation protein
CPRO_08820	COG0309	Hydrogenase expression formation protein (HypE)
CPRO_08850	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CPRO_08860	COG0473	3-isopropylmalate dehydrogenase activity
CPRO_08870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CPRO_08880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPRO_08900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CPRO_08910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPRO_08910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPRO_08920	COG0237	dephospho-CoA kinase activity
CPRO_08940	COG0747	negative chemotaxis
CPRO_08950	COG0537	adenosine 5'-monophosphoramidase activity
CPRO_08960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPRO_09090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CPRO_09110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPRO_09130	COG0494	nUDIX hydrolase
CPRO_09160	COG2003	Belongs to the UPF0758 family
CPRO_09190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPRO_09230	COG0367	asparagine synthase
CPRO_09280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CPRO_09290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPRO_09380	COG0473	3-isopropylmalate dehydrogenase activity
CPRO_09400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CPRO_09410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPRO_09420	COG2188	Transcriptional regulator
CPRO_09430	COG0129	dihydroxy-acid dehydratase activity
CPRO_09440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPRO_09480	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPRO_09480	COG3409	Peptidoglycan-binding domain 1 protein
CPRO_09490	COG2205	protein histidine kinase activity
CPRO_09490	COG0784	Response regulator, receiver
CPRO_09550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CPRO_09580	COG3681	Belongs to the UPF0597 family
CPRO_09600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPRO_09610	COG0187	DNA topoisomerase II activity
CPRO_09640	COG0519	Catalyzes the synthesis of GMP from XMP
CPRO_09660	COG0800	Aldolase
CPRO_09680	COG1312	Catalyzes the dehydration of D-mannonate
CPRO_09690	COG0246	Mannitol dehydrogenase
CPRO_09700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPRO_09710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CPRO_09720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPRO_09730	COG1063	alcohol dehydrogenase
CPRO_09740	COG1802	Transcriptional regulator
CPRO_09760	COG0277	FAD linked oxidase domain protein
CPRO_09780	COG2197	response regulator
CPRO_09840	COG1737	Transcriptional regulator
CPRO_09850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPRO_09870	COG1129	ABC transporter
CPRO_09880	COG1172	Belongs to the binding-protein-dependent transport system permease family
CPRO_09890	COG1940	carbohydrate kinase activity
CPRO_09900	COG0191	fructose-bisphosphate aldolase activity
CPRO_09910	COG0205	6-phosphofructokinase activity
CPRO_09930	COG1309	transcriptional regulator
CPRO_09940	COG1131	(ABC) transporter
CPRO_10060	COG0024	Methionine aminopeptidase
CPRO_10100	COG3706	GGDEF domain
CPRO_10120	COG0765	amino acid transport
CPRO_10130	COG1126	abc transporter atp-binding protein
CPRO_10170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CPRO_10180	COG1854	S-ribosylhomocysteine lyase activity
CPRO_10190	COG0626	cystathionine gamma-synthase activity
CPRO_10200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPRO_10210	COG0583	DNA-binding transcription factor activity
CPRO_10240	COG2011	ABC-type metal ion transport system permease component
CPRO_10270	COG0674	pyruvate-flavodoxin oxidoreductase activity
CPRO_10280	COG1013	pyruvate-flavodoxin oxidoreductase activity
CPRO_10290	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CPRO_10310	COG1959	2 iron, 2 sulfur cluster binding
CPRO_10350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CPRO_10360	COG1104	cysteine desulfurase activity
CPRO_10370	COG0037	tRNA processing
CPRO_10380	COG0460	homoserine dehydrogenase
CPRO_10400	COG1191	sigma factor activity
CPRO_10450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CPRO_10460	COG0022	dehydrogenase e1 component
CPRO_10470	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPRO_10480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPRO_10510	COG4120	Belongs to the binding-protein-dependent transport system permease family
CPRO_10520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CPRO_10540	COG1959	2 iron, 2 sulfur cluster binding
CPRO_10550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPRO_10610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CPRO_10620	COG0367	asparagine synthase
CPRO_10630	COG3069	C4-dicarboxylate transmembrane transporter activity
CPRO_10640	COG0583	DNA-binding transcription factor activity
CPRO_10650	COG1454	alcohol dehydrogenase
CPRO_10650	COG1012	belongs to the aldehyde dehydrogenase family
CPRO_10660	COG0513	Belongs to the DEAD box helicase family
CPRO_10670	COG1968	undecaprenyl-diphosphatase activity
CPRO_10680	COG1285	pathogenesis
CPRO_10740	COG0217	transcriptional regulatory protein
CPRO_10750	COG0582	viral genome integration into host DNA
CPRO_10920	COG0582	viral genome integration into host DNA
CPRO_10930	COG3728	DNA packaging
CPRO_10930	COG5484	DNA packaging
CPRO_11170	COG2268	Band 7 protein
CPRO_11230	COG2205	protein histidine kinase activity
CPRO_11240	COG0577	efflux transmembrane transporter activity
