locus-tag	class	description
K5I23_00120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5I23_00130	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K5I23_00180	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K5I23_00195	COG0436	Aminotransferase
K5I23_00200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5I23_00210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5I23_00215	COG0667	Aldo Keto reductase
K5I23_00220	COG1120	ATPase activity
K5I23_00225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5I23_00230	COG0583	DNA-binding transcription factor activity
K5I23_00240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5I23_00255	COG0450	alkyl hydroperoxide reductase
K5I23_00265	COG4608	Belongs to the ABC transporter superfamily
K5I23_00270	COG0444	Belongs to the ABC transporter superfamily
K5I23_00280	COG0601	transmembrane transport
K5I23_00285	COG4166	transmembrane transport
K5I23_00290	COG0583	DNA-binding transcription factor activity
K5I23_00295	COG2003	Belongs to the UPF0758 family
K5I23_00300	COG0564	pseudouridine synthase activity
K5I23_00305	COG2878	Part of a membrane complex involved in electron transport
K5I23_00310	COG4657	Part of a membrane complex involved in electron transport
K5I23_00315	COG4660	Part of a membrane complex involved in electron transport
K5I23_00325	COG4658	electron transport chain
K5I23_00330	COG4656	Part of a membrane complex involved in electron transport
K5I23_00340	COG1477	protein flavinylation
K5I23_00350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5I23_00355	COG0006	proline dipeptidase activity
K5I23_00360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K5I23_00370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K5I23_00375	COG0495	leucyl-tRNA aminoacylation
K5I23_00380	COG0799	negative regulation of ribosome biogenesis
K5I23_00385	COG1713	HD superfamily hydrolase involved in NAD metabolism
K5I23_00390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5I23_00395	COG1534	Rna-binding protein
K5I23_00400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K5I23_00405	COG0552	protein localization to endoplasmic reticulum
K5I23_00425	COG0416	fatty acid biosynthetic process
K5I23_00430	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K5I23_00435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5I23_00440	COG0758	DNA mediated transformation
K5I23_00445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5I23_00450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5I23_00455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5I23_00460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5I23_00470	COG1074	ATP-dependent DNA helicase activity
K5I23_00475	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K5I23_00490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K5I23_00490	COG0674	pyruvate-flavodoxin oxidoreductase activity
K5I23_00515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5I23_00525	COG0546	phosphoglycolate phosphatase activity
K5I23_00530	COG0326	Molecular chaperone. Has ATPase activity
K5I23_00555	COG3853	Toxic anion resistance protein (TelA)
K5I23_00560	COG2310	stress, protein
K5I23_00565	COG2310	stress, protein
K5I23_00570	COG2310	stress, protein
K5I23_00585	COG1358	cellular component organization or biogenesis
K5I23_00600	COG2310	stress, protein
K5I23_00605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5I23_00610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5I23_00620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K5I23_00635	COG1297	OPT oligopeptide transporter protein
K5I23_00640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5I23_00665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5I23_00700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_00720	COG1522	sequence-specific DNA binding
K5I23_00720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_00730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5I23_00735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5I23_00740	COG1120	ATPase activity
K5I23_00745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5I23_00750	COG2226	methyltransferase
K5I23_00755	COG0303	'Molybdopterin
K5I23_00770	COG4214	carbohydrate transport
K5I23_00780	COG4213	ABC transporter substrate-binding protein
K5I23_00820	COG0667	Aldo Keto reductase
K5I23_00825	COG2801	Transposase and inactivated derivatives
K5I23_00895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5I23_00900	COG1288	antiporter activity
K5I23_00905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K5I23_00915	COG0674	pyruvate-flavodoxin oxidoreductase activity
K5I23_00920	COG1013	pyruvate-flavodoxin oxidoreductase activity
K5I23_00950	COG2033	superoxide reductase activity
K5I23_00965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5I23_00975	COG1151	hydroxylamine reductase activity
K5I23_00990	COG0457	Tetratricopeptide repeat
K5I23_00990	COG0463	Glycosyl transferase, family 2
K5I23_01000	COG2373	Large extracellular alpha-helical protein
K5I23_01020	COG3212	peptidase
K5I23_01025	COG5002	protein histidine kinase activity
K5I23_01040	COG2703	oxygen carrier activity
K5I23_01050	COG1442	glycosyl transferase family 8
K5I23_01065	COG1442	glycosyl transferase family 8
K5I23_01065	COG1216	Glycosyl transferase, family 2
K5I23_01070	COG1442	glycosyl transferase family 8
K5I23_01070	COG1216	Glycosyl transferase, family 2
K5I23_01085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5I23_01090	COG3959	Transketolase, thiamine diphosphate binding domain
K5I23_01110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5I23_01115	COG1442	glycosyl transferase family 8
K5I23_01115	COG1216	Glycosyl transferase, family 2
K5I23_01145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5I23_01165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K5I23_01175	COG1160	GTP binding
K5I23_01185	COG0765	amino acid transport
K5I23_01190	COG1126	abc transporter atp-binding protein
K5I23_01195	COG0191	fructose-bisphosphate aldolase activity
K5I23_01205	COG0577	efflux transmembrane transporter activity
K5I23_01210	COG1136	(ABC) transporter
K5I23_01225	COG1269	ATP hydrolysis coupled proton transport
K5I23_01230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5I23_01250	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5I23_01255	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K5I23_01260	COG1394	ATPase activity, coupled to movement of substances
K5I23_01270	COG1592	Rubrerythrin
K5I23_01275	COG0366	Alpha amylase catalytic
K5I23_01280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5I23_01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5I23_01315	COG0765	amino acid transport
K5I23_01320	COG1126	abc transporter atp-binding protein
K5I23_01345	COG1876	peptidase activity
K5I23_01350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5I23_01355	COG2264	protein methyltransferase activity
K5I23_01360	COG0484	heat shock protein binding
K5I23_01365	COG0443	Heat shock 70 kDa protein
K5I23_01375	COG1420	regulation of RNA biosynthetic process
K5I23_01395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K5I23_01405	COG0181	hydroxymethylbilane synthase activity
K5I23_01415	COG0113	porphobilinogen synthase activity
K5I23_01420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5I23_01425	COG1566	PFAM secretion protein HlyD family protein
K5I23_01430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5I23_01440	COG1366	Belongs to the anti-sigma-factor antagonist family
K5I23_01450	COG2274	protein secretion by the type I secretion system
K5I23_01455	COG2274	protein secretion by the type I secretion system
K5I23_01475	COG2172	sigma factor antagonist activity
K5I23_01480	COG2770	Histidine kinase
K5I23_01480	COG2208	phosphoserine phosphatase activity
K5I23_01515	COG0205	6-phosphofructokinase activity
K5I23_01535	COG0745	RESPONSE REGULATOR receiver
K5I23_01545	COG1132	(ABC) transporter
K5I23_01570	COG0628	permease
K5I23_01590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5I23_01595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5I23_01600	COG2226	methyltransferase
K5I23_01605	COG4496	protein, YerC YecD
K5I23_01610	COG0019	diaminopimelate decarboxylase activity
K5I23_01615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5I23_01620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K5I23_01625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5I23_01630	COG0740	serine-type endopeptidase activity
K5I23_01650	COG0792	nuclease activity
K5I23_01655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5I23_01660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5I23_01670	COG0681	Belongs to the peptidase S26 family
K5I23_01675	COG0335	large ribosomal subunit rRNA binding
K5I23_01680	COG0662	Cupin 2, conserved barrel domain protein
K5I23_01705	COG0739	heme binding
K5I23_01710	COG0493	'glutamate synthase
K5I23_01710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5I23_01725	COG1649	PFAM Uncharacterised BCR, COG1649
K5I23_01775	COG5564	TIM-barrel signal transduction protein
K5I23_01795	COG0737	Belongs to the 5'-nucleotidase family
K5I23_01800	COG0513	Belongs to the DEAD box helicase family
K5I23_01805	COG1649	PFAM Uncharacterised BCR, COG1649
K5I23_01805	COG0726	polysaccharide deacetylase
K5I23_01810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5I23_01815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5I23_01820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5I23_01830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5I23_01835	COG1418	mRNA catabolic process
K5I23_01840	COG1346	cytolysis
K5I23_01860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5I23_01930	COG2848	UPF0210 protein
K5I23_01935	COG3830	Belongs to the UPF0237 family
K5I23_01940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K5I23_01945	COG1522	sequence-specific DNA binding