CPRO_11240	COG1136	(ABC) transporter
CPRO_11270	COG0275	rRNA processing
CPRO_11310	COG3973	AAA domain
CPRO_11320	COG2207	Transcriptional regulator
CPRO_11390	COG2226	methyltransferase
CPRO_11410	COG3708	Transcriptional regulator
CPRO_11410	COG2207	Transcriptional regulator
CPRO_11460	COG1132	(ABC) transporter
CPRO_11490	COG3279	Response regulator of the LytR AlgR family
CPRO_11510	COG1704	LemA family
CPRO_11550	COG0642	Histidine kinase
CPRO_11560	COG1136	(ABC) transporter
CPRO_11570	COG0577	efflux transmembrane transporter activity
CPRO_11600	COG1876	peptidase activity
CPRO_11640	COG0509	glycine decarboxylation via glycine cleavage system
CPRO_11670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPRO_11720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CPRO_11740	COG0114	fumarate hydratase activity
CPRO_11760	COG0281	malic enzyme
CPRO_11770	COG1671	Belongs to the UPF0178 family
CPRO_11790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPRO_11810	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CPRO_11840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CPRO_11860	COG0077	Prephenate dehydratase
CPRO_11860	COG1605	Chorismate mutase
CPRO_11870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPRO_11890	COG2001	Belongs to the MraZ family
CPRO_11910	COG0275	rRNA processing
CPRO_11930	COG0768	penicillin binding
CPRO_11940	COG0768	penicillin binding
CPRO_11960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CPRO_11980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPRO_11990	COG0772	Belongs to the SEDS family
CPRO_12010	COG0525	valine-tRNA ligase activity
CPRO_12030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CPRO_12050	COG4496	protein, YerC YecD
CPRO_12080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPRO_12090	COG1116	anion transmembrane transporter activity
CPRO_12180	COG0582	viral genome integration into host DNA
CPRO_12210	COG1114	Component of the transport system for branched-chain amino acids
CPRO_12230	COG1902	pentaerythritol trinitrate reductase activity
CPRO_12230	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPRO_12240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPRO_12260	COG2210	Belongs to the sulfur carrier protein TusA family
CPRO_12280	COG2201	protein-glutamate methylesterase activity
CPRO_12300	COG1141	Ferredoxin
CPRO_12320	COG1151	hydroxylamine reductase activity
CPRO_12370	COG1115	amino acid carrier protein
CPRO_12430	COG3620	sequence-specific DNA binding
CPRO_12470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CPRO_12490	COG1328	CTP reductase activity
CPRO_12490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CPRO_12500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CPRO_12510	COG1307	EDD domain protein, DegV family
CPRO_12520	COG1329	Transcriptional regulator
CPRO_12530	COG4956	integral membrane protein (PIN domain superfamily)
CPRO_12540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CPRO_12550	COG0328	RNA-DNA hybrid ribonuclease activity
CPRO_12560	COG1278	Cold shock
CPRO_12580	COG0542	response to heat
CPRO_12590	COG2203	Gaf domain
CPRO_12590	COG2199	diguanylate cyclase activity
CPRO_12620	COG1739	Uncharacterized protein family UPF0029
CPRO_12630	COG1917	Cupin 2, conserved barrel domain protein
CPRO_12630	COG2207	Transcriptional regulator
CPRO_12640	COG0697	spore germination
CPRO_12670	COG2378	regulation of single-species biofilm formation
CPRO_12690	COG0456	acetyltransferase
CPRO_12720	COG2379	hydroxypyruvate reductase
CPRO_12730	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CPRO_12740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPRO_12780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CPRO_12800	COG1686	Belongs to the peptidase S11 family
CPRO_12820	COG0551	DNA topoisomerase type I activity
CPRO_12820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPRO_12830	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CPRO_12850	COG2244	polysaccharide biosynthetic process
CPRO_12860	COG0531	amino acid
CPRO_12870	COG1863	multisubunit Na H antiporter MnhE subunit
CPRO_12930	COG0651	ATP synthesis coupled electron transport
CPRO_12940	COG0651	ATP synthesis coupled electron transport
CPRO_12960	COG0651	ATP synthesis coupled electron transport
CPRO_13010	COG2199	diguanylate cyclase activity
CPRO_13120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPRO_13150	COG4474	Belongs to the UPF0398 family
CPRO_13360	COG3177	Filamentation induced by cAMP protein fic
CPRO_13420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPRO_13440	COG0582	viral genome integration into host DNA
CPRO_13490	COG2252	PERMEase
CPRO_13500	COG0205	6-phosphofructokinase activity
CPRO_13520	COG3103	Sh3 type 3 domain protein
CPRO_13520	COG0366	Alpha amylase catalytic
CPRO_13530	COG0564	pseudouridine synthase activity
CPRO_13540	COG0542	response to heat
CPRO_13570	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CPRO_13610	COG0095	Lipoate-protein ligase
CPRO_13730	COG2002	toxin-antitoxin pair type II binding
CPRO_13970	COG0739	heme binding
CPRO_13970	COG1196	nuclear chromosome segregation
CPRO_13970	COG0741	lytic transglycosylase activity
CPRO_14160	COG0326	Molecular chaperone. Has ATPase activity
CPRO_14260	COG2135	peptidase activity
CPRO_14270	COG0726	polysaccharide deacetylase
CPRO_14280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPRO_14280	COG1522	sequence-specific DNA binding