K5I23_01950	COG0436	Aminotransferase
K5I23_01955	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K5I23_01970	COG1846	Transcriptional regulator
K5I23_02010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K5I23_02050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5I23_02055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5I23_02150	COG2088	sporulation resulting in formation of a cellular spore
K5I23_02160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K5I23_02295	COG0739	heme binding
K5I23_02580	COG1690	Belongs to the RtcB family
K5I23_02640	COG2337	Toxic component of a toxin-antitoxin (TA) module
K5I23_02660	COG1373	ATPase (AAA superfamily
K5I23_02700	COG2801	Transposase and inactivated derivatives
K5I23_02720	COG0732	type I restriction modification DNA specificity domain
K5I23_02730	COG3711	transcriptional antiterminator
K5I23_02735	COG3964	amidohydrolase
K5I23_02775	COG3964	amidohydrolase
K5I23_02825	COG3426	butyrate kinase activity
K5I23_02850	COG1921	L-seryl-tRNASec selenium transferase activity
K5I23_02855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5I23_02875	COG0549	Belongs to the carbamate kinase family
K5I23_02880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5I23_02885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5I23_02910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5I23_02910	COG0493	'glutamate synthase
K5I23_02915	COG0402	S-adenosylhomocysteine deaminase activity
K5I23_02925	COG2964	Protein conserved in bacteria
K5I23_02940	COG1058	Belongs to the CinA family
K5I23_02940	COG1546	Belongs to the CinA family
K5I23_02950	COG2080	2 iron, 2 sulfur cluster binding
K5I23_02955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K5I23_02960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K5I23_02965	COG2252	PERMEase
K5I23_02970	COG0402	S-adenosylhomocysteine deaminase activity
K5I23_02990	COG4475	Protein of unknown function (DUF436)
K5I23_03010	COG3409	Peptidoglycan-binding domain 1 protein
K5I23_03010	COG3757	hydrolase, family 25
K5I23_03045	COG2502	aspartate--ammonia ligase
K5I23_03050	COG0067	glutamate synthase
K5I23_03070	COG3707	response regulator
K5I23_03075	COG0504	CTP synthase activity
K5I23_03085	COG0745	RESPONSE REGULATOR receiver
K5I23_03110	COG0457	Tetratricopeptide repeat
K5I23_03130	COG1129	ABC transporter
K5I23_03140	COG4948	Mandelate Racemase Muconate Lactonizing
K5I23_03145	COG3386	PFAM SMP-30 Gluconolaconase
K5I23_03155	COG1028	Short-chain dehydrogenase reductase Sdr
K5I23_03160	COG1063	alcohol dehydrogenase
K5I23_03165	COG1414	Transcriptional regulator
K5I23_03180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5I23_03185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5I23_03190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5I23_03195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5I23_03195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K5I23_03220	COG1979	alcohol dehydrogenase
K5I23_03230	COG4806	L-rhamnose isomerase
K5I23_03235	COG3842	ATPase activity
K5I23_03240	COG1177	transmembrane transport
K5I23_03245	COG4149	molybdate abc transporter
K5I23_03255	COG1609	Transcriptional regulator
K5I23_03260	COG1609	Transcriptional regulator
K5I23_03265	COG3623	hexulose-6-phosphate isomerase
K5I23_03270	COG1070	Carbohydrate kinase
K5I23_03325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5I23_03345	COG4660	Part of a membrane complex involved in electron transport
K5I23_03350	COG4657	Part of a membrane complex involved in electron transport
K5I23_03365	COG1760	l-serine dehydratase
K5I23_03370	COG1760	l-serine dehydratase
K5I23_03375	COG0534	Mate efflux family protein
K5I23_03410	COG1321	iron dependent repressor
K5I23_03425	COG0840	transmembrane signaling receptor activity
K5I23_03430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5I23_03435	COG1121	(ABC) transporter
K5I23_03440	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5I23_03445	COG0735	belongs to the Fur family
K5I23_03460	COG4211	Belongs to the binding-protein-dependent transport system permease family
K5I23_03465	COG2207	Transcriptional regulator
K5I23_03465	COG4753	response regulator
K5I23_03470	COG2972	Histidine kinase
K5I23_03505	COG1937	Protein conserved in bacteria
K5I23_03510	COG2217	Heavy metal translocating P-type atpase
K5I23_03560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5I23_03570	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K5I23_03590	COG2205	protein histidine kinase activity
K5I23_03595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K5I23_03600	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K5I23_03605	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K5I23_03620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5I23_03625	COG0569	domain protein
K5I23_03635	COG2205	protein histidine kinase activity
K5I23_03640	COG0745	RESPONSE REGULATOR receiver
K5I23_03645	COG1757	Na H antiporter
K5I23_03660	COG3048	D-serine ammonia-lyase activity
K5I23_03665	COG2610	gluconate transmembrane transporter activity
K5I23_03670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5I23_03685	COG1349	DNA-binding transcription factor activity
K5I23_03695	COG1744	ABC transporter substrate-binding protein PnrA-like
K5I23_03700	COG3845	ABC transporter
K5I23_03705	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5I23_03710	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5I23_03715	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K5I23_03730	COG1349	DNA-binding transcription factor activity
K5I23_03735	COG2376	Dihydroxyacetone kinase
K5I23_03745	COG1105	Belongs to the carbohydrate kinase PfkB family
K5I23_03755	COG1879	ABC-type sugar transport system periplasmic component
K5I23_03760	COG1129	ABC transporter
K5I23_03765	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_03790	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K5I23_03810	COG0215	cysteine-tRNA ligase activity
K5I23_03815	COG1045	serine acetyltransferase
K5I23_03820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5I23_03825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5I23_03830	COG2137	regulation of response to DNA damage stimulus
K5I23_03835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5I23_03845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5I23_03850	COG0742	ribosomal rna small subunit methyltransferase
K5I23_03855	COG0322	excinuclease ABC activity
K5I23_03860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5I23_03865	COG0336	Belongs to the RNA methyltransferase TrmD family
K5I23_03870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5I23_03875	COG1837	Belongs to the UPF0109 family
K5I23_03880	COG0228	four-way junction DNA binding
K5I23_03885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5I23_03890	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K5I23_03915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5I23_03920	COG3850	Histidine kinase
K5I23_03920	COG5002	protein histidine kinase activity
K5I23_03925	COG0745	RESPONSE REGULATOR receiver
K5I23_03930	COG0012	GTP binding
K5I23_03950	COG0473	3-isopropylmalate dehydrogenase activity
K5I23_03955	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5I23_03960	COG0673	inositol 2-dehydrogenase activity
K5I23_03970	COG0463	Glycosyl transferase, family 2
K5I23_03995	COG1215	transferase activity, transferring glycosyl groups
K5I23_04005	COG1216	Glycosyl transferase, family 2
K5I23_04025	COG2246	polysaccharide biosynthetic process
K5I23_04030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5I23_04050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5I23_04055	COG0740	serine-type endopeptidase activity
K5I23_04060	COG1968	undecaprenyl-diphosphatase activity
K5I23_04085	COG1725	Transcriptional regulator
K5I23_04090	COG1131	(ABC) transporter
K5I23_04100	COG2186	Transcriptional regulator
K5I23_04110	COG4948	Mandelate Racemase Muconate Lactonizing
K5I23_04120	COG4948	Mandelate Racemase Muconate Lactonizing
K5I23_04125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5I23_04135	COG0733	neurotransmitter:sodium symporter activity
K5I23_04140	COG5002	protein histidine kinase activity
K5I23_04145	COG0745	RESPONSE REGULATOR receiver
K5I23_04150	COG4869	propanediol catabolic process
K5I23_04155	COG1573	uracil-dna glycosylase
K5I23_04165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5I23_04170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5I23_04175	COG2333	competence protein COMEC
K5I23_04175	COG0658	competence protein
K5I23_04235	COG0716	FMN binding
K5I23_04240	COG0148	phosphopyruvate hydratase activity
K5I23_04255	COG1309	transcriptional regulator
K5I23_04260	COG0300	oxidoreductase activity
K5I23_04265	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5I23_04300	COG0840	transmembrane signaling receptor activity
K5I23_04310	COG2186	Transcriptional regulator
K5I23_04325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5I23_04330	COG0683	leucine binding
K5I23_04335	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5I23_04355	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5I23_04360	COG2086	electron transfer activity
K5I23_04370	COG0277	FAD linked oxidase domain protein
K5I23_04385	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5I23_04405	COG1070	Carbohydrate kinase
K5I23_04435	COG3959	Transketolase, thiamine diphosphate binding domain
K5I23_04440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5I23_04460	COG4251	negative regulation of phosphorylation
K5I23_04475	COG1177	transmembrane transport
K5I23_04480	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5I23_04485	COG3842	ATPase activity
K5I23_04495	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K5I23_04520	COG4978	Transcriptional regulator