CPRO_14360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CPRO_14400	COG3118	belongs to the thioredoxin family
CPRO_14430	COG0583	DNA-binding transcription factor activity
CPRO_14460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CPRO_14540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CPRO_14630	COG2197	response regulator
CPRO_14650	COG1012	belongs to the aldehyde dehydrogenase family
CPRO_14660	COG1757	Na H antiporter
CPRO_14670	COG1595	DNA-templated transcription, initiation
CPRO_14750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CPRO_14800	COG1649	PFAM Uncharacterised BCR, COG1649
CPRO_14810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPRO_14840	COG1846	Transcriptional regulator
CPRO_14850	COG0840	transmembrane signaling receptor activity
CPRO_14930	COG0038	chloride channel
CPRO_14940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPRO_14950	COG0765	amino acid transport
CPRO_14960	COG1126	abc transporter atp-binding protein
CPRO_14970	COG0393	Putative heavy-metal-binding
CPRO_14980	COG0598	Magnesium transport protein CorA
CPRO_15000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CPRO_15010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPRO_15020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CPRO_15110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPRO_15120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CPRO_15140	COG0420	3'-5' exonuclease activity
CPRO_15150	COG0419	ATPase involved in DNA repair
CPRO_15160	COG0419	ATPase involved in DNA repair
CPRO_15180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CPRO_15190	COG2873	o-acetylhomoserine
CPRO_15210	COG2385	sporulation resulting in formation of a cellular spore
CPRO_15230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CPRO_15240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CPRO_15260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPRO_15260	COG0072	phenylalanine-tRNA ligase activity
CPRO_15300	COG2244	polysaccharide biosynthetic process
CPRO_15320	COG0322	excinuclease ABC activity
CPRO_15330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CPRO_15340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CPRO_15350	COG1660	Displays ATPase and GTPase activities
CPRO_15360	COG1481	regulation of sporulation
CPRO_15370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPRO_15380	COG0116	Belongs to the methyltransferase superfamily
CPRO_15390	COG0343	queuine tRNA-ribosyltransferase activity
CPRO_15400	COG1862	Preprotein translocase
CPRO_15460	COG1957	nucleoside hydrolase
CPRO_15480	COG1773	rubredoxin
CPRO_15480	COG1592	Rubrerythrin
CPRO_15510	COG4942	peptidase
CPRO_15530	COG0495	leucyl-tRNA aminoacylation
CPRO_15540	COG1132	(ABC) transporter
CPRO_15550	COG1132	(ABC) transporter
CPRO_15560	COG1846	Transcriptional regulator
CPRO_15590	COG2176	DNA-directed DNA polymerase activity
CPRO_15600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CPRO_15630	COG4589	Belongs to the CDS family
CPRO_15640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPRO_15650	COG0233	cytoplasmic translational termination
CPRO_15670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CPRO_15680	COG0052	Belongs to the universal ribosomal protein uS2 family
CPRO_15690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPRO_15700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CPRO_15700	COG0758	DNA mediated transformation
CPRO_15710	COG0606	chelatase, subunit chli
CPRO_15730	COG0840	transmembrane signaling receptor activity
CPRO_15760	COG1404	Belongs to the peptidase S8 family
CPRO_15790	COG2200	EAL domain
CPRO_15790	COG2199	diguanylate cyclase activity
CPRO_15810	COG0688	phosphatidylethanolamine metabolic process
CPRO_15820	COG1183	phosphatidylcholine synthase activity
CPRO_15850	COG1114	Component of the transport system for branched-chain amino acids
CPRO_15860	COG0436	Aminotransferase
CPRO_15870	COG0427	acetyl-CoA hydrolase
CPRO_15890	COG1144	Oxidoreductase
CPRO_15900	COG1802	Transcriptional regulator
CPRO_15930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CPRO_15940	COG0352	thiamine-phosphate diphosphorylase activity
CPRO_15960	COG2022	thiamine diphosphate biosynthetic process
CPRO_15970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CPRO_16000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CPRO_16010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CPRO_16030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPRO_16040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CPRO_16060	COG1309	transcriptional regulator
CPRO_16070	COG0450	alkyl hydroperoxide reductase
CPRO_16140	COG1151	hydroxylamine reductase activity
CPRO_16150	COG2610	gluconate transmembrane transporter activity
CPRO_16160	COG1024	Enoyl-CoA hydratase
CPRO_16170	COG4670	ketone body catabolic process
CPRO_16190	COG1013	pyruvate-flavodoxin oxidoreductase activity
CPRO_16190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CPRO_16190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CPRO_16190	COG0674	pyruvate-flavodoxin oxidoreductase activity
CPRO_16210	COG0723	plastoquinol--plastocyanin reductase activity
CPRO_16210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPRO_16220	COG3546	catalase activity
CPRO_16260	COG1607	acyl-coa hydrolase
CPRO_16270	COG1012	belongs to the aldehyde dehydrogenase family
CPRO_16290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPRO_16350	COG0733	neurotransmitter:sodium symporter activity