K5I23_04520	COG0789	Transcriptional regulator
K5I23_04535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5I23_04540	COG1393	Belongs to the ArsC family
K5I23_04545	COG4895	conserved protein (DUF2196)
K5I23_04560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5I23_04585	COG2337	Toxic component of a toxin-antitoxin (TA) module
K5I23_04610	COG0739	heme binding
K5I23_04730	COG4804	nuclease activity
K5I23_04750	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
K5I23_04755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_04760	COG1349	DNA-binding transcription factor activity
K5I23_04770	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K5I23_04775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K5I23_04785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K5I23_04795	COG1129	ABC transporter
K5I23_04800	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_04840	COG0402	S-adenosylhomocysteine deaminase activity
K5I23_04845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K5I23_04855	COG0167	dihydroorotate dehydrogenase activity
K5I23_04860	COG1979	alcohol dehydrogenase
K5I23_04875	COG0436	Aminotransferase
K5I23_04890	COG2385	sporulation resulting in formation of a cellular spore
K5I23_04895	COG0372	Belongs to the citrate synthase family
K5I23_04905	COG1129	ABC transporter
K5I23_04910	COG1879	ABC-type sugar transport system periplasmic component
K5I23_04915	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_04925	COG0673	inositol 2-dehydrogenase activity
K5I23_04930	COG1940	carbohydrate kinase activity
K5I23_04935	COG1940	carbohydrate kinase activity
K5I23_04945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5I23_04955	COG1253	flavin adenine dinucleotide binding
K5I23_04960	COG1185	polyribonucleotide nucleotidyltransferase activity
K5I23_04970	COG0196	riboflavin kinase activity
K5I23_04980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5I23_04990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K5I23_05000	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K5I23_05005	COG0195	Participates in both transcription termination and antitermination
K5I23_05010	COG0779	Required for maturation of 30S ribosomal subunits
K5I23_05015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5I23_05025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5I23_05035	COG3845	ABC transporter
K5I23_05040	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5I23_05045	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5I23_05065	COG5002	protein histidine kinase activity
K5I23_05070	COG0745	RESPONSE REGULATOR receiver
K5I23_05075	COG0704	Plays a role in the regulation of phosphate uptake
K5I23_05080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5I23_05085	COG0581	inorganic phosphate transmembrane transporter activity
K5I23_05090	COG0573	inorganic phosphate transmembrane transporter activity
K5I23_05145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5I23_05155	COG0243	molybdopterin cofactor binding
K5I23_05160	COG0437	4 iron, 4 sulfur cluster binding
K5I23_05180	COG2059	Chromate
K5I23_05200	COG3119	arylsulfatase activity
K5I23_05205	COG1609	Transcriptional regulator
K5I23_05210	COG0641	radical SAM
K5I23_05215	COG1331	Highly conserved protein containing a thioredoxin domain
K5I23_05220	COG1929	Belongs to the glycerate kinase type-1 family
K5I23_05230	COG2610	gluconate transmembrane transporter activity
K5I23_05240	COG3835	regulator
K5I23_05265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5I23_05275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5I23_05285	COG0583	DNA-binding transcription factor activity
K5I23_05305	COG4608	Belongs to the ABC transporter superfamily
K5I23_05310	COG0444	Belongs to the ABC transporter superfamily
K5I23_05315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5I23_05330	COG0626	cystathionine gamma-synthase activity
K5I23_05335	COG1349	DNA-binding transcription factor activity
K5I23_05360	COG1132	(ABC) transporter
K5I23_05385	COG3022	response to hydroperoxide
K5I23_05390	COG1966	Carbon starvation protein
K5I23_05395	COG0346	lactoylglutathione lyase activity
K5I23_05405	COG1349	DNA-binding transcription factor activity
K5I23_05410	COG3959	Transketolase, thiamine diphosphate binding domain
K5I23_05415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5I23_05420	COG1082	Xylose isomerase domain protein TIM barrel
K5I23_05425	COG1070	Carbohydrate kinase
K5I23_05430	COG1879	ABC-type sugar transport system periplasmic component
K5I23_05435	COG1129	ABC transporter
K5I23_05440	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_05465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5I23_05475	COG3620	sequence-specific DNA binding
K5I23_05490	COG0840	transmembrane signaling receptor activity
K5I23_05495	COG3969	phosphoadenosine phosphosulfate
K5I23_05500	COG1475	DNA binding
K5I23_05535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K5I23_05535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5I23_05545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5I23_05570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5I23_05585	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K5I23_05600	COG0436	Aminotransferase
K5I23_05655	COG3409	Peptidoglycan-binding domain 1 protein
K5I23_05655	COG3757	hydrolase, family 25
K5I23_05775	COG0740	serine-type endopeptidase activity
K5I23_05800	COG5484	DNA packaging
K5I23_05820	COG1192	Involved in chromosome partitioning
K5I23_05970	COG0423	glycine-tRNA ligase activity
K5I23_05980	COG0671	phosphoesterase, PA-phosphatase related
K5I23_05995	COG0268	Binds directly to 16S ribosomal RNA
K5I23_06100	COG0126	phosphoglycerate kinase activity
K5I23_06105	COG0149	triose-phosphate isomerase activity
K5I23_06110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5I23_06145	COG2827	Endonuclease containing a URI domain
K5I23_06160	COG0747	negative chemotaxis
K5I23_06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5I23_06180	COG0444	Belongs to the ABC transporter superfamily
K5I23_06185	COG4608	Belongs to the ABC transporter superfamily
K5I23_06195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5I23_06200	COG0697	spore germination
K5I23_06210	COG1307	EDD domain protein, DegV family
K5I23_06220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5I23_06220	COG1918	ferrous iron import across plasma membrane
K5I23_06225	COG0656	L-ascorbic acid biosynthetic process
K5I23_06245	COG1609	Transcriptional regulator
K5I23_06250	COG3711	transcriptional antiterminator
K5I23_06255	COG2190	(PTS) system
K5I23_06255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5I23_06255	COG1263	PTS System
K5I23_06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5I23_06270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5I23_06270	COG1263	PTS System
K5I23_06280	COG0363	glucosamine-6-phosphate deaminase activity
K5I23_06285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5I23_06290	COG2081	HI0933 family
K5I23_06300	COG0800	Aldolase
K5I23_06305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_06310	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K5I23_06360	COG0673	inositol 2-dehydrogenase activity
K5I23_06365	COG1609	Transcriptional regulator
K5I23_06380	COG1028	Short-chain dehydrogenase reductase Sdr
K5I23_06385	COG1592	Rubrerythrin
K5I23_06405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5I23_06415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5I23_06425	COG0708	Exodeoxyribonuclease III
K5I23_06430	COG0456	acetyltransferase
K5I23_06435	COG1687	branched-chain amino acid
K5I23_06440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K5I23_06445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5I23_06455	COG0590	tRNA wobble adenosine to inosine editing
K5I23_06470	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5I23_06485	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K5I23_06495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5I23_06510	COG1854	S-ribosylhomocysteine lyase activity
K5I23_06520	COG1546	Belongs to the CinA family
K5I23_06520	COG1058	Belongs to the CinA family
K5I23_06525	COG0513	Belongs to the DEAD box helicase family
K5I23_06535	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
K5I23_06540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5I23_06545	COG2011	ABC-type metal ion transport system permease component
K5I23_06550	COG1464	Belongs to the NlpA lipoprotein family
K5I23_06555	COG0039	L-malate dehydrogenase activity
K5I23_06560	COG0071	Belongs to the small heat shock protein (HSP20) family
K5I23_06630	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_06635	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_06645	COG1082	Xylose isomerase domain protein TIM barrel
K5I23_06650	COG1069	ribulokinase activity
K5I23_06665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5I23_06670	COG0434	BtpA family
K5I23_06675	COG1070	Carbohydrate kinase
K5I23_06680	COG1349	DNA-binding transcription factor activity
K5I23_06725	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K5I23_06735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5I23_06750	COG0534	Mate efflux family protein
K5I23_06760	COG0402	S-adenosylhomocysteine deaminase activity
K5I23_06805	COG0697	spore germination
K5I23_06810	COG0628	permease
K5I23_06815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K5I23_06820	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5I23_06835	COG1394	ATPase activity, coupled to movement of substances
K5I23_06845	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5I23_06865	COG1269	ATP hydrolysis coupled proton transport
K5I23_06885	COG1217	gtp-binding protein TYPA
K5I23_06910	COG0653	protein targeting
K5I23_06920	COG0494	nUDIX hydrolase
K5I23_06930	COG1283	sodium-dependent phosphate transmembrane transporter activity