CPRO_16380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CPRO_16420	COG1733	regulation of RNA biosynthetic process
CPRO_16440	COG2205	protein histidine kinase activity
CPRO_16450	COG0745	RESPONSE REGULATOR receiver
CPRO_16470	COG0569	domain protein
CPRO_16480	COG0569	domain protein
CPRO_16490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPRO_16500	COG2080	2 iron, 2 sulfur cluster binding
CPRO_16520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CPRO_16560	COG0412	Dienelactone hydrolase
CPRO_16660	COG0277	FAD linked oxidase domain protein
CPRO_16720	COG0701	Predicted permease
CPRO_16740	COG0798	PFAM Bile acid sodium symporter
CPRO_16760	COG0390	transport system, permease component
CPRO_16770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPRO_16790	COG3708	Transcriptional regulator
CPRO_16790	COG2207	Transcriptional regulator
CPRO_16820	COG5002	protein histidine kinase activity
CPRO_16830	COG0745	RESPONSE REGULATOR receiver
CPRO_16870	COG0105	UTP biosynthetic process
CPRO_16910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPRO_16930	COG3191	aminopeptidase activity
CPRO_16960	COG4145	pantothenate transmembrane transporter activity
CPRO_16980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CPRO_16990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CPRO_17000	COG1414	Transcriptional regulator
CPRO_17010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CPRO_17040	COG0840	transmembrane signaling receptor activity
CPRO_17150	COG0745	RESPONSE REGULATOR receiver
CPRO_17200	COG2208	phosphoserine phosphatase activity
CPRO_17200	COG2770	Histidine kinase
CPRO_17230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CPRO_17230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CPRO_17240	COG1366	Belongs to the anti-sigma-factor antagonist family
CPRO_17250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CPRO_17280	COG2274	protein secretion by the type I secretion system
CPRO_17310	COG2199	diguanylate cyclase activity
CPRO_17370	COG1309	transcriptional regulator
CPRO_17390	COG5609	conserved protein (DUF2294)
CPRO_17440	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPRO_17470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CPRO_17480	COG0303	'Molybdopterin
CPRO_17490	COG0303	'Molybdopterin
CPRO_17580	COG0148	phosphopyruvate hydratase activity
CPRO_17720	COG0210	DNA helicase
CPRO_17730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CPRO_17790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPRO_17840	COG1924	4 iron, 4 sulfur cluster binding
CPRO_17920	COG1773	rubredoxin
CPRO_17960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPRO_18030	COG1151	hydroxylamine reductase activity
CPRO_18110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CPRO_18120	COG2195	Cleaves the N-terminal amino acid of tripeptides
CPRO_18130	COG1288	antiporter activity
CPRO_18140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPRO_18160	COG3706	GGDEF domain
CPRO_18170	COG2199	diguanylate cyclase activity
CPRO_18170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CPRO_18180	COG0450	alkyl hydroperoxide reductase
CPRO_18190	COG0697	spore germination
CPRO_18220	COG3328	transposase activity
CPRO_18230	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CPRO_18310	COG3012	SEC-C Motif Domain Protein
CPRO_18330	COG0210	DNA helicase
CPRO_18340	COG1196	nuclear chromosome segregation
CPRO_18520	COG2826	transposase and inactivated derivatives, IS30 family
CPRO_18550	COG4443	Transcriptional Coactivator p15 (PC4)
CPRO_18640	COG1525	nuclease
CPRO_18750	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CPRO_18810	COG0791	NLP P60 protein
CPRO_18810	COG0741	lytic transglycosylase activity
CPRO_18950	COG1475	DNA binding
CPRO_18960	COG1192	Involved in chromosome partitioning
CPRO_18980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPRO_19070	COG1309	transcriptional regulator
CPRO_19080	COG1943	Transposase
CPRO_19110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPRO_19180	COG0791	NLP P60 protein
CPRO_19190	COG2226	methyltransferase
CPRO_19230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPRO_19250	COG0789	Transcriptional regulator
CPRO_19390	COG2378	regulation of single-species biofilm formation
CPRO_19400	COG2378	regulation of single-species biofilm formation
CPRO_19420	COG0488	(ABC) transporter
CPRO_19430	COG0488	(ABC) transporter
CPRO_19440	COG0789	Transcriptional regulator
CPRO_19450	COG1131	(ABC) transporter
CPRO_19540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CPRO_19550	COG3344	reverse transcriptase
CPRO_19640	COG2088	sporulation resulting in formation of a cellular spore
CPRO_19700	COG4974	Belongs to the 'phage' integrase family
CPRO_19710	COG4974	Belongs to the 'phage' integrase family
CPRO_19720	COG4974	Belongs to the 'phage' integrase family
CPRO_19850	COG0517	IMP dehydrogenase activity
CPRO_20070	COG3481	metal-dependent phosphohydrolase, HD sub domain
CPRO_20120	COG0004	ammonium transporteR
CPRO_20130	COG1191	sigma factor activity
CPRO_20180	COG1283	sodium-dependent phosphate transmembrane transporter activity
CPRO_20190	COG0527	aspartate kinase activity
CPRO_20190	COG0460	homoserine dehydrogenase
CPRO_20220	COG0010	Belongs to the arginase family
CPRO_20230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CPRO_20240	COG1982	Orn Lys Arg decarboxylase major
CPRO_20260	COG0583	DNA-binding transcription factor activity
CPRO_20270	COG1063	alcohol dehydrogenase
CPRO_20280	COG5002	protein histidine kinase activity
CPRO_20290	COG0745	RESPONSE REGULATOR receiver
CPRO_20310	COG0038	chloride channel
CPRO_20320	COG2964	Protein conserved in bacteria
CPRO_20330	COG1584	GPR1 FUN34 yaaH family protein
CPRO_20340	COG0336	Belongs to the RNA methyltransferase TrmD family
CPRO_20350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CPRO_20360	COG1837	Belongs to the UPF0109 family
CPRO_20370	COG0228	four-way junction DNA binding
CPRO_20380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CPRO_20400	COG0406	alpha-ribazole phosphatase activity
CPRO_20430	COG1854	S-ribosylhomocysteine lyase activity
CPRO_20450	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CPRO_20460	COG1760	l-serine dehydratase
CPRO_20470	COG1760	l-serine dehydratase
CPRO_20480	COG0459	protein refolding
CPRO_20490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CPRO_20510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPRO_20520	COG0822	iron-sulfur transferase activity
CPRO_20540	COG1396	sequence-specific DNA binding
CPRO_20550	COG0497	DNA recombination
CPRO_20560	COG1438	arginine binding
CPRO_20570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CPRO_20580	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CPRO_20590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CPRO_20600	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CPRO_20620	COG1722	exodeoxyribonuclease VII activity
CPRO_20630	COG1570	exodeoxyribonuclease VII activity
CPRO_20650	COG1302	Protein conserved in bacteria
CPRO_20730	COG3854	ATPases associated with a variety of cellular activities
CPRO_20740	COG3279	Response regulator of the LytR AlgR family
CPRO_20800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CPRO_20840	COG0658	competence protein
CPRO_20840	COG2333	competence protein COMEC
CPRO_20860	COG5002	protein histidine kinase activity
CPRO_20870	COG0745	RESPONSE REGULATOR receiver
CPRO_20890	COG1686	Belongs to the peptidase S11 family
CPRO_20900	COG0791	NLP P60 protein
CPRO_20900	COG1388	LysM domain
CPRO_20910	COG1132	(ABC) transporter
CPRO_20950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPRO_20960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CPRO_20970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPRO_20970	COG2169	Transcriptional regulator
CPRO_20980	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CPRO_21210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPRO_21420	COG1191	sigma factor activity
CPRO_21440	COG1366	Belongs to the anti-sigma-factor antagonist family
CPRO_21450	COG1191	sigma factor activity
CPRO_21520	COG0493	'glutamate synthase
CPRO_21540	COG1953	Uracil, thiamine, allantoin
CPRO_21560	COG4978	Transcriptional regulator
CPRO_21560	COG0789	Transcriptional regulator
CPRO_21590	COG1607	acyl-coa hydrolase
CPRO_21600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CPRO_21670	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CPRO_21690	COG1459	type II secretion system
CPRO_21770	COG1846	Transcriptional regulator
CPRO_21800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CPRO_21880	COG1194	a g-specific adenine glycosylase
CPRO_21890	COG2116	formate transmembrane transporter activity
CPRO_21900	COG3048	D-serine ammonia-lyase activity
CPRO_21920	COG2205	protein histidine kinase activity
CPRO_21930	COG0745	RESPONSE REGULATOR receiver
CPRO_21990	COG0552	protein localization to endoplasmic reticulum
CPRO_22000	COG1196	nuclear chromosome segregation
CPRO_22030	COG0564	pseudouridine synthase activity
CPRO_22090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPRO_22120	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPRO_22130	COG3199	ATP-NAD kinase
CPRO_22140	COG0022	dehydrogenase e1 component
CPRO_22150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CPRO_22250	COG1733	regulation of RNA biosynthetic process
CPRO_22290	COG1396	sequence-specific DNA binding
CPRO_22300	COG1882	Formate acetyltransferase
CPRO_22360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPRO_22370	COG1115	amino acid carrier protein
CPRO_22420	COG3688	RNA-binding protein containing a PIN domain
CPRO_22430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPRO_22450	COG0215	cysteine-tRNA ligase activity
CPRO_22460	COG1045	serine acetyltransferase
CPRO_22470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CPRO_22610	COG4864	UPF0365 protein
CPRO_22640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CPRO_22650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPRO_22650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CPRO_22660	COG5002	protein histidine kinase activity
CPRO_22680	COG0745	RESPONSE REGULATOR receiver
CPRO_22690	COG1193	negative regulation of DNA recombination
CPRO_22700	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CPRO_22730	COG1011	Hydrolase
CPRO_22800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPRO_22810	COG1162	GTPase activity
CPRO_22820	COG0515	serine threonine protein kinase
CPRO_22820	COG2815	serine threonine protein kinase
CPRO_22820	COG2815	serine threonine protein kinase
CPRO_22820	COG0515	serine threonine protein kinase
CPRO_22840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CPRO_22850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPRO_22850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPRO_22860	COG2738	Putative neutral zinc metallopeptidase