K5I23_06940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5I23_06955	COG0187	DNA topoisomerase II activity
K5I23_06965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5I23_06975	COG0592	DNA-directed DNA polymerase activity
K5I23_06980	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5I23_06985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5I23_06990	COG0594	ribonuclease P activity
K5I23_06995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5I23_07005	COG1847	R3H domain protein
K5I23_07010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5I23_07015	COG0445	tRNA wobble uridine modification
K5I23_07020	COG0357	Ribosomal RNA small subunit methyltransferase G
K5I23_07025	COG1475	DNA binding
K5I23_07030	COG1192	Involved in chromosome partitioning
K5I23_07035	COG1475	DNA binding
K5I23_07040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5I23_07060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5I23_07085	COG0463	Glycosyl transferase, family 2
K5I23_07090	COG1091	dTDP-4-dehydrorhamnose reductase activity
K5I23_07105	COG1216	Glycosyl transferase, family 2
K5I23_07105	COG0438	transferase activity, transferring glycosyl groups
K5I23_07135	COG1215	transferase activity, transferring glycosyl groups
K5I23_07140	COG1216	Glycosyl transferase, family 2
K5I23_07210	COG0488	(ABC) transporter
K5I23_07230	COG0569	domain protein
K5I23_07250	COG1982	Orn Lys Arg decarboxylase major
K5I23_07255	COG3870	Protein conserved in bacteria
K5I23_07265	COG1774	PSP1 C-terminal conserved region
K5I23_07270	COG2768	binding domain, Protein
K5I23_07275	COG2890	protein-(glutamine-N5) methyltransferase activity
K5I23_07285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5I23_07285	COG0456	acetyltransferase
K5I23_07290	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K5I23_07310	COG0622	Phosphoesterase
K5I23_07315	COG1640	4-alpha-glucanotransferase
K5I23_07320	COG0058	SHG alpha-glucan phosphorylase activity
K5I23_07340	COG2217	Heavy metal translocating P-type atpase
K5I23_07345	COG2217	Heavy metal translocating P-type atpase
K5I23_07365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K5I23_07375	COG0714	Associated with various cellular activities
K5I23_07430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5I23_07440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K5I23_07450	COG0402	S-adenosylhomocysteine deaminase activity
K5I23_07455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5I23_07465	COG2233	PERMEase
K5I23_07470	COG0167	dihydroorotate dehydrogenase activity
K5I23_07475	COG1609	Transcriptional regulator
K5I23_07485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5I23_07520	COG1966	Carbon starvation protein
K5I23_07585	COG0561	phosphatase activity
K5I23_07590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5I23_07625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5I23_07645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5I23_07655	COG0137	argininosuccinate synthase activity
K5I23_07665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K5I23_07670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K5I23_07675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5I23_07680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5I23_07685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5I23_07700	COG0028	Belongs to the TPP enzyme family
K5I23_07705	COG0440	acetolactate synthase activity
K5I23_07710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5I23_07720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5I23_07720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5I23_07725	COG0456	acetyltransferase
K5I23_07730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5I23_07740	COG1592	Rubrerythrin
K5I23_07750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5I23_07755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5I23_07760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5I23_07765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5I23_07770	COG2070	2-Nitropropane dioxygenase
K5I23_07775	COG1028	Short-chain dehydrogenase reductase Sdr
K5I23_07780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5I23_07785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5I23_07800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5I23_07810	COG0051	transcription antitermination factor activity, RNA binding
K5I23_07815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5I23_07820	COG0088	Forms part of the polypeptide exit tunnel
K5I23_07825	COG0089	rRNA binding
K5I23_07835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5I23_07840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5I23_07845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5I23_07850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5I23_07855	COG0255	Belongs to the universal ribosomal protein uL29 family
K5I23_07860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5I23_07865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5I23_07870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5I23_07875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5I23_07880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5I23_07885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5I23_07890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5I23_07895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K5I23_07900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5I23_07910	COG0200	Binds to the 23S rRNA
K5I23_07920	COG0563	adenylate kinase activity
K5I23_07925	COG0024	Methionine aminopeptidase
K5I23_07935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5I23_07940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5I23_07945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5I23_07955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5I23_07960	COG0202	RNA polymerase activity
K5I23_07965	COG0203	ribosomal protein L17
K5I23_07980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5I23_07985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5I23_08005	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K5I23_08015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5I23_08025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5I23_08035	COG2502	aspartate--ammonia ligase
K5I23_08060	COG0037	tRNA processing
K5I23_08065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K5I23_08070	COG0463	Glycosyl transferase, family 2
K5I23_08080	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K5I23_08090	COG2183	response to ionizing radiation
K5I23_08100	COG0840	transmembrane signaling receptor activity
K5I23_08120	COG3620	sequence-specific DNA binding
K5I23_08175	COG3628	GPW Gp25 family protein
K5I23_08180	COG3299	homolog of phage Mu protein gp47
K5I23_08230	COG0534	Mate efflux family protein
K5I23_08250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K5I23_08270	COG3906	Belongs to the UPF0473 family
K5I23_08275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5I23_08285	COG0481	GTPase activity
K5I23_08300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5I23_08320	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K5I23_08330	COG2188	Transcriptional regulator
K5I23_08350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_08385	COG1879	ABC-type sugar transport system periplasmic component
K5I23_08390	COG1129	ABC transporter
K5I23_08395	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_08405	COG2188	Transcriptional regulator
K5I23_08410	COG0444	Belongs to the ABC transporter superfamily
K5I23_08420	COG3608	succinylglutamate desuccinylase aspartoacylase
K5I23_08425	COG0534	Mate efflux family protein
K5I23_08450	COG0733	neurotransmitter:sodium symporter activity
K5I23_08455	COG3033	Beta-eliminating lyase
K5I23_08460	COG4974	Belongs to the 'phage' integrase family
K5I23_08470	COG0069	glutamate synthase activity
K5I23_08475	COG1063	alcohol dehydrogenase
K5I23_08480	COG0583	DNA-binding transcription factor activity
K5I23_08495	COG0488	(ABC) transporter
K5I23_08505	COG1328	CTP reductase activity
K5I23_08535	COG0577	efflux transmembrane transporter activity
K5I23_08535	COG1136	(ABC) transporter
K5I23_08540	COG0366	Alpha amylase catalytic
K5I23_08540	COG3103	Sh3 type 3 domain protein
K5I23_08545	COG0058	SHG alpha-glucan phosphorylase activity
K5I23_08550	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K5I23_08555	COG0826	peptidase U32
K5I23_08570	COG0424	maF-like protein
K5I23_08575	COG1077	Cell shape determining protein MreB Mrl
K5I23_08590	COG0768	penicillin binding
K5I23_08595	COG2894	cell division
K5I23_08600	COG1803	Methylglyoxal synthase
K5I23_08605	COG0124	histidyl-tRNA synthetase
K5I23_08610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5I23_08620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5I23_08625	COG1396	sequence-specific DNA binding
K5I23_08635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5I23_08640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5I23_08665	COG1129	ABC transporter
K5I23_08670	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_08695	COG2376	Dihydroxyacetone kinase
K5I23_08720	COG0149	triose-phosphate isomerase activity
K5I23_08725	COG0698	ribose 5-phosphate isomerase
K5I23_08730	COG1737	Transcriptional regulator
K5I23_08740	COG1328	CTP reductase activity
K5I23_08745	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5I23_08755	COG3845	ABC transporter
K5I23_08760	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5I23_08770	COG1744	ABC transporter substrate-binding protein PnrA-like
K5I23_08775	COG2188	Transcriptional regulator
K5I23_08785	COG1482	cell wall glycoprotein biosynthetic process
K5I23_08795	COG1940	carbohydrate kinase activity
K5I23_08805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K5I23_08805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5I23_08815	COG1940	carbohydrate kinase activity
K5I23_08820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K5I23_08825	COG2207	Transcriptional regulator
K5I23_08825	COG4753	response regulator
K5I23_08830	COG2972	Histidine kinase
K5I23_08840	COG1129	ABC transporter
K5I23_08845	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_08855	COG1609	Transcriptional regulator
K5I23_08865	COG3845	ABC transporter
K5I23_08870	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5I23_08875	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5I23_08885	COG1132	(ABC) transporter
K5I23_08890	COG1132	(ABC) transporter
K5I23_08915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5I23_08925	COG2959	enzyme of heme biosynthesis
K5I23_08930	COG1104	cysteine desulfurase activity
K5I23_08935	COG0301	tRNA thio-modification
K5I23_08940	COG1058	Belongs to the CinA family
K5I23_08940	COG1546	Belongs to the CinA family
K5I23_08965	COG0730	response to heat
K5I23_08970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5I23_08975	COG0698	ribose 5-phosphate isomerase
K5I23_08980	COG1214	PFAM Peptidase M22, glycoprotease
K5I23_08985	COG0802	atpase or kinase
K5I23_08995	COG0772	Belongs to the SEDS family
K5I23_09005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5I23_09005	COG0574	Belongs to the PEP-utilizing enzyme family
K5I23_09010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K5I23_09020	COG0193	aminoacyl-tRNA hydrolase activity
K5I23_09025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5I23_09035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5I23_09040	COG1773	rubredoxin
K5I23_09040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5I23_09045	COG0646	methionine synthase
K5I23_09045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5I23_09050	COG0018	arginyl-trna synthetase
K5I23_09060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K5I23_09065	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5I23_09075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5I23_09080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5I23_09085	COG0250	Participates in transcription elongation, termination and antitermination
K5I23_09090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5I23_09095	COG0081	regulation of translation
K5I23_09100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5I23_09105	COG0222	ribosome binding
K5I23_09110	COG1132	(ABC) transporter
K5I23_09115	COG1132	(ABC) transporter
K5I23_09120	COG1309	transcriptional regulator
K5I23_09130	COG1686	Belongs to the peptidase S11 family
K5I23_09135	COG2873	o-acetylhomoserine
K5I23_09145	COG2201	protein-glutamate methylesterase activity
K5I23_09160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5I23_09165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5I23_09180	COG1686	Belongs to the peptidase S11 family
K5I23_09185	COG0166	Belongs to the GPI family
K5I23_09200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5I23_09210	COG1160	GTP binding
K5I23_09215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5I23_09220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5I23_09275	COG2205	protein histidine kinase activity
K5I23_09280	COG0745	RESPONSE REGULATOR receiver
K5I23_09345	COG0791	NLP P60 protein
K5I23_09345	COG1388	LysM domain
K5I23_09470	COG1484	DNA-dependent DNA replication
K5I23_09505	COG2226	methyltransferase
K5I23_09585	COG1475	DNA binding
K5I23_09590	COG1309	transcriptional regulator
K5I23_09600	COG1132	(ABC) transporter
K5I23_09620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5I23_09625	COG1994	Peptidase M50
K5I23_09635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5I23_09645	COG3874	Sporulation protein YtfJ
K5I23_09650	COG1686	Belongs to the peptidase S11 family
K5I23_09655	COG1187	pseudouridine synthase activity
K5I23_09665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5I23_09670	COG4770	biotin carboxylase activity
K5I23_09680	COG1561	YicC-like family, N-terminal region
K5I23_09685	COG2052	Domain of unknown function (DUF370)
K5I23_09690	COG0194	GDP metabolic process
K5I23_09700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5I23_09710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5I23_09720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5I23_09725	COG2738	Putative neutral zinc metallopeptidase
K5I23_09730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5I23_09730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5I23_09735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5I23_09745	COG0515	serine threonine protein kinase
K5I23_09745	COG2815	serine threonine protein kinase
K5I23_09750	COG1162	GTPase activity
K5I23_09790	COG0725	ABC transporter, periplasmic molybdate-binding protein
K5I23_09795	COG4149	molybdate abc transporter
K5I23_09815	COG3118	belongs to the thioredoxin family
K5I23_09880	COG1609	Transcriptional regulator
K5I23_09895	COG1129	ABC transporter
K5I23_09900	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_09910	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
K5I23_10075	COG1222	aaa ATPase
K5I23_10110	COG1960	acyl-CoA dehydrogenase activity
K5I23_10115	COG0426	domain, Protein
K5I23_10160	COG2376	Dihydroxyacetone kinase
K5I23_10170	COG1129	ABC transporter
K5I23_10175	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_10185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5I23_10205	COG1454	alcohol dehydrogenase
K5I23_10220	COG4656	Part of a membrane complex involved in electron transport
K5I23_10245	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
K5I23_10250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K5I23_10255	COG1396	sequence-specific DNA binding
K5I23_10260	COG1396	sequence-specific DNA binding
K5I23_10270	COG3804	dihydrodipicolinate reductase
K5I23_10275	COG2002	toxin-antitoxin pair type II binding
K5I23_10300	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K5I23_10315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5I23_10335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5I23_10350	COG0084	hydrolase, TatD family'
K5I23_10355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5I23_10355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5I23_10365	COG5002	protein histidine kinase activity
K5I23_10375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K5I23_10380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5I23_10385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5I23_10390	COG0297	glycogen (starch) synthase activity
K5I23_10395	COG2890	protein-(glutamine-N5) methyltransferase activity
K5I23_10400	COG3872	metal-dependent enzyme
K5I23_10405	COG5002	protein histidine kinase activity
K5I23_10410	COG0745	RESPONSE REGULATOR receiver
K5I23_10425	COG0406	alpha-ribazole phosphatase activity
K5I23_10430	COG0473	3-isopropylmalate dehydrogenase activity
K5I23_10440	COG2002	toxin-antitoxin pair type II binding
K5I23_10445	COG2715	membrane protein required for spore maturation
K5I23_10450	COG0700	Nucleoside recognition
K5I23_10455	COG0180	Tryptophanyl-tRNA synthetase
K5I23_10460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5I23_10490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5I23_10500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5I23_10515	COG1187	pseudouridine synthase activity
K5I23_10520	COG3835	regulator
K5I23_10525	COG2884	Cell division ATP-binding protein ftsE
K5I23_10530	COG2177	Part of the ABC transporter FtsEX involved in
K5I23_10535	COG0739	heme binding
K5I23_10540	COG0793	Belongs to the peptidase S41A family
K5I23_10545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5I23_10550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5I23_10565	COG5377	YqaJ viral recombinase family
K5I23_10570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5I23_10620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5I23_10660	COG0745	RESPONSE REGULATOR receiver
K5I23_10665	COG0488	(ABC) transporter
K5I23_10685	COG4474	Belongs to the UPF0398 family
K5I23_10690	COG4977	sequence-specific DNA binding
K5I23_10690	COG1917	Cupin 2, conserved barrel domain protein
K5I23_10705	COG1129	ABC transporter
K5I23_10710	COG1132	(ABC) transporter
K5I23_10715	COG1132	(ABC) transporter
K5I23_10725	COG0745	RESPONSE REGULATOR receiver
K5I23_10755	COG1132	(ABC) transporter
K5I23_10755	COG2375	cellular response to nickel ion
K5I23_10760	COG1132	(ABC) transporter
K5I23_10760	COG2375	cellular response to nickel ion
K5I23_10765	COG1917	Cupin 2, conserved barrel domain protein
K5I23_10765	COG2207	Transcriptional regulator
K5I23_10780	COG1129	ABC transporter
K5I23_10785	COG1132	(ABC) transporter
K5I23_10800	COG0745	RESPONSE REGULATOR receiver
K5I23_10815	COG1132	(ABC) transporter
K5I23_10820	COG0745	RESPONSE REGULATOR receiver
K5I23_10835	COG1129	ABC transporter
K5I23_10845	COG2375	cellular response to nickel ion
K5I23_10845	COG1132	(ABC) transporter
K5I23_10850	COG1132	(ABC) transporter
K5I23_10850	COG2375	cellular response to nickel ion
K5I23_10860	COG0745	RESPONSE REGULATOR receiver
K5I23_10870	COG1132	(ABC) transporter
K5I23_10870	COG2375	cellular response to nickel ion
K5I23_10875	COG1132	(ABC) transporter
K5I23_10890	COG0745	RESPONSE REGULATOR receiver
K5I23_11080	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K5I23_11200	COG1131	(ABC) transporter
K5I23_11230	COG0110	maltose O-acetyltransferase activity
K5I23_11260	COG1323	Belongs to the UPF0348 family
K5I23_11265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5I23_11280	COG0583	DNA-binding transcription factor activity
K5I23_11330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K5I23_11335	COG0066	3-isopropylmalate dehydratase activity