CPRO_22890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CPRO_22900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CPRO_22920	COG0194	GDP metabolic process
CPRO_22940	COG1561	YicC-like family, N-terminal region
CPRO_22980	COG1530	ribonuclease E activity
CPRO_23000	COG0739	heme binding
CPRO_23020	COG1162	GTPase activity
CPRO_23030	COG1683	Conserved Protein
CPRO_23050	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CPRO_23060	COG1132	(ABC) transporter
CPRO_23080	COG0346	lactoylglutathione lyase activity
CPRO_23360	COG2084	Dehydrogenase
CPRO_23380	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPRO_23390	COG0022	dehydrogenase e1 component
CPRO_23400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CPRO_23430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPRO_23460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPRO_23470	COG0151	Belongs to the GarS family
CPRO_23480	COG0138	bifunctional purine biosynthesis protein purh
CPRO_23490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPRO_23510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CPRO_23530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CPRO_23540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CPRO_23550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CPRO_23560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPRO_23580	COG0543	2 iron, 2 sulfur cluster binding
CPRO_23590	COG0167	dihydroorotate dehydrogenase activity
CPRO_23600	COG0284	orotidine-5'-phosphate decarboxylase activity
CPRO_23620	COG0540	Belongs to the ATCase OTCase family
CPRO_23680	COG0628	permease
CPRO_23690	COG2195	Cleaves the N-terminal amino acid of tripeptides
CPRO_23700	COG0571	ribonuclease III activity
CPRO_23710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPRO_23750	COG0280	phosphate acetyltransferase
CPRO_23780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CPRO_23790	COG0416	fatty acid biosynthetic process
CPRO_23810	COG3314	Sporulation integral membrane protein YlbJ
CPRO_23830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CPRO_23840	COG0742	ribosomal rna small subunit methyltransferase
CPRO_23890	COG0577	efflux transmembrane transporter activity
CPRO_23890	COG1136	(ABC) transporter
CPRO_23900	COG1136	(ABC) transporter
CPRO_23910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPRO_23940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CPRO_24000	COG4974	Belongs to the 'phage' integrase family
CPRO_24330	COG0037	tRNA processing
CPRO_24400	COG2002	toxin-antitoxin pair type II binding
CPRO_24480	COG2856	Zn peptidase
CPRO_24590	COG0535	radical SAM domain protein
CPRO_24620	COG1278	Cold shock
CPRO_24630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CPRO_24660	COG1461	Dihydroxyacetone kinase
CPRO_24670	COG1302	Protein conserved in bacteria
CPRO_24700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPRO_24710	COG1028	Short-chain dehydrogenase reductase Sdr
CPRO_24720	COG1943	Transposase
CPRO_24880	COG2195	Cleaves the N-terminal amino acid of tripeptides
CPRO_24890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CPRO_24900	COG0693	protein deglycase activity
CPRO_24910	COG4974	Belongs to the 'phage' integrase family
CPRO_24920	COG1300	Membrane
CPRO_24970	COG0750	zinc metalloprotease
CPRO_25010	COG0148	phosphopyruvate hydratase activity
CPRO_25020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CPRO_25030	COG0149	triose-phosphate isomerase activity
CPRO_25050	COG0126	phosphoglycerate kinase activity
CPRO_25090	COG2339	peptidase activity
CPRO_25100	COG0577	efflux transmembrane transporter activity
CPRO_25120	COG1136	(ABC) transporter
CPRO_25140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPRO_25160	COG2155	Conserved Protein
CPRO_25170	COG0612	Peptidase, M16
CPRO_25180	COG1185	polyribonucleotide nucleotidyltransferase activity
CPRO_25190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CPRO_25210	COG0196	riboflavin kinase activity
CPRO_25220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPRO_25250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CPRO_25270	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CPRO_25280	COG0195	Participates in both transcription termination and antitermination
CPRO_25300	COG1811	Na channel or pump
CPRO_25310	COG1126	abc transporter atp-binding protein
CPRO_25320	COG0765	amino acid transport
CPRO_25350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPRO_25380	COG0539	negative regulation of cytoplasmic translation
CPRO_25380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CPRO_25390	COG0204	Acyl-transferase
CPRO_25400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPRO_25410	COG2081	HI0933 family
CPRO_25420	COG0406	alpha-ribazole phosphatase activity
CPRO_25430	COG1187	pseudouridine synthase activity
CPRO_25440	COG1686	Belongs to the peptidase S11 family
CPRO_25460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPRO_25470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CPRO_25530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CPRO_25570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CPRO_25620	COG1966	Carbon starvation protein
CPRO_25630	COG0708	Exodeoxyribonuclease III
CPRO_25660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CPRO_25670	COG0159	tryptophan synthase activity
CPRO_25690	COG0135	phosphoribosylanthranilate isomerase activity