K5I23_11370	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K5I23_11430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_11465	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_11470	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_11495	COG1720	tRNA m6t6A37 methyltransferase activity
K5I23_11510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5I23_11515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5I23_11525	COG1185	polyribonucleotide nucleotidyltransferase activity
K5I23_11530	COG4481	Protein conserved in bacteria
K5I23_11535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5I23_11540	COG0009	L-threonylcarbamoyladenylate synthase
K5I23_11545	COG0237	dephospho-CoA kinase activity
K5I23_11550	COG0739	heme binding
K5I23_11550	COG0741	lytic transglycosylase activity
K5I23_11550	COG1196	nuclear chromosome segregation
K5I23_11555	COG1362	aminopeptidase activity
K5I23_11565	COG2431	L-lysine efflux transmembrane transporter activity
K5I23_11570	COG0085	RNA polymerase activity
K5I23_11575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5I23_11580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5I23_11585	COG0049	tRNA binding
K5I23_11590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5I23_11595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5I23_11600	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5I23_11605	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5I23_11620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5I23_11650	COG0668	transmembrane transport
K5I23_11655	COG2207	Transcriptional regulator
K5I23_11660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5I23_11665	COG1085	galactose-1-phosphate uridylyltransferase
K5I23_11675	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K5I23_11700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5I23_11715	COG0693	protein deglycase activity
K5I23_11720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5I23_11740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5I23_11745	COG0826	peptidase U32
K5I23_11750	COG0217	transcriptional regulatory protein
K5I23_11755	COG2001	Belongs to the MraZ family
K5I23_11770	COG0768	penicillin binding
K5I23_11780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5I23_11785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5I23_11790	COG0772	Belongs to the SEDS family
K5I23_11795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5I23_11800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5I23_11810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5I23_11820	COG1247	-acetyltransferase
K5I23_11825	COG0187	DNA topoisomerase II activity
K5I23_11845	COG0410	ABC transporter
K5I23_11865	COG0683	leucine binding
K5I23_11870	COG2972	Histidine kinase
K5I23_11875	COG4753	response regulator
K5I23_11875	COG2207	Transcriptional regulator
K5I23_11880	COG1802	Transcriptional regulator
K5I23_11890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5I23_11920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5I23_11925	COG1739	Uncharacterized protein family UPF0029
K5I23_11930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K5I23_11935	COG0358	DNA primase activity
K5I23_11940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5I23_11960	COG0110	maltose O-acetyltransferase activity
K5I23_11995	COG0328	RNA-DNA hybrid ribonuclease activity
K5I23_12000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5I23_12005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K5I23_12030	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K5I23_12035	COG0359	binds to the 23S rRNA
K5I23_12040	COG0305	Participates in initiation and elongation during chromosome replication
K5I23_12045	COG0037	tRNA processing
K5I23_12060	COG1105	Belongs to the carbohydrate kinase PfkB family
K5I23_12075	COG0482	sulfurtransferase activity
K5I23_12085	COG1132	(ABC) transporter
K5I23_12090	COG1132	(ABC) transporter
K5I23_12100	COG0646	methionine synthase
K5I23_12100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5I23_12105	COG1410	methionine synthase
K5I23_12105	COG0646	methionine synthase
K5I23_12140	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K5I23_12165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5I23_12170	COG2364	Membrane
K5I23_12180	COG2964	Protein conserved in bacteria
K5I23_12190	COG3033	Beta-eliminating lyase
K5I23_12195	COG0733	neurotransmitter:sodium symporter activity
K5I23_12200	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5I23_12225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5I23_12230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5I23_12235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5I23_12245	COG1381	Involved in DNA repair and RecF pathway recombination
K5I23_12250	COG1193	negative regulation of DNA recombination
K5I23_12260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5I23_12265	COG1396	sequence-specific DNA binding
K5I23_12270	COG1028	Short-chain dehydrogenase reductase Sdr
K5I23_12280	COG0072	phenylalanine-tRNA ligase activity
K5I23_12280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5I23_12285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5I23_12300	COG3142	Participates in the control of copper homeostasis
K5I23_12320	COG1396	sequence-specific DNA binding
K5I23_12375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5I23_12390	COG1396	sequence-specific DNA binding
K5I23_12395	COG0768	penicillin binding
K5I23_12410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5I23_12415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5I23_12420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5I23_12425	COG2246	polysaccharide biosynthetic process
K5I23_12485	COG1260	myo-inositol-1-phosphate synthase
K5I23_12490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_12495	COG0673	inositol 2-dehydrogenase activity
K5I23_12500	COG1609	Transcriptional regulator
K5I23_12510	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_12525	COG0346	lactoylglutathione lyase activity
K5I23_12530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5I23_12535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5I23_12555	COG0598	Magnesium transport protein CorA
K5I23_12565	COG1959	2 iron, 2 sulfur cluster binding
K5I23_12575	COG2873	o-acetylhomoserine
K5I23_12585	COG1970	mechanosensitive ion channel activity
K5I23_12590	COG1396	sequence-specific DNA binding
K5I23_12595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5I23_12635	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5I23_12640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5I23_12660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5I23_12665	COG5012	cobalamin binding
K5I23_12670	COG0739	heme binding
K5I23_12670	COG0741	lytic transglycosylase activity
K5I23_12670	COG1196	nuclear chromosome segregation
K5I23_12675	COG0525	valine-tRNA ligase activity
K5I23_12690	COG2172	sigma factor antagonist activity
K5I23_12715	COG0310	cobalt ion transport
K5I23_12800	COG0519	Catalyzes the synthesis of GMP from XMP
K5I23_12810	COG2155	Conserved Protein
K5I23_12830	COG1033	growth of symbiont in host cell
K5I23_12830	COG2409	Drug exporters of the RND superfamily
K5I23_12855	COG0351	phosphomethylpyrimidine kinase
K5I23_12855	COG0352	thiamine-phosphate diphosphorylase activity
K5I23_12860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5I23_12870	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K5I23_12880	COG0840	transmembrane signaling receptor activity
K5I23_12925	COG1733	regulation of RNA biosynthetic process
K5I23_12955	COG1396	sequence-specific DNA binding
K5I23_12960	COG0393	Putative heavy-metal-binding
K5I23_12965	COG1528	Iron-storage protein
K5I23_12975	COG1811	Na channel or pump
K5I23_12980	COG0303	'Molybdopterin
K5I23_12990	COG1349	DNA-binding transcription factor activity
K5I23_13005	COG1129	ABC transporter
K5I23_13010	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5I23_13015	COG1879	ABC-type sugar transport system periplasmic component
K5I23_13055	COG2826	transposase and inactivated derivatives, IS30 family
K5I23_13130	COG4720	Psort location CytoplasmicMembrane, score
K5I23_13135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5I23_13140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K5I23_13145	COG0459	protein refolding
K5I23_13155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K5I23_13155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K5I23_13165	COG2337	Toxic component of a toxin-antitoxin (TA) module
K5I23_13170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5I23_13175	COG1328	CTP reductase activity
K5I23_13185	COG0295	cytidine deaminase activity
K5I23_13195	COG3845	ABC transporter
K5I23_13200	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5I23_13205	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5I23_13225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5I23_13230	COG0243	molybdopterin cofactor binding
K5I23_13250	COG0726	polysaccharide deacetylase
K5I23_13255	COG0445	tRNA wobble uridine modification
K5I23_13265	COG0737	Belongs to the 5'-nucleotidase family
K5I23_13275	COG3639	organic phosphonate transmembrane transporter activity
K5I23_13280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5I23_13290	COG1609	Transcriptional regulator
K5I23_13300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5I23_13310	COG1690	Belongs to the RtcB family
K5I23_13315	COG0561	phosphatase activity
K5I23_13320	COG2201	protein-glutamate methylesterase activity
K5I23_13330	COG0835	chemotaxis
K5I23_13335	COG0643	Histidine kinase
K5I23_13335	COG2198	Histidine kinase
K5I23_13360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K5I23_13395	COG1192	Involved in chromosome partitioning
K5I23_13415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5I23_13425	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
K5I23_13430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K5I23_13445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K5I23_13465	COG1815	bacterial-type flagellum-dependent cell motility
K5I23_13480	COG1677	Flagellar hook-basal body complex protein FliE
K5I23_13490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5I23_13500	COG1157	protein secretion by the type III secretion system
K5I23_13515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K5I23_13530	COG1582	Flagellar protein (FlbD)
K5I23_13540	COG1360	Flagellar Motor Protein
K5I23_13545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5I23_13550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5I23_13550	COG1776	CheC inhibitor of MCP methylation
K5I23_13555	COG2201	protein-glutamate methylesterase activity
K5I23_13570	COG1987	bacterial-type flagellum assembly
K5I23_13585	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K5I23_13595	COG4786	Flagellar basal body rod
K5I23_13600	COG4786	Flagellar basal body rod
K5I23_13605	COG1776	CheC inhibitor of MCP methylation
K5I23_13610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K5I23_13615	COG0840	transmembrane signaling receptor activity
K5I23_13625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5I23_13630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5I23_13640	COG0745	RESPONSE REGULATOR receiver
K5I23_13645	COG5002	protein histidine kinase activity
K5I23_13655	COG2826	transposase and inactivated derivatives, IS30 family
K5I23_13750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5I23_13765	COG1304	FMN binding
K5I23_13775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5I23_13785	COG2508	Transcriptional regulator
K5I23_13790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5I23_13795	COG0154	amidase activity
K5I23_13825	COG0534	Mate efflux family protein
K5I23_13850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5I23_13855	COG1137	ATPase activity
K5I23_13880	COG0561	phosphatase activity
K5I23_13885	COG2226	methyltransferase
K5I23_13900	COG1254	Belongs to the acylphosphatase family
K5I23_13910	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K5I23_13930	COG0835	chemotaxis
K5I23_13930	COG0784	Response regulator, receiver
K5I23_13940	COG3829	transcription factor binding
K5I23_13945	COG1461	Dihydroxyacetone kinase
K5I23_13950	COG2376	Dihydroxyacetone kinase
K5I23_13960	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5I23_13985	COG1917	Cupin 2, conserved barrel domain protein
K5I23_13985	COG4977	sequence-specific DNA binding
K5I23_14000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K5I23_14025	COG0583	DNA-binding transcription factor activity
K5I23_14030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5I23_14035	COG3608	succinylglutamate desuccinylase aspartoacylase
K5I23_14035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K5I23_14040	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K5I23_14050	COG0360	Binds together with S18 to 16S ribosomal RNA
K5I23_14055	COG0629	single-stranded DNA binding
K5I23_14060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5I23_14085	COG5002	protein histidine kinase activity
K5I23_14090	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5I23_14095	COG0456	acetyltransferase
K5I23_14095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K5I23_14110	COG0183	Belongs to the thiolase family
K5I23_14115	COG1024	Enoyl-CoA hydratase
K5I23_14120	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5I23_14125	COG1960	acyl-CoA dehydrogenase activity
K5I23_14130	COG2086	electron transfer activity
K5I23_14135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K5I23_14150	COG0252	asparaginase activity
K5I23_14165	COG1794	racemase activity, acting on amino acids and derivatives
K5I23_14180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5I23_14185	COG2088	sporulation resulting in formation of a cellular spore
K5I23_14190	COG1686	Belongs to the peptidase S11 family
K5I23_14205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5I23_14230	COG5002	protein histidine kinase activity
K5I23_14245	COG1175	transmembrane transport
K5I23_14250	COG0395	ABC-type sugar transport system, permease component
K5I23_14285	COG2033	superoxide reductase activity
K5I23_14305	COG1215	transferase activity, transferring glycosyl groups
K5I23_14320	COG3829	transcription factor binding
K5I23_14325	COG3681	Belongs to the UPF0597 family
K5I23_14340	COG1132	(ABC) transporter
K5I23_14355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5I23_14365	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K5I23_14370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5I23_14385	COG0138	bifunctional purine biosynthesis protein purh
K5I23_14390	COG0151	Belongs to the GarS family
K5I23_14400	COG1595	DNA-templated transcription, initiation
K5I23_14410	COG1671	Belongs to the UPF0178 family
K5I23_14425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5I23_14430	COG0077	Prephenate dehydratase
K5I23_14430	COG1605	Chorismate mutase
K5I23_14435	COG1115	amino acid carrier protein
K5I23_14440	COG1011	Hydrolase
K5I23_14455	COG0456	acetyltransferase
K5I23_14460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5I23_14475	COG4213	ABC transporter substrate-binding protein
K5I23_14480	COG1129	ABC transporter
K5I23_14485	COG4214	carbohydrate transport
K5I23_14490	COG1070	Carbohydrate kinase
K5I23_14515	COG0534	Mate efflux family protein
K5I23_14525	COG0577	efflux transmembrane transporter activity
K5I23_14545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5I23_14550	COG2818	Glycosylase
K5I23_14560	COG0733	neurotransmitter:sodium symporter activity
K5I23_14580	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5I23_14580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K5I23_14595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5I23_14600	COG1473	amidohydrolase
K5I23_14605	COG0039	L-malate dehydrogenase activity
K5I23_14620	COG0674	pyruvate-flavodoxin oxidoreductase activity
K5I23_14625	COG1013	pyruvate-flavodoxin oxidoreductase activity
K5I23_14630	COG3426	butyrate kinase activity
K5I23_14635	COG0280	phosphate acetyltransferase
K5I23_14670	COG0372	Belongs to the citrate synthase family
K5I23_14685	COG2323	membrane
K5I23_14690	COG0697	spore germination
K5I23_14710	COG0750	zinc metalloprotease
K5I23_14715	COG0745	RESPONSE REGULATOR receiver
K5I23_14730	COG0667	Aldo Keto reductase
K5I23_14745	COG0517	IMP dehydrogenase activity
K5I23_14745	COG0516	GMP reductase activity
K5I23_14765	COG3585	molybdate ion transport
K5I23_14790	COG4492	Belongs to the UPF0735 family
K5I23_14795	COG0460	homoserine dehydrogenase
K5I23_14800	COG0083	homoserine kinase activity
K5I23_14810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5I23_14810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K5I23_14815	COG1609	Transcriptional regulator
K5I23_14820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5I23_14860	COG1028	Short-chain dehydrogenase reductase Sdr
K5I23_14875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K5I23_14885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5I23_14890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K5I23_14895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K5I23_14900	COG0287	Prephenate dehydrogenase
K5I23_14905	COG0492	ferredoxin-NADP+ reductase activity
K5I23_14920	COG0318	PFAM AMP-dependent synthetase and ligase
K5I23_14945	COG0613	PHP domain protein
K5I23_14950	COG0281	malic enzyme
K5I23_14975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K5I23_14980	COG0436	Aminotransferase
K5I23_14995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5I23_15005	COG0438	transferase activity, transferring glycosyl groups
K5I23_15010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K5I23_15020	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5I23_15040	COG3623	hexulose-6-phosphate isomerase
K5I23_15055	COG3842	ATPase activity
K5I23_15060	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5I23_15065	COG1177	transmembrane transport
K5I23_15070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5I23_15080	COG0542	response to heat
K5I23_15100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5I23_15115	COG3854	ATPases associated with a variety of cellular activities
K5I23_15160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5I23_15165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5I23_15170	COG1570	exodeoxyribonuclease VII activity
K5I23_15175	COG1722	exodeoxyribonuclease VII activity
K5I23_15180	COG0142	geranyltranstransferase activity
K5I23_15185	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K5I23_15190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5I23_15195	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K5I23_15200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5I23_15205	COG1438	arginine binding
K5I23_15210	COG0497	DNA recombination
K5I23_15215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5I23_15220	COG4684	Psort location CytoplasmicMembrane, score
K5I23_15225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5I23_15230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K5I23_15235	COG0066	3-isopropylmalate dehydratase activity
K5I23_15250	COG1691	(AIR) carboxylase
K5I23_15275	COG1191	sigma factor activity
K5I23_15285	COG1191	sigma factor activity
K5I23_15290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_15300	COG1131	(ABC) transporter
K5I23_15305	COG1725	Transcriptional regulator
K5I23_15315	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K5I23_15345	COG1797	cobyrinic acid a,c-diamide synthase activity
K5I23_15350	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K5I23_15360	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K5I23_15375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K5I23_15380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5I23_15385	COG1492	cobalamin metabolic process