CPRO_25710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CPRO_25720	COG0512	Glutamine amidotransferase of anthranilate synthase
CPRO_25750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPRO_25760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CPRO_25770	COG0484	heat shock protein binding
CPRO_25780	COG0443	Heat shock 70 kDa protein
CPRO_25790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CPRO_25810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPRO_25820	COG1368	sulfuric ester hydrolase activity
CPRO_25860	COG1476	TRANSCRIPTIONal
CPRO_25910	COG0006	proline dipeptidase activity
CPRO_25920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CPRO_25970	COG0470	DNA polymerase III
CPRO_25970	COG1067	ATP-dependent peptidase activity
CPRO_25980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPRO_25990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPRO_26000	COG0049	tRNA binding
CPRO_26020	COG1136	(ABC) transporter
CPRO_26020	COG0577	efflux transmembrane transporter activity
CPRO_26050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CPRO_26070	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CPRO_26090	COG0222	ribosome binding
CPRO_26130	COG0250	Participates in transcription elongation, termination and antitermination
CPRO_26170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPRO_26190	COG0793	Belongs to the peptidase S41A family
CPRO_26200	COG2177	Part of the ABC transporter FtsEX involved in
CPRO_26210	COG2884	Cell division ATP-binding protein ftsE
CPRO_26220	COG2508	Transcriptional regulator
CPRO_26230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPRO_26280	COG0438	transferase activity, transferring glycosyl groups
CPRO_26290	COG0728	peptidoglycan biosynthetic process
CPRO_26360	COG1316	TRANSCRIPTIONal
CPRO_26380	COG0733	neurotransmitter:sodium symporter activity
CPRO_26390	COG2239	Acts as a magnesium transporter
CPRO_26410	COG0305	Participates in initiation and elongation during chromosome replication
CPRO_26420	COG0359	binds to the 23S rRNA
CPRO_26430	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CPRO_26470	COG0714	Associated with various cellular activities
CPRO_26480	COG0628	permease
CPRO_26510	COG2002	toxin-antitoxin pair type II binding
CPRO_26520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CPRO_26530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CPRO_26560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CPRO_26580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPRO_26590	COG3906	Belongs to the UPF0473 family
CPRO_26620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPRO_26630	COG0561	phosphatase activity
CPRO_26660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPRO_26670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CPRO_26680	COG0668	transmembrane transport
CPRO_26730	COG2217	Heavy metal translocating P-type atpase
CPRO_26740	COG0640	Transcriptional regulator
CPRO_26750	COG0583	DNA-binding transcription factor activity
CPRO_26780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CPRO_26790	COG0193	aminoacyl-tRNA hydrolase activity
CPRO_26800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CPRO_26830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPRO_26860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPRO_26870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CPRO_26880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CPRO_26890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPRO_26930	COG5002	protein histidine kinase activity
CPRO_26940	COG0745	RESPONSE REGULATOR receiver
CPRO_26980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CPRO_26990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CPRO_27000	COG1774	PSP1 C-terminal conserved region
CPRO_27010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CPRO_27020	COG3870	Protein conserved in bacteria
CPRO_27030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CPRO_27040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CPRO_27060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPRO_27080	COG0698	ribose 5-phosphate isomerase
CPRO_27090	COG0009	L-threonylcarbamoyladenylate synthase
CPRO_27100	COG0653	protein targeting
CPRO_27150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPRO_27170	COG0537	adenosine 5'-monophosphoramidase activity
CPRO_27210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPRO_27230	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CPRO_27240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CPRO_27260	COG1040	competence protein
CPRO_27270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CPRO_27280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CPRO_27370	COG0726	polysaccharide deacetylase
CPRO_27390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPRO_27400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPRO_27420	COG2233	PERMEase
CPRO_27430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CPRO_27480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CPRO_27480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CPRO_27520	COG0037	tRNA processing
CPRO_27560	COG0426	domain, Protein
CPRO_27560	COG1773	rubredoxin
CPRO_27570	COG0166	Belongs to the GPI family
CPRO_27590	COG1802	Transcriptional regulator
CPRO_27600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CPRO_27630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPRO_27630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPRO_27640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CPRO_27650	COG0628	permease