K5I23_15405	COG1053	succinate dehydrogenase
K5I23_15420	COG0444	Belongs to the ABC transporter superfamily
K5I23_15425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5I23_15430	COG0601	transmembrane transport
K5I23_15435	COG0747	negative chemotaxis
K5I23_15440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5I23_15450	COG3459	Glycosyltransferase 36 associated
K5I23_15460	COG0612	Peptidase, M16
K5I23_15465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5I23_15470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5I23_15475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5I23_15480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5I23_15485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5I23_15495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K5I23_15500	COG1335	isochorismatase
K5I23_15515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K5I23_15520	COG1592	Rubrerythrin
K5I23_15520	COG1773	rubredoxin
K5I23_15545	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5I23_15555	COG1737	Transcriptional regulator
K5I23_15565	COG1175	transmembrane transport
K5I23_15570	COG0395	ABC-type sugar transport system, permease component
K5I23_15575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5I23_15580	COG3842	ATPase activity
K5I23_15585	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5I23_15590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K5I23_15610	COG4974	Belongs to the 'phage' integrase family
K5I23_15635	COG1862	Preprotein translocase
K5I23_15640	COG0343	queuine tRNA-ribosyltransferase activity
K5I23_15645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5I23_15655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5I23_15660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5I23_15665	COG0527	aspartate kinase activity
K5I23_15675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K5I23_15675	COG0140	phosphoribosyl-ATP diphosphatase activity
K5I23_15680	COG0107	imidazoleglycerol-phosphate synthase activity
K5I23_15700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5I23_15705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5I23_15710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K5I23_15715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K5I23_15725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5I23_15730	COG0750	zinc metalloprotease
K5I23_15740	COG4589	Belongs to the CDS family
K5I23_15745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5I23_15750	COG0233	cytoplasmic translational termination
K5I23_15760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5I23_15765	COG1757	Na H antiporter
K5I23_15770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5I23_15785	COG0437	4 iron, 4 sulfur cluster binding
K5I23_15795	COG3859	Proton-coupled thiamine transporter YuaJ
K5I23_15810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5I23_15815	COG0052	Belongs to the universal ribosomal protein uS2 family
K5I23_15825	COG0733	neurotransmitter:sodium symporter activity
K5I23_15830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5I23_15855	COG1126	abc transporter atp-binding protein
K5I23_15860	COG0765	amino acid transport
K5I23_15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5I23_15870	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K5I23_15870	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K5I23_15880	COG1595	DNA-templated transcription, initiation
K5I23_15935	COG1028	Short-chain dehydrogenase reductase Sdr
K5I23_15950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5I23_15960	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K5I23_15965	COG1196	nuclear chromosome segregation
K5I23_15965	COG0741	lytic transglycosylase activity
K5I23_15965	COG0739	heme binding
K5I23_15970	COG0542	response to heat
K5I23_15995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K5I23_16005	COG1122	ATPase activity
K5I23_16010	COG0116	Belongs to the methyltransferase superfamily
K5I23_16010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5I23_16015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5I23_16020	COG2255	four-way junction helicase activity
K5I23_16025	COG0632	four-way junction helicase activity
K5I23_16030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K5I23_16045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5I23_16055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K5I23_16060	COG1098	S1 RNA binding domain
K5I23_16080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5I23_16085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5I23_16095	COG3757	hydrolase, family 25
K5I23_16095	COG3409	Peptidoglycan-binding domain 1 protein
K5I23_16275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5I23_16275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5I23_16330	COG3561	AntA/AntB antirepressor
K5I23_16345	COG1396	sequence-specific DNA binding
K5I23_16405	COG1395	domain, Protein
K5I23_16455	COG0116	Belongs to the methyltransferase superfamily
K5I23_16465	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K5I23_16475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K5I23_16480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5I23_16490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K5I23_16495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K5I23_16515	COG1481	regulation of sporulation
K5I23_16520	COG1660	Displays ATPase and GTPase activities
K5I23_16525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5I23_16535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K5I23_16540	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5I23_16570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5I23_16585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5I23_16590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5I23_16595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5I23_16600	COG0017	Asparaginyl-tRNA synthetase
K5I23_16610	COG0537	adenosine 5'-monophosphoramidase activity
K5I23_16615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5I23_16630	COG1461	Dihydroxyacetone kinase
K5I23_16650	COG1692	metallophosphoesterase
K5I23_16660	COG0765	amino acid transport
K5I23_16665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5I23_16670	COG0564	pseudouridine synthase activity
K5I23_16675	COG0254	rRNA binding
K5I23_16685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5I23_16695	COG0606	chelatase, subunit chli
K5I23_16715	COG0475	glutathione-regulated potassium exporter activity
K5I23_16725	COG0564	pseudouridine synthase activity
K5I23_16730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5I23_16735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5I23_16745	COG2302	S4 RNA-binding domain
K5I23_16750	COG1799	cell septum assembly
K5I23_16755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5I23_16765	COG1923	regulation of RNA biosynthetic process
K5I23_16770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5I23_16775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5I23_16780	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5I23_16790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5I23_16800	COG0426	domain, Protein
K5I23_16805	COG1773	rubredoxin
K5I23_16815	COG0556	nucleotide-excision repair
K5I23_16835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5I23_16840	COG1609	Transcriptional regulator
K5I23_16850	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K5I23_16860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5I23_16880	COG0358	DNA primase activity
K5I23_16920	COG1136	(ABC) transporter
K5I23_16930	COG0601	transmembrane transport
K5I23_16935	COG0747	negative chemotaxis
K5I23_16940	COG4608	Belongs to the ABC transporter superfamily
K5I23_16950	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
K5I23_16975	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5I23_16985	COG3956	TIGRFAM MazG family protein
K5I23_16990	COG2244	polysaccharide biosynthetic process
K5I23_16995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5I23_17000	COG0534	Mate efflux family protein
K5I23_17010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5I23_17015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5I23_17020	COG1490	D-aminoacyl-tRNA deacylase activity
K5I23_17025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5I23_17035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K5I23_17035	COG0539	negative regulation of cytoplasmic translation
K5I23_17045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5I23_17050	COG2081	HI0933 family
K5I23_17070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5I23_17075	COG2721	sulfolactate sulfo-lyase activity
K5I23_17090	COG1414	Transcriptional regulator
K5I23_17095	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5I23_17105	COG2826	transposase and inactivated derivatives, IS30 family
K5I23_17140	COG2373	Large extracellular alpha-helical protein
K5I23_17145	COG1971	Probably functions as a manganese efflux pump
K5I23_17155	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K5I23_17160	COG1242	4 iron, 4 sulfur cluster binding
K5I23_17170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K5I23_17175	COG3191	aminopeptidase activity
K5I23_17180	COG4684	Psort location CytoplasmicMembrane, score
K5I23_17185	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K5I23_17195	COG0534	Mate efflux family protein
K5I23_17200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5I23_17210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_17215	COG1609	Transcriptional regulator
K5I23_17220	COG0657	acetylesterase activity
K5I23_17235	COG1597	lipid kinase activity
K5I23_17245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5I23_17275	COG0488	(ABC) transporter
K5I23_17295	COG1192	Involved in chromosome partitioning