CPRO_27680	COG0024	Methionine aminopeptidase
CPRO_28080	COG2431	L-lysine efflux transmembrane transporter activity
CPRO_28100	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CPRO_28110	COG0488	(ABC) transporter
CPRO_28130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CPRO_28150	COG0371	Dehydrogenase
CPRO_28160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CPRO_28170	COG2086	electron transfer activity
CPRO_28180	COG1960	acyl-CoA dehydrogenase activity
CPRO_28190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CPRO_28190	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CPRO_28200	COG2333	competence protein COMEC
CPRO_28200	COG0658	competence protein
CPRO_28210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPRO_28230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPRO_28250	COG1970	mechanosensitive ion channel activity
CPRO_28260	COG2884	Cell division ATP-binding protein ftsE
CPRO_28300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CPRO_28310	COG1192	Involved in chromosome partitioning
CPRO_28330	COG0784	Response regulator, receiver
CPRO_28330	COG0835	chemotaxis
CPRO_28340	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CPRO_28350	COG1776	CheC inhibitor of MCP methylation
CPRO_28360	COG4786	Flagellar basal body rod
CPRO_28370	COG4786	Flagellar basal body rod
CPRO_28380	COG1191	sigma factor activity
CPRO_28390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CPRO_28400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CPRO_28410	COG1684	flagellar biosynthetic protein fliR
CPRO_28420	COG1987	bacterial-type flagellum assembly
CPRO_28450	COG2201	protein-glutamate methylesterase activity
CPRO_28460	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CPRO_28460	COG1776	CheC inhibitor of MCP methylation
CPRO_28510	COG4786	Flagellar basal body rod
CPRO_28570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CPRO_28620	COG2201	protein-glutamate methylesterase activity
CPRO_28630	COG2747	anti-sigma28 factor FlgM
CPRO_28680	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CPRO_28690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CPRO_28710	COG1126	abc transporter atp-binding protein
CPRO_28720	COG0765	amino acid transport
CPRO_28860	COG0058	SHG alpha-glucan phosphorylase activity
CPRO_28910	COG2890	protein-(glutamine-N5) methyltransferase activity
CPRO_28920	COG3872	metal-dependent enzyme
CPRO_28930	COG0254	rRNA binding
CPRO_29010	COG0671	phosphoesterase, PA-phosphatase related
CPRO_29090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CPRO_29100	COG0776	regulation of translation
CPRO_29110	COG3956	TIGRFAM MazG family protein
CPRO_29130	COG0493	'glutamate synthase
CPRO_29130	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CPRO_29140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPRO_29150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPRO_29170	COG0602	queuosine metabolic process
CPRO_29180	COG0756	dUTP diphosphatase activity
CPRO_29190	COG2720	vancomycin resistance protein
CPRO_29210	COG2011	ABC-type metal ion transport system permease component
CPRO_29220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPRO_29260	COG0352	thiamine-phosphate diphosphorylase activity
CPRO_29260	COG0351	phosphomethylpyrimidine kinase
CPRO_29310	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPRO_29330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CPRO_29360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CPRO_29370	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPRO_29380	COG0137	argininosuccinate synthase activity
CPRO_29450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPRO_29460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPRO_29470	COG1396	sequence-specific DNA binding
CPRO_29480	COG3842	ATPase activity
CPRO_29490	COG1176	ABC-type spermidine putrescine transport system, permease component I
CPRO_29500	COG1177	transmembrane transport
CPRO_29510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CPRO_29550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPRO_29580	COG1982	Orn Lys Arg decarboxylase major
CPRO_29610	COG0517	IMP dehydrogenase activity
CPRO_29610	COG1125	glycine betaine transport
CPRO_29620	COG1174	glycine betaine transport
CPRO_29630	COG1174	glycine betaine transport
CPRO_29650	COG2226	methyltransferase
CPRO_29680	COG0583	DNA-binding transcription factor activity
CPRO_29750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CPRO_29760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPRO_29770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPRO_29820	COG0662	Cupin 2, conserved barrel domain protein
CPRO_29830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPRO_29840	COG1393	Belongs to the ArsC family
CPRO_29870	COG1573	uracil-dna glycosylase
CPRO_29880	COG0705	Rhomboid family
CPRO_29880	COG0457	Tetratricopeptide repeat
CPRO_29930	COG2171	N-acyltransferase activity
CPRO_29940	COG1473	amidohydrolase
CPRO_30060	COG5002	protein histidine kinase activity
CPRO_30070	COG0745	RESPONSE REGULATOR receiver
CPRO_30200	COG0357	Ribosomal RNA small subunit methyltransferase G
CPRO_30230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CPRO_30240	COG1847	R3H domain protein
CPRO_30260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPRO_30280	COG0230	Belongs to the bacterial ribosomal protein bL34 